<commit_before><div class="help-sub-tab">
  <h4>The Cancer Analysis Bottleneck</h4>
  <p>With the speed at which cancer sequencing data is being produced and the rapidly reduced costs associated with this endeavor, the most significant bottleneck is interpreting the clinical significance of cancer variants from the wealth of existing and rapidly evolving medical literature.</p>
  <p>Interpretation requires bringing together multiple types of information from preclinical lab experiments to clinical trial resuts. However, additional challeneges remain in appropriately associating variants in the literature to curator-generated interpretations.</p>
  <p><i>Recommended reading:</i><a href="https://www.ncbi.nlm.nih.gov/pubmed/25222080" title="PubMed - Good et al Genome Biol 2014" target="_blank">Organizing knowledge to enable personalization of medicine in cancer</a></p>
  <h4>Cancer Variant Interpretation - Evidence Statements, Variant Summaries and Gene Summaries</h4>
  <p>For a primer on the fundamentals of cancer variant interpretation, we highly recommend that new users start by reading the CIViC paper and three recently published Standards and Guidelines proposals:
    <li><a href="http://biorxiv.org/content/early/2016/09/01/072892" title="BioRXiv - CIViC pre-print publication" target="_blank">CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer</a>.</li>
    <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/25741868" title="PubMed - ACMG variant guidelines publication" target="_blank">ACMG/AMP - Standards and guidelines for the interpretation of sequence variants</a>.</li>
    <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/27814769" title="PubMed - ClinGen MVLD guidelines publication" target="_blank">ClinGen - Somatic cancer variant curation and harmonization through consensus minimum variant level data (MVLD)</a>.</li>
    <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/27993330" title="PubMed - AMP cancer variant guidelines" target="_blank">AMP/ASCO/CAP - Standards and guidelines for the interpretation and reporting of sequence variants in cancer</a>.</li>
  </p>
</div><commit_msg>minor updates<commit_after><div class="help-sub-tab">
  <h4>The Cancer Analysis Bottleneck</h4>
  <p>With the recent advent of rapid and affordable tumor genome sequencing, interpreting the clinical significance of cancer variants from the wealth of existing and rapidly evolving medical literature has become a major bottleneck to realizing the potential of personalized cancer medicine.</p>
  <p>Associating cancer variants with concrete clinical actions by manual curation of high quality evidence is a great challenge. Creating useful interpretations requires integrating complex information from diverse sources ranging from preclinical lab experiments to clinical trial results. Creating and maintaining such interpretations will require the concerted effort of many experts at a large scale.</p>
  <p><i>Recommended reading:</i><a href="https://www.ncbi.nlm.nih.gov/pubmed/25222080" title="PubMed - Good et al Genome Biol 2014" target="_blank">Organizing knowledge to enable personalization of medicine in cancer</a></p>
  <h4>Cancer Variant Interpretation - Evidence Statements, Variant Summaries and Gene Summaries</h4>
  <p>For a primer on the fundamentals of cancer variant interpretation, we highly recommend that new users start by reading the CIViC paper and three recently published Standards and Guidelines proposals:
    <li><a href="http://biorxiv.org/content/early/2016/09/01/072892" title="BioRXiv - CIViC pre-print publication" target="_blank">CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer</a>.</li>
    <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/25741868" title="PubMed - ACMG variant guidelines publication" target="_blank">ACMG/AMP - Standards and guidelines for the interpretation of sequence variants</a>.</li>
    <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/27814769" title="PubMed - ClinGen MVLD guidelines publication" target="_blank">ClinGen - Somatic cancer variant curation and harmonization through consensus minimum variant level data (MVLD)</a>.</li>
    <li><a href="https://www.ncbi.nlm.nih.gov/pubmed/27993330" title="PubMed - AMP cancer variant guidelines" target="_blank">AMP/ASCO/CAP - Standards and guidelines for the interpretation and reporting of sequence variants in cancer</a>.</li>
  </p>
</div>
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