id
stringlengths 14
27
| vector
sequencelengths 1.02k
1.02k
| $meta
stringlengths 274
54.2k
|
|---|---|---|
10.1101/2020.03.25.007724 | [
0.014281179755926132,
0.8409544825553894,
0.6715970039367676,
0.46413567662239075,
-0.012462228536605835,
0.34080666303634644,
0.2685113251209259,
0.21346895396709442,
0.2805968225002289,
0.7136702537536621,
-0.44401299953460693,
-0.3467648923397064,
-0.19132137298583984,
-0.9395798444747925,
0.16455583274364471,
0.10027290880680084,
-0.5562127828598022,
-0.25090306997299194,
0.11742029339075089,
-0.10944907367229462,
0.10059218853712082,
0.295803964138031,
-0.7708532214164734,
0.7440682053565979,
-0.09408564120531082,
0.4792560338973999,
0.1539587527513504,
-0.543533444404602,
1.2626616954803467,
0.5971797108650208,
-0.6137396097183228,
-0.30820563435554504,
0.6224589347839355,
-0.717326819896698,
-0.399850457906723,
-0.1081872284412384,
0.754986047744751,
-0.06893301010131836,
0.00956503115594387,
0.0747716948390007,
0.5809504985809326,
0.5753348469734192,
-0.04870421066880226,
-0.4804609417915344,
0.005258804652839899,
-0.29049453139305115,
-0.2127283811569214,
-0.24536216259002686,
0.2331182360649109,
-0.3774857521057129,
-0.42891767621040344,
-0.023462187498807907,
0.3754231929779053,
-0.09454688429832458,
-0.04413946717977524,
0.17579670250415802,
0.2766858637332916,
-0.3262485861778259,
-0.8056541681289673,
0.9173346757888794,
-0.29143786430358887,
0.025278523564338684,
0.9312394857406616,
-1.0936930179595947,
1.254496455192566,
0.6778664588928223,
0.6216822862625122,
-0.6686724424362183,
0.22465814650058746,
-0.26910123229026794,
-0.3099629580974579,
0.2820763885974884,
-0.422309935092926,
0.14857330918312073,
0.04268195107579231,
-0.126194566488266,
0.7774131298065186,
-0.5086503028869629,
0.08926267176866531,
0.36520421504974365,
0.07702594995498657,
0.09804771840572357,
-0.5292444229125977,
0.5771487951278687,
-0.4943610727787018,
-0.11823880672454834,
-0.04424545541405678,
0.7272435426712036,
-0.7232422232627869,
0.6824897527694702,
-0.045065686106681824,
0.670892059803009,
-0.2777337431907654,
-0.3145475685596466,
0.07765234261751175,
0.9326843619346619,
-0.40158721804618835,
-0.07149315625429153,
-0.5115628838539124,
-0.8001570105552673,
0.8778508901596069,
0.47401314973831177,
-0.8665362596511841,
0.15495353937149048,
-0.40373465418815613,
0.5183466076850891,
0.5198626518249512,
-0.09533520042896271,
-1.2763296365737915,
-0.17053896188735962,
0.8298836946487427,
-0.1653580516576767,
-0.5294716954231262,
0.07747726887464523,
0.5792328715324402,
0.5000328421592712,
-0.12514916062355042,
1.0448918342590332,
-0.9644253849983215,
-0.1501276046037674,
-0.38644689321517944,
0.11690092831850052,
0.6039174199104309,
0.31631332635879517,
-0.006407873705029488,
0.40203237533569336,
-0.08031044155359268,
0.3892444372177124,
-0.3229089677333832,
0.15868279337882996,
-0.6594322323799133,
0.05648750811815262,
0.04619579389691353,
0.4833669662475586,
0.09857317805290222,
0.11544819921255112,
-0.17036029696464539,
0.8642886281013489,
0.2977577745914459,
-1.1272969245910645,
-0.1295367032289505,
-0.05805693939328194,
-1.1561284065246582,
0.5405382513999939,
-0.13523373007774353,
0.5427101850509644,
-0.5738873481750488,
-1.3211307525634766,
-0.5705325603485107,
-0.02780144289135933,
-0.631366491317749,
0.8475711345672607,
-0.3236505687236786,
-0.8864467740058899,
0.2564380168914795,
1.1127439737319946,
-0.1471276581287384,
0.2769797444343567,
0.1907137781381607,
-0.1231798455119133,
-0.06590524315834045,
0.14510294795036316,
-0.537236213684082,
0.3129923641681671,
-0.6630380749702454,
0.40627649426460266,
-0.15906338393688202,
0.2510100305080414,
0.020621664822101593,
-0.15178093314170837,
-0.14754310250282288,
-0.0017311321571469307,
-0.18243221938610077,
-0.09154785424470901,
0.59527987241745,
0.3352077603340149,
0.6449101567268372,
-0.31655439734458923,
0.4239444434642792,
0.40347322821617126,
0.27685070037841797,
-0.2676270604133606,
0.03124341182410717,
0.5695865750312805,
-0.6072405576705933,
0.6970071792602539,
-0.2639469802379608,
-0.015534084290266037,
0.05512449890375137,
-0.5102472305297852,
-0.45845699310302734,
0.40008923411369324,
-0.4107051193714142,
0.6021251678466797,
-0.26072168350219727,
-0.09715375304222107,
-0.5487611889839172,
0.5601499676704407,
0.18839751183986664,
-0.12945929169654846,
-0.5506352782249451,
1.0444512367248535,
0.08320006728172302,
0.04772364720702171,
-0.408944696187973,
0.2270841896533966,
0.23815441131591797,
0.49444445967674255,
-1.583763837814331,
0.3968154489994049,
1.0578091144561768,
-0.15277720987796783,
-0.2583775818347931,
0.3069559335708618,
0.22516940534114838,
0.30614152550697327,
-0.4268226623535156,
0.2713702619075775,
-0.4641677439212799,
0.4298326075077057,
-0.05735881254076958,
-0.6725669503211975,
0.5796371698379517,
0.5482165217399597,
0.32667672634124756,
0.759257435798645,
1.4173320531845093,
0.8716155290603638,
0.015275680460035801,
-0.19872677326202393,
0.530932605266571,
0.9291954636573792,
0.10252098739147186,
0.2821598947048187,
0.0179266519844532,
0.2073734551668167,
0.6459625959396362,
0.4825955629348755,
0.22641894221305847,
0.3146528899669647,
0.5021158456802368,
-0.004167663399130106,
0.709162712097168,
0.05271149426698685,
0.07987723499536514,
0.6511467695236206,
-0.7108640670776367,
0.009752127341926098,
-0.2100193202495575,
0.8907135128974915,
-0.5502227544784546,
0.5525714755058289,
0.5296862125396729,
0.0906018540263176,
-0.6297075748443604,
-0.3435147702693939,
-0.4800315797328949,
0.2026972472667694,
-0.027673868462443352,
-0.4956855773925781,
0.08872848004102707,
0.16822126507759094,
-0.08608289808034897,
0.17485637962818146,
1.2815637588500977,
0.6552556753158569,
-0.11804069578647614,
0.8747029304504395,
-0.024775637313723564,
-0.6971097588539124,
-0.8223050832748413,
-0.45632192492485046,
-0.9316449165344238,
-0.579526424407959,
-1.0504071712493896,
-0.403792142868042,
0.5887036919593811,
-0.1073451042175293,
0.45683300495147705,
0.3325515687465668,
-0.056857965886592865,
-0.6314733028411865,
-0.12595172226428986,
0.3498360812664032,
0.268527090549469,
0.5218638777732849,
-0.5384992361068726,
0.16889749467372894,
-0.22490741312503815,
0.4105314612388611,
-0.300045371055603,
0.8715388178825378,
0.31253543496131897,
-1.00888991355896,
0.3965260088443756,
-0.6504684090614319,
-0.4416809380054474,
-0.3391769826412201,
0.20435069501399994,
-0.3374370038509369,
0.14561323821544647,
0.18529145419597626,
-0.06432017683982849,
-0.3027998208999634,
-0.8188455700874329,
0.6461716294288635,
0.49684542417526245,
0.025980938225984573,
0.37439003586769104,
0.41020089387893677,
-0.17810241878032684,
0.6486355662345886,
-0.33692073822021484,
0.7134963274002075,
-0.8350700736045837,
0.17058619856834412,
0.6344050168991089,
-0.08982515335083008,
0.26491910219192505,
-0.7154412269592285,
-1.1106197834014893,
-0.6549509763717651,
-0.11963941901922226,
-0.041455548256635666,
-0.38007989525794983,
0.2309841364622116,
0.1121254563331604,
-1.1321184635162354,
0.2008834332227707,
-0.764481246471405,
-1.114078164100647,
0.10183735191822052,
-0.43984857201576233,
0.06756807863712311,
0.2972649931907654,
0.05698366463184357,
0.25995776057243347,
0.14671611785888672,
0.20416851341724396,
0.31585225462913513,
0.22860603034496307,
0.1390731930732727,
0.4295192360877991,
0.6583901047706604,
-0.29970741271972656,
0.5197476148605347,
0.04144373536109924,
0.0980614647269249,
0.2104092240333557,
0.4410344958305359,
-0.4876272678375244,
-0.04372198134660721,
0.7751373648643494,
0.4553079903125763,
-0.34067389369010925,
0.24977558851242065,
0.2609742283821106,
-0.0003774711221922189,
-0.018218887969851494,
0.14715880155563354,
-0.2346760630607605,
0.18855778872966766,
-0.18935994803905487,
-0.3001251220703125,
-1.4111576080322266,
-0.6605445146560669,
0.016869548708200455,
-0.240544393658638,
0.6850201487541199,
-0.713506817817688,
0.781189501285553,
1.3435568809509277,
-0.11535964161157608,
0.26988106966018677,
0.0901685431599617,
-0.11284353584051132,
0.6074246764183044,
0.20600341260433197,
0.9993613362312317,
-0.8185527324676514,
0.26963475346565247,
0.38836535811424255,
1.0077370405197144,
0.5475279688835144,
0.1383383870124817,
0.7252521514892578,
-0.6102609634399414,
1.004387617111206,
0.023440295830368996,
0.31103751063346863,
-0.2993732988834381,
0.047340936958789825,
-0.07038284093141556,
0.2403896003961563,
-0.20233044028282166,
-0.5815442204475403,
-0.6226973533630371,
0.5471094250679016,
0.1977505087852478,
-0.00839763879776001,
0.21310283243656158,
-0.6297391653060913,
-0.2841406762599945,
0.002278912113979459,
0.4785357713699341,
0.32765018939971924,
-0.15474896132946014,
0.23521851003170013,
0.13382919132709503,
-0.34170758724212646,
0.5698271989822388,
-0.4328900873661041,
-0.3209086060523987,
-0.2884804904460907,
0.5808351635932922,
-0.32085058093070984,
-1.0345344543457031,
-0.6671122312545776,
-0.5667424201965332,
0.1400354951620102,
0.16916804015636444,
0.6748846769332886,
-0.5408424139022827,
0.5137765407562256,
-0.06138689070940018,
-0.18478530645370483,
0.03997913375496864,
-0.9099123477935791,
0.24054162204265594,
0.4035648703575134,
-0.5926570892333984,
-0.9886026382446289,
-0.6058881282806396,
-0.0946802943944931,
0.14327110350131989,
-0.7461279034614563,
0.8961866497993469,
-0.4889119565486908,
0.7191092371940613,
-0.3034207224845886,
-0.565546452999115,
-0.7105742692947388,
0.11707066744565964,
0.13367095589637756,
0.44447314739227295,
0.280385285615921,
0.5523894429206848,
0.2152879685163498,
0.37630242109298706,
-0.6250253915786743,
0.48582756519317627,
-0.9828521609306335,
-0.4718809127807617,
-0.30281320214271545,
-0.629910945892334,
-0.6690087914466858,
-0.31572484970092773,
-0.5276603102684021,
0.5775763392448425,
-0.6997257471084595,
-0.4206182360649109,
0.3027285933494568,
0.26416218280792236,
-0.18955735862255096,
-0.38371285796165466,
0.98678058385849,
-0.44664204120635986,
0.4772403836250305,
1.3091721534729004,
0.019908757880330086,
0.0252549909055233,
-0.37258875370025635,
0.08321210741996765,
-0.7681623697280884,
0.8805029988288879,
0.3273213505744934,
0.34604740142822266,
0.3518465757369995,
-0.11952072381973267,
-0.1366317719221115,
0.10429801791906357,
0.5776713490486145,
-0.7040917873382568,
-0.7262325882911682,
-0.42778337001800537,
-0.37901994585990906,
-0.721648097038269,
0.10993905365467072,
-0.9107789993286133,
0.2956610321998596,
0.33897849917411804,
-0.24964451789855957,
0.3560265004634857,
-0.18575865030288696,
-0.08448335528373718,
-0.7500553131103516,
-0.36477765440940857,
-0.06041472405195236,
0.4963100552558899,
0.14919796586036682,
1.194927453994751,
-0.24458402395248413,
-0.8415312767028809,
0.013811305165290833,
0.3875703513622284,
-0.793231725692749,
-0.4800073206424713,
0.0038087063003331423,
-0.4230149984359741,
-1.0799493789672852,
-0.30707526206970215,
-0.5557095408439636,
-0.5964487791061401,
-0.8291752934455872,
-0.3264879882335663,
0.08382415026426315,
0.7120312452316284,
0.5877779722213745,
0.05506787821650505,
0.7092057466506958,
0.6199684739112854,
-0.7076907157897949,
-0.3799826204776764,
0.5751028656959534,
-0.013217535801231861,
0.07047306001186371,
-0.9833289384841919,
-0.9571542143821716,
-0.555898129940033,
-0.9685428738594055,
0.03603453189134598,
-0.6312869191169739,
0.6441265344619751,
-0.7047949433326721,
0.3736354112625122,
-0.12044478952884674,
1.1169317960739136,
0.6372683644294739,
0.5021302700042725,
0.005203772336244583,
-0.37167903780937195,
0.3793971836566925,
-0.09567345678806305,
-0.2751561105251312,
-0.062460072338581085,
-0.8129642009735107,
0.3619116544723511,
0.9867842197418213,
0.21473842859268188,
-0.6963691711425781,
0.27201494574546814,
-0.09667732566595078,
0.6634457111358643,
0.8980257511138916,
-0.9419497847557068,
-0.3214264214038849,
0.2888641953468323,
0.882163405418396,
-0.3671342134475708,
-0.46751677989959717,
-1.1614704132080078,
0.05458960309624672,
-0.07591655850410461,
0.35940390825271606,
0.27762043476104736,
-0.5887255668640137,
0.1273503601551056,
-0.09821835905313492,
0.9849057197570801,
-0.10783799737691879,
-0.14096273481845856,
0.052092451602220535,
-0.8066534399986267,
-0.4632572531700134,
0.47845664620399475,
-0.7768146395683289,
-0.24293963611125946,
-0.7717493176460266,
-0.4970736801624298,
0.2788994610309601,
0.08844155818223953,
0.0023454187903553247,
0.1470387727022171,
0.17833220958709717,
0.2796393930912018,
-0.24891029298305511,
1.114439845085144,
0.5314875841140747,
-0.05532772094011307,
-0.3996168076992035,
0.03207892179489136,
0.4305269122123718,
-0.24061591923236847,
0.09703919291496277,
1.0595192909240723,
-0.19685512781143188,
-0.17239157855510712,
-0.1332905888557434,
-0.04238951578736305,
-0.3674539029598236,
-0.531485378742218,
0.5336131453514099,
0.31844159960746765,
0.09496533125638962,
0.5603780746459961,
-0.295770525932312,
-0.3048083186149597,
0.14166991412639618,
1.09441077709198,
-0.10570675134658813,
0.6514888405799866,
0.8933313488960266,
0.10421304404735565,
-0.6171708106994629,
0.4047008156776428,
0.027107495814561844,
-0.5330584645271301,
-0.10885828733444214,
0.02003922499716282,
0.4475271701812744,
-0.6582203507423401,
0.3115667402744293,
0.09715747088193893,
-0.6340229511260986,
-0.5394148826599121,
-0.09465637058019638,
-0.14643968641757965,
-0.13718774914741516,
-0.14419837296009064,
-0.5164925456047058,
1.0863165855407715,
-0.47004950046539307,
0.29324743151664734,
-0.633393406867981,
-0.05400887876749039,
-0.3344728648662567,
-0.9026833772659302,
-0.11831485480070114,
-0.8173876404762268,
0.26180893182754517,
0.9501659274101257,
-0.398866206407547,
-0.3466762602329254,
0.3053649067878723,
1.2888613939285278,
-0.8284517526626587,
-0.19016465544700623,
1.0087765455245972,
-0.4577031135559082,
-0.44788748025894165,
-0.6063995361328125,
0.7414913773536682,
-0.22013871371746063,
0.12701939046382904,
0.2835192084312439,
1.1415109634399414,
0.2385827898979187,
-0.5755188465118408,
-0.42563000321388245,
0.2849873900413513,
1.4895637035369873,
0.552315354347229,
0.377927303314209,
0.07607235014438629,
0.3735587000846863,
0.24955125153064728,
-0.2582314908504486,
-0.48129305243492126,
0.3773258924484253,
-0.3587645888328552,
-0.2151598185300827,
-0.03944476321339607,
-0.7023197412490845,
0.6645950675010681,
0.4921664297580719,
-0.4546135365962982,
-0.05363704636693001,
-0.4085802733898163,
0.11808079481124878,
-0.07387889921665192,
0.23643681406974792,
0.14830352365970612,
-0.03317323327064514,
-0.41493573784828186,
-0.6578496694564819,
-0.1059536263346672,
-0.4709031879901886,
-0.18957164883613586,
0.6594287157058716,
0.032243333756923676,
0.34986594319343567,
0.28322961926460266,
0.11518606543540955,
0.37503722310066223,
0.019644131883978844,
-0.3935664892196655,
-0.4411613345146179,
-0.5822246670722961,
0.7330877184867859,
-0.24298782646656036,
0.13537827134132385,
0.8804571628570557,
0.19275762140750885,
-0.007851492613554,
0.5761925578117371,
-0.43042823672294617,
-0.4879477918148041,
0.4025069773197174,
0.4971114695072174,
-0.9579311013221741,
-0.3586539626121521,
-0.7320664525032043,
0.8747085332870483,
-0.8255475163459778,
-0.5585049390792847,
-0.5019407868385315,
-0.07815560698509216,
-0.03969241678714752,
0.49880141019821167,
0.2578430473804474,
0.7511857748031616,
0.42627760767936707,
-0.015361975878477097,
-0.21954134106636047,
0.7507066130638123,
0.8448479771614075,
-0.15544423460960388,
0.13027937710285187,
-0.3100109398365021,
0.35550495982170105,
-1.048538088798523,
0.38763922452926636,
0.5887683629989624,
-0.3174724876880646,
0.18948136270046234,
0.4026828408241272,
0.3210113048553467,
0.4486938714981079,
0.013445300050079823,
0.10036596655845642,
0.3208811581134796,
0.233387753367424,
0.28330159187316895,
-0.5963746905326843,
-0.9132522940635681,
-0.5774611830711365,
-0.04393612965941429,
-0.9457168579101562,
-0.4450930655002594,
0.5920029878616333,
-0.2070465087890625,
0.2191380113363266,
-0.7406339645385742,
-0.682111918926239,
0.233530193567276,
0.0918605774641037,
0.44277143478393555,
-0.16117368638515472,
0.20874811708927155,
0.4070549011230469,
0.22026224434375763,
0.17812250554561615,
-0.3089432716369629,
0.27464559674263,
-0.176535502076149,
-0.8463294506072998,
-0.5436264276504517,
-0.43207183480262756,
0.22777923941612244,
-0.2817085385322571,
-0.8055915236473083,
-0.3022594451904297,
-0.8206709027290344,
0.16947099566459656,
-0.09348088502883911,
-0.7139067649841309,
-0.8176700472831726,
-0.8352240324020386,
-0.4684007167816162,
-1.1867928504943848,
-0.1207135021686554,
-0.8484313488006592,
0.19393184781074524,
0.18655334413051605,
-0.7768011093139648,
0.05284597724676132,
0.05952976271510124,
1.1534141302108765,
-0.5299248695373535,
0.93956458568573,
-0.364027202129364,
0.8453325629234314,
-0.0471770204603672,
-0.23766374588012695,
1.2646018266677856,
1.2095369100570679,
0.1201632097363472,
-0.26468002796173096,
-0.5231795310974121,
-0.43088871240615845,
0.4216740131378174,
0.5689522624015808,
-0.49316614866256714,
0.5866435766220093,
0.1718693971633911,
0.019973235204815865,
0.19644586741924286,
-0.23737402260303497,
0.3556321859359741,
0.36168578267097473,
-0.5691366195678711,
-0.0686853751540184,
-0.3222615420818329,
-0.16514506936073303,
0.03768252208828926,
-0.4993608593940735,
0.283763587474823,
-0.4849172830581665,
-0.048406776040792465,
0.6749558448791504,
0.13707220554351807,
0.9256162643432617,
-0.11305635422468185,
-0.05156712606549263,
0.3374949097633362,
1.0046284198760986,
-0.2136395424604416,
0.07841058820486069,
0.6605142951011658,
-0.8151988387107849,
-0.5297308564186096,
0.4866572916507721,
0.2573246359825134,
-0.18178033828735352,
0.473890095949173,
0.11782993376255035,
-0.9636155366897583,
-0.20945365726947784,
0.9953340888023376,
-0.3116110861301422,
0.438023179769516,
1.3040320873260498,
-0.6466987133026123,
-0.6811370253562927,
0.46334126591682434,
0.05444684252142906,
-0.5999104976654053,
-0.40416112542152405,
0.7317209839820862,
-1.1933858394622803,
-0.04472406208515167,
0.4549071788787842,
0.38654330372810364,
0.8783792853355408,
0.22163888812065125,
0.4803059697151184,
-0.11890945583581924,
0.7761393189430237,
0.923214316368103,
0.5902799963951111,
0.38059139251708984,
0.15717604756355286,
-0.3032671809196472,
-0.16707462072372437,
-0.36888939142227173,
-0.684039294719696,
0.4232432246208191,
-0.5175262093544006,
-0.7609727382659912,
0.18148556351661682,
-0.27840137481689453,
-0.5068897604942322,
-0.48043984174728394,
-0.5363418459892273,
0.49078816175460815,
-0.452481210231781,
-0.42068925499916077,
0.7111910581588745,
0.3341277837753296,
0.027975456789135933,
0.5506353378295898,
-0.08251575380563736,
-0.4275270700454712,
-0.5853077173233032,
-0.667373776435852,
0.5899827480316162,
-0.3272816240787506,
-0.1281871199607849,
-0.40586912631988525,
-0.9015404582023621,
-0.6206082701683044,
-0.2723177373409271,
0.005719208158552647,
-0.6878118515014648,
-0.1070324257016182,
0.21319377422332764,
0.48953717947006226,
-0.2342720776796341,
-0.060797277837991714,
0.5264321565628052,
-0.024167783558368683,
0.8573513627052307,
-0.01588647998869419,
0.8438418507575989,
0.10589880496263504,
0.009364699013531208,
-0.8412383198738098,
-0.24028117954730988,
0.06781816482543945,
-0.02343631163239479,
0.4930303394794464,
-1.0367579460144043,
-0.07398445159196854,
-0.6319620013237,
-0.7588132619857788,
0.4823508858680725,
0.6823931932449341,
-0.7493352293968201,
-0.08154501765966415,
-0.9504753351211548,
-0.27371519804000854,
-0.7725568413734436,
0.20103336870670319,
-0.3625519871711731,
-0.37351614236831665,
0.5123449563980103,
-0.21459127962589264,
0.7862412929534912,
-1.3227895498275757,
4.051540851593018,
1.171172857284546,
0.6794208288192749,
-0.5798279643058777,
0.7223935723304749,
0.9840914011001587,
0.7692767977714539,
0.044333312660455704,
-0.2155424952507019,
-0.675234854221344,
-0.3042196035385132,
0.003346431301906705,
0.24650906026363373,
0.017517026513814926,
0.24535249173641205,
0.23827312886714935,
-1.0535553693771362,
-0.18390049040317535,
0.0889030322432518,
-1.0938470363616943,
-0.9940208792686462,
0.1588437408208847,
0.04776785895228386,
-0.36239853501319885,
0.5139787197113037,
-0.08054173737764359,
-0.6863425970077515,
-0.33517149090766907,
-0.3142468333244324,
-0.6603814363479614,
-0.050679732114076614,
-0.23923152685165405,
0.19635576009750366,
-0.3993711769580841,
-0.17152807116508484,
0.5833404064178467,
0.4087507128715515,
-0.07320374995470047,
-0.05887501314282417,
-0.068836510181427,
-0.3358546793460846,
-0.878841757774353,
-0.19659052789211273,
-0.4338024854660034,
-0.053589046001434326,
-0.30284303426742554,
-0.2232169210910797,
0.05922507494688034,
0.4097113013267517,
0.17472171783447266,
1.0882660150527954,
-0.9800715446472168,
0.6174213290214539,
-0.15137363970279694,
-1.014335036277771,
-0.036609385162591934,
0.22102683782577515,
-0.8191867470741272,
-0.2209029197692871,
0.39395734667778015,
0.74629145860672,
-0.15016107261180878,
-0.43963488936424255,
0.42316070199012756,
0.2854030132293701,
1.0763933658599854,
-0.052787210792303085,
0.542768120765686,
-0.4568321704864502,
-0.6366154551506042,
0.06526774168014526,
-0.6945022344589233,
-0.1448325663805008,
-0.44748327136039734,
0.3697487711906433,
-0.24995014071464539,
-0.1330047994852066,
0.7750040888786316,
-0.6966391801834106,
-0.5262369513511658,
0.01688413880765438,
-0.3196905851364136,
-0.018923571333289146,
-0.5616209506988525,
0.9889141321182251,
1.1098814010620117,
-0.9214951992034912,
-0.21088337898254395,
-0.9789509773254395,
0.6526205539703369,
-0.3707927465438843,
-0.3578161299228668,
-0.0024359102826565504,
-0.14766810834407806,
-0.08586040884256363
] | {"Title": "Protein QTL analysis of IGF-I and its binding proteins provides insights into growth biology", "Authors": "Bartell Eric, Fujimoto Masanobu, Khoury Jane C., Khoury Philip R., Vedantam Sailaja, Hirschhorn Joel, Dauber Andrew", "Abstract": "Abstract The growth hormone and insulin-like growth factor (IGF) system is integral to human growth. Genome-wide association studies (GWAS) have identified variants associated with height and located near the genes in this pathway. However, mechanisms underlying these genetic associations are not understood. To investigate the regulation of the genes in this pathway and mechanisms by which regulation could affect growth, we performed GWAS of measured serum protein levels of IGF-I, IGFBP-3, PAPP-A2, IGF-II, and IGFBP-5 in 839 children (3-18 years) from the Cincinnati Genomic Control Cohort. We identified variants associated with protein levels near IGFBP3 and IGFBP5 genes, which contain multiple signals of association with height and other skeletal growth phenotypes. Surprisingly, variants that associate with protein levels at these two loci do not colocalize with height associations, confirmed through conditional analysis. Rather, the IGFBP3 signal (associated with total IGFBP-3 and IGF-II levels) colocalizes with an association with sitting height ratio (SHR); the IGFBP5 signal (associated with IGFBP-5 levels) colocalizes with birth weight. Indeed, height-associated SNPs near genes encoding other proteins in this pathway are not associated with serum levels, possibly excluding PAPP-A2. Mendelian randomization supports a stronger relationship of measured serum levels with SHR (for IGFBP-3) and birth weight (for IGFBP-5) than with height. In conclusion, we begin to characterize the genetic regulation of serum levels of IGF-related proteins in childhood. Furthermore, our data strongly suggest the existence of growth-regulating mechanisms acting through IGF-related genes in ways that are not reflected in measured serum levels of the corresponding proteins.", "URL": "https://doi.org/10.1101/2020.03.25.007724"} |
10.1101/003475 | [
0.06540784984827042,
0.16824005544185638,
0.7145230770111084,
-0.32524213194847107,
0.1870124340057373,
1.2091286182403564,
0.5758505463600159,
-0.7815845012664795,
0.7170403003692627,
1.1422204971313477,
0.5990880131721497,
-0.8054426312446594,
-0.150490865111351,
-0.9087026715278625,
-0.4663776159286499,
-0.2182464301586151,
-0.7075991630554199,
-0.5350576639175415,
-0.9372857213020325,
-0.11118857562541962,
0.42173826694488525,
0.42109450697898865,
-0.45557907223701477,
0.13803555071353912,
-0.026730237528681755,
0.28437697887420654,
-0.037931520491838455,
-0.02178138680756092,
1.5651650428771973,
0.06233357638120651,
-0.2172507643699646,
-0.49868378043174744,
0.49909353256225586,
-0.7537012100219727,
-0.5043044686317444,
-0.8812752366065979,
0.1210709884762764,
0.42529189586639404,
-0.3989110589027405,
-0.5656257271766663,
0.17275410890579224,
0.3175260126590729,
1.1447947025299072,
-0.8435484170913696,
-0.20032425224781036,
0.19904470443725586,
0.0092118876054883,
0.19591139256954193,
-0.08712620288133621,
-0.7108457088470459,
0.2915664315223694,
0.4972427785396576,
-0.12621992826461792,
-0.10422716289758682,
0.07822719216346741,
-0.35801398754119873,
1.0540982484817505,
0.01894228905439377,
-0.742957592010498,
1.1897879838943481,
0.5023890137672424,
-0.10519199073314667,
0.7623721957206726,
-1.004068374633789,
0.49037280678749084,
0.48094454407691956,
-0.26258358359336853,
-0.6556510329246521,
-0.18862080574035645,
-0.5549305081367493,
-1.2737014293670654,
-0.42176926136016846,
0.18176217377185822,
-0.48340466618537903,
-0.5878879427909851,
0.43451225757598877,
0.7949496507644653,
0.2056131362915039,
-0.2522415220737457,
0.08797817677259445,
-0.35102981328964233,
0.9360284805297852,
-0.5945693850517273,
-0.07392419129610062,
-0.5654339790344238,
-1.2849960327148438,
0.17896583676338196,
0.007861386984586716,
0.04507526755332947,
0.2269294708967209,
-0.6969941258430481,
0.8431044816970825,
0.4276100695133209,
0.304903119802475,
0.1127300038933754,
0.41883584856987,
-0.351844847202301,
0.9994456768035889,
0.31640222668647766,
-0.10784687101840973,
0.37951213121414185,
0.4318316876888275,
-0.37769028544425964,
0.9577241539955139,
-0.22399194538593292,
-0.20351915061473846,
0.43954798579216003,
0.2524279057979584,
-0.5198213458061218,
-0.49541008472442627,
0.15852800011634827,
-0.1210254356265068,
-0.2017090618610382,
0.030843360349535942,
0.6465747356414795,
0.7636286616325378,
-0.1668495088815689,
0.9297593235969543,
-0.5751805901527405,
-0.3387936055660248,
-0.47634387016296387,
-0.30972036719322205,
0.9905769228935242,
-0.09960372000932693,
-0.1002572625875473,
-0.32314053177833557,
-0.08332164585590363,
0.4443165063858032,
-0.8031774759292603,
0.5143062472343445,
-0.17941470444202423,
-0.5673786401748657,
-0.5374671816825867,
0.2916843891143799,
0.09069792926311493,
-0.4592570960521698,
-0.24267345666885376,
1.1191664934158325,
0.028917180374264717,
-0.9246469140052795,
0.7861757874488831,
0.9972002506256104,
-0.6090745329856873,
1.6700611114501953,
-0.30507081747055054,
0.6731324195861816,
-0.11785217374563217,
-0.920028030872345,
-0.7553226351737976,
0.33908820152282715,
-0.5853277444839478,
0.2984139919281006,
-0.691149115562439,
-0.5421887636184692,
0.01023442205041647,
-0.3820493519306183,
0.04182090982794762,
-0.23660288751125336,
0.11100000143051147,
0.2711407542228699,
0.4871947467327118,
0.36202359199523926,
0.03362857922911644,
-0.3906153440475464,
-0.705880343914032,
1.076443076133728,
-0.21025769412517548,
0.2103772908449173,
-0.5064977407455444,
-0.40344586968421936,
0.62631756067276,
-0.043450579047203064,
-0.19198045134544373,
1.0175495147705078,
-0.10489935427904129,
0.5033178925514221,
1.1017451286315918,
0.42097246646881104,
0.3409360349178314,
0.4365638792514801,
0.12513995170593262,
-0.6293894052505493,
0.21782493591308594,
0.643742024898529,
-0.3409273326396942,
1.2960182428359985,
0.18236151337623596,
-0.38888049125671387,
-0.42149391770362854,
0.115696482360363,
0.43740102648735046,
0.7523968815803528,
0.41199132800102234,
0.2099914699792862,
-0.9692382216453552,
-0.4305545389652252,
-0.48783624172210693,
0.39636141061782837,
0.29919713735580444,
-1.022132158279419,
-0.9795168042182922,
0.6409072279930115,
0.13694408535957336,
-0.1275307536125183,
-0.005081471987068653,
0.2658497989177704,
-0.15200312435626984,
1.0629019737243652,
-1.443609356880188,
0.5068143010139465,
0.04468229413032532,
-0.4712004065513611,
-0.278788685798645,
0.22588728368282318,
-0.09683002531528473,
-0.425192654132843,
-0.5932456254959106,
0.4893124997615814,
-0.4290742874145508,
-0.49877673387527466,
0.31369727849960327,
0.0014851702144369483,
0.3790770471096039,
-0.3768538236618042,
0.4025319814682007,
0.14138557016849518,
-0.09824118763208389,
0.47151482105255127,
0.5305824875831604,
0.5892608165740967,
0.07175834476947784,
1.4848735332489014,
-0.13310597836971283,
1.174959659576416,
0.025477232411503792,
-0.24864701926708221,
-0.08132647722959518,
0.5729189515113831,
0.33712610602378845,
0.7092764973640442,
0.0043465206399559975,
-0.7518514394760132,
0.9923071265220642,
0.695805549621582,
0.05234985053539276,
-0.01576758734881878,
0.2585156559944153,
0.4111790955066681,
-0.12778642773628235,
0.1243777871131897,
-0.6088906526565552,
0.6383070945739746,
0.34575963020324707,
0.38964635133743286,
-0.45003843307495117,
-0.2471807897090912,
0.025033578276634216,
0.17718857526779175,
-0.5402860045433044,
-0.6659700274467468,
-0.5969005227088928,
0.017509210854768753,
0.4075663983821869,
0.8232964277267456,
0.4159257113933563,
0.6841403245925903,
-0.08288729190826416,
0.6018903851509094,
-0.3774922788143158,
0.33055800199508667,
-1.0906736850738525,
-1.191620111465454,
-1.2472927570343018,
-0.048877157270908356,
-0.7705069184303284,
-0.551682710647583,
0.5045944452285767,
-0.6412206292152405,
0.8060719966888428,
0.20529939234256744,
0.3487091064453125,
-0.237351194024086,
0.14379999041557312,
0.22314809262752533,
0.26758208870887756,
0.37529680132865906,
-0.3712865114212036,
1.3157912492752075,
-0.37056592106819153,
0.4561861455440521,
-0.5543891787528992,
0.04882974550127983,
-0.19410626590251923,
-0.3478471636772156,
0.23147834837436676,
0.21461983025074005,
-0.11862874776124954,
-0.38104939460754395,
-0.054523538798093796,
-0.5582645535469055,
-0.6051791906356812,
0.2962285578250885,
0.13669027388095856,
-0.8083404898643494,
-0.8791484832763672,
0.9155510663986206,
0.5852853655815125,
-0.5699771046638489,
0.4739401936531067,
1.0538578033447266,
-0.5730319619178772,
0.45444798469543457,
0.24898666143417358,
0.09273449331521988,
-1.095772385597229,
-0.21254147589206696,
0.9261655211448669,
-0.08319883048534393,
0.043206240981817245,
-0.982640266418457,
-1.5211292505264282,
-0.1998441517353058,
0.4060102105140686,
-0.16807067394256592,
0.04161026328802109,
0.7768267393112183,
0.15561145544052124,
-1.4381992816925049,
0.9844973683357239,
-0.02132958546280861,
-1.1707727909088135,
0.2517569065093994,
0.11729103326797485,
-0.03639515861868858,
0.4871852397918701,
-0.1472810059785843,
-0.2851735055446625,
-0.24393238127231598,
-0.0871066004037857,
0.6104415655136108,
0.2566399574279785,
-0.6632923483848572,
0.18775856494903564,
1.46880304813385,
1.102675437927246,
-0.2188982218503952,
0.5565428137779236,
0.4641689658164978,
0.2777203321456909,
-0.12972521781921387,
-0.39316248893737793,
0.3677257001399994,
0.7734780311584473,
0.18101000785827637,
0.034329961985349655,
0.5976153612136841,
-0.12437767535448074,
-0.06449428200721741,
0.211747407913208,
-0.260529100894928,
0.6291605234146118,
0.7653433680534363,
0.12616650760173798,
-0.2699165344238281,
-0.16387294232845306,
-1.1452903747558594,
-0.1051454171538353,
0.2634311020374298,
0.3212553858757019,
-0.999818742275238,
0.2819483280181885,
0.38034847378730774,
0.0008347871480509639,
0.855414092540741,
0.024933485314249992,
-0.5958737730979919,
0.38393405079841614,
-0.4319291412830353,
1.17889404296875,
-0.8573806285858154,
0.2002367526292801,
0.3082301914691925,
0.6695239543914795,
0.44567784667015076,
0.5589253306388855,
0.5662932395935059,
-0.25129246711730957,
-0.4700487554073334,
-0.5136142373085022,
0.27184873819351196,
0.2107805460691452,
-0.05013545975089073,
-0.06551390141248703,
-0.01703779213130474,
-0.6448323130607605,
-0.1763480305671692,
0.4932093620300293,
-0.11641619354486465,
-0.14248035848140717,
0.049414679408073425,
0.24808810651302338,
-0.37003785371780396,
0.6503636837005615,
0.11725562065839767,
0.7341572046279907,
0.006394743453711271,
-1.109098196029663,
-0.22197405993938446,
0.26081061363220215,
-0.8839712142944336,
0.12695889174938202,
-0.3937939405441284,
0.005121480207890272,
0.34598997235298157,
-0.22242143750190735,
0.32858017086982727,
-0.3396071195602417,
0.04082696512341499,
-0.0957464724779129,
0.6243420243263245,
0.37518441677093506,
-0.18203940987586975,
-0.9941561818122864,
0.41129255294799805,
0.25220343470573425,
-0.38699111342430115,
0.2064984291791916,
-0.46753108501434326,
0.06252981722354889,
0.4415391683578491,
-0.3552398383617401,
-0.7696593999862671,
-0.21031486988067627,
-0.2609928548336029,
-0.05818527936935425,
0.3259519338607788,
0.4349110424518585,
-0.33391204476356506,
-0.022417599335312843,
-0.47440794110298157,
-0.11408691853284836,
0.0377996452152729,
0.17935633659362793,
-0.31512317061424255,
-0.33535629510879517,
-0.3899633586406708,
0.07026258111000061,
0.6742405295372009,
0.21575045585632324,
-0.823425829410553,
0.14169450104236603,
-0.8256228566169739,
0.46468934416770935,
-0.48413822054862976,
0.490930438041687,
0.13580426573753357,
-0.2147354781627655,
-0.2111450433731079,
-0.17493626475334167,
0.254387229681015,
0.25315484404563904,
-0.16903968155384064,
0.17224888503551483,
-0.14389708638191223,
-1.0444726943969727,
1.0493075847625732,
0.013943818397819996,
-0.2082809954881668,
0.90952068567276,
0.2533416450023651,
-0.06332121789455414,
-0.14372101426124573,
0.534506618976593,
-0.8455788493156433,
1.246488094329834,
-0.37021493911743164,
0.5160751938819885,
-0.3046337068080902,
-0.784675657749176,
0.13196367025375366,
-0.5529154539108276,
0.22807419300079346,
-0.4788424074649811,
-1.2857496738433838,
0.23338788747787476,
-0.6399523019790649,
-0.27106747031211853,
0.6009339690208435,
-0.8821097612380981,
0.18151476979255676,
0.23569725453853607,
-0.9621173739433289,
0.5376750826835632,
-0.6857378482818604,
0.23999720811843872,
-0.3046279847621918,
-0.29010772705078125,
-0.5037626624107361,
0.8397530317306519,
-0.042811375111341476,
1.5577305555343628,
-0.727344810962677,
-0.9133148193359375,
0.18894769251346588,
0.17719630897045135,
-0.10836470872163773,
-0.6018436551094055,
-0.17164644598960876,
0.25340861082077026,
0.06241122633218765,
0.15216417610645294,
-0.4447992444038391,
-0.0592518225312233,
0.09239782392978668,
0.0213311780244112,
0.08109163492918015,
0.07571085542440414,
0.06629689782857895,
-0.6004220247268677,
0.3435608446598053,
0.49627670645713806,
-1.4875332117080688,
-1.0125904083251953,
0.644300103187561,
0.1117294430732727,
0.020697621628642082,
0.39414921402931213,
-0.7825215458869934,
0.4801133871078491,
-0.6550092697143555,
0.4972684383392334,
-0.649049699306488,
-0.17869414389133453,
-1.2604103088378906,
-0.40015751123428345,
-0.4524063169956207,
0.015953553840517998,
0.17845840752124786,
-0.8375637531280518,
-1.1803295612335205,
-0.7184408903121948,
0.09642109274864197,
-0.3930346965789795,
-0.6029123663902283,
-1.4067806005477905,
0.16617588698863983,
0.4827187657356262,
-0.027415789663791656,
-0.2510544955730438,
-0.3504752814769745,
-0.12296637892723083,
-0.15711374580860138,
0.3034510016441345,
0.34677016735076904,
-0.9623921513557434,
-0.5781219601631165,
-0.15896449983119965,
-0.08030300587415695,
0.08664734661579132,
0.5092716217041016,
-1.2339216470718384,
0.3436388671398163,
-0.9714227914810181,
-0.7977949380874634,
-0.1916046291589737,
0.07318081706762314,
0.46654757857322693,
0.2992904484272003,
1.046452283859253,
0.35736513137817383,
0.30223625898361206,
-0.06763637065887451,
0.595363438129425,
-0.2625062167644501,
-0.10255666822195053,
-0.8087462186813354,
-0.5212163925170898,
-1.2338846921920776,
-1.2140910625457764,
0.14555472135543823,
-1.17864990234375,
-0.6494525671005249,
-0.43381476402282715,
0.4262206554412842,
0.49368056654930115,
-0.0027462318539619446,
0.8940141201019287,
0.7745542526245117,
0.6729252934455872,
-0.02592092752456665,
0.7715246081352234,
-0.18815836310386658,
0.02656104415655136,
-0.8747095465660095,
-0.019984034821391106,
-0.08402152359485626,
-0.5595748424530029,
0.44185084104537964,
-0.6429117321968079,
-0.9629093408584595,
0.2830064594745636,
-0.001577530289068818,
0.13319480419158936,
-0.16941644251346588,
-0.06852694600820541,
-0.11858118325471878,
0.005717911757528782,
-0.5244249701499939,
0.16678525507450104,
-0.03667321428656578,
-0.16310720145702362,
1.1565717458724976,
0.2820731997489929,
0.742279052734375,
0.2821754813194275,
-0.23735672235488892,
0.21476717293262482,
-0.3757351040840149,
0.9588249325752258,
-0.4937022626399994,
-0.9450275897979736,
-0.3852560222148895,
0.2752097249031067,
-0.8869895935058594,
-0.7086926698684692,
-0.2816963493824005,
-0.2750154435634613,
0.3017737567424774,
-0.5215560793876648,
0.36215195059776306,
0.3425259590148926,
-0.2498912811279297,
-0.4018746614456177,
0.03287237510085106,
-0.36069563031196594,
-0.06015203148126602,
-0.15498913824558258,
0.29061615467071533,
-0.9103820323944092,
1.1173021793365479,
0.9074724912643433,
-0.3379918038845062,
-0.5145496726036072,
-0.910862386226654,
0.514499843120575,
0.2590774893760681,
-0.04805920273065567,
0.2877267599105835,
-0.023997312411665916,
-0.16156810522079468,
0.05830533802509308,
0.7412335276603699,
-0.38433417677879333,
-0.11924421042203903,
-0.32085302472114563,
0.8584468364715576,
0.1930239051580429,
-0.25781670212745667,
-0.8242636322975159,
0.5130847096443176,
0.3189193606376648,
0.01913497969508171,
0.5084649324417114,
0.5289170145988464,
1.1544380187988281,
0.3004911541938782,
0.10573422908782959,
-1.3819973468780518,
0.18162132799625397,
-1.4409794807434082,
0.08107181638479233,
-0.15697726607322693,
-0.6132532358169556,
-0.522731363773346,
0.01666693575680256,
0.21075494587421417,
-0.11315486580133438,
-0.24372772872447968,
0.3377569317817688,
-0.7742049694061279,
0.26505884528160095,
-0.7402729392051697,
0.2139347940683365,
-1.1722495555877686,
-0.8657268285751343,
0.11106637120246887,
-0.6147745251655579,
0.24332842230796814,
1.3448095321655273,
-0.21433314681053162,
0.0343082994222641,
0.27116256952285767,
0.46368592977523804,
0.5996752977371216,
0.6412034034729004,
-1.2220590114593506,
-0.4191127121448517,
-1.0878113508224487,
0.27961668372154236,
-0.31894153356552124,
0.3889995813369751,
0.677322506904602,
-0.3374769985675812,
0.1306886374950409,
1.1676604747772217,
-0.2505123019218445,
-1.748273491859436,
-0.46644914150238037,
0.6948126554489136,
-0.7015517950057983,
0.4166141450405121,
-0.3374263048171997,
0.9863568544387817,
-0.7662737965583801,
-0.5385423302650452,
-0.3961639404296875,
-0.13525457680225372,
0.06713805347681046,
0.5812471508979797,
0.2934298515319824,
0.7828280329704285,
-0.12344000488519669,
0.5753882527351379,
-0.15704628825187683,
0.2189061939716339,
0.3348478078842163,
-0.20433446764945984,
0.3937948942184448,
0.32373279333114624,
-0.7999578714370728,
-0.7805793881416321,
0.7974662780761719,
0.5411825776100159,
-0.12474120408296585,
-0.8214828968048096,
0.2115907371044159,
0.4488040506839752,
-0.6374503374099731,
0.04483133926987648,
0.5390212535858154,
0.302434504032135,
0.19584953784942627,
-0.3580518960952759,
-0.20031969249248505,
-0.7552382349967957,
-0.5463290214538574,
0.3357190489768982,
-1.1210343837738037,
-0.4406787157058716,
0.37276503443717957,
-0.6651241779327393,
-0.2260541319847107,
-0.5432471036911011,
-0.6773623824119568,
-0.07222595810890198,
0.26881638169288635,
0.85024493932724,
-0.4670290946960449,
0.030249908566474915,
-0.31231173872947693,
0.5645877718925476,
0.16372673213481903,
-0.4872834384441376,
0.07096301764249802,
0.3521253764629364,
-0.5111611485481262,
-0.5368038415908813,
0.46109357476234436,
0.7608106136322021,
-0.016753030940890312,
0.009222117252647877,
0.3055693209171295,
-0.2951710820198059,
0.7817879915237427,
-0.1406095176935196,
-0.1661681979894638,
0.029246598482131958,
-0.6204838752746582,
0.18725354969501495,
-0.5312395095825195,
-0.47232183814048767,
-0.4893154799938202,
0.587052047252655,
0.32684245705604553,
-0.47428593039512634,
-0.9059759378433228,
-0.2605680525302887,
1.1125879287719727,
-0.27545350790023804,
1.3125213384628296,
0.8325497508049011,
0.43312299251556396,
-0.2187284380197525,
-0.9987224340438843,
0.41105350852012634,
0.8470760583877563,
-0.059520140290260315,
0.506073534488678,
-0.6176174879074097,
0.33108067512512207,
0.5165152549743652,
0.38327664136886597,
-0.5173267126083374,
0.27802231907844543,
-0.13582606613636017,
0.30644750595092773,
0.5972552299499512,
-0.018092460930347443,
-0.19582076370716095,
-0.2856864929199219,
-0.08316467702388763,
-0.23992721736431122,
0.45631805062294006,
-0.09474175423383713,
0.7438473701477051,
-0.5726969242095947,
0.658072829246521,
0.3033411204814911,
-1.1018080711364746,
-0.21187105774879456,
-0.042578671127557755,
0.888028621673584,
0.0271880105137825,
-0.374648779630661,
-0.6665101051330566,
0.9497638940811157,
0.6543649435043335,
0.4818161427974701,
0.8507298231124878,
-0.004975501447916031,
-0.0887998417019844,
-0.9913824200630188,
0.6831207275390625,
0.05683479830622673,
0.7883443236351013,
-0.17835275828838348,
-0.707587718963623,
-0.8699676394462585,
0.9154382348060608,
-0.636848509311676,
-1.1347788572311401,
0.8281399011611938,
-0.030731577426195145,
-0.2641243636608124,
-0.08664115518331528,
-0.07430224120616913,
-0.36435529589653015,
0.43674135208129883,
0.950049102306366,
-0.5198848247528076,
-0.5573592185974121,
0.5859750509262085,
-0.6450327634811401,
0.5896960496902466,
1.1720385551452637,
0.7686605453491211,
-0.3435082733631134,
1.8194881677627563,
0.5852762460708618,
0.4347711503505707,
0.7314863204956055,
0.1964273452758789,
-0.05646052211523056,
0.014310533180832863,
-0.27146682143211365,
-0.1154065877199173,
0.16358499228954315,
-0.18883901834487915,
-0.4955834150314331,
0.22264720499515533,
0.061480168253183365,
-0.7428188323974609,
0.3849979639053345,
-0.15225006639957428,
0.21752861142158508,
-0.8543834090232849,
-0.46669304370880127,
0.4329608976840973,
0.5508097410202026,
-0.20749424397945404,
-0.19825254380702972,
0.04877978190779686,
-0.3950001001358032,
0.3941044509410858,
-1.153914213180542,
0.4854419529438019,
0.4340950846672058,
-0.45694077014923096,
0.10452210903167725,
-0.833159327507019,
-0.7723588943481445,
-0.07685999572277069,
-0.6254205703735352,
-0.4759353995323181,
0.5396941304206848,
0.6193956732749939,
0.46145692467689514,
0.15657497942447662,
-0.6047462224960327,
0.23795966804027557,
0.4484694004058838,
0.40818119049072266,
-0.09934363514184952,
0.3566417694091797,
0.663286030292511,
0.5335472226142883,
-0.005051326937973499,
0.05987635999917984,
-0.4719015955924988,
-0.20346790552139282,
0.22565825283527374,
-0.6722548007965088,
-0.09311746060848236,
-0.22121132910251617,
-1.028326392173767,
0.5249809622764587,
0.9714956879615784,
-0.5620169639587402,
-0.4513874053955078,
-0.2929277718067169,
0.5297595858573914,
-0.6908418536186218,
0.05723094195127487,
-0.6723954677581787,
0.5999072790145874,
-0.10765934735536575,
-0.6238991022109985,
-0.16818323731422424,
-0.8562041521072388,
3.721407651901245,
1.2312318086624146,
0.6022018194198608,
0.8975178003311157,
0.46786195039749146,
0.7230760455131531,
0.4063614010810852,
-1.2690565586090088,
0.18614119291305542,
0.18508729338645935,
-0.18617163598537445,
0.012569807469844818,
0.06788752973079681,
0.5644375681877136,
-0.6017526984214783,
0.2772614657878876,
-1.1535900831222534,
0.4472619593143463,
-0.1035950556397438,
-0.5955580472946167,
-0.9341285824775696,
0.46350613236427307,
0.026598263531923294,
-0.8518800735473633,
0.1300199329853058,
-0.015553838573396206,
-0.3400622308254242,
0.028135275468230247,
-0.1799258291721344,
0.21074989438056946,
0.5046114325523376,
-0.2426041066646576,
0.23645193874835968,
-0.08620578795671463,
0.32466834783554077,
0.14570194482803345,
0.31322798132896423,
-0.532906174659729,
0.03380603343248367,
0.5184011459350586,
0.10041722655296326,
0.19716666638851166,
0.09759926050901413,
0.25469258427619934,
-0.4755392074584961,
0.5993012189865112,
-0.47064462304115295,
0.04888840392231941,
1.420325517654419,
-1.0228437185287476,
0.12943817675113678,
-0.907442569732666,
0.8122870922088623,
-0.5454314947128296,
-0.6726944446563721,
-0.48072007298469543,
-0.17926159501075745,
-0.5278710126876831,
-0.33255821466445923,
0.5583371520042419,
0.15138015151023865,
-0.1580560803413391,
-0.05749203637242317,
-0.05464712902903557,
-0.18178142607212067,
0.31785091757774353,
0.7114973664283752,
-0.006235318258404732,
0.13342522084712982,
-0.3332240879535675,
0.11218402534723282,
-0.4546594023704529,
0.20515233278274536,
-0.14496122300624847,
0.9972063899040222,
0.3719382584095001,
-0.6019617319107056,
0.7286216020584106,
0.30362141132354736,
-0.04958374798297882,
0.5092387199401855,
-0.6108855605125427,
-0.12490334361791611,
-0.14174655079841614,
0.5027347207069397,
0.054382484406232834,
-0.1958647221326828,
0.826919436454773,
0.07969994843006134,
0.5775308609008789,
0.8615865111351013,
0.35069161653518677,
0.7435552477836609,
-0.4761868715286255,
0.18069908022880554
] | {"Title": "Divide and Conquer approach for Genome Classification based on subclass characterization", "Authors": "Patil S.S., Murty M.N., Angadi U.B.", "Abstract": "Abstract Classification of large grass genome sequences has major challenges in functional genomes. The presence of motifs in grass genome chains can make the prediction of the functional behavior of grass genome possible. The correlation between grass genome properties and their motifs is not always obvious, since more than one motif may exist within a genome chain. Due to the complexity of this association most pattern classification algorithms are either vain or time consuming. Attempted to a reduction of high dimensional data that utilizes DAC technique is presented. Data are disjoining into equal multiple sets while preserving the original data distribution in each set. Then, multiple modules are created by using the data sets as independent training sets and classified into respective modules. Finally, the modules are combined to produce the final classification rules, containing all the previously extracted information. The methodology is tested using various grass genome data sets. Results indicate that the time efficiency of our algorithm is improved compared to other known data mining algorithms.", "URL": "https://doi.org/10.1101/003475"} |
10.1101/2020.03.24.005587 | [
-0.13019424676895142,
0.47606611251831055,
0.37527164816856384,
-0.06617535650730133,
0.567586362361908,
0.17186295986175537,
-0.7864209413528442,
0.0148765342310071,
-0.014570332132279873,
1.1505471467971802,
-0.025484725832939148,
-0.660639226436615,
0.11421417444944382,
-0.7656442523002625,
-0.299228698015213,
-0.094521164894104,
-0.04749412462115288,
-0.0694865956902504,
-0.32085341215133667,
-0.6827899813652039,
0.23860925436019897,
0.45758122205734253,
-1.039688229560852,
-0.0067535871639847755,
-0.608611524105072,
1.1413787603378296,
0.12955309450626373,
0.3600753843784332,
1.4957265853881836,
0.5482788681983948,
0.35438400506973267,
-0.2524539828300476,
0.2913351058959961,
-1.038933515548706,
-0.27915555238723755,
-0.28064486384391785,
0.7796627283096313,
-0.25605496764183044,
-0.08781084418296814,
-0.6392311453819275,
0.47271835803985596,
0.15779562294483185,
0.21006038784980774,
-0.09894666075706482,
-0.3597666621208191,
0.4221073389053345,
0.012427753768861294,
0.2863028645515442,
-0.1593279391527176,
-0.6092514991760254,
-0.0026795738376677036,
-0.04723048210144043,
0.11494002491235733,
-0.1848534792661667,
-0.2950872778892517,
-0.6854618191719055,
0.3431573808193207,
0.1617579460144043,
0.08778398483991623,
-0.0834256261587143,
0.31040242314338684,
0.23709268867969513,
0.1424584686756134,
-0.6707862019538879,
1.0377260446548462,
1.1327898502349854,
-0.07424478232860565,
-0.6114533543586731,
0.05889110639691353,
-0.3339002728462219,
-0.7502121329307556,
-0.9507690072059631,
-0.1078653484582901,
-0.37245962023735046,
-0.7329934239387512,
0.5481285452842712,
0.0005174515536054969,
-0.11881101876497269,
-0.14860710501670837,
-0.20020000636577606,
0.17259755730628967,
0.3622996211051941,
-0.0014202852034941316,
0.28917941451072693,
-1.1065266132354736,
0.3813900947570801,
0.49858832359313965,
1.5091270208358765,
0.5169556736946106,
0.7163639664649963,
-0.39446142315864563,
0.2222164124250412,
-0.03563621640205383,
-0.12156417220830917,
0.656987726688385,
1.0163179636001587,
-0.9356606602668762,
0.1853475421667099,
0.18640124797821045,
-0.2229529470205307,
1.052801489830017,
0.6893520951271057,
-0.24604733288288116,
1.3575239181518555,
-0.4814644455909729,
1.1716923713684082,
1.4448281526565552,
0.09060058742761612,
-1.1556097269058228,
-0.39593586325645447,
0.4565345346927643,
-0.2841990292072296,
-0.8968634605407715,
-0.18220467865467072,
1.0624852180480957,
0.3824869990348816,
0.11125092953443527,
0.2642730474472046,
-0.7470136284828186,
-0.23431868851184845,
0.34472185373306274,
-0.33421221375465393,
0.4027974307537079,
-0.33091843128204346,
0.03877915069460869,
0.1385844647884369,
-0.4779473841190338,
0.5608358383178711,
-0.4078206717967987,
0.07699167728424072,
-0.7302460074424744,
-1.2242785692214966,
0.13088086247444153,
0.32896146178245544,
-0.09481285512447357,
-0.2380247265100479,
-0.5198314785957336,
1.3348946571350098,
0.4528811275959015,
-0.3511061668395996,
0.5001475811004639,
0.9391105771064758,
-0.8996493816375732,
1.64356529712677,
-0.11502880603075027,
0.4939967393875122,
-0.3690634071826935,
-1.516205072402954,
0.3301298916339874,
0.3593114912509918,
0.04908011481165886,
0.5100942254066467,
-0.01143419835716486,
-0.11899404972791672,
-0.6042124032974243,
0.6217346787452698,
-0.46284329891204834,
0.23234978318214417,
0.042793285101652145,
-0.25923892855644226,
-0.29074111580848694,
-0.7167619466781616,
0.09287448972463608,
0.8905442953109741,
-0.1564759612083435,
1.1658411026000977,
-0.6681355834007263,
0.43308940529823303,
-0.24237793684005737,
-0.7092587947845459,
0.895228922367096,
0.25400206446647644,
-0.34055444598197937,
0.6134482026100159,
-0.030979296192526817,
0.5614741444587708,
0.32183048129081726,
-0.14665085077285767,
-0.006258117966353893,
0.3621372580528259,
-0.1795423924922943,
-0.5597664713859558,
-0.4481380581855774,
0.4688328504562378,
0.0981704369187355,
-0.18051061034202576,
0.15569782257080078,
-0.6377782821655273,
-0.12633226811885834,
-0.759099543094635,
0.30716967582702637,
0.8805227279663086,
-0.8259878754615784,
0.4340604245662689,
-0.5438006520271301,
0.19784274697303772,
0.18152719736099243,
1.4268113374710083,
0.3368045389652252,
-0.22107526659965515,
-0.6132656335830688,
0.9947866797447205,
-0.8819016218185425,
0.25895822048187256,
-0.6600364446640015,
0.8352499008178711,
-0.04924173653125763,
0.5925827026367188,
-0.49779826402664185,
0.31141430139541626,
0.18559949100017548,
-0.3517932593822479,
-0.05882640182971954,
-0.3528936803340912,
-0.6489972472190857,
-1.0437616109848022,
0.4644516706466675,
0.951768696308136,
0.02833816222846508,
-0.4381255507469177,
0.4535766541957855,
-0.4626356363296509,
0.5746691823005676,
0.04956774786114693,
0.48779526352882385,
0.8469870686531067,
0.6795244216918945,
0.705857515335083,
-0.027313506230711937,
0.6328551769256592,
-0.02098321169614792,
1.2923502922058105,
-0.2452763468027115,
0.734548032283783,
0.31646034121513367,
0.28729507327079773,
0.6810280084609985,
0.3802811801433563,
-0.4708913564682007,
0.16053207218647003,
1.0400457382202148,
0.3475605547428131,
0.5188694596290588,
0.5281729102134705,
-0.040373723953962326,
0.38993528485298157,
0.6375780701637268,
1.001758098602295,
-0.9562458395957947,
0.9449989199638367,
-0.8419255018234253,
0.774368405342102,
0.9220117926597595,
0.1686975061893463,
-1.0749201774597168,
-0.33788400888442993,
-0.09436284750699997,
0.09515228122472763,
-0.17592163383960724,
-0.15662527084350586,
-0.5249807834625244,
0.2750435769557953,
0.5021504163742065,
0.25902676582336426,
0.12156902998685837,
0.4215991199016571,
-0.21537768840789795,
0.26061132550239563,
-0.2692965269088745,
0.019648399204015732,
-1.435046911239624,
-0.36335763335227966,
-0.8275096416473389,
-1.0460795164108276,
-1.0012043714523315,
-0.03333624079823494,
-0.37640076875686646,
-0.21283693611621857,
0.28840371966362,
0.28187134861946106,
-0.446781724691391,
-0.44842973351478577,
0.09041166305541992,
0.5154415965080261,
0.4221692383289337,
0.18388456106185913,
-0.9731025099754333,
1.112601637840271,
-0.46270060539245605,
-0.3585840165615082,
-0.6621642112731934,
-0.2950984835624695,
-0.5502100586891174,
-0.5412815809249878,
-0.09697083383798599,
0.028678735718131065,
0.4381233751773834,
0.09375762939453125,
-0.2171182483434677,
-0.6272909045219421,
-0.024638846516609192,
-0.1323930025100708,
0.3928191065788269,
0.06293542683124542,
-0.9707306623458862,
1.1578878164291382,
0.12372779101133347,
0.19819699227809906,
0.6662693023681641,
0.21045637130737305,
0.11830820888280869,
0.6451056003570557,
-0.18565024435520172,
0.20353807508945465,
-1.1297485828399658,
0.44180747866630554,
0.39284202456474304,
0.6860887408256531,
0.2856466472148895,
-0.9603659510612488,
-0.9877623915672302,
0.11305660009384155,
0.04199148714542389,
-0.9353213310241699,
0.029460210353136063,
1.1270039081573486,
0.21340373158454895,
-1.3411192893981934,
0.9253016710281372,
-0.38019463419914246,
-0.3351190984249115,
-0.07905121147632599,
0.2147480547428131,
1.293533444404602,
0.7892881035804749,
0.22739265859127045,
-0.2538425326347351,
0.14970360696315765,
-0.4626545310020447,
1.0609467029571533,
0.4184626340866089,
-0.07876067608594894,
0.09447305649518967,
0.17758354544639587,
0.4893229603767395,
0.35315799713134766,
0.8923280239105225,
0.1307753175497055,
0.24472126364707947,
0.44846588373184204,
-0.45055022835731506,
0.3847717046737671,
0.803887665271759,
0.24831423163414001,
-0.5333259105682373,
0.20190979540348053,
-0.2893180549144745,
-0.21977566182613373,
0.04672930762171745,
0.06455625593662262,
-0.3249301314353943,
-0.5990777015686035,
-0.5875879526138306,
-0.17898769676685333,
-0.8047693371772766,
-0.7739406228065491,
0.14019599556922913,
-0.15812565386295319,
0.40168899297714233,
-0.265639066696167,
0.5903679728507996,
0.11869636923074722,
-0.8193052411079407,
0.4233708083629608,
-0.3896108865737915,
-0.44230425357818604,
0.33404120802879333,
0.5790284872055054,
1.2437585592269897,
-1.1570160388946533,
-0.714999794960022,
-0.7021616101264954,
0.4741983115673065,
0.5798417925834656,
0.3919687867164612,
0.6537833213806152,
-0.7102266550064087,
-0.015124311670660973,
-0.24861980974674225,
-0.21460123360157013,
-0.024331524968147278,
-0.29533469676971436,
0.09687115997076035,
0.1558820754289627,
-0.8972579836845398,
-0.05566462501883507,
0.709121823310852,
1.0756911039352417,
-0.3967472016811371,
0.46696344017982483,
0.8561307191848755,
-0.3244614899158478,
0.29753589630126953,
0.8454310894012451,
0.9236500859260559,
0.7441245913505554,
-0.7686681747436523,
0.14466355741024017,
0.051115527749061584,
-0.6361600756645203,
-0.12457970529794693,
-0.5978532433509827,
-0.27947553992271423,
-0.2826077342033386,
0.40940579771995544,
0.6507007479667664,
-0.15924905240535736,
0.09906473010778427,
-0.4508979022502899,
-0.22500798106193542,
0.09401427954435349,
0.06281483173370361,
-0.5675235390663147,
-0.06428927183151245,
0.25740429759025574,
-0.9842535257339478,
-0.27496537566185,
-0.4737176299095154,
1.1105097532272339,
1.1882359981536865,
-1.1887097358703613,
-0.9351112246513367,
-0.23385442793369293,
-0.5806884169578552,
-0.4565335214138031,
0.8152097463607788,
0.04617845639586449,
-0.5203280448913574,
0.43182867765426636,
-0.2239578664302826,
-0.23252813518047333,
0.10568782687187195,
-0.6176456212997437,
-0.42466607689857483,
-0.19771449267864227,
0.4706991910934448,
0.5169237852096558,
0.9306548237800598,
0.5578532814979553,
-0.3629555404186249,
0.2158774584531784,
-0.5001344084739685,
0.13474228978157043,
-0.7098174095153809,
-0.05919838696718216,
0.5222249031066895,
0.16517557203769684,
0.025291554629802704,
0.601870059967041,
-0.0668533444404602,
0.059454429894685745,
-0.41927632689476013,
-0.3233407437801361,
-0.7970215082168579,
-0.6396980285644531,
0.8087849617004395,
-0.0936444103717804,
0.2823510468006134,
0.9636943340301514,
0.43412256240844727,
-0.17287617921829224,
-0.23391282558441162,
0.36817413568496704,
-0.913478672504425,
0.553497850894928,
-0.260894238948822,
-0.019350383430719376,
0.7610979080200195,
-0.2652287483215332,
-0.0396636463701725,
0.1612686961889267,
0.3620355725288391,
-0.42566272616386414,
0.04522642120718956,
0.1664494425058365,
-0.3538239300251007,
-0.5531384944915771,
-0.2256471812725067,
-0.6903066039085388,
-0.23194636404514313,
-0.09663855284452438,
-0.3363436758518219,
-0.06607797741889954,
0.23582905530929565,
0.028466062620282173,
-0.5281039476394653,
0.1422795206308365,
0.4652661085128784,
-0.14672981202602386,
0.725918173789978,
0.7431516051292419,
0.1852627545595169,
-1.2194101810455322,
0.3823320269584656,
-0.0414457842707634,
-0.2694667875766754,
-0.3824816644191742,
-0.5568516850471497,
0.004560698755085468,
-0.5557336211204529,
-0.27545711398124695,
-0.5846229195594788,
0.19579316675662994,
-0.28702300786972046,
0.1723778396844864,
0.16766270995140076,
-0.18403752148151398,
0.24657797813415527,
0.09148580580949783,
0.35452142357826233,
-0.08312872797250748,
-0.9988587498664856,
-0.288983017206192,
0.7484786510467529,
-0.6818453073501587,
-0.10985817760229111,
-0.24965184926986694,
-0.7731451988220215,
0.29015687108039856,
-0.8122484087944031,
0.3798256516456604,
-1.0175997018814087,
0.11208910495042801,
-0.7552968263626099,
-0.8331955075263977,
-0.5422497987747192,
0.734318733215332,
0.2882155478000641,
-0.7667170166969299,
-0.36852046847343445,
-1.185599684715271,
-0.45812514424324036,
-0.1356416642665863,
-1.1846716403961182,
-0.3465839922428131,
-0.1987888216972351,
0.06044536083936691,
0.8180566430091858,
-0.6013997793197632,
-0.6811172366142273,
0.18634754419326782,
0.4388025999069214,
0.5299853682518005,
0.3608414828777313,
-0.5303665399551392,
-0.258994460105896,
-0.18557633459568024,
0.383527010679245,
-0.0969804897904396,
0.9311069250106812,
-0.8630802631378174,
-0.1434609591960907,
-0.5588717460632324,
0.36496177315711975,
-0.14477327466011047,
0.19591070711612701,
0.5881407856941223,
-0.4694680869579315,
1.0748142004013062,
-0.5982055068016052,
-0.4053836166858673,
0.3477069139480591,
0.3756576180458069,
0.04857305809855461,
0.8859673738479614,
-0.49596360325813293,
-0.20922282338142395,
-1.5643999576568604,
-1.629255771636963,
0.5919685959815979,
-0.4379507899284363,
-0.5575820207595825,
0.14940422773361206,
0.4889942407608032,
0.4839591681957245,
-0.0770668312907219,
1.412671446800232,
0.3225294351577759,
-0.09256473183631897,
-0.2338154911994934,
0.8015281558036804,
-0.02533494122326374,
-0.7092424631118774,
-0.567915678024292,
0.3060641586780548,
-0.331670343875885,
-0.5298158526420593,
-0.31308501958847046,
-0.5808097124099731,
-1.388673186302185,
0.0363810732960701,
-0.04146326333284378,
0.6801311373710632,
-0.2862831950187683,
0.20400352776050568,
0.7252550721168518,
-0.41272854804992676,
-0.5352465510368347,
0.04825887084007263,
0.04199914634227753,
0.419674813747406,
0.5035532116889954,
-0.5951758027076721,
0.2214130312204361,
-0.05838455259799957,
0.213296040892601,
-0.062038619071245193,
-0.22465136647224426,
0.6149812936782837,
0.49932777881622314,
-1.1585654020309448,
-0.19927886128425598,
0.336979478597641,
-1.1167124509811401,
-0.37151849269866943,
-0.09484205394983292,
-0.05338077247142792,
0.21230290830135345,
-0.6558277606964111,
-0.2981165647506714,
0.5220469832420349,
-0.2782725691795349,
0.4083297848701477,
0.09877654910087585,
-0.06525950878858566,
0.13938535749912262,
0.0446292906999588,
0.31701087951660156,
-0.6378620862960815,
0.5280347466468811,
1.0590441226959229,
-0.051621053367853165,
-0.09411656111478806,
0.172439843416214,
0.4839748442173004,
0.41169482469558716,
-0.6109597086906433,
0.23527781665325165,
-0.6352243423461914,
0.06491473317146301,
0.299026221036911,
0.634479820728302,
-0.4057997167110443,
-0.17654432356357574,
0.45358607172966003,
0.41352033615112305,
0.3995916545391083,
-1.568481683731079,
-0.3127351701259613,
0.0926596149802208,
0.6647247076034546,
0.306435763835907,
-0.35392841696739197,
0.006673592142760754,
0.18065229058265686,
-0.05526845529675484,
0.17897146940231323,
-1.2687374353408813,
-0.63814777135849,
-1.9618252515792847,
-0.826592206954956,
-0.7267259359359741,
-0.26182395219802856,
0.7135041356086731,
-0.015410327352583408,
0.3973562717437744,
-0.044708941131830215,
-0.6630575656890869,
0.2620968520641327,
-0.10036257654428482,
0.4734508693218231,
-0.9335266351699829,
0.2219432294368744,
-0.5940597653388977,
-0.4565469026565552,
-0.19774211943149567,
-0.40491124987602234,
-0.3757839500904083,
1.1665951013565063,
-0.6993762850761414,
-0.06463601440191269,
0.08872590214014053,
-0.20098164677619934,
-0.1867135763168335,
0.3187752664089203,
-0.5265637636184692,
-0.6788999438285828,
-0.7503494620323181,
0.5399124622344971,
-0.4089253544807434,
-0.08616525679826736,
0.2684766948223114,
-1.077377200126648,
0.15957657992839813,
0.48869025707244873,
-0.2415063977241516,
-1.0494654178619385,
-0.24435950815677643,
0.6179506182670593,
-0.5703652501106262,
-0.12376633286476135,
0.020220184698700905,
0.015157711692154408,
-1.086236596107483,
-0.23720526695251465,
-0.147647887468338,
0.3284341096878052,
0.29804179072380066,
-0.1311436891555786,
0.5480191707611084,
1.0484310388565063,
-0.5131672024726868,
0.4816645681858063,
-0.592101514339447,
0.7969995141029358,
-0.10801200568675995,
-0.34744369983673096,
0.7133341431617737,
-0.11232267320156097,
-0.6284346580505371,
-0.9585866928100586,
0.5237504243850708,
0.8850811123847961,
-0.2938765287399292,
0.2732665240764618,
0.059340279549360275,
0.6235316395759583,
-0.16743998229503632,
-0.715996265411377,
-0.34147465229034424,
1.3463451862335205,
-0.3276951313018799,
-0.18497627973556519,
-0.5245032906532288,
-0.41382327675819397,
-1.0669227838516235,
-0.2641596496105194,
-1.1748380661010742,
-0.1335727870464325,
0.24351471662521362,
-0.3309020400047302,
-0.6928669810295105,
-1.3392118215560913,
-0.18942908942699432,
0.42913922667503357,
0.39752331376075745,
0.9316862225532532,
0.05431288480758667,
-0.0876699686050415,
0.28435444831848145,
0.7991262674331665,
0.360413134098053,
-0.8160894513130188,
0.38285312056541443,
-0.46549662947654724,
-0.20763711631298065,
0.4238419234752655,
0.11654939502477646,
-0.1590200513601303,
-0.17928436398506165,
-0.4492665231227875,
0.12172354757785797,
0.3825817108154297,
0.3773833215236664,
-0.30321523547172546,
-0.3468031585216522,
0.0318375900387764,
-0.5978195667266846,
0.9526646733283997,
-0.30851197242736816,
-0.4433245062828064,
-0.8425060510635376,
0.44952401518821716,
-0.4025825262069702,
-0.5200623273849487,
-0.29536890983581543,
0.36783409118652344,
0.2739495038986206,
-0.3151164948940277,
0.9970908164978027,
0.15985403954982758,
0.558912992477417,
0.11825389415025711,
-0.2234196662902832,
0.361729234457016,
0.24929910898208618,
-0.15645891427993774,
-0.10392597317695618,
0.31682661175727844,
1.0269925594329834,
0.7686065435409546,
0.20345215499401093,
-0.30516043305397034,
0.10070302337408066,
0.38695570826530457,
0.07868453115224838,
-0.08653049170970917,
-0.7184446454048157,
0.4641890823841095,
0.1720655858516693,
0.296243280172348,
0.01176556758582592,
1.1236287355422974,
0.13795851171016693,
0.43619197607040405,
-0.009993835352361202,
-0.2799125611782074,
-0.18587519228458405,
-1.1543177366256714,
-0.15328484773635864,
0.05401407554745674,
0.6483522057533264,
0.3425975441932678,
0.6325428485870361,
0.11929561197757721,
0.8433184623718262,
0.2791576385498047,
0.14885587990283966,
0.9516686201095581,
-0.2829816937446594,
-0.47667092084884644,
-0.8878245949745178,
0.35013043880462646,
0.04804440960288048,
-0.2940464913845062,
0.7597570419311523,
-0.3338747024536133,
0.05173104628920555,
0.42832428216934204,
-1.0293693542480469,
0.06373552232980728,
0.8560721278190613,
-0.07010839879512787,
-0.14397160708904266,
-1.7145642042160034,
0.16988809406757355,
-0.7791610360145569,
0.2021455019712448,
0.305188924074173,
-0.14317819476127625,
-0.5221438407897949,
0.3471603989601135,
0.12855713069438934,
0.887531042098999,
0.7294721603393555,
0.749649167060852,
-0.041389089077711105,
1.1945050954818726,
0.9604495763778687,
0.2554170489311218,
0.2615813612937927,
-0.12628741562366486,
-0.02897229604423046,
-0.22554311156272888,
-0.2801753282546997,
0.07361605763435364,
0.8851234316825867,
-0.6048998236656189,
-0.4030221402645111,
0.4504765570163727,
0.3652194142341614,
-0.5089504718780518,
-0.23785139620304108,
0.3859745264053345,
0.6387447714805603,
0.2513348460197449,
-0.2610495388507843,
0.6089475750923157,
0.14957717061042786,
-0.5707224011421204,
-0.1335962414741516,
-0.14472153782844543,
-0.5727832317352295,
-0.0022189097944647074,
-0.6323811411857605,
0.44539859890937805,
-0.25432753562927246,
0.10173208266496658,
-0.5465558767318726,
-0.5263035297393799,
-0.45218491554260254,
0.02537815272808075,
-0.44063451886177063,
-0.7982175946235657,
-0.14027729630470276,
0.47591379284858704,
0.5666311383247375,
0.22155965864658356,
-0.7896633744239807,
0.0574336051940918,
0.1521509438753128,
0.37040093541145325,
0.2505669593811035,
0.5405459403991699,
0.305769681930542,
0.341545969247818,
0.20309117436408997,
-0.10723556578159332,
0.12755411863327026,
-0.4527061879634857,
-0.5016997456550598,
0.21014980971813202,
0.07713569700717926,
0.08356110006570816,
-1.11870276927948,
-0.0748792514204979,
0.5571147203445435,
0.4906246066093445,
-0.48785391449928284,
-0.9283944964408875,
-0.19374406337738037,
-0.4341694414615631,
1.0117261409759521,
-0.8454024791717529,
0.16860631108283997,
-0.13115638494491577,
-0.6996691226959229,
0.30997714400291443,
-0.809619128704071,
3.756810188293457,
1.6649619340896606,
1.1204988956451416,
-0.12695272266864777,
1.0921679735183716,
0.2891346514225006,
0.4883638620376587,
0.3310740888118744,
-0.25084826350212097,
0.4005613327026367,
0.07181835174560547,
0.28069689869880676,
-0.14391681551933289,
0.5308185815811157,
0.5156965851783752,
0.509429395198822,
-0.9535691142082214,
0.28242531418800354,
-0.2317633032798767,
-0.576770544052124,
-0.7276740074157715,
-0.0914049819111824,
0.37118273973464966,
-0.2317769080400467,
-0.13452884554862976,
0.06298858672380447,
-0.14567144215106964,
0.048869043588638306,
-0.1263769268989563,
0.014780930243432522,
-0.45758479833602905,
-0.3192336857318878,
0.5958115458488464,
-0.9723414182662964,
-0.499815970659256,
-0.14321312308311462,
-0.21312467753887177,
-0.9673868417739868,
0.33989280462265015,
-0.2677660584449768,
0.544449508190155,
-0.11197776347398758,
-0.008217575959861279,
-0.062228359282016754,
0.10875596851110458,
-0.19625180959701538,
-0.5917550921440125,
0.16337010264396667,
0.955480694770813,
-0.1496482789516449,
0.7156669497489929,
-1.0103411674499512,
0.13569588959217072,
-0.7011550068855286,
-0.7681630849838257,
-0.33500757813453674,
0.08035334199666977,
-0.6512291431427002,
-0.32974350452423096,
0.17437899112701416,
0.723453938961029,
0.11698645353317261,
0.032510906457901,
-0.6444980502128601,
0.2642967104911804,
-0.6427546739578247,
0.34555941820144653,
0.2772693932056427,
-0.3067032992839813,
-0.5478233695030212,
-0.5268294215202332,
-0.7434354424476624,
0.2583589255809784,
-0.5168443322181702,
0.35086333751678467,
0.1319444477558136,
-0.23249174654483795,
0.524329423904419,
0.1967860609292984,
0.018924914300441742,
0.4223378300666809,
0.3497004210948944,
0.14058169722557068,
0.3627811074256897,
0.6550858616828918,
0.37274277210235596,
-0.22760732471942902,
-0.08333619683980942,
-0.24827416241168976,
0.36874377727508545,
0.9295721054077148,
-0.6609209179878235,
0.16258931159973145,
-0.0015921011799946427,
-0.48079603910446167
] | {"Title": "Machine learning pattern recognition and differential network analysis of gastric microbiome in the presence of proton pump inhibitor treatment or Helicobacter pylori infection", "Authors": "Ciucci Sara, Dur\u00e1n Claudio, Palladini Alessandra, Ijaz Umer Z., Sterbini Francesco Paroni, Masucci Luca, Cammarota Giovanni, Ianiro Gianluca, Spuul Pirjo, Schroeder Michael, Grill Stephan W., Parsons Bryony N., Pritchard D. Mark, Posteraro Brunella, Sanguinetti Maurizio, Gasbarrini Giovanni, Gasbarrini Antonio, Cannistraci Carlo Vittorio", "Abstract": "Abstract Although long thought to be a sterile and inhospitable environment, the stomach is inhabited by diverse microbial communities, co-existing in a dynamic balance. Long-term use of orally administered drugs such as Proton Pump Inhibitors (PPIs), or bacterial infection such as Helicobacter pylori , cause significant microbial alterations. Yet, studies revealing how the commensal bacteria re-organize, due to these perturbations of the gastric environment, are in the early phase. They mainly focus on the most prevalent taxa and rely on linear techniques for multivariate analysis. Here we disclose the importance of complementing linear dimensionality reduction techniques such as Principal Component Analysis and Multidimensional Scaling with nonlinear approaches derived from the physics of complex systems. Then, we show the importance to complete multivariate pattern analysis with differential network analysis, to reveal mechanisms of re-organizations which emerge from combinatorial microbial variations induced by a medical treatment (PPIs) or an infectious state ( H. pylori ).", "URL": "https://doi.org/10.1101/2020.03.24.005587"} |
10.1101/001750 | [
0.22186869382858276,
0.38148683309555054,
0.5870532989501953,
-0.3312063217163086,
0.5221579074859619,
0.6894264221191406,
-0.3934689164161682,
0.20332777500152588,
1.3008898496627808,
-0.13840028643608093,
0.2418169230222702,
-0.7771829962730408,
0.07134026288986206,
-0.6637018918991089,
0.3628789186477661,
0.1836983859539032,
-0.3203088939189911,
0.09222610294818878,
-0.6937563419342041,
0.38091370463371277,
-0.2833290696144104,
-0.6726367473602295,
-0.28456544876098633,
-0.6015884876251221,
0.4000011682510376,
-0.17044822871685028,
0.776127278804779,
-0.01353510282933712,
1.439110279083252,
0.2180008590221405,
0.5454076528549194,
-0.4260914623737335,
0.6232509016990662,
-0.2585090398788452,
-0.31761783361434937,
0.5927155613899231,
-0.24327461421489716,
-0.30140697956085205,
-0.08886847645044327,
-1.2809478044509888,
1.2373296022415161,
-0.4875079393386841,
-0.2435322403907776,
-0.3660838007926941,
-0.16194188594818115,
-0.37381550669670105,
-0.08416281640529633,
-0.7766587734222412,
-1.047195553779602,
-0.8011347055435181,
0.4789995551109314,
-0.23729471862316132,
-0.22650474309921265,
-1.3982399702072144,
-1.074397325515747,
0.1491868793964386,
0.7990492582321167,
0.08896049857139587,
-0.11695515364408493,
0.5940250158309937,
0.20493079721927643,
0.33806633949279785,
0.49875202775001526,
-0.9121119379997253,
0.1607915759086609,
0.7078642845153809,
0.018499813973903656,
0.13602884113788605,
-0.6328576803207397,
-0.5829355120658875,
-0.8456518650054932,
0.12980492413043976,
0.3318329453468323,
0.1721983253955841,
-0.8540024757385254,
0.05803932249546051,
0.17911575734615326,
-0.208842471241951,
-0.2026756852865219,
0.30569949746131897,
0.5728952884674072,
1.39919912815094,
-0.7680178284645081,
0.15945225954055786,
-0.8110666275024414,
0.20222020149230957,
0.14771556854248047,
0.5956175923347473,
-0.07694877684116364,
0.7805123925209045,
0.2385675013065338,
1.2419034242630005,
0.07110646367073059,
0.14422398805618286,
0.09210383147001266,
0.7538658380508423,
-0.349688857793808,
0.8100734949111938,
-0.344655841588974,
-0.05168265104293823,
0.7737809419631958,
0.2954854369163513,
0.08584248274564743,
0.7147262096405029,
-1.1868815422058105,
0.844803512096405,
0.6501345038414001,
0.037178151309490204,
0.3620685338973999,
-1.4589017629623413,
0.3234550356864929,
0.3726637661457062,
-0.029982570558786392,
0.32887908816337585,
0.42884764075279236,
0.20400112867355347,
-0.07102528214454651,
0.4021712839603424,
-0.9949532151222229,
0.1263461709022522,
-0.21914903819561005,
-0.11694108694791794,
-0.4696575999259949,
1.0255701541900635,
0.00947957206517458,
-0.9607120156288147,
-0.7036347389221191,
0.7155897617340088,
-0.12747254967689514,
0.18762919306755066,
-0.18023335933685303,
-0.8973115086555481,
-0.6481954455375671,
0.857891321182251,
0.15914252400398254,
0.0648621916770935,
-0.43779194355010986,
1.093575119972229,
-0.35875412821769714,
-1.716752290725708,
0.30697721242904663,
0.7194287776947021,
-0.16765019297599792,
1.9518152475357056,
0.0640401765704155,
0.13751724362373352,
-0.12753510475158691,
-0.39817342162132263,
-0.09017020463943481,
0.1374422162771225,
-0.7220574021339417,
-0.25760218501091003,
-0.5703465938568115,
0.6239826083183289,
-0.39005735516548157,
-0.3398691415786743,
-0.6573992967605591,
0.190021350979805,
0.1801765114068985,
0.33037084341049194,
-0.0774167999625206,
-0.03712733834981918,
-0.04965147376060486,
0.1454514116048813,
-0.6434080004692078,
0.6807730197906494,
-0.5599414706230164,
-0.17776261270046234,
0.09497451037168503,
-0.15037326514720917,
0.5313173532485962,
-0.16433939337730408,
0.5432253479957581,
-0.4653885066509247,
0.38449668884277344,
0.6828701496124268,
0.1785619556903839,
0.32664915919303894,
0.5094851851463318,
0.7429038286209106,
0.5253438949584961,
0.12293451279401779,
0.38231945037841797,
0.5864021182060242,
-0.6483893394470215,
-0.7231308221817017,
-0.22798843681812286,
-0.1108085960149765,
-0.06551571935415268,
-0.2572672367095947,
-0.5917459726333618,
0.5310724973678589,
-0.0086623290553689,
-0.029531026259064674,
-0.33864128589630127,
-0.016433341428637505,
0.3822201192378998,
0.5698711276054382,
0.39627575874328613,
-0.2057613879442215,
-0.5191988348960876,
0.9954994916915894,
-0.7198636531829834,
-0.37032830715179443,
-0.8201034665107727,
-0.7920693755149841,
0.4331135153770447,
0.7819446921348572,
-0.6664704084396362,
0.8217002749443054,
0.9736925959587097,
-0.6442922353744507,
-0.07840137183666229,
0.37189874053001404,
0.025447506457567215,
-0.3149227797985077,
0.250904381275177,
0.3351384401321411,
0.016503386199474335,
-0.7628995180130005,
0.7479444742202759,
-0.14025267958641052,
0.14310835301876068,
-0.2663780450820923,
0.21622705459594727,
0.701038122177124,
0.4675029516220093,
1.155866265296936,
-0.16680780053138733,
0.8510499596595764,
0.6233741641044617,
0.9961130023002625,
0.1222093477845192,
0.24064622819423676,
0.11404554545879364,
-0.15644869208335876,
0.09196886420249939,
0.3272329866886139,
0.782970130443573,
-0.13372066617012024,
1.117053747177124,
-0.1400478333234787,
0.2616390883922577,
0.2199430763721466,
0.15878261625766754,
0.7288499474525452,
-0.44036102294921875,
-0.6215882897377014,
-0.1734292060136795,
0.012517863884568214,
-0.2806858420372009,
1.0666464567184448,
-0.6025446653366089,
-0.052706047892570496,
0.1966078281402588,
0.21195028722286224,
1.2821054458618164,
-0.29087477922439575,
0.5892819166183472,
-0.2973145842552185,
0.10301250964403152,
-0.2516171336174011,
0.3238312900066376,
-0.5881015062332153,
0.22194668650627136,
0.4676385223865509,
-0.3891209661960602,
0.20198369026184082,
-0.24808883666992188,
-0.9958806037902832,
-0.40871647000312805,
-0.6665533185005188,
-1.5266910791397095,
-0.2990396022796631,
-0.5807228684425354,
-0.3080735206604004,
-0.2555882930755615,
-0.7465209364891052,
0.6362066864967346,
-0.6464971303939819,
-0.04218870773911476,
-0.6123117804527283,
-0.17970146238803864,
-0.05563734099268913,
-0.1748981475830078,
0.29270878434181213,
-0.31490862369537354,
0.9084257483482361,
-0.308184415102005,
0.4140825867652893,
-0.477508008480072,
-0.23701921105384827,
-1.053701639175415,
-0.3531102240085602,
0.3338428735733032,
0.07833071798086166,
0.26211559772491455,
-0.24043303728103638,
-0.5936015844345093,
-0.750113308429718,
-0.5186240077018738,
0.039274685084819794,
-0.614352285861969,
-0.4836152493953705,
-0.19261904060840607,
0.2780120372772217,
-0.3430860936641693,
-0.7175527811050415,
0.20554716885089874,
0.6244043111801147,
-0.6376330256462097,
0.7086285948753357,
-0.2548758387565613,
0.45986607670783997,
-0.7128447890281677,
0.854127824306488,
0.29056885838508606,
-0.586754322052002,
-0.17079761624336243,
-0.42738524079322815,
-0.2639480531215668,
-0.5762746930122375,
-0.019723132252693176,
-0.037686631083488464,
0.03610636666417122,
1.234135389328003,
-0.10919991135597229,
-0.6704723834991455,
0.5302262902259827,
-0.28322696685791016,
-0.29379111528396606,
0.08295682817697525,
-0.3619931638240814,
0.003103632712736726,
0.16754858195781708,
-0.005484576802700758,
0.41129356622695923,
-0.14444376528263092,
0.6699638366699219,
0.8900336623191833,
-0.16838905215263367,
-0.6472406983375549,
0.5682287812232971,
0.5346852540969849,
0.2882045805454254,
0.2868814170360565,
0.18291300535202026,
-0.3115628957748413,
-0.17932531237602234,
0.24722881615161896,
-0.8160800337791443,
0.4258696734905243,
-0.46727511286735535,
0.19045616686344147,
0.2200416773557663,
0.13231004774570465,
-0.37413498759269714,
-0.5741220712661743,
-0.9940366744995117,
0.015081919729709625,
-0.617987871170044,
0.14566096663475037,
0.1331108808517456,
-0.31273961067199707,
-0.4626481235027313,
0.48513463139533997,
0.3654206395149231,
0.28016334772109985,
0.05967717245221138,
-0.19509130716323853,
1.1293890476226807,
0.5695726275444031,
-0.27748873829841614,
-0.09856609255075455,
0.15239904820919037,
0.8757113218307495,
0.46999678015708923,
-0.26191163063049316,
0.09009077399969101,
-0.7511094808578491,
-0.03641184791922569,
-0.1373559534549713,
0.5062412619590759,
0.6398304104804993,
-0.05382578819990158,
0.008032812736928463,
0.08003824949264526,
0.08836986124515533,
-0.8533657193183899,
-0.4358014762401581,
-0.18387651443481445,
-0.010205280967056751,
-0.21522493660449982,
-0.7799440622329712,
-0.6906864047050476,
-0.9059227108955383,
1.012008547782898,
1.0094656944274902,
0.6746261715888977,
0.27789705991744995,
-0.10063190013170242,
-0.8664125800132751,
-0.7132580876350403,
0.7751107811927795,
-0.19784408807754517,
0.29894575476646423,
-0.71913743019104,
0.00400274945423007,
0.42368483543395996,
-0.32748112082481384,
0.23845097422599792,
-0.14898796379566193,
0.100405253469944,
0.3317083418369293,
0.4184144139289856,
0.27093660831451416,
-0.5763391256332397,
0.08168536424636841,
0.1984555423259735,
0.7333544492721558,
-0.1631072461605072,
-0.18178564310073853,
-0.27880439162254333,
1.0274590253829956,
0.597855269908905,
-0.5920157432556152,
-0.26207128167152405,
-0.7513412237167358,
-0.02404404617846012,
0.36539483070373535,
-0.06175905093550682,
-0.020358525216579437,
0.1376160979270935,
0.5814015865325928,
-1.0676586627960205,
0.30126646161079407,
1.1678338050842285,
0.15860240161418915,
0.16059698164463043,
-0.3192533552646637,
0.17536021769046783,
0.310819536447525,
-0.6317425966262817,
-0.4964594542980194,
0.2824034094810486,
0.0793667733669281,
-0.12988077104091644,
0.7186216115951538,
-0.6494669914245605,
-0.21590390801429749,
0.2604873776435852,
-0.6916817426681519,
0.48400360345840454,
-0.6700538396835327,
-0.42500630021095276,
-0.5987605452537537,
0.7660932540893555,
-0.8943847417831421,
0.008325237780809402,
-0.17369185388088226,
-0.34662914276123047,
0.16685238480567932,
0.39094221591949463,
-0.6847544312477112,
0.0645279809832573,
0.5989025235176086,
-0.2731923758983612,
0.2684869170188904,
1.2044740915298462,
0.49067243933677673,
-0.06867466121912003,
-0.2886312007904053,
-0.286134272813797,
-0.6985766291618347,
0.2373843640089035,
-0.7478854656219482,
0.11519671976566315,
-0.05799179524183273,
-0.24857598543167114,
0.23029033839702606,
-0.7996669411659241,
0.5677082538604736,
-0.34264320135116577,
-0.1630418747663498,
-0.862021803855896,
-0.04954375699162483,
-0.40553608536720276,
0.3089016079902649,
-0.1179652139544487,
0.09320239722728729,
-0.9387414455413818,
-0.30122828483581543,
0.7097598314285278,
-0.43892398476600647,
-0.32634568214416504,
-0.3817647695541382,
-0.32047775387763977,
-0.5322749614715576,
-0.0919422060251236,
0.0038306370843201876,
0.7230618000030518,
0.5511147975921631,
0.7838250398635864,
-0.07699151337146759,
0.24027349054813385,
-0.422780305147171,
-0.5580671429634094,
-0.6235290765762329,
-0.41061505675315857,
0.7522562742233276,
-0.7990626096725464,
-0.34106817841529846,
-0.14860035479068756,
0.669840395450592,
-0.30599483847618103,
0.3927749991416931,
1.0982704162597656,
0.2951633036136627,
-0.2382252812385559,
0.4117244780063629,
-0.19998301565647125,
-0.339914470911026,
0.028194833546876907,
0.8433389663696289,
0.867929220199585,
0.6435045599937439,
-0.13211438059806824,
-0.724502444267273,
-0.42376652359962463,
-0.7408586740493774,
-0.060513172298669815,
-0.6921680569648743,
-0.2726331055164337,
-0.7465041279792786,
0.28322651982307434,
-0.11561883985996246,
-0.2206559032201767,
0.3013308644294739,
-0.21822817623615265,
-0.6037732362747192,
-1.0022324323654175,
-0.061860814690589905,
-0.3280637264251709,
-0.722507119178772,
0.12590745091438293,
0.04071030020713806,
0.056401561945676804,
1.509071946144104,
0.4738723635673523,
-0.5178807377815247,
0.07873464375734329,
0.07254928350448608,
0.9652438163757324,
0.6416128873825073,
-0.9281764626502991,
-0.11811164021492004,
-0.3640059530735016,
0.47937726974487305,
0.06991949677467346,
-0.023899121209979057,
0.33405426144599915,
0.040081534534692764,
-0.6918069124221802,
-0.06745267659425735,
0.7682251930236816,
0.7561635971069336,
-0.3621692359447479,
0.316985547542572,
0.6893396377563477,
-0.05589153245091438,
0.3979390561580658,
-0.22551319003105164,
0.5628149509429932,
0.7572889924049377,
-0.07004961371421814,
-0.4878026247024536,
0.10867241024971008,
-0.7440187931060791,
-0.870479166507721,
0.5918713808059692,
0.08586437255144119,
-0.5257863998413086,
0.17823079228401184,
-0.302913099527359,
1.1786624193191528,
-0.7400498390197754,
0.3352085053920746,
0.9915679693222046,
0.4568137228488922,
-0.025533683598041534,
0.36820465326309204,
-0.3963768184185028,
0.957739531993866,
-0.25249984860420227,
0.022580333054065704,
0.2214069664478302,
0.03378693386912346,
0.23916596174240112,
-0.4155702292919159,
-0.7879070043563843,
-0.6977139115333557,
0.7854329347610474,
0.1158982589840889,
0.811431348323822,
0.921205461025238,
0.2108602672815323,
-0.49609848856925964,
-0.24604560434818268,
0.5286127328872681,
0.4826892018318176,
0.0567953884601593,
0.9008587598800659,
0.046711649745702744,
-0.01672356203198433,
0.1568034142255783,
0.45138540863990784,
-0.09600802510976791,
-0.7758511900901794,
1.6216318607330322,
0.07406861335039139,
-0.9802548885345459,
-0.6782901287078857,
-0.004057182930409908,
-0.5994647741317749,
-0.7827385067939758,
-0.5495885014533997,
-0.018489331007003784,
0.7150377631187439,
-0.24163304269313812,
0.13160911202430725,
0.23286758363246918,
-0.9698721170425415,
0.027949579060077667,
0.3887125551700592,
-0.8248007893562317,
-0.1942177712917328,
0.19733119010925293,
-0.20453974604606628,
-0.7361782193183899,
0.6841237545013428,
1.3088175058364868,
-0.14327387511730194,
-0.19755494594573975,
-0.11720702052116394,
0.12973889708518982,
-0.3803323805332184,
-0.3087630569934845,
0.6467402577400208,
-0.3397369682788849,
1.1496553421020508,
-0.2353440374135971,
0.44862741231918335,
-0.29758888483047485,
-0.12947559356689453,
0.2746772766113281,
0.4675312340259552,
-0.8290214538574219,
-0.4390328526496887,
-0.7927584648132324,
0.8574342727661133,
-0.08073028922080994,
0.7397399544715881,
-0.14639809727668762,
-0.22601181268692017,
0.5498352646827698,
-0.10330304503440857,
-1.1016926765441895,
-0.5185471773147583,
-0.3125779330730438,
-0.9866592884063721,
-0.2786984443664551,
0.036602262407541275,
-0.5265305042266846,
0.3316664397716522,
0.6767396926879883,
-0.5631403923034668,
-0.20817653834819794,
0.25915756821632385,
0.4677243232727051,
-0.2271653413772583,
0.7887470722198486,
-0.1576397866010666,
0.514436662197113,
-0.7565233111381531,
-0.09947637468576431,
-0.12715351581573486,
-0.4782153367996216,
-0.4351814091205597,
0.21019385755062103,
-0.3562529683113098,
0.3679487407207489,
-0.3644668459892273,
1.3100558519363403,
0.42872777581214905,
0.10786260664463043,
-0.46149811148643494,
-0.7460201978683472,
-1.2415388822555542,
-0.11953335255384445,
-0.06819995492696762,
0.42793604731559753,
0.6174277663230896,
-0.3623678982257843,
0.48269158601760864,
0.35560327768325806,
-0.5408769249916077,
0.11711541563272476,
0.37725594639778137,
0.9726378321647644,
-0.8565208315849304,
-0.4482877254486084,
0.07701820135116577,
0.33225196599960327,
-0.514909029006958,
-0.08221783488988876,
0.010509553365409374,
0.595416247844696,
-0.15556132793426514,
-0.735421895980835,
0.3733333945274353,
0.9969592094421387,
0.2049376368522644,
0.38002240657806396,
-1.291325330734253,
-0.5441945195198059,
0.6649190187454224,
-0.3277963697910309,
-0.4742801785469055,
0.03387100622057915,
0.17369729280471802,
-1.2848292589187622,
0.635955810546875,
0.4954718053340912,
-0.1864582896232605,
0.8029260635375977,
0.26936012506484985,
0.6442638039588928,
0.576178252696991,
0.14731256663799286,
-0.7636933922767639,
0.5846279859542847,
-0.8231640458106995,
0.7105982303619385,
0.5021548271179199,
-0.6854233741760254,
-0.8447360396385193,
0.6575501561164856,
-1.4334125518798828,
0.1577834039926529,
-0.10736954212188721,
-0.494595468044281,
0.002081606537103653,
-0.424222469329834,
-0.05854853615164757,
-0.5387898683547974,
0.23985368013381958,
0.14391489326953888,
0.7244970202445984,
0.6134196519851685,
-0.4607466161251068,
0.28303423523902893,
-0.006283814087510109,
-0.5446239709854126,
0.2450011819601059,
-0.648620069026947,
-0.8278792500495911,
-1.1303972005844116,
-0.17885495722293854,
-0.530165433883667,
-0.6677550077438354,
-0.314822256565094,
-0.5751556754112244,
0.31921467185020447,
-0.6616734862327576,
-0.04310932755470276,
-0.7964223623275757,
0.9226258397102356,
0.06309542059898376,
0.2291104644536972,
0.19867995381355286,
-0.29087892174720764,
-0.34542983770370483,
-0.14685790240764618,
0.8801537156105042,
-0.4844147562980652,
-0.5605466961860657,
-0.0715443417429924,
0.7495449185371399,
-0.35979336500167847,
0.24895578622817993,
0.06550687551498413,
0.40106621384620667,
-0.2861802577972412,
0.2985873520374298,
0.33985406160354614,
0.05649866163730621,
0.006346277426928282,
0.00038577563827857375,
0.6572248935699463,
0.2535528242588043,
-0.06555601209402084,
-0.4142431616783142,
0.007643711753189564,
0.7365164160728455,
0.2057441920042038,
-0.3664083182811737,
-0.1331821084022522,
-0.34633299708366394,
0.3347736597061157,
0.15281671285629272,
-0.2236657291650772,
0.057995304465293884,
0.34163227677345276,
-0.5106712579727173,
0.2839454412460327,
0.096215158700943,
1.359145164489746,
-0.3518371880054474,
-1.118586778640747,
-0.6038006544113159,
-0.18658649921417236,
1.139803409576416,
-0.1221262663602829,
0.6724669933319092,
0.06780872493982315,
0.9301462769508362,
0.3441953957080841,
-0.6476557850837708,
0.4250185191631317,
0.5998014211654663,
-0.7135102152824402,
-0.46623659133911133,
0.2870852053165436,
0.9426562786102295,
0.02351958677172661,
-0.4128566384315491,
-1.0504101514816284,
-1.1051243543624878,
0.7508928179740906,
-0.40871793031692505,
-0.557136595249176,
0.3330618441104889,
-0.4733935296535492,
-0.39544016122817993,
0.045885372906923294,
-0.3013116717338562,
-0.20438125729560852,
0.18178316950798035,
0.09617453068494797,
-0.7305459976196289,
-0.4497193396091461,
0.9080102443695068,
0.37954697012901306,
0.9569809436798096,
-0.39334654808044434,
0.6118282079696655,
-0.8236371278762817,
0.6609596610069275,
0.6886166930198669,
0.2946160137653351,
0.4949423372745514,
-0.06925332546234131,
-0.13371407985687256,
-0.4042302668094635,
-0.41627705097198486,
-0.774928092956543,
0.4081430733203888,
0.31698673963546753,
-0.5593569278717041,
-0.056665219366550446,
0.7442642450332642,
-0.6852294206619263,
0.11552915722131729,
-0.03789915889501572,
0.3879850208759308,
-0.7476861476898193,
0.1805405169725418,
0.3486621677875519,
0.3514803647994995,
0.5445969700813293,
-0.15909194946289062,
0.38424190878868103,
-0.6560708284378052,
-0.00183163583278656,
0.06259020417928696,
0.6626582741737366,
0.1693507879972458,
-1.0793792009353638,
-0.1610250174999237,
-0.7464332580566406,
-0.5845237970352173,
-0.38023120164871216,
-0.07603126764297485,
-0.8091591000556946,
0.9854204654693604,
0.7695615887641907,
0.12413300573825836,
0.6641725301742554,
-0.3502860963344574,
-0.0953289046883583,
0.15546774864196777,
0.780249297618866,
0.272977352142334,
0.353441059589386,
0.4811685085296631,
-0.2496539205312729,
-0.7828527688980103,
-1.1001932621002197,
-0.29732826352119446,
0.45785459876060486,
-0.2633025646209717,
0.21561016142368317,
0.33258703351020813,
-1.0105199813842773,
-0.7729882597923279,
0.7995279431343079,
1.0434906482696533,
0.3715709447860718,
0.1879855841398239,
-0.8819591999053955,
0.5521058440208435,
-0.5992190837860107,
0.19015930593013763,
-1.0983539819717407,
-0.44209688901901245,
1.0268794298171997,
-0.6660311222076416,
0.5036094784736633,
-0.5652280449867249,
3.8322699069976807,
0.6217172741889954,
-0.11551599204540253,
-0.10459129512310028,
0.14534582197666168,
0.5458908081054688,
0.6541410684585571,
-0.20450890064239502,
0.027326347306370735,
0.1876363903284073,
-0.27814164757728577,
0.6741098165512085,
0.5407259464263916,
-0.024818867444992065,
0.1697402149438858,
0.4320369064807892,
-0.6530694961547852,
0.02317841164767742,
0.1113712415099144,
-0.711614727973938,
-0.2841496169567108,
0.1514105349779129,
0.1445043832063675,
0.18646790087223053,
0.8847963809967041,
0.5977319478988647,
-0.02668105438351631,
-0.8140305876731873,
0.19294773042201996,
-0.1858016550540924,
-0.046497687697410583,
-0.24082514643669128,
-0.03723762929439545,
0.2175445556640625,
-0.5322589874267578,
0.09073546528816223,
0.41574761271476746,
-0.1573898047208786,
-0.5679590106010437,
0.2974686920642853,
0.07877358049154282,
-0.7613440155982971,
-0.4565238058567047,
-0.7235594987869263,
-0.7658517360687256,
-0.054747097194194794,
-0.3633810579776764,
0.32282817363739014,
0.5419443845748901,
-0.37224844098091125,
0.27081793546676636,
-0.4820418655872345,
-0.04717365652322769,
-0.07144711911678314,
-0.737188994884491,
0.1680075228214264,
0.13516227900981903,
-0.30842792987823486,
-0.1285196989774704,
0.2143867313861847,
0.22531257569789886,
-0.6116366386413574,
-0.6428927779197693,
0.2530258595943451,
-0.045176949352025986,
0.8351442813873291,
-0.22077132761478424,
0.18969540297985077,
-0.7196555733680725,
-1.1916340589523315,
-0.009889558888971806,
-1.1891967058181763,
-0.6380614042282104,
-0.26482880115509033,
1.4816454648971558,
0.8707697987556458,
-0.06969360262155533,
0.6725181937217712,
-0.09635436534881592,
-1.1562362909317017,
-0.07484232634305954,
-0.07861337810754776,
0.4713950753211975,
-0.6148686408996582,
1.337819218635559,
-0.03754618391394615,
-0.25865858793258667,
-0.7308319807052612,
-0.6414390802383423,
0.5004665851593018,
0.88116854429245,
1.2223098278045654,
-0.08201069384813309,
0.32129648327827454,
-0.6849919557571411
] | {"Title": "Shifts in stability and control effectiveness during evolution of paraves support aerial maneuvering hypotheses for flight origins", "Authors": "Evangelista Dennis, Cam Sharlene, Huynh Tony, Kwong Austin, Mehrabani Homayun, Tse Kyle, Dudley Robert", "Abstract": "Abstract The capacity for aerial maneuvering was likely a major influence on the evolution of flying animals. Here we evaluate consequences of paravian morphology for aerial performance by quantifying static stability and control effectiveness of physical models for numerous taxa sampled from within the lineage leading to birds (Paraves). Results of aerodynamic testing are mapped phylogenetically to examine how maneuvering characteristics correspond to tail shortening, forewing elaboration, and other morphological features. In the evolution of Paraves we observe shifts from static stability to inherently unstable aerial planforms; control effectiveness also migrated from tails to the forewings. These shifts suggest that some degree of aerodynamic control and and capacity for maneuvering preceded the evolution of strong power stroke. The timing of shifts also suggests features normally considered in light of development of a power stroke may play important roles in control.", "URL": "https://doi.org/10.1101/001750"} |
10.1101/003483 | [
0.14607521891593933,
0.0663909912109375,
0.707687258720398,
-0.11623673141002655,
0.06357263028621674,
0.2253827303647995,
0.4069175124168396,
-0.5409094095230103,
0.30648165941238403,
1.0247328281402588,
0.6231518983840942,
-0.9331751465797424,
0.6345575451850891,
-0.3569197654724121,
-0.2926209568977356,
-0.12315533310174942,
0.6990174651145935,
-0.5676583647727966,
-0.34141629934310913,
-0.08704397827386856,
-0.35072025656700134,
-0.28097739815711975,
-0.5287951231002808,
0.2534821033477783,
-0.13217775523662567,
1.0330538749694824,
-0.8795748949050903,
0.31274503469467163,
1.6126552820205688,
-0.26883235573768616,
-0.06768092513084412,
-0.9181901812553406,
-0.4720039665699005,
-0.7293896675109863,
0.039733368903398514,
0.07006578892469406,
-0.35993534326553345,
0.8844731450080872,
0.04903624951839447,
-0.3077947497367859,
-0.02825522981584072,
0.4612138569355011,
1.257759690284729,
-0.5655053853988647,
-0.5340296626091003,
-0.7022037506103516,
-1.0988212823867798,
-0.28248488903045654,
-0.04079717770218849,
-0.43376514315605164,
-0.31521326303482056,
0.3374535143375397,
-0.485363245010376,
0.14591999351978302,
0.21575964987277985,
0.22675691545009613,
0.47700145840644836,
-0.029439963400363922,
-0.9155401587486267,
0.6300375461578369,
0.3510586619377136,
-0.9009371995925903,
0.2642121911048889,
-1.091941475868225,
0.7007994055747986,
0.7489339709281921,
-0.3614577353000641,
-0.9391428232192993,
0.6374909281730652,
0.1020824983716011,
-0.26233983039855957,
-0.16551539301872253,
-0.31371158361434937,
0.43666115403175354,
-0.2863786518573761,
-0.26953867077827454,
-0.2662977874279022,
-0.06035991385579109,
-1.1465317010879517,
-0.6952233910560608,
-0.4217485189437866,
0.28036507964134216,
-0.2467205822467804,
-0.015643451362848282,
-0.6042138338088989,
-1.3699208498001099,
-0.17132121324539185,
0.977104902267456,
0.1000811979174614,
0.4586487114429474,
0.40961936116218567,
0.961117148399353,
-0.09026110917329788,
0.40558922290802,
-0.6068718433380127,
1.5735615491867065,
-0.6199604272842407,
0.5443400144577026,
0.5786499977111816,
-0.9483640193939209,
0.3593163788318634,
0.9466047286987305,
-0.8709287047386169,
0.8737117648124695,
0.07561782747507095,
0.06174429878592491,
0.5231208205223083,
-0.7862330675125122,
-0.8617523908615112,
-0.7570197582244873,
0.22130142152309418,
0.08192621916532516,
-0.33850592374801636,
0.5855461359024048,
-0.344865083694458,
0.390661358833313,
-0.017874915152788162,
0.8428724408149719,
0.1320437341928482,
0.166063129901886,
0.26110413670539856,
-0.4413308799266815,
0.22587621212005615,
0.028783002868294716,
-0.3449094593524933,
0.4103216528892517,
0.039755627512931824,
0.5679680705070496,
-0.4632905423641205,
0.25196635723114014,
-0.49288660287857056,
-0.8084847331047058,
-0.4943203330039978,
0.7975051999092102,
-0.39476409554481506,
-0.03156186640262604,
-0.12432786822319031,
0.25389957427978516,
-0.6241009831428528,
-1.1681395769119263,
1.0045742988586426,
0.01623782329261303,
-0.2834893763065338,
1.2007232904434204,
0.504352331161499,
0.35104817152023315,
-0.5599130988121033,
-0.4998260736465454,
-0.05039573460817337,
0.17125540971755981,
-0.7095398902893066,
0.46167558431625366,
0.016689524054527283,
-0.2066986858844757,
-0.3470461964607239,
0.148692786693573,
0.11702518910169601,
0.024797486141324043,
-0.2984171509742737,
-0.046893466264009476,
0.40306222438812256,
0.2530279755592346,
0.21807995438575745,
0.02897331491112709,
-0.9068708419799805,
1.037089467048645,
0.08074703067541122,
-0.23354877531528473,
-0.5067384243011475,
-0.4277321398258209,
0.8024979829788208,
0.029505819082260132,
-0.5202831029891968,
0.6092149019241333,
-0.017162326723337173,
-0.058766815811395645,
0.8045830130577087,
0.22923754155635834,
0.061746783554553986,
0.5826565623283386,
-0.2039467990398407,
-0.25468552112579346,
0.2248644381761551,
0.07667100429534912,
-0.4901115298271179,
0.8078092336654663,
0.29588252305984497,
-0.4553346633911133,
-0.7040606141090393,
0.1097826361656189,
-0.0796826183795929,
0.7256105542182922,
0.3722860515117645,
0.3735581040382385,
-0.16118834912776947,
0.25887706875801086,
-1.2933470010757446,
0.06794492900371552,
0.13370901346206665,
-0.7294421195983887,
-1.0526299476623535,
0.6027786135673523,
0.06163942068815231,
-0.4887040853500366,
-1.042231798171997,
0.4996930658817291,
0.17691656947135925,
1.066402792930603,
-0.8682296872138977,
0.5726840496063232,
-0.052083276212215424,
-0.5508109331130981,
-0.14549075067043304,
0.36588039994239807,
0.23176808655261993,
-1.138182520866394,
0.4639173746109009,
0.059823039919137955,
0.6013038158416748,
0.610319197177887,
-0.1391913890838623,
-0.5773352384567261,
0.8847907185554504,
0.05764710158109665,
-0.3964959383010864,
0.6338875889778137,
0.8961946368217468,
0.22036290168762207,
0.246739000082016,
-0.1625596284866333,
0.14773087203502655,
0.6083901524543762,
-0.2960206866264343,
0.8975657820701599,
0.4242333471775055,
-0.12407979369163513,
-0.3485698997974396,
0.4499706029891968,
0.15584403276443481,
0.7585033178329468,
0.5565518140792847,
-0.558662474155426,
0.5609638690948486,
1.068071722984314,
0.018516406416893005,
0.10756704211235046,
-0.4477525055408478,
0.1408592015504837,
-0.6245610117912292,
0.15408368408679962,
0.08016900718212128,
0.7975066304206848,
0.8306311964988708,
0.39651963114738464,
-0.18604642152786255,
-0.35298851132392883,
0.03757588192820549,
0.3636086583137512,
-0.36362817883491516,
-0.4390580654144287,
0.003938792739063501,
0.28041714429855347,
-0.20848308503627777,
-0.14565037190914154,
0.9326565861701965,
0.5224064588546753,
-0.7741701602935791,
0.3186047077178955,
-0.6328444480895996,
-0.00972706824541092,
-0.49631714820861816,
-0.8304846286773682,
-0.429943710565567,
0.08759171515703201,
-1.2128937244415283,
-0.7237427234649658,
0.4154180884361267,
-0.7189627885818481,
0.9368875622749329,
0.031161673367023468,
-0.3821469843387604,
-0.032947320491075516,
-0.35285672545433044,
0.9935505390167236,
0.47748541831970215,
0.44594278931617737,
-0.7766894698143005,
0.6428003907203674,
-0.47426941990852356,
0.29506900906562805,
-0.7880078554153442,
0.25212401151657104,
-0.48392218351364136,
-0.49924081563949585,
0.37771880626678467,
-0.5854763388633728,
-0.11923173069953918,
-0.26648446917533875,
-0.03936551883816719,
-0.005871606059372425,
-0.5662826895713806,
0.3573607802391052,
-0.3188399374485016,
-0.2382548302412033,
-1.1200165748596191,
0.6175248026847839,
0.29479357600212097,
0.3238469064235687,
0.0727500393986702,
0.9308459758758545,
-0.9300914406776428,
0.868168294429779,
0.1579878032207489,
0.015733134001493454,
-0.52237868309021,
0.5605263113975525,
1.119559645652771,
0.6610584855079651,
0.3499683737754822,
-0.44568485021591187,
-0.7726390361785889,
0.07348202168941498,
0.4285445213317871,
-0.46237245202064514,
-0.48524269461631775,
0.757007360458374,
0.8830954432487488,
-1.0880192518234253,
0.08518154919147491,
-0.3926727771759033,
-0.8561170697212219,
0.2727813720703125,
0.7970339059829712,
-0.011747938580811024,
-0.1825161874294281,
0.36989423632621765,
0.06684685498476028,
-0.1451970934867859,
-0.05481050908565521,
-0.12564848363399506,
0.1259443312883377,
-0.9160128831863403,
0.6480778455734253,
0.40502020716667175,
0.4233221709728241,
0.17255736887454987,
1.043973684310913,
-0.18383285403251648,
-0.46326982975006104,
-0.4378061890602112,
-0.20988330245018005,
0.29261040687561035,
0.6692525744438171,
-0.06658920645713806,
-0.1458914428949356,
0.28267359733581543,
-0.11389530450105667,
-0.460649311542511,
-0.5898612141609192,
-0.3607371747493744,
0.732276439666748,
1.0360760688781738,
-0.3302835524082184,
-0.397951602935791,
-0.6424456238746643,
-0.6509783864021301,
1.0024781227111816,
0.0035342914052307606,
0.5944064259529114,
-0.678550660610199,
0.3154265582561493,
0.4624057114124298,
-0.7984791994094849,
0.6851000189781189,
0.01230610441416502,
-0.16704456508159637,
0.7198498249053955,
-0.235836461186409,
1.2018572092056274,
-0.14270181953907013,
-0.10462558269500732,
0.4508025050163269,
0.9820338487625122,
0.9537262320518494,
0.5708344578742981,
1.0314295291900635,
-0.22903582453727722,
-0.4557919204235077,
-0.5157363414764404,
0.2072611302137375,
0.665372371673584,
-0.5538604855537415,
-0.5727255940437317,
0.5695508718490601,
-0.4876657724380493,
0.29105496406555176,
0.6752685904502869,
1.333419919013977,
-0.2157471776008606,
0.26892974972724915,
0.22716407477855682,
-0.2875986397266388,
0.7182274460792542,
0.2654859721660614,
0.6674262285232544,
0.27148327231407166,
-0.6975910067558289,
-0.15583200752735138,
0.4559820294380188,
0.45077160000801086,
-0.4646742641925812,
-0.44032156467437744,
-0.17196564376354218,
0.13427847623825073,
-0.14585652947425842,
0.7824510335922241,
-0.6430253386497498,
-0.13345180451869965,
-0.3266509473323822,
0.9973764419555664,
-0.29413849115371704,
0.31247615814208984,
-0.778658926486969,
-0.16088992357254028,
0.4658205211162567,
-0.6467111110687256,
-0.5539547801017761,
-0.29443636536598206,
-0.05461196228861809,
0.37423956394195557,
-0.821087658405304,
-0.3801531493663788,
-0.31433185935020447,
0.02755776233971119,
-0.9674286246299744,
0.8203915357589722,
0.005926772486418486,
-0.4183490574359894,
0.27060750126838684,
0.16010403633117676,
-0.2567625343799591,
-0.6424323916435242,
-0.5732348561286926,
-0.27286002039909363,
-0.6820263266563416,
-0.12892848253250122,
-0.015574174001812935,
0.46659284830093384,
0.48834657669067383,
0.2351505309343338,
0.717018187046051,
-0.35594791173934937,
0.7174773812294006,
-0.4668663442134857,
0.2233482450246811,
-0.235820010304451,
-0.4114212393760681,
-0.10877744108438492,
0.2678632438182831,
0.12848608195781708,
-0.08193003386259079,
-0.3493763208389282,
-0.5316139459609985,
0.33070656657218933,
-1.1011983156204224,
0.6172728538513184,
-0.10308001935482025,
0.6157097816467285,
0.9928606152534485,
0.6396899819374084,
-0.12269789725542068,
0.0659424439072609,
0.11688107252120972,
-1.2887974977493286,
0.6865037679672241,
0.1794246882200241,
0.7421808838844299,
0.12172558903694153,
-0.09585323929786682,
0.10435207933187485,
-0.3011186420917511,
0.42744097113609314,
-0.5803233981132507,
-0.5105730891227722,
-0.6552706360816956,
-0.31558912992477417,
-0.8739398717880249,
0.5912446975708008,
-0.3106759488582611,
0.3607514202594757,
0.02430596575140953,
-0.3422408401966095,
0.895918607711792,
-0.3365224003791809,
0.2776336073875427,
-0.6621975898742676,
-0.9013440012931824,
0.08493253588676453,
0.21646684408187866,
0.21992313861846924,
1.1701072454452515,
0.3671131134033203,
-1.229001760482788,
0.30480435490608215,
-0.1547713279724121,
0.3420506417751312,
-0.30853238701820374,
-0.19522243738174438,
-0.28084704279899597,
-0.5850765109062195,
-0.49399200081825256,
-0.7669374942779541,
0.10248429328203201,
-0.3542934060096741,
0.02116035297513008,
-0.014545595273375511,
0.5399863123893738,
-0.4976904094219208,
-0.5152197480201721,
-0.23959366977214813,
0.5508284568786621,
-0.5227419137954712,
-1.0648014545440674,
0.5147712230682373,
-0.5633318424224854,
0.3934001326560974,
-0.6849506497383118,
-0.8612260818481445,
-0.12555022537708282,
-0.5349771976470947,
-0.18564046919345856,
-0.5109345316886902,
0.03945959731936455,
-0.5313804745674133,
-0.44598180055618286,
0.06749528646469116,
0.3327600359916687,
0.533641517162323,
0.11412642896175385,
-0.6914247274398804,
-1.0690616369247437,
-0.17419952154159546,
-0.4500108063220978,
-0.09094815701246262,
-0.38457000255584717,
-1.1642992496490479,
0.01043691672384739,
1.2900723218917847,
0.5813722610473633,
-0.7225465774536133,
0.6385273933410645,
0.09856847673654556,
0.7430638670921326,
0.48096799850463867,
-0.35537171363830566,
0.23260438442230225,
0.4228305220603943,
0.7914959192276001,
-0.31897011399269104,
0.25121161341667175,
-0.7519543766975403,
-0.11303413659334183,
-1.4103078842163086,
0.38779255747795105,
-0.07102752476930618,
-0.37229248881340027,
0.4029872417449951,
-0.30232253670692444,
0.6891546249389648,
-0.6140869855880737,
-0.1395946890115738,
-0.3506375849246979,
-0.19425012171268463,
-0.279812216758728,
0.0183789674192667,
-0.019416773691773415,
-0.14622743427753448,
-0.636081874370575,
-0.9688615202903748,
0.31197357177734375,
-0.8579639792442322,
-0.6599965691566467,
0.7250530123710632,
0.3364717662334442,
0.38201621174812317,
-1.3106768131256104,
0.639390230178833,
0.3944395184516907,
-0.4115655720233917,
-0.8445069193840027,
1.0452208518981934,
0.09129752963781357,
-0.3193484842777252,
-0.49508407711982727,
0.5110966563224792,
0.057736836373806,
-0.26616916060447693,
0.11278396844863892,
-0.12189973890781403,
-1.0901672840118408,
-0.05820562317967415,
0.4537145495414734,
0.4408237338066101,
-0.22269460558891296,
0.458312064409256,
-0.5642976760864258,
-0.11388400942087173,
-0.11497289687395096,
0.5750672221183777,
-0.5490046143531799,
0.43733665347099304,
0.9669017791748047,
-0.2589453160762787,
0.9161978363990784,
0.697117805480957,
0.07153930515050888,
-1.0316921472549438,
0.11938915401697159,
1.1792911291122437,
0.32458066940307617,
-1.0993918180465698,
0.33423590660095215,
0.23756666481494904,
-0.8025110960006714,
-0.33949875831604004,
0.10772842168807983,
-0.12526194751262665,
0.38654616475105286,
-0.5425001382827759,
-0.34221893548965454,
0.3504579961299896,
-0.4610908329486847,
0.46493932604789734,
-0.017342427745461464,
-0.2594347894191742,
0.0261093582957983,
-0.27955907583236694,
-0.6304608583450317,
-0.13665586709976196,
1.0282697677612305,
0.9919053316116333,
0.13195504248142242,
-0.04281216859817505,
-0.32008716464042664,
0.7176109552383423,
-0.7259733080863953,
-0.49815085530281067,
0.22861571609973907,
0.6431240439414978,
0.06715423613786697,
-0.09138879179954529,
0.6131268739700317,
-0.12722355127334595,
-0.3437083959579468,
0.059803761541843414,
0.4095592796802521,
0.5865333080291748,
-0.7074770927429199,
0.09070239961147308,
1.0299501419067383,
0.8831045031547546,
0.43980100750923157,
0.055010657757520676,
-0.579768717288971,
0.8276352286338806,
-0.3635440170764923,
-0.5541967749595642,
-0.511907696723938,
-0.01128985732793808,
-0.860995888710022,
0.15972599387168884,
0.39249101281166077,
-0.22579161822795868,
0.32914119958877563,
0.5315445065498352,
-0.1357889175415039,
-0.5801505446434021,
-1.0570673942565918,
-0.23214125633239746,
0.12820671498775482,
-0.08673399686813354,
-0.3419695794582367,
-0.11112423241138458,
-0.9450016617774963,
-0.5200369954109192,
-0.7881780862808228,
-0.10928553342819214,
-0.27617546916007996,
0.7395794987678528,
-0.0408063605427742,
-0.17118249833583832,
-0.28092271089553833,
0.6623818874359131,
-0.26361653208732605,
-0.2262418568134308,
-0.3481385111808777,
-0.06848083436489105,
-0.8021597266197205,
0.4035899043083191,
-0.041514500975608826,
0.7914248704910278,
0.7528367638587952,
-0.040549565106630325,
-0.4511021375656128,
0.8559346795082092,
-0.8186864256858826,
-0.9581825733184814,
-1.0153579711914062,
-0.09345365315675735,
-0.6159157752990723,
-0.5243796110153198,
-0.04924963787198067,
0.7443926334381104,
-1.3001694679260254,
-0.8424919247627258,
-0.2944472134113312,
0.39597466588020325,
-0.026130452752113342,
-0.049471527338027954,
0.30331701040267944,
0.8948705196380615,
0.08003172278404236,
0.27537259459495544,
-0.8034734129905701,
-0.021567286923527718,
0.3898254632949829,
0.06346490234136581,
-0.02250056341290474,
0.2233150154352188,
0.04858649522066116,
0.11932159215211868,
0.1577710062265396,
0.24878239631652832,
-0.43542060256004333,
-0.22888720035552979,
0.1910952776670456,
1.047711730003357,
-0.1245986595749855,
0.6172181963920593,
-0.1634313315153122,
0.8369262218475342,
0.028516829013824463,
-0.6641765832901001,
-0.2750163972377777,
-0.981890857219696,
-0.25538507103919983,
-0.4912194013595581,
-1.0928417444229126,
-1.0058989524841309,
0.9648858308792114,
-0.2756957411766052,
0.07591404020786285,
-0.5374022722244263,
-0.6078232526779175,
0.2454802691936493,
0.7944449186325073,
0.8425594568252563,
-0.3402210772037506,
0.39346373081207275,
0.02602159045636654,
-0.021071147173643112,
0.21926890313625336,
0.09516733139753342,
-0.036055855453014374,
-0.2358616143465042,
-0.2818727195262909,
-0.847169816493988,
-0.0491161122918129,
0.025901464745402336,
0.0698467344045639,
-0.3119134306907654,
-0.3617987632751465,
-0.043579451739788055,
0.4669138193130493,
-0.05139971897006035,
-0.7198792099952698,
1.1494723558425903,
-0.9758954644203186,
-0.20171435177326202,
-1.07048499584198,
-0.3823252022266388,
-0.004336872138082981,
0.542891800403595,
0.24645362794399261,
-0.2207770198583603,
-0.5552597641944885,
-0.1959008425474167,
0.6276177763938904,
-0.505394458770752,
1.5997387170791626,
-0.032866399735212326,
0.78511643409729,
-1.0943342447280884,
0.012984391301870346,
0.7075463533401489,
0.16441623866558075,
0.40570542216300964,
-0.15704241394996643,
-0.36449775099754333,
0.3725000321865082,
0.7122804522514343,
0.3245418667793274,
-0.586843729019165,
0.8423117995262146,
0.2298404425382614,
-0.4147771894931793,
0.2964489161968231,
0.00482976483181119,
0.11167002469301224,
-0.17813386023044586,
-0.08869551122188568,
0.19389525055885315,
0.39226070046424866,
-0.5008936524391174,
-0.6500195264816284,
-0.168184295296669,
0.8814085125923157,
-0.08768933266401291,
-1.1936068534851074,
0.03730609640479088,
0.6452618837356567,
1.143843650817871,
0.613075315952301,
-0.9249356985092163,
0.006370306946337223,
0.7748587131500244,
0.3109191358089447,
-0.28799882531166077,
0.6982337832450867,
-0.7324068546295166,
0.32418155670166016,
-0.3957124352455139,
0.47245168685913086,
0.4665719270706177,
0.6199935078620911,
0.17740198969841003,
-0.8025590777397156,
0.14343591034412384,
0.502852201461792,
-0.5224932432174683,
-0.05019877105951309,
0.08381470292806625,
0.028754161670804024,
-0.06805364042520523,
-0.7959775924682617,
0.4105164706707001,
-0.5978593826293945,
0.29799357056617737,
0.9657188057899475,
-0.86918705701828,
0.332881361246109,
0.31706520915031433,
0.24238060414791107,
0.7665283679962158,
-0.4961072504520416,
0.5509727597236633,
-0.4227076470851898,
1.1986111402511597,
0.6443808078765869,
0.8418415784835815,
0.1851748675107956,
-0.01716799847781658,
0.4049682021141052,
-0.5861526727676392,
0.1507260650396347,
-0.03889497369527817,
0.19372624158859253,
-0.15125618875026703,
-0.10779298841953278,
0.508353590965271,
0.3364660143852234,
-0.7221347093582153,
-0.3592013716697693,
-0.18098331987857819,
0.6146482229232788,
0.200566828250885,
-0.21884702146053314,
0.7735359072685242,
-0.20839335024356842,
-0.466400146484375,
0.6576968431472778,
-0.3876399099826813,
-0.07515612244606018,
-0.15563252568244934,
-0.6310948133468628,
0.29548802971839905,
0.4898611009120941,
0.21968193352222443,
-0.21502098441123962,
-0.7540767192840576,
-0.20359912514686584,
-0.15337680280208588,
-0.19113968312740326,
-1.0714064836502075,
0.6201371550559998,
0.2791597843170166,
0.7153273224830627,
-0.475663423538208,
-0.8448092937469482,
0.2450518012046814,
-0.4055604636669159,
1.2418969869613647,
-0.09206830710172653,
0.7035307884216309,
0.747318685054779,
0.42144253849983215,
-0.24188818037509918,
0.41183900833129883,
0.09741128981113434,
-0.44955554604530334,
0.38579946756362915,
-0.4725426137447357,
-0.5008294582366943,
-0.28178125619888306,
-0.4246615469455719,
0.15606829524040222,
0.45677322149276733,
-0.5722013711929321,
-0.17987503111362457,
-0.2918618321418762,
0.5322806239128113,
0.1721111387014389,
0.17124561965465546,
-0.5649212002754211,
0.08633670955896378,
0.3072946071624756,
-0.09255950897932053,
0.060432709753513336,
-1.1200484037399292,
3.841460943222046,
1.7566503286361694,
0.8613073825836182,
0.040544040501117706,
0.2614043354988098,
-0.24195082485675812,
0.45681291818618774,
-0.6766121983528137,
-0.1737021803855896,
-0.470447301864624,
0.2829194664955139,
-0.23050551116466522,
0.43249234557151794,
-0.09541451930999756,
0.15628810226917267,
0.4858987331390381,
-1.6411798000335693,
-0.20355352759361267,
-0.4655419588088989,
-0.9801886081695557,
-0.45445752143859863,
0.23440976440906525,
-0.09910138696432114,
-1.0304760932922363,
-0.19945891201496124,
0.1970061957836151,
-0.5805438756942749,
-0.021963590756058693,
-0.275114506483078,
0.27640169858932495,
0.15108609199523926,
-0.9127659201622009,
0.5646979212760925,
0.6190784573554993,
-0.7013665437698364,
-0.15630634129047394,
-0.1115766167640686,
-0.20832855999469757,
-0.5965588688850403,
0.46437886357307434,
0.01001726370304823,
-0.5737205743789673,
-0.4925675094127655,
0.5543149709701538,
-0.5376887917518616,
-0.4008764922618866,
-0.0973249152302742,
0.04164855554699898,
0.25448089838027954,
-0.38266515731811523,
1.2064735889434814,
-0.3946588337421417,
0.5073995590209961,
-0.15543325245380402,
-0.7396881580352783,
0.258637011051178,
0.10035295784473419,
-0.28474509716033936,
-0.08933010697364807,
1.2193523645401,
0.27371838688850403,
0.20284831523895264,
-0.49782392382621765,
-1.131148099899292,
0.2353644073009491,
0.8511878252029419,
-0.10587082803249359,
0.5858639478683472,
-0.05509456992149353,
-0.6636509299278259,
0.2826318144798279,
-0.566053569316864,
0.37991803884506226,
0.7611983418464661,
0.48558539152145386,
0.2729254364967346,
-0.6625548005104065,
0.30467191338539124,
-0.13307368755340576,
-0.5983395576477051,
0.952044665813446,
0.3243942856788635,
-0.05170191824436188,
-0.08932355791330338,
-0.02638092450797558,
0.6182346343994141,
-0.17607811093330383,
0.30262550711631775,
-0.05386386066675186,
0.0589144192636013,
0.53969806432724,
0.3122985064983368,
0.20520249009132385,
-0.11136523634195328,
0.16538526117801666
] | {"Title": "Identification of five patterns of nucleosome positioning that globally describe transcription factor function", "Authors": "Maehara Kazumitsu, Ohkawa Yasuyuki", "Abstract": "ABSTRACT Following the binding of transcription factors (TF) to specific regions, chromatin remodeling including alterations in nucleosome positioning (NP) occurs. These changes in NP cause selective gene expression to determine cell function. However whether specific NP patterns upon TF binding determine the transcriptional regulation such as gene activation or suppression is unclear. Here we identified five patterns of NP around TF binding sites (TFBSs) using fixed MNase-Seq analysis. The most frequently observed NP pattern described the transcription state. The five patterns explained approximately 80% of the whole NP pattern on the genome in mouse C2C12 cells. We further performed ChIP-Seq using the input obtained from the fixed MNase-Seq. The result showed that a single trial of ChIP-Seq could visualize the NP patterns around the TFBS and predict the function of the transcriptional regulation at the same time. These findings indicate that NP can directly predict the function of TFs.", "URL": "https://doi.org/10.1101/003483"} |
10.1101/2020.03.25.007732 | [
-0.13656949996948242,
-0.14318707585334778,
0.9528563618659973,
0.5931279063224792,
-0.09458506107330322,
0.535705029964447,
-0.527128279209137,
-0.2999855577945709,
0.5981650352478027,
1.3067550659179688,
0.27551043033599854,
-0.38445809483528137,
1.1412816047668457,
0.02781188115477562,
-1.1453255414962769,
0.40926575660705566,
0.7929991483688354,
-0.4105159342288971,
0.27759334444999695,
-0.5262194871902466,
-0.6757831573486328,
0.25571972131729126,
-0.695894181728363,
-0.10150988399982452,
-0.871317982673645,
0.3126421272754669,
0.1608911156654358,
0.08661045134067535,
1.0399878025054932,
0.18959073722362518,
0.5739654898643494,
-0.2614927887916565,
0.629421055316925,
-0.7605804800987244,
-0.21473106741905212,
-0.7050910592079163,
0.5274019241333008,
-0.4597246050834656,
0.15821920335292816,
-0.30434465408325195,
1.4779349565505981,
0.3867785632610321,
0.9086302518844604,
0.15047627687454224,
-0.04523907229304314,
-0.15792222321033478,
-0.06097523495554924,
0.9283257126808167,
-0.7542820572853088,
-0.7852458953857422,
0.17246413230895996,
0.6179475784301758,
-0.3667146563529968,
-0.28706786036491394,
-0.2414708286523819,
-0.22060059010982513,
0.01990518905222416,
-0.7130250930786133,
-0.5277711153030396,
0.6723055243492126,
0.10665971040725708,
-0.17384500801563263,
0.32705819606781006,
-0.598225474357605,
0.04533220827579498,
1.221103310585022,
-0.6622424721717834,
0.42286571860313416,
0.024471567943692207,
-0.10128593444824219,
-0.23683376610279083,
0.15107941627502441,
-0.21591711044311523,
-0.6583305597305298,
-0.7783092856407166,
0.055376581847667694,
0.16942276060581207,
-0.15348897874355316,
-0.050472501665353775,
0.40517184138298035,
-0.8461684584617615,
0.4847790002822876,
-0.1903519183397293,
0.23580853641033173,
-0.7769976854324341,
-0.12438459694385529,
-1.0044689178466797,
0.5185030102729797,
-0.188994899392128,
0.6515303254127502,
0.4410279393196106,
0.9907658696174622,
0.7405346632003784,
-0.49235790967941284,
-0.5652986168861389,
0.5249896049499512,
-1.2495429515838623,
0.34674951434135437,
0.9004591703414917,
0.06820882856845856,
0.20218117535114288,
0.5182936787605286,
-0.30328646302223206,
0.7477630376815796,
-0.44875410199165344,
0.6706915497779846,
0.8489806056022644,
0.5988463759422302,
-0.5701272487640381,
-1.0137194395065308,
0.2437833994626999,
0.3341433107852936,
-1.2569661140441895,
-0.5891818404197693,
0.43675604462623596,
0.05574951693415642,
-0.057517509907484055,
0.7126865386962891,
-0.6667283177375793,
0.15103638172149658,
0.6729167103767395,
-0.4627080261707306,
0.686905026435852,
-0.07373543083667755,
0.20526263117790222,
0.017155280336737633,
-0.05257350951433182,
0.7564823627471924,
-0.34523358941078186,
0.055108219385147095,
0.3348289132118225,
-0.31717002391815186,
0.15454532206058502,
0.2925046384334564,
-0.03530405834317207,
0.7485691905021667,
0.01708575338125229,
0.5025604367256165,
0.9306460022926331,
-0.05624355748295784,
0.13220828771591187,
0.06552919745445251,
-0.4944566786289215,
1.3972759246826172,
-0.2935442328453064,
0.6337049603462219,
-0.16136537492275238,
-1.0698729753494263,
0.04205526039004326,
0.5692466497421265,
-0.6880413889884949,
0.2551175057888031,
-0.8483184576034546,
0.16267162561416626,
-0.25528019666671753,
0.5093633532524109,
-0.4040904939174652,
0.27759963274002075,
-0.7440263032913208,
-0.2997378706932068,
-0.20234093070030212,
-0.08795274794101715,
0.2908368408679962,
0.6173871159553528,
-0.44144850969314575,
-0.11761562526226044,
-0.5335517525672913,
-0.09124096482992172,
-0.1325090378522873,
-0.6766546964645386,
0.7235234975814819,
0.049420636147260666,
-0.608285129070282,
0.7856917977333069,
0.6513195633888245,
0.6289951801300049,
0.7077556848526001,
-0.6350489854812622,
-0.3806942403316498,
0.15261784195899963,
0.5561541318893433,
-0.30415424704551697,
0.40001821517944336,
0.890949547290802,
-0.08397011458873749,
0.22077243030071259,
-0.14369171857833862,
0.28872448205947876,
-0.22179651260375977,
-0.5451257824897766,
0.2915087640285492,
0.7111462950706482,
-1.0742311477661133,
0.3668287396430969,
-0.09765776991844177,
-0.09820401668548584,
-0.6933498382568359,
0.20177610218524933,
-0.4318210184574127,
-0.5522471070289612,
-0.0026068168226629496,
-0.4159983992576599,
-0.6481403708457947,
-0.13289251923561096,
-0.8829436302185059,
0.45729461312294006,
-0.18225574493408203,
0.5240989327430725,
-0.7724034190177917,
-0.22330306470394135,
0.6837862133979797,
-0.7630209922790527,
-0.04033519700169563,
-0.5501295924186707,
-0.18103976547718048,
-0.6387771964073181,
0.3132988512516022,
0.04934502765536308,
0.5909815430641174,
0.3370414972305298,
0.255083829164505,
-0.6424712538719177,
0.020557114854454994,
0.931992769241333,
-0.11317542940378189,
0.2424192577600479,
-0.44904905557632446,
-0.1982138752937317,
-0.10967729240655899,
-0.08814892172813416,
0.03842739388346672,
0.3763599693775177,
-0.13541144132614136,
1.0484681129455566,
0.8425845503807068,
0.9316878318786621,
0.41579335927963257,
-0.06523578613996506,
0.6632503271102905,
-0.017054608091711998,
0.4509173035621643,
0.12611573934555054,
0.13515721261501312,
0.14060844480991364,
0.38481655716896057,
-0.23224373161792755,
-0.5539548397064209,
0.5586768984794617,
-1.0672857761383057,
0.49132150411605835,
-0.7253665924072266,
0.4858703017234802,
0.4248846769332886,
0.4059846103191376,
-0.32452619075775146,
0.06558717042207718,
0.680164635181427,
0.1119014322757721,
-1.0096973180770874,
0.05247315391898155,
0.02211078815162182,
0.39832475781440735,
-0.8802667856216431,
0.06150934100151062,
0.770380437374115,
0.8955182433128357,
0.3486127555370331,
0.6287175416946411,
-0.08955096453428268,
0.056200020015239716,
-0.7698236703872681,
-0.2351432591676712,
-0.6202505826950073,
0.023147866129875183,
-0.5973251461982727,
-0.576629638671875,
0.0783008560538292,
-0.11753644794225693,
0.47581785917282104,
0.00148565205745399,
0.34381482005119324,
-0.16033488512039185,
0.1338956207036972,
0.4755646288394928,
0.12010980397462845,
-0.47627124190330505,
-0.8607354164123535,
0.3845183253288269,
-0.38477423787117004,
-0.050360389053821564,
-0.49130308628082275,
0.21380101144313812,
-0.3053188621997833,
-0.5463432669639587,
-0.37862369418144226,
0.2930663228034973,
0.6595376133918762,
0.37292346358299255,
0.07963231950998306,
-0.08755624294281006,
0.2740738093852997,
0.4184313118457794,
0.5855944752693176,
-0.9858832359313965,
-0.9110795259475708,
0.7753827571868896,
0.49933305382728577,
-0.01365160383284092,
-0.018886465579271317,
-0.024692565202713013,
-0.8294199109077454,
0.2294427454471588,
0.05003514140844345,
0.06531376391649246,
-0.7419066429138184,
0.47082415223121643,
0.9599092602729797,
0.7759724259376526,
0.25911441445350647,
-1.29612398147583,
-0.5075644850730896,
0.044194020330905914,
0.44172605872154236,
-0.8546016812324524,
-0.7476816773414612,
0.7971544861793518,
0.3912200629711151,
-0.7446828484535217,
0.7604900598526001,
0.6099221706390381,
0.028602033853530884,
0.1358015090227127,
0.10237710177898407,
0.6233330368995667,
0.307406485080719,
0.28607022762298584,
0.0723775252699852,
0.162344828248024,
-0.384706974029541,
-0.02040896750986576,
-0.066535584628582,
0.05026392638683319,
0.3266806900501251,
0.40348905324935913,
-0.25529682636260986,
0.15703459084033966,
0.7402409315109253,
-0.7111636996269226,
0.21852360665798187,
-0.1366087943315506,
-0.42343422770500183,
-0.3720173239707947,
0.349410742521286,
0.30071237683296204,
0.48769423365592957,
0.6454776525497437,
-0.27452391386032104,
-0.1490790843963623,
-0.5721539258956909,
-0.21289785206317902,
-0.16775624454021454,
1.0175918340682983,
-0.6106460094451904,
0.15850912034511566,
-0.8425964713096619,
-0.9423512816429138,
0.2364710420370102,
0.43382546305656433,
0.18684455752372742,
-0.46010762453079224,
0.4482354521751404,
0.07746235281229019,
-0.17820776998996735,
0.21449097990989685,
-0.003045473014935851,
0.02201888896524906,
0.5762673616409302,
1.0338011980056763,
0.6528342366218567,
-0.41334807872772217,
-0.029869303107261658,
-0.28706270456314087,
0.1998092085123062,
0.2989540100097656,
0.15271426737308502,
0.3292212188243866,
-1.1851669549942017,
-0.16682018339633942,
-0.22034814953804016,
-0.2816547751426697,
-0.005512727424502373,
-0.5678398609161377,
0.7909035682678223,
-0.782582700252533,
0.16267035901546478,
-0.5067512392997742,
0.393893837928772,
0.25222086906433105,
-0.6382233500480652,
0.8301828503608704,
0.33161166310310364,
-0.08484890311956406,
0.039729729294776917,
0.5819678902626038,
0.048354435712099075,
-0.1073114350438118,
-0.7672886252403259,
0.5190032720565796,
-0.4767097532749176,
0.12551024556159973,
-0.5701698064804077,
-0.20813584327697754,
-0.12863655388355255,
-0.06105857715010643,
-0.0838019996881485,
0.24076376855373383,
-0.23228080570697784,
0.37282148003578186,
-0.5077012777328491,
-0.024815287441015244,
-0.30981114506721497,
-0.7278645038604736,
-0.3742136061191559,
0.5734044313430786,
0.27023443579673767,
-0.3702835738658905,
0.21802444756031036,
-0.4562951624393463,
0.5562845468521118,
-0.01203057449311018,
-0.25790807604789734,
-0.6040212512016296,
-0.6045953035354614,
-0.04298154264688492,
-1.1410305500030518,
0.5373299717903137,
0.5961818695068359,
-0.34610480070114136,
0.45567768812179565,
-0.1380273997783661,
-0.13200843334197998,
-0.26392900943756104,
0.10317139327526093,
-0.30715450644493103,
0.32316285371780396,
0.4694087505340576,
1.2750701904296875,
0.5074445009231567,
0.24680815637111664,
-0.05575065314769745,
0.08034519851207733,
-0.48047617077827454,
0.3574898838996887,
-0.5810176730155945,
-0.07565832138061523,
0.43194231390953064,
-0.4930395781993866,
0.21789933741092682,
0.9184532165527344,
0.2591831088066101,
-0.0576237216591835,
-0.1701033115386963,
0.03011758252978325,
-0.692075252532959,
0.15176261961460114,
0.6554860472679138,
-0.1151999905705452,
0.07177737355232239,
0.5903136134147644,
0.24199169874191284,
-0.07074626535177231,
0.2830088436603546,
0.44987568259239197,
-0.6064214706420898,
0.5208356380462646,
0.023320835083723068,
-0.06866438686847687,
0.553413450717926,
0.21572422981262207,
-0.36722037196159363,
-0.42792510986328125,
-0.1701987385749817,
0.11243782937526703,
0.03086203895509243,
0.7647546529769897,
-0.015995793044567108,
0.12510989606380463,
-0.23880703747272491,
-0.44199037551879883,
-0.27795907855033875,
0.2902495861053467,
0.0739898532629013,
0.8618305325508118,
-0.2560161054134369,
0.07110430300235748,
-0.4201323986053467,
0.11358318477869034,
-0.5119918584823608,
0.17049254477024078,
-0.3479010760784149,
0.5069190859794617,
0.43063053488731384,
-1.1531472206115723,
1.1007423400878906,
-0.4045953154563904,
-0.4144122004508972,
-0.6067864298820496,
0.4697200357913971,
-0.7538243532180786,
-0.0956324115395546,
-0.5215786099433899,
0.36489933729171753,
-0.4180307388305664,
-0.5737462639808655,
0.1711626648902893,
0.5428049564361572,
0.674245297908783,
0.5871081352233887,
-0.41453781723976135,
0.23772376775741577,
0.07561139762401581,
0.14829754829406738,
-0.46164679527282715,
1.1578891277313232,
-0.5274512767791748,
0.2078768014907837,
0.18299594521522522,
-0.6639878153800964,
-0.20930342376232147,
-0.3618038296699524,
0.22886471450328827,
-0.9606497883796692,
0.00931660644710064,
-0.3786143958568573,
-0.45352786779403687,
-0.3403043746948242,
0.4136315882205963,
-0.007036988157778978,
-0.27392351627349854,
0.13880079984664917,
-0.9728627800941467,
0.20998482406139374,
-0.0685679018497467,
0.29311445355415344,
-0.5374735593795776,
-0.3966340124607086,
-0.8335249423980713,
0.4572402536869049,
-0.6648463606834412,
-0.5863794088363647,
-0.16898506879806519,
0.14254730939865112,
1.2618844509124756,
0.099230095744133,
-0.049703389406204224,
-0.42139071226119995,
0.027131695300340652,
0.7310382723808289,
-0.7563756704330444,
0.544368326663971,
-0.6216892600059509,
0.10164915770292282,
-0.6959983706474304,
-0.0626635029911995,
-0.3184055685997009,
-0.17859946191310883,
0.46900731325149536,
-0.42357972264289856,
1.2114896774291992,
-0.0033400917891412973,
0.19771313667297363,
-0.2767893671989441,
0.4400770366191864,
0.35723695158958435,
0.3483256697654724,
-0.6664686799049377,
0.37273499369621277,
-1.0894086360931396,
-0.6059868931770325,
0.8648969531059265,
0.11504964530467987,
-0.4466986060142517,
-0.4577336609363556,
-0.18005196750164032,
-0.43409228324890137,
-0.8750713467597961,
0.49710142612457275,
0.4447695016860962,
-1.2203799486160278,
-0.830985426902771,
0.04968348890542984,
0.0633380115032196,
-0.8495906591415405,
-0.8139208555221558,
-0.022799324244260788,
-0.2924603223800659,
0.14843235909938812,
-0.4772970974445343,
-0.9514322876930237,
-0.5585802793502808,
-0.10149209201335907,
0.08440367132425308,
0.227691650390625,
0.07366085052490234,
0.7396525144577026,
-0.010634463280439377,
-0.5136021971702576,
-0.1308136135339737,
-0.04001262038946152,
-0.23629625141620636,
0.4755874276161194,
0.09792459011077881,
0.3932877779006958,
-0.2614128291606903,
-0.4467219412326813,
-0.44625788927078247,
-0.4201541841030121,
-0.30663391947746277,
1.123137354850769,
-0.23771843314170837,
-0.24646955728530884,
0.5770009756088257,
0.22231966257095337,
-0.5917020440101624,
-1.0161858797073364,
-0.1615949124097824,
-0.147024467587471,
-0.16885524988174438,
0.09246135503053665,
0.12089990824460983,
-0.18854843080043793,
-0.8485449552536011,
0.4737964868545532,
0.06173904240131378,
0.2525370121002197,
0.3216145932674408,
-0.7189011573791504,
0.44058316946029663,
-0.10949185490608215,
-0.5438976287841797,
0.7843062281608582,
-0.2187851220369339,
-0.6285449862480164,
-0.5636447668075562,
-0.736489474773407,
0.3716682493686676,
-0.18820253014564514,
-0.026375889778137207,
-0.15465712547302246,
-0.44157272577285767,
0.06617279350757599,
0.3313829004764557,
0.636002779006958,
0.5138774514198303,
-0.5023297071456909,
0.25312939286231995,
0.6106996536254883,
-0.587463915348053,
-0.22846944630146027,
0.3819723129272461,
0.8035641312599182,
-0.00968092679977417,
-0.10390801727771759,
0.1095302402973175,
0.4310002624988556,
-0.3947092592716217,
0.4563917815685272,
-0.5874953866004944,
-0.8603255748748779,
-1.260389804840088,
-0.49577757716178894,
-1.127200961112976,
-0.6163753271102905,
0.5620249509811401,
0.31346407532691956,
-0.5132032036781311,
0.1853799968957901,
-0.7293139100074768,
0.29929375648498535,
-0.10652872174978256,
0.4555130898952484,
-0.624271810054779,
0.573904812335968,
-0.8450942635536194,
-0.8185981512069702,
-0.11923817545175552,
-0.7538853287696838,
-0.1012343242764473,
0.18645766377449036,
-1.0260058641433716,
-0.23779825866222382,
-0.20066425204277039,
0.634329617023468,
-0.7774434089660645,
0.37692371010780334,
-0.4686089754104614,
-0.6776756644248962,
-0.5331160426139832,
-0.03249586746096611,
0.32103145122528076,
0.6949572563171387,
0.5281297564506531,
-0.2956477105617523,
0.4615401327610016,
-0.17194801568984985,
-0.5418214797973633,
-0.49465078115463257,
-0.6694328784942627,
0.622413158416748,
-0.8272693157196045,
-0.05621148273348808,
-0.2566016614437103,
0.28958600759506226,
-1.3167203664779663,
-0.07798600941896439,
-0.5517510175704956,
0.17650988698005676,
0.5523894429206848,
0.06359510868787766,
0.09706083685159683,
0.794021487236023,
-0.5555106401443481,
0.3363361060619354,
0.03779132664203644,
0.43207669258117676,
1.118357539176941,
0.609890878200531,
0.7693714499473572,
-0.08544323593378067,
0.48775678873062134,
-1.1454523801803589,
0.1299317628145218,
0.20147204399108887,
0.04611542075872421,
0.6928666830062866,
-0.2416629195213318,
0.2428591251373291,
-0.3129151463508606,
-0.7355529069900513,
-0.9280975461006165,
-0.06705008447170258,
0.18070679903030396,
-0.26023346185684204,
-0.1596764177083969,
0.04517897590994835,
-0.5245984196662903,
-1.0559369325637817,
-0.596104085445404,
-0.4620060920715332,
0.27225932478904724,
-0.7839937806129456,
-0.9374025464057922,
-0.2538008987903595,
-0.4299297630786896,
0.229649618268013,
0.3007093667984009,
-0.22582171857357025,
-0.8030191659927368,
1.0681003332138062,
0.013460231013596058,
0.31297755241394043,
-0.3059086203575134,
0.39019402861595154,
-0.1603105068206787,
0.1612078994512558,
-0.4351961314678192,
-0.8961262702941895,
-0.09790267050266266,
0.005911054089665413,
-0.1987021565437317,
-0.35487741231918335,
-0.0038360191974788904,
0.5160742402076721,
0.48910579085350037,
-0.043036844581365585,
-0.8038395643234253,
0.10143351554870605,
-0.9094712138175964,
0.5594131946563721,
0.57972252368927,
-0.47918662428855896,
0.03782283887267113,
-0.15614260733127594,
-0.15614444017410278,
-0.03046618588268757,
-0.6341947913169861,
0.379848450422287,
0.321972131729126,
-0.10109815746545792,
0.9814077615737915,
0.38444918394088745,
0.848949134349823,
-0.17495769262313843,
-0.2525652050971985,
0.3904232978820801,
0.36409735679626465,
0.22783485054969788,
0.2061428427696228,
0.07432706654071808,
0.4732801914215088,
0.48330458998680115,
-0.2759236991405487,
-0.3514091670513153,
-0.1466521918773651,
0.34051835536956787,
-0.889916181564331,
0.369998037815094,
-0.2536546289920807,
0.21020810306072235,
0.4218740463256836,
-0.12071865797042847,
-0.5762313008308411,
0.15334784984588623,
0.12761950492858887,
0.42987290024757385,
-0.2631751000881195,
0.1131931021809578,
-0.18366451561450958,
-0.6060647964477539,
-0.15244244039058685,
-0.6568063497543335,
1.5034829378128052,
0.019110731780529022,
-0.12614727020263672,
0.14314128458499908,
1.1688843965530396,
0.1902475357055664,
-0.24486002326011658,
0.36997196078300476,
-1.155064582824707,
-0.3348015248775482,
-0.4347303807735443,
0.5606128573417664,
0.23962803184986115,
0.03932081535458565,
0.2629559636116028,
-0.7693044543266296,
-0.27175840735435486,
0.9178175330162048,
-1.0951069593429565,
-0.41467395424842834,
0.2973781228065491,
0.06259280443191528,
-0.3846288025379181,
-0.6463198065757751,
0.3305473327636719,
-0.766173779964447,
-0.24653851985931396,
0.8402043581008911,
-0.5139871835708618,
-0.042339544743299484,
-0.2071509212255478,
0.45016083121299744,
0.2661718726158142,
0.3150008022785187,
0.17643825709819794,
-0.37833529710769653,
1.2007189989089966,
0.303333044052124,
-0.3798059821128845,
0.1547781229019165,
0.2875711917877197,
-0.7600498795509338,
-0.20846736431121826,
-0.6444920897483826,
-0.43941769003868103,
0.8476018905639648,
0.0790548026561737,
-0.9479079246520996,
0.886756181716919,
-0.10086095333099365,
-0.10102494806051254,
-0.3110945224761963,
0.2813977897167206,
0.5989238023757935,
0.0352906808257103,
-0.31388694047927856,
0.41175878047943115,
0.6158910989761353,
0.49035409092903137,
-0.06643921881914139,
-0.08501309156417847,
0.14666153490543365,
-0.020046470686793327,
-0.5421426296234131,
-0.1792202889919281,
-0.3079107403755188,
0.204239159822464,
-0.10032196342945099,
-0.810584306716919,
-0.1110309362411499,
-0.3265836834907532,
-0.2076265960931778,
-0.551437497138977,
0.2267925888299942,
0.5643647909164429,
0.9972015023231506,
0.16050946712493896,
-0.40380367636680603,
0.11791042238473892,
0.5833916068077087,
0.9362624883651733,
-0.05252208933234215,
0.5509974360466003,
-0.6203563213348389,
0.14028996229171753,
0.38852056860923767,
0.17789939045906067,
0.7421453595161438,
-0.3290751278400421,
0.18721802532672882,
-0.518932580947876,
0.2981581389904022,
-1.3002840280532837,
-0.11782039701938629,
0.5639519095420837,
0.8599594831466675,
-0.45804277062416077,
-0.7056138515472412,
-0.15027998387813568,
-0.27187439799308777,
-0.6024934649467468,
0.9766536355018616,
-0.5296506881713867,
-0.1345825493335724,
0.18927504122257233,
0.1410340815782547,
-0.09438536316156387,
-0.7887212634086609,
4.125452041625977,
1.9057483673095703,
-0.12214496731758118,
-0.13379494845867157,
0.40191856026649475,
0.053745999932289124,
0.6237977743148804,
-0.8405993580818176,
0.4026374816894531,
-0.23691023886203766,
0.3625917136669159,
0.6310611367225647,
-0.05626678466796875,
0.35128656029701233,
0.27094766497612,
0.8236087560653687,
-0.6541695594787598,
0.716244101524353,
-0.11076468974351883,
-1.3942954540252686,
-0.258116215467453,
0.3867531418800354,
-0.3481556177139282,
-0.241647869348526,
0.31767311692237854,
0.3392464816570282,
0.3268977105617523,
0.6091084480285645,
-0.2794083058834076,
-0.057741690427064896,
-0.19747503101825714,
-0.1093830093741417,
0.9030585289001465,
-0.3366890847682953,
-0.7611767649650574,
0.475583553314209,
0.45575225353240967,
-0.023640388622879982,
0.346531480550766,
0.5286031365394592,
0.4007376432418823,
-0.1471874713897705,
-0.3526066243648529,
0.047179561108350754,
-0.5630865693092346,
0.6283011436462402,
-0.5568713545799255,
0.3633343279361725,
0.1714971661567688,
-0.440917044878006,
0.6399433612823486,
-0.4935699701309204,
0.135606050491333,
-0.6220336556434631,
-0.6616247892379761,
-0.3344111442565918,
0.448032021522522,
-0.10854841768741608,
0.13746413588523865,
-0.05242930352687836,
0.9249823689460754,
-0.0671953484416008,
-0.15190844237804413,
-0.4039635956287384,
0.2851901054382324,
0.18599861860275269,
0.06660833954811096,
0.861566424369812,
-0.15655145049095154,
-0.5838296413421631,
-0.18700917065143585,
-0.7452501058578491,
0.04507903382182121,
-0.2932680547237396,
0.9374781847000122,
0.5533248782157898,
-0.3010430335998535,
0.5749393701553345,
0.18460160493850708,
0.5911155939102173,
-0.10208157449960709,
-0.257216215133667,
-0.21782352030277252,
0.5151655077934265,
0.1353878527879715,
0.5709347724914551,
-0.4253709316253662,
-0.3329143822193146,
0.4068056643009186,
0.7494823932647705,
0.8296735882759094,
0.16497161984443665,
-0.5441323518753052,
-0.39786234498023987,
-0.5665562152862549
] | {"Title": "Insights into the Polyhexamethylene Biguanide (PHMB) Mechanism of Action on Bacterial Membrane and DNA: A Molecular Dynamics Study", "Authors": "Sowlati-Hashjin Shahin, Carbone Paola, Karttunen Mikko", "Abstract": "Abstract Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death. In this study we show by the means of atomistic molecular dynamics (MD) simulations that while the PHMB molecules attach to the surface of the phospholipid bilayer and partially penetrate it, they do not cause any pore formation at least within the microsecond simulation times. The polymers initially adsorb onto the membrane surface via the favourable electrostatic interactions between the phospholipid headgroups and the biguanide groups, and then partially penetrate the membrane slightly disrupting its structure. This, however, does not lead to the formation of any pores. The microsecond-scale simulations reveal that it is unlikely for PHMB to spontaneously pass through the phospholipid membrane. Our findings suggest that PHMB translocation across the bilayer may take place through binding to the phospholipids. Once inside the cell, the polymer can effectively \u2018bind\u2019 to DNA through extensive interactions with DNA phosphate backbone, which can potentially block the DNA replication process or activate DNA repair pathways. TOC Graphic", "URL": "https://doi.org/10.1101/2020.03.25.007732"} |
10.1101/003491 | [
-0.05483751744031906,
0.9400129318237305,
0.45816922187805176,
0.14039045572280884,
-0.3631080090999603,
-0.1237192302942276,
-0.21919818222522736,
-0.08223720639944077,
0.46926021575927734,
0.7601069211959839,
-0.19569817185401917,
-0.8642833828926086,
-0.10348973423242569,
-0.18031379580497742,
0.11489570140838623,
-1.2195219993591309,
-0.16532573103904724,
0.1357031613588333,
-0.9165664911270142,
0.10599906742572784,
0.2016807198524475,
0.1219584196805954,
-0.31119248270988464,
-0.20514723658561707,
0.0825510174036026,
0.7740887403488159,
-0.19003769755363464,
0.060476839542388916,
1.6876026391983032,
0.1689540594816208,
-0.10205379873514175,
-0.284004807472229,
-0.15635187923908234,
-1.5329641103744507,
-0.5187819600105286,
-0.09996867179870605,
0.529212236404419,
0.37056660652160645,
0.12324350327253342,
-0.13671456277370453,
0.37080127000808716,
-0.0009813847718760371,
0.19043253362178802,
-0.16782835125923157,
-0.647526741027832,
0.022143274545669556,
-0.6524584889411926,
-0.2655612528324127,
-0.38508111238479614,
0.4656902253627777,
-0.5540628433227539,
-0.06703385710716248,
-0.35158571600914,
-0.4648788571357727,
-0.12249324470758438,
0.37777236104011536,
0.9942362904548645,
0.17051023244857788,
-0.5635818839073181,
0.6228913068771362,
0.7307959198951721,
0.16815349459648132,
0.9638871550559998,
-1.2318719625473022,
0.8208941221237183,
0.7143280506134033,
0.28065523505210876,
-0.20452283322811127,
-0.048044025897979736,
-0.7016391754150391,
-0.5140023827552795,
-0.3542186915874481,
0.08251597732305527,
-0.482383668422699,
-0.5192961692810059,
-0.05155958980321884,
0.40604662895202637,
-0.2305968999862671,
-0.11792159825563431,
0.5596007704734802,
0.7866501212120056,
-0.024153009057044983,
0.03692885488271713,
-0.8212441802024841,
-0.6538295745849609,
-0.8890990614891052,
0.17069528996944427,
0.7220315337181091,
-0.30659860372543335,
0.8338558673858643,
-0.32541465759277344,
1.0762418508529663,
0.2645309567451477,
0.30217012763023376,
-0.5071341395378113,
1.1963376998901367,
-0.3825720548629761,
-0.09919585287570953,
0.03092644177377224,
-0.5637736916542053,
0.8696627020835876,
0.18853141367435455,
-0.5602036118507385,
0.9010778069496155,
-0.4445204436779022,
0.13642872869968414,
-0.21657516062259674,
0.6476423740386963,
-1.2459232807159424,
-0.8536335825920105,
0.6017701029777527,
0.0571935772895813,
-0.6076653599739075,
0.3206775486469269,
0.06977542489767075,
1.1563310623168945,
-0.3480207324028015,
0.20057889819145203,
-1.1164840459823608,
-0.6120312809944153,
-0.1456761509180069,
0.21513614058494568,
0.24987152218818665,
0.33845826983451843,
-0.21082279086112976,
-0.5148907899856567,
-0.6036666035652161,
0.6373593807220459,
-0.4504900872707367,
0.03970696032047272,
-0.2770909070968628,
-0.08207236975431442,
-0.05873905494809151,
0.8113297820091248,
-0.041567493230104446,
0.2641791105270386,
0.0038997915107756853,
0.5430755615234375,
-0.16950084269046783,
-1.5945905447006226,
0.5930718183517456,
0.6094796657562256,
-0.7874842882156372,
1.4862127304077148,
-0.06166484206914902,
0.04011766240000725,
-0.4848741292953491,
-1.2294604778289795,
-0.2698369324207306,
0.4542626142501831,
-0.14360423386096954,
0.33625108003616333,
-0.8558793067932129,
-0.5525599122047424,
-0.316241979598999,
0.24678350985050201,
-0.4582518935203552,
0.1491367220878601,
0.07995220273733139,
0.012628119438886642,
-0.16177460551261902,
0.3528344929218292,
0.17878150939941406,
0.2876099944114685,
-0.9660851955413818,
0.5119819045066833,
-0.05474994704127312,
0.008336341008543968,
-0.04643239453434944,
0.07048061490058899,
0.20638878643512726,
-0.34475961327552795,
0.05039647966623306,
1.0247455835342407,
0.14258728921413422,
0.21956053376197815,
1.4292958974838257,
-0.8525717258453369,
-0.15266939997673035,
0.31411832571029663,
-0.008624818176031113,
0.5118396878242493,
-0.30165719985961914,
-0.09096561372280121,
-0.04306457191705704,
0.3590473532676697,
-0.017773248255252838,
-0.560250461101532,
-1.0206427574157715,
0.514197051525116,
0.03347432240843773,
0.7434746026992798,
-0.15108279883861542,
0.11803483963012695,
-1.092209815979004,
0.6282872557640076,
-0.3851788640022278,
0.36864539980888367,
-0.32347601652145386,
-1.0845385789871216,
-1.1338996887207031,
0.7713276147842407,
-0.19565293192863464,
-0.07338353991508484,
-0.8767589330673218,
0.4016333520412445,
-0.19816868007183075,
0.7328914403915405,
-0.7600804567337036,
-0.3038882613182068,
1.0312142372131348,
-0.5443324446678162,
-0.24209454655647278,
0.2264527976512909,
-0.2695429027080536,
-0.3004770874977112,
-0.26697251200675964,
0.35075467824935913,
-0.09948389232158661,
-0.3822612762451172,
0.1799647957086563,
-0.600582480430603,
0.8397595286369324,
0.411182701587677,
0.5986654162406921,
0.3615109324455261,
0.6091974377632141,
0.6501796245574951,
-0.0935993492603302,
0.018733074888586998,
0.45962077379226685,
1.4513192176818848,
-0.12101094424724579,
0.9615911245346069,
0.2653113603591919,
0.08600528538227081,
-0.19438938796520233,
0.42501896619796753,
-0.4280708134174347,
0.929080605506897,
0.36503535509109497,
0.06738495081663132,
0.27241551876068115,
0.4172690212726593,
-0.7323099970817566,
0.025436487048864365,
-0.7812485694885254,
-0.06429257988929749,
-0.40979933738708496,
1.1726458072662354,
-0.037876393646001816,
0.23476773500442505,
-0.11374707520008087,
0.27388256788253784,
0.029175836592912674,
-0.261412113904953,
0.6286792159080505,
0.7835122346878052,
-0.7382477521896362,
-0.635441780090332,
-0.49460652470588684,
0.1894339770078659,
-0.23301362991333008,
-0.12017028778791428,
0.0670505166053772,
0.5987431406974792,
-0.12266099452972412,
0.1935790479183197,
0.265741765499115,
-0.6206753849983215,
-1.0828975439071655,
-0.6772337555885315,
-0.9798858165740967,
-0.22031065821647644,
-0.6419113874435425,
-0.4487417936325073,
-0.12239764630794525,
-0.5406901240348816,
0.7094704508781433,
-0.023693479597568512,
-0.16969214379787445,
0.10027455538511276,
0.5914126038551331,
-0.029842274263501167,
-0.025944041088223457,
0.35680270195007324,
-0.5690487623214722,
0.7952888011932373,
-0.663544237613678,
0.766254723072052,
-0.6232951879501343,
0.36014196276664734,
-0.38524848222732544,
-0.5163965821266174,
0.475046306848526,
0.12150527536869049,
-0.08720497041940689,
0.12319308519363403,
0.5899299383163452,
-0.1392514407634735,
0.3450448513031006,
0.6773334741592407,
-0.8745692372322083,
-0.3773822784423828,
-0.535895586013794,
0.26084646582603455,
0.5378478765487671,
-0.1645861268043518,
0.6689597964286804,
1.0845664739608765,
-0.7716005444526672,
0.033258214592933655,
-0.44279998540878296,
0.25986796617507935,
-0.8255034685134888,
0.9666923880577087,
0.18440614640712738,
-0.012272768653929234,
-0.28624841570854187,
-0.4871009290218353,
-0.8979344964027405,
-0.5386794209480286,
-0.015632811933755875,
0.048940159380435944,
-0.36282268166542053,
1.2813031673431396,
0.5919385552406311,
-1.1594278812408447,
0.5161213874816895,
-0.25314778089523315,
-0.4557711184024811,
0.5481443405151367,
-0.3392237424850464,
-0.0275822002440691,
0.3178957998752594,
-0.7162534594535828,
-0.15088467299938202,
0.25752881169319153,
0.37138813734054565,
0.3530258536338806,
0.2950718104839325,
-1.0032813549041748,
-0.16351930797100067,
0.7663435339927673,
1.145266056060791,
0.08993023633956909,
0.054685045033693314,
0.036492567509412766,
0.23289044201374054,
0.2937239110469818,
-0.0025197542272508144,
0.624270498752594,
0.5007427334785461,
0.2071562260389328,
0.0992022380232811,
0.3868159055709839,
-0.08863761276006699,
-0.26410111784935,
0.2608831226825714,
-0.6597060561180115,
-0.10578367859125137,
0.29265207052230835,
0.47267571091651917,
0.34861913323402405,
-0.5588271617889404,
-0.7873674631118774,
-0.0875442698597908,
0.023827344179153442,
0.4081835448741913,
-1.1132862567901611,
1.0503828525543213,
0.9129045009613037,
-0.1310560703277588,
0.31549179553985596,
0.2428392469882965,
0.6094251871109009,
0.48988819122314453,
0.06629997491836548,
0.8774304389953613,
-0.9196560978889465,
0.1004476547241211,
-0.43213117122650146,
0.781901478767395,
1.655631422996521,
0.5334813594818115,
1.1280694007873535,
0.2520211338996887,
-0.05165198817849159,
-0.683571457862854,
-0.7545584440231323,
-0.01039356179535389,
-0.16811755299568176,
-0.05812591686844826,
-0.4998708665370941,
-0.5712800621986389,
-0.3646286427974701,
0.3285159468650818,
0.26441314816474915,
-0.2872770130634308,
-0.020128490403294563,
0.42814621329307556,
-1.008363962173462,
0.0034497701562941074,
0.2998727560043335,
0.35460013151168823,
0.3517783582210541,
-1.215352177619934,
-0.06735964119434357,
0.2703196704387665,
-0.20576009154319763,
0.48210009932518005,
0.16536641120910645,
-0.4309081733226776,
-0.4734684228897095,
0.7091525793075562,
-0.6218259334564209,
-0.4477345943450928,
-0.2039336860179901,
0.3323422074317932,
0.2902584373950958,
-0.04590145871043205,
0.7676005959510803,
-0.0723511353135109,
0.514755368232727,
0.049939751625061035,
-0.8743282556533813,
-0.14578473567962646,
-0.38212844729423523,
-0.43634122610092163,
0.7924945950508118,
0.3736412823200226,
-1.1282994747161865,
0.23930570483207703,
0.3056848347187042,
-1.0629507303237915,
-0.00246505462564528,
0.6552600860595703,
0.032825570553541183,
-0.07843630760908127,
0.20270399749279022,
0.10066292434930801,
0.46902304887771606,
-0.07092133164405823,
-0.7158037424087524,
0.4582163393497467,
0.12060631811618805,
0.31613728404045105,
1.0597758293151855,
0.19899015128612518,
-0.5666727423667908,
0.2968926727771759,
-0.7773970365524292,
0.6818931698799133,
-0.7256268262863159,
-0.14227518439292908,
-0.7667441964149475,
-0.3580195903778076,
-0.28696492314338684,
0.6320445537567139,
-0.16752749681472778,
-0.4010107219219208,
-0.24880297482013702,
0.2550549805164337,
-1.109631061553955,
-1.3677027225494385,
0.2889552116394043,
-0.2606844902038574,
0.5730208158493042,
0.7693582773208618,
0.04190090298652649,
-0.11958812177181244,
0.5500543117523193,
-0.3623018264770508,
-0.895055890083313,
0.937864363193512,
0.8093861937522888,
0.6699110865592957,
-0.37492403388023376,
0.5026674270629883,
-0.0024175280705094337,
-0.014620540663599968,
0.1111144870519638,
-0.5577589273452759,
0.027329973876476288,
-0.45932403206825256,
-0.9168696999549866,
-1.2503925561904907,
0.11030404269695282,
-0.5828733444213867,
0.2425697147846222,
-0.04562053084373474,
-0.25900253653526306,
0.22376015782356262,
-0.09234727919101715,
-0.0387108139693737,
-0.14554056525230408,
-0.09445112198591232,
-0.795761227607727,
-0.05831511318683624,
0.7673280835151672,
0.5733490586280823,
0.10337778180837631,
-0.5164221525192261,
0.20251904428005219,
-0.7111634016036987,
-0.6152451634407043,
-0.14403997361660004,
-0.2623540461063385,
-0.45166534185409546,
-0.07039694488048553,
-0.33560842275619507,
-0.27989619970321655,
0.32321396470069885,
-0.4121556580066681,
0.22369351983070374,
0.17378239333629608,
0.7312533259391785,
0.37577250599861145,
-0.9805827140808105,
0.8960277438163757,
0.11211998760700226,
-1.7979868650436401,
-0.5584818720817566,
1.2117239236831665,
0.41263580322265625,
0.3683384656906128,
0.06720521301031113,
-1.3405742645263672,
0.041342977434396744,
-0.7631403803825378,
0.3881695866584778,
-0.9143279790878296,
0.7443958520889282,
-0.7654157280921936,
0.14806495606899261,
0.2213078886270523,
0.5308467745780945,
0.6762933731079102,
-0.16593223810195923,
-0.3987087309360504,
-1.2146811485290527,
0.24951615929603577,
0.08846037834882736,
-0.6442568302154541,
-0.7463181614875793,
-0.39903590083122253,
0.21583035588264465,
0.773917019367218,
-0.4747791886329651,
-1.4195977449417114,
0.23590940237045288,
-0.002883764449506998,
-0.062282025814056396,
0.6608610153198242,
-0.958742618560791,
0.06846794486045837,
-0.8210960030555725,
0.6302691102027893,
0.15001030266284943,
0.3305969536304474,
-0.7746358513832092,
-0.2871718108654022,
-0.42140206694602966,
0.2030179798603058,
-0.09566117823123932,
0.02039986662566662,
-0.12261464446783066,
-0.2606896758079529,
0.6121446490287781,
0.14539338648319244,
0.6187923550605774,
-0.18085508048534393,
0.31914135813713074,
0.5424240231513977,
0.1881069540977478,
-0.7740803360939026,
0.46150752902030945,
-0.786029040813446,
-0.8869453072547913,
1.1297292709350586,
-0.18029730021953583,
-0.6636276841163635,
0.9582278728485107,
-0.19788876175880432,
0.8588079214096069,
-0.5616360306739807,
0.5374788641929626,
0.1000034287571907,
0.8960631489753723,
-0.3296746015548706,
0.3080615699291229,
0.02630017325282097,
-0.21048833429813385,
-0.6313425898551941,
0.10943842679262161,
0.05810548737645149,
-0.14316943287849426,
0.6869596242904663,
0.13143417239189148,
-1.0522503852844238,
0.099845290184021,
0.48138996958732605,
0.8677923083305359,
0.2967083752155304,
0.3635287582874298,
-0.3499952256679535,
-1.028786301612854,
-0.39471349120140076,
0.09905020147562027,
0.2679448425769806,
0.1637430489063263,
1.4432121515274048,
0.44431272149086,
-0.19349731504917145,
0.40497100353240967,
-0.06991780549287796,
-0.43766263127326965,
-0.41155585646629333,
1.0763850212097168,
0.4175305962562561,
-0.9968112111091614,
0.3899311423301697,
0.6712778806686401,
-0.9842467308044434,
-0.7622110843658447,
-0.18816165626049042,
-0.20787377655506134,
0.10255049914121628,
-0.4978872239589691,
-0.25822803378105164,
0.3725212812423706,
0.226514533162117,
0.315253883600235,
0.09439685195684433,
-0.5234209299087524,
0.4036102592945099,
-0.3597930669784546,
0.12104997038841248,
-0.4333086907863617,
0.6820933818817139,
1.426390528678894,
-0.1555286943912506,
0.12189453840255737,
-0.4321173429489136,
0.2994071841239929,
-0.23220530152320862,
-0.36204037070274353,
-0.35884469747543335,
0.15534628927707672,
0.071868397295475,
0.19969256222248077,
1.2874205112457275,
-0.18372832238674164,
0.29696962237358093,
-0.15310707688331604,
-0.030265720561146736,
-0.5620614886283875,
-0.4666498601436615,
-0.5982390642166138,
0.1530032604932785,
0.7545388340950012,
0.780609667301178,
0.6785847544670105,
-0.1251508891582489,
1.159745216369629,
-0.5876479744911194,
-0.4044010043144226,
-0.7967846393585205,
-0.091634102165699,
-1.1618045568466187,
-0.1826035976409912,
-0.4487796127796173,
-1.2679226398468018,
0.9364629983901978,
0.4018239974975586,
0.047865234315395355,
0.254046767950058,
-0.11303247511386871,
-0.32678472995758057,
0.30158522725105286,
0.5658101439476013,
-0.3475871682167053,
0.4808198809623718,
-0.3630475401878357,
-0.6416369676589966,
-0.5031959414482117,
-1.0784697532653809,
0.04769394174218178,
1.0566177368164062,
-1.0812960863113403,
0.24734263122081757,
0.3423956632614136,
1.4576613903045654,
-0.19665800034999847,
0.08856265991926193,
-1.0146461725234985,
-0.6056042909622192,
-0.9025111198425293,
0.2714930474758148,
0.08299698680639267,
0.2962733209133148,
0.5024851560592651,
-0.1619361788034439,
0.23211711645126343,
0.7149176001548767,
-0.6157928705215454,
-0.6512523293495178,
-0.016731038689613342,
0.794230580329895,
-0.9530346393585205,
0.6525615453720093,
-0.10776690393686295,
0.8855260014533997,
-0.5997563004493713,
-0.6549522876739502,
-0.8570771217346191,
0.10770886391401291,
-0.3503035008907318,
0.6144524812698364,
-0.3268898129463196,
0.8117597699165344,
-0.024215685203671455,
0.16354860365390778,
-0.4879520535469055,
0.7484537363052368,
0.6649877429008484,
-0.5130887627601624,
-0.686287522315979,
0.14339156448841095,
-0.3651609420776367,
-0.4642336666584015,
0.27422019839286804,
0.13864363729953766,
-0.08245691657066345,
-0.45398879051208496,
0.016440540552139282,
0.11868767440319061,
-0.017153099179267883,
-0.42457032203674316,
-0.5086326599121094,
0.3459445536136627,
0.21872469782829285,
0.48919910192489624,
0.5332711338996887,
-0.49307870864868164,
-0.9705770015716553,
-0.16984349489212036,
-0.9309192299842834,
0.03054407797753811,
0.12347745150327682,
-0.8168820738792419,
0.032840948551893234,
-0.07614937424659729,
-0.6382983326911926,
0.42075440287590027,
0.7154375314712524,
0.5201250910758972,
0.22268249094486237,
-0.17204123735427856,
0.45464619994163513,
0.26855987310409546,
0.22978121042251587,
0.13087280094623566,
0.47976166009902954,
0.3917509913444519,
-0.8200372457504272,
-0.6788755655288696,
-0.7683280110359192,
-0.3101896047592163,
-0.6828508973121643,
0.4962565302848816,
-0.1603260487318039,
-0.25582700967788696,
-0.34442126750946045,
0.126186802983284,
-0.7197421789169312,
-0.1545499563217163,
-0.6422305107116699,
-0.24526329338550568,
0.07250875234603882,
-0.3029129207134247,
0.10729218274354935,
0.34753644466400146,
0.3721276521682739,
-0.05183960497379303,
-0.7789700627326965,
0.7544348239898682,
1.1553363800048828,
-0.5293765068054199,
0.8964862823486328,
0.1860598623752594,
0.15197347104549408,
-0.44665855169296265,
-0.10911989212036133,
0.789385974407196,
0.9554346203804016,
-0.4495876133441925,
0.6605021357536316,
0.31118008494377136,
0.6370244026184082,
0.5433638691902161,
0.011938542127609253,
-0.5919504761695862,
0.5758811831474304,
-0.14749550819396973,
-0.016349539160728455,
0.041047822684049606,
-0.25542721152305603,
0.07470585405826569,
0.3893440365791321,
-0.764583945274353,
-0.18649590015411377,
0.2141290009021759,
0.19471758604049683,
0.11671231687068939,
-0.80316162109375,
1.1966140270233154,
-0.27553921937942505,
-0.448703795671463,
-0.5761991143226624,
0.42530855536460876,
1.2768633365631104,
0.08070386946201324,
-1.2219992876052856,
-0.1564190536737442,
1.1444841623306274,
0.17778106033802032,
-0.11360757052898407,
0.8038365840911865,
-0.2706412672996521,
-0.6595374345779419,
-0.12594887614250183,
0.7190685272216797,
0.6701061725616455,
0.022275151684880257,
0.0875043198466301,
-0.8021770715713501,
-0.9308950901031494,
1.049606204032898,
-0.7261409759521484,
-0.5688238143920898,
0.5531834363937378,
-0.23587624728679657,
-0.3748300075531006,
-0.5412493348121643,
0.3779405951499939,
-0.42493411898612976,
-0.09006145596504211,
0.4238145649433136,
-0.6109349131584167,
-0.12906505167484283,
0.18339616060256958,
-0.47198259830474854,
0.7058629989624023,
-0.24335503578186035,
0.3908381462097168,
-0.04635525122284889,
0.4251919090747833,
1.0409104824066162,
0.39322376251220703,
0.13677877187728882,
-0.5281373858451843,
-0.20242692530155182,
-0.05664028599858284,
-0.2639743983745575,
-0.7903463244438171,
1.0289093255996704,
-0.20099641382694244,
-0.7462832927703857,
0.19828422367572784,
-0.4249262511730194,
-0.5831505656242371,
0.1265665888786316,
-0.781063973903656,
0.4229713976383209,
-0.34188273549079895,
-0.02119917795062065,
1.1167389154434204,
0.882832944393158,
0.23587007820606232,
0.030400311574339867,
-0.29390692710876465,
0.18349330127239227,
0.3287532925605774,
-0.3063603341579437,
0.8947550058364868,
0.25350895524024963,
0.002413576003164053,
-0.45439228415489197,
-1.1012487411499023,
-0.4635414779186249,
-0.6490271091461182,
-0.534946620464325,
-0.6047602295875549,
0.3914770185947418,
0.3419426679611206,
0.3019116520881653,
1.2966140508651733,
-0.6616114974021912,
0.6460719704627991,
-0.30872079730033875,
0.6746605038642883,
0.16287201642990112,
0.3601253032684326,
0.32141855359077454,
0.3468921184539795,
-0.06324926763772964,
0.2949606776237488,
-0.19514960050582886,
0.0509483739733696,
0.21409808099269867,
-0.725804328918457,
0.19832441210746765,
-0.7077735662460327,
-0.5113646984100342,
0.5485138893127441,
0.6528076529502869,
-0.08609212189912796,
-0.5431739687919617,
-0.5608726739883423,
0.1873297244310379,
-0.49363574385643005,
-0.11330229789018631,
-1.3900483846664429,
0.28518491983413696,
-0.1103009507060051,
0.4264959990978241,
0.15723204612731934,
-1.1102359294891357,
3.7296383380889893,
1.329150915145874,
0.3905753791332245,
0.33855417370796204,
0.7618786096572876,
0.7586478590965271,
0.3208838105201721,
-0.6159669160842896,
0.02756264992058277,
0.24848659336566925,
-0.23370453715324402,
-0.12211045622825623,
0.8548697829246521,
0.23774226009845734,
-0.41268739104270935,
-0.037779662758111954,
-1.3913357257843018,
0.3698233962059021,
0.6444310545921326,
-1.1603422164916992,
-1.2792835235595703,
0.6560093760490417,
0.0502936989068985,
-0.9521588683128357,
0.7137026786804199,
0.5110782384872437,
0.05939863249659538,
-0.5600662231445312,
0.3823913633823395,
-0.4041881859302521,
0.1957263946533203,
-0.045000575482845306,
0.7636301517486572,
0.18489280343055725,
-0.43208587169647217,
0.5558555126190186,
0.3958846628665924,
0.05904633179306984,
-0.3961315453052521,
0.9747904539108276,
0.4303545355796814,
-0.23167508840560913,
-0.4642983078956604,
-0.05798538774251938,
-0.7528047561645508,
0.7888855338096619,
-0.659989058971405,
0.08042525500059128,
0.4342275559902191,
-0.034360628575086594,
0.8162742257118225,
-0.5900750160217285,
0.7427517175674438,
-0.2139344960451126,
-0.7112569808959961,
-0.4527343511581421,
0.13837166130542755,
-0.851310670375824,
-0.6990708112716675,
-0.07265610247850418,
0.3217121660709381,
0.05217466875910759,
0.16946472227573395,
0.11862273514270782,
0.06482651084661484,
0.30938851833343506,
0.24860401451587677,
-0.04611675441265106,
-0.5598769783973694,
-0.5283734202384949,
-0.02122046798467636,
-0.39653921127319336,
-0.24217703938484192,
-0.6936982870101929,
0.3677787780761719,
-0.04944233596324921,
-0.43103376030921936,
0.9895378947257996,
-0.846534788608551,
-0.4612201452255249,
-0.34381014108657837,
-0.09304241836071014,
0.07064542919397354,
-0.15878471732139587,
0.8828542828559875,
0.028484273701906204,
-0.008761840872466564,
0.3685976266860962,
-0.6914820671081543,
-0.15017661452293396,
0.7838561534881592,
0.8463928699493408,
0.7941293120384216,
0.15383249521255493,
-0.21220514178276062
] | {"Title": "Response to a population bottleneck can be used to infer recessive selection", "Authors": "Balick Daniel J., Do Ron, Reich David, Sunyaev Shamil R.", "Abstract": "Abstract Here we present the first genome wide statistical test for recessive selection. This test uses explicitly non-equilibrium demographic differences between populations to infer the mode of selection. By analyzing the transient response to a population bottleneck and subsequent re-expansion, we qualitatively distinguish between alleles under additive and recessive selection. We analyze the response of the average number of deleterious mutations per haploid individual and describe time dependence of this quantity. We introduce a statistic, B R , to compare the number of mutations in different populations and detail its functional dependence on the strength of selection and the intensity of the population bottleneck. This test can be used to detect the predominant mode of selection on the genome wide or regional level, as well as among a sufficiently large set of medically or functionally relevant alleles.", "URL": "https://doi.org/10.1101/003491"} |
10.1101/2020.03.24.005603 | [
0.4596821367740631,
0.9193750619888306,
0.5649282336235046,
-0.5354798436164856,
-0.273204505443573,
0.2960546612739563,
-0.2001432478427887,
-0.7212429046630859,
0.4343147873878479,
0.2902999520301819,
0.5151695609092712,
-0.7198643088340759,
0.20377099514007568,
-0.5804149508476257,
-0.01459595002233982,
-0.23302511870861053,
-0.3992021083831787,
-0.8109811544418335,
-0.6434095501899719,
-0.8043327331542969,
0.24535970389842987,
-0.13325545191764832,
-0.6841791272163391,
-0.10321363806724548,
-0.19511140882968903,
0.44333019852638245,
0.02871747501194477,
-0.1851787567138672,
1.618904948234558,
0.4390469789505005,
-0.08728150278329849,
-0.36885035037994385,
0.646550178527832,
-0.9145177006721497,
-0.49290400743484497,
0.09378775954246521,
0.8396657705307007,
0.35004961490631104,
-0.3152461051940918,
-0.48144760727882385,
0.3291361629962921,
0.21252353489398956,
0.09907819330692291,
-0.6096152067184448,
-0.14029917120933533,
0.27826759219169617,
-0.14093026518821716,
-0.2692338526248932,
0.08329907059669495,
-0.3863697946071625,
-0.4221087098121643,
0.4365234375,
0.1052757054567337,
-0.3794885575771332,
0.25422000885009766,
-0.24929241836071014,
0.5137401223182678,
0.2663148045539856,
-0.5972899198532104,
0.1860235035419464,
0.051912106573581696,
-0.285928875207901,
0.6208971738815308,
-1.1604105234146118,
0.5764784216880798,
0.711670994758606,
-0.2264440655708313,
-0.8681485056877136,
-0.21910113096237183,
0.13160432875156403,
-0.9847329258918762,
-0.2375570684671402,
-0.3859168589115143,
-0.879902720451355,
-0.3103516697883606,
-0.33286866545677185,
0.8296879529953003,
0.16710354387760162,
-0.36155351996421814,
0.1550983041524887,
-0.14379127323627472,
0.5211227536201477,
-0.01523195207118988,
0.3188615143299103,
-0.14932924509048462,
-0.717512845993042,
0.8545785546302795,
0.3548726439476013,
-1.1291900873184204,
0.41152626276016235,
-0.5440089106559753,
0.46931853890419006,
0.25366297364234924,
0.038472969084978104,
-0.012071246281266212,
1.029313325881958,
-0.693411648273468,
0.3591865301132202,
0.1800922453403473,
-0.020512402057647705,
0.5240599513053894,
0.786886990070343,
-0.5840430855751038,
0.5819076895713806,
-0.13548032939434052,
0.6793901920318604,
0.36887118220329285,
0.05616409704089165,
-0.4549315869808197,
-0.2979039251804352,
0.8098440170288086,
0.187611386179924,
-0.03305646404623985,
0.23330259323120117,
0.8706876039505005,
0.47939231991767883,
-0.3597237765789032,
0.786237895488739,
-1.1599631309509277,
-0.4969100058078766,
-0.5855243802070618,
-0.0591583251953125,
0.8456534743309021,
-0.04950238764286041,
0.4117937684059143,
-0.10236578434705734,
-0.4344034492969513,
0.5522817373275757,
-0.6731245517730713,
0.0625370442867279,
0.06032320857048035,
-0.27443593740463257,
-0.12066575139760971,
1.0642459392547607,
-0.20521198213100433,
-0.38103973865509033,
-0.1846330761909485,
0.643799901008606,
0.1247066780924797,
-0.6994290947914124,
0.7313517928123474,
0.16120602190494537,
-0.6268870234489441,
1.6142221689224243,
-0.2241058051586151,
0.3622930645942688,
-0.2523903548717499,
-1.407685399055481,
-1.1394789218902588,
0.688239336013794,
-0.056748270988464355,
0.6254069209098816,
-0.8949697017669678,
-1.0678718090057373,
-0.6667690873146057,
0.5279766321182251,
-0.15782177448272705,
-0.250144362449646,
0.18932713568210602,
0.4776184856891632,
-0.07596135884523392,
0.3091679811477661,
0.06474563479423523,
0.2888203263282776,
-0.410389244556427,
0.8550723195075989,
-0.10009399056434631,
-0.07342510670423508,
-0.47329702973365784,
-0.628017246723175,
0.01650841534137726,
0.14416463673114777,
0.053424496203660965,
0.47856709361076355,
0.17543558776378632,
0.719256579875946,
0.6682184934616089,
0.12450980395078659,
0.41077718138694763,
-0.4402557909488678,
0.22158752381801605,
-0.42397379875183105,
0.04802447929978371,
0.33782628178596497,
-0.666909396648407,
0.16384471952915192,
0.3670409917831421,
0.1491776406764984,
-0.7842247486114502,
-0.04393169283866882,
0.34240272641181946,
0.651921808719635,
-0.17240610718727112,
0.5866087675094604,
0.04024193063378334,
0.008436747826635838,
-0.2793097496032715,
-0.25381961464881897,
0.48724687099456787,
-0.29532307386398315,
-0.8600234985351562,
1.0724655389785767,
-0.440991073846817,
-0.2832217216491699,
-0.32867681980133057,
0.2177284061908722,
0.05535731837153435,
0.4902031123638153,
-1.5519863367080688,
0.4277166724205017,
0.6125531792640686,
0.12560604512691498,
-0.3963705599308014,
-0.4161447584629059,
0.15343548357486725,
-0.7832890152931213,
-0.19525112211704254,
0.7200641632080078,
-0.1961188167333603,
0.2023511677980423,
-0.2443767488002777,
-0.6102149486541748,
0.9820843935012817,
0.05693390965461731,
0.43577995896339417,
0.2920469045639038,
0.7521068453788757,
1.1822813749313354,
-0.08929521590471268,
0.02465437725186348,
0.4108327627182007,
0.873107373714447,
-0.6495463848114014,
0.8956728577613831,
0.3029114007949829,
0.42940783500671387,
0.4373382329940796,
0.5820814967155457,
0.20926280319690704,
0.5696897506713867,
0.4194665253162384,
-0.0912671685218811,
0.3679601550102234,
0.6444833874702454,
-0.20222194492816925,
-0.10208107531070709,
-0.666571855545044,
0.48867690563201904,
-0.2542286813259125,
0.24936111271381378,
-0.52513587474823,
0.01167257409542799,
0.2334071397781372,
0.810744047164917,
-0.6592203378677368,
-0.552395761013031,
-0.10601120442152023,
0.09967613220214844,
-0.14867748320102692,
-0.24317991733551025,
-0.4727800786495209,
0.1573818027973175,
0.14217562973499298,
0.5964208841323853,
0.9588486552238464,
0.9420839548110962,
0.18125824630260468,
0.1453108787536621,
-0.24916404485702515,
-0.233926922082901,
-1.2244760990142822,
-0.8664599657058716,
-1.1392956972122192,
-0.3272310793399811,
-0.8561486601829529,
-0.46780797839164734,
0.1808190941810608,
-0.6438397765159607,
0.46539217233657837,
-0.29201990365982056,
0.4692542552947998,
-0.054736413061618805,
-0.03890097141265869,
0.09553022682666779,
0.4340348541736603,
0.29143887758255005,
-0.8528086543083191,
0.8965269327163696,
-0.23854082822799683,
0.4521704614162445,
-0.3128201961517334,
-0.13032136857509613,
0.05473814159631729,
-0.506342887878418,
0.3210638761520386,
-0.2307467758655548,
-0.6841185092926025,
-0.3542736768722534,
-0.01791330799460411,
-1.1876626014709473,
-0.2859531044960022,
-0.10385378450155258,
-0.10126788914203644,
0.1130107045173645,
-0.6041761636734009,
0.46115198731422424,
0.8219872117042542,
-0.15297047793865204,
0.4645262062549591,
0.8966443538665771,
-0.5086941719055176,
0.4126906394958496,
-0.36286330223083496,
0.07776512950658798,
-1.0439915657043457,
0.7529944181442261,
0.7920714020729065,
-0.3864361643791199,
-0.5719900727272034,
-0.7026494741439819,
-1.0290471315383911,
-0.3446948528289795,
-0.35090702772140503,
0.16145098209381104,
-0.2837774455547333,
1.0352243185043335,
0.06543157249689102,
-1.1064954996109009,
-0.019104942679405212,
-0.17297227680683136,
-0.921877920627594,
0.3328639566898346,
-0.311016708612442,
0.19681201875209808,
0.3981448709964752,
-0.26368045806884766,
-0.24004502594470978,
0.24218998849391937,
0.659727931022644,
0.5263158679008484,
-0.12783855199813843,
-1.3380358219146729,
0.5205915570259094,
0.6679045557975769,
0.28848960995674133,
-0.017353342846035957,
0.5264657735824585,
0.23540568351745605,
-0.028318652883172035,
-0.13991248607635498,
0.008973282761871815,
0.4882769286632538,
0.898584246635437,
-0.013087454251945019,
-0.04326135665178299,
0.21275994181632996,
-0.2764244079589844,
0.4763290286064148,
0.6649754643440247,
-0.17800264060497284,
0.18308137357234955,
0.9204424619674683,
-0.2163684070110321,
-0.07382060587406158,
-0.16189637780189514,
-0.49745991826057434,
0.11222892254590988,
0.24712717533111572,
0.49172747135162354,
-0.7820299863815308,
0.814224123954773,
0.3866165578365326,
-0.6207955479621887,
0.4206021726131439,
0.1414165198802948,
-0.6506714224815369,
0.1698359251022339,
-0.2543551027774811,
0.9923702478408813,
-0.9133340120315552,
-0.03371129557490349,
0.509324848651886,
1.2904260158538818,
0.24954243004322052,
0.9901084899902344,
1.2424651384353638,
-0.14964711666107178,
0.2464457005262375,
-0.8624944090843201,
-0.04190155118703842,
-0.20379388332366943,
-0.0842372477054596,
0.10963727533817291,
0.2420262098312378,
-1.0444002151489258,
0.12756328284740448,
-0.2604398727416992,
0.22996096312999725,
0.11049621552228928,
-0.060517966747283936,
1.0732972621917725,
-1.0324656963348389,
0.08718568086624146,
-0.5396100282669067,
0.6822242736816406,
0.1653330773115158,
-1.0139769315719604,
0.061122555285692215,
0.2872508466243744,
-0.9141976833343506,
0.1830686628818512,
-0.04011791571974754,
-0.05703260377049446,
0.2889915108680725,
-0.04132053628563881,
0.010349192656576633,
-0.6351608633995056,
-0.7053449749946594,
-0.15635763108730316,
0.5248926281929016,
0.6087459921836853,
0.38111454248428345,
-1.1398658752441406,
0.849578857421875,
0.45935922861099243,
-0.5652376413345337,
-0.016484377905726433,
-0.22727073729038239,
-0.14765462279319763,
0.528685450553894,
-0.419514924287796,
-0.8603174686431885,
0.534116268157959,
-0.24874718487262726,
-0.5736392736434937,
0.3093591332435608,
0.09343761950731277,
-0.16185659170150757,
0.844765841960907,
-0.1315879374742508,
-0.13915923237800598,
-0.8112367987632751,
0.3404941260814667,
-0.6473878622055054,
0.6055768728256226,
-0.18184956908226013,
0.6435889005661011,
0.5567494630813599,
-0.0756426453590393,
-0.8125187754631042,
0.34376242756843567,
-0.9506529569625854,
0.47778958082199097,
-0.10896752774715424,
-0.23973777890205383,
-0.47641661763191223,
-0.4829556941986084,
-0.6549239158630371,
-0.07952800393104553,
0.21987281739711761,
0.08268051594495773,
-0.5807258486747742,
0.29849594831466675,
-0.8335765600204468,
-1.3809653520584106,
0.8504346013069153,
-0.11659418046474457,
0.5136318802833557,
1.1454368829727173,
0.2893800735473633,
0.1546144336462021,
0.15978485345840454,
0.39299118518829346,
-1.052366852760315,
0.5044481754302979,
0.12332311272621155,
0.09074089676141739,
0.1830054074525833,
-0.1522124707698822,
0.2127876877784729,
-0.27034175395965576,
0.4700768291950226,
-0.3096350431442261,
-0.6924223303794861,
-0.39513880014419556,
-0.3984984755516052,
-1.2533475160598755,
0.34869417548179626,
-1.0849261283874512,
-0.23675917088985443,
0.38035741448402405,
-0.4791150391101837,
0.4435877799987793,
-0.7163701057434082,
0.02332799881696701,
-0.29100364446640015,
-0.2871629595756531,
-0.02925168164074421,
0.8644885420799255,
0.11189465969800949,
1.0792064666748047,
-0.10227791965007782,
-0.8949737548828125,
-0.05206606164574623,
0.1358228325843811,
-0.24194584786891937,
-0.23287808895111084,
-0.5198224186897278,
-0.0710267573595047,
-0.8201123476028442,
-0.3758029639720917,
-0.948858380317688,
-0.08860215544700623,
-0.1397254914045334,
-0.8484192490577698,
0.23124992847442627,
-0.2192811518907547,
0.3711560368537903,
-0.6119450330734253,
0.964857816696167,
0.25978460907936096,
-1.7117172479629517,
-1.115074634552002,
1.0966109037399292,
-0.4537144899368286,
-0.007228354457765818,
-0.1852542608976364,
-0.5552257895469666,
0.08416052907705307,
-0.5940873026847839,
0.21189433336257935,
-0.9471226334571838,
0.05867579206824303,
-0.6774315237998962,
-0.5110253691673279,
0.11094515770673752,
0.3803139328956604,
0.8433117866516113,
0.014828508719801903,
-0.5861712098121643,
-0.3708277642726898,
-0.0885159894824028,
-0.051873669028282166,
-0.946082592010498,
-0.35662445425987244,
0.33219465613365173,
0.14385704696178436,
0.9716485738754272,
-0.21841508150100708,
-1.0932680368423462,
0.00004718394484370947,
0.18882215023040771,
0.7752388119697571,
0.9940592050552368,
-1.0461006164550781,
0.18379545211791992,
0.030026521533727646,
-0.02287864312529564,
0.6345196962356567,
0.16965989768505096,
-0.996918797492981,
0.06973174214363098,
-0.5803913474082947,
-0.22999772429466248,
-0.2920804023742676,
-0.08273616433143616,
0.16906048357486725,
-0.1821218729019165,
0.9380955100059509,
-0.4772533178329468,
0.7243221402168274,
-0.29893070459365845,
-0.22980087995529175,
0.00695381173864007,
-0.13473640382289886,
-0.5702873468399048,
-0.21827271580696106,
-1.0262410640716553,
-0.5938505530357361,
0.5604462027549744,
-0.29757392406463623,
-0.3780449628829956,
0.24185806512832642,
-0.10986588150262833,
0.11589767038822174,
-0.3307958245277405,
0.8234775066375732,
0.8144438862800598,
0.5303805470466614,
-0.3144783675670624,
0.4419993460178375,
-0.15085171163082123,
0.4032876789569855,
-0.4954935610294342,
0.03570304811000824,
-0.38949254155158997,
-0.7504578232765198,
0.5289674401283264,
-0.2178555577993393,
-0.9735455513000488,
0.5283364653587341,
0.189097061753273,
0.31248554587364197,
0.33917883038520813,
0.11355926096439362,
0.1050090566277504,
-0.5385518670082092,
-0.11752068996429443,
0.09626730531454086,
0.22648459672927856,
-0.20522163808345795,
1.1962590217590332,
0.4382680058479309,
0.6173221468925476,
0.8099335432052612,
-0.17617514729499817,
-0.5478205680847168,
-0.4257134199142456,
0.8465079665184021,
-0.1751966029405594,
-0.5909689664840698,
0.28236210346221924,
0.49549779295921326,
-0.839759349822998,
-0.3465556204319,
-0.060345131903886795,
-0.4019509553909302,
-0.38206157088279724,
-0.49622491002082825,
-0.172087162733078,
0.25148481130599976,
-0.6818884015083313,
0.2334122657775879,
-0.3476064205169678,
-0.7583292722702026,
-0.08745234459638596,
-0.3407461941242218,
0.48178401589393616,
-1.4148257970809937,
1.0869344472885132,
1.0659613609313965,
0.2946982979774475,
-0.47152841091156006,
-0.29932329058647156,
0.6017573475837708,
0.06495064496994019,
0.1805395632982254,
0.005526270717382431,
-0.1794481724500656,
-0.3963913917541504,
0.46132007241249084,
0.8043762445449829,
0.05649489536881447,
0.32499220967292786,
0.019224151968955994,
0.43852776288986206,
0.4029630124568939,
-0.8633797764778137,
-0.21772578358650208,
0.6528750061988831,
0.7595311999320984,
0.6751596331596375,
0.12067776173353195,
0.30715787410736084,
1.295878529548645,
0.09907658398151398,
0.11549060046672821,
-1.12568199634552,
0.19210723042488098,
-1.2618861198425293,
-0.13033100962638855,
-0.15409302711486816,
-0.09233073890209198,
0.11467839032411575,
0.1528306007385254,
-0.5114380717277527,
-0.1952504962682724,
-0.49769672751426697,
0.7119343280792236,
-0.6059880256652832,
-0.20197157561779022,
-0.5276978015899658,
0.49156367778778076,
-0.5529728531837463,
-1.0488075017929077,
-0.5401530265808105,
-0.5216144919395447,
0.43647441267967224,
1.005033016204834,
-0.3300838768482208,
0.01702926866710186,
-0.31863710284233093,
0.4301173686981201,
0.08520553261041641,
0.2329818159341812,
-0.8521661162376404,
-0.26439669728279114,
-1.277856469154358,
0.6511038541793823,
-0.006035865284502506,
-0.20913377404212952,
1.0403915643692017,
-0.30594077706336975,
0.6354489922523499,
1.2059462070465088,
-0.33020877838134766,
-1.2935216426849365,
-0.12011542916297913,
0.619627833366394,
-0.8565561175346375,
0.1945504993200302,
-0.763421356678009,
0.46575474739074707,
-1.3747929334640503,
-0.7716178894042969,
0.06817726045846939,
-0.20405668020248413,
-0.19928136467933655,
0.6711133122444153,
0.18630848824977875,
1.3049417734146118,
0.28386473655700684,
0.116872139275074,
-0.2417876422405243,
0.8527319431304932,
0.42036256194114685,
-0.411576509475708,
0.32155874371528625,
0.039900872856378555,
-0.5893886089324951,
-0.7077311277389526,
0.4676351845264435,
0.9880597591400146,
-0.499051034450531,
0.021101152524352074,
-0.26650357246398926,
0.5370692610740662,
-0.26211485266685486,
-0.5705429911613464,
-0.08703458309173584,
0.8492010831832886,
0.5865902900695801,
0.3701978921890259,
-0.10653946548700333,
-1.2806590795516968,
-0.8180041313171387,
-0.030020305886864662,
-1.1474785804748535,
-0.26486653089523315,
0.5532388687133789,
-0.7739775776863098,
0.5539180636405945,
-0.5816615223884583,
-0.2986357808113098,
0.14288711547851562,
1.0490447282791138,
0.9405156970024109,
0.7259892821311951,
0.4550532102584839,
0.06603416055440903,
0.42911913990974426,
-0.3476206064224243,
0.3745439052581787,
0.21635204553604126,
-0.26669469475746155,
-0.566127359867096,
-0.10140804201364517,
-0.47447875142097473,
0.5518509745597839,
0.2925249934196472,
-0.42546021938323975,
-0.39167046546936035,
0.22354277968406677,
0.5336204171180725,
-0.31269779801368713,
-0.4635172486305237,
0.3470514118671417,
-0.13023650646209717,
0.02348102256655693,
-0.4066913425922394,
-0.06376393139362335,
-0.06313315778970718,
0.8647564649581909,
0.6226807832717896,
-0.1185174509882927,
-0.5193224549293518,
0.4830927550792694,
0.792509138584137,
-0.12481271475553513,
1.4302995204925537,
0.5153655409812927,
0.7755854725837708,
-0.23381012678146362,
-0.6039402484893799,
1.1451756954193115,
0.6341192126274109,
0.054785095155239105,
0.2138212025165558,
0.16557468473911285,
0.7231205701828003,
0.7682071924209595,
0.5531169772148132,
-0.7712414860725403,
0.8911402225494385,
0.4633035957813263,
0.15655536949634552,
0.47526055574417114,
-0.6068750023841858,
0.4979669749736786,
-0.15975746512413025,
-0.34769877791404724,
-0.610709547996521,
0.46780550479888916,
-0.15767601132392883,
0.7776937484741211,
-0.6848058104515076,
0.4659823477268219,
-0.6421322822570801,
-1.1438777446746826,
0.04289962351322174,
0.11446434259414673,
0.9523159265518188,
-0.3266058564186096,
0.2346394658088684,
-0.4572586417198181,
0.4245152473449707,
0.16796644032001495,
0.8040358424186707,
1.0142080783843994,
-0.40990957617759705,
-0.08732124418020248,
-0.5069061517715454,
0.6951592564582825,
-0.22111621499061584,
0.5040984153747559,
0.4688044786453247,
-0.9649683237075806,
-0.04483024403452873,
0.8182721138000488,
0.04681560397148132,
-0.6376238465309143,
0.635546088218689,
0.002897188300266862,
-0.28776371479034424,
-0.33381542563438416,
0.2048959881067276,
-0.7337431907653809,
-0.17705444991588593,
0.7216539978981018,
-0.9215825796127319,
-0.2575119137763977,
0.6950027942657471,
-0.0184354018419981,
0.826666533946991,
0.35062289237976074,
0.23579762876033783,
-0.04046354442834854,
1.236993432044983,
1.3083772659301758,
0.4466816484928131,
-0.15106409788131714,
0.13551044464111328,
-0.14524665474891663,
-0.047236159443855286,
-0.2285238653421402,
-0.34345728158950806,
0.3967134952545166,
-0.7209944128990173,
-0.5498399138450623,
-0.1640506088733673,
-0.5454229116439819,
-0.21477101743221283,
0.18422675132751465,
-0.814776599407196,
0.3588857054710388,
-0.26045629382133484,
-0.34708982706069946,
1.096672773361206,
0.5381495952606201,
-0.0864717960357666,
0.012811164371669292,
0.14838343858718872,
-1.0885146856307983,
0.513327419757843,
-1.1299958229064941,
0.826042652130127,
0.17928655445575714,
-0.58365398645401,
-0.3116302490234375,
-1.1975752115249634,
-0.02458110824227333,
-0.15967899560928345,
0.0837118923664093,
0.11214505136013031,
-0.04301139712333679,
0.42785587906837463,
0.2372480183839798,
0.379067599773407,
-0.633520245552063,
0.5007614493370056,
0.6118448376655579,
0.42220041155815125,
-0.29692524671554565,
0.8384734988212585,
0.457628458738327,
0.3946130573749542,
0.031320422887802124,
0.012367763556540012,
-0.5504783987998962,
-0.11776380240917206,
-0.19922856986522675,
-0.5293393731117249,
0.3057715892791748,
-0.5449725985527039,
-0.9349921345710754,
0.3928975462913513,
0.7073621153831482,
-0.3145448863506317,
-0.4821132719516754,
-0.8152803182601929,
0.30265453457832336,
-0.3217015862464905,
0.29802438616752625,
-1.0409841537475586,
0.14366531372070312,
0.47313186526298523,
-0.4720824062824249,
-0.20891886949539185,
-1.2881441116333008,
3.771918773651123,
1.5532495975494385,
0.881240725517273,
0.32031431794166565,
0.9684125185012817,
0.7606989741325378,
0.37530404329299927,
-0.186660036444664,
0.06908656656742096,
-1.045137643814087,
-0.29813963174819946,
0.14293630421161652,
0.16407161951065063,
0.09173829853534698,
-0.0890168696641922,
0.1806010603904724,
-1.5894120931625366,
0.383613258600235,
0.046474356204271317,
-1.17941153049469,
-1.1907083988189697,
0.19313375651836395,
-0.04651876166462898,
-0.4874803423881531,
0.8160073757171631,
0.2418195605278015,
-0.8146306872367859,
0.300412118434906,
-0.2604949176311493,
-0.518663763999939,
-0.3748956620693207,
0.2646036744117737,
0.13439448177814484,
0.17572948336601257,
0.233337864279747,
0.017106536775827408,
0.2799578905105591,
-0.5160270929336548,
0.16162069141864777,
0.4128176271915436,
-0.16946589946746826,
-0.5270879864692688,
-0.23891755938529968,
-0.22875846922397614,
-0.7562577128410339,
0.401902437210083,
-0.6612576246261597,
0.00908114667981863,
0.3685030937194824,
-0.05875706300139427,
0.6358917951583862,
-1.0479533672332764,
0.6420671939849854,
-0.6010297536849976,
-0.20256750285625458,
-0.252801775932312,
-0.5729292631149292,
-1.2564308643341064,
-0.4890481233596802,
0.6397740244865417,
0.14041553437709808,
-0.13526180386543274,
0.011037714779376984,
0.016146663576364517,
0.33354994654655457,
0.38695845007896423,
0.5430046916007996,
-0.1738266497850418,
-0.3919113278388977,
-0.4933856427669525,
0.03479273244738579,
-0.15298783779144287,
0.10917092114686966,
-0.006713035050779581,
0.5001432299613953,
0.2939038872718811,
-0.5477164387702942,
1.3123537302017212,
-0.3615909218788147,
-0.03131018951535225,
0.1473722606897354,
-0.019141312688589096,
0.1592133343219757,
-0.26539239287376404,
0.1989349126815796,
-0.022659871727228165,
-0.8837431073188782,
0.6506390571594238,
-0.44766390323638916,
0.5325412750244141,
0.33778834342956543,
0.27758508920669556,
0.6096338629722595,
0.3706035017967224,
-0.45340919494628906
] | {"Title": "H arvestman : A framework for hierarchical feature learning and selection from whole genome sequencing data", "Authors": "Frisby Trevor S., Baker Shawn James, Mar\u00e7ais Guillaume, Hoang Quang Minh, Kingsford Carl, Langmead Christopher James", "Abstract": "Abstract We present H arvestman , a method that takes advantage of hierarchical relationships among the possible biological interpretations and representations of genomic variants to perform automatic feature learning, feature selection, and model building. We demonstrate that H arvestman scales to thousands of genomes comprising more than 84 million variants by processing phase 3 data from the 1000 Genomes Project, the largest publicly available collection of whole genome sequences. Next, using breast cancer data from The Cancer Genome Atlas, we show that H arvestman selects a rich combination of representations that are adapted to the learning task, and performs better than a binary representation of SNPs alone. Finally, we compare H arvestman to existing feature selection methods and demonstrate that our method selects smaller and less redundant feature subsets, while maintaining accuracy of the resulting classifier. The data used is available through either the 1000 Genomes Project or The Cancer Genome Atlas. Access to TCGA data requires the completion of a Data Access Request through the Database of Genotypes and Phenotypes (dbGaP). Binary releases of H arvestman compatible with Linux, Windows, and Mac are available for download at https://github.com/cmlh-gp/Harvestman-public/releases", "URL": "https://doi.org/10.1101/2020.03.24.005603"} |
10.1101/2020.03.25.007740 | [
-0.0627792477607727,
-0.09851919859647751,
0.6179879903793335,
0.13680437207221985,
0.14067816734313965,
0.022495461627840996,
-0.2944904863834381,
-0.410160630941391,
0.054616719484329224,
0.915229856967926,
0.9022536277770996,
-0.5919570922851562,
0.3703380227088928,
-0.3682750165462494,
0.08828555792570114,
0.4924730360507965,
-0.41670817136764526,
-0.1401214748620987,
-0.38544222712516785,
-0.29085156321525574,
-0.06950818002223969,
-0.25791269540786743,
-0.6019959449768066,
0.16257525980472565,
-0.15478567779064178,
-0.30729982256889343,
-0.5426563024520874,
-0.21485424041748047,
0.6372998952865601,
0.9338625073432922,
0.023277584463357925,
-0.8161731958389282,
0.6849421262741089,
-1.1767953634262085,
0.23218552768230438,
-0.19366252422332764,
0.2592526376247406,
0.14273355901241302,
-0.3124036192893982,
-0.4944121241569519,
0.5413472652435303,
0.2093336284160614,
0.49172309041023254,
-0.14877814054489136,
0.14819879829883575,
-0.5240325331687927,
-0.6405412554740906,
-0.18631091713905334,
-0.8105153441429138,
-0.21333983540534973,
-0.18914951384067535,
0.5125493407249451,
1.1990535259246826,
0.08615212142467499,
-0.5417762994766235,
0.008043192327022552,
0.030173635110259056,
-0.098385289311409,
-1.0118248462677002,
0.7353664636611938,
0.09767252951860428,
-0.8858334422111511,
0.18325428664684296,
-0.8808935880661011,
1.242226481437683,
1.4888890981674194,
-0.5559245347976685,
-0.18167319893836975,
0.3917665183544159,
-0.6048188805580139,
-0.6672558188438416,
0.5174780488014221,
-0.8938615322113037,
-0.289771169424057,
-0.3379988372325897,
0.026430021971464157,
0.20035988092422485,
-0.28103283047676086,
-0.4188588857650757,
-0.021170461550354958,
-0.3481597900390625,
0.0416482612490654,
-0.23011434078216553,
0.07719041407108307,
-0.02596549689769745,
-0.25488507747650146,
-0.7853691577911377,
0.3378954231739044,
-0.15404164791107178,
0.7550796270370483,
-0.08039654046297073,
0.6864125728607178,
-0.06187596544623375,
-0.9439664483070374,
-0.5219696164131165,
0.5992004871368408,
-0.48970526456832886,
-0.24483029544353485,
-0.20747284591197968,
-0.23043854534626007,
0.1756857931613922,
0.33952319622039795,
-0.4230234920978546,
0.4835740327835083,
0.08888646960258484,
0.8109506964683533,
0.7917582392692566,
-0.11629082262516022,
-0.9136661887168884,
-1.1539961099624634,
0.2336496263742447,
-0.17968474328517914,
-0.828406572341919,
0.25816741585731506,
0.31389641761779785,
0.3266553282737732,
-0.13561809062957764,
0.31844136118888855,
-0.3032897412776947,
-0.4000471234321594,
0.024353332817554474,
-0.18377192318439484,
0.8689523935317993,
0.1466396003961563,
0.3579557538032532,
-0.18760009109973907,
-0.05759423226118088,
0.42924755811691284,
-0.376311331987381,
-0.44895070791244507,
-0.059297848492860794,
-0.006938947830349207,
-0.2789544463157654,
0.7219709157943726,
0.08464320003986359,
0.6894616484642029,
-0.31864187121391296,
0.09421225637197495,
0.3109228312969208,
-0.8907495737075806,
0.422750324010849,
-0.3708761930465698,
0.06305286288261414,
1.261239767074585,
0.11177776008844376,
-0.16853231191635132,
-0.2942890524864197,
-0.7515434622764587,
-0.040903352200984955,
0.6507021188735962,
-0.814582884311676,
0.6733695268630981,
-0.4123309254646301,
-0.849919319152832,
-0.04072415828704834,
0.7749342322349548,
-0.06269204616546631,
1.074561357498169,
0.05853978171944618,
-0.3065526485443115,
-0.5206776857376099,
0.057001400738954544,
0.15716934204101562,
0.5130437612533569,
0.12362107634544373,
-0.08157239109277725,
-0.7850911021232605,
-0.09564649313688278,
-0.22769524157047272,
-0.3365691304206848,
0.42965981364250183,
-0.48513615131378174,
-0.3385147452354431,
0.8726704716682434,
0.2279510498046875,
0.360944539308548,
1.0488859415054321,
-0.3663320243358612,
0.29732945561408997,
0.6396898627281189,
0.01980847306549549,
-0.5133730173110962,
0.5760107636451721,
1.187970757484436,
-0.15804046392440796,
-0.0014351541176438332,
-0.4462742805480957,
0.5022168755531311,
0.07592350989580154,
-0.5063133239746094,
-0.22891481220722198,
1.0503621101379395,
-0.40890443325042725,
-0.2518632709980011,
-0.2655019164085388,
-0.11367493122816086,
-0.9707614779472351,
0.636067807674408,
-0.5818159580230713,
-0.13011401891708374,
-0.13187992572784424,
-0.25547724962234497,
-0.13131089508533478,
0.0604611337184906,
-0.8667401075363159,
0.4692188799381256,
0.36864668130874634,
0.3522077202796936,
-0.3961898684501648,
0.5130658745765686,
0.29556506872177124,
-0.9582992792129517,
-0.14095467329025269,
-0.04230349138379097,
-0.12952476739883423,
-0.8242081999778748,
-0.7299306392669678,
0.055879317224025726,
0.5502030849456787,
0.32728204131126404,
0.6080614328384399,
-0.34315046668052673,
0.2131938934326172,
0.4371488094329834,
0.013250072486698627,
0.5006508231163025,
0.3657437860965729,
0.12106650322675705,
-0.21006371080875397,
-0.8942632079124451,
0.5225763916969299,
0.9344872236251831,
-0.3670397996902466,
0.38957780599594116,
0.37085187435150146,
0.9610503911972046,
0.30557700991630554,
0.31519144773483276,
1.1344976425170898,
-0.1308051496744156,
0.4588181674480438,
0.2861274480819702,
0.8730480074882507,
0.8401079177856445,
0.43227139115333557,
-0.06695347279310226,
-0.4209898114204407,
0.26573944091796875,
-1.0126398801803589,
0.6428362131118774,
-0.35822993516921997,
0.9991610050201416,
0.716822624206543,
0.43627211451530457,
0.0780566930770874,
0.05401560291647911,
0.1827213168144226,
-0.11011028289794922,
-0.6459622383117676,
-0.3976495563983917,
0.406035453081131,
0.14385715126991272,
-0.3253861665725708,
0.48703718185424805,
0.9846838116645813,
0.9524915814399719,
-0.49415746331214905,
0.0027238926850259304,
-0.4995518922805786,
-0.8051066994667053,
-1.0943057537078857,
-0.6050601005554199,
-0.7931421995162964,
-0.8307492733001709,
-0.5093030333518982,
0.0702802762389183,
1.0321543216705322,
-0.43471840023994446,
1.4170972108840942,
0.6437522172927856,
0.2664235830307007,
0.3257621228694916,
-0.2357551008462906,
0.32198965549468994,
0.15547345578670502,
0.3716464936733246,
-0.950140118598938,
0.20570850372314453,
-0.38865700364112854,
-0.09365014731884003,
-0.6879223585128784,
0.3419424593448639,
-0.11845757812261581,
-0.6799458265304565,
0.2908010482788086,
-0.43941882252693176,
-0.10861179232597351,
-0.43671903014183044,
-0.12866853177547455,
-0.08743639290332794,
-0.026716774329543114,
0.44357141852378845,
-0.28110066056251526,
0.20361009240150452,
-0.725956916809082,
1.0237468481063843,
0.5214075446128845,
0.4820348024368286,
0.46266743540763855,
0.1535414755344391,
0.00830772239714861,
0.7020688056945801,
0.0037210765294730663,
-0.1855759173631668,
-0.28704726696014404,
0.6983460783958435,
0.7980206608772278,
0.8055493235588074,
0.40618667006492615,
-0.8566902875900269,
-0.7719159722328186,
0.31850603222846985,
0.23237428069114685,
-0.7315531373023987,
-0.33550047874450684,
0.8802383542060852,
0.3504708707332611,
-0.8763817548751831,
0.1898002028465271,
0.12668751180171967,
-0.7542451620101929,
0.04968423768877983,
0.1197146326303482,
-0.22228911519050598,
-0.34767502546310425,
-0.05625917389988899,
0.03458501026034355,
0.5927876234054565,
0.04930903762578964,
0.31223541498184204,
0.19361716508865356,
-0.06697116047143936,
0.5612309575080872,
0.32353824377059937,
0.06543257087469101,
0.14954188466072083,
0.016309328377246857,
-0.003332032822072506,
-0.6284879446029663,
0.11761711537837982,
-1.0439413785934448,
-0.10814918577671051,
0.37954947352409363,
0.5588825345039368,
-0.05470050126314163,
0.14289692044258118,
-0.5578705072402954,
-0.35935667157173157,
-0.4945342242717743,
0.26605424284935,
-0.06743558496236801,
0.3046994209289551,
-0.43652820587158203,
-0.06119260936975479,
-0.8627477288246155,
-0.5155054926872253,
0.67451012134552,
0.530466616153717,
0.09391701221466064,
-0.8899176120758057,
0.4846249520778656,
0.6595261096954346,
-0.49737340211868286,
0.2648104727268219,
-0.12808668613433838,
0.3766079545021057,
0.6209008097648621,
0.6482120156288147,
1.175656795501709,
-0.3705918490886688,
0.13848434388637543,
0.30839717388153076,
1.1265833377838135,
0.6308875679969788,
0.43570318818092346,
0.8744163513183594,
-0.5497559309005737,
0.4038197696208954,
0.060378897935152054,
0.03653649240732193,
-0.217279851436615,
-0.05294962227344513,
-0.007265536114573479,
-0.020385466516017914,
0.2689441740512848,
0.07319358736276627,
0.04410017281770706,
0.09883586317300797,
0.5150232315063477,
-0.20606763660907745,
0.22385819256305695,
0.10254620015621185,
-0.5226837992668152,
0.5003043413162231,
0.17063429951667786,
-0.1359456479549408,
-0.49981170892715454,
0.04890695959329605,
0.32192155718803406,
0.10044361650943756,
-0.8903856873512268,
0.07343751937150955,
0.11619291454553604,
0.16426405310630798,
-0.15252861380577087,
0.6056296229362488,
-0.5356444716453552,
-0.25622251629829407,
-0.43979376554489136,
-0.11621768027544022,
-0.5270571708679199,
-0.44326210021972656,
-0.19614030420780182,
0.406928688287735,
0.4087495803833008,
-0.30773699283599854,
0.5512297749519348,
-0.494085431098938,
0.22397750616073608,
0.1076708436012268,
0.2594854533672333,
-0.26208993792533875,
-1.2162718772888184,
0.04962301626801491,
-1.0412031412124634,
0.5984886884689331,
0.6813800930976868,
-0.21461094915866852,
1.0878050327301025,
-0.16096973419189453,
-0.23641879856586456,
-1.0635303258895874,
0.1331462860107422,
-0.8876612186431885,
0.11596978455781937,
0.07202520966529846,
0.8372464776039124,
0.46699509024620056,
0.11886249482631683,
0.07224496454000473,
0.5584728717803955,
-0.8881516456604004,
0.7273794412612915,
-0.7861875295639038,
-0.40928423404693604,
0.14882682263851166,
-0.036579616367816925,
-0.20780453085899353,
-0.07265659421682358,
0.31718897819519043,
0.23365013301372528,
-0.539979875087738,
0.2361857295036316,
-0.35169801115989685,
-0.0342593751847744,
0.8685782551765442,
-0.6727899312973022,
0.8650829792022705,
1.4565532207489014,
-0.24258659780025482,
0.27694496512413025,
0.10054700076580048,
0.15812067687511444,
-0.33232101798057556,
0.10009431838989258,
-0.33337128162384033,
-0.023481106385588646,
0.49510490894317627,
-0.6195976734161377,
-0.2489294558763504,
-0.14008234441280365,
0.08829221874475479,
-0.8900867700576782,
0.1162613108754158,
0.24154996871948242,
-0.12386196106672287,
-0.2579616904258728,
0.21182481944561005,
-0.46360766887664795,
-0.10051076859235764,
-0.13112559914588928,
-0.39030933380126953,
0.20140030980110168,
0.08341246843338013,
-0.5139025449752808,
-0.3185046911239624,
0.3060278296470642,
-0.787343442440033,
0.2449798285961151,
-0.733701229095459,
1.0724610090255737,
0.37154364585876465,
-1.254697561264038,
0.7248526215553284,
-0.2278570681810379,
-1.2718161344528198,
-0.6291141510009766,
-0.3113841414451599,
-0.3633693754673004,
-0.307262659072876,
0.34565749764442444,
0.3339017629623413,
-0.7114113569259644,
-0.7113394141197205,
0.12312875688076019,
0.20888136327266693,
0.8331202864646912,
0.18874534964561462,
-0.0868566632270813,
0.5298706293106079,
0.5916234254837036,
-0.4625142812728882,
-0.6230811476707458,
0.8028737902641296,
-0.6458273530006409,
-0.17124946415424347,
0.10547447949647903,
-1.545745849609375,
-0.30012786388397217,
0.021476682275533676,
-0.054214004427194595,
-0.9578862190246582,
0.026480956003069878,
-0.7755436897277832,
-0.1717638522386551,
0.08918280154466629,
0.3599754571914673,
0.46436089277267456,
-0.19013135135173798,
-0.22062388062477112,
-0.5621107220649719,
-0.35708755254745483,
0.16209709644317627,
0.2738448977470398,
-0.7079238891601562,
-1.0179334878921509,
-0.48785698413848877,
0.5355595946311951,
-0.16822409629821777,
0.07128157466650009,
-0.1465514600276947,
0.006105189211666584,
0.4306451976299286,
0.09455247223377228,
-0.156143456697464,
-0.3527752459049225,
0.30594325065612793,
0.5814571380615234,
-0.07572249323129654,
-0.15725499391555786,
-1.098450779914856,
-0.27677667140960693,
-0.7296314239501953,
0.45297402143478394,
0.19904926419258118,
-0.08263077586889267,
-0.20338644087314606,
-0.2783282399177551,
0.8482877016067505,
-0.372465044260025,
0.08045241236686707,
0.24331419169902802,
0.3198014497756958,
-0.3368486762046814,
0.13485798239707947,
-0.16143806278705597,
-0.06191021949052811,
-0.7908744215965271,
-1.2707912921905518,
0.9058957099914551,
0.08236424624919891,
-0.026387155055999756,
0.0832272469997406,
-0.028408952057361603,
-0.22242306172847748,
-0.9813404083251953,
0.7192596793174744,
0.6230688691139221,
-0.8140307068824768,
-0.572147011756897,
0.5626020431518555,
0.2602244019508362,
-0.29132941365242004,
-0.9742208123207092,
0.34480422735214233,
-0.42267507314682007,
-0.27178919315338135,
-0.25231486558914185,
-0.3577713668346405,
-0.6525009274482727,
0.1902320683002472,
0.7490490078926086,
0.8118297457695007,
0.20899313688278198,
1.2280778884887695,
-0.2174910008907318,
-0.2613770067691803,
-0.2536775469779968,
0.30639752745628357,
0.2712912857532501,
0.1930096447467804,
0.6096088290214539,
0.15610992908477783,
0.213490828871727,
-0.25578561425209045,
0.18888944387435913,
0.12199290096759796,
-0.24932917952537537,
1.0407663583755493,
0.1898520588874817,
-0.6352481245994568,
0.6317517757415771,
0.011623434722423553,
-0.6108593344688416,
-0.8608716726303101,
-0.11687730997800827,
0.060515597462654114,
-0.2525804936885834,
0.05216124281287193,
-0.2914084494113922,
-0.37365490198135376,
-1.2582130432128906,
0.5012788772583008,
-0.4851923882961273,
-0.5240235328674316,
-0.22495347261428833,
-0.9242992401123047,
-0.534583568572998,
0.1821814775466919,
-0.4769046902656555,
1.3335986137390137,
-0.29419851303100586,
-0.14575277268886566,
-0.31061652302742004,
-0.020428171381354332,
-0.19974008202552795,
-0.25924238562583923,
0.6346648335456848,
-0.980651319026947,
0.02413913607597351,
-0.31025177240371704,
0.16397298872470856,
0.1761971414089203,
1.249318242073059,
0.2685496509075165,
0.22830693423748016,
0.37839722633361816,
-0.6031225323677063,
0.12896260619163513,
0.48473748564720154,
1.2026923894882202,
0.21063973009586334,
-0.11150987446308136,
-0.3741845488548279,
0.07209524512290955,
-0.3690411150455475,
0.006887654773890972,
-0.9628965854644775,
0.12233472615480423,
-0.829613983631134,
-0.21064230799674988,
-0.365144282579422,
-1.2556777000427246,
0.6417459845542908,
-0.056933701038360596,
-0.4680761992931366,
-0.06691800057888031,
-0.8902020454406738,
0.7331772446632385,
0.14630934596061707,
0.39545127749443054,
-0.19686147570610046,
0.07783786952495575,
-0.823591411113739,
-0.4481102228164673,
-0.25268393754959106,
-0.24785365164279938,
-0.4592932462692261,
0.9348726272583008,
-0.3150336444377899,
-0.15481822192668915,
-0.8072710037231445,
0.7241691946983337,
-0.5196353793144226,
0.23775802552700043,
0.2115773856639862,
-0.8556187152862549,
-0.5695200562477112,
-0.16399222612380981,
-0.18554510176181793,
0.6295939087867737,
0.7474859952926636,
-0.5999330282211304,
0.17875723540782928,
0.07836473733186722,
-0.42023733258247375,
-0.5053486824035645,
-0.37747156620025635,
0.24393829703330994,
-0.6193263530731201,
-0.6092085242271423,
-0.3131183683872223,
0.16310039162635803,
-1.3104841709136963,
-0.34915488958358765,
-0.627712070941925,
0.23224231600761414,
0.36568525433540344,
-0.12520796060562134,
0.10789740085601807,
1.1140984296798706,
-0.019903309643268585,
0.21080546081066132,
-0.24828119575977325,
-0.28369393944740295,
0.3134499192237854,
-0.13376347720623016,
0.5912334322929382,
0.4704945385456085,
0.23063510656356812,
-0.18589648604393005,
-0.16016121208667755,
0.7190026640892029,
-0.42152413725852966,
-0.05169563367962837,
0.30176815390586853,
0.33840829133987427,
-0.16065898537635803,
-0.4372135102748871,
-0.9566258788108826,
0.18873991072177887,
0.3948899805545807,
-0.5290212631225586,
-1.0282859802246094,
0.015827221795916557,
-0.5340259075164795,
-0.04157578572630882,
-0.4381972849369049,
-0.5760340094566345,
-0.3082534968852997,
-0.16325531899929047,
0.19377663731575012,
-0.12550947070121765,
-0.8678120970726013,
-0.0043720221146941185,
0.4427207112312317,
0.32317468523979187,
-0.524470865726471,
-0.12327137589454651,
-0.03583594784140587,
0.02999601513147354,
-0.293306440114975,
-0.07062831521034241,
0.039642397314310074,
-0.2929005026817322,
-0.507697582244873,
-0.923892617225647,
0.28034210205078125,
0.12715034186840057,
-0.09826484322547913,
-0.6502394080162048,
-0.3062523603439331,
0.005771940108388662,
0.6964302659034729,
0.15970748662948608,
-1.297978401184082,
-0.13308176398277283,
-0.5758072137832642,
0.2693319022655487,
-0.4697214663028717,
-0.2632732689380646,
-0.1785164475440979,
0.4174078702926636,
0.11356434971094131,
-0.2288328856229782,
-0.12332959473133087,
-0.08659806102514267,
0.5519301295280457,
-0.6204177737236023,
0.039219897240400314,
0.05042407289147377,
0.6217126846313477,
-0.17726236581802368,
-0.86014723777771,
0.8496679067611694,
0.6675004363059998,
0.9039649367332458,
0.6327803730964661,
0.3555487394332886,
0.36934298276901245,
0.816730797290802,
0.7046422362327576,
-0.4507722854614258,
-0.032355230301618576,
0.4775831401348114,
-0.1287239044904709,
-0.19838900864124298,
0.14364062249660492,
0.3344368040561676,
0.5801799893379211,
0.7478465437889099,
-0.07253888249397278,
0.38137054443359375,
0.11711535602807999,
0.2937982678413391,
0.0583774670958519,
-0.15870417654514313,
-1.0168863534927368,
-0.2882945239543915,
0.6865384578704834,
0.016645973548293114,
0.6934313774108887,
0.46373647451400757,
-0.3932740092277527,
0.10861783474683762,
0.5771476030349731,
0.28052911162376404,
-0.3072938621044159,
0.4053771495819092,
-0.7954434156417847,
-0.2453208565711975,
-0.29940176010131836,
0.733769953250885,
-0.23520728945732117,
0.7114482522010803,
0.09445525705814362,
-0.3834248185157776,
-0.015158498659729958,
0.8725687265396118,
-0.9662766456604004,
-0.5855495929718018,
0.031850699335336685,
0.013911992311477661,
-0.7494460940361023,
-0.7166796326637268,
0.6412845253944397,
0.3301416337490082,
0.0934828594326973,
0.8568587303161621,
-0.7089931964874268,
-0.09300865978002548,
0.32666608691215515,
0.3602614998817444,
0.4811460077762604,
-0.040970876812934875,
-0.07667483389377594,
-0.578345537185669,
0.6656434535980225,
0.1475280225276947,
0.23253846168518066,
-0.5704525113105774,
0.580583930015564,
-0.30684322118759155,
-0.3721369504928589,
0.17148007452487946,
-0.042398590594530106,
0.7119305729866028,
0.030856365337967873,
-0.16666725277900696,
0.34575745463371277,
0.2267311066389084,
-0.6376151442527771,
-0.5813843607902527,
0.06437832862138748,
0.4434967339038849,
-0.5967444181442261,
-0.1467723399400711,
0.9186176657676697,
-0.0495680570602417,
0.5937450528144836,
-0.3864920139312744,
-0.5097711086273193,
-0.3121311366558075,
0.07698945701122284,
-0.8451205492019653,
0.5836895704269409,
-0.4368976950645447,
-0.16901469230651855,
0.29926782846450806,
-0.0756322517991066,
-0.5147576332092285,
-0.21902908384799957,
-0.5799703598022461,
-0.9140815734863281,
0.23848409950733185,
0.19049867987632751,
1.6461598873138428,
0.24991977214813232,
-0.5628551840782166,
0.022069456055760384,
0.26351088285446167,
0.7597734332084656,
-0.02329273521900177,
0.7378349900245667,
0.014387689530849457,
0.194496750831604,
0.31825190782546997,
0.33763810992240906,
0.5885411500930786,
-0.4705735743045807,
0.22362104058265686,
-0.3187238872051239,
0.2348567247390747,
-0.449447363615036,
-0.38171905279159546,
0.41379737854003906,
-0.06659854203462601,
-0.3954983353614807,
0.08277174085378647,
0.186235249042511,
-0.2799721658229828,
-0.5556731224060059,
0.7651386260986328,
-0.1577681303024292,
0.05478249490261078,
0.3998721241950989,
0.28783589601516724,
0.08012236654758453,
-1.7047646045684814,
4.120491027832031,
1.351525902748108,
1.0652003288269043,
0.49042537808418274,
0.47418007254600525,
0.10334745794534683,
0.34043750166893005,
-0.4790861904621124,
-0.3102007210254669,
-0.38249045610427856,
0.18636535108089447,
-0.054685525596141815,
0.5935671329498291,
-0.4261073172092438,
0.2107618749141693,
0.7383082509040833,
-0.8722812533378601,
-0.4055057764053345,
-0.17373625934123993,
-1.0025649070739746,
-0.2351246178150177,
-0.3487943708896637,
0.169806569814682,
-0.012193573638796806,
0.4583502411842346,
0.321959525346756,
0.08295940607786179,
0.11484228074550629,
0.3973264694213867,
-0.3200546205043793,
-0.7580792903900146,
-0.65669184923172,
0.6662296652793884,
0.46840575337409973,
-0.197204127907753,
0.9762247204780579,
0.7486572861671448,
-0.3402136564254761,
-0.3306555151939392,
0.6853227615356445,
0.19720350205898285,
-0.13976329565048218,
0.3879581391811371,
-0.27815937995910645,
-0.37758228182792664,
0.16318710148334503,
-1.0299278497695923,
0.8344383239746094,
0.005726394709199667,
-0.3784744441509247,
0.595592200756073,
-0.9699383974075317,
-0.04503132775425911,
0.11835774034261703,
-1.3698173761367798,
-0.2469468116760254,
0.2509441375732422,
-0.5219594240188599,
-0.3828921914100647,
0.42656075954437256,
0.7562503218650818,
0.5051827430725098,
-0.6109603643417358,
0.05881637707352638,
0.22799049317836761,
0.7855576276779175,
0.5325164794921875,
1.2408559322357178,
-0.21820586919784546,
-0.8724442720413208,
0.04950924962759018,
-0.4613657593727112,
-0.18579748272895813,
-0.21306787431240082,
0.6998226642608643,
-0.05529984086751938,
-0.5607076287269592,
0.5190504193305969,
0.5321147441864014,
0.2559948265552521,
0.812562882900238,
0.3488774001598358,
-0.948510468006134,
-0.0018566081998869777,
0.42371949553489685,
0.49559512734413147,
0.4327389597892761,
-0.12790486216545105,
-0.034958336502313614,
0.3962068259716034,
0.8638189435005188,
-0.4252987205982208,
0.6310832500457764,
-0.5699259042739868,
-0.007715129759162664
] | {"Title": "Conformational states of the cytoprotective protein Bcl-xL", "Authors": "Ryzhov P., Tian Y., Yao Y., Bobkov A. A., Im W., Marassi F. M.", "Abstract": "ABSTRACT Bcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anti-cancer therapy and for studies aimed at understanding its structure and activity. While Bcl-xL is active primarily at intracellular membranes, most studies have focused on soluble forms of the protein lacking both the membrane-anchoring C-terminal tail and the intrinsically disordered loop, and this has resulted in a fragmented view of the protein\u2019s biological activity. Here we describe how these segments affect the protein\u2019s conformation and ligand binding activity in both its soluble and membrane-anchored states. The combined data from nuclear magnetic resonance (NMR) spectroscopy, molecular dynamics (MD) simulations, and isothermal titration calorimetry (ITC) provide information about the molecular basis for the protein\u2019s functionality and a view of its complex molecular mechanisms. SIGNIFICANCE The human protein Bcl-xL is a key regulator of programmed cell death in health and disease. Structural studies, important for understating the molecular basis for its functions, have advanced primarily by deleting both the long disordered loop that regulates its activity and the C-terminal tail that anchors the protein to intracellular membranes Here we describe the preparation and conformations of full-length Bcl-xL in both its water-soluble and membrane-anchored states. The study provides new biophysical insights about Bcl-xL and its greater Bcl-2 protein family.", "URL": "https://doi.org/10.1101/2020.03.25.007740"} |
10.1101/2020.03.25.003517 | [-0.4589359760284424,0.48145928978919983,-0.6737005710601807,0.5921944379806519,-0.2613259553909302,(...TRUNCATED) | "{\"Title\": \"Structural Disconnection of the Tool Use Network After Left Hemisphere Stroke Predict(...TRUNCATED) |
End of preview. Expand
in Dataset Viewer.
README.md exists but content is empty.
Use the Edit dataset card button to edit it.
- Downloads last month
- 37