Which of the following would be most likely causing methotrexate therapy failure in ectopic pregnancy treatment.: (A) Multiparous woman, (B) Ectopic size > 2.5 cm, (C) Previous history of ectopic pregnancy, (D) Serum β hcG level of 9000 mIU / mL.
Answer is D. With methotrexate therapy, serum β-hcG levels should decline. If β-hcG rises then it is failure of medical management.