False statement about MODY is -: (A) Age < 25 years, (B) Impaired secretion of insulin, (C) Responds to sulfonylureas, (D) Insulin dependent
Answer is D. Maturity-onset diabetes of the young (MODY) is characterized by autosomal dominant inheritance, early onset of hyperglycemia (usually <25 years; sometimes in neonatal period), and impaired insulin secretion. It is non insulin requiring diabetes and can be managed by diet and sulfonylurea (paicularly HNF-1a and HNF-4a forms). Reference : page 806-7 Davidson's Principles and practice of Medicine 22nd edition