Methemoglobinemia is associated with:: (A) Aicaine, (B) Prilocaine, (C) Bupivacaine, (D) Mepivacaine
Answer is B. A unique systemic side effect associated with a specific local anesthetic is the development of methemoglobinemia after the administration of large doses of prilocaine. In general, 600-mg doses are required for the development of clinically significant levels of methemoglobinemia in adults. Ref: Miller's anesthesia-7th ed, Chapter 30.