Nifedipine and beta-blocker are given together -: (A) To decrease pedal edema due to nifedipine, (B) To overcome increased sympathetic activity of nifedipine, (C) Anti CHF action of propranolol, (D) Antiarrhythmic effect of nifedipine
Answer is B. Ans. is 'b' i.e., To overcome increased sympathetic activity of Nifedipine b-Blocker is given along with Nifedipine because a) Reflex tachycardia (Increased sympathetic activity) caused due to Nifedipine, is prevented by b-blocker. b) b-blockers cause dilatation of coronary aeries by unopposed a-mediated vasoconstriction. Nifedipine causes coronary vasodilatation and opposes the spasm caused by b-blockers. The tendency of b-blocker to cause ventricular dilatation is counteracted by Nifedipine.