Most sensitive antibody for SLE:: (A) Anti-nuclear, (B) Anti-ds DNA, (C) Anti-Smith, (D) Anti-histone
Answer is A. Autoantibodies in Systemic Lupus Erythematosus (SLE) Antibody Clinical Utility Antinuclear antibodies Best screening test/Most sensitive Anti-ds DNA Specific, correlate with disease activity, nephritis, vasculitis Anti-Sm Most Specific for SLE, marker for CNS lupus Anti-RNP Not specific for SLE Anti-Ro/La (SS-A) Sicca syndrome, neonatal lupus with congenital hea block Anti-histone Drug-induced lupus