Which among the following is associated with BRCA mutation carrier status: (A) Mucinous borderline ovarian tumor, (B) High grade pelvic serous carcinoma, (C) Endometroid ovarian cancer, (D) Sertoli - leydig ovarian tumor
Answer is B. High - grade pelvic serous carcinoma includes all high grade serous tumors arising from ovary, fallopian tube, and or peritoneum. As many as 30% of these cancers have BRCA mutations.