Osmotic damage is operative in all of the following complications of diabetes mellitus EXCEPT: (A) The formation of cataracts, (B) Insulin receptor deficiency, (C) Microaneurysms in retinal vessels, (D) Peripheral neuropathy
Answer is B. Osmotic damage is inoperative in insulin- receptor deficiency. Insulin-receptor deficiency is the result of an increase in adipose, which down regulates receptor synthesis, and chronic elevation of glucose (glucose toxicity), which renders the receptors less receptive to insulin.