A one year old child having leucocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involve-: (A) Enucleation, (B) Chemotherapy followed by local dyes, (C) Direct laser ablation using photodynamic cryotherapy, (D) Scleral radiotherapy followed by chemotherapy
Answer is A. *Tumor involving less than half of the globe- Multimodal therapy (chemoreduction followed by local destruction). *Tumor involving half or more of the globe - Enucleation. Ref: Wills Eye hospital at las of Clinical ophthalmology p.269.