All are drugs causing cholestasis with inflammation of bile ducts: , EXCEPT:: (A) Erythromycin, (B) Amoxycillin clavulanic acid, (C) Trimethoprim sulphamethoxazole, (D) Trimethoprim sulphamethoxazole Astemizole
Answer is D. Drugs producing cholestasis with inflammation of the poal tracts: Erythromycin (paicularly the estolate salt), Trimethoprim-sulfamethoxazole Amoxicillin-clavulanic acid Terbinafine. Clinical features are ahralgias, rash, and peripheral eosinophilia cholestasis resolves within several months following discontinuation of the drug. Ref:Sleisenger and Fordtran's,E-9,P-329