High plasma protein binding of a drug results in: (A) Less drug interaction, (B) High volume of distribution, (C) Decreased glomerular filtration, (D) Lowers duration of action
Answer is C. * Most drugs bind to plasma proteins in a reversible fashion without translating into a pharmacological response. (Plasma proteins are hence called Silent Receptors) * Acidic drugs bind to Albumin, Basic drugs to alpha1 acid- glycoprotein. * Binding of the drug to plasma protein affects the pharmacokinetic handling of drug by the body. Ref:- HL & KK Sharma's Principles of Pharmacology 3rd Ed; Pg Num:- 48