Which of these is characteristic of amyloidosis-: (A) Beta pleated, metachromosis, PAS + ve, (B) Congophilic, beta pleated, PAS +ve, (C) Beta pleated, fibrillary, congophilic, (D) Alpha pleated, small fibrils
Answer is C. Robbins and Cotran pathologic basis of disease South Asia edition. *by electron microscopy all types amyloid consist of continuous non branching fibrills.X Ray crystallography and infrared spectroscopy demonstrate a characteristic cross-beta-pleated shear conformation .this conformation is responsible for distinctive Congo red staining and birefringence of amyloid.