A drug X has affinity to bind with albumin and Y has 150 times more affinity to bind with albumin than X. TRUE statement is-: (A) Drug X will available more in tissues, (B) Drug Y will be more available in tissues, (C) Free conc. of drug X in blood will be more, (D) Toxicity of Y will be more
Answer is A. Ans. is 'a' i.e., Drug X will be available more in tissues Highly plasma protein bound drugs are largely restricted to the vascular compament, So drug Y will remain in the vascular compament and drug X will available more in tissues.