Clomiphene citrate is not known to produce which of the following effects in a young female of 30 years of age (child bearing age group)?: (A) Hot flushes, (B) Ovulation, (C) Decreased FSH and LH secretion, (D) Polycystic ovaries
Answer is C. * Clomiphene citrate is an antagonist of estrogen in the peripheral tissues. Due to this propey, it can cause hot flushes. * Due to decreased action of estrogen, feedback pituitary inhibition is blunted resulting in increased secretion of LH and FSH. * It can cause polycystic ovaries and multiple pregnancy (hyperstimulation syndrome).