Anti-diabetic effect of sulfonylureas is by reducing:: (A) Glucagon production, (B) Insulin secretion, (C) Tissue sensitivity to insulin, (D) Tissue sensitivity to glycogen
Answer is A. Ans. (A) Glucagon production(Ref: KDT 8/e p294)Sulfonylureas act byIncreasing insulin release from pancreas (not by decreasing insulin secretion), so 'option b' ruled out.A minor action reducing glucagon and increasing somatostatin release has been demonstrated.