All of the following factors tend to increase the volume of distribution of a drug EXCEPT:: (A) High plasma protein binding, (B) Low ionization at physiological pH values, (C) High lipid solubility, (D) High tissue binding
Answer is A. - Factors affecting drug distribution

   Lipid solubility - Higher the solubility, higher the distribution
   Ionization at physiological pH - Higher the ionization, lower the distribution
   Degree of plasma protein binding - More the binding, less the distribution
   Affinity for different tissues - Higher affinity, higher distribution
   Regional blood flow - More the flow, more the distribution
   Fat: lean body mass ratio (changes with age) - Increases with age 
   Disease like CHF, uremia, cirrhosis