False about Gaucher's disease: (A) Beta Glucocerebrosidase defective, (B) Cherry red spots on fundoscopy, (C) Erlenmeyer's flask deformity, (D) Tarate resistant acid phosphatase -ve
Answer is D. Three biochemical markers of gaucher disease Angiotensin-conveing enzyme ( ACE ) Tarate-resistant acid phosphate ( TRAP ) Chitotriosidase ( CHITO ) These marker are elevated in active disease, these are useful indicators of disease progress and response to enzyme replacement therapy So gaucher disease is basically Tarate-resistant acid phosphatase positive as the disease is being treated the levels of TRAP gradually declines