Barbiturates act on which step of mitochondrial respiratory chain?: (A) Compelx 1 to co-enzyme Q, (B) Compelx 2 to co-enzyme Q, (C) Co-enzyme Q to compelx 3, (D) Cytochrome C to compelx 4
Answer is A. 1. Complex I to Co-Q specific inhibitorsAlkylguanides (guanethidine), hypotensive drugRotenone, insecticide and fish poisonBarbiturates (amobarbital), sedativeChlorpromazine, tranquilizerPiericidin, antibioticRef: DM Vasudevan Textbook of Medical Biochemistry, 6th edition, page no: 234