Which of the following is a rho-kinase inhibitor?: (A) Ranolazine, (B) Fasudil, (C) Nicorandil, (D) Amiloride
Answer is B. Drug MOA FASUDIL- Used for treatment of Angina. NETARSUDIL- Approved for Glaucoma treatment. RHO KINASE INHIBITOR(Causes vasodilation) RANOLAZINE FA metabolism inhibition + Late Na+channel blocker. NICORANDIL NO releaser + K+channel opener. AMILORIDE Epithelial Na+ channel blocker