What is the condition affecting this newborn with facial dysmorphisms and the features shown below?: (A) Edward's syndrome, (B) Turner's syndrome, (C) Alagile syndrome, (D) William's syndrome
Answer is A. The newborn with facial dysmorphism, index finger overlapping other fingers, and rocker bottom feet are suggestive of Edward&;s syndrome (Trisomy 18). Clinical features of Edward&;s syndrome: Hypeonia Microcephaly/Micrognathia Eighteen trisomy/Elongated skull Digit overlapping with a closed fist Webbing of 2nd and 3rd toes Absent intellect (severe developmental delay)/Absent radii/Ahrogryposis Rocker bottom feet Cardiac Disorders (Ventricular septal defect, patent ductus aeriosus, atrial septal defect) and kidney, death. Smaller lower jaw (Micrognathia), sho sternum, small nipples Ref: Nelson textbook of pediatrics 21st edition Pgno: 663,664