In atherosclerosis, increased LDL in monocyte macrophage due to:: (A) LDL receptors on macrophage, (B) LDL receptors on endothelium, (C) Lipids in LDL get oxidized, (D) All of the above
Answer is C. Ans. (c) Lipids in LDL get oxidized(Ref: Robbins 9th/pg 496; 8th/pg 500)With chronic hyperlipidemia, lipoproteins accumulate within the intima, there they aggregate and become oxidized by free radicals produced by inflammatory cells.