Glibenclamide is preferred over chlorpropamide in the treatment of diabetes mellitus because the latter is more likely to cause:: (A) Dilutional hyponatremia, (B) Alcohol intolerance, (C) Cholestatic jaundice, (D) All of the above
Answer is D. Chlorpropamide can cause: Jaundice Disulfiram like reaction Increase ADH Hyponatremia Increase Insulin Sulfonylureas Meglitinides 1st Generation : Chlorpropamide Tolbutamide - Nateglinide - Repaglinide 2nd generation: Glipizide Glicanide Glibenclamide