What is true about thalidomide: (A) It exes antitumour activity in some solid malignant tumours, (B) It exes antileprotic action, (C) It ameliorates cancer associated cachexia, (D) All of the above
Answer is C. Thalidomide It is reintroduced as immunomodulator. uses:- 1)Angiogenesis inhibitor antitumour activity 2)anxiolytic 3)antiemetic 4)adjuvant analgesic/antipyretic propey 5 )improves cancer associated cachexia 6) used in erythema nodosum leprosum 7) multiple myeloma Mech of action:- It acts by suppressing TNFa and by modulating IL-2. contraindication:- In Pregnancy due to phocomelia(seal like limbs). Ref:- kd tripathi; pg num:-877