A middle aged man with chronic renal failure is diagnosed to have sputum-positive pulmonary tuberculosis. His creatinine clearance is 25 ml/min. All of the following drugs need modification in doses except:: (A) Isoniazid, (B) Streptomycin, (C) Rifampicin, (D) Ethambutol
Answer is C. Ans. (C) Rifampicin(Ref: Katzung 11/e p826, KDT 8th/e p818)Rifampicin is secreted in bile, so it does not require dose adjustment in renal failure