Which of the following enzymes is coded by X-chromosome?: (A) alpha-L-Iduronidase, (B) Iduronate sulfatase, (C) b-Galactosidase, (D) Hyaluronidase
Answer is B. option b - Iduronate sulfatase is coded by X-chromosome Mucopolysaccharidoses Rare inborn errors in the degradation of glycosaminoglycans; Characterized by mental retardation and/or skeletal abnormalities. Classified under lysosomal storage disorders. Hunter syndrome inherited - X-linked recessive mode deficiency of enzyme Iduronate sulfatase. All the other MPS are inherited in autosomal recessive mode.