Intrinsic cell wall defect of RBCs is feature of -: (A) Paroxysmal nocturnal hemoglobinuria, (B) Sickle cell anemia, (C) Hemophilia, (D) All of the above
Answer is A. Paroxysmal nocturnal hemoglobinuria is a disease that results from acquired mutations in the phosphatidylinositol glycan complementation group A gene (PIGA), an enzyme that is essential for the synthesis of ceain membrane associated complement regulatory proteins. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:642