BRAF V600E mutations are seen in all of the following Except: (A) Langherhan's cell histiocytosis, (B) Erdheim Chester disease, (C) Ovarian carcinoma, (D) Grade II astrocytoma
Answer is D. BRAF V600E (valine conveing to glutamate at the 600th position)is seen in the following cancers:Langerhan's cell histiocytosisHairy cell leukemiaMalignant melanomaPilocytic astrocytoma (WHO Grade I astrocytoma)Ovarian carcinomaEndometrial carcinomaColorectal carcinomaPapillary carcinoma thyroidErdheim Chester disease