In renal disease albumin is first to appear in urine because: (A) Of its high concentration in plasma, (B) Has molecular weight slightly greater than the molecules normally getting filtered, (C) High albumin : globulin ratio, (D) Tubular epithelial cells are sensitive to albumin
Answer is B. Ans. (b) Has molecular weight slightly greater than the molecules normally getting filtered(Ref: Ganong, 25th ed/p.677)Glomerular membrane permits neutral substances up to 4 nm in diameter. Substances greater than 8nm diameter are totally excludedAlbumin size is 7 nm. So, it has molecular weight slightly greater than the molecules normally getting filtered