Which of the following does not cross the cell membrane: (A) Glucose-6-phosphate, (B) Glucose, (C) Nitrous oxide, (D) Carbon monoxide
Answer is A. Glucose-6-phosphate 
"Glucose-6-phosphate cannot diffuse out of muscle cells".             —Pankaj Naik

Glucose-6-phosphate cannot diffuse out of the cell as such. First, it has to be converted to glucose by glucose-6-phosphatase which then diffuse out of the cells. This occurs in liver. Thus, glucose can be used by other tissues.

Muscle cells does not contain glucose-6-phosphatase, glucose-6-phosphate cannot be converted to glucose and glucose-6-phosphate can only by utilized as a source of energy by only muscle itself.