Which of the following mechanisms is not responsible for complications in DM: (A) Non enzymatic glycosylation, (B) Protein Kinase C activation, (C) Disturbance in polyol pathway, (D) Chronic inflammation
Answer is D. The things responsible for chronic complications of DM are 1)Formation of Advanced glucation end products 2) Activation of Protein Kinase C 3)Oxidative stress and disturbance in Polyol pathways . Possible complications include: Cardiovascular disease. ... Nerve damage (neuropathy). ... Kidney damage (nephropathy). ... Eye damage (retinopathy). ... Foot damage. ... Skin conditions. ... Hearing impairment. ... Alzheimer's disease Ref: Robbins and cotrans 9e Pg 1116