A female patient presented with a firm mass of 2 x 2 cms in the upper outer quadrant of the breast. She gives a family history of ovarian carcinoma. The investigation that needs to be done to assess for mutation is :: (A) p53, (B) BRCA-2, (C) Her 2/Neu gene, (D) C-myc gene
Answer is B. Ans. is 'b' BRCA 2 "In women with hereditary breast - ovarian cancer, two susceptibility loci have been identified:BRCA -1 - located on chromosome 17 andBRCA - 2 - located on chromosome 13" - Harrison, 15/e, p620