What is the cause of hypercoagulation in nephrotic syndrome:: (A) Loss of antithrombin III (AT III), (B) Decreased fibrinogen, (C) Decreased metabolism of vitamin K, (D) Increase in Protein C
Answer is A. Thrombotic and thromboembolic complications are common in nephrotic syndrome due to loss of anticoagulant factor (e.g. antithrombin III, protein C and S) combined with increased platelet activation. Renal vein thrombosis is most often a consequence of this hypercoagulative state. There is also increased synthesis of fibrinogen in the liver.