A 62-year-old female was scheduled for mechanical ventilation for respiratory failure. She was administered pancuronium as a muscle relaxant before intubation. Which of the following statement is accurate regarding pancuronium?: (A) Tetanic tension is poor, (B) Muscle fasciculations are observed at the onset, (C) Autonomic ganglia are stimulated, (D) Predominantly histamine release
Answer is A. Answer: a) Tetanic tension is poorNon-depolarizing muscle relaxants act as pharmacological antagonists at the skeletal muscle end-plate.It acts by competitive antagonism.These agents show post-tetanic potentiation, while the tetanic tension declines rapidly.Response to the tetanic stimulus is unsustained with non-depolarizing muscle relaxants, whereas it is sustained during phase I block with depolarizing muscle relaxants.