True statement regarding Barrett's esophagus: September 2011: (A) Patient present with severe symptoms, (B) Normal pH profile, (C) Increased risk of squamous cell carcinoma, (D) Metaplastic change in the lining mucosa of the esophagus
Answer is D. Ans. D: Metaplastic change in the lining mucosa of the esophagusBarrett's esophagus is a metaplastic change in the lining mucosa of the esophagus in response to chronic gastro-esophageal refluxEsophageal cancer:Impoant predisposing factors:- Excess alcohol- Smoking- Chronic achalasia- Tylosis- Barrett's esophagus- Plummer Vinson syndromeFeatures:- Progressive dysphagia (MC)- Weight loss- WeaknessEsophagoscopy is diagnosticChemotherapy:- Limited role- Cisplatin- Bleomycin- 5-FluorouracilMC type: Squamous cell CaMC site: Lower endMC site of adenoCa: Lower end.MC site of squamous cell Ca: Middle third