with worst prognosis-: (A) 8/21 translocation, (B) Inversion 16, (C) Normal cytogenetics, (D) Monosomy 7
Answer is D. Monosomy 7 or paial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia (MDS) and acute myelogenous leukemia (AML) has worst prognosis Ref Davidson 23rd edition pg 789