What is TRUE about clomiphene?: (A) Enclomiphene is anti-estrogenic, (B) Pregnancy rate is comparable to placebo, (C) Significantly increases sperm counts in oligospermic men, (D) 1 - 2% increase in rate of twin pregnancy
Answer is A. Clomiphene citrate Trans enclomiphene 62%: anti-estrogenic Cis zuclomiphene citrate 38% : mildly estrogenic This Primarily acts at the receptor in Hypothalamus rather than the Ovarian and Pituitary axis. Blockade increases the stimulus to the pituitary to produce more FSH. -Antagonises the beneficial actions of estrogens on the endometrium and hence a supplementation of estrogen is required in patients on higher doses of clomiphene for ovulation induction -6-12% increase in rate of twins Oligospermia relief is not the best benefit of Clomiphene...statistically, because roughly 10-15% only are benefited with this in oligospermia reversal.