A biopsy was performed for a patient with recurrent chalazion involving the upper lid. The most likely diagnosis on histopathology is:: (A) Sebaceous cell carcinoma, (B) Basal cell carcinoma, (C) Squamous cell carcinoma, (D) Malignant Melanoma
Answer is A. Ans. (a) Sebaceous cell carcinomaRef: Kanski 7/e, p. 21, 4Sebaceous Gland Carcinoma* Typically arises from meibomian glands or glands of ZeisQ* Most frequently arises from the upper eyelids[?] where meibomian gland are most frequent (in contrast to basal cell and squamous cell carcinoma)* Highly malignant with mortality of 5-10%* Elderly females are typically affected.* Nodular SGC masquerades a 'chalazion' and hence any patient with recurrent chalazion with an unusual consistency should undergo a full thickness resection and histological examination to exclude SGC.