Wof agent is used to prevent hemorrhagic cystitis caused by cyclophosphamide and ifosfamide: (A) Busulfan, (B) Carmustine, (C) Mesna, (D) Niacin
Answer is C. To prevent hemorrhagic cystitis mesna is routinely given with the drugs. Mesna is a -SH compound that is excreted in urine--binds and inactivates the vasicotoxic metabolites(Acrolein) of ifosfamide and cyclophosphamide. Ref:- kd tripathi; pg num:-860