Drug given for metoclopramide induced dystonic reaction is:: (A) Pheniramine, (B) Promethazine, (C) Chlorpromazine, (D) Prochlorperazine
Answer is B. Ans. (B) Promethazine(Ref: KDT 8th/e p180)"Acute muscle dystonia caused by antiemetic-antipsychotic drugs is promptly relieved by parenteral promethazine or hydroxyzine" This is based on central anti-cholinergic action of the drugs.Promethazine is a first generation anti-histaminic which has maximum penetration of blood brain barrier and maximum anticholinergic activity.