Toxic megacolon is most commonly associated with: (A) Ulcerative colitis, (B) Crohn's disease, (C) Whipple's disease, (D) Reiter's disease
Answer is A. inflammation and inflammatory mediators can damage the muscularis propria and disturb neuromuscular function leading to colonic dilation and toxic megacolon TEXT BOOK OF ROBBINS BASIC PATHOLOGY NINTH EDITION PAGE.590-591