Which antiepileptic drug can lead to this adverse effect:: (A) Phenytoin, (B) Carbamazepine, (C) Valproate, (D) Lamotrigine
Answer is A. Ans. (A) PhenytoinThe figure shows the gum hypertrophy which is caused by phenytoinThe mechanism of action of antiepileptic drugsMain mechanismDrugNa Channel blockersPhenytoinCarbamazepineLamotrigineValproateStimulate GABA-BZD Cl channel complesBarbituratesBenzodiazepinesInhibit GABA transaminaseVigabatrinInhibit GAT-1TiagabineAct on SV2ALevetiracetamOpen K+ ChannelsRetigabineBlock NMDA receptorsFelbamateBlock AMPA receptorsPerampanelBlock L type Ca ChannelsEthosuximide