All of the following drugs are useful in nephrogenic diabetes insipidus except: (A) Amiloride, (B) Indomethacin, (C) Chlorpropamide, (D) Thiazide diuretics
Answer is C. The polyuria and polydipsia of nephrogenic DI are not affected by treatment with standard doses of DDAVP. Treatment with conventional doses of a thiazide diuretic and/or amiloride in conjunction with a low-sodium diet and a prostaglandin synthesis inhibitor (e.g., indomethacin) usually reduces the polyuria and polydipsia by 30-70% and may eliminate them completely in some patients. ref : Harrisons 20th ed 2279.