What is the mechanism of action of levetiracetam?: (A) Antagonist of GABAA receptor, (B) Bind to synaptic vesicular protein SV2A, (C) Inhibit voltage gated Ca+ channel, (D) Inhibit Na+ channel
Answer is B. Levetiracetam is an anti-epileptic drug that works by binding to SV2A, a ubiquitous synaptic vesicle integral membrane protein, which functions as a positive effector of synaptic vesicle exocytosis. Binding to SV2A in the vesicle reduces the release of the excitatory neurotransmitter glutamate. It is used for treatment of focal seizures GTCS, JME