Which of the following prokinetic drugs produces extrapyramidal side effects?: (A) Metoclopramide, (B) Cisapride, (C) Domperidone, (D) All of the above
Answer is A. (Ref: KDT 6/e p643, 644) Metoclopramide and domperidone act by blocking D2 receptors. Metoclopramide can cross BBB whereas domperidone cannot. Therefore, metoclopramide can produce extra-pyramidal adverse effects while domperidone is devoid of it. Cisapride acts as 5HT4 agonist. It can cause torsades de pointes.