Regarding synthesis of triacylglycerol in adipose tissue, all of the following are true, EXCEPT:: (A) Synthesis from Dihydroxyacetone phosphate, (B) Enzyme Glycerol kinase plays an impoant role, (C) Enzyme Glycerol 3 phosphate dehydrogenase plays an impoant role, (D) Phosphatidate is hydrolyzed
Answer is B. Glycerol 3 phosphate may be derived from glycerol by action of Glycerol kinase or from glycolytic intermediate DHAP (Dihydroacetone phosphate) by the action of glycerol 3 phosphate dehydrogenase. The enzyme glycerol kinase is not expressed in adipose tissue and hence glycerol cannot be utilized for provision of glycerol 3 phosphate. Ref: Harper's Illustrated Biochemistry 27th/210, 211, 226; Introduction to Nutrition and Metabolism By David A. Bender, 1997, Page 145.