Wiskott Aldrich syndrome true is -: (A) Raised IgE, (B) Reduced IgM, (C) Reduced IgA, (D) CD4 and CD8 defect
Answer is B. In Wiskott-Aldrich syndrome serum IgM level is low but IgG & IgA levels are normal or elevated. Isohemagglutinins are absent in the serum. The humaral defect appears to be specific inabilityvto respond to polysaccharide antigens. Ref: Ananthanarayan & Panikers textbook of microbiology 9th edition pg.no. : 174