Primary biliary cirrhosis is most commonly associated with______: (A) Systemic sclerosis, (B) Sjogren syndrome, (C) Ulcerative colitis, (D) Pancreatitis
Answer is B. Primary Biliary Cirrhosis Autoimmune disorder Clinical manifestation - obstructive jaundice F > M Antibody seen in antimitochondrial ab which is formed against E2 subunit of PDH enzyme. Interlobular bile ducts are actively destroyed by lymphoplasmacytic inflammation with or without granulomas.