Cardiotoxicity of bupivacaine -: (A) Depressed pacemaker activity, (B) Toxic compound damaging myocardial cells, (C) Depressed neural control on hea, (D) Vascular thrombosis and Myocardial ischemia
Answer is A. Ans. is 'a' i.e., Depressed pacemaker activity o Local anaesthetics block cardiac sodium channels and thus depress abnormal cardiac pacemaker activity, excitability, and conduction. At extremely high concentrations, local anaesthetics can also block calcium channels.