Characteristic skin lesion in Peutz -Jeghers syndrome is: (A) Freckles, (B) Lentigens, (C) Adenoma sebaceum, (D) Cafe -au- lait macules
Answer is B. Peutz Jegher syndrome. Peutz-Jeghers syndrome- Autosomal dominant - Lentigens (increased melanocytes leading to hyperpigmented macules) - Site of lentigen - Perioral(lips),Buccal mucosa - Associated with GI polyp. (MC : Jejunal hamaoma)Freckles /ephelides* It is increased localized melanogenesis.* Normally seen in fairer skin colour (Skin type I,II)* Become dark on sun exposure Adenoma Sebaceum is seen in Tuberous sclerosis aka epiloia Cafe au lait macules is seen in Neurofibromatosis (dark color lesion over lighter skin).