Which one of the following is a potent stimulus for the production of erythropoietin?: (A) Alpha interferon, (B) Interleukin-3, (C) Hypoxia, (D) Hypercarbia
Answer is C. Hypoxia oring the production of hemoglobin F both direct effects on globin gene expression, as well as up-regulated production of erythropoietin. Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No:526