Which of the following is not the source of cytosolic NADPH ?: (A) Isocitrate dehydrogenase, (B) ATP citrate lyase, (C) Malic enzyme, (D) G6PD
Answer is B. Answer. B. ATP citrate lyaseNADPH is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.The major source of NADPH in animals and other non-photosynthetic organisms is the pentose phosphate pathway.The key enzymes in these processes are: NADP-linked malic enzyme, NADP-linked isocitrate dehydrogenase, NADP-linked glutamate dehydrogenase and nicotinamide nucleotide transhydrogenase.