Rofecoxib was withdrawn due to:: (A) lschemic hea disease, (B) Renal complication, (C) Liver adenoma, (D) Gastric ulcer
Answer is A. celecoxib,etoricoxib,parecoxib are available in India.Rofecoxib and valdecoxib were withdrawn within a few years of marketing for increasing cardiovascular risk by increasing the levels of TXA2 which increases platelet aggregation ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION;KD TRIPATHI;PAGE NO 205