25-year-old woman is being treated for a laceration to the forearm. Local anesthesia is used prior to suturing. An allergic reaction is most likely to occur with wof local anesthetics: (A) Lidocaine, (B) Procaine, (C) Mepivacaine, (D) Bupivacaine
Answer is B. The clinically useful LAs are weak bases with amphiphilic propey. A hydrophilic secondaryor teiary amine on one side and a lipophilic aromatic residue on the other are joined by an alkyl chain through an ester or amide linkage. Ref :- kd tripathi; pg num:-360,361