The detection rate of Down syndrome with first-trimester screening with NT, PAPP-A, and hCG is: (A) 64-70%, (B) 80-84%, (C) 94-96%, (D) 99%
Answer is B. Selected Down Syndrome Screening Strategies and Their Detection Rate: Screening test Detection rate Quadruple screen 80-82% First-trimester screen NT alone 64-70% NT, hCG, PAPP-A 80-84% Integrated screening 94-96% Sequential screening Stepwise 92% Contingent 91% Cell-free DNA 91%