Enlargement of pituitary tumor after adrenalectomy is called as:: (A) Nelson syndrome, (B) Steel-Richardson syndrome, (C) Hamman-Rich syndrome, (D) Job's syndrome
Answer is A. Nelson Syndrome: Nelson syndrome refers to a spectrum of symptoms ansd signs arising from an adrenocoicotropin (ACTH)- secreting pituitary macroadenoma after a therapeutic bilateral adrenalectomy The spectrum of clinical features observed relates to the local effects of tumors on surrounding structures , the secondary loss of other pituitary hormones, and the effects of the high serum concentrations of ACTH on the skin Ref: Harrison 19th edition PGno: 2273