In Unconjugated hyperbilirubinemia, the risk of kernicterus increases with the use of: (A) Ceftriaxone, (B) Phenobarbitone, (C) Ampicillin, (D) Sulphonamide
Answer is D. Sulfonamides (also called sulfa drugs) are a group of antibiotics that kill bacteria. Sulfonamides may unbind bilirubin from albumin, which increases blood levels of bilirubin. The unbound bilirubin can cross into the brain and cause kernicterus. Reference: GHAI Essential pediatrics, 8th edition