Furosemide should not be administered with NSAIDS because?: (A) Prevent platelet aggregation, (B) Inhibit prostacyclin synthesis, (C) Decrease sodium reabsorption, (D) Increase the secretion of furosemide in urine
Answer is B. NSAIDs diminish the action of high ceiling diuretics by inhibiting the PG synthesis in the kidney, through which furosemide and related drugs act on the kidney. Antihypeensive action of thiazides and furosemide is also diminished by NSAIDs. REF -Essentials of medical pharmacology, K.D Tripathi, 6th edition, page 568