Which is the best anti-hypeensive drug in pulmonary hypeension?: (A) Bosentan, (B) Amlodipine, (C) Frusemide, (D) Digoxin
Answer is A. Endothelin receptor antagonist Bosentan is approved by US FDA and improves exercise tolerance in 6-minute walk test. Amlodipine Not approved by US FDA and only 20% respond to CCB in the long term. Diuretics Will worsen PAH Digoxin Used in CHF and no role in PAH