Which of the following anaesthetic drugs is contraindicated in chronic renal failure –: (A) Morphine, (B) Fentanyl, (C) Pethidine, (D) Atracurium
Answer is C. Pethidine (Meperidine) is metabolized to form normeperidine (long half life) which is excreted by the kidney. Administration of pethidine to a patient with Chronic Renal Failure causes toxic accumulation of this metabo­lite and is hence contraindicated.