Which diuretic be considered appropriate for combining with ACE inhibitors?: (A) Spironolactone, (B) Eplerenone, (C) Hydrochlorothiazide, (D) Amiloride
Answer is C. Thiazides, loop diuretics produce hypokalemia which can be compensated with hyperkalemia produced by ACE inhibitors Potassium-sparing diuretics like spironolactone, eplerenone, amiloride - produce hyperkalemia- so not to be used with ACE inhibitors ( Essentials of medical pharmacology, K.D Tripathi, 6 th edition, page 568 )