A 56 year old Chronic smoker, mass in bronchus resected. Most useful immunohistochemical marker to make a proper diagnosis would be ?: (A) Cytokeratin, (B) Vimentin, (C) Epithelial membrane cadherin, (D) Leucocyte common antigen
Answer is A. o Mass in bronchus in a old chronic smoker suggest bronchogenic carcinoma. The marker of carcinoma, on immunohistochemistry, is cytokeratin.o Other epithelial markers for carcinoma are :-Epithelial membrane antigen (EMA) :- Breast, lung and Kidney's adenocarcinoma.Carcino-embryonic antigen :- Carcinomas of GIT, pancreas, lung, breast, uterus and ovary.