Fifth clinical sign i.e., loss of function (functio laesa) was added by:: (A) Rudolf Virchow, (B) Elie Metchinkoff, (C) Louis Pasteur, (D) George Bernard
Answer is A. Acute inflammation Four cardinal signs of inflammation was given by Celsus. Rubor (redness) Tumor (swelling) Calor (heat) Dolor (pain). These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function (functio laesa), was added by Rudolf Virchow in the 19th century. Metchinkoff described process of phagocytosis.