Which is a finding in lymphoid tissues in individuals with common variable hypogammaglobulinemia?: (A) Decreased B cell count, (B) Increased B cell count, (C) Normal B cell count, (D) Absent B cells
Answer is C. Common Variable Immunodeficiency Near Normal number of B cells in blood & LN Unable to differentiate to plasma cells Intrinsic B cell defects - defective CK receptor BAFF Also abnormal T cell regulation of B cells Both sexes equally; manifest in childhood or adolescence Presents as Recurrent sinopulmonary pyogenic infections Recurrent herpes V infection Persistent diarrhoea by G Lamblia RA Lymphoid malignancy