Which of the following antihistaminic is free of arrhythmogenic potential?: (A) Terfenadine, (B) Fexofenadine, (C) Loratadine, (D) Ebastine
Answer is C. Loratidine Loratidine is paially metabolized by CYP3A4 to an active metabolite with a longer T1/2 of 17 hours but in contrast to terfenadine/astemizole, it has not produced cardiac arrhythmia in overdose.