Which of the following statement is true regarding Atazanavir:-: (A) Effective against only HIV-1, (B) Resistance is due to mutation in codon 50 isoleucine to valine substitution, (C) Decrease cholesterol and triglyceride levels, (D) Combination with ritonavir do not have any advantage
Answer is B. Atazanavir is effective against both against HIV 1 and HIV 2 but NNI are effective only against HIV 1. They do not decrease cholesterol and triglyceride levels. Combination with ritonavir have an advantage due to the phenomenon of Ritonavir boosting. The resistance is due to mutation in codon 50 isoleucine to valine substitution.