Hypercalcemia in the setting of squamous cell carcinoma esophagus is mainly due to:: (A) Bone metastasis, (B) Calcitonin excess, (C) Parathormone excess, (D) Parathormone related peptide secretion
Answer is D. Hypercalcemia may occur in the absence of osseous metastases in squamous cell carcinoma esophagus, probably from parathormone-related peptide secreted by tumor cells. Ref:Harrison,E-18,P-765