MRP 2 and conjugated hyperbilirubinemia associated with which of the following?: (A) Criggler Najjar syndrome type I, (B) Criggler Najjar syndrome type II, (C) Dubin Johnson syndrome, (D) Rotor syndrome
Answer is C. Dubin-Johnson Syndrome:- Defect in canalicular protein called MRP2 leading to increase in conjugated bilirubin (CB). Criggler Najjar Syndrome type I and type II has decrease activity of UDP-glucuronodyltransferases leading to increase unconjugated bilirubin (UCB) which enters CNS and can cause kernicterus.