LEVOSIMENDAN acts on the all the following mechanism except ?: (A) phosphodiesterase inhibitor 3, (B) neprilysin inhibitor, (C) potassium channel opener, (D) sensitizes myocardium to calcium channels
Answer is B. Molecular Targets Pharmacological Effects * Calcium sensitisation of the contractile * inotropy without increase of calcium transient and oxygen consumption apparatus by selective binding to calcium * Anti-stunning effect saturated cardiac troponin C * Opening of the ATP-sensitive potassium * Vasodilation (including coronary aeries) channels on the smooth muscle of the vasculature * increase of end-organ perfusion * Opening of the mitochondrial ATP- .Cardioprotection and organ protection Anti-ischaemic effect * sensitive potassium channels REF : KD TRIPATHI 8TH ED