Ursodeoxycholic acid is a: (A) Urinary Stone dissolving drug, (B) Thrombolytic drug, (C) Gallstone dissolving drug, (D) Antifibrinolytic
Answer is C. Medical therapy of Gallstones Medical therapy of gallstones utilize bile acids : Chenodeoxycholic acid(CDCA) and Ursodeoxycholic acid(UDCA) Mechanism of Action : They inhibit HMG-CoA reductase, rate limiting enzyme for cholesterol synthesis, thus decreasing cholesterol saturation of bile They cause disruption of cholesterol from the stones by physicochemical means Ref: Sabiston 20th edition Pgno : 1494