Fluconazole differs from ketoconazole in the following aspect: (A) It is not active by the oral route, (B) It is a more potent inhibitor of drug metabolism, (C) It is not effective in cryptococcal meningitis, (D) It is unlikely to produce anti-androgenic side effects
Answer is D. Fluconazole is a preferred agent because it has

Very good oral absorption.
Maximum CNS penetration. (therefore effective in cryptococcal meningitis).
No inhibitory action on microsomal enzymes.
No anti-androgenic property.