All statement about Plummer Winson Syndrome are true except -: (A) Commonly leads to carcinoma in lower third of esophagus, (B) Common with iron deficiency, (C) Common in females, (D) Premalignant
Answer is A. Ans. is 'a' i.e., Commonly leads to carcinoma in lower third of esophagusPlummer-Vinson syndromeo Plummer-Vinson syndrome, also known as Brown-Kelly-Paterson syndrome or sederopenic dysphagia, seen in middle aged edentulous women.o The plummer Vinsion Paterson Brown Kelly Syndrome is characterized by: -DysphagiaChronic iron deficiency anemiaAtrophic oral mucosa and glossitisBrittle, spoon-shaped fingernails (Koilonychia)o The cause of dysphagia is usually a cervical esophageal web, but abnormal pharyngeal and esophageal motility may play a role.o The syndrome eharactersticallv occurs in middle aged edentulous (without teeth) women,o It is a premalignant lesion. Approximately 10% of patient develop squamous cell Ca of esophagus, oral cavity or the hypopharynx.o As iron-deficiency anemia is a common finding, it is also known as sideropenic dysphagia.o Carcinoma develops in post-cricoid region (not in lower third esophagus).