In Non competitive inhibition of enzyme:: (A) Decreased Km, increase Vmax, (B) Increase Km, Increase Vmax, (C) Normal Km, decrease Vmax, (D) Normal Km, increase Vmax
Answer is C. Ans. (c) Normal Km, decrease VmaxRef: Harper's Biochemistry, 30th edn. pg. 81-82Type of InhibitionKmVmaxCompetitive inhibitionINCREASEDSAMENon- Competitive inhibitionSameDECREASEDCompetitive Inhibition: Substrate and inhibitor Both compete for same site on enzyme.Non-Competitive Inhibition: Substrate and Inhibitor both bind at different site in the enzyme.