A girl with acute promyelocytic leukemia was admitted for management. While on treatment she developed tachypnea, fever and pulmonary infiltrates. What should be done for the treatment of this problem?: (A) Dexamethasone, (B) Cytarabine, (C) Doxorubicin, (D) Methotrexate
Answer is A. Ans. (A) Dexamethasone(Ref: Harrison 19/e p1686-87)The features given are known as APL differentiation syndrome which can occur while treatment with tretinoin. The treatment is with steroids.