Which of the following statement regarding first order kinetics is true?: (A) It is independent of plasma concentration, (B) Tl/2 of the drug increases with dose, (C) Clearance of the drug decreases with dose, (D) A constant propoion of plasma concentration is eliminated
Answer is D. According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8