Principal serum enzyme used in clinical diagnosis of Wilson disease: (A) Aspaate aminotransferase, (B) Ceruloplasmin, (C) b-Glucoscerebrosidase, (D) Lactate dehydrogenase isozyme 5
Answer is B. Serum enzymeDiseaseAspaate aminotransferase(AST, or SGOT)Myocardial infarctionAlanine aminotransferase(ALT, or SGPT)Viral hepatitisAmylaseAcute pancreatitisCeruloplasminHepatolenticular degeneration(Wilson disease)Creatine kinaseMuscle disorders and myocardialinfarctiong-Glutamyl transferaseVarious liver diseasesLactate dehydrogenaseisozyme 5Liver diseasesLipaseAcute pancreatitisb-GlucoscerebrosidaseGaucher diseasePhosphatase, alkaline(isozymes)Various bone disorders,obstructive liver diseasesRef: Harper&;s Biochemistry; 30th edition; Chapter 7 Enzymes: Mechanism of Action