A highly ionized drug: (A) Is excreted mainly by kidney, (B) Can carry placental barrier easily, (C) Is well absorbed from intestine, (D) Accumulates in cellular lipids
Answer is A. Ionized molecules cannot cross the biological membranes .therfore they are less likely to be absorbed . Entry of the molecules through blood brain barrier and blood placental barrier is also restricted .these drugs cannot be reabsorbed in the nephron,thus are excreted by the kidney . Refer kDT 7/e p29