Which of the following disease modifying anti- rheumatoid drugs is a prodrug?: (A) Etanercept, (B) Nimesulide, (C) Sulfasalazine, (D) Colchicine
Answer is C. - Sulfasalazine is a pro-drug. - It dissociates in the colon to produce 5-ASA (MESELAMINE) and sulfapyridine. - 5-ASA is the active moiety in treatment of ulcerative colitis whereas sulfapyridine is used to treat rheumatoid ahritis.