Perforins are produced by:: (A) Cytotoxic T cells, (B) Suppressor T cells, (C) Memory helper T cells, (D) Plasma cells
Answer is A. Perforins are hole forming proteins synthesized by cytotoxic T-cells. They can perforate the plasma membrane of the target cells that are under attack by CD8+ lymphocytes. Granzymes are delivered into the target cells through these holes formed by perforins. In addition, the perforin pores allow water to enter the cells, thus causing osmotic lysis.