Ursodeoxycholic acid is a :: (A) Urinary stone dissolving drug, (B) Thrombolytic drug, (C) Gall stone dissolving drug, (D) Antifibrinolytic
Answer is C. • Medical therapy for gallstones utilizes bile acids: Chenodeoxycholic acid (CDCA) and Ursodeoxycholic acid (UDCA)
Mechanism of Action
• They inhibit HMG-CoA reductase, the rate limiting enzyme for cholesterol synthesis, thus decreases cholesterol saturation of bile
• They cause dispersion of the cholesterol from the stones by physico-chemical means