Which of the following antimicrobial is effective against an organism producing extended spectrum beta lactamase?: (A) Amoxicillin-Clavulinic acid, (B) Cefepime, (C) Piperacillin-Tazobactam, (D) Ceftriaxone
Answer is C. Ans. (C) Piperacillin-tazobactam(Ref: Harrison 18th/1247)Organisms producing ESBL-like Klebsiella are resistant to most beta-lactams except carbapenems.ESBL can be inhibited by beta lactamase inhibitors.Amoxicillin is not effective against Klebsiella whereas piperacillin has wide spectrum including Klesiella.