In organophosphorus compound poisoning, organophosphorus compound actions are -: (A) Phosphorylates enzyme, (B) Irreversibly inhibit cholinesterase, (C) Oximes effective when given beyond 24 hours, (D) Atropine can't reverse in early stage
Answer is A. Mechanism of Action Organophosphorus compounds are inhibitors of acetylcholinesterase by phosphorylating the enzyme. Acetyl cholinesterase is required to hydrolyse acetylcholine to choline and acetic acid As a result, there is accumulation of acetylcholine with continued stimulation of local receptors and eventual paralysis of nerve or muscle . Organophosphate intoxication leads to characteristic end-plate abnormalities that reflect the degree of AchE inhibition and increase in Ach concentration at the neuromuscular junction. REF;THE SYNOPSIS OF FORENSIC MEDICINE:KS NARAYANA REDDY;28th EDITION;PAGE NO 291