Which of the following diuretics decreases the renal lithium clearance?: (A) Acetazolamide, (B) Mannitol, (C) Furosemide, (D) Spironolactone
Answer is C. Ref: KDT 8TH ED. Loop diuretics and thiazides cause NA+ loss in the nephron, this leads to compensatory increase in reabsorption of Na+ and Li+ in the proximal tubules.