Lower esophageal sphincter tone is due to: (A) Vasoactive intestinal peptide, (B) Nitrous oxide, (C) Acetylcholine, (D) Pancreatic polypeptide
Answer is C. Ans. (c) AcetylcholineRef: Bailey & Love 26th ed. / 988There are two types of control of LES via the Myenteric plexus:* Excitatory (cholinergic) ganglionic neurons* Inhibitory (nitric oxide) ganglionic neuronsFunctionally, inhibitory neurons mediate Deglutitive lower esophageal sphincter (LES) relaxation and the sequential propagation of peristalsis.