Which of the following cephalosporins does not need dose modifications even in presence of decreased GFR-: (A) Cefipine, (B) Cefoperazone, (C) Cefotaxim, (D) Cefuroxine
Answer is B. Ans. is 'b' i.e., Cefoperazone o Cefoperazone is primarily exreted in bile in contrast to other cephalosporins that are usually excreted by the kidney --> safe in renal failure. o Cephalosporins that can be used in presence of renal failure :- i) Cefoperozone, ii) Ceftriaxone, iii) Cefoperamide