The subtype of Hodgkin's disease, which is histogentically distinct from all the other subtypes, is -: (A) Lymphocyte predominant, (B) Nodular sclerosis, (C) Mixed cellularity, (D) Lymphocyte depleted
Answer is A. Ans is 'a' i.e., Lymphocyte predominance Hodgkins lymphoma can be divided into two groups. Classical hodgkin lymphoma o This group includes (i) Nodular sclerosis (iii) Lymphocyte-rich (ii) Mixed cellularity (iv) Lymphocyte-depletion o The Reed-sternberg cells have similar immunophenotype, i.e., express CD 15 and CD 30. 2. Lymphocytic predominance Hodgkin lymphoma o The Reedsternberg cells express CD 20 marker, characteristic B-cell immunotype.