Which of the following inhibits transcription ?: (A) Cyclosporine, (B) Rapamycin, (C) 5-Flurouracil, (D) Cyclophosphamide
Answer is A. Ans. is 'a' i.e., Cyclosporine Cyclosporine inhibits transcription by binding to a protein called cyclophilin. This complex then inactivates calcineurin. (Calcineurin is a protein which is responsible for the transcription of cytokine gene)