The subtype of Hodgkin's disease, which is histogenetically distinct from all the other subtypes, is -: (A) Lymphocyte predominant, (B) Nodular sclerosis, (C) Mixed cellularity, (D) Lymphocyte depleted
Answer is A. Hodgkin's lymphoma can be divided into two groups.

1. Classical Hodgkin lymphoma

This group includes


Nodular sclerosis  (iii) Lymphocyte-rich
Mixed cellularity    (iv) Lymphocyte-depletion


The Reed-Sternberg cells have similar immunophenotype, i.e., express CD 15 and CD 30.

2. Lymphocytic predominance Hodgkin lymphoma

The Reed sternberg cells express CD 20 marker, characteristic B-cell immunotype.