All are true about Prolactin agonist EXCEPT:: (A) Associated with lactation, (B) Stimulate milk production after child birth, (C) Dopamine stimulate prolactin production, (D) Dopamine inhibit prolactin production
Answer is C. Ans. (c) Dopamine stimulate prolactin productionRef. KDT 6th ed. / 235-236* Prolactin is produced from anterior pituitary and is associated with lactation.* Prolactin is under predominant inhibitory control of hypothalamus through PRIH (Prolactin Release Inhibitory Hormone), which is Dopamine that acts on pituitary lactotrope D2 receptor.* Dopaminergic agonist like bromocriptine, DA, cabergoline decrease plasma prolactin levels and is used to treat hyperprolactinemia* Dopaminergic antagonists like chlorpromazine haloperidol, metoclopramide causes hyperprolactinemia by blocking D2 receptors.* A progressive increase in prolactin occurs during pregnancy, peaking at term. After childbirth, this dopamine is inhibited and prolactin now stimulates milk production.Also Know* Milk production is stimulated by: Prolactin (remember production by prolactin).* Milk secretion is stimulated by: Oxytocin* DOC for hyperprolactinemia: Bromocriptine