Autosplenectomy is seen in:: (A) Hereditary spherocytosis, (B) Sickle cell disease, (C) Thalassaemia, (D) Autoimmune anemia
Answer is B. - In sickle cell anemia initially, congestive splenomegaly is seen. - Later, sickled RBC causes aerial occlusion - ischemic damage to spleen - resulting in Fibrosis of spleen / autosplenectomy.