All of the following are true about nodular sclerosis of Hodgkin's disease except -: (A) Well formed fibrous stands, (B) CD 15 +, (C) CD 20 +, (D) Infiltration by plasma cells
Answer is C. CD 20 is positive in lymphocytic predominance variant (not in nodular sclerosis variant)

 Pathology of nodular sclerosing variant

Presence of lacunar variant of Reed-sternberg cells.
Deposition of collagen in bands that divide the involved lymph nodes into circumscribed nodules.
Fibrosis may be scant or abundant.
The Reed-Sternberg cells are found in a polymorphous background of T-cells, eosinophils, plasma cells and macrophages.

Following information has been added in 8th  of Robbins

Classical Reed-Sternberg cells are also positive for PAX5 (a B-cell transcription factor) along with CD15 and CD30.