Which of the following condition causes hyperuricemia due to both increased production and decreased excretion?: (A) PRPP Synthetase over activity, (B) Glucose-6-phosphatase Deficiency, (C) HGP deficiency, (D) Renal failure
Answer is B. Von Gierke disease cause hyperuricemia by both ways: Overproduction: Glucose 6 phosphatase deficiency leads to diversion of glucose-6-phosphate to HMP shunt -| ribose-5-phosphate -|PRPP - nucleotide synthesis - |Uric Acid. Underexcretion: Accumulated lactic acid competes with uric acid for renal excretion.