Which of the following is not seen on hemoglobin electrophoresis in sickle cell anemia: (A) HbA, (B) HbA2, (C) HbF, (D) HbS
Answer is A. Ref Harrison 19 th ed pg 634 sickle cell syndromes are caused by a mutation in the b-globin gene that changes the sixth amino acid from glutamic acid to valine. HbS (a2 b2 6 Glu-Val) polymerizes reversibly when deoxygenated . No beta chains and therfther no HbA