Investigation of choice in hirschsprug's disease is -: (A) Rectal manometry, (B) Rectal examination, (C) Rectal biopsy, (D) Ba enema
Answer is C. Definitive diagnosis is made by rectal biopsy. The histopathology of Hirschprung's disease is the absence of ganglion cells in the nerve plexus, presence of hypertrophied nerve bundles and increased acetykholinesterase-positive nerve fibres.