Liver biopsy of an icteric patient shows intensely eosinophilic objects called as Councilman bodies. What can be the diagnosis of this patient?: (A) Hea failure, (B) Acute viral hepatitis, (C) Cirrhosis of liver, (D) Wilson's disease
Answer is B. Councilman bodies (acidophil or apoptotic body) are individual hepatocyte necrosis, in which a dead hepatocyte is identifiable as a shrunken, intensely eosinophilic, round body with no or a pyknotic nucleus. They lie free in the sinusoid. They found in the liver of individuals suffering from viral hepatitis, yellow fever, or other viral syndrome. Ref: The Washington Manual of Surgical Pathology: Depament of Pathology and ... By Peter A. Humphrey, Louis P. Dehner, John D. Pfeifer, 2008, Page 209 ; Biopsy Interpretation of the Liver by Stephen A. Geller, Lydia M. Petrovic, Page 90