Which of the followign drugs require dose adjustment in renal failure?: (A) Cefoperazone, (B) Doxycycline, (C) Streptomycin, (D) Rifampicin
Answer is C. Ans. (C) Streptomycin(Ref: Katzung 10/e p835 KDT 8/e p746)Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas doxycycline, rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure.