Which among the following is the most common tumor associated with neurofibromatosis in a child?: (A) Juvenile myelomonocytic leukemia, (B) Acute lymphoblastic leukemia, (C) Acute monocytic leukemia, (D) Acute myeloid leukemia
Answer is A. Patients with neurofibromatosis type 1 and Noonan syndrome have a predilection for JMML, since they have germline mutations involved in RAS signaling. AML and ALL are associated with DOWN syndrome.