Which of the following is not seen in MEN1?: (A) Posterior pituitary tumors, (B) Foregut carcinoids, (C) Parathyroid hyperplasia, (D) Pancreatic neuroendocrine tumors
Answer is A. Features of Multiple Endocrine Neoplasia (11q l3)/Intron 4 ss : Parathyroid adenoma (90%)- Most common presentation. Entero-pancreatic tumours- Most common is gastrinoma and least common is V.I.Poma in MEN1. Pituitary adenoma- most common is Prolactinoma and least common is non-functioning adenoma in MEN1. Associated tumours. Adrenal coical tumour. Neuroendocrine tumours- thymus, lungs (Foregut derivatives include bronchus and thymus and hence choice B is correct). Lipoma Angiofibroma -Most common skin manifestation in MEN 1 (Angiofibroma>collagenoma) Brain tumour -meningioma Pheochromocytoma (<1%)