Which drug is used for treatment of pulmonary hypertension -: (A) Calcium channel blockers, (B) Todafil, (C) Bosentan, (D) All of the above
Answer is D. Ans. is 'd' i.e., All of the aboveo Drugs used to treat pulmonary hypertension are act by -1) Direct vasodilators# Calcium channel blockers are the first line therapy if patient responds to vasodilators.2) Increasing effect of NO/cGMP# Phosphodiesterase-5 inhibitors prevent degradation of cGMP and cause vasodilatation.# Drugs are sildenafil and todafil.3) By increasing effect of prostacycline (PGI2)# PGI2 causes pulmonary vasodilatation.# So prostacyclins like epoprostenol, treprostinal, iloprost or beraprost can be used in pulmonary hypertension.4) Decreasing effect of endothelin# Endothelin causes pulmonary vasoconstriction.# Endothelin receptor blockers (endothelin antagonists) are used in pulmonary hypertension.# These are Bosentan and ambrisentan.