Which of the following drug is responsible for extrapyramidal side effects?: (A) Metoclopramide, (B) Cisapride, (C) Domperidone, (D) All of the above
Answer is A. Ans. A. MetoclopramideMetoclopramide and domperidone both block the D2 receptor. Metoclopramide can cross the BBB whereas domperidone do not cross. So extrapyramidal side effects are seen with Metoclopramide.