Cisatracurium, pure CIS isomer of atracurium all true except:-: (A) Is metabolized primarily by Hoffman degradation, (B) Is cardiovascular stable, (C) Produces more laudanosine than an equipotent dose of atracurium, (D) Has onset & duration similar to atracurium
Answer is C. Atracurium molecule is mixture of 10 stereoisomers in which Cis isomer is only 15 %. A total Cis isomer was seperated and new drug was prepared which is Cisatracurium. Cisatracurium a pure CIS isomer of atracurium produces no /minimal histamine release and is more potent than atracurium. Thus it is given in less dose and causes less by product laudanosine production at equipotent dose.