The gold standard for diagnosis of gastroesophageal reflux disease (GERD) is: (A) Endoscopy, (B) Barium swallow, (C) Esophageal manometry, (D) 24-hours ambulatory pH monitoring
Answer is D. The most sensitive test for diagnosis of GERD is 24-h ambulatory pH monitoringRef: Harrison; 19th edition; Page no: 1894