Which drug is not acetylated ?: (A) INH, (B) Dapsone, (C) Hydralazine, (D) Metoclopropamide
Answer is D. Metoclopromide Acetylation is a phase II metabolic reaction Phase II reactions serves to attach a conjugate to the drug molecule. After the phase II reactions all drugs becomes water soluble, so that they can be readily eliminated from the body. Phase II reactions includes - Glucuronidation - Acetylation - Methylation - Sulfation - Glycine conjugation Acetylation Drugs having amino or hydrazine resides are conjugated with the help of acetyl coenzyme A. Examples are : S - Sulfonamides (Dapsone) H- Hydralazine I - Isoniazid P - PAS Acetylation is a genetically mediated condition. Multiple genes control the acetyl transferases and the rate of acetylation shows genetic polymorphism