True statement regarding development of drug resistance in MRSA is?: (A) Results due to penicillinase enzyme production, (B) Occurs due to change in penicillin blinding proteins, (C) Chromosome mediated, (D) Treated with amoxicillin + clavulanic acid
Answer is B. MRSA have emerged in many areas. These are insensitive to all penicillinase-resistant penicillins and to other beta-lactams as well as to erythromycin, aminoglycosides, tetracyclines, etc. The MRSA have altered PBPs which do not bind penicillins. ESSENTIALS OF MEFICAL PHARMACOLOGY page no 721