All of the following conditions have autosomal dominant inheritance except -: (A) Fabry disease, (B) Marfan's syndrome, (C) Osteogenesis imperfecta, (D) Ehlers Danlos syndrome
Answer is A. Ans. is 'a' i.e., Fabry's disease Autosomal dominant disorders o Normally a gene pair has two alleles. o When one allele becomes abnormal due to mutation it is called heterozygous state. o When both the alleles become abnormal due to mutation it is called homozygous state. o Autosomal dominant disorders are manifested in heterozygous state, i.e. only if one allel is abnormal the disease will be manifested.