Imatinib is useful in treatment of ?: (A) Neuro fibromatosis, (B) CD 117 positive GIST, (C) Neuroendocrine tumor of pancreas, (D) Breast Ca
Answer is B. Ans. is 'b' i.e., CD 117 positive GIST GIST cells are positive for CD-1I7 (C-KIT). o Mutation in C-KIT results in continuous activation of receptor tyrosine kinase. o Imatinib inhibits tyrosine kinase activity of C-KIT --> Imatinib is used in GIST o Patients who develop resistance to imatinib may respond to the multiple tyrosinase kinase inhibitor sunitinib.