Following statements regarding ulcerative colitis is true- (: (A) Smoking has a protective effect, (B) Smoking does not have a protective effect, (C) There is no relation to smoking, (D) Smoking causes relapses
Answer is A. Ulcerative colitis Inflammation invariably involves the rectum (proctitis) and spreads and also has some bleeding and proximally in a continuous manner to involve the entire colon in some cases (pancolitis). In long-standing pancolitis, the bowel can become shoened and post-inflammatory 'pseudopolyps' develop; these are normal or hyperophied residual mucosa within areas of atrophy . The inflammatory process is limited to the mucosa and spares the deeper layers of the bowel wall . Both acute and chronic inflammatory cells infiltrate the lamina propria and the crypts ('cryptitis'). Crypt abscesses are typical. Goblet cells lose their mucus Ref Davidson edition23rd pg 815