Which of the following is not a major criteria for diagnosis of multiple myeloma?: (A) Lytic bone lesions, (B) Plasmacytoma on tissue biopsy, (C) Bone marrow plasmacytosis > 30%, (D) M' spike > 3g% for Ig G, > 2g% for IgA
Answer is A. "Lytic bone lesions" is not a major criteria for the diagnosis of multiple myeloma. It is a minor criteria for the diagnosis of multiple myeloma. So "Lytic bone lesions" is the single best answer of choice. Ref: The Washingtom Manual of Surgical Pathology: Depament of Pathology By Peter A Humphrey, Loius P.Dehner, Ohn D. Pfeifer, Page 565.