How does hyperammonemia inhibit TCA cycle: (A) By depleting Alpha Ketoglutarate, (B) By depleting Oxaloautate, (C) By increasing concentration of alpha ketoglutarate, (D) By increasing concentration of oxaloautate.
Answer is A. Build up of cummonemia which occurs in area cycle disorders or advanced liver disease inhibits TCA cycle by depleting Alpha ketoglutarate.