A hypeensive patient on medication with beta blocker develops severe bradycardia on taking medicines. Which of the following is least likely to be the responsible agent?: (A) Metoprolol, (B) Nadolol, (C) Pindolol, (D) Atenolol
Answer is C. Pindolol has intrinsic sympathomimetic acitivity and therefore has lesser risk of causing bradycardia Beta-Blockers with Intrinsic Sympathomimetic Activity (ISA) Preferred in the patients prone to develop severe bradycardia with b blocker therapy. However, these drugs are less useful in angina (because of stimulation of hea by b1 receptors). The drugs can be remembered as * COntain - Celiprolol, Oxprenolol * Paial - Pindolol, Penbutolol * Agonistic - Alprenolol * Activity -Acebutolol