Mechanism of action of triazoles is:: (A) Inhibit ergosterol synthesis, (B) Inhibit mitotic spindle, (C) Create pores in the membrane, (D) Inhibit beta 1,3 glycan
Answer is A. Ans. (A) Inhibit ergosterol synthesis(Ref: Goodman and Gilman 13th/e p1091)Anti-fungal drug groupExampleMechanismPolyeneAmphotericin BCreate artificial pores in membrane by binding to ergosterolAzoles (Imidazole and triazoles)FluconazoleItraconazoleInhibit Lanosterol-14- alpha-demethylaseAllylaminesTerbinafineButenafineInhibit squalene epoxidaseAnti-metabolite5-FlucytosineInhibit DNA formationBenzofuranGriseofulvinBinds to tubulin and inhibit mitosisEchinocandinsCaspofungin MicafunginInhibit beta 1,3 glycan in fungal cell wall