N-MYC amplification is ssociated with which tumor?: (A) Burkitt lymphoma, (B) Squamous cell carcinoma lung, (C) Astrocytoma, (D) Neuroblastoma
Answer is D. Reference :Robbins basic pathology 9th edition pg no 189:The most interesting cases of ampli cation involve NMYC in neuroblastoma and ERBB2 in breast cancers. NMYC is ampli ed in 25% to 30% of neu roblastomas, and the ampli cation is associated with poor prognosis