The most specific antibody for Rheumatoid ahritis is?: (A) Antinuclear antibody (ANA), (B) Rheumatoid factor, (C) Anti-cyclic citrullinated peptide (anti-CCP) antibody, (D) Anti-double stranded DNA antibody
Answer is C. Anti-CCP is the most specific antibody for rheumatoid ahritis with specificity of 95%. 20% patients have elevated ANA and ESR. CRP levels are elevated propoional to disease activity.