Pentosuria is due to defect in which pathway?: (A) Glycolysis, (B) Polyol pathway, (C) Uronic acid pathway, (D) Kreb's cycel
Answer is C. Essential Pentosuria i. It is one of the members of the Garrod&;s tetrad. The incidence is 1 in 2,500 bihs. ii.It is an inborn error of metabolism, due to defect in glucuronic acid pathway of glucose. In the pathway, L-xylulose is conveed to D-xylulose by two enzymes, xylitol dehydrogenase and xylulose reductase absence of any of this enzyme lead to pentosuria.Ref: DM Vasudevan, 7th edition, page no: 134