Hereditary chronic pancreatitis is caused by mutation of: (A) Cationic trypsinogen or PRSS1, (B) CFTR, (C) PTSI, (D) SPINK1
Answer is A. Hereditary pancreatitis Autosomal dominant disease Due to a missence mutation on cationic trypsinogen, or PRSS1(Protease, serine 1) results in premature, intrapancreatic activation of trypsinogen The incidence is equal in both sexes Ref: Sabiston 20th edition Pgno :1532