Which of the following statements about fluconazole is most accurate?: (A) It is highly effective in the treatment of aspergillosis, (B) It does not penetrate the blood-brain barrier, (C) Its oral bioavailability is less than that of ketoconazole, (D) It inhibits demethylation of lanosterol
Answer is D. * Fluconazole (Azoles) act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. * It has very good CNS penetration and oral bioavailability. * It is not very effective against aspergillosis (voriconazole is the drug of choice).