Which of the following group of antifungal drugs acts through squalene epoxidase enzyme?: (A) Imidazole and triazole, (B) Griseofulvin, (C) Polyenes, (D) Allylamine and benzylamine
Answer is D. Ans. D. Allylamine and benzylaminea. Allylamines and benzylaminesb. (terbinafine, butenafine)c. inhibit squalene epoxidase, an early step of ergosterol biosynthesisd. Azolese. Inhibits lanosterol - 14a, demethylase - depletes ergosterol and accumulates aberrant and toxic sterol in the membrane