Which of the following is a new drug that acts by inhibiting PCSK9?: (A) Reslizumab, (B) Brodalumab, (C) Alirocumab, (D) Ixekizumab
Answer is C. Monoclonal Antibodies that target PCSK9: Alirocumab and Evolocumab. Pro protein convease subtilisin Kexan type 9 (PCSK9) is a protein that binds LDL receptors and transpo them to lysosomes where these are degraded . Therefore instead of recycling of LDL receptor to surface of hepatocytes they get destroyed. Inhibitors of PCSK9 therefore prevent destruction of LDL receptor resulting in lowering of LDL cholesterol.