In a pregnant woman, all can be given for SLE, EXCEPT:: (A) Methotrexate, (B) Sulfasalazine, (C) Hydroxychloroquine, (D) Prednisone
Answer is A. Methotrexate Category X drug (FDA), highly Teratogenic. Should avoid during pregnancy, if there is a risk of becoming pregnant, or if they are breastfeeding. Can be toxic to the embryo and can cause fetal defects and spontaneous aboion. Females should discontinue use for at least 1 ovulatory cycle before conception and the male patients should stop taking methotrexate at least 3 months prior to a planned conception.