Which of the following is calculated as the ratio of the area under the curve (AUC) obtained by oral administration vs. the AUC for intravenous administration of the same drug?: (A) Absorption, (B) Bioavailability, (C) Clearance, (D) Elimina on rate constant
Answer is B. bioavailabilitygenerally refers to the fraction of drug absorbed systemically, and is thus available to produce a biological effect. This is often measured by quantifying the "AUC". In order to determine the respective AUCs, the serum concentration vs. time plots are typically gathered using C-14 labeled drugs and AMS (accelerated mass spectroscopy). Ref k d tripati 6/e p27