A 5 year old boy has recurrent infections. low platelet count and rash as shown below. What is the likely diagnosis?: (A) Severe Combined Immunodeficiency, (B) Job Syndrome, (C) Bruton's Agammaglobulinemia, (D) Wiskott Aldrich Syndrome
Answer is D. The above clinical picture is suggestive of Wiskott aldrich syndrome Wiskott aldrich syndrome - X-linked disorder Defect in WASP gene (Chromosome X p 11) Clinical features -Triad of Eczema Recurrent infections Thrombocytopenia with small platelets Diagnosis - Platelets - small and decreased in number IgM - low IgE and IgA - Elevated