A young woman who has suffered recurrent aboions, presents with thrombosis of leg veins. The most likely diagnosis is: (A) Chromosomal abnormality, (B) Factor VIII deficiency, (C) Antiphospholipid antibody syndrome, (D) Increased antithrombin III levels
Answer is C. Anti phospholipid syndrome - Vascular thrombosis Recurrent pregnancy loss >=3 spontaneous aboions <10 weeks Death of normal fetus > 10 weeks Premature bih at <34 weeks due to pre-eclampsia or placental insufficiency Laboratory Features:1. Elevated anticardiolipin antibodies (IgG or IgM)2. Elevated Anti beta-2 glycoprotein -1 Antibody3. Presence of Lupus Anticoagulant (LA) in plasma