Which of the following antiglaucoma medications are not safe in infants: (A) Timolol, (B) brimonidine, (C) Latanoprost, (D) Dorzolamide
Answer is B. Apraclonidine and brimonidine can cross blood brain barrier and can cause CNS depression and Apnea in neonates. therefore these are contraindicated in children less than 2 years of age Refer Goodman and Gilman 12e p1788,kdt 6/e 168