Gemfibrozil is:-: (A) HMG CoA inhibitor, (B) PPAR-a activator, (C) Inhibit cholesterol synthesis, (D) Inhibit cholesterol absorption
Answer is B. Gemfibrozil: MOA: Activation of the nuclear transcription receptor "peroxisome proliferator - activated receptor alpha" (PPAR-a). Major effects are to increase plasma HDL and to decrease plasma TG. Myopathy risk highest when used with statins Statins: Inhibit HMG COA reductase Inhibit cholesterol synthesis. EZETIMIBE- Inhibit intestinal cholesterol absorption.