Retinoblastoma –: (A) Is inherited in 50% of cases, (B) Is caused by deletion of 11q14, (C) Rosettes suggest good prognosis, (D) Causes death in 60% of sufferers in the UK
Answer is C. Rosettes are feature of well differentiated retinoblastoma, therefore suggest the good prognosis.
Hereditary retinoblastoma accounts for 40% of cases and the gene is located at 13q14 chromosome.
Prognosis is fair with 70-85% survival rate if the eyeball is enucleated before the occurrence of extra ocular extension.