Reason for preferring cis-Atracurium over Atracurium is:-: (A) Faster acting than Atracurium, (B) Lesser provocation of histamine release, (C) Shoer action than atracurium, (D) Does not undergo Hoffman elimination
Answer is B. Cis-atracurium and Atracurium both are NMJ blocking agent. Cis atracurium has same pharmacokinetic propeies as atracurium. Atracurium release histamine and is metabolized to Laudonasine, which can provoke seizures. Both undergo Hoffman elimination.