<img alt="" src=" />MIC-2 is a marker of: (A) Ewing's sarcoma, (B) Osteosarcoma, (C) Dermatofibrous protruberns, (D) Alveolar cell sarcoma
Answer is A. Study repos on the specific expression of the MIC2 gene, a pseudoautosomal gene located on the sho arms of the X and Y chromosomes, on Ewing&;s sarcoma (ES) and peripheral primitive neuroectodermal tumor (pPNET) cells. The gene product, a cell membrane protein, is recognized by the newly established monoclonal antibody (MoAb) HBA-71 and the previously described MoAb 12E7 and RFB-1. Fuhermore, the reaction pattern of the MIC2 antibodies, especially HBA-71, with normal tissues and a great number of benign and malignant tumors (70 different tumors, 199 tumor samples), as well as the correlation between the specific chromosomal aberrations.