Absolute contraindication of HRT is?: (A) Endometriosis, (B) Osteoarthritis, (C) Heart disease, (D) Breast carcinoma
Answer is D. ANSWER: (D) Breast cancerREF: Harrisons 18th ed edition chapter 348Contraindications to HT should be assessed routinely and include unexplained vaginal bleeding, active liver disease, venous thromboembolism, history of endometrial cancer (except stage 1 without deep invasion) or breast cancer, and history of EURHD, stroke, transient ischemic attack, or diabetes.Relative contraindications include hypertriglyceridemia (>400 mg/dl) and active gallbladder disease; in such cases, transdermal estrogen may be an option