Alpha-methyldopa is primarily used for: (A) Pregnancy induced hypeension, (B) Renovascular hypeension, (C) First line agent in hypeension, (D) Refractory hypeension
Answer is A. They act on central alpha 2a receptors to decrease efferent sympathetic activity. It decreases t.p.r more than H.R or C.O It is infrequently used now. (Ref: Essentials of medical pharmacology, K.D Tripathi, 7th edition, page 566)