All are TRUE about amyloidosis, EXCEPT:: (A) It is an extracellular deposit, (B) Insoluble polymeric protein fibrils, (C) Amyloid fibrils share a common pleated structure, (D) The term amyloid was coined by Lister
Answer is D. Amyloidosis is the extracellular deposition of insoluble polymeric protein fibrils. This disorder is due to misfolding of proteins. Eg: Alzheimer's disease and other neurodegenerative diseases, Transmissible prion diseases, Ceain of the cystic fibrosis mutations. Amyloid fibrils share a common beta-pleated sheet structural conformation. It has unique staining propeies. The term amyloid was coined by Rudolf Virchow. Ref: Harrison, Edition-18, Page 942