Hepatitis with cholestatic jaundice occurs most frequently as an adverse reaction to the following preparation of erythromycin:: (A) Erythromycin base, (B) Erythromycin stearate, (C) Erythromycin estolate, (D) Erythromycin ethyl succinate
Answer is C. Erythromycin estolate is responsible for cholestatic jaundice. It stas after 2-3 weeks of staing treatment. Symptoms include nausea, vomiting and cramping pain in abdomen. Risk of this adverse effect increases significantly in pregnancy. Therefore, erythromycin estolate is contra-indicated in pregnancy.