What factor is responsible for deciding whether an antibody will remain membrane bound or get secreted?: (A) RNA splicing, (B) Class switching, (C) Differential RNA regulation, (D) Allelic exclusion
Answer is C. Synthesis and diversity of immunoglobulin in membrane bound or secretory form is determined by differential/ alternative RNA processing of heavy, kappa & lambda light chains & immunoglobulin gene rearrangements.