A patient receives a toxic dose of lignocaine i.v., the patient is likely to exhibit?: (A) Excessive salivation, (B) Mydriasis and diarrhea, (C) Respiratory paralysis, (D) Seizures and coma
Answer is D. * If LA reaches the blood stream, most prominent adverse effects are related to CNS and CVS. * In CNS :-stimulation (convulsions) followed by depression (coma) is seen. - Initial stimulation is due to inhibition of the inhibitory neurons.