An asthmatic patient is on theophylline suddenly developed infection, which of the following antibiotic should not be given to prevent side effects of theophylline?: (A) Ampicillin, (B) Erythromycin, (C) Cephalexin, (D) Sparfloxacin
Answer is B. Erythromycin potentiates the effects of the following drugs by interfering with CYP-mediated metabolism of these drugs. Carbamazepine Coicosteroids Cyclosporine Digoxin Ergot alkaloids Theophylline Triazolam Valproate Warfarin Ref: MacDougall C. (2011). Chapter 55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.