In patients with decompensated cirrhosis on diuretic therapy with tender gynaecomastia the best diuretic to substitute is:: (A) Amiloride for spironolactone, (B) Furosemide for spironolactone, (C) Spironolactone for amiloride, (D) Torsemide for spironolactone
Answer is A. Amiloride (10-40 mg/day) can be substituted for spironolactone in patients with tender gynecomastia. Amiloride is more expensive and less effective Ref: HEPATOLOGY, June 2009