Which of the following is not directly controlled by ACTH?: (A) Glucocoicoids, (B) Androstenedione, (C) Dehydroepiandrosterone, (D) Epinephrine
Answer is D. THe secretion of the adrenal medullary hormones(epinephrine, norepinephrine and dopamine) is not controlled directly by ACTH. ACTH controls mainly secretion of adrenal coical hormones: Glucoicoids (coisol, coicosterone) and sex steroids (testosterone, DHEA, androstenedione ). Note: The major regulators of aldosterone are angiotensim II and potassium. However, ACTH can also stimulate aldosterone prooduction. Hormones secreted Regulated by Zona glomerulosa Mineralocoicoids (aldosterone) Angiotesin II, K+ Zona fasiculata Glucocoticoids (coisol, coicosterone) ACTH Zona Reticularis Sex steroids (DHEA, DHEA-S) ACTH Adrenal medulla Catecholamines(Epinephrine, norepinephrine) DIffuse sympathetic discharge(stress) REf: Guyton and Hall 13th edition Pgno: 965,966