A bed ridden female patient with catheter related UTI by beta lactamase producing Klebsiella pneumoniae. Which of the following drug will you choose?: (A) Ampicillin, (B) Beta lactams and beta lactamase inhibitors, (C) 2nd generation cephalosporins, (D) 3rd generation cephalosporins
Answer is B. Ans. b. Beta lactams and beta lactamase inhibitorRef: Harrison 19th e/P 1033Since it is a case of beta lactamase producing Klebsiella it will break down beta lactams like ampicillin and cephalosporins.Hence, a combination of beta lactams with beta lactamase inhibitor should be used.In case of ESBL producing organisms carbapenems are the drug of choice.In case the organism produces carbepenamase, tigecycline or polymyxins can be used.