In AML best prognosis is seen with: (A) Acute megakaryocytic leukemia, (B) Acute monocytic leukemia, (C) Acute promyelocytic lukemia (M3), (D) Erythroleukemia
Answer is C. - Acute Promyelocytic Leukemia (APML): characterized by a gene rearrangement involving retinoic acid receptor It is very responsive to all-trans retinoic acid (ATRA, tretinoin) combined with anthracyclines and cytarabine. The success of this therapy makes Bone marrow transplantation unnecessary in 1st remission. Arsenic trioxide is also an effective non-cytotoxic therapy for APML