Microscopic polyangiitis is characterized by the following features EXCEPT: (A) Involves small and medium sized arteries and veins, (B) 75% cases are associated with ANCA positivity, (C) Palpable purpura, ulcers and vesiculo bullous lesion, (D) Unlikely to cause pulmonary renal syndrome
Answer is D. Ans. (d) Unlikely to cause pulmonary renal syndrome(Ref: Robbins 9th/pg 510-11; 8th/pg 515)Microscopic polyangiitis (MP)Option a true- MP is small vessel vasculitisTypically spare medium-sized and larger arteriesOption b is true- P-ANCA is present is majority of the patients.Option c is true- major clinical features include hemoptysis, hematuria and proteinuria, bowel pain or bleeding, muscle pain or weakness, and palpable cutaneous purpura.Skin findings are as follows:Palpable purpura (41%), Leukocytoclastic angiitis, livedo reticularis (12%), skin ulcerations, necrosis and gangrene, necrotizing nodules and digital ischemia (7%)Urticaria - Vasculitis-associated urticaria that lasts longer than 24 hours Option d is false- Necrotizing glomerulonephritis (90% of patients) and pulmonary capillaritis are common,