A person consumes large quantities of alcohol daily since 20 years.He is physically dependent on alcohol. Drug should be given to this person is:: (A) Disulfiram, (B) Acamprosate, (C) Naltrexone, (D) Chlordiazepoxide
Answer is A. Disulfiram is the main drug tahtbsi used to make alcohol consumption an unpleasant experience. Disulfiram inhibit aldehyde dehydrogenase , alcohol is not metabolized and acetaldehyde accumulates which produces unpleasant symptoms and patient develops an aversion.All the other given drugs can be used but primarily displaces is tried. Ref: KD Tripathi 8th ed.