Increased risk of endometrial and ovarian cancer is seen in: (A) Hereditary nonpolyposis colorectal cancer, (B) Peutz-jeghers syndrome, (C) Cowden's syndrome, (D) Ataxia telangiectasia
Answer is A. HNPCC or Lynch II syndrome is caused by an inherited mutation in one of the following mismatch repair genes: hMSH2, hMLH1, PMS1, PMS2, or hMSH6. The disorder is characterized by early age (average age younger than 45 years) at onset of neoplastic lesions in a variety of tissues, including the colon, uterus, stomach, ureters, ovaries, and skin. The lifetime risk of endometrial cancer in women with Lynch II syndrome is 32% to 60% and the lifetime risk of ovarian cancer is 10% to 12%. Reference: Novak's gynecology; 14th edition; Chapter 35; Uterine cancer