In carcinoma of unknown primary, if the tissue marker CDX-2 is positive, it indicates:: (A) Bladder cancer, (B) Gastrointestinal cancer, (C) Lung cancer, (D) Thyroid cancer
Answer is B. Ans. (b) Gastrointestinal cancer(Ref: Am J Surg Pathol 2003; 27:303)CDX2: Also called caudal-related homeobox gene 2, caudal type homeobox transcription factor 2Fairly specific marker of GI origin for adenocarcinomas