Initiating event of Endotoxic shock: (A) Endothelial injury, (B) Peripheral vasodilata on, (C) Cytokinin action, (D) Decreased pumping of hea
Answer is C. The receptor for the endotoxin in humans is the TLR-4 located on the surface of antigen presenting cells. b. Binding to the receptor activates a cascade of enzymatic reactions which finally leads to the activation of the genes for the proinflammatory cytokines. Ref ganong's review of medical physiology 25e p465