The diuretic group that does not require access to the tubular lumen to induce diuresis is ?: (A) Carbonic anhydrase inhibitor, (B) Na-Cl sympo inhibitor, (C) Mineralocoicoid antagonist, (D) Na-K sympo inhibitor
Answer is C. Ans. is 'c' i.e. Mineralocoicoid antagonist Spirinolactone is mineralocoicoid (aldosterone) antagonist. It opposes the action of Aldosterone without requiring access to the tubular lumen. Spirinolactone (as well as aldosterone) act from the interstitial side.