Complement Fixation test is:: (A) WIDAL, (B) Coombs test, (C) Wassermann reaction, (D) VDRL
Answer is C. The complement fixation test (CFT) was extensively used in syphilis serology after being introduced by Wasserman in 1906. However, there is now a trend to replace the CFT with the simple flocculation tests. Although CFT is considered to be a relatively simple test, it is a very exacting procedure because 5 variables are involved. In essence the test consists of two antigen-antibody reactions, one of which is the indicator system. REF: ROBBINS pathology 10th edition