Endothelium derived relaxing factor (EDRF) induced vasodilatation is mediated by:: (A) Increased intracellular cGMP, (B) Decreased intracellular cGMP, (C) Increased extracellular cyclic AMP, (D) Decreased intracellular cyclic AMP
Answer is A. Endothelial cells produce endothelium ­derived relaxing factor (EDRF), a substance that is now known to be nitric oxide (NO).
NO and ANP hormone act via increasing intracellular cGMP.