Wilson's Disease is caused by mutation of which of the following gene?: (A) ATP 7A gene, (B) ATP7B gene, (C) ATP8A gene, (D) ATP8B gene
Answer is B. Wilson's disease is an autosomal recessive disorder caused by mutations in the ATP7B gene. Clinical manifestations are caused by copper toxicity and primarily involve the liver and the brain. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 3188