True about Wilson’s disease: (A) Decreased urinary excretion of copper, (B) Increased ceruloplasmin in blood, (C) Decreased copper and ceruloplasmin in serum, (D) Decreased urinary excretion of ceruloplasmin
Answer is C. In Wilson’s disease, there is almost always a failure of synthesis of ceruloplasmin; however, some 5% of patients have a normal circulating ceruloplasmin concentration and this is not the primary pathogenic defect. The amount of copper in the body at birth is normal but thereafter it increases steadily; the organs most affected are the liver, basal ganglia of the brain, eyes, kidneys and skeleton.