Alpha-1 antitrypsin deficiency causes: (A) Emphysema, (B) Bronchitis, (C) Bronchieactasis, (D) Pneumonia alba
Answer is A. Ans. a (Emphysema) . (Ref. Robbins, 6th/709; Harrison medicine 17th ed. 1638)EMPHYSEMA TYPES:1.Centraacinar- Most common type- Most frequently associated with smoking- Most prominent in upper lobe and superior segment of lower lobe2.Panacinar- Alphal antitrypsin deficiency- Prediliction for lower lobe3.Centrilobular-Educational point:# In alphal anti-trypsin deficiency panacinar is common, while in chronic smokers centracinar in commoner.# Garden variety: smoking related to emphysema is usually mixed.