Cachectin is produced by-: (A) Neutrophils, (B) Eosinophils, (C) Macrophages, (D) Basophils
Answer is C. Cachectin (Tumour necrosis factor - α) is produced by -

Macrophages
Monocytes
N.K. Cells

Biological effects of TNF-α

Tumor cytotoxicity
Induction of acute phase proteins
Lipolysis
Endotoxic shock
Fever
Antiviral and antiparasitic effect
Cachexia
Phagocytic cell activation