Birbeck granules in cytoplasm is seen in -: (A) Langerhans cell histiocytosis, (B) Hodgkin's lymphoma, (C) Non hodgkins lymphoma, (D) Gastrointestinal stromal tumor
Answer is A. Ans. is 'a' i.e., Langerhans cell histiocytosis Birbeck granules are characteristic of langerhans cell histiocytosisTumour cells in the laneerhan \ cell histiocytosis are derived from dendritic cells and express :-o S-100o CDlao HLA-DRo These cells are characterized by the presence of birbeck granules in their cytoplasm unde rthe electron micro-scope, Birbeck granules have pentalaminar, rodlike tuular appearance and sometimes a dilated terminal end itennis-racket appearance)