Pancreatic juice becomes thick if it has impaired: (A) Na secretion, (B) Cl- secretion, (C) Na+ H+ exchange, (D) H+ secretion
Answer is B. As the volume of pancreatic secretion increases, its Cl- concentration falls and its HCO3- concentration increases.The magnitude of the exchange is inversely propoionate to the rate of flow.In cystic fibrosis where this exchange mechanism is lost, pancreatic secretions become dehydrated and thickenedREF: GANONG&;S REVIEW OF MEDICAL PHYSIOLOGY, TWENTY-THIRD EDITION, PAGE NO:435,436