Which of the following drug inhibits the enzyme of initial step of cholesterol synthesis ?: (A) Lovastatin, (B) Gemfiberozil, (C) Probucol, (D) Cholestyramine
Answer is A. Ans. is 'a' i.e., Lovastatin o Statins (Lovastatin) competitively inhibit the conversion of HMG-CoA to mevalonate (rate limiting step in cholesterol synthesis) by inhibiting the enzyme HMG-CoA reductase.