Drug NOT used in pulmonary hypeension ?: (A) Calcium channel blocker, (B) Endothelin receptor antagonist, (C) Alpha blocker, (D) Pro stacyc lin
Answer is C. Ans. is 'c' i.e., Alpha blockers Drug for pulmonary hypeension 1. By increasing the effect of NO/cGMP o This can done by increasing the concentration of cGMP by preventing its degradation. o This can be achieved by inhibiting phosphodiesterase-5 by phosphodiesterase -5 inhibitors like sildenafil, Tadalofil. 2. By increasing the effect of Prostacyclin (cAMP) o This can be achieved by using prostacyclins like epoprostenol, Treprostinil, Iloprost. 3. By decreasing the effect of endothelin o This can be acheived by using endothelin receptor antagonists like Bosentan, ambrisentan. By having direct vasodilatory effect on pulmonary vessels. o Calcium channel blockers like nifedipine dilate both systemic and pulmonary vascular bed.