Which of the following statement is not true about tamoxifen?: (A) It is used for visceral metastasis, (B) Tamoxifen is useful in post-menopausal and aromatase inhibitors in premenopausal patients, (C) Dose is 20 mg for 5 years, (D) It can cause endometrial carcinoma
Answer is B. TAMOXIFEN AROMATASE INHIBITORS Pre-menopausal patients Post-menopausal patients Breast Ca Cells Potent antagonist Blood vessels Paial Agonist: Pit: Pituitary B: Bone U: Uterus - | risk of endometrial Ca L: Liver Dose: 10mg BD x 5 years / 20mg OD x 5yrs. - As, the menopause itself is a risk factor for endometrial cancer, tamoxifen therapy aggravates the risk. Hence tamoxifen is not prescribed for post- menopausal females. - Tamoxifen is also used for visceral and Bony metastases.