Which of the following benign lesion of breast is associated with moderately increased risk of invasive breast carcinoma?: (A) Sclerosing Adenosis, (B) Atypical lobular hyperplasia, (C) Apocrine metaplasia, (D) Squammous metaplasia
Answer is B. Atypical lobular hyperplasia refers to proliferation of lobular type cells within the acini of a lobule. It is a benign breast disease associated with 4-5 times increased risk of developing breast cancer. In this type the cellular proliferation is mild and the cells fill the acini but do not distend most of them. Ref: Common Breast Lesions: A Photographic Guide to Diagnosis and Treatment By Samuel Pilnik, Page 147; Schwaz's Principles of Surgery, 9th Edition, Chapter17; Mammography: Diagnosis and Pathological Analysis By Maon Lanyi, Page 64; Early Breast Cancer: From Screening to Multidisciplinary Management By G. Querci Della Rovere, Page 268; Managing Breast Cancer Risk By Monica Morrow, Virgil Craig Jordan, Page 59