A child died soon after bih. On examination there was hepatosplenomegaly and edema all over body. Most probable diagnosis in:: (A) a-thalassemia, (B) b-thalassemia, (C) Hereditary spherocytosis, (D) ABO incompatibility
Answer is A. - This case history suggests NON IMMUNE HYDROPS - seen in severe variety of alpha thalassemia (HbH or Hb Bas). - ABO incompatibility usually leads to mild hemolysis, which is not severe enough to lead to hydrops fetalis. - b-thalassemia - Doesn't present immediately after bih