All of the following are true statements about Down syndrome, except:: (A) Most common inheritable cause of mental retardation, (B) In quadruple test, Inhibin-A level is reduced, (C) Most common cause is meiotic non-disjunction, (D) In triple test (AFP |, estriol |, hcG |)
Answer is B. ANTENATAL SCREENING FOR DOWN SYNDROME: TRIPLE TEST b-hCG || Maternal Serum Alpha fetoprotein (MSAFP) || Unconjugated Estriol (uE3) || QUADRUPLE TEST b-hCG || Maternal Serum Alpha fetoprotein (MSAFP) || Unconjugated Estriol (uE3) || Dimeric Inhibin-A || OTHER OPTIONS Down syndrome is most common inheritable cause of mental retardation- true Most common cause of Down syndrome is meiotic non-disjunction, followed by Robesonian translocation- true