Recurrent Giardiasis is associated with:: (A) Severe combined immunodeficiency, (B) Common variable immunodeficiency, (C) Digeorge syndrome, (D) C8 deficiency
Answer is B. Common variable immunodeficiency is associated with the deficient production of antibodiesThey have a normal number of B lymphocytes but fail to mature into plasma cellsResults in hypogammaglobulinemia, with a reduction in all classes of Ig but sometimes only IgG is reducedVarious disorders associated:Intestinal disorders:Chronic giardiasisIntestinal malabsorptionAtrophic gastritis(with pernicious anaemia)Chronic pulmonary infections:bronchiectasisOthers:can also present with signs and symptoms of lymphoid malignanciesfeverweight lossanaemiasplenomegalylymphadenopathy(ref: Harrison's 18/e p1849, 2059)