Most commonly associated mutation in prostratic carcinoma is?: (A) p16\/INK4a, (B) PTEN, (C) GPST 1, (D) APC
Answer is C. Harshmohan textbook of pathology 7th edition. prostatic carcinoma- at genetic level following epigenetic phenomenon and acquired somatic mutation have been repoed in development of prostatic carcinoma. 1. Epigenetic phenomenon- hyper methylation of GSTP 1 gene promoter causing loss of function of the gene that detoxifyes carcinogens. .