Mechanism of action of quinolones is?: (A) DNA gyrase inhibitors, (B) Bind to 30 s unit, (C) Bind to bacterial cell membrane, (D) Bind to tetrahydofolate reductase
Answer is A. ANSWER: (A) DNA gyrase inhibitorsREF: Goodman G ill man s 11th ed p. 722The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram positive bacteria, topoisomerase IV is the primary target. For many gram-negative bacteria, DNA gyrase is the primary quinolone target.