Following investigations are required in initial evaluation of a chronic myeloid leukemia patient EXCEPT -: (A) Peripheral smear, (B) Test for Philadelphia chromosome, (C) Bone marrow testing, (D) HLA typing
Answer is D. CML is established by identification of the clone of hematopoietic stem cells that possesses the reciprocal translocation between chromosome 9 & 22,forming Philadelphia chromosome. Peripheral smear shows metamyelocytes, myelocytes, mature segmented neutrophils , basophils.Bone marrow examination reveals hypercellularity with predominance of myeloid cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 357