True regarding acetazolamide is ?: (A) Irreversible inhibitor of carbonic anhydrase, (B) Structural resemblance to sulfonamides, (C) It decreases Na, K, Glucose excretion, (D) It causes metabolic alkalosis
Answer is B. Ans. is 'b' i.e., Structural resemblance to sulfonamides o Acetazolamide is sulfonamide derivatives and, like other sulfonamides, may cause bone marrow depression, skin toxicity, sulfonamide like renal lesions, and allergic reactions in patients hypersensitive to sulphonamides. o Acetazolamide is reversible inhibitor of carbonic anhydrase. o It causes metabolic acidosis (net alkalosis). o K' excretion is increased.