True about imipenem is -: (A) It is a narrow spectrum antibiotic, (B) It is easily broken by beta lactam, (C) It can be used with cilastatin, (D) It is used with sulbactam
Answer is C. Ans. is 'c' i.e., It can be used with cilastatin o A limiting feature of imipenem is its rapid hydrolysis by the enzyme dehydropeptidase-I located on the brush border of renal tubular cells. Cilastatin is a reversible inhibitor of dehydropeptidase -1. It protects the imipenem from this enzyme. o Carbapenems have the widest spectrum of all currently available antimicrobials, being bactericidal against most gram positive andgram negative aerobic and anaerobic pathogenic bacteria.