Acetaminophen poisoning causes which of the following changes in the liver?: (A) Centrilobular necrosis in liver, (B) Microvesicular fatty infiltration in hepatocytes, (C) Cholestasis, (D) Peripoal inflammation
Answer is A. Acetaminophen poisoning typically causes centrilobular necrosis in liver. Ref: Harrison's Principles of Internal Medicine, 18th Edition, Page 2560, see Table: 305-1.