Histiocytosis Xis seen in except-: (A) Hand schuller Christian disease, (B) Eosinophilic granuloma, (C) Letter-siwe syndrome, (D) Torres syndrome
Answer is D. Ans. is 'd' i.e., Torres syndromeLangerhans cell histiocytosis (Histiocytosis X) o Histiocytosis X is characterized by proliferation of Langerhans histiocytes (tissue macrophages). o It is Subdivided into three Categories:-(i) Letterer-siwe syndrome(ii) Hand-Schuller-Christian disease(iii) Eosinophilic granuloma.o Tumor cells in each are derived from dendritic cells and express S-100, CD la and HLA-DR.o The presence of Birbeck granules in the cytoplasm is characteristic.o Under electron microscope, Birbeck granules have a pentalaminar, rod like, tubular appearance and sometimes a dilated terminal end (tennis-rachet appearance).