A widely used the drug that suppresses cellular immunity,inhibits prostaglandin and leukotriene synthesis and increases the catabolism of IgG antibody is: (A) Cyclophosphamide, (B) Predisone, (C) Cyclosporine, (D) Infliximab
Answer is B. Ref-KDT 6/e p828,838 Glucocoicoids are powerful immunosuppresants. These inhibit both cellular and humoral immunity by: Decreasing the recruitment of immune cells Catabolism of immunoglobulins. Inhibiting the enzyme phospholipase A, resulting in decreased production of PGs,LTs and TXs