A boy after playing football complaining fatigue and abdominal pain. He also had a history of hand swelling in past. On ultrasonography, he has shrunken spleen. What is the likely diagnosis of this patient?: (A) Sickle cell anemia, (B) Iron deficiency anemia, (C) Acute pancreatitis, (D) Intermittent porphyria
Answer is A. Sickle cell anemia b-globin hemoglobinopathy(mutation in coding sequence ofb-globin gene, GAG - GTG ) Anemia and reticulocytotic;sickle-shaped erythrocytesdemonstrable on peripheral blood smear; homozygosity forhemoglobin Sdemonstrable by electrophoresis Characterized bysevere anemia, recurrent painful and aplastic crises, and nonhealing leg ulcers; recurrent splenic infarcts with progressive fibrosisresult inauto splenectomy