About first order kinetics,true statement is: (A) Clearance remains constant, (B) Fixed amount of drug is eliminated, (C) Half life increases with dose, (D) Decreases clearance with increased dose
Answer is A. Clearance is variable in zero-order kinetics because a constant amount of the drug is eliminated per unit time, but it is constant in first-order kinetics, because the amount of drug eliminated per unit time changes with the concentration of drug in the blood Ref-KDT 6/e p32