Which one is the best prognostic factor for ALL?: (A) Hyperploidy, (B) Orgnomegaly, (C) TLC more than 50,000/mL, (D) Response to treatment
Answer is D. d. Response to treatment(Ref: Nelson's 20/e p 2437, Ghai 8/e p 599)Discussing options one by one:a. HyperploidyIntermediate prognosis; can be considered goodb. OrganomegalyL. Node, liver, spleen enlargement, Testicular enlargement - poor prognosisc. TLC >50,000/mLPoor prognosis; TLC <10,000/mL has good prognosisd. Response to treatmentEarly response to treatment is a good prognostic factor for ALL