Mechanism of action of duloxetine is ?: (A) Selective Inhibition of serotonin reuptake, (B) Selective inhibition of nor-epinephrine reuptake, (C) Selective inhibition of both serotonin and nor-epinephrine reuptake, (D) None of the above
Answer is C. Ans. C. Selective inhibition of both serotonin and nor-epinephrine reuptakeDuloxetine, is a drug classified under serotonin-norepinephrine reuptake inhibitors (sNRJs).At lower doses it is more prominent serotonin reuptake inhibitor.Whereas at higher doses it is more prominent inhibitor of nor-epinephrine reuptake.It has minimal dopamine agonist action.