Phenytoin pharmacokinetics is highlighted by which of the following characteristics?: (A) High first pass metabolism, (B) Nonsaturation kinetics of metabolism, (C) Capacity limited metabolism saturating at higher therapeutic concentration range, (D) Extrahepatic metabolism
Answer is B. (Ref: KDT 6/e p404) Phenytoin follows zero order kinetics at high plasma concentration due to saturation of metabolic pathways.