All of the following are recommendations for screening of lynch syndrome in women with endometrial cancer except: (A) Evidence of microsatellety instability, (B) DNA mismatch repair protein loss, (C) Endometrial cancer before 60 years of age, (D) 1st or 2nd degree relative with known DNA mismatch repair gene mutation
Answer is C. Lynch syndrome Genetic Screening Recommendations
Patients with endometrial or colorectal cancer and tumor evidence of:
Microsatellite instability or 
DNA mismatch repair protein loss
Fisrt-degree relative with endometrial or colorectal cancer who was diagnosed:
Before age 60 years or 
Is at risk for Lynch syndrome based on personal and medical history.
First- or second-degree relative with a known DNA mismatch repair gene mutation.