Warfarin induced skin necrosis is seen in:: (A) Protein C deficiency, (B) Sickle cell anemia, (C) Factor V leiden deficiency, (D) Antithrombin 3 deficiency
Answer is A. It is due to decreased levels of protein C. It is more likely to occur in patients with genetic deficiency of protein C. Most common side effect of warfarin:Bleeding Dermal vascular necrosis is early appearing adverse effect. Due to decreased osteocalcin synthesis Warfarin causes nasal hypoplasia and therefore contraindicated in pregnancy