Which of the following estimates blood creatinine level most accurately -: (A) Jaffe method, (B) Kinetic jaffe method, (C) Technicon method, (D) Enzyme assay
Answer is D. Among the given options, the enzyme assay is the most accurate.
Methods to measure serum creatine to assess GFR are:-

i) Gas chromatography-isotope dilution mass spectroscopy (GC-IDMS):- It is the most accurate and method of choice.
ii) High-performance liquid chromatography (HPLC).
(iii) Enzymatic creatinine method (enzyme assay).
(iv)Alkaline picrate methods:- Jaffe method

Accuracy in decreasing order is GC-IDMS > HPLC > Enzyme assay > Alkaline picrate (Jaffe) method.