Mast cell stabilizer used in Bronchial Asthma is: (A) Raloxifene, (B) Ketotifen, (C) Azelastin, (D) Baclofen
Answer is B. Mast cells are impoant in initiating the acute bronchoconstrictor responses to allergens & several other indirectly acting stimuli like exercise and hyperventillation.Ketotifen is a mast cell stabilizer which reduces the stimulation of mast cells and mediator release is reduced(histamine,PGD2,leukotrienes). Dose:1-2 mg BD;children 0.5 mg BD Reference:Harrison' s medicine-18th edition,page no:2104;Textbook of pharmacology-K D Tripathi,7th edition,page no:229