A 30-year-old African-American woman presents with bilateral hilar lymphadenopathy and reticular densities in both lung fields. Which of the following is a defining characteristic of the disorder suggested by these findings?: (A) Noncaseating granulomas, (B) Hypocalcemia, (C) Impaired synthesis of immunoglobulin, (D) Caseation and necrosis may occur
Answer is A. The clinical picture strongly suggests a diagnosis of sarcoidosis. The granulomas of sarcoidosis are characteristically noncaseating. Sarcoidosis is a multisystem disorder. Common findings include anergy to tuberculin, hypercalcemia, and broad-based polyclonal hypergammaglobulinemia. Sarcoidosis : Significant elevation of angiotensin-conveing enzyme (ACE).