Time required to reach the steady state after a dosage regimen depends on:: (A) Route of administration, (B) Half life of a drug, (C) Dosage interval, (D) Dose of drug
Answer is B. Ans. (B) Half life of a drug(Ref: KDT 8th/e p40-41)* After a dosage regimen, concentration of the drug to reach the steady state (when the elimination balances the input) is called steady state plasma concentration Cpss.* Cpss is reached in about 4-5 half lives.* The amplitude of fluctuations in Cpss depends on the dose interval relative to t1/2 .