Predictable and dose related drug induced hepatic injury is seen with all, EXCEPT:: (A) Carbon tetrachloride, (B) Acetaminophen, (C) INH, (D) Oral contraceptive agent
Answer is C. There are two major types of chemical hepatotoxicity Direct toxicity-Predictable with sho latent period Idiosyncratic-Not predictable and it can happen at any time Examples of direct hepatotoxic effects Carbon tetrachloride Acetaminophen OCP INH causes idiosyncratic type reaction Hepatitis is infrequent and unpredictable Ref: Harrison, Edition-18, Page-2558