All true about CisATRACURIUM except-: (A) It is pure Cis isomer of atracurium, (B) It is more potent than atracurium, (C) It is also causes histamine release like atracurium, (D) Metabolism similar to atracurium
Answer is C. Cisatracurium is pure sis isomer of atracurium. It is more potent and has longer onset time than atracurium. Metabolism is similar to atracurium. It releases less histamine than atracurium. Cisatracurium does not cause histamine release unlike atracurium. Cisatracurium produces laudanosine but is about five times lesser than that of atracurium. Cisatracurium is a stereoisomer of atracurium that is four times more potent. Cisatracurium undergoes Hofmann Elimination which is a spontaneous non-enzymatic organ-independent degradation. So its clearance is independent of renal function. Hence it is the agent of choice in renal failure patients.