All of the following statements about amlodipine are true except:: (A) It acts by conversion to an active metabolite in the liver, (B) It has a very large volume of distribution, (C) It undergoes very little first pass metabolism and possesses high and consistent oral bioavailability, (D) It has a very long elimination half life
Answer is A. (Ref: KDT 6/e p531) Amlodipine is the longest acting DHP. It undergoes little first pass metabolism and is distributed widely. metabolites of amlodipine are inactive.