Pathologic features of brain in AIDS are all, except-: (A) Perivascular giant cell invasion, (B) Microglial nodules, (C) Vasculitis, (D) Temporal lobe infarction
Answer is C. Ans. is 'c' i.e., Vasculitis Other characteristic pathologic feature of CNS in AIDS are : o Diffuse and focal spongiform changes Vacuolar myelopathy of post column of spinal cord. o Major cells affected are macrophages and monocytes. o Most characteristic finding is chronic inflammatory reaction with widely distributed infiltrates of microglial nodules. "Unlike most other viral encephalitides, HIV does not seem to infect neurons and perivasculitis is conspicuously absent" - page 2728, 10"le ANDERSON pathology. "Characteristic multinuclear Giant Cells of macrophage origin are seen in deep white matter of frontal and temporal lobes paicularly in perivascular location"