Digoxin toxicity is increased by all except:: (A) Renal impairment, (B) Hyperkalemia, (C) Hypercalcemia, (D) Hypomagnesemia
Answer is B. Hypokalemia increases the binding of digoxin to Na-k ATPase and enhances its toxicity. Hypokalemia decreases digoxin toxicity Diuretics also interfere with the action of digoxin (REF. Essentials of medical pharmacology KD TRIPATHI 8th Edition)