Insulin acts on glucose metabolism by: (A) | permeability of glucose across cell membrane, (B) | permeability of glucose across cell membrane against glucose gradient, (C) | permeability of renal cells, (D) | glucose transpo to brain
Answer is B. Insulin signals the cells of insulin-sensitive peripheral tissues, primarily skeletal muscle, to increase their uptake of glucose.Secondly, insulin acts on the liver to promote glycogenesis.Finally, insulin simultaneously inhibits glucagon secretion from pancreatic a-cells, thus signalling the liver to stop producing glucose glycogenolysis and gluconeogenesis Ref: DM Vasudevan, 7th edition, page no: 165, 318, 323