A patient with Miller Dieker syndrome on neuroimaging showed a smooth coex with no involutions. This condition of the brain where the convolutions are absent is called?: (A) Holoprosencephaly, (B) Lissencephaly, (C) Rachischisis, (D) Arhinencephaly
Answer is B. Smooth cerebral coex with no convolutions is called Lissencephaly. It may be associated with microcephaly, developmental delay, seizure, optic nerve hypoplasia and microphthalmia. Holoprosencephaly means a single sphered brain. Rachischisis is congenital fissure of veebral column. Ref: Oxford Handbook of Clinical Specialities, Edition 8, Page - 139