All are Characteristic of SAPHO syndrome except: (A) Synovitis, (B) Acne, (C) Pustulosis, (D) Hyperpigmentation
Answer is D. The syndrome of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) characterized by a variety of skin and musculoskeletal manifestations. Dermatologic manifestations include palmoplantar pustulosis, acne conglobate, acne fulminans, and hidradenitis suppurativa. Reference: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 385; Vasculitis Syndromes