Which of the following antihypeensives does not alter serum glucose and lipid levels?: (A) Propanolol, (B) Prazosin, (C) Thiazide diuretics, (D) Furosemide
Answer is B. Prazosin doesn't impair carbohydrate metabolism, suitable for diabetes mellitus, it has only a slight effect on lipid profile. Prazosin is a selective alpha 1 antagonist. Diuretics - cause hyperlipidemia and hyperglycemia Beta-blockers- by blocking beta 2 receptors on liver-could cause hyperglycemia to a slight extent and hyperlipidemia K.D. Tripathi : Essentials of medical pharmacology, seventh edition, page no 564