True statements about neostigmine are: (A) It is a quaternary ammonium compounds, (B) It is metabolized by the liver, (C) It can cross the blood brain barrier, (D) Prominent effect on cardiac muscle
Answer is A. (Ref. KDT6/e p101-102; Lee 12/ep217) Neostigmine is a reversible cholinesterase inhibitor.It is a quaernary ammonium compound. (lipid insolube agent), so it does not cross blood-brain-barrie. It is paly hydrolyzed by serum cholinesterase and paly excreted unchanged by the kidneys. It possesses some agonistic action on NM receptors.