Collagen accumulated in space of Disse in case of liver cirrhosis are: (A) 1 and 4, (B) 2 and 4, (C) 1 and 3, (D) 2 and 3
Answer is C. In the normal liver, ECM consisting of interstitial collagens(fibril forming collagen types I, II, V and XI) is present only in the liver capsule, in poal tracts and around central veins. In cirrhosis, types I and III collagen and other ECM components are deposited in the space of disse. ROBBINS BASIC PATHOLOGY NINTH EDITION PAGE 607