Congenital 17-hydroxylase deficiency leads to hypeension due to accumulation of?: (A) Deoxycoicosterone, (B) Coisol, (C) 17 hydroxy pregnediol, (D) 17 hydroxy progesterone
Answer is A. * Two forms of adrenal hyperplasia (ie, 11-hydroxylase and 17-hydroxylase deficiency) result in hypeension due to the accumulation of supraphysiologic concentrations of deoxycoicosterone. * This weak mineralocoicoid has little consequence at physiologic concentrations but causes sodium retention and hypeension at the supraphysiologic concentrations that occur in these conditions.