Aldose reductase inhibitor drugs are useful in?: (A) Cataract, (B) Diabetes mellitus, (C) Hereditary' fructose intolerance, (D) Essential fructosuria
Answer is B. Ans. is 'b' i.e.. Diabetes mellitus o Aldose reductase catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step in polyol pathway of glucose metabolism.o Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes mellitus.o Examples of aldose reductase inhibitors include:Tolrestat (withdrawn from market)A pa l res tatRanirestatFidarestat