Kuru plaques are seen in which of the following neurodegenerative disorders?: (A) Alzheimer disease, (B) Creutzfeldt-Jakob Disease (CJD), (C) Parkinson disease (PD), (D) Multiple system atrophy (MSA)
Answer is B. CNS Inclusions seen in neurodegenerative disorders Disease Inclusions Prion diseases (Creutzfeldt-Jakob Disease (CJD)) Kuru plaques and diffuse PrP (Prion related protein) deposits Alzheimer disease Ab (plaques) and tau (tangles) Parkinson disease a-synuclein; tau Multiple system atrophy (MSA) a-synuclein Huntington disease Huntingtin Spinal bulbar muscular atrophy (SBMA) Androgen receptor Progressive supranuclear palsy (PSP), Coicobasal degeneration (CBD) tau