Regarding severe combined immunodeficiency, which is true?: (A) Adenosine deaminase deficiency, (B) Decreased circulating lymphocytes, (C) NADPH oxidase deficiency, (D) C1 esterase deficiency
Answer is A. Severe combined immunodeficiency Constellation of genetically distinct syndromes Defects in both humoral & cell-mediated immune response MC form - XLR - so more in males; mutation in g chain subunit of cytokine receptors Remaining - AR; deficiency of enzyme ADA