All of the following constitute familial cancer syndrome except -: (A) Xeroderma-pigmentosum, (B) Retinoblastoma, (C) Neurofibromatosis, (D) MEN-I
Answer is A. All are familial cancer syndromes.
Xeroderma-pigmentosa is autosomal recessive, defective DNA repair syndrome.
Other three are autosomal dominant inherited cancer syndrome.
Amongst the given options best answer is a i.e. xeroderma pigmentosa because autosomal dominant inherited cancer syndromes are the most common type of genetically predisposed cancer.