Which of the following statements is true of hereditary spherocytosis (HS)?: (A) Pigment-type of gall stones are common, (B) Diagnosis can be made in neonatal period easily by examination of a blood film, (C) Intravascular hemolysis is a common feature, (D) Autosomal recessive inheritance in majority of the cases
Answer is A. Discussing the options about HS - a. TRUE D/t chronic hemolysis, pigmented stones are formed in gall bladder. b. FALSE In newborns, Spherocytosis & reticulocytosis are frequently minimal or absent c FALSE Hemolysis in hereditary spherocytosis is mainly extravascular d. FALSE 75% cases of HS have autosomal dominant inheritance Anisocytosis and several hyperchromic spherocytes are seen. Howell-Jolly bodies can be seen.