All of the following are pre-leukemic conditions except: (A) Paroxysmal nocturnal hemoglobinuria, (B) Paroxysmal cold hemoglobinuria, (C) Aplastic anemia, (D) Myelodysplastic syndrome
Answer is B. - Paroxysmal cold hemoglobinuria aka cold hemolysin disease is associated with cold AIHA (Auto Immune Hemolytic Anemia). Its not pre-leukemic condition. Special antibody seen in this condition is Donath-Landsteiner Ab against P antigen. Most cases are seen in children following viral infections; in this setting the disorder is transient, and most of that affected recover within 1 month. - Remaining all conditions given in options are pre-leukemic conditions.