Hydroxylation of proline in collagen requires which of the following:: (A) Vitamin C, (B) Fe2++, (C) a-ketoglutarate, (D) All of the above
Answer is D. Ans. D. All of the aboveProline and Lysine are hydroxylated to form hydroxyl proline and hydroxyl lysine in the presence of enzyme hydroxylase and requires Fe2++' ascorbic acid (Vitamin C), oxygen and a- ketoglutarate.