Mechanism of action of Aspirin: (A) Inhibit PGI2 formation, (B) Inhibit TXA2 formation, (C) Stimulate TXA2 formation, (D) Stimulate platelet aggregation
Answer is B. Ans. (b) Inhibit TXA2 formationRef KDT 6th ed. / 609; Katzung 9th ed. / 446Thromboxane helps in platelet aggregation.* TXA2 formation is suppressed at very low doses of aspirin.* Aspirin blocks thromboxane formation by inhibiting COX activity by enzyme COX1 and TX- synthase irreversibly.