Amiloride can cause hyperkalemia due to its action on:: (A) Potassium channel, (B) Sodium channel, (C) Na+ Cl- symporter, (D) H+K+ATP ase
Answer is B. Ans. B. Sodium channelAmiloride and triamterene are K+ sparing diuretic, they act by inhibiting epithelial Na+ channel. When they inhibit the sodium channel, there is no generation of electrical gradient and thus potassium and hydrogen are not excreted. They may be responsible for hyperkalemia.