Toxicity of ethanol is due to:: (A) Increased NADH/NAD+ ratio, (B) Decreased lactate/pyruvate ratio, (C) Inhibition of gluconeogenesis, (D) Stimulation of fatty acid oxidation
Answer is A. Ans. A. Increased NADH/NAD+ ratioHigh concentration of NADH leads to high NADH/NAD+ ratio. This is the basic cause of all metabolic alteration in alcoholism.