Tumor Suppressor Gene associated with Familial gastric cancer and Lobular breast carcinoma is: (A) RB, (B) PTEN, (C) APC, (D) CDH1
Answer is D. GeneProteinFunctionFamilial syndromesSporadic CancersCDH1E-cadherinCell adhesion,inhibition of cell motilityFamilial gastric cancerGastric carcinoma, Lobular breast carcinomaRef: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 7; Neoplasia; Page no: 291; Table: 7-7