All except one are unfavourable signs in early Hodgkin's Lymphoma: (A) Elevated ESR, (B) Extranodal disease, (C) Stage A, (D) Four or more regions involved
Answer is C. Unfavourable signs in early Hodgkin's Lymphoma:-

Large mediastinal mass
Extranodal disease
Elevated ESR
4 or more involved regions
Presence of B symptoms.