rtPA is NOT a contraindication in stroke with: (A) BP >185/110 mm Hg, (B) Heparin in the past 24 hrs, (C) Coma, (D) Lesion occupying >1/3 of middle cerebral artery territory
Answer is C. (C) Coma # rtPA (Alteplase) is indicated in pulmonary embolism, myocardial infarction, and stroke.> rtPA therapy in patients with stroke is contraindicated in certain situations like suspicion of subarachnoid hemorrhage on pretreatment evaluation, recent (within 3 months) intracranial or intraspinal surgery, history of intracranial hemorrhage, uncontrolled hypertension at time of treatment, active internal bleeding, known bleeding diathesis (eg, current use of oral anticoagulants, administration of heparin within 48 hours of onset of stroke), platelet count <100,000/mm3.