Familial hypercholesterolemia is characterized by-: (A) Increased LDL, (B) Decreased lipoprotein lipase, (C) Increased VLDL, (D) All of the above
Answer is A. Ans. is 'a' i.e., Increased LDL Type IType IIaType IIbType IIIType IVType VProblemo Decreased lipoprotein lipase or Apo C-IIo LDL receptor deficiencyo |LDL receptor, increased Apo B-100o Defect in Apo-Eo Increased VLDL production and decreased elimination (Due to apo V deficiency)o Same as in type IV, but more severeLipoproteino Elevated chylomicrons (also VLDL some times)o |LDLo |VLDLo |LDLo Increased chylomicron remnants and IDLo |VLDLo |VLDL and chylomicronCholesterol|||||||||N|||Triglyceride||||N|||||||||NomenclatureFamilial lipoprotein lipase deficiencyo Familial hyper choleserolemiao Familial combined hyperlipidemiao Familial dys- beta lip oprei- nemiao Familial hypertriglyceridemiao Endogenous hypertrigly- cedemia