Bleomycin toxicity affects which organ predominantly?: (A) Bone marrow, (B) Lungs, (C) Liver, (D) RBC
Answer is B. Bleomycin is metabolized by bleomycin hydrolase. This enzyme is deficient in skin and lungs. Therefore, the major adverse effects of bleomycin are: Flagellated pigmentation of skin Pulmonary fibrosis