Which gene is involved in pathogenesis of Type 1 Diabetes mellitus?: (A) CTLA-4, (B) ABCD1, (C) HNF-1 Alpha, (D) HNF-4 Alpha
Answer is A. Polymorphism in promoter region of insulin gene, CTLA-4 contributes to susceptibility to type 1 Diabetes mellitus. The most common cause of type 1 diabetes mellitus is autoimmunity. Most patients have DR3 and/ or DR4 haplotype.