The peripheral smear of Hereditiary spherocytosis will show spherocytes -: (A) Usually of same size as RBCs, (B) Reticulocytosis absent, (C) Anemia is negligible, (D) Smaller size than RBCs
Answer is D. Various mutations involving membrane skeletal proteins weakens interactions b/w proteins and cause red cells to lose memb fragments . This causes decrease in size of the spherocytes compared to normal RBCs Ref: Robins 9/e pg:632