Mechanism of resistance of tetracyclines is due to?: (A) Drug efflux mechanism, (B) Development of inactivating enzymes, (C) DNA methylation, (D) Cell wall alteration
Answer is A. Mechanism of Resistance Examples Enzymatic breakdown A: Aminoglycosides B: Beta lactams C: Chloramphenicol Decreased permeability Aminoglycosides Efflux pumps Tetracyclines Altered metabolic pathway Sulfonamides Altered target MRSA Vancomycin, Fluoroquinolones