ADAMTS-13 is a metalloproteinase. It is produced by the:: (A) Alfa cells of the pancreas, (B) Oligodendrocyte in the brain, (C) Stellate cells in the liver, (D) Tubular epithelial cells of the kidney
Answer is C. Ans. C. Stellate cells in the liverADAMTS-13 is a metalloproteinase which is produced by the stellate cells of the liver. It cleaves von Willebrand factor. Therefore, when ADAMTS-13 deficiency occurs, large multimer of VWF attach to platelets and cause microcirculatory failure.