Which of the following regarding thrombotic thrombocytopenic purpura is false?: (A) Renal failure, (B) Schistocytes in peripheral smear, (C) High ADAMTS13 activity, (D) Transient neurological deficits
Answer is C. Features of TTP: fever, thrombocytopenia, microangiopathic hemolytic anemia, transient neurologic deficits, and renal failure. microangiopathic hemolytic anemia produces fragmented red cells/schistocytes which can be seen in peripheral blood smear. ADAMTS13 deficiency is present which may be inherited or acquired (because of autoantibodies against ADAMTS13).