False about kernicterus is _______: (A) No long term effect, (B) Occurs with bilirubin more than 25 mg %, (C) Deposition in basal ganglion, (D) Opisthotonus
Answer is A. When blood level of bilirubin is more than 20 mg/dl the capacity of albumin to bind bilirubin is exceeded.in young children before the age of i year, the blood brain barrier is not fully developed and therefore free bilirubin enters the brain .It is deposited in basal ganglia,leading to mental retardation,fits,encephalitis and spasticity. Ref : TEXTBOOK OF BIOCHEMISTRY,D.M.VASUDEVAN,PG NO:252,6th edition