Which among the following statements is wrong: (A) Light chains are synthesised in slight excess normally in plasma cells, (B) Qualitative assessment of M component can be done by electrophoresis, (C) M components are detected in chronic myeloid leukaemia, (D) In 20% myelomas, only light chains are produced
Answer is B. Qualitative assessment of M component is done by immune electrophoresis. Electrophoresis is used for quantitative assessment of M component. M component can also be detected in other lymphoid malignancies, CML, Can breast, colon cancer , non neoplastic condition like cirrhosis, sarcoidosis, rheumatoid ahritis, myasthenia gravis. Ref : Harrison's Principles of Internal Medicine, 21st Edition, p 710-712.