Gene responsible for FAP is located at: (A) Chromosome 5, (B) Chromosome 8, (C) Chromosome 15, (D) Chromosome X
Answer is A. Familial adenomatous polyp(FAP) is inherited as an autosomal dominant neoplastic condition (chromosome 5q21). It has a high potential for malignant transformation. It presents in younger age group- 15-20 yrs; equal in both sexes. It commonly involves the large intestine but can also occur in stomach, duodenum and small intestine. Reference : page 899 SRB's manual of surgery 5th edition