Which of the following drug bind to tubulin and arrest metaphase of the cell cycle?: (A) Vincristine, (B) Carmustine, (C) Infliximab, (D) Methotrexate
Answer is A. Vinca alkaloids, griseofulvin, taxanes, albendazole act on metaphase of cell cycleVinca alkaloids inhibit polymerization of microtubulesTaxanes inhibit depolymerization of microtubulesGoodman Gillman 12th ed. Pg 1705.