Thiamin status of an individual can be detected by which of the following tests/enzymes in erythrocytes?: (A) Transaldolase, (B) Glucose-6-phosphatase, (C) Transketolase, (D) Enolase
Answer is C. Severe thiamine deficiency is associated with: Decreased RBC transketolase activity this is the earliest manifestation seen even before clinical disturbances Thiamin is a cofactor of Transketolase pyruvate, alpha-ketoglutarate and lactate level in blood increases in thiamine deficiency ref: DM Vasudevan 8th ed page 467