The primary reason for the use of drug combination in the treatment of tuberculosis is: (A) Ensure patient compliance with the drug regimen, (B) Enhance activity against metabolically inactive mycobacteria, (C) Delay or prevent emergency of resistance, (D) Provide prophylaxis against other bacterial infection
Answer is C. Ref-KDT 6/e p745 The bacteria that cause tuberculosis (TB) can develop resistance to the antimicrobial drugs used to cure the disease. Multidrug-resistant TB (MDR-TB) is TB that does not respond to at least isoniazid and rifampicin, the 2 most powerful anti-TB drugs. ... In some cases even more severe drug-resistant TB may develop.