Poorest prognosis in AML is seen in which cyiogcnetic abnormality-: (A) Monosomy 7, (B) No cytogenetic abnormality, (C) t(l5,i7), (D) inv, 16
Answer is A. Monosomy 7 or paial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia (MDS) and acute myelogenous leukemia (AML) Ref Davidson 23rd edition pg 789