ratelimiting enzyme in fatty acid synthesis ?: (A) malonyl co a synthase, (B) acyl co synthase, (C) malonyl co a reductase, (D) cholestrol acyl transferase
Answer is A. Fatty Acid Synthesis * Fatty acids are built from 2-C units derived from acetyl-CoA * Acetate units are activated for transfer to growing FA chain by conversion to malonyl-CoA * Decarboxylation of malonyl-CoA and reducing power of NADPH drive chain growth * Chain grows to 16-carbons (eight acetyl-CoAs) * Other enzymes add double bonds and more ref : lipincott 9th ed