Which among the following is false regarding Huntington's disease?: (A) Chorea, (B) Early onset of memory loss, (C) Cog-wheel rigidity, (D) Behavioral disturbance
Answer is B. HD patients eventually develop behavioral and cognitive disturbances and the majority progress to dementia. So early onset of memory loss is not a feature of Huntington's disease. HD is characterized by rapid, nonpatterned, semipurposeful, involuntary choreiform movements. Dysahria, gait disturbance, and oculomotor abnormalities are common features. With advancing disease, there may be a reduction in chorea and emergence of dystonia, rigidity, bradykinesia, myoclonus, and spasticity. Depression with suicidal tendencies, aggressive behavior, and psychosis can be prominent features. Ref: Harrison's Internal Medicine, 18th Edition, Page 3330