In Wilm's tumor the following leads to emergence of resistance to chemotherapy:: (A) Nephrogenic rests, (B) Monophasic morphology, (C) Anaplasia, (D) Capsular infiltration
Answer is C. Wilm's tumor : 5% of tumors reveal anaplasia- Large, hyperchromatic, pleomorphic nuclei and abnormal mitoses . The presence of anaplasia correlates with underlying p53 mutation -Emergence of resistance to chemotherapy.