Mitochondrial chromosomal abnormaity leads to ?: (A) Lebers hereditary optic neuropathy, (B) Angelman syndrome, (C) Prader villi syndrome, (D) Myotonic dystrophy
Answer is A. Ans. is 'a' i.e., Lebers hereditary optic neuropathy o Diseases associated with mitochondrial inheritance are rare and many of them affect the neuromuscular system. o Leber hereditary optic neuropathy is a prototype of this disorder. It is a neurodegenerative disease that manifests itself as progressive bilateral loss of central vision. Visual impairment is first noted between ages 15 and 35, and it leads to blindness. Cardiac conduction defects & minor neurologic manifestations have also been seen in some families.