In genetic deficiency of MPO, the increased susceptibility to infection is due to:: (A) Defective production of Prostaglandins, (B) Defective rolling of' neutrophils, (C) Inability to produce hydroxyl halide radicals, (D) Inability to produce hydrogen peroxide
Answer is C. In MPO deficiency there is decreased microbial killing because of defective MPO--H2O2 system, so there is an inability to produce hydroxyl halide radicals.