RBC transketolase deficiency is seen in: (A) Thiamine deficiency, (B) Folic acid deficiency, (C) Anaemia, (D) Vitamin B12 deficiency
Answer is A. (A) Thiamine deficiency# TRANSKETOLASE is an enzyme of both the pentose phosphate pathway.> Transketolase activity is decreased in deficiency of thiamine, which in general is due to malnutrition. Two diseases are associated with thiamine deficiency: beriberi and Wernicke-Korsakoff syndrome.> Red blood cell transketolase activity is used in the diagnosis of Wernicke's encephalopathy and other B1-deficiency syndromes if the diagnosis is in doubt.