Which of the following is not seen in extraglandular Sjogren disease?: (A) Rheumatoid ahirits, (B) Raynaud phenomenon, (C) Lymphoma, (D) Splenomegaly
Answer is D. Sjogren syndrome :*An autoimmune disease which targets exocrine glands*Most common glands which are affected are lacrimal glands and salivary glands causing keratoconjunctivitis sicca (dry eyes) and xerostomia (dry mouth).*Serology shows raised SS-A (Ro) and SS-B (La) antibodies*Autoantigens against which the antibodies are produced is alpha-fodrin (though not confirmed)*Extraglandular manifestations: Rheumatoid ahritis, Synovitis, diffuse pulmonary fibrosis, peripheral neuropathy, Raynaud phenomenon and marginal zone lymphoma. ( Ref: Robbins 8/e p221)