The immediate precursor in the formation of acetoacetate from acetyl-CoA in the liver is:: (A) Mevalonate, (B) HMG-CoA, (C) Acetoacetyl-CoA, (D) 3-hydroxyl-butyryl-CoA
Answer is B. Ans. B. HMG-CoA(Ref: Harper 31/e page 210)Hydroxy-3-methylglutaryl-CoA lyase then causes acetyl-CoA to split off from the HMG-CoA, leaving free acetoacetate.