All of the following statements about clonidine are true EXCEPT: (A) It is an alpha adrenergic agonist, (B) It can cause dry mouth as an adverse effect, (C) Prazosin completely antagonizes its action, (D) It inhibits sympathetic outflow.
Answer is C. Clonidine is a central sympatholytic. It is an agonist to alpha2 receptors. But prazosin is a selective alpha1 blocker selective alpha 2 blocker is yohimbine Clonidine can cause dryness of mouth, nose, and eyes due to central sympatholytic action. (REF. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D TRIPATHI-6th edition. Page No.545,546)