Which anti-cancer drug affects DNA as well as RNA?: (A) 5-FU, (B) Methotrexate, (C) Actinomycin-D, (D) Etoposide
Answer is C. Actinomycin-D is one of the anti-tumor antibiotic. It has two mechanisms of action: - It blocks RNA transcription by interfering with template function of DNA. - It causes single strand breaks in the DNA. It is used in the treatment of Wilm's tumor and rhabdomyosarcoma.