L-Dopa is combined with carbidopa in the treatment of parkinsonism to -: (A) Decrease the efficacy of levodopa, (B) Decrease the efficacy of levodopa, (C) Increase the dose of levodopa required, (D) Inhibit conversion of levodopa to dopamine in the CNS
Answer is B. Ans. is 'b' i.e., Inhibit peripheral decarboxylation of levodopa Carbidopa is combined with levodopa to inhibit peripheral decarboxylation of levodopa and make more levodopa available to cross the blood brain barrier to reach its site of action.