Yellowing of the skin occurs in hypothyrodism because of -: (A) Increased bilirubin, (B) Increased obolesterol, (C) Increased carotene, (D) Increased
Answer is C. The yellow tinge to the skin in hypothyroidism is due to carotene accumulation. This is because the conversion of beta-carotene (provitamin A) to 2 molecules of vitamin A (retinol) is accelerated by thyroxine and thus in hypothyroidism there is hyper beta-carotenemia. Reference : page 2291 Harrison's Principles of Internal Medicine 19th edition