Acantholysis is due to destruction of :: (A) Epidermis, (B) Subepidermis, (C) Intercellular substance, (D) Basement membrane
Answer is C. Ans. is 'c' Intercellular Substance It is loss of cohesion b/w epidermal cells due to destruction of intercellulare substance. IgG Antibodies are formed against the intercellular substance.Acantholysis occurs in stratum Basale in Pemiphus Vulgaris*Acantholysis is demonstrated by Nikolsky's sign*Acantholytic cells are demonstrated by Tzanck smear*