Which of the following is true about factor V leiden mutation?: (A) Increased bleeding tendency, (B) Factor V becomes resistant to cleavage by protein C, (C) Arginine to glycine substitution, (D) Deficiency of factor V
Answer is B. Factor V Leiden mutation is hypercoagulable disorder characterized by deep venous thrombosis and pulmonary thromboembolism. Factor V becomes resistant to cleavage by protein C. It occurs due to arginine to glutamate substitution. Factor V deficiency is known as Para hemophilia.