Most common antibody in sjogren syndrome: (A) Anti-DNA topoisomerase, (B) Anti-Centromere, (C) Anti-RNA polymerase, (D) Anti-Ribonucleoprotein
Answer is D. Ans. (d) Anti-Ribonucleoprotein(Ref: Robbins 9th/pg218; 8th/pg213)Autoantibodies in Sjogren's syndrome:Anti SS-A (Ro) and SS-B (La) Q: Most important, present in 90% patients;High titers of Anti SS-A - more likely to have early disease onset, longer disease duration, and extra- glandular manifestations (eg cutaneous vasculitis and nephritis)Rheumatoid factor (an antibody reactive with self IgG): in 75% Q, ANA: in 50% to 80%