Proton pump inhibitors are most effective when they are given:: (A) After meals, (B) Shortly before meals, (C) Along with H2 blockers, (D) During prolonged fasting periods
Answer is B. Ans. (B) Shortly before meals(Ref: KDT 8th/e p700)Proton pump inhibitors are used just before meals. Food stimulates the secretion of gastric acid that will be reduced by PPIs if these are given just before meals.