The most potent anti-leprotic drug is?: (A) Rifampicin, (B) Dapsone, (C) Clofazimine, (D) Sulfasalazine
Answer is A. Rifampicin is bactericidal for M. leprae in very low dosage and acts much more rapidly than Dapsone, rendering the patient non-contagious in a few days or weeks. It acts by inhibiting DNA dependent RNA polymerase.