Which of the following drugs reduces the activity of phospholipase A2?: (A) Alprostadil, (B) Aspirin, (C) Ibuprofen, (D) Prednisolone
Answer is D. Prednisolone: It is a powerful anti-inflammatory agent. It acts by inhibiting the synthesis of PG, TX and LT the inhibition of phospholipase A2 enzyme. It is most impoant mechanism of anti-inflammatory action is the inhibition of chemotaxis.