Adenosine deaminase deficiency is seen in the following -: (A) Common variable immunodeficiency, (B) Severe combined immunodeficiency, (C) Chronic granulomatous disease, (D) Nezelof syndrome
Answer is B. Severe combined immunodeficiencies include syndrome with severe deficiency of both humoral and cell mediated response. Adenosine deaminase deficiency is a distinct pattern of SCID. - ADA catalyses the conversion of adenosine to inosine in the purine metabolic pathway. This condition is associated with chondrocyte abnormalities. Reference : Anathanarayan & paniker's 9th edition, pg no:174,175 <\p>