In a case of Dysgerminoma of ovary one of the following tumor markers is likely to be raised.: (A) Serum HCG., (B) Serum alphafetoprotein., (C) Serum lactic dehydrogenase., (D) Serum inhibin.
Answer is C. Placental alkaline phosphatase (PLAP) and lactate dehydrogenase (LDH) are produced by up to 95% of dysgerminomas, and serial measurements of LDH may be useful for monitoring the disease. A karyotype should be obtained preoperatively for all premenarcheal girls, paicularly those with dysgerminomas, because of the propensity of these tumors to arise in dysgenetic gonads