Military policy dictates that flight personnel in Iraq receive primaquine chemoprophylaxis for Plasmodium vivax malaria on redeploying to a non-malarious area. Several days after beginning such a regimen, a 26-year-old African-American pilot develops anemia, hemoglobinemia, and hemoglobinuria. Special studies will likely reveal an abnormality in which of the following?: (A) Duffy antigen, (B) G6PD, (C) Intrinsic factor, (D) PIG-A
Answer is B. - Question shows features of hemolysis after giving anti-malarial drug . - This along with history suggests the diagnosis of G6PD deficiency. - Conditions resulting in oxidative stress are: Infections - Pnemonia, sepsis etc Drugs- anti malarials, sulfa drugs, anti-TB drugs Foods