In a young female of reproductive age an absolute contraindication for prescribing OCP&;s is: (A) Diabetes, (B) Hypeension, (C) Obesity, (D) Impaired liver function
Answer is D. OCP act by - causing atropic changes of endometrium preventing nidation - Thickening cervical mucus - Increasing the tubal motility. The hormones of the OCP are metabolized in the liver. Hence, chronic liver diseases and liver failure are absolute CI of OCP.