A patient with cirrhosis of liver has the following coagulation parameters, Platelet count 2,00,000, Prothrombin time 25s/12s, Activated paial thromboplastin time 60s/35s, thrombin time 15s/ 15s. In this patient-: (A) D-dimer will be normal, (B) Fibrinogen will be, (C) ATIII will be high, (D) Protein C will be elevated
Answer is A. Ans. is 'a' i.e., D-dimer will be normal Coagulation defects in severe liver disease Coagulation factors & platelets Platelet ---> Variably decreased Fibrinogen factor XI and factory XIII ---> Variably decreased Prothrombin, factor, VII, IX and X ---> Decreased Factor V ---> Usually decreased Factor VIIIC & Von willebrand's factor --> Usually increased Thrombin time Prothrombin time ---> Usually increased Paial thromboplastin time --> Increased Test for fibrinolvsis and fibrin degradation products Plasminogen a --Antiplamin ---> Variably decreased Fibrin degradation products --> Usually increased Plas min --> Variably increased D -- Dimer --> Usually normal Miscellaneous Antithrombin --> Variably decreased Protein C and Protein S Decreased