Vigabatrin acts by:: (A) GABA receptor inhibitor, (B) Glutamate receptor inhibitor, (C) GABA transaminase inhibitor, (D) GABA transport inhibitor
Answer is C. (Ref: Katzung, 14th ed. pg. 431-32)* VIGABATRIN is GABAergic drug acts by inhibiting enzyme GABA transaminase.* This enzyme inhibition causes increased level of GABA in the neuron.* Use:# DOC in infantile spasm + Tuberous sclerosis# Simple and complex partial seizure* Contraindicated in absence seizure, Myoclonic seizure, Pre-existing visual field defect.* Side effect: Visual field defect due to peripheral retinal atrophy, weight gain, amnesia* GABA uptake transport inhibitor: TIAGABINE