Therapeutic Index is:: (A) ED50/LD50, (B) LD50/ED50, (C) ED50-LD50, (D) ED50 XLD50
Answer is B. ref; KD Tripathi Pharmacology 7th edition (page no:55) The gap between the therapeutic effect DRC (Dose Response Curve)and the adverse effect DRC defines the safety margin or the therapeutic index of a drug. Therapeutic index =median lethal dose /median effective dose or LD 50 / ED 50