In Wilson disease, which of the following is seen?: (A) Low ceruloplasmin, high urine copper, (B) Low ceruloplasmin, low urine copper, (C) High ceruloplasmin, high urine copper, (D) High ceruloplasmin, low urine copper
Answer is A. Investigations in Wilson disease: serum ceruloplasmin - Decreased Urinary copper excretion (Normal <40 mg/day) is increased to >100 mg/day Serum free copper level may be elevated in early Wilson disease Hepatic copper content >250mg/g of dry liver weight Slit lamp examination: Kayser Fleischer Ring