Autosplenectomy occurs in:: (A) Thalassemia, (B) Sickle cell anemia, (C) HbH disease, (D) Hydrops fetalis
Answer is B. b. Sickle cell anemia(Ref: Nelson's 20/e p 2336, Ghai 8/e p 345)Patients of sickle cell anemia may undergo auto-splenectomyQ due to multiple infarcts in splenic artery, that causes spleen to be reduced to fibrous tissue (splenic atrophy spleen may become non-palpable).