Mechanism of action of Oseltamivir and Zanamivir is:-: (A) DNA polymerase inhibition, (B) Inhibition of viral mRNA, (C) Blocking viral uncoating, (D) Neuraminidase inhibition
Answer is D. Oseltamivir acts by inhibiting influenza virus neuraminidase enzyme which is needed for release of progeny virions from the infected cell. Other neuraminidase inhibitor includes Zanamivir & Peramivir. These are used against Flu Virus (Bird flu/swine Flu). Drugs like Amantadine and Rimantadine are viral uncoating inhibitors. Route of administration of neuraminidase inhibitors in influenza: Zanamivir: Inhalational Oseltamivir: Oral Peramivir: Intravenous