Mechanism of action of maraviroc:: (A) Cyt P 450 inhibitor, (B) GP 41 inhibitor, (C) CCR5 inhibitor, (D) GP 120 inhibitor
Answer is C. Ans. (c) CCR5 inhibitorRef: Mosby drug reference for health professionals 2015 ed / 996* Maraviroc is an anti HIV drug which comes under fusion inhibitor category.* This drug binds to the receptor and inhibits the fusion stage of virus and hence inhibits their speed of replication.* There are two types of fusion inhibitors:Drugs which bind to CCR5 receptorDrugs which bind to GP 41 receptorMaraviroc: active against CCR5 tropic virus.Enfuvirtide: prevents entry of virus into host cell.Can be given orally.Can only be given in s.c. injection form.