Roopa Devi, a 65-year-old female with ovarian cancer is being treated with cisplatin-based chemotherapy. All of the following are used to limit the toxicityof cisplatin except:: (A) N-acetylcysteine, (B) Slow rate of infusion, (C) Chloride diuresis, (D) Amifostine
Answer is A. (Ref: Harrison 18th/697) N-acetylcysteine is used for paracetamol poisoining whereas slow intravenous infusion and chloride dieresis along with amifostine can limit cisplatin induced nephrotoxicity.