C- peptide is seen:-: (A) In pre-proinsulin, (B) In Proinsulin, (C) As a combined entity with insulin after secretion, (D) As a gastrointestinal proactive molecule
Answer is B. - Insulin is synthesized in BETA- cells of pancreas by usual cell machinery for protein synthesis. - Beginning with translation of insulin RNA by ribosomes attached to E.R to form pre proinsulin. - Pre proinsulin is cleaved in E.R to form pro-insulin. - Insulin & C peptide are packaged in secretory granules & secreted in equimolar amounts. - So, c - peptide levels can be measured by radioimmunoassay in insulin-treated diabetic patients to determine how much of their own natural insulin they are still producing