Characteristic of mixed connective-tissue disease are all of the following except: March 2005: (A) Hypogammaglobulinemia, (B) Membranous glomerulonephritis, (C) Polyahritis, (D) CNS involvement
Answer is A. Ans. A: Hypogammaglobulinemia Manifestations of mixed connective-tissue disease (MCTD) can be variable. Most patients experience Raynaud phenomenon, ahralgia/ahritis, swollen hands, sclerodactyly or acrosclerosis, and mild myositis. The following may be revealed by history or physical examination: Raynaud phenomenon Ahralgia/ ahritis Esophageal hypomotility Pulmonary dysfunction Swollen hands Myositis Rash Leukopenia Sclerodactyly Pleuritis/ pericarditis Pulmonary hypeension Membranous glomerulonephritis Lab investigations shows features of inflammation with elevated ESR and hypergammaglobulinemia