In Hereditary spherocytosis an inherited abnormality is seen in which of the following red blood cell component-: (A) A-globin chain, (B) a-globin chain, (C) Phosphatidylinositol glycan A, (D) Spectrin
Answer is D. HS is caused pathogenic mutations that affect ankyrin , band 3, spectrin , or band 4.2. Which causes insufficiency of membrane skeletal components. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:633