All of the following statements are true regarding ondansetron except:-: (A) It is antiemetic of choice for chemotherapy induced vomiting, (B) It is a 5-HT3 receptor antagonist, (C) It has significant drug interactions, (D) It may possess 5-HT4 agonism
Answer is C. ONDANSETRON Main mechanism of action of ondansetron is 5HT3 antagonism. It has minor 5HT 4 agonist action which is clinically insignificant. It does not block dopaminergic receptors. It is drug of choice for chemotherapy induced vomiting, radiation induced vomiting and post-operative vomiting. No clinically significant drug interactions have been noted with ondansetron