Sirolimus is more likely than cyclosporine to cause:: (A) Hypeension, (B) Osteoporosis, (C) Renal insufficiency, (D) Thrombocytopenia
Answer is D. (Ref: KDT 6/e p840) Cyclosporine and tacrolimus cause nephrotoxicity as an adverse effect. Sirolimus (rapamycin) results in bone marrow suppression and thus may cause anemia, thrombocytopenia and leukopenia.