Treatment with herceptin in breast cancer is indicated for: (A) ER receptor +ve tumours, (B) PR receptor +ve tumours, (C) K : 67 stain +ve tumours, (D) Tumours with over-expressed C-erb B-2 protein
Answer is D. Treatment with herceptin in breast cancer is indicated for Tumours with over-expressed C-erb B-2 protein it is a inhibitor of C-erb B-2 protein, which is a growth factor receptor also known as Transtuzumab it is currently approved by FDA for use only in metastatic disease ref ;(page no;551) 5th edition of SRB&;S Manual of SURGERY