Which one of the following ultrasound marker is associated with greatest increased risk for Trisomy 21 in fetus: (A) Echogenic foci in heart, (B) Hyperechogenic bowel, (C) Choroid plexus cysts, (D) Nuchal edema
Answer is D. (D) Nuchal edemaINCIDENCE OF MAJOR & MINOR DEFECTS/MA Trisomy 21NormalLikelihood ratio for isolated marker* Nuchal Fold33.5%0.6%9.8* Short humerus33.4%1.5%4.1* Short femur41.4%5.2%1.6* Hydronephrosis17.6%2.6%1.0* Echogenic focus in heart28.2%4.4%1.1* Echogenic bowel13.3%0.6%3.0* Major defect21.4%0.65%5.2