In amyloidosis, the following appearance will be seen in: (A) X-ray crystallography, (B) Electron microscope, (C) Spiral electron microscope, (D) Congo red stain
Answer is A. X-ray crystallography and infrared spectroscopy demonstrate a characteristic cross-b-pleated sheet conformation.This confirmation is seen regardless of the clinical setting or chemical composition and is responsible for the distinctive Congo red staining and birefringence of amyloid.By electron microscopy, all types of amyloid consist of continuous, nonbranching fibrils with a diameter of approximately 7.5 to 10 nm.Ref: Robbins Pathology; 9th edition; Page no: 257