Limited cutaneous systemic sclerosis have the following characteristic autoantibody positivity:: (A) Anti Topoisomerase I, (B) Anti-RNA polymerase III, (C) Scl-70, (D) Anticentromere
Answer is D. Subset of systemic sclerosis limited cutaneous scleroderma has the following features: Skin involvement-Indolent onset and progression. Limited to fingers. Raynaud's phenomenon-Precedes skin involvement; associated with critical ischemia Pulmonary aery hypeension-Frequent, late, may be isolated Pulmonary fibrosis - rare scleroderma renal crisis-Very rare Calcinosis cutis-Frequent, prominent Characteristic autoantibodies-Anti Centromere In Diffuse systemic sclerosis Characteristic autoantibodies-Anti Topoisomerase I (Scl-70), anti-RNA polymerase III Ref: Harrison, E-18, P- 2758.