True about RIBOZYME: (AllMS Nov 2013, Nov 2012): (A) Peptidyl transferase activity, (B) Cut DNA at specific site, (C) Participate in DNA synthesis, (D) GTPase activity
Answer is A. Ans. a. Peptidyl transferase activity (Ref: Harper 28/e p363; 27/e p364; Lippincott 4/435-439, Lehninger 5/e p1078)Ribozymes are RNA molecule with catalytic activityQ. Ribozymes play a central role in peptide bond formation (peptidyl transferase activity).RibozymeRibozymes are RNA molecules with catalytic activityQ.These generally involve transesterification reactions, and most are concerned with RNA metabolism (splicing and endoribonuclease).Recently, a ribosomal RNA component was noted to hydrolyze an aminoacyl ester and thus play a central role in peptide bond formation (peptidyl transferase)Q.