Mechanism of action of Triazoles: (A) Inhibits cell wall synthesis, (B) Inhibits ergosterol biosynthesis, (C) Inhibits glucan synthesis, (D) Inhibits tubulin
Answer is B. * Triazole antifungals (Fluconazole, Itraconazole, Voriconazole, Posaconazole) inhibit 14-sterol demethylase --> impair the biosynthesis of ergosterol--> resulting in depletion of membrane ergosterol along with accumulation of the toxic product 14-methyl-3,6- diol --> leading to fungal growth arrest. Ref:- Goodman & Gilman Pharmacological Basis of Therapeutics 13th Ed; Pg num:- 1091