True about drug induced SLE is:: (A) CNS manifestation are common, (B) Renal involvement is common, (C) Antihistone antibodies are found in many, (D) All with antibodies progress to lupus
Answer is C. C i.e. Antihistone antibodies are found Drug induced lupus is caused by procainamide, hydralazine, isoniazid (but not chloroquine) Q. It is a syndrome of positive ANA associated commonly with antihistone antibodies, fever, malaise, ahritis or intense ahralgiaVmyalgias, serositis, and/or rashQ. It occurs predominantly in whites, has less female predilection than SLE, rarely involves brain or kidneys, is rarely a/w anti ds DNA and usually resolves over several weeks after discontinuation of offending drugQ.