Antidote in Atropine poisoning is -: (A) Flumazenil, (B) Physostigmine, (C) Naloxone, (D) NaHCO3
Answer is B. Ans. is 'b' i.e., Physostigmine o Atropine blocks cholinergic receptors. o So, for atropine overdose, we require a drug that increases cholinergic action, o Physostigmine increases the concentration of Ach. o Physostigmine counteracts central (because it crosses BBB) as well as peripheral symptoms of atropine toxicity (other anticholinesterases like neostigmine and pyridostigmine counteract only peripheral symptoms as they cannot cross BBB) - Physostigmine is the DOC.