Which of the following does not cross the cell membrane :: (A) Glucose-6-phosphate, (B) Glucose, (C) Nitrous oxide, (D) Carbon monoxide
Answer is A. A i.e. Glucose-6-phosphate Glucose-6-phosphate cannot cross the cell membrane unless it in conveed into Glucose by the enzyme - Glucose-6-phosphatase.QVon Gerkes disease in deficiency of Glucose-6-phosphatase leads to accumulation of glucose-6-phosphate (and hence glycogen in the liver). In the absence of this enzyme, glucose-6-phosphate is not conveed into glucose and thus cannot enter the blood leading to hypoglycemia.