In thromboasthenia there is a defect in ?: (A) Platelet aggregation, (B) Platelet adhesion, (C) Decreased ADP release, (D) Desordered platelet secretion
Answer is A. Ans. is 'a' i.e., Platelet aggregation Platelet adhesion o Platelet adhesion referes to the binding of platelets to subendothelial matrix. o Platelet membrane glycoprotein Ib-IX is essential for platelet adhesion to subendothelial matrix. Platelet aggregation Platelet aggregation referres to adherence of platelets to one another. Platelet membrane glycoprotein IM-11.1a helps in aggregation. Congenital dysfunction of platelet Bernard-soulier syndrome o Defect in platelet adhesion due to inherited deficiency of glycoprotein lb-IX. Glanzmann's thrombasthenia o Defect in platelet aggregation due to inherited deficiency of glycoprotein