Calculate the loading dose of a drug whose systemic bioavailability will be 20%, Vd-200L and target concentration is 5gm/L: (A) 1g, (B) 5g, (C) 12.5g, (D) 25g
Answer is B. In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose Loading dose-= 1000/20=5 Ref: KD tripathi 8th ed