Thrombomodulin-thrombin complex produces its anticoagulant effect by-: (A) Inactivating factor V and VIII, (B) Inactivating protein C, (C) Inactivating protein S, (D) Inactivating factor VIII
Answer is A. Thrombomodulin Present on the endothelial cells and binds to thrombin and activates protein C, which inhibits clotting by proteolysis of factor Va and VIIIa. Ref: RAM DAS NAYAK 2nd Ed. Pg 89