LE cell is seen in ?: (A) Lupus erythmatosus, (B) Lupus vulgaris, (C) HNPCC, (D) Medullary carcinoma of thyroid
Answer is A. Ans. is 'a' i.e., Lupus erythematousus In SLE, antinuclear antibodies (AN Ps) can not penetrate intact cells. However, nuclei are exposed, ANA can bind to them. In tissues, nuclei of damaged cells react with ANAs, lose their chromatin pattern, and become homogeneous, to produce lupus - erythematous (LE) bodies or hemotoxylin bodies. When these LE bodies are engulfed by phagocytic cells (neutrophil or macrophage/monocyte), the phagocytic cells are called LE cells.