An adverse effect of neuroleptic drugs is directly correlated positively to the antipsychotic potency of the different compounds. Which of the following is it?: (A) Sedation, (B) Extrapyramidal motor disturbances, (C) Postural hypotension, (D) Lowering of seizure threshold
Answer is B. (Ref: KDT 6/e p426, 431) Antipsychotic potency of typical antipsychotic drugs is related to their D2 receptor blocking action. D2 blocking action is also responsible for extrapyramidal adverse effects like muscle dystonia and Parkinsonism etc.