All of the following factor increase the risk of amino glycoside renal toxicity except -: (A) Elderly person, (B) Hypokalemia, (C) Simultaneous use with penicillin, (D) Aminoglycoside administration in recent past
Answer is C. Ans. is 'c' i.e., Simultaneous use with penicillin Nephrotoxicitv of aminoglycosides is potentiated by Advanced age, liver disease, diabetes mellitus, septic shock. Drugs - Amphotericin B, cyclosporine, vancomycin, ACE inhibitors, cisplatin. Longer course of therapy. Furosemide potentiates nephrotoxicity by causing volume depletion and hypokalemia.