The best investigation for the diagnosis of amyloidosis is:: (A) Colonoscopy, (B) Rectal biopsy, (C) Upper GI endoscopy, (D) CT scan
Answer is B. The histological examination of the biopsy material is the commonest and confirmatory method for the diagnosis in a suspected case of amyloidosis. The sites for the biopsy can be:- Renal tissue Rectum Abdominal fat aspiration Gingiva. The rectum Q is the best site for taking the biopsy in the options provided. However as per Harrison latest edition, the abdominal fat aspirate is currently the best option for systemic amyloidosis.