Regarding dihydroaemisinin pharmacokinetics, all are true except:-: (A) Dose adjustment is not required in hepatic or renal failure, (B) Has a long half life, (C) Oral bioavailability is around 30%, (D) Autoinduction of metabolism
Answer is B. Dihydroaemisinin * It has potent schizontocidal action.* These drugs are lethal to early malarial gametes but not mature ones.* They do not kill vivax hypnozoites* The duration of action is sho and recrudescence rate is high.* Dose adjustment is not required in hepatic or renal failure.* Oral bioavailability is around 30%* Auto induction of metabolism.