which of the following drug binds only with the aniotic site of cholinesterase?: (A) Physostigmine, (B) Neostigmine, (C) Edrophonium, (D) Pyridostigmine
Answer is C. Ref:KD Tripathi pharmacology 7th edition (page.no: 105) Edrophonium and Tacrine attach only to the anionic site and don't form a covalent bond with the enzyme. so, edrophonium is a very sho-acting drug. While organophosphates attach only to the esteratic site forming a covalent bond. Carbamates (physostigmine, pyridostigmine, neostigmine) carbamylate the esteratic site of the enzyme