True about minimal change disease is:: (A) Peak incidence is between 2-4 years of age, (B) Renal failure is usually present in adolescent, (C) Steroids are not effective medications for treatment., (D) It is characterized by selective proteinuria
Answer is A. Ans. A. Peak incidence is between 2- 4 years of ageIn minimal change nephrotic syndrome (MCNS) (approximately 80% of total cases of nephrotic syndrome in children), the glomeruli appear normal or show a minimal increase in mesangial cells and matrix.Findings on immunofluorescence microscopy are typically negative, and electron microscopy simply reveals effacement of the epithelial cell foot processes. More than 95% of children with minimal change disease respond to corticosteroid therapy.A diagnosis other than MCNS should be considered in children <1 yr of age, with a positive family history of nephrotic syndrome, and/or the presence of extrarenal findings (e.g., arthritis, rash, anemia), hypertension or pulmonary edema, acute or chronic renal insufficiency, and gross hematuria.