Treatment of Hormone dependent fungating carcinoma of breast with secondaries in the lung in a female patient aged 30 years is: (A) Simple mastectomy followed by oophorectomy, (B) Radical mastectomy followed by oophorectomy, (C) Adrenalectomy, (D) Lumpectomy followed by castration
Answer is A. Hormonal therapy in Carcinoma Breast Ovarian suppression or ablation Bilateral oophorectomy. Medically by LHRH agonist (Goserelin, leuprolide) SERM: Tamoxifen and Raloxifen Aromatase Inhibitors Non-steroidal : Letrozole & Anastrazole Steroidal : Exmestane Anti-Estrogens Fulvestrant Progestins Megesterol & Medroxyprogesterone acetate Ref: schwaz's principle of surgery 10th edition Pgno : 552-553