True about Laron dwarfism is:: (A) Growth hormone deficiency, (B) Growth hormone insensitivity, (C) Plasma IGF-1 is markedly increased, (D) Plasma IGF-BP3 at normal levels
Answer is B. Laron dwarfism, Plasma GH is normal or elevated GH receptors are unresponsive as a result of loss-of-function mutations of the gene for the receptors. Resultsin growth hormone insensitivity. Plasma IGF-I is markedly reduced, along with IGFBP 3 (IGF-binding protein-3)