In genetic deficiency of MPO the increased susceptibility to infection is due to -: (A) Defective production of Prostaglandins, (B) Defective rolling of neutrophils, (C) Inability to produce hydroxyl-halide radicals, (D) Inability to produce hydrogen peroxide
Answer is C. Myeloperoxidase is an enzyme in Macrophages for production of hypochlorous radical from H2O2, which kills bacteria. Basic Pathology, Robbins. Page no.: 38