Microdeletion leading to instability of DNA, causing the cell to undergo degeneration is seen as a marker in which of the following cancer?: (A) Medullary carcinoma of thyroid, (B) Small cell lung cancer, (C) Gastric lymphoma, (D) Colon carcinoma
Answer is D. Microsatellite instability is due to impaired DNA missmatch repair. It is associated with many malignancies but colon cancer has highest association.