Inactivation of coisol into coisone occurs mainly in which organ?: (A) Lungs, (B) Liver, (C) Adrenals, (D) Kidney
Answer is D. Coisol is inactivated to coisone by microsomal enzyme 11b-hydroxysteroid dehydrogenase type II This enzyme is mainly in the kidney. Other organs involved in this activity are colon, salivary glands and other target tissues.