Febrile response in CNS is mediated by?: (A) Bacterial toxin, (B) IL-1, (C) IL-6, (D) All
Answer is D. Ans. is 'a' i.e., Bacterial toxin; 'b' i.e., IL-1; 'c' i.e., IL-6 Pyrogenes Pyrogenes are substances that cause fever. Pyrogens may be exogenous or endogenous Exogenous --> Bacterial toxins Endogenous --> IL-1, TNF-a, IL-6, Interferons, Ciliory's neurotropic factor These pyrogenes increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set point and causes fever.