Most common cause of nephrotic range proteinuria in an adult is-: (A) Diabetes Mellitus, (B) Amyloidosis, (C) Hypeensive nephropathy, (D) Wegner'sGranulomatosis
Answer is A. Most common cause of nephrotic syndrome in Elderly people -membranous glomerulonephritis(membranous nephropathy). Children-minimal change disease Most common cause of chronic renal failure is DIABETIC NEPHROPATHY . Pathological changes seen -mesangial sclerosis ,eosinophilic PAS +nodules called -kimmelsteil wilson nodules Immunofluorescence-non specific deposition of IgG and complement. On Electron microscopy-no immune deposits are seen. Earliest manifestation of DN-microalbuminuria(30-300 mg/24 hrs) In advanced DN, kidneys are enlarged in contrast to many other Glomerular diseases where kidneys decrease in size. Ref:Harrison 20 th edition pg no. 2144