Brinzolamide is: (A) Competitive and reversible carbonic anhydrase inhibitor, (B) Non-competitive and reversible carbonic anhydrase inhibitor, (C) Competitive and irreversible carbonic anhydrase inhibitor, (D) Non-competitive and irreversible carbonic anhydrase inhibitor
Answer is B. Carbonic anhydrase (CAse) is an enzyme which catalyses the reversible reaction H2O + CO2 - H2C03 Hence, Carbonic anhydrase functions in CO2 and HC03 transpo and in H+ ion secretion. Carbonic anhydrase inhibitors act by non-competitive but reversible inhibition of the enzyme -Decreases the production of aqueous humor from ciliary body epithelium. Ex: Acetazolamide, dorzolamide and Brinzolamide.