Regarding termination of drug action:: (A) Drugs must be excreted from the body to terminate their action, (B) Metabolism of drugs always abolishes their pharmacologic activity, (C) Hepatic metabolism and renal excretion are the two most important mechanisms involved, (D) Distribution of a drug out of blood stream terminates the drug's effects
Answer is C. - Drug action may be terminated either by liver metabolism or by renal excretion. It is not necessary to be excreted from the body.
- By metabolism of the drug, most drugs will be inactivated, but some may be activated.
- Some drugs give their action after distribution into the tissues.