The persistent suppression of bacterial growth that may occur after limited exposure to some antimicrobial drug is called :: (A) Time dependent killing, (B) Post antibiotic effect, (C) Concentration dependent killing, (D) Sequential blockade
Answer is B. Time dependent killing kinetics is shown by aminoglycosides. Here, the killing activity depends upon the length of time, plasma concentration is above MIC.
Concentration dependent killing is shown by β lactam drugs. Here, killing activity depends upon the ratio of plasma concentration to MIC.
Post-antibiotic effect is the suppression of bacterial growth after limited exposure to the antibiotic.