Lesions of which of the hypothalamic nuclei cause diabetes insipidus:: (A) Dorsomedial nuclei, (B) Supraoptic and paraventricular nuclei, (C) Median preoptic nuclei, (D) Ventromedial nuclei
Answer is B. b. Supraoptic and paraventricular nuclei(Ref: Nelson's 20/e p 348-349, Ghai 8/e p 511)Vasopressin, a 9-amino-acid peptide, has both antidiuretic and vascular pressor activity and is synthesized in the paraventricular and supraoptic nuclei of the hypothalamus.Deficiency of Vasopressin is responsible for Diabetes insipidus.