Endogenous pyrogens act by ?: (A) Increasing heat generation, (B) Raising thermostat point of hypothalamus, (C) Causing vasoconstriction, (D) By Non-shivering thermogenesis
Answer is B. Ans. is 'b' i.e., Raising thermostat point of hypothalamusBacterial toxins (exogenous pyrogens) stimulate inflammatory cells to secrete pyrogenic cytokines (endogenous pyrogens), e.g. IL-I, TNF-a , and IL-6.These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever.