Anaphylactic reaction caused by NSAIDs, all are true, except ?: (A) Caused by All NSAIDs, (B) COX-2 inhibitors are safe, (C) Related to hypersensitivity reaction, (D) Not related to inhibition of COX
Answer is B. Ans. is 'b' i.e., COX-2 inhibitors are safe(Ref: Clinical pharmacology 3d/e p.786)Anaphylactic reaction (anaphylaxis)It is dre to immediate (type-L) hypersensitivity involving cross linking of drug-specific IgE.Regardless of COX selectivity pattern, NSAIDs may function as haptens capable of inducing allergic sensitization.Thus, all COX inhibitors (nonselective or selective) can cause this reaction.