A patient with known mutation in the `RB gene' is `disease free' from Retinoblastoma. The patient is at highest risk of developing which of the following malignancies –: (A) Renal cell carcinoma, (B) Osteosarcoma, (C) Pinealoblastoma, (D) Chondrosarcoma
Answer is B. Most common secondary tumor in survivors of retinoblastoma is osteosarcoma.