Regarding obesity syndromes, determine the true / false statements: a) Prader-Willi syndrome has normal stature with truncal obesity b) Laurence-Moon-Biedl is autosomal; polydactyly is seen c) Ahlstrom's syndrome patients has moderate mental retardation d) Cohen's syndrome- Patients will have craniofacial anomalies and delayed pubey e) Carpenter's syndrome have secondary hypogonadism: (A) b,d,e-True & a, c- False, (B) a,c,d,e-True & b- False, (C) b,c,d,e-True & a- False, (D) b,c,d-True & a,e- False
Answer is A. Prader-Willi syndrome is sporadic inheritance, sho statured with generalised obesity. Primary gonadism and moderate mental retardation is seen. Ahlstrom's patients will have normal intelligence. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 626 Table 77-2 A Comparison of Syndromes of Obesity--Hypogonadism and Mental Retardation.