Ram Devi presented with generalized edema sweating and flushing tachycardia and fever after bee sting. This is :: (A) T cell mediated cytotoxicity, (B) IgE mediated reaction, (C) IgG mediated reaction, (D) IgA mediated hypersensitivity reaction
Answer is B. Ans. is 'b' i.e. IgE mediated reaction The symptoms of the patient are d/t hypersensitivity type I reaction Type I is mediated by IgE and it flairs up within minutes.The symptoms range from rashes to anaphylactic shock with vasodilatory hypotension and bronchiolar spasm.Examples of type IEczema*Hay fever*Asthma*Anaphylactic shock*Urticaria*A cute dermatitis *Theobald Smith reaction *Other hypersensitivity reactionsType IIis characterized by an antigen antibody reaction on the surface of a host cell*.Mediated by IgG or IgM.ExamplesBlood transfusion reactions *Transplant rejection *Auto immune hemolytic anaemia*Auto immune thrombocytopenic purpura *Diabetes disease*Good pasture's syndrome *Grave's disease*Myasthenia gravis*PemphigusPernicious anaemia*Rheumatic fever*Type HI reactionsMediated by antigen / antibody complex*.ExamplesPAN*Post streptococcal glomerulonephritis*Rheumatoid arthritis*Systemic lupus erythematosis*Acute viral hepatitis*Penicillamine toxicity*Serum sickness*Arthus reaction*Type IV reactionCell mediated reaction (delayed hypersensitivity)*.ExamplesTuberculosis*Sarcoidosis*Temporal arteritisContact dermatitis* (not that acute dermatitis in type I)Lepromin test*Patch test*PPD*