JAK-STAT kinase receptors is associated with ?: (A) T cAMP, (B) IP3 - DAG, (C) Ion channels, (D) Nuclear transcription
Answer is D. Ans. is'd'i.e., Nuclear transcriptionJAK-STAT-Kinase binding receptors:These receptors differ in not having intracellular enzymatic action on receptor itself. Agonist binding induces interaction of these receptors with free intracellular tyrosine kinase - Janus kinase (JAK).jAK phosphorylates activators of transcription (STAT), which then regulate the nucleus transcription resulting in a biological response.Examples -+ Growth hormone, Prolactin,