Which of the following is not a poor prognostic factor in neuroblastoma?: (A) MYCN amplification, (B) High mitosis-karyorrhexis index, (C) Evidence of gangliocytic differentiation, (D) Mutations of neuritogenesis genes
Answer is C. Unourable prognostic factors in neuroblastoma: Stage 3, 4 Age >18 months Absence of evidence of schwannian stroma and gangliocytic differentiation High Mitosis-karyorrhexis index (>200/5000 cells) Near-diploid (segmental chromosome losses; chromothripsis) MYCN Amplified Chromosome 1p loss Chromosome 11q loss Absent TRKA expression Presence of TRKB expression Mutations of neuritogenesis genes