Characteristic feature of Goodpasture's syndrome?: (A) Lumpy-bumpy deposits on immunofluorescence, (B) Serum antibodies against alpha 3 NC 1 domain of collagen-IV, (C) Serum antibodies against alpha 1 NC 1 domain of collagen III, (D) Anti DNAse antibodies positive
Answer is B. In Goodpasture syndrome, type 1 RPGN & type II hypersensitivity reaction are seen. It is characterized by serum antibodies against alpha 3 NC1 domain of collagen - IV. Lumpy-bumpy deposits on immunofluorescence- seen in Post Streptococcal GN