Bisphosphonates act by: (A) Increasing the osteoid formation, (B) Increasing the mineralization of osteoid, (C) Decreasing the osteoclast mediated resorption of bone, (D) Decreasing the parathyroid hormone secretion
Answer is C. Bisphosphonates (BPNs) are analogues of pyrophosphate: carbon atom replacing oxygen in the P-0-P skeleton. They inhibit bone resorption by inhibiting osteoclast function- useful to prevent osteoporosis in addition to metabolic bone diseases and hypercalcaemia. (REF.Essentials of Pharmacology TD TRIPATHI 6th EDITION page no 333)