An HIV positive, 36 years old female on ART needs counseling. Which of the following 1st trimester markers of Down syndrome would be affected by HIV:: (A) b-hCG, (B) PAPP-A, (C) NT, (D) All of the above
Answer is A. Ans. is a, i.e. b-hCGRef. Fernando Arias 4/e, p 4In women with HIV:b-hCG levels in women who are HIV positive and are on treatment have been shown to have a lower value than women without HIV and those with HIV not receiving treatment. In contrast PAPP- A levels and NT are not affected by HIV status.