Which one of the following statements about biguanides is not true -: (A) Don't stimulate insulin release, (B) Don't stimulate insulin release, (C) Renal Dysfunction is not a contraindication for their use, (D) Renal Dysfunction is not a contraindication for their use
Answer is C. Ans. is 'c' i.e., Renal dysfunction is not a contraindication for their use o Biguanides are contraindicated in hypotensive states, cardiovascular, respiratory, hepatic and renal disease and in alcoholics because of increased risk of lactic acidosis. About other options o Biguanides do not cause insulin release. o Their major action is to suppress hepatic gluconcogenesis (Decreased hepatic glucose production). o Biguanides may be combined with sulfonylureas and thiazolidinediones in type 2 DM in whom oral monotherapy is ineffective.