In a patient suffering from chronic myeloid leukemia, Hb falls from llg% to 4g% in a sho span of time, and splenomegaly occurs. The cause could be -: (A) Accelerated phase, (B) CML in blast crisis, (C) Ineffective erythropoiesis, (D) Myelofibrosis
Answer is A. <p>Accelerated phase of CML is defined as increasing degree of anemia ,blast count in blood or marrow between 10-20% ,marrow basophils 20% or more ,platelet ciunt falling below 1,00,000/microlitre.An accelerated phasecof CML is characterised by progressively rising leucocytosis associated with thrombocytosis or thrombocytopenia & splenomegaly. </p><p>Reference :Harsh mohan textbook of pathology sixth edition pg no 358</p>