The peripheral blood smear of a patient shows features of thalasemia, also presented with anaemia. Family history is also +ve. The investigation done to establish the diagnosis is -: (A) ESR estimation, (B) Blood spherocyte estimation, (C) Bone marrow aspiration, (D) Hb-electrophoresis
Answer is D. Ans. is d i.e., Hb - Electrophoresis o Hemoglobin electrophoresis should always be the first investigation to include/exclude the diagnosis of thalasemia. o The level of normal adult hemoglobin HbA is markedly decreased with propoionate increase in HbA2 and HbF. X-ray findings in thalassemia Crew cut appearance Hair on end appearance