Sensitivity of chemoreceptors in COPD: (A) Decreased to H+, (B) Increased to H+, (C) Increased to PCO2, (D) Increased to PO2
Answer is C. The main chemoreceptors involved in respiratory feedback are: Central chemoreceptors: These are located on the ventrolateral surface of medulla oblongata and detect changes in the pH of spinal fluid. They can be desensitized over time from chronic hypoxia (oxygen deficiency) and increased carbon dioxide Ref: guyton and hall textbook of medical physiology 12 edition page number:365,366,367