Raju, a 10 yr old child, presents with a predisposition to fractures, anaemia, hepatosplenomegaly and a diffusely increased radiographic density of bones. The most likely diagnosis is -: (A) Osteogensis imperfecta, (B) Pyknodysostosis, (C) Myelofibrosis, (D) Osteopetrosis
Answer is D. Osteopetrosis is characterized by progressive anemia, hepatosplenomegaly, severe infections, pathological fractures and diffusely sclerotic bone.