Hypeension with androgenisation of a female child is a feature of congenital adrenal hyperplasia due to deficiency of-: (A) C-21 hydroxylase, (B) C-11 hydroxylase, (C) C-17 hydroxylase, (D) Desmolaie
Answer is B. with hypeensive form of CAH due to CYP11B1 deficiency, 11- delay coicosterone and 11- deoxycoisol accumulate. Diagnosis confirmed by demonstrating increased levels of 11- deoxycoisol in blood ( Harrison 17 pg 2267)