Crohn's disease is associated with:: (A) NOD-2/CARD-15 gene, (B) P53 suppressor gene, (C) Philadelphia chromosomes, (D) BRCA-1 gene
Answer is A. Etiology : Unknown Infectious agents proposed as potential causes: Mycobacterium paratuberculosis and measles virus IBD-1 (chromosome 16q) Relatively specific for Crohn's disease IBD-2 (chromosome 12q) More common in Ulcerative colitis on 16q CARD-15/NOD2 mutation lead to CD