All of the following are seen in follicular carcinoma of thryoid, except:: (A) PAX8-PPARG fusion, (B) RAS gene mutations, (C) Point mutations of TP53, (D) Loss-of-function mutations of PTEN gene
Answer is C. Genetics of follicular thyroid carcinomas: 30% to 50% of follicular carcinomas harbor RAS mutation. 20% to 50% of follicular carcinomas harbor PAX8-PPARG fusion. Up to 10% of follicular carcinomas exhibit gain-of-function mutations of PIK3CA (the gene that encodes phosphoinositide 3-kinase ) or loss-of-function mutations of PTEN, a tumor suppressor gene and negative regulator of PI3K pathway. Point mutations of TP53, beta-catenin (CTNNB1), and TE are seen in poorly differentiated and anaplastic carcinomas.