HPV causes which change in cervical epithelium ?: (A) Induction of apoptosis, (B) Induction of necrosis, (C) Immoalization of epithelial cells, (D) By stimulating telomerase
Answer is C. Ans. is 'c' i.e., Immoalization of epithelial cells HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia.Products of E-genes (E6, E7) are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively.