Most common cause of congenital adrenal hyperplasia?: (A) 17- Hydroxylase deficiency, (B) 11- Hydroxylase deficiency, (C) 21- Hydroxylase deficiency, (D) 16- Hydroxylase deficiency
Answer is C. Ans. c (21- Hydroxylase deficiency). (Ref. Harrison, Principles of Medicine, 18th/2178)Congenital adrenal hyperplasia (CAH)Features3-beta-OH21-OH11-beta-OH17-alpha-OH1. Salt loss++ 2. Hypertension -++3. Virilization-++-4. Ambigous genitaliaa) Male+__+b) Female+++-Note: 21-hydroxylase deficiency is the most common type of CAH