All are true bout Oral anticoagulants EXCEPT:: (A) Acts in vivo, (B) Acts both in vivo and in vitro, (C) Interferes with synthesis of Vit K, (D) Causes Hematuria
Answer is B. Ans. (b) Acts both in vivo and in vitro* ORAL ANTICOAGULANT is warfarin. It is used only in vivo (body), NOT in vitro (lab).* Warfarin is not used to store blood.* It acts by inhibiting Vitamin K. Due to overdose, hematuria is the First manifestation noted.* Dose monitoring is done by INR.* Antidote of warfarin overdose: Vitamin KPT (Prothrombin Time)aPTT (activated Partial Thromboplastin Time)* Assess activity of Extrinsic coagulation pathway* Used when on warfarin treatment* WePT: Warfarin for extrinsic; PT value assessed.* Assess activity of Extrinsic coagulation pathway.* Used while on heparin treatment.* HINT: Heparin for Intrinsic; aPTT value assessed.