A thalassemic patient with need of recurrent transfusion. But he develops transfusion reaction like fever and chills. What can be done to the blood to decrease the rate of transfusion reactions?: (A) Leucocyte depletion, (B) Antibiotics, (C) Irradiation, (D) Washed RBCs
Answer is A. In Leucocyte depletion- transfusion reaction d/t | WBC and cytokine that- come along with blood transfusion Filter- prevent WBC to enter in body of recipient So chances of transfusion reaction will be minimal. - This method is called leuco-depletion where we reduce the number of WBC going into the patient's body. - Leucodepletion can be done by Irradiation Filters - Option C- Irradiation can be the answer but however it is expensive, therefore can't be used routinely. - Option D- Triple washed RBCs was a method that was used earlier but was not very effective. Extra edge- Sudden onset development of symptoms such as back pain during transfusion indicates acute hemolytic transfusion reaction, First step includes immediate cessation of transfusion, followed by collection samples for testing.