All the following factors predispose to Aoic dissection , except: (A) Systemic hypeension, (B) Takayasu's aeritis, (C) 1 at trimester of pregnancy, (D) Marfan's syndrome
Answer is C. Ref Harrison 19 th ed pg 1541 Aoic dissection is the major cause of morbidity and moality in patients with Marfan's syndrome or Loeys- Dietz syndrome, and similarly may affect patients with Ehlers-Danlos syndrome. The incidence also is increased in patients with inflamma- tory aoitis (i.e., Takayasu's aeritis, giant cell aeritis), congenital aoic valve anomalies (e.g., bicuspid valve), coarctation of the aoa, and a history of aoic trauma. In addition, the risk of dissection is increased in otherwise normal women during the third trimester of pregnancy. Aoic dissection also may occur as a consequence of weight lifting, cocaine use, or deceleration injury.