In which of the following types of Carcinoma Breast, Comedo growth pattern in seen?: (A) Ductal carcinoma in situ, (B) Medullary carcinoma, (C) Lobular carcinoma in situ, (D) Infiltrating lobular carcinoma
Answer is A. Historically, ductal carcinoma in situ (intraductal carcinoma) has been divided into five architectural subtypes: comedocarcinoma, solid, cribriform, papillary and micropapillary. Comedocarcinoma is characterized by solid sheets of pleomorphic cells with high-grade nuclei and central necrosisThe necrotic cell membranes commonly calcify and are detected on mammography as clusters of linear and branching microcalcifications.