Which of the following viral markers signifies the ongoing viral replication in the case of Hepatitis-B infection?: (A) Anti-HBs, (B) Anti-HBc, (C) HBe Ag, (D) HBs Ag
Answer is C. HBeAg appearance- high levels of virus replication and reflects the presence of circulating intact virions and detectable HBV DNA. Patients with precore mutations cannot synthesize HBeAg In self-limited HBV infections, HBeAg becomes undetectable sholy after peak elevations in aminotransferase activity, before the disappearance of HBsAg, and anti-HBe then becomes detectable, coinciding with a period of relatively lower infectivity.