Large giant cells are found in -: (A) Alcoholic hepatitis, (B) Neonatal hepatitis, (C) Serum hepatitis, (D) Amoebic hepatitis
Answer is B. Ans. (b) Neonatal hepatitis(Ref: Robbins 9th/pg 857)The morphologic features of neonatal hepatitis include:Lobular disarray with focal liver cell apoptosis and necrosis QPanlobular giant-cell transformation of hepatocytes QProminent hepatocellular and canalicular cholestasisMild mononuclear infiltration of the portal areas,Reactive changes in Kupffer cellsExtramedullary hematopoiesis