Increased nuchal fold thickness is a feature of ?: (A) Paul-Bunnel syndrome, (B) De-pan syndrome, (C) Down's syndrome, (D) Cri-duchat syndrome
Answer is C. Ans. is 'c' i.e., Down's Syndrome Nuchal fold thickness is increased in Down syndrome. This feature is used in suspecting the diagnosis of Down's syndrome prenataly. Down's syndrome o Down's syndrome is due to trisomy 21. o Down's syndrome is the most common trisomy. o In this condition, extragenetic materia causes delay in the way a child develops and often leads to mental retardation. o In Down's syndrome the child gets on extra chromosome, he has total of 47 chromosome instead of 46 chromosome. o This is the extra genetic material that causes the physical and cognitive delays associated with Down's syndrome. o There is a well recognized association with advanced maternal age, the risk considerably increases in women > 35 years of age. o Advanced paternal age has no effect.