Appropriate therapy with antiretroviral agents results in a syndrome characterized by an increased inflammatory response from the recovered immune system to subclinical oppounistic infection. What is this syndrome called as?: (A) HIV related hyper- reactivity syndrome, (B) AIDS related inflammatory syndrome, (C) Immune reconstitution inflammatory syndrome, (D) CD4 responsive inflammatory syndrome
Answer is C. Immune reconstitution inflammatory syndrome (IRIS)- characterized by increased inflammatory response, subclinical oppounistic infections. common in patients with severe CD4 + T-lymphocyte depletion There is fever & worsening of clinical manifestations of oppounistic infection or new manifestations (e.g., enlargement of lymph nodes, pulmonary infiltrates), typically within the 1st few weeks after initiation of antiretroviral therapy.