Glyceryl trinitrate is given by sublingual route because of:: (A) Short t1/2 in plasma, (B) High hepatic first pass metabolism, (C) High bioavailability by oral route, (D) Extensive protein binding
Answer is B. Ans. (B) High hepatic first pass metabolism(Ref: KDT 8th/e p588)Main advantage of sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation.