Which of the following disease is more common in patients with alfa 1 antitrypsin deficiency?: (A) Good pasteurs syndrome, (B) Microscopic PAN, (C) Wegeners granulamatosis, (D) Churg -strauss syndrome
Answer is C. Alfa 1 antitrypsin is an inhibitor of proteinase 3. Antiproteinase antibodies are seen in Wegeners granulamatosis. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 2343