In Cicatricial pemphigoid, which antigen is bound by IgG on the epidermal side of the salt split skin technique?: (A) XVII collagen, (B) Epiligrin, (C) Laminin 5, (D) BP antigen 1 & 2
Answer is A. Majority cases of mucous membrane pemphigoid or cicatricial pemphigoid demonstrate IgG directed against antigens on the epidermal side of the salt-split skin, which have been identified as BP 180 or XVII collagen. The antigen present on the dermal side is epiligrin (laminin 5).