In giant cell tumor of the bone.,the cell of origin is: (A) Fibroblst cells, (B) Osteoclast and precursors, (C) Osteoblast and precursors, (D) Sinusoidal cells
Answer is C. The Neoplastic cells of giant cell tumor are primitive osteoblast precursors but they represent only a minority of the tumor cells.The bulk of the tumor consists of non Neoplastic osteoclast and their precursors Ref Robbins page no 1203