Knudsen's two hit hypothesis is for: (A) Glaucoma, (B) Retinoblastoma, (C) Optic glioma, (D) Meningioma
Answer is B. Knudson gave the hypothesis that there are two mutations needed for Retinoblastoma to manifest. Either both hits are on somatic cells or one is at the somatic cells and one is at germ cell. Respectively, it can be sporadic or a hereditary case Refer khurana 6/e p 303