GNAS mutation is associated with malignancy of: (A) Lactotrophs, (B) Somatotrophs, (C) Thyrotrophs, (D) Coicotrophs
Answer is B. GNAS encodes for alpha subunit of stimulatory G-protein , Gsalpha . Oncogenic activation of GNAS constitutively activates Gsalpha leading to Growth hormone(GH) adenomas. Ref: Robbins and cotrans 9e Pg 1076