Catecholamine hormones are synthesized in the:: (A) Chromaffin cells of adrenal medulla, (B) Zona glomerulosa of adrenal cortex, (C) Zona fasciculate of adrenal cortex, (D) Zona reticularis of adrenal cortex
Answer is A. Ans. A. Chromaffin cells of adrenal medullaCatecholamines are synthesized by tyrosine. DOPA forms Dopamine in the cytosol which by Dopamine oxidase (Cu containing) forms Nor-epinephrine in the Chromaffin granules of pheochromocyte. This reaction requires copper and Vitamin C. Nor-epinephrine then enters cytoplasm and undergoes methylation by methionine to form Epinephrine. Both after synthesis enters in the chromaffin granules for storage.