Biotin is used in the treatment of:: (A) Multiple carboxylase deficiency, (B) Keto acid dehydrogenase deficiency, (C) Transketolase deficiency, (D) Multiple dehydrogenase deficiency
Answer is A. Multiple carboxylase/biotinidase deficiency:- autosomal recessive disorder due to defect in holocarboxylase synthase or biotinidase deficiency. Clinical features:- -Metabolic ketoacidosis -Diffuse rash -Alopecia -Seizures -Intellectual disability