The activity of pyruvate carboxylase is dependent upon the positive allosteric effector: (A) Succinate, (B) AMP, (C) Isocitrate, (D) Acetyl Co A
Answer is D. Pyruvate carboxylase is an allosteric enzyme. Acetyl CoA is an activator of pyruvate carboxylase so the generation of oxaloacetate is ored when acetyl CoA level is sufficiently high.Ref: DM Vasudevan, 7th edition, page no: 120