Mechanism of action of cholera toxin is: (A) Ganglioside, (B) Adenyl cyclase, (C) Both 1 and 2, (D) Exotoxin
Answer is C. CHOLERA ENTEROTOXIN Light (L) toxin : Binds with ganglioside in epithelial cell membrane Heavy(H) toxin : Activates Adenyl cyclase in Epithelial cell wall which increase camp, leading to outpouring of isotonic fluid in lumen of intestine Ref: Park 25th edition Pgno : 253