All of the following are true about Sickle cell disease, Except:: (A) Single nucleotide change results in change of Glutamine to Valine, (B) RFLP results from a single base change, (C) 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residue, (D) HbS confers resistance against malaria in heterozygotes
Answer is C. C i.e. 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residueIn sickle cell anemia- Glutamic acid is replaced by valine at sixth position in /3 - globin chainQ.Sticky patch is generated as a result of replacement of polar residue (negatively charged glutamate amino acid) with a nonpolar hydrophobic residue (valine)Q. This change makes HbS (sickle cell hemoglobin) less soluble, when deoxygenated and cause sicklingQ.HbS confers resistance against malaria in heterozygotesQ.