What is the pathogenetic mechanism of HPV in causing cervical carcinoma?: (A) Down regulation of 16INK4 protein, (B) Degradation of cyclin D1, (C) Genomic instability of E6 and E7, (D) Up regulation of BCL2
Answer is C. Reference : Robbins basic pathology 9th edition : the oncogene city of HPV is related to the expression of two viral oncoproteins,E6 and E7 they bind to Rb and p53,respectively neutralizing their function