Following is not true about the gene mutations leading to breast carcinoma -: (A) Most common mutation in inherited breast carcinoma is BRCA1, (B) BRCA 1 mutation is present in most of the cases of breast carcinoma, (C) Inherited breast carcinomas make about 3 % of the total cases, (D) p53 mutation also increases chances of colon and brain cancer
Answer is B. Answer- B. BRCA 1 mutation is present in most of the cases of breast carcinomaGenetic mutations associated with breast cancer are of two types -i) Germline mutations (inherited mutations)Involved in familial cases of breast cancer.ii) Somatic mutations (acquired mutation)Involved in sporadic cases of breast cancer