Which of the following are the adverse effects of pioglitazone?: (A) Weight gain, (B) Hepatotoxicity, (C) Increased risk of urinary bladder cancer, (D) All of the above
Answer is D. Glitazones - They act by stimulating PPAR- g receptor - Reverse insulin resistance - e.g. Pioglitazone Pioglitazone: -Adverse effects: Hepatotoxic Sodium and water retention weight gain Increases risk of urinary bladder carcinoma Avoid in liver disease or hea failure -Rosiglitazone increases the risk of myocardial infarction -Troglitazone banned because it cause liver damage