There is mutation of gene coding for the ryanodine receptors in malignant hypehermia. Which of the following statements best explains the increased hea production in malignant hypehermia: (A) Increased muscle metabolism by excess of calcium ions, (B) Thermic effect of food, (C) Increased sympathetic discharge, (D) Mitochondrial thermogenesis
Answer is A. Malignant hypehermia (MH) or malignant hyperpyrexia is a rare life-threatening condition that is usually triggered by exposure to ceain drugs used for general anesthesia -- specifically the volatile anesthetic agents and succinylcholine, a neuromuscular blocking agent. In susceptible individuals, these drugs can induce a drastic and uncontrolled increase in oxidative metabolism in skeletal muscleRef: Ganong&;s review of medical physiology; 24th edition; page no: 320