Epidemiologic study of Hepatitis B is by -: (A) Hbe Ag, (B) HBc Ag, (C) HBs Ag is used, (D) Anti HBc
Answer is D. Anti HBc appears in serum a week or two after the appearance of HBs Ag. It is earliest antibody marker seem in blood.&remainlifelongg,it is an indicator of prior infection with HBV REF:MICROBIOLOGY ANANTHA NARAYANAN NINTH EDITION PAGE546