Incretin like function is seen in -: (A) Exenatide, (B) Miglital, (C) Poiglitazone, (D) Repaglinide
Answer is A. Ans. is 'a' i.e., Exenatide o Exenatide is a synthetic glucagon-like peptide - 1 (GLP-l) analogue,o GLP-l is an important incretin that is released from gut in response to oral glucose.o But GLP-I can not be used clinically as it is degraded rapidly by enzyme dipeptidly peptidase - 4 (DPP-4).o Exenatide is resistant to DPP-4.o It acts similar to GLP-l -Enhancement of postprandial insulin release, suppression of glucagon release and appetite as well as slowing of gastric emptying,o It is given by subcutaneous route & used in type 2 DMo Nausea is most important side effect.