Microvesicular fatty liver is caused by ?: (A) DM, (B) Valproate, (C) Starvation, (D) IBD
Answer is B. Ans. is 'b' i.e., Valproate Steatosis Accumulation of triglyceride fat droplets within the heaptocytes is known as steatosis or fatty liver. It may be of two types ? Microvesicular steatosis - Multiple tiny droplets accumulate that do not displace the nucleus. Macrovasicular steatosis -A single large droplet accumulates that displaces the nucleus. Causes of steatosis Microvesicular Reye's syndrome Acute fatty liver of pregnancy Jamaican vomiting sickness Drugs - valproic acid, tetracycline, nucleoside analogue lman's disease Lysosomal acid lipase deficiency Congenital defects of urea cycle enzymes Early stage of alcoholic cirrhosis Chronic viral hepatitis Macrovesicular Alcoholic liver disease DM --> insulin resistance Lipodystrophy PEM, starvation Dysbetalipoproteinemia TPN, Jejunoileal bypass Inflammatory bowel disease Syndrome x (obesity, DM, hyperiglyceridemia Drugs --> CCBs, synthetic estrogens,nucleoside analogues