Cycin-D & IGH fusion gene is associated with?: (A) Mantle cell carcinoma, (B) Follicular carcinoma, (C) Melanomas, (D) Burkitt lymphoma
Answer is D. Burkitt lymphoma is a cancer of the lymphatic system, paicularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, a surgeon who first described the disease in 1958 while working in equatorial AfricaAll types of Burkitt lymphoma are characterized by dysregulation of the c-myc gene by one of three chromosomal translocations.] This gene is found at 8q24. The most common variant is t(8;14)(q24;q32), which accounts for about 85%[b of cases. This involves c-myc and IGH. A variant of this, a three-way translocation, t(8;14;18), has also been identified. A rare variant is at t(2;8)(p12;q24). This involves IGK and c-myc. Another rare variant is t(8;22)(q24;q11). This involves IGL and c-myc. Combined, the two less-common translocations, t(2;8)(p12;q24) and t(8;22)(q24;q11), account for the remaining 15% of cases not due to the t(8;14)(q24;q32) translocation