In treatment of Parkinsonism, L-Dopa is combined with carbidopa mainly:: (A) To decrease the treatment duration, (B) To decrease central side effects of L-Dopa, (C) To decrease effectiveness of L-Dopa, (D) To increase crossing of L-Dopa through BBB
Answer is D. Administered along with levodopa, they increase its W2 ir. :periphery and make more of it available to cross blood-brain barrier to reach its site of action REF: KD TRIPATHI ESSENTIALS OF MEDICAL PHARMACOLOGY