Treatment of resistant depression is ?: (A) ECT, (B) SSRI, (C) TCAs, (D) Venalafexine
Answer is A. Ans. is 'a' i.e., ECT Treatment of depression Drugs : - The treatment of major depression usually requires staing pharmacotherapy with antidepressants. Antidepressants are : - Tricyclic antidepressants (TCAs) : - Imipramine, Amitriptyline, Trimipramine, Clomipramine, Desipramine, Noriptyline, Amoxapine, Reboxetine. SSRI (selective serotonin reuptake inhibitors) : - Fluoxetine, Paroxetine, sealine, Citalopram, Escitalopram. These drugs devoid of side effects seen with TCAs and are safe in elderly. Atypical antidepressants : - Trazodone, Mianserine, Mitrazapine, Venlafaxine, Duloxetine, Tianeptine, Amineptine, Bupropion.Not all patient recover completely after treatment; about 25% cases are refractory to treatment. Recurrence rate is 50% after 1st episode and 90% after 3rd episode. ECT (Electroconvulsive therapy) : - Indications of ECT in depression are : - Suicidal risk (AI1MS 01, 00, Al 94, MAHE 01) Depression with psychotic feature Resistant depression Severe agitated or stuporous depression with lack of self care. Psychotherapy : - Suppoive psychotherapy, connitive behavioral psychotherapy.