Dohle like inclusions in neutrophils along with giant platelets is characteristic of:: (A) Bernard Soulier syndrome, (B) Chediak Higashi syndrome, (C) May Hegglin anomaly, (D) Pelger Huet anomaly
Answer is C. May-Hegglin anomaly (MHA) Autosomal dominant disorder Thrombocytopenia associated with purpura and bleeding Giant platelets containing few granules Large, well-defined, basophilic, cytoplasmic inclusion bodies in granulocytes that resemble Dohle bodies. Dohle bodies are single or multiple blue cytoplasmic inclusions that are remnants of rough endoplasmic reticulum.