The first H2 receptor blocker was synthesized in 1972 by –: (A) Asch and Child, (B) Sir James Black, (C) Gaddum and Picarelli, (D) Vane
Answer is B. Sir James Black. He synthesized the first H2 blocker burimamide; and subsequently cimetidine.
Asch and Child classified histamine receptors into H1 and H2.
Gaddum and Picarelli classified serotonin receptors into D type and M type.
Vane observed that aspirin acts by inhibiting PG synthesis.