True about chickenpox rash:: (A) Polymorphic, (B) Pleomorphic, (C) Centripetal, (D) Cytoplasmic inclusions
Answer is B. Ans. B. Pleomorphic* IP of chickenpox-10-21 days* Infectious period is 2 days before to 5 days after the onset of rash* Chickenpox is caused by VZV and reactivation of latent VZV causes shingles (also called herpes zoster).* Like HSV, VZV infects mucous membranes, skin, and neurons and causes a self-limited primary infection in immunocompetent individuals.* Rash of Chickenpox* The chickenpox rash occurs approximately 2 weeks after respiratory infection.* Lesions appear in multiple waves centrifugally from the torso to the head and extremities.* Each lesion progresses rapidly from a macule to a vesicle, which resembles a dewdrop on a rose petal.* On histologic examination, chicken pox lesions show intraepithelial vesicles with intranuclear inclusions in epithelial cells at the base of the vesicles.* After a few days most chicken pox vesicles rupture, crust over, and heal by regeneration, leaving no scars.* This phenomenon of rash is known as pleomorphic rash, where all stages of the rash (papule, vesicle and crust) may be seen simultaneously at one time in same area