Insulin increases the activities of all of the following enzymes, EXCEPT:: (A) Glucokinase, (B) Pyruvate carboxylase, (C) Glycogen synthase, (D) Acetyl-CoA carboxylase
Answer is B. B i.e. Pyruvate carboxylase Insulin increases lipogenesis (i.e. FA, TG & glycerol P synthesis) and decrease lipolysis and so free fatty acid levelQ - Insulin activate acetyl CoA carboxylase (rate limiting enzyme of FA synthesis), activate lipoprotein lipase (so increasing TG synthesis) but inhibits hormone sensitive lipase.Q - Insulin decreases gluconeogenesis by inactivating pyruvate carboxylaseQ etc and increases glycolysis by inducing phosphofructokinase and pyruvate kinase enzymesQ.