Which one has least mineralocoicoid activity?: (A) Coisol, (B) Prednisolone, (C) Fludrocoisone, (D) Methyl prednisolone
Answer is D. Coisol (Hydrocoisone) has primary glucocoicoid action and has significant mineralocoicoid activity. Prednisolone has glucocoicoid activity but at high doses fluid retention does occur. Fludrocoisone is a potent mineralocoicoid having very less glucocoicoid activity. Methylprednisolone is more selective glucocoicoid with very less mineralocoicoid activity (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition - Page No - 281)