The most impoant channel of elimination of digoxin is: (A) Hepatic metabolism, (B) Glomerular filtration, (C) Tubular secretion, (D) Excretion in bile
Answer is B. PHARMACOKINETICS Presence of food in stomach delays absorption of digoxin. The volume of distribution of digoxin is large. It is concentrated in the hea, skeletal muscle, liver and kidney. Digoxin is primarily excreted unchanged by the kidney: mainly by glomerular filtration; rate of excretion is altered parallel to creatinine clearance. Its t 1/2 is prolonged in elderly patients and in those with renal insufficiency: dose has to be reduced. Ref:- kd tripathi; pg num:-515,516