Chromosomal translocation seen in CML is?: (A) 2:08, (B) 8:14, (C) 9:22, (D) 15:17
Answer is C. In more than 90% of CML cases , BCR-ABL is created by a reciprocal (9;22) (q34;q11) translocation , the so called Philadelphia chromosome is seen. Ref: Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 617