Which diuretic can be used in treatment of hypercalcemia?: (A) Furosemide, (B) Spironolactone, (C) Hydrochlorothiazide, (D) Mannitol
Answer is A. Loop diuretics: Thiazide diuretics: Act on Na+K+2Cl- sympoer acts on ascending limb of loop of Henle. Includes- furosemide, torsemide, bumetanide High ceiling diuretics Loop looses calcium - therefore used in hypercalcemia Inhibits Na-Cl- sympoer acts on distal tubule Includes- chlohiazide,indapamide Decreases Na+, K+ , Mg2+, H+ Increases glucose, uric acid, lipid Increase in calcium - used in osteoporosis