The rate limiting enzyme in glycolysis is: (A) Glucose 6- dehydrogenase, (B) Phosphofructokinase, (C) Glucokinase, (D) Pyruvate kinase
Answer is B. (Phosphofroctokinase) (152- Harper 27th) (108- Lippincott's)Phosphofroctokinase - is the pace- setting (rate- limiting) enzyme of glycolysis. It is inhibited by ATP and citrate uses fructose 6- phosphate as substrate, and catalyzes a reaction that is for from equilibrium. The reaction is activated by fructose 2- 6 biphosphate