Which of the following syndrome is most commonly associated with clefts of lip and palate: (A) Apert syndrome, (B) Crouzon syndrome, (C) Pierre-Robin syndrome, (D) Down’s syndrome
Answer is C. Although most clefts of the lip and palate occur as an isolated deformity, Pierre Robin sequence remains the most common syndrome.
This syndrome comprises of isolated cleft palate, retrognathia and a posteriorly displaced tongue (glossoptosis), which is associated with early respiratory and feeding difficulties.