True about tachyphylaxis is:: (A) Direct sympathomimetics involved, (B) Mechanism clearly understood, (C) Ephedrine tachyphylaxis reversed with dopamine, (D) Indirect sympathomimetics involved
Answer is D. Tachyphylaxis refers to rapid development of tolerance when doses of a drug repeated in quick succession result in marked reduction in response . This is usually seen with indirectly acting drugs , such as ephedrine , Tyramine , nicotine. From medical pharmacology padmaja 4th edition page no 70