Gluconeogenesis from lactate needs all except: (A) Transpo of lactate from muscle to liver, (B) Conversion of lactate to pyruvate, (C) Transamination of pyruvate to alanine, (D) None of the above
Answer is C. The lactate formed in the muscle is transpoed to the liver. In the liver cell lactate dehydrogenase conves lactate to pyruvate (Fig. 9.28). The pyruvate enters the gluconeogenic pathway to form glucose.Ref: DM Vasudevan, 7th edition, page no: 119