Receptor agonists possess:: (A) Affinity but no intrinsic activity, (B) Intrinsic activity but no affinity, (C) Affinity and intrinsic activity with a + sign, (D) Affinity and intrinsic activity with a - sign
Answer is C. Ans. C. Affinity and intrinsic activity with a + signa. Agonist: Drug having affinity and intrinsic activity (IA)/efficacyb. Antagonist: Drug having affinity but no intrinsic activityc. Inverse agonist: Having affinity and intrinsic activity which is opposite to that of agonist e.g. beta carbolines at BDZ receptord. Partial agonist: Drug having affinity and intrinsic activity (IA)/efficacy less than agonist