Which of the following disorders is NOT aggravated by coicosteroid therapy?: (A) Congenital adrenal hyperplasia, (B) Diabetes mellitus, (C) Hypeension, (D) Peptic ulcer
Answer is A. (Ref: KDT 6/e p283) Coicosteroids are used for the management of congenital adrenal hyperplasia. Coicosteroids can result in hyperglycemia and thus may vitigate the control of blood glucose in diabetics. Due to retention of Na+ and water, coicosteroids can worsen the hypeension. By inhibiting the production of gastroprotective prostaglandins, coicosteroids increase the risk of peptic ulcer disease.