True regarding multiple myeloma is all. except :: (A) Bone pain, (B) Lytic lesion, (C) Increased alkaline phosphatase, (D) Taerate resistance acid phosphatase positive
Answer is C. Answer is C (Increased alkaline phosphatase) Serum Alkaline phosphatase is usually normal even with extensive bone involvement because of absence of osteoblastic activity - Harrisons 16th/ 659 Bone pain is the most common symptom in myeloma Q Bone lesions are lytic in nature and are rarely associated with osteoblastic new bone formation. Therefore Radioisotope bone scanning is less useful in diagnosis than plain radiography c) No hot spot is seen on bone scan Q Alkaline phosphatase (marker of osteoblastic activity) is not raised.