A 50 year old male presented with symptoms of cutaneous vasculitis, glomerulonephritis and synovitis. Which of the following investigations will be helpful in the diagnosis?: (A) P-ANCA, (B) C-ANCA, (C) Anti-HCV antibody, (D) Anti-HAV antibody
Answer is C. Essential mixed cryoglobulinemia: Formation of immune complexes (IgM -IgG) Development of renal lesions and involvement of joints (MPGN I and synovitis) Most cases have been associated with hepatitis C virus infection. Deposits of IgG-IgM complexes induce Cutaneous vasculitis Synovitis MPGN