Detection rate of down syndrome with first trimester screening with NT, PAPP-A and hCG is: (A) 64-70%, (B) 80-84%, (C) 94-96%, (D) 99%
Answer is B. Selected Down Syndrome Screening Strategies and Their Detection RateScreening testDetection rateQuadruple screen 80-82%First trimester screenNT alone64-70%NT, hCG, PAPP-A80-84%Integrated screening94-96%Sequential screeningStepwise92%Contingent91%Cell-free DNA91%(Ref: William's Obstetrics; 25th edition)