Inhibition of 5-lipooxygenase is useful in:: (A) Cardiac failure, (B) Bronchial asthma, (C) Hepatic failure, (D) Arthritis
Answer is B. Ans. (B) Bronchial asthma(Ref: KDT 8th/e p248, 249)Leukotrienes are potent bronchoconstricting agents. These agents play a major role in the pathogenesis of bronchial asthma. The drugs acting by inhibiting their synthesis (i.e. lipoxygenase inhibitors) or action (Cys-LT receptor antagonists), are useful in the prophylaxis of bronchial asthma.