Pancuronium differs from tubocurarine in that:: (A) It is a depolarizing blocker, (B) Its action is not reversed by neostigmine, (C) It can cause rise in BP on rapid I.V. injection, (D) It causes marked histamine release
Answer is C. * Pancuronium possesses vagolytic activity and can cause hypeension and tachycardia on rapid i.v. injection. * Pancuronium is a competitive NM blocker (Non-depolarizing NM blocker). Its actions can be reversed by anticholinesterases like neostigmine. * Unlike d-TC, histamine release is not seen with pancuronium.