A patient was taking warfarin and INR comes out to be 8. Next step would be to stop the drug and:-: (A) Resta at a lower dose once the INR is in therapeutic range, (B) Give oral vitamin K1, (C) Administer fresh frozen plasma, (D) Transfuse fresh blood
Answer is B. Management of warfarin overdose is done as follows: *INR < 5 but above therapeutic range - Discontinue warfarin temporarily and resta at low dose. *INR 5-9 - Vitamin K1 (1 mg oral) *INR > 9 but no bleeding - Vitamin K1 (2 - 3 mg oral) *INR > 20 or bleeding - Four factor prothrombin complex or Fresh frozen plasma.