Which of the following aminoglycoside is cochleotoxic:: (A) Kanamycin, (B) Streptomycin, (C) Gentamycin, (D) Minocycline
Answer is A. Ref: Goodman & Gillman 13th ed. P 1044-45* All aminoglycosides have the potential to produce reversible and irreversible vestibular, cochlear, renal toxicity and neuromuscular blockade.* Aminoglycoside-induced ototoxicity may result in irreversible, bilateral, high-frequency hearing loss or vestibular hypofunction.* A high-pitched tinnitus often is the first symptom of cochlear toxicity.* Drugs like amikacin, neomycin and kanamycin are specifically cochleotoxic > vestibulotoxic.* Gentamicin, streptomycin is vestiblar > cochleotoxic* Tobramycin: Cochlear = Vestibular toxicity both.