The half-life of Digoxin is: (A) 24hours, (B) 40hours, (C) 48hours, (D) 60hours
Answer is B. Digoxin is not extensively metabolized in humans; almost two-thirds is excreted unchanged by the kidneys. Its renal clearance is propoional to creatinine clearance, and the half-life is 36-40 hours in patients with normal renal functionReference: Katzung Pharmacology; 13th edition; Chapter 13; Drugs Used in Hea Failure