About Ramelteon, which of the following is not true?: (A) MT1 and MT2 receptor antagonist, (B) Metabolized by Cytochrome p450, (C) No significant addictive potential, (D) Useful in long-term treatment of insomnia
Answer is A. Ramelteon is melatonin receptor agonist, rapidly absorbed and undergoes extensive first-pass metabolism. Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 and MT2 receptors and selec vity over the MT3 receptor.