Which of the functions are TRUE regarding C-terminal domain of androgen receptor protein?: (A) Ligand binding, (B) Increasing biological half life, (C) Increasing the affinity of receptor to DNA, (D) Increasing the level of transcription
Answer is A. The androgen receptor proteins contain 3 common domains: 1- Highly conserved central domain that is responsible for DNA binding 2- N-terminal region that is involved in trascriptional activation, and 3- C-terminal domain that binds ligand Ref: Harper's Illustrated Biochemistry 27th Edition, Page 477; Molecular cell biology, December 19 (12); 8383 - 8392; Urotext Basics By R. A. S. Hemat, Edition 2003, Page 68.