Most impoant mechanism of development of resistance to drugs in tuberculosis is: (A) Transduction, (B) Conjugation, (C) Transformation, (D) Mutation
Answer is D. Most impoant mechanism of development of resistance to anti-tubercular drugs is mutation. DRUG RESISTANCE MUTATION IN GENE Rifampicin rpoB Isoniazid katG and inhA Ethambutol embB Pyrazinamide pncA