Causes for less bioavailability -: (A) High first pass metabolism, (B) Increased absorption, (C) IV drug administration, (D) High solubility
Answer is A. Ans. is 'a' i.e., High first pass metabolism o Causes for less bioavailability. Incomplete absorption o High first pass metabolism. About other options Increased absorption increases bioavailability. o I.V. administration has 100% bioavailahi I ity. High lipid solubility causes more absorption and better bioavailability.