Vigorous treatment of nephritis in SLE is indicated in:: (A) Class I & II, (B) Class III & IV, (C) Class IV & V, (D) Class V & VI
Answer is B. Renal Biopsy in SLE: The pattern and severity of injury are impoant in diagnosis and selecting the best therapy. Aggressive immunosuppressive treatment is indicated in : Class III and IV disease Class V accompanied by III or IV disease Treatment for lupus nephritis is not recommended in class I or II disease or with extensive irreversible changes. Classification of Lupus Nephritis (International Society of Nephrology and Renal Pathology Society) Class I: Minimal Mesangial Lupus Nephritis Class II: Mesangial Proliferative Lupus Nephritis Class III: Focal Lupus Nephritis Class IV: Diffuse Lupus Nephritis Class V: Membranous Lupus Nephritis Class VI: Advanced Sclerotic Lupus Nephritis Ref:Harrison,E-18,P-2733