Vitamin K is given to a patient with jaundice, but PT remains unchanged. Probable cause is: (A) Obstructive Jaundice, (B) Cirrhosis, (C) Hemolytic Jaundice, (D) Pre-renal Failure
Answer is B. An elevated prothrombin time indicates either vitamin K deficiency due to prolonged jaundice and malabsorption of vitamin K or significant hepatocellular dysfunction. The failure of the prothrombin time to correct with parenteral administration of vitamin K indicates severe hepatocellular injuryReference: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 58; Jaundice