True statement regarding Hirschsprung's disease –: (A) Giant ganglia are present, (B) Mucosa is involved and show foldings, (C) Manometry excludes the disease, (D) Rectal biopsy is contraindicated in infants
Answer is C. Anorectal manometry is a useful screening procedure for the diagnosis of Hirschsprung's disease. A normal response in course of manometric evaluation precludes diagnosis of Hirschsprung's disease.
However the confirmation of diagnosis in case of Hirschsprung's disease is done by rectal biopsy.