Function of infliximab used in Crohn&;s is: (A) Inhibit TNF-a, (B) Inhibit IL-2, (C) EGFR inhibitor, (D) Inhibit VEGF
Answer is A. Infliximab, a chimeric IgG1 antibody against TNF-a, is approved for treatment of moderately to severely active UC.Infliximab is also effective in CD patients with refractory perianal and enterocutaneous fistulasAdalimumab and ceolizumab, golimumab are other Anti-TNF therapies approved for IBDInfliximab is also approved for psoriasis, psoriatic ahritis, ankylosing spondylitis, and rheumatoid ahritisRef: Harrison 19e pg: 1961