In Wilms tumor the following leads to emergence of resistance to chromotherapy: (A) Nehprogenic rests, (B) Monoblastic morphology, (C) Anpalsia, (D) Capsular infiltration
Answer is C. 5 percnt of tumors have Anpalsia, defined as the presence of cells with large hyperchromatic pleomprphic nuclei and abnormal mitosis and the presrnc of anapladsia coreltes with p53 mutation