Which of the following is not true of acute PSGN (Post Streptococcal glomerulonephritis)?: (A) Electron dense humps on GBM, (B) PSGN following streptococcal skin infection will usually show ASLO titre positive, (C) Renal biopsy is indicated if prolonged hypocomplementemia persists beyond 2 months, (D) C3 is low in acute phase returns to normal in 6 - 8 weeks
Answer is B. In PSGN, ASO titer is increased in more than 80% patients following streptococcal sore throat; anti-DNase B is elevated in cases of streptococcal skin infection. The level of serum C3 is low in 90% patients but normalizes by 6 - 8 weeks. Persistent low C3 levels indicate other forms of GN and requires renal biopsy On electron microscopy, electron-dense deposits, or "humps," are observed on the epithelial side of the glomerular basement membrane