All of the following are true regarding progressive multifocal leukoencephalopathy except: (A) Only manifestation of JC virus infection, (B) Late manifestation of AIDS, (C) Cerebellar involvements is unknown, (D) none
Answer is C. . *Progressive multi focal leukoencephalopathy characterised by cytological alternations in both astrocytes and oligodendrocytes . *Oligodendrocytes are enlarged ,densely staining nuclei that contain viral inclusions formed by crystallinearrays of JC virus paicles *Almost all patients will have underlying immunocompromissive disorders ,most common associated condition is AIDS(80%), hematological malignancy(13%), transplant recipient(5%) and chronic inflammatory disease(2%). Ref Harrison20th edition pg 2456