True about benzodiazepines -: (A) Increased release of GABA, (B) Antagonzing release of GABA, (C) Lorazepam is shoer acting than temazepam, (D) Atropine is its antagonist
Answer is C. Ans. is 'c' i.e., Lorazepam is shoer acting than temazepam o Lorazepam has t1/2 10-20 hours, while Temazepam has t1/2 10-40 hours. About other options o BZDs do not increase or decrease the release of GABA, they bind on GABAA receptors and increase Cl- conductance --> GABA facilitatory action. o Flumazenil (not atropine) is the antagonist of BZDs.