Gene for Wilms tumor is located on-: (A) Chromosome 11, (B) Chromosome 1, (C) Chromosome10, (D) Chromosome12
Answer is A. Mutations of the WT1 gene on chromosome 11p13 are observed in approximately 20% of Wilms tumors.
At least half of the Wilms tumors with mutations in WT1 also carry mutations in CTNNB1, the gene encoding the proto-oncogene beta-catenin.