Decreased osmotic fragility is not seen in which of the following conditions?: (A) Thalassemia, (B) Hereditary spherocytosis, (C) Sickle cell anemia, (D) Iron deficiency
Answer is B. - Hereditary spherocytosis is associated with increased osmotic fragility because RBCs are spherical & unstable d/t defect in their cytoskeleton. Osmotic fragility curves of normal and hereditary spherocytosis red blood cells.