AML with worst prognosis:: (A) 8/21 translocation, (B) Inversion 16, (C) Normal cytogenetics, (D) Monosomy 7
Answer is D. PROGNOSIS OF AML: Good prognostic factors: t(8;21) inv16 t(15;17) CEBPA mutation NPM mutation Down syndrome Bad prognostic factors: Monosomy 7 5q deletion FLT3 - internal tandom duplication