Perifascicular atropy of muscle fibres is seen in?: (A) Steroid myopathy, (B) Dermatomyositis, (C) Inclusion body myositis, (D) Nemaline myopathy
Answer is B. Ans. is 'b' i.e., Dermatomyositis Dermatomyositis is a connective-tissue disease related to polymyositis that is characterized by inflammation of the muscles and the skin. It is a systemic disorder that may also affect the joints, the esophagus, the lungs, and, less commonly, the hea. On the muscle biopsy, there are two classic microscopic findings of dermatomyositis. They are : mixed B- & T-cell perivascular inflammatory infiltrate and perifascicular muscle fiber atrophy. It is associated with autoantibodies, especially anti-Jol antibody.