Which of the following drug can result in cerebellar toxicity?: (A) Cyclophosphamide, (B) Cisplatin, (C) Cytarabine, (D) Actinomycin D
Answer is C. Cytarabine is pyrimidine analogue At higher dose it is known to cause cerebellar toxicity like ataxia, dysahria. other side effects- myelosuppression,mucositis,nausea and vomiting. Cyclophosphamide causes hemorrhagic cystitis Cisplatin is most emetogenic anticancer drug. Actinomycin D and doxorubicin can cause vomiting,stomatitis,diarrhoea,erythema,desquamation of skin,alopecia and bone marrow suppression.