False statement about diffuse carcinoma of the stomach is:: (A) It is seen mostly in older individuals, (B) Leather Bottle appearance, (C) Loss of expression of E-cadherin, (D) Poorer prognosis
Answer is A. Gastric adenocarcinomas divided into two categories: Diffuse type It Infiltrate and thicken the stomach wall without forming a discrete mass In younger patients Linitis plastica, or "leather bottle" appearance Loss of expression of E-cadherin Carry a poorer prognosis Intestinal type Frequently ulcerative Commonly appear in the antrum and lesser curvature Precancerous process, often initiated by Helicobacter pylori infection Ref: Harrison,E-18,P-765