Mutation in Marfan's syndrome is?: (A) Collagen I, (B) Collagen IV, (C) Fibrillin I, (D) Fibrillin II
Answer is C. Robbins and Cotran pathologic basis of disease South Asia edition. * Marfan's syndrome results from an inherited defect in an extracellular glycoprotein called fibrillin 1 by loss of structural suppo in microfibril rich connective tissues and excessive activation of TGF- beta signally Ref Robbins 9/e pg252