Patient with hemophilia A have bleeding disorder because of:: (A) Lack of platelet aggregation, (B) Lack of reaction accelerator during activation of factor X in coagulation cascade, (C) Neutralization of antithrombin III, (D) Release of Thromboxane A2
Answer is B. Hemophilia A - X- linked disorder -90% cases- deficiency of factor 8 -10% cases - functional defect of factor 8 -Intrinsic Pathway affected -Factor VIIIa complex is the most impoant activator of factor X required for conversion of prothrombin to thrombin. -In symptomatic cases there is a tendency toward easy bruising and massive hemorrhage after trauma or operative procedures