A male infant presented with distension of abdomen shortly after birth with passing of less meconium. Subsequently a full-thickness biopsy of the rectum was performed. The rectal biopsy is likely to show:: (A) Fibrosis of submucosa, (B) Lack of ganglion cells, (C) Thickened muscularis propria, (D) Hyalinization of the muscular coat
Answer is B. b. Lack of ganglion cells(Ref: Nelson's 20/e p 1894-1897, Ghai 8/e p 285-286)"Whenever neonate presents with delayed passage of stool, Hirschsprung's disease should be suspected".