Which antihypeensive is a prodrug and is coveed to its active form in brain?: (A) Clonidine, (B) Methyldopa, (C) Minoxidil, (D) Nitroprusside
Answer is B. (Ref: KDT 6/e p547) Although both methyldopa and minoxidil are produrgs, conversion of methyldopa to a-methylnorepinephrine takes place in the brain whereas minoxidil is activated to minoxidil sulphate (by phase II reaction) in the periphery.