Benzodiazepine binding ste on GABA receptors is on ?: (A) y-subunit, (B) a-subunit, (C) b-subunit, (D) d-subunit
Answer is B. Ans. is'b'i.e., a-subunitThe exact subunit structures of native GABA receptors are still are unknown, but it is thought that most GABA receptor are composed of alpha, beta & gamma subunits that Coassemble with some unceain stoichiometry.Binding site of GABA is on beta-subunit.Benzodiazepine site is located on the a subunit but the stabilization or completion of that site in the assembled. Structure also requires the y subunit.