Lubiprostone is a:: (A) Chloride channel activator, (B) Chloride channel inhibitor, (C) Sodium channel activator, (D) Sodium channel inhibitor
Answer is A. Lubiprostone :- selectively stimulates type 2 chloride channels in epithelial cells thereby causing an efflux of chloride into the intestinal lumen. - The resultant fluid secretion into the gastrointestinal lumen provides a bolus effect that softens stool, increases intestinal transit, and improves symptoms of constipation. - Lubiprostone acts locally within the intestinal tract, is rapidly metabolized, and has very low systemic bioavailability.