Which of the following enzyme of Heme synthesis is located in mitochondria?: (A) ALA synthase, (B) ALA dehydratase, (C) Uroporphyrinogen I synthase, (D) Uroporphyrinogen decarboxylase
Answer is A. First reaction and the last 3 reactions of heme synthesis take place in the mitochondria. The rest of them takes place in cytosol. Figure: Heme synthesis occuring in mitochondrion & cytosol