True about Alpha1 antitrypsin deficiency is?: (A) Deficiency of protease inhibitor, (B) Autosomal recessive, (C) May cause cholestatic jaundice, (D) All of the above
Answer is D. (255) All of the above REF: Robbin's 7th ed p. 913 Alpha 1 antitrypsin deficiency: Due to protease inhibitor deficiency Increased neutrophill elastase Neonatal cholestasis may occur, Hepatocellular carcinoma may also develop Pulmonary disease may occur in form of emphysema Gene located on chromosome 14