In inflammatory carcinoma breast with metastasis to axilla, treatment of choice:: (A) NACT + MRM + Radiotherapy, (B) Radical mastectomy plus chemotherapy, (C) Radical mastectomy plus radiotherapy, (D) Chemotherapy followed by hormone therapy
Answer is A. Hallmark of inflammatory breast Ca is diffuse tumour involvement of dermal lymphatic channel breast & overlying skin, often without an underlying tumour mass. Presents with inflammatory changes like erythema, edema (peau de orange) warmth as a result of lymphatic obstruction. At least 33% skin over breast involved. History of rapid onset & progression. Inflammatory breast Ca is a clinical diagnosis & can occur with tumour of ductal or lobular histology Inflammatory breast Ca = stage T4d, corresponds to stage IIIB i.e. locally advanced breast Ca. Rx: NACT + MRM + .