Mucosal melanosis and hamaomatous polyps are seen in?: (A) Peutz-Jeghers syndrome, (B) Cronkhite Canada syndrome, (C) Familial adenomatous polyposis, (D) Hereditary non polyposis colonic cancer
Answer is A. Peutz-jeghers syndrome: Autosomal dominant disorder Mutation- STK 11 / LKB1 gene Multiple gastrointestinal hamaomatous polyps + Mucocutaneous hyperpigmentation Increased risk for colon, pancreas, breast, lung, ovaries, uterus, testes neoplasms Gross- Polyps are large & pedunculated with lobulated contour.