The phenomenon where subsequent generations are at risk of earlier and more severe disease is known as: (A) Anticipation, (B) Pleiotropy, (C) Imprinting, (D) Mosaicism
Answer is A. Ref Robbins 9/e p169 Anticipating refers to observation that clinical features of a genetic disease worsen with each successive generations.it is observed in fragile X syndrome and Huntington disease commonly