All are true about sulphonyl ureas except?: (A) It blocks ATP sensitive K+ channels and increase insulin release, (B) They have higher risk of causing hypoglycemia than meglitinides, (C) They are used mainly in type 1 DM, (D) Chlorpropamide can cause dilutional  hyponatremia
Answer is C. Sulphonyl ureas are mainly used in Type 2 DM because Type 1 DM is characterized by autoimmune destruction of β - cells of pancreas and atleast 30% of β - cells should be present for sulphonyl ureas to be effective.