In measles, when do the Koplik's spots appear?: (A) On the day that fever occurs, (B) On the day that rashes appear, (C) 1 -3 days before the rashes appear, (D) 1-2 days before the fever occurs
Answer is C. In measles ,a prodromal illness,1-3 days before the rash,occurs ,with upper respiratory symptoms ,conjunctivitis , & the presence of the pathognomonic Koplik's spots,small white spots surrounded by erythema on the buccal mucosa. Reference: Harrison20th edition pg 879