An ICU patient on atracurium infusion develops seizures after 2 days. The most probable cause is –: (A) Accumulation of landonosine, (B) Allergy to drug, (C) Due to prolong infusion, (D) All of the above
Answer is A. Hofmann degradation of atracurium produces tertiary metabolite laudanosine which can cross blood brain barrier and produces convulsions.