Pyruvate utilisation is decreased in:: (A) Pernicious anemia, (B) Scurvy, (C) Folate trap, (D) Beri-beri
Answer is D. PDH complex requires five coenzymes - Vitamin B1, B2, B3, B5 and Lipoic acid. Vitamin B1 deficiency - Beri-beri Beri- beri - |PDH activity - | pyruvate to acetyl-CoA conversion - low pyruvate utilization Vitamins (B1, B2, B3, B5) - decreased energy production and CNS problems (brain cells depend upon this aerobic reaction)