E- cadherin mutation is seen in which type of carcinoma:: (A) IDC, (B) Lobular carcinoma, (C) Metabplastic carcinoma, (D) Metastasis
Answer is B. Loss of E cadherin can contribute to malignant phenotype by allowing easy disintegration of cell which can then invade locally and metastasize. Reduced cell surface expression of E cadherin has been noted in many carcinomas : Stomach carcinoma Breast carcinoma Prostate carcinoma Ovarian carcinoma