A neonate following BCG vaccination developed a side effect. Which of the following side effect would the neonate most likely develop after vaccination?: (A) Fever, (B) Ulceration, (C) Osteomyelitis, (D) Regional lymphadenitis
Answer is B. Ulceration is the most common side effect post BCG vaccination. Following vaccination, the local tissue response begins in 2-3 weeks, with scar formation and healing within 3 months. Side effects most commonly are ulceration at the vaccination site and regional lymphadenitis. Some vaccine strains also rarely cause osteomyelitis. In immunocompromised states, disseminated BCG infection can occur. Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition