The major source of NADPH for fatty acidsynthesis ?: (A) PPP, (B) TCA cycle, (C) Glycolysis, (D) Glycogenolysis
Answer is A. Ans. is 'a' i.e., PPP Source of NADPH for lipogenesis NADPH is involved as donor of reducing equivalentse in both the reduction of 3-ketoacyl by 3 ketoacyl reductase and of 2,3- unsasturated acyl by enoyl reductase. The main source of NADPH for lipogenesis is the pentose phosphate pathway: PPP (Hexose monophosphate shunt: HMP shunt)deg. Other sources of NADPH include:- The reaction that conves malate to pyruvate catalyzed by malic enzyme. Exramitrochondrial isocitrate dehydrogenase.