Exenatide is a new drug used in diabetes mellitus. Mechanism of action of this drug is:-: (A) Inhibition of DPP- 4, (B) Release of insulin acting as agonist of GLP-1 receptors, (C) Inhibiting intestinal absorption of carbohydrates, (D) Stimulation of PPAR-gamma
Answer is B. (a) Exogenous GLP-1 agonist --> Exenatide, Liraglutide --> given SC Analogues. (b) DPP-4 Inhibitors --> Sitagliptin, Vildagliptin --> given orally. (c) Inhibition of Intestinal absorption of carbohydrate --> Acarbose. (d) Stimulation of PPAR - gamma --> Piaglitazone, Rosiglitazone