Most specific histological lesion in diabetic nephropathy is-: (A) Glomerular crescents, (B) Immune complex deposition, (C) Occlusion of glomeruli with fibrin caps, (D) Nodular glomerulosclerosis
Answer is D. Nodular lesions of diabetic glomerulosclerosis are also called as Kimmelstiel- Wilson (KW) lesions or intercapillary glomerulosclerosis. These lesions are specific for type 1 diabetes (juvenile onset diabetes) or islet cell antibody-positive diabetes mellitus. The pathologic changes consist of one or more nodules in a few or many glomeruli. the nodule is an ovoid or spherical, laminated, hyaline, acellular mass located within a lobule of the glomerulus. Ref: Harsh Mohan textbook of pathology 6th edition page678