Which of the following antibody is incriminated in causing henoch schonlein purpura: (A) IgA, (B) IgM, (C) IgG, (D) IgD
Answer is A. Henoch schonlein purpura(IgA vasculitis) is characterized by Paplable purpura(most commo buttocks and lower extremities) Ahralgia Gastrointestinal signs and symptoms Glomerulonephritis Pathogenesis:immune complex deposition .IgA antibody class is the most often seen in immune complexes. Ref:Harrison 20th edition pg no 2586