Main abnormality in beta-thalassemia minor is: March 2011: (A) Increased HbA2, (B) Severely increased, (C) HbFSevere anemia, (D) All of the above
Answer is A. Ans. A: Increased HbA2 Haemoglobin electrophoresis in beta-thalassemia minor usually reveals an increase in HbA2 (alpha2, gamma2) to 4-8% of the total hemoglobin (normal 2.5%)