Metabolic alkalosis seen in following except -: (A) Methanol poisoning, (B) Cushing's disease, (C) Vomiting, (D) Diuretic therapy
Answer is A. Methanol is initially metabolized by alcohol dehydrogenase to formaldehyde, with subsequent oxidation to formic acid, then to CO2 & water. Formic acid is responsible for metabolic acidosis with increased anion gap & renal toxicity.