Apparent volume of distribution (Vd) of a drug exceeds total body fluid volume, if a drug is:: (A) Sequestrated in body tissues, (B) Slowly eliminated from body, (C) Poorly soluble in plasma, (D) Highly bound to plasma proteins
Answer is A. Ans. (A) Sequestered in body tissues(Ref: KDT 8th/e p24)* Apparent volume of distribution (Vd ) is more for drugs sequestered in tissues.* Lipid insoluble drugs do not enter cells, Vd approximates ECF volume.