bcl2 in B-cell lymphoma the translocation involving-: (A) t (8 : 14), (B) t (8 :12), (C) t(14:18), (D) t(14 : 22)
Answer is C. In all follicular lymphomas ,the tumour cells are positive for pan-B markers such as CD19& CD20 along with expression of BCL2 protein .Cytogenic studies show characteristic translocation t(14;18) in tumor cells. Ref: Harshmohan textbook of pathology pg 356