CD59 deficiency leads to:: (A) PNH, (B) Chediak-Higashi disease, (C) Hairy cell leukemia, (D) Hemolytic uremic syndrome
Answer is A. Ref. Robbins Pathology. 9th edition. Page. 642
PNH :

Defect in GPI linked proteins  - CD55 and CD 59
Mutation in PIGA gene
Intravascular hemolysis
Triad – IV hemolysis, Thrombosis, Pancytopenia
Can result in AML
Diagnostic methods


HAM test – no more used
Gel card test
Flow cytometry – IOC
Best – FLAER (Fluorescent Aerolysin test)