Most common cause of death in Menke disease: (A) Cardiac rupture, (B) Diaphragmatic paralysis, (C) Laryngeal spasm, (D) Cyano-methemoglobinemia
Answer is B. Menkes disease, also known as kinky hair disease, is an X-linked neurodegenerative disease of impaired copper transpo The major problems in Menkes disease involve the neurologic, gastrointestinal, and connective tissue (including blood vessels) systems. Pneumonia, leading to respiratory failure, is a common cause of death and also diaphragmatic paralysis Ref Robbins 9/e pg 170