Resistance to Zidovudine develops due to: (A) Mutation at reverse transcriptase, (B) Increased efflux of the drug from inside the cell, (C) Increased metabolism of drug, (D) Decreased Zidovudine 5 triphosphate formation
Answer is A. Zidovudine is a nucleoside reverse transcriptase inhibitors which is a viral enzyme .HIV undergoes mutations in this enzyme to become resistant to NIs Refer :KDT 6/e p770