Mechanism of action in pathogenesis of Pseudomembranous colitis by CI difficle ?: (A) Due to invasiveness, (B) Due to endotoxin, (C) Due to exotoxin, (D) Due to NM blockade
Answer is C. Ans. is 'c' i.e., Due to exotoxin Pathogenesis of pseudomembranous colitis is due to production of two large toxins by C. difficile : i) Toxin A (an enterotoxin) Is a potent neutrophil chemoattractant Causes disruption of cell cytoskeleton by glycosylation of GTP - binding proteins that regulate the actin cell cytoskeleton. ii) Toxin B (a cytotoxin) Causes disruption of cell cytoskeleton by similar mechanism.