Which of the following does not cross a blood brain barrier: (A) Pralidoxime, (B) Obidoxime, (C) Diacetylmonoxime, (D) Physostigmine
Answer is A. Ref-Katzung 11/e p121 Pralidoxime or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. It is used to treat organophosphate poisoning in conjunction with atropine and diazepam