Dent's disease is characterized by all except: (A) Chloride channel defect, (B) Males are affected, (C) Nephrolithiasis, (D) Defect in limb of Loop of Henle
Answer is D. Answer- D. Defect in limb of Loop of HenleDent's disease refers to heterogenous group of X-linked disorders. It b characterized by manifestations of proximal tubule dysfunction (PT) dysfunction associated with hypercalciuria nephrolithiasis, nephrocalcinosis and progressive renalfailureThese features are found in males only.mutation in gene encoding CLS-S, a Voltage gated Chloide channel.