The following are recognized features of pan-hypopituitarism except?: (A) Increased insulin sensitivity, (B) Pigmentation of the mucous membranes, (C) Low serum thyroxine and TSH levels, (D) Loss of secondary sex characters
Answer is B. Since ACTH has a paial MSH(Melanocyte Stimulating Hormone) like activity and levels of ACTH in Pan-hypopituitarism will fall, the hyperpigmentation cannot occur. However diseases with Increased ACTH like Addison disease will show hyperpigmentation. Insulin sensitivity implies hypoglycemia. LH/FSH fall will cause loss of secondary sexual features.