Which investigation should be done for diagnosis of idiopathic membranous glomerulopathy?: (A) Antibody to PLA2R on podocytes, (B) Kidney biopsy with immunofluorescent staining, (C) C3, C4 and CH50 levels, (D) c-ANCA titers
Answer is A. Membranous Glomerulopathy associate with Malignancy The anti-PLA2R antibody (Anti-phospholipase A2 Receptor antibody) attaches to the phospholipase A2 receptor (the antigen). The phospholipase A2 receptor is a protein found in the kidney filter (glomerulus), specifically within a cell called the podocyte which makes up pa of this filter Diagnosed by- protein in the urine and kidney biopsy