Which malignancy would occur in long-standing multinodular goitre?: (A) Papillary Carcinoma, (B) Follicular Carcinoma, (C) Anaplastic Carcinoma, (D) Medullary Carcinoma
Answer is B. The incidence of follicular carcinoma is high in endemic goitrous areas, with long-standing multinodular goitre, possibly owing to persistent TSH stimulation.Dominant or rapidly growing nodules, especially in longstanding goitres, should always be subjected to aspiration cytology.