Alpha-1 antitrypsin acts to prevent lung tissue destruction by: (A) Inhibiting the release of trypsin, (B) Inhibiting the activation of trypsinogen, (C) Inhibiting the release of chymotrypsin, (D) Inhibiting the elastase of neutrophils in lung
Answer is D. Answer- D. Inhibiting the elastase of neutrophils in lungThe most accepted theory in the pathogenesis of emphysema is protease - antiprotease mechanism which is responsible in the pathogenesis of two common forms of emphysema, i.e. centriacinar and panacinar.A) Pathogenesis of panacinar emphysemaPanacinar emphysema is associated wlth congenital deficiency of alpha 1-antitrypsin.Neutrophil are the major cell in the pathogenesis of panacinar emphysema.B) Pathogenesis of centriaginar emphysema in centriacinar emphysema, both neutrophils and macrophages play central role.