Which of the following is used to maintain abstinence in alcohol dependence: (A) Naltrexone, (B) Clonidine, (C) Disulfiram, (D) Naloxone
Answer is A. Naltrexone (oral opioid receptor antagonist) probably interferes with alcohol-induced reinforcement by blocking opioid receptors., helping in maintaining alcohol abstinence. Ref: Sho textbook of Psychiatry by Niraj Ahuja 7th editon, page 42. Disulfiram also helps in alcohol abstinence but through its unpleasant reactions to alcohol intake.