Anti-coagulant of choice for heparin induced thrombo.. Cytopenia is?: (A) Lepirudin, (B) Aprotinin, (C) Abciximab, (D) Plasminogen
Answer is A. Lepirudin is a parenterally acting direct thrombin inhibitor. They inactivate fibrin bound thrombin in their clots since their activity is independent of antithrombin III. It&;s use has been approved in HIT. From medical pharmacology padmaja 4th edition Page no 338