HER-2/neu gene causes breast carcinoma due to: (A) Overexpression, (B) Suppression, (C) Mutation, (D) Translocation
Answer is A. Answer- A. OverexpressionHER2/neu or ERBB2 gene which encodes for Receptor tyrosine-protein kinase erbB-2, also known as CD340.Amplification or over-expression of this oncogene has been shown to play an impoant role in the development and progression of ceain aggressive types of breast cancer.