Which of the following adverse effects is characteristically associated with methysergide?: (A) Pulmonary hypeension, (B) Retroperitoneal fibrosis, (C) Hepatotoxicity, (D) Ischemic hea disease
Answer is B. All ergot derivatives can cause fibrosis on long term use. Due to risk of retroperitoneal fibrosis, methysergide should never be given continuously for more than 6 months.