WAGR syndrome is caused by defect in which chromosome:: (A) 6, (B) 10, (C) 11, (D) 14
Answer is C. WAGR syndrome is characterized by genital anomalies, aniridia, hemihyperophy, and Wilms' tumor. The constellation of defects is due to a microdeletion in chromosome 11 that includes both the PAX6 (aniridia) and WT1 genes that are only 700 kb apa. Ref: Langman's embryology 11th edition Chapter 15.