Mutation in COL4A5 chain the diagnosis ?: (A) Alpo's syndrome, (B) Good pasture's syndrome, (C) Hereditary Non-polyposis colon cancer, (D) Keroderma pigmentosum
Answer is A. Ans. is 'a' i.e., Alpo's syndromeo Manifestations of Alpo's syndrome are due to abnormal a3 (COL4A3), a4 (COL4A4), or a5 (COL4A5). o This is due to mutations of :i) COL4A5 in classic X-linked formii) COL4A.3 or COL4A4 in autosomal forms.