All of the following nondepolarising neuromuscular blocker causes histamine release except-: (A) Atracurium, (B) Mivacurium, (C) d-tubocurare, (D) Vecuronium
Answer is D. All benzylisoquinoline nondepolarising neuromuscular blocker causes histamine release. Aminosteroid group does not release histamine. NDNB divided in three group according to duration of action - Long- acting, intermediate - acting and sho- acting. Aminosteroid Long acting Pancuronium pipecuronium Benzylisoquinoline D-tubocurane, Doxacurium Intermediate acting Aminosteroid Vecuronium Rocuronium Benzylisoquinoline Atracurium Cisatracurium Sho acting Aminosteroid Rapacuronium Benzylisoquinoline Mivavcurium * Benzylisoquinoline group causes histamine release so IV injection of these drugs can cause hypotension,tachycardia, Bronchospasm, Flushing.