Macrophages containing large quantities of undigested and partial digested bacteria in the intestine are seen in -: (A) Whipple's disease, (B) Amyloidosis, (C) Immunoproliferative small intestinal disease, (D) Vibrio cholerae infection
Answer is A. The hallmark of Whipple’s disease is a small intestinal mucosa laden with distended macrophages in the lamia propria.
The macrophages contain periodic acid– Schiff (PAS) positive granules and small rod shaped bacilli)