Changes seen in early stage of type-2 diabetes mellitus: (A) Decreased output of glucose from liver, (B) Increase in C-peptide, (C) Increase in GIP, (D) All of the above
Answer is C. Answer- C. Increase in GIPDuring the induction of insulin resistance,increased glucagon levels and increased glucose-dependent insulinotropic polypeptide (GIP) level accompany glucose intolerance. In the progression from normal to abnormal glucose tolerance, pospranadial blood glucose levels increase first. Eventually, fasting hyperglycemia develops as suppression of hepatic glconeogenesis fails.