Which antiepileptic drug does not act via inhibition of sodium channels?: (A) Vigabatrin, (B) Carbamazepine, (C) Lamotrigine, (D) Phenytoin
Answer is A. Ans. (A) Vigabatrin(Ref: KDT 8/e p448)Vigabatrin inhibits the metabolism of GABA by inhibition of GABA transaminase enzyme. It has no effect on Na+ channels.