Which chromosome mutation is associated with medulloblastoma?: (A) Chromosome 16, (B) Chromosome 17, (C) Chromosome 18, (D) Chromosome 19
Answer is B. Medulloblastoma can be subdivided into the following 4 groups: Group 3 medulloblastoma, often with MYC amplification and isochromosome 17 (i17q), tends to occur in infants and children, with a classic or large cell histology and the worst prognosis. Group 4 is characterized by an i17q cytogenetic alteration. IMG showing DROP METASTASIS i.e. metastasis occur by drop.