Steroids cause:: (A) Increased TSH, (B) Increased FSH, (C) Prevent de-iodination, (D) All of the above
Answer is C. Ans. (C) Prevent de-iodination(Ref: Katzung 11/e p670, 686)Glucocorticoids on long term use suppress the release of ACTH, GH, TSH and LH. These also inhibit the activity of 5'- deiodinase and thus inhibit the peripheral conversion of T4 to T3. These also decrease thyroid binding globulin.