Acetylcholine is not used commercially because:: (A) Long duration of action, (B) Costly, (C) rapidly destroyed in the body, (D) Crosses blood brain barrier
Answer is C. Ref:KD Tripathi pharmacology 7th edition (page.no: 99) ACh is hydrolyzed by the enzyme cholinesterase and choline is recycled. A specific (Acetylcholinesterase-AChE or true cholinesterase) and a nonspecific (Butyrylcholinesterase-BuChE or pseudocholinesterase) type of enzyme occur in the body. So Ach is rapidly destroyed in the body