Statin having longest half life:: (A) Rosuvastatin, (B) Pravastatin, (C) Simvastatin, (D) Lovastatin
Answer is A. Rosuvastatin It is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins. Its approximate elimination half life is 19 h and its time to peak plasma concentration is reached in 3-5 h following oral administration. REF : katzung pharmacology : 14th ed