Anticentromere antibodies are most commonly associated with:: (A) Diffuse cutaneous systemic sclerosis, (B) Mixed connective tissue disease, (C) CREST syndrome, (D) Polymyositis
Answer is C. Anti-centromere antibodies react with protein antigens located in the kinetochore region of chromosomes and are present in 40 to 80% of patients with limited cutaneous scleroderma or CREST syndrome. So CREST syndrome is the single best answer of choice. Ref: Harrisons Principles of Internal Medicine, 16th Edition, Pages 1979, 1986.