All are true about Hemolytic uremic syndrome except?: (A) Uremia, (B) Hypofibrinogenemia, (C) Thrombocytopenia, (D) Positive Coombs test
Answer is D. Positive Coombs test is seen with autoimmune hemolytic anemia but in H.U.S microangiopathic hemolytic anemia is seen. The entrapment of platelets in micro-thrombi formed in small blood vessels leads to thrombocytopenia. The consumption of clotting factors due to initiation of coagulation cascade leads to hypofibrinogenemia. Hemolytic uremic syndrome- characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure which explains uremia.