Drugs that have been found to be useful in compensated hea failure include all of the following except:: (A) Na+ K+ ATPase inhibitors, (B) Aldosterone antagonists, (C) BNP analogue, (D) Beta receptor antagonists
Answer is C. BNP analogue (Nesiritide) are used in acute cardiac failure not used in chronic therapy. Compensated hea failure (Chronic CHF): Management: Digitalis (Na+ - K+ ATPase inhibitor) - Inhibit Na+/K+ ATPase--> positive inotropic action. It does not acts as chronotropic agent so no increase in workload on hea and useful in chronic conditions. Aldosterone antagonist: Decreases morbidity/moality. Used to prevent cardiac remodelling along with ACE inhibitors and ARBs. b blockers: These drugs can precipitate acute decompensation of cardiac function but are used in chronic CHF as these decrease moality by reversing LVH.