A patient suffering from AIDS is on zidovudine, lamivudine and indinavir therapy. He develops pulmonary tuberculosis for which treatment is started. Which of the following should be avoided in him?: (A) INH, (B) Ethambutol, (C) Pyrazinamide, (D) Rifampicin
Answer is D. Ans. (D) Rifampicin(Ref: KDT 8th/e p818)Rifampicin is a powerful enzyme inducer. It increases the metabolism of protease inhibitors and thus decreases the efficacy of anti-retroviral therapy.Another drug, rifabutin is devoid of these interactions and is the preferred agent for treatment of mycobacterial infections in patients on anti-retroviral therapy.