Neurotoxicity is seen with excess of: (A) Vitamin B6, (B) Vitamin B12, (C) Vitamin B2, (D) Vitamin C
Answer is A. Neurotoxicity is seen with excess of Vit B6. Toxicity of pyridoxine: Pyridoxine is the only water-soluble vitamin with significant toxicity. Neurologic symptoms (sensory neuropathy) occur at intakes above 200 mg/day, an amount more than 100 times the RDA. Substantial improvement, but not complete recovery, occurs when the vitamin is discontinued. Reference: Lippincott Textbook of Biochemistry pg no. 378