Bleomycin toxicity affects which type of cells:: (A) Type-I pneumocytes, (B) Type-II pneumocytes, (C) Endothelial cells, (D) Pulmonary alveolar macrophages
Answer is A. Ans. (A) Type I pneumocytes(Oncologic Emergencies by Sai Citing p92)Bleomycin causes necrosis of Type I pneumocytes that results in compensatory hyperplasia of type-II pneumocytes. Same kind of injury can also occur in response to radiations. In experimental models, this type of injury has been ameliorated by keratinocyte growth factor.