If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is:: (A) 0.5 L/hr, (B) 2.0 L/hr, (C) 5.0 L/hr, (D) 20 L/hr
Answer is B. Ans. B. 2.0L/hra. Rate of elimination (RoE)- Amount of drug/timeb. Clearance (Cl):- rate of elimination/concentrationc. In the given MCQ, RoE=10mg/hr;Con=5mg/L,d. Therefore, Cl=10/5=2L/hr