Local anesthetic acts by:: (A) Blocking sodium gated channel, (B) Blocking calcium gated channel, (C) Blocking potassium gated channel, (D) Blocking chloride gated channel
Answer is A. NORMAL LOCAL ANESTHETIC Sodium passess through voltage gated sodium channel and cause change in membrane potential and cause depolarization. Local anesthetic attatches to sodium channel and prevents propogation & depolarization. LA also has mild action on potassium calcium and NMDA channels