Mechanism of action of zileuton:: (A) Inhibit prostaglandin synthesis, (B) Inhibit COX, (C) Inhibit LOX, (D) Inhibit mast cells
Answer is C. Ans. C. Inhibit LOXArachidonic acid is acted upon by two enzyme-COX and LOX. Lox converts it into leukotrienes and Cox into prostaglandin. Zileuton is the inhibitor of LOX enzyme and it is used in treatment of asthma.