Which of the following is the most beta-1 selective antagonist?: (A) Acebutolol, (B) Atenolol, (C) Metoprolol, (D) Bisoprolol
Answer is D. Ans: D (Bisoprolol) Ref: Goodman & Gill man's The Pharmacological Basis of Therapeutics. 2011, 12th Edition, McGraw-Hill, Burton LL P 328Explanation:Bisoprolol is highly selective beta-1 selective antagonist among the given drugsHowever nehivolol has higher beta-1 selective antagonist than bisoprololBeta-1 selective antagonist includeAcebutololAtenololBetaxololBisoprololCeliprololEsmololMetoprololNebivolol