Which of the following is the best marker for drug induced lupus?: (A) Anti histone antibodies, (B) Anti DS DNA, (C) ANA, (D) Anti Smith Ab
Answer is A. Drug induced lupus is associated with anti histone antibodies which are positive in 95% of cases. Ref: Harrison's Principles of Internal Medicine, 17th Edition, Page 2076; 16th/ 1961, 1967; Pathologic Basis of Disease, Robbins, 7th Edition, Page 229 & 235; Drug-Induced Diseases: Prevention, Detection, and Management, James E. Tisdale, 2nd Edition, Section 2, Page 108