Which of the following subtype has the strongest association with HIV in Hodgkin lymphoma ?: (A) Lymphocyte-rich, (B) Lymphocyte-depleted, (C) Nodular lymphocyte-predominant, (D) Nodular sclerosis
Answer is B. Lymphocyte-depleted Hodgkin lymphoma : It has the strongest association with the HIV. Lymphocyte depletion Hodgkin lymphoma occurs predominantly in older adults, in HIV-positive individuals of any age Least common subtype of HL Diffuse subtype of classic Hodgkin lymphoma (CHL) rich in Hodgkin Reed-Sternberg (HRS) cells or depleted in non-neoplastic lymphocytes. Advanced stage and systemic symptoms are frequent Worst Prognosis.