Which of the following is the most important mediator implicated in development of fever:: (A) PGF2, (B) PGE2, (C) PGD2, (D) FGA2
Answer is B. PGF2α is a vasoconstrictor whereas PGD2 and PGE2 are vasodilators. 
PGE2 is the most important chemical for development of fever.