Drugs which affect DNA synthesis or replication are all except:-: (A) 5-FU, (B) Bevacizumab, (C) Doxorubicin, (D) Methotrexate
Answer is B. Bevacizumab is a monoclonal antibody against VEGF. It acts by inhibiting angiogenesis. Doxorubicin is a topoisomerase inhibitor and inhibit the uncoiling of DNA and thus replication. 5-FU is a pyrimidine analog and inhibit DNA synthesis by competing with DNA polymerase. Methotrexate is a dihydro folic acid reductase inhibitor. It decreases the formation of DNA.