Which drug is not included in RNTCP regime for MDR TB -: (A) Cycloserine, (B) Ethionamide, (C) Levofloxacin, (D) PAS
Answer is D. Ans. is 'd' i.e., PAS Treatment of multidrug resistance (MDR) TBo MDR-TB is defined as resistance to at least both IIS H and rifampicin. Previously it was classified as Category IV under DOTS (DOTS-PLUS).o The treatment is given in two phases, the intestive phase (IP) and the continuation phase (CP). The total duration of treatment for regimen for MDR-TB is 24-27 months, depending on the IP duration,o Treatment regimen comprises :-Intensive phase (6-9 months) : Six drugs : Kanamycin (Km), levofloxacin (Lvx), ethionamide (Eto), pyrazinamide (Z), ethambutol (E), and cycloserine (Cs).Continuation phase (18 months) : Four drugs : Levofloxaxcin, ethionamide, ethambutol and cycloserine,o Total duration of treatment is 24-27 months.Treatment of extensive drug resistance (XDR) TBo XDR-TB is defined as resistance to any fluoroquinolone and at least one of the following three second-line drugs (capreomycin, kanamycin, amikacin), in addition to muitidrug resistance,o The Regimen for XDR-TB w'ould be of 24-30 months duration, with 6-12 months Intensive Phase (IP) and 18 months Continuation Phase (CP).o Regimen is :-Intensive phase (6-12 months) : Seven drugs : Capreomycin, PAS, moxifloxacin. high dose INH. clofazimine, Linezolid, amoxyclav.Continuation phase (18 months) : Six drugs : PAS, moxifloxacin, high dose INH, clofazimine, linezolid, amoxyclav.