Which of following HMG CoA reductase inhibitor has longest half life?: (A) Atorvastatin, (B) Simvastatin, (C) Rosuvastatin, (D) Pitavastatin
Answer is C. Rosuvastatin - Longest acting Pitavastatin - most potent - Statins have maximum LDL lowering capacity. - Given at night because HMG CoA reductase is maximum active at night but Atorvastatin and Rosuvastatin are long acting drugs, thus can be given any time of the day. - Statins can cause myopathy