Commonest presentation of sickle cell anaemia is: (A) Priapism, (B) Bone pain, (C) Fever, (D) Splenomegaly
Answer is B. Sickle cell anemis causes Vaso-occlusive crisis : This means plugging of small vessels in the bone produces severe bone pain. This affects areas of active marrow: the hands and feets in children(dactylitis) or femora, humeri, ribs, pelvis and veebrae in adults. Reference : Davidson, 23rd Edition, page no : 952.