Febrile response in CNS is mediated by: (A) Bacterial toxin, (B) IL1, (C) IL6, (D) Interferon
Answer is A. ref Harrison 18/e 143p -145 Fever is produced in response to substance called pyrogens that acts by stimulating prostaglandins synthesis in vascular and periferal cells of hypothalamus.there are exogenous and endogenous pyogens