40 year-old immunocompromized came with C/o dysphagia.  UGI scopy showed multiple ulcers in the distal esophagus.  Biopsy from the esophagus showed the following.  What is the diagnosis?: (A) Candia, (B) Cytomegalovirus, (C) Herpes, (D) Eosinophilic esophagitis
Answer is B. Ref. Robbins Pathology 9th edition, page. 280
 
Lets see it one by one
To solve -

Candida – No whitish discharge – No spore on microscopy – Ruled out
Herpes – Yes can produce multiple ulcers, but herpes will have multinucleation and groud glass eosinophilic inclusion – Ruled out
Eosinophilic esophagitis – You are not seeing classical clusters of eosinophil
CMV – intranuuclear blue inclusions – yes, immunocompromised person, yes.