Indomethacin reduce the diuretic action of furosemide by: (A) Preventing prostaglandin mediated heamodynamic actions, (B) Blockade of furosemide action in loop of henle, (C) Enhancing water reabsorption in distal tubule, (D) Increasing aldosterone secretion
Answer is A. NSAIDS inhibit specifically PGE2, PGI2 synthesis in renal tubules effecting the hemodynamic changes done by Prostaglandins for water, sodium reabsorption Ref: katzung 12th ed, Autocoids.