Which antihypeensive is a prodrug and is conveed to its active form in brain?: (A) Clonidine, (B) Methyl dopa, (C) Minoxidil, (D) Nitroprusside
Answer is B. Both methyldopa and minoxidil are prodrugs. Conversion of methyl dopa to a-methylnorepinephrine takes palce in the brain. Minoxidil is activated to minoxidil sulphate (by phase II reaction) in the periphery.