Which of the following is the commonest genetic mutation in a 50 year old obese female presenting with postmenopausal bleeding and diagnosed with endometrial cancer?: (A) P53, (B) PTEN, (C) CHD4, (D) Beta catenin
Answer is B. 50 year old obese female with endometrial cancer most likely to be type I Endometrial cancer rather than type II which happens in elderly female >65yrs. Type I Type II - 55-56 yo - Endometroid - Hyperplasia - Indolent - PTEN Genetic Mutation - 65-75 yo. - Clear cell serous - Atrophy - Aggressive - P 53 gene mutation