Most common porphyria in humans is due to deficiency of which of the following enzyme:: (A) PBG deaminase, (B) Uroporphyrinogen decarboxylase, (C) Ferrochelatase, (D) Coproporphyrinogen oxidase
Answer is B. Porphyria Cutanea Tarda is the most common porphyria. Enzyme defect:- Uroporphyrinogen decarboxylase Sporadic (type 1) Familial (type 2) Can also develop after exposure to halogenated aromatic hydrocarbons. MC Acute porphyria - Acute intermittent porphyria MC porphyria in children - Erythropoietic protoporphyria