Cyclin D1 translocation is seen in
?: (A) Follicular lymphoma, (B) Mantle cell lymphoma, (C) Hodgkin lymphoma, (D) Melanoma
Answer is B. Mantle cell lymphoma is characterized by t(11,14) it places the cyclin D1 gene next to IgH enhancer gene. Among lymphomas, cyclin D1 expression is very specific for Mantle cell lymphoma.