A 45 year old female was diagnosed with breast carcinoma. She was operated and is taking tamoxifen therapy for the last 1 year. Now she is complaining of bleeding per vaginum. If this is due to the adverse effect of tamoxifen, the most likely cause is:-: (A) Development of bleeding disorder, (B) Development of endometrial carcinoma, (C) Development of ovarian carcinoma, (D) Development of cervical cancer
Answer is B. - Tamoxifen and Toremifene are selective estrogen receptor modulators (SERMs) that are useful for chemoprevention as well as treatment of both early stage and metastatic breast carcinoma. - These increase the risk of endometrial carcinoma.