Sulfonylureas act by:: (A) Decreasing glucagon secretion from pancreas, (B) Decreasing insulin secretion from pancreas, (C) Increasing gluconeogenesis, (D) Increasing insulin secretion from pancreas
Answer is D. Ans. (D) Increasing insulin secretion from pancreas(Ref: KDT 8/e p294)Sulfonylureas stimulate the release of insulin by the beta cells of the islets of Langerhans by blocking K+ channels. Glucagon secretion is also reduced by sulfonylureas, but it is a minor action.