Retinoblastoma gene is located on:: (A) Chromosome 5, (B) Chromosome 8, (C) Chromosome 13, (D) Chromosome 16
Answer is C. c. Chromosome 13(Ref: Nelson's 20/e p 2476-2478, Ghai 8/e 614-615)Retinoblastoma (RB) geneIt is located on chr 13q14; its mutation or deletion is responsible for hereditary form of RetinoblastomaIt encodes the retinoblastoma protein, a tumor suppressor protein that controls cell-cycle phase transition and has roles in apoptosis and cell differentiation