A young male presents with meningococcal meningitis and allergy to penicillin. Which is the most suitable drug?: (A) Chloramphenicol, (B) Meropenem, (C) Ciprofloxacin, (D) Teicoplanin
Answer is A. Chloramphenicol which is bactericidal to meningococci can achieve high concentration in the CSF, so useful in the treatment of meningococcal meningitis in penicillin resistant individuals. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 674 - 5; Principles And Practice of Clinical Bacteriology By Stephen H. Gillespi, 2nd Edition, Page 215.