Tangier disease is characterised by which of the following lipid abnormalities?: (A) Extremely low circulating level of plasma cholesterol, (B) Low level of LDL but high HDL level, (C) Extremely low level of triglycerides, (D) Very high level of triglycerides
Answer is A. Tangier disease is a very rare autosomal dominant form of extremely low plasma HDL-Cholesterol caused by mutations in the gene encoding ABCA1. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 3154