Leptocyte in blood smears seen in?: (A) Sickle cell anemia, (B) Thalassemia, (C) Post splenectomy, (D) Uremia
Answer is B. Ans. (b) Thalassemia(Ref: Robbins 9th/pg 649-652)Leptocytes are flattened red cells in which the volume-to- surface area ratio is decreased. Seen in iron deficiency anemia and thalassemia in which the red cells with a low mean cell hemoglobin (MCH) and mean cell volume (MCV) are unusually resistant to osmotic lysis.