In renal failure, metabolic acidosis is due to ?: (A) Increased H" production, (B) Loss of HCOf, (C) Decreased ammonia synthesis, (D) Use of diuretics
Answer is C. Ans. is 'c' i.e., Decreased ammonia synthesis The predominant reason for metabolic acidosis in C.R.F. is decreased ammonia production.o Metabolic acidosis is a common disturbance in advanced chronic kidney' disease# The majority of patients can still acidly the urine but they'produce less ammonia and, therefore, cannot excrete the normal quantity of protons in combination with this urinary* buffer.