Characteristic feature of Goodpasture's syndrome: (A) Lumpy-bumpy deposits on immunofluorescence, (B) Serum antibodies against alpha 3 NC1 domain of collagen - IV, (C) Serum antibodies against alpha 1 NCI domain of collagen III, (D) Anti DNAse antibodies positive
Answer is B. Ans. (b) Serum antibodies against alpha 3 NC1 domain of collagen - IV(Ref: Robbins 9th/pg 912-913)Goodpasture syndromeIt is type 1 RPGN & a type II hypersensitivity reaction.It is characterized by serum antibodies against alpha 3 NC1 domain of collagen - IV.This shows linear GBM fluorescence, while all other Glomerulonephritis, which are type 3 Hypersensitivity reactions show granular immune deposits.