DNA supercoiling is done by: (A) DNA polymerase I, (B) DNA polymerase II, (C) DNA polymerase III, (D) DNA topoisomerase
Answer is D. Enzymes that catalyze topologic changes of DNA are called topoisomerases. Topoisomerases can relax or inse supercoils, using ATP as an energy source. DNA gyrase is a type of topoisomerase Harper30e pg: 362