The finnish type of congenital nephritic syndrome occurs due to gene mutation affecting the following protein -: (A) Podocin, (B) Alpha-actinin, (C) Nephrin, (D) CD2 activated protein
Answer is C. Ans. is 'c' i.e., Nephrin Congenital nephrotic syndrome o Infant who develop nephrotic syndrome within the first 3 months of life are considered to have congenital nephrotic syndrome. o The most common cause of this syndrome is finnish-type congenital nephrotic syndrome, an autosomal recessive disorder. o Two most common genes involved are - i) NPHS1--> Coding for nephrin and results in finnish-type nephrotic syndrome. ii) NPHS2 --> Coding for Podocin and results in FSGS.