Regarding phenytoin, false is:: (A) Induces microsomal enzymes, (B) At very low doses, zero order kinetics occur, (C) Higher the dose, higher is the half life, (D) Highly protein bound
Answer is B. *Phenytoin follows saturation kinetics (kinetics changes from first order to zero within therapeutic concentration), Zero order kinetics are seen at high doses. *It is also a potent enzyme inducer and can increase the metabolism of various drugs. *It is 80-90% plasma protein bound. REF: KATZUNG 14TH ED.