Cryosurgery is used in treatment of cervical intraepithelial neoplasia. It is appropriate in all except: (A) Transformation zone lying entirely on ectocervix., (B) Smooth cervical surface without deep crevices., (C) Cervical intraepithelial neoplasia -3., (D) CIN limited to two quadrants of the cervix.
Answer is C. Cryosurgery is generally not favoured for treatment of CIN-3 due to higher rates of disease persistence following treatment, and lack of histologic specimen to exclude occult invasive cancer.