All of the following statements about mycophenolate mofetil are true except :: (A) It is a prodrug, (B) Gastrointestinal toxicity is common, (C) It is used in transplant recipients where other drugs are not effective, (D) It is highly nephrotoxic
Answer is D. Mycophenolate mofetil is a prodrug, its active metabolite is mycophenolic acid.
It is used as an immunosuppressant drug in solid organ transplant patients for refractory rejection and as an alterna­tive to cyclosporine /tacrolimus in patients who do not tolerate these drugs.

- Major toxicity is gastrointestinal (nausea, vomiting, diarrhea, abdominal pain). It can also cause hypertension and reversible neutropenia.
- Unlike cyclosporine and tacrolimus, it does not cause nephrotoxicity.