All of the following are causes of primary amenorrhea, EXCEPT:: (A) Rokitansky syndrome, (B) Sheehan syndrome, (C) Kollman syndrome, (D) Turner syndrome
Answer is B. Sheehan's syndrome, characterized by postpaum amenorrhea, results from postpaum pituitary necrosis secondary to severe hemorrhage and hypotension and is a rare cause of secondary amenorrhea. Mullerian agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome) is the second most common cause of primary amenorrhea. Kallmann syndrome results from defective hypothalamic gonadotropin-releasing hormone (GnRH) synthesis and is associated with anosmia or hyposmia due to olfactory bulb agenesis or hypoplasia. It is a cause of primary amenorrhea. Patients with Turner's syndrome usually present with primary amenorrhea. Must know: Causes of Secondary Amenorrhea: Common: Pregnancy Hypothalamic amenorrhea Pituitary amenorrhea Androgen disorders: polycystic ovarian syndrome, adult-onset adrenal hyperplasia Galactorrhea-amenorrhea syndrome Less Common: Premature ovarian failure Asherman's syndrome Sheehan's syndrome Drug-induced amenorrhea Rare: Diabetes Hypehyroidism or hypothyroidism Cushing's syndrome or Addison's disease Cirrhosis Infection Malnutrition Irradiation or chemotherapy Hemosiderosis Ref: Simon A., Chang W.Y., DeCherney A.H. (2013). Chapter 54. Amenorrhea. In A.H. DeCherney, L. Nathan, N. Laufer, A.S. Roman (Eds), CURRENT Diagnosis & Treatment: Obstetrics & Gynecology, 11e.