Gp deficiency is seen in -: (A) Glanzmann's thrombasthenia, (B) Bemard-Soulier syndrome, (C) Platelet storage pool disorders, (D) GPillb
Answer is A. Answer is option 1 Glanzmann's thrombasthenia is an abnormality of the platelets. It is an extremely rare coagulopathy (bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged. Ref Robbins 9/e pg 450