Bullous disease in which autoantibodies are formed against antigens of epidermal intercellular junctions: (A) Pemphigus Vulgaris, (B) Epidermolysis bullosa, (C) Dermatitis herpatitis, (D) Bullous pemphigoid
Answer is A. Bulla development in pemphigus vulgaris is due to Acantholysis, this is disruption of intercellular attachment leading to intraepidermal bullae. Autoantibodies against desmosomal protein-desmoglein-3 mediate the pathogeneis.