Botulinum toxin produces skeletal muscle paralysis by:: (A) Enhancing release of norepinephrine, (B) Inhibiting release of acetylcholine, (C) Direct damage to nerve endings, (D) Producing hemolysis
Answer is B. Ref: KD Tripathi pharmacology 7th edition (page.no: 99) Botulinum toxin A and B are highly potent exotoxins produced by Clostridium botulinum that is responsible for Botulism. These neurotoxic proteins cause long-lasting loss of cholinergic transmission by interacting with an axonal protein involved in the exocytic release of Ach