Drug causing decrease in late sodium current -: (A) Nicorandil, (B) Ranolazine, (C) Trimetazidine, (D) Molsidominc
Answer is B. Ans. is 'b' i.e., Ranolazine o Ranolazine was initially assigned as paial fatty acid oxidation inhibitors. However, now it is believed that it acts by a different mechanism. It acts by blocking a late sodium current that facilitates calcium NCX (Sodium -Calcium exchanger) -4 Calcium overload and decrease left ventricular wall tension --> decreased myocardial oxygen demand.