Lowe's syndrome is characterised by the following except –: (A) Hypophosphatamic rickets, (B) Undescended testes, (C) Defect in the CNS and eyes, (D) Aminoaciduria
Answer is B. Lowe's syndrome

It is also known as an oculocerebrorenal syndrome of Lowe.
It is an X-linked disorder.
It is characterized by :

i) Congenital cataract
ii) Mental retardation
iii) Fanconi syndrome → Aminoaciduria

The disease is caused by a mutation in the OCRL1 gene, which encodes the phosphatidylinosital polyphosphate 5-phasphatasq.

Clinical features

Progressive growth failure o Hypotonia                               
Blindness    
Fanconi syndrome    
Renal inefficiency      
Behavioural problems   
Significant proteinuria