Which of the following statements is not true of local anesthetics?: (A) The local anesthetic is required in the unionized form for penetrating the neuronal membrane, (B) The local anesthetic approaches its receptor only from the intraneuronal face of the Na+ channel, (C) The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state, (D) The local anesthetic combines with its receptor in the ionized cationic form
Answer is C. None