True about Alphal antitrypsin deficiency is?: (A) Deficiency of protease inhibitor, (B) Autosomal recessive, (C) May cause cholestatic jaundice, (D) All of the above
Answer is D. ANSWER: (D) All of the aboveREF: Robbins 7th ed p. 913Alpha 1 antitrypsin deficiency:Due to protease inhibitor deficiencyIncreased neutrophill elastaseNeonatal cholestasis may occur,Hepatocellular carcinoma may also developPulmonary disease may occur in form of emphysemaGene located on chromosome 14