Mechanism of action of furosemide as a diuretic is:-: (A) Inhibition of Na-K-Cl ion sympoer, (B) Aldosterone antagonism, (C) Inhibition of Na-Cl sympoer in distal tubules, (D) Carbonic anhydrase inhibition
Answer is A. Name Site of action Example Mechanism Loop diuretics Thick ascending limb of Loop of Henle Furosemide, Torsemide Na-K-2Cl sympoer inhibition Carbonic anhydrase inhibitors PCT Acetazolamide, Dorzolamide, Brinzolamide Carbonic anhydrase inhibition Thiazides DCT Hydrochlohiazide, Chlohalidone Na-Cl sympoer inhibition Osmotic diuretics Non-specific Mannitol By osmotic effect Epithelial sodium channel blockers Collecting duct Amiloride, Triamterene eNa channel blockade Aldosterone antagonists Collecting duct Spironolactone, Epleronone Antagonism of aldosterone receptors