Which of the following changes in C-MYC oncogene may be associated with colonic malignancy?: (A) Point mutation, (B) Amplification, (C) Rearrangement, (D) Deletion
Answer is B. C- MYC amplification may be responsible for Ca breast, Ca colon, Ca stomach and lung. L - MYC amplification is associated with Ca lung and bladder. N- MYC amplification is associated with neuroblastoma and Ca lung. Ref: Harrison, 17th Edition, Page 496