Infliximab is directed against -: (A) Tumor necrosis factor-a (TNF - a), (B) Interleukin-1 (IL-1), (C) Interleukin -12 (IL -12), (D) Intercellular adhesion molecule (ICAM)
Answer is A. TNF-alfa (alpha) inhibitors (TNF-alpha) are a group of medicines that suppress the body's natural response to tumor necrosis factor (TNF), a protein produced by white blood cells that is involved in early inflammatory events. TNF-alfa inhibitors treat a wide range of inflammatory conditions such as RA , juvenile ahritis, crohn's disease, ulcerative colitis , ankylosing spondolytis, and psoriasis . Ref - Tripati 7th edition , Pubmed.com