Wigabatrin' a new antiepileptic agent acts by ?: (A) GABA- antagonis, (B) GABA - agonism, (C) NMDA antagonism, (D) Carbonic anhydrase inhibition
Answer is B. Ans is 'b' i.e., GABA-agonism o Vigabatrin (y-vinyl GABA) is an inhibitor of GABA transaminase, the enzyme which degrades GABA. o Anticonvulsant action is due to increase synaptic GABA concentration.