What is the defect in Dubin Johnson syndrome: (A) Mutation in ATP7B gene, (B) Mutation in MRP - 2 gene, (C) Mutation in UGT1A1 gene, (D) Mutation in ATP7A gebe
Answer is B. In Dubin Johnson syndrome these is impaired biliary excretion of bilirubin glucuronides due to mutation in canalicular multidrug Resistance Protein -2 (MRP- 2).