To rule out rheumatoid arthrirtis, most important among the followings is?: (A) HLA DR8, (B) HLA DR4, (C) HLA DQ1, (D) HLA B27
Answer is B. Ans. is 'b' i.e., HLA-DR4 o DR4 is strongly associated with RA(also with Type 1 DM Pemphigus vulgaris).Other optionso HLA-B27 is associated with seronegative spondyloartropathies (ankylosing spondylitis, Psoriatic arthritis, Reiter's syndrome, reactive arthritis) and acute anterior uveitis o HLA DR8 is associated with Type 1 DM.o HLA DQ1 is associated with pemphigus vulgaris.