In primary immune deficiency, the following plasma protein fraction is reduced -: (A) alpha-1 globulin, (B) Alpha 2 globulin, (C) Beta globulin, (D) Gamma-globulin
Answer is D. Hypogammaglobulinemia is characterized by a decrease in the g component. It is seen in congenital immune deficiency syndromes or in association with diseases such as nephrotic syndrome, chronic lymphocytic leukemia, and coicosteroid treatment . Ref - Davidson 23rd edition pg 1063b