Delayed prolonged bleeding is caused by: (A) Histamine, (B) Leukocyte dependent injury, (C) IL-I, (D) Direct injury to endothelial cells
Answer is D. EndotheliumDirect injury to endothelial cells causes delayed prolonged bleeding because, endothelial cells are central regulators of hemostasis, the balance between the anti-and prothrombotic activities of endothelium determines whether thrombus formation, propagation or dissolution occurs.Robbins basic pathology 9th edition page no 79