Multiple sinuses from infection of great toe is mainly caused by: September 2007: (A) Tuberculosis, (B) Actinomycetes, (C) Trichosporum, (D) Histoplasmosis
Answer is B. Ans. B: Actinomycetes Mycetoma is a chronic localized granulomatous inflammatory lesion common in the tropics and sub-tropics. Multiple siAuses, soft tissue swelling and discharge of coloured granules characterize a mycetoma foot. Chronic sinuses discharging granules are caused by (1) Eumycetes (true fungi), (2) Schizomycetes, which includes Actinomycosis (aerobic higher filamentous bacteria) and Botryomycosis (bacterial infection). - Actinomycosis is often caused by Actinomadura or Nocardia species wherein it gains entry after penetrating trauma (splinter, gravel or thorn prick). Young males are commonly affected and 75% of the lesions occur in the lower limbs. The disease slowly progresses from a nodule to multiple sinuses discharging coloured granules. Involvement of bone is late following dermal and soft tissue spread. - Botryomycosis (a misnomer), a chronic suppurative infection is caused by bacteria involving skin or viscera . This rare condition mimics a deep mycotic infection and is often caused by Staphylococcus or Pseudomonas species of bacteria. The feet and hands are commonly affected and penetrating trauma may be a predisposing factor. It usually presents as a nodule, sinus or ulcer, which is initially localized. The diagnosis of actinomycosis is based on clinical findings, demonstration of characteristic granules and culture of the organism from a deep tissue biopsy. Immunological studies (counter immuno electrophoresis and ELISA) are also used. Botryomycosis is diagnosed based on a positive gram's stain and culture; negative fungal cultures and demonstration of the characteristic botryomycotic granules at histopathology from a deep biopsy. In endemic areas, subcutaneous swelling with sinuses should be considered as mycetoma unless proved otherwise. The differential diagnosis includes chronic osteomyelitis, tuberculosis and chronic abscesses.