Which of the following agents enhances the bioavailability of levodopa in patients with Parkinson's disease :: (A) Amantadine, (B) Ropinirole, (C) Entacapone, (D) Selegiline
Answer is C. Levodopa metabolized in the body by two enzymes; MAO and COMT. Thus MAO inhibitors like selegiline and COMT inhibitors like entacapone and tolcapone can increase the bioavailability of dopa.