Which is the drug of choice in Paget's disease?: (A) Alendronate, (B) Steroids, (C) Allopurinol, (D) Calcitonin
Answer is A. Treatment of Paget's disease Mithramycin (Plicamycin), an anti-neoplastic agent (toxic to osteoclast) was the first drug used for paget's disease. DOC is Bisphosphonates - Etidronate was used first, Alendronate , Risedronate is preferred now. Calcitonin is used for acute relief of pain(temporary effect).