Which is not cytogenetic abnormality in myclodysplastic syndrome: (A) Chromosome 5q deletion, (B) Monosomy 7, (C) Trisomy 8, (D) Chromosome 20q deletion
Answer is D. Solution:
Adult → 5q deletion
Pediatric → monosomy 7
Trisomy 8 → 3 copies of MYC gene
These three are common genetic defects of MDS.