Syndrome of apparent mineralocoicoid excess is due to?: (A) Increased aldosterone production, (B) Lack of inactivation of aldosterone, (C) Increased coisol production, (D) Lack of Inactivation of coisol to coisone
Answer is D. Coisol can stimulate mineralocoicoid receptors. But renal inactivation of coisol occurs to form coisone and thereby BP remains normal. SAME (Syndrome of Apparent Mineralocoicoid Excess) leads to lack of this inactivation. The resultant increase in coisol leads to excess activation of mineralocoicoid receptor and results in hypeension.