E6 gene product of HPV causes malignance transformation by acting on ?: (A) p53 gene, (B) RAS gene, (C) C-myc gene, (D) N-myc gene
Answer is A. Ans. is 'a' i.e., p-53 gene HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia.Products of E-genes (E6, E7) are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively.