Most common cause of ambigious genitalia in a female child is:: (A) Placenta steroid sulfatase deficiency, (B) Fetal aromatase deficiency, (C) Wnt4 mutation, (D) Congenital adrenal hyperplasia
Answer is D. “CAH due to 21 hydroxylase deficiency is the most frequent cause of sexual ambiguity and the M/C endocrine cause of neonatal death.”
Ambiguity of sex at birth—"Cases of ambiguity of sex detected at birth are due to adrenogenital syndrome unless proved otherwise".