Syndrome associated with increased risk of leukemia is:: (A) Plummer Vinson syndrome, (B) Klinefelter syndrome, (C) Sturge Weber syndrome, (D) Multiple hamartoma sydrome
Answer is B. Genetic disease association of Lympho-haematopoietic malignancies:
Acute leukaemia occurs with increased frequency with a variety of congenital disorders such as:

Down’s syndrome
Bloom’s syndrome
Klinefelter’s syndrome
Wiskott-Aldrich’s syndrome

Mohan H. Textbook of pathology. Jaypee Brothers Medical Publishers; 2015. Edition 7. Page 334