Which of the following is the most common mutation in Ewing's sarcoma -: (A) Translocation X : 18, (B) Translocation 11; 22, (C) Activative mutation of G5alpha surface protein, (D) Missense mutation in EXTI
Answer is B. Ewing's sarcoma is typically characterized by a translocation t (11; 22) (q 24; q12) in up to 90% of patients.