Which of the following is most strongly associated with pathogenesis of Psoriasis:: (A) Th16, (B) Th1, (C) Th2, (D) Th17
Answer is D. PSORIASIS Lesions are characterized by infiltration of skin with activated T cells, which have a role in the pathophysiology of psoriasis (cytokines stimulate keratinocyte hyperproliferation). Earlier it was considered that Th1 cells(CD8+) plays most imp. role in pathogenesis, but now Th17 is considered most imp. in pathogenesis, induced by IL-23. Is linked to HLA-Cw6 and, to a lesser extent, to HLA-DR7. Psoriatic ahritis is associated with HLA- B27