Resistance to methicllin is acquired by:: (A) Increased B-lactamase production, (B) Induction of channels that pump out the drug, (C) Alteration in penicillin binding protein, (D) Decreased absorption of drug in the gut
Answer is C. Methicillin, Nefcillin, oxacillin are B lactamse resistant penicillins. Resistance can occur only if there is alteration of penicillin binding protein.