The recently approved antiepileptic drug lacosamide acts by:: (A) Inhibiting synaptic vesicular protein, (B) Inhibing CRMP protine, (C) Inhibing GABA metabolism, (D) Inhibing glutamate release
Answer is B. (Ref: Katzung, 14th ed. pg. 417)* CRMP is Collapsing Response Mediator Protein, which causes neuronal excitotoxicity by releasing BDNF (Brain Derived Neurotropic Factor).* The drug Lacosamide acts by inhibiting CRMP protein, thereby causing protective action against neuronal excitotoxicity.