All of the following statements regarding theophylline are true except:: (A) Increases cAMP, (B) Inhibits phosphodiesterase, (C) Increase in dose is required in smokers, (D) Increase in dose is required in cardiopulmonary disease
Answer is D. Theophylline is a methylxanthine , used in the treatment of bronchial asthma. Its dose has to be reduced in elderly (age > 60years), in congestive hea failure, pneumonia and liver failure. Ref: Essentials of Medical Pharmacology, 5th Edition, Page 203