All of the following statements about vinristine are true EXCEPT:: (A) It acts by inhibiting mitosis, (B) Its prominent adverse effect is peripheral neuropathy, (C) It does not suppress bone marrow, (D) It is a drug of choice for solid tumors.
Answer is D. (Ref: KDT 6/e p824, 825) Vincristine is a vinca alkaloid. It acts in M-phase of cell cycle by inhibiting the formation of spindle. It is a marrow sparing drug and causes peripheral neuropathy as a prominent adverse effect. It is used for the treatment of hematological malignancies like Hodgkin's lymphoma and leukemias. It is ineffective against solid tumors.