The following statements are true regarding neutrophil extracellular trap: (A) Produced by neutrophils in response to infectious pathogens and inflammatory mediators, (B) Provide a high concentration of antimicrobial substances at sites of infection, (C) Prevent the spread of the microbes by trapping them in the fibrils, (D) All the above
Answer is D. Ans. (d) All the above(Ref: Robbins 9th/pg 81)Neutrophil extracellular traps (NETs) are extracellular fibrillar networks that provide a high concentration of antimicrobial substances at sites of infection and prevent the spread of the microbes by trapping them in the fibrils. They consist of a viscous meshwork of nuclear chromatin that binds and concentrates granule proteins such as antimicrobial peptides and enzymes