Long term use of aspirin in rheumatoid ahritis is limited by its propensity to cause:: (A) Metabolic acidosis, (B) Hypersensitivity reactions, (C) Gastric mucosal damage, (D) Salicylism
Answer is C. All non-selective COX inhibitors including aspirin on long-term used can cause gastric toxicity ranging from gastritis to peptic ulcer. Selective COX-2 inhibitors have lesser propensity to cause this adverse effect. Salicylism and metabolic acidosis are seen in overdose, not with long term use.