Sections from a solid-cystic unilateral ovarian tumor in a 30-year old female show a tumor composed of diffuse sheets of small cells with doubtful nuclear grooving and scanty cytoplasm. No C -Exner bodies are seen. The ideal immunohistochemistry panel would include -: (A) Vimentin, epithelial membrane antigen, inhibin, CD99, (B) Desmin, S-100 protein, smooth muscle antigen, cytokeratin, (C) Chromogranin, CD45, CD99, CD20, (D) CD3, chromagranin, CD 45, synaptophysin
Answer is A. This patient is having granulosa cell tumor of the ovary which is characterized histologically by :

Diffuse sheets of round and oval cells     
Inconspicuous groove and folds in nuclei - coffee bean appearance
Scant cytoplasm


Granulosa cell tumor is positive for →

(i) Vimentin, (ii) Inhibin, (iii) CD99

Epithelial membrane antigen is positive in surface epithelial tumor.