Inhibition of which of the following enzyme is responsible for the anticancer action of 5-Fluorouracil ?: (A) Dihydrofolate reductase, (B) Thymidylate kinase, (C) Thymidylate reductase, (D) Thymidylate synthase
Answer is D. Drugs Inhibitor of 5-Fluorouracil thymidylate synthase(Suicidal inhibition) Methotrexate Dihydrofolate reductase Acyclovir thymidylate kinase