13-year-old female child presented with recurrent sinusitis fever, ahralgia, respiratory distress, Hematuria and hypeension. Renal biopsy showed necrotizing granuloma. The anti proteinase-3 ANCA was positive. The most likely diagnosis is:: (A) Polyaeritis Nodosa, (B) Wegener's granulomatosis, (C) Microscopic polyangiitis, (D) Churg-Strauss syndrome
Answer is B. Respiratory & Renal involvement along with positive c-ANCA (Anti Proteinase 3) indicates Wegener's Granulomatosis