What is the best time to give oral psoralen with UVA -: (A) Half hour before UVA, (B) 1 hour before UVA, (C) Half n hour after UVA, (D) 1 hour after UVA
Answer is B. Ans is 'b' i.e. 1 hour before UVA Oral PUVAo In oral PUVA, 8-MOP is administered orally (0.6 -0.8 mg/kg body weight) 1 -3 hours before exposureo For 5-MOP the usual dose is 1.2-1.8 mg/kg body weight.Topical PUVAo A lotion containing 0.1-1 % 8-MOP is applied on the affected area and is exposed to UVA either immediately or after 1 - 2 hours.o Alternatively, a vanishing cream containing 0.01% TMP is applied 10-20 minutes before exposure.