Regarding leprosy true is: (A) Lives in parts of body where temperature is <37 degrees, (B) Can grow in cell free culture media, (C) Can be seen in biopsies in tuberculoid leprosy, (D) Sensitive to INH and Rifampicin
Answer is D. (D) Sensitive to INH and Rifampicin # LEPROSY, is a nonfatal ] chronic infectious disease caused by Mycobacterium leprae: the clinical manifestations of which are largely confined to the skinL peripheral nervous system 3 upper respiratory tract, eyes, and testis.> M. leprae remains one of the few bacterial species that still has not been cultivated on artificial medium or tissue culture.The multiplication of M. leprae in mouse footpads.> AFB are generally absent or few in number in tuberculoid leprosy.> WHO recommends that pauci bacillary adults be treated with 100 mg of dapsone daily and 600 mg of rifampin monthly (supervised) for 6 months.> Multibacillary adults should be treated with 100 mg of dapsone plus 50 mg of clofazimine daily (unsupervised) and with 600 mg of rifampin plus 300 mg of clofazimine monthly (supervised).> WHO recommended that lepromatous patients be treated for 2 years or until smears became negative (generally in -5 years); subsequently the acceptable course was reduced to 1 year.