Etanercept is a biological disease-modifying agent used in the management of rheumatoid arthritis. Its mechanism of action is:: (A) TNF alpha blockade, (B) COX-2 inhibition, (C) IL-6 inhibition, (D) Stabilization of mast cells
Answer is A. Ans. (A) TNF alpha blockade(Ref: KDT 8th/e p943)TNF alpha blocking drugs are used in rheumatoid arthritis and Crohn disease. These include*Adalimumab*Certolizumab*Etanercept*Infliximab*Golimumab