A 35-year-old lady complains of dysphagia, Raynaud's phenomenon and her hands show the following appearance. Investigations show positive ANA. The likely diagnosis is: (A) Systemic lupus erythematosus, (B) Systemic sclerosis, (C) Mixed connective tissue disorder, (D) Rheumatoid ahritis
Answer is B. Systemic sclerosisThe chronic disease is characterized by:1.c/c inflammation, d/t autoimmunity2.Widespread damage to small blood vesselsProgressive interstitial & perivascular fibrosis in skin & multiple organsReference: Harrison&;s principles of Internal Medicine; 19th edition