Glycemic status over the last 2 weeks is best reflected by:: (A) HbA1C, (B) Fructosamine assay, (C) Anhydroglucitol assay, (D) All of the above
Answer is B. The fructosamine assay (measuring glycated albumin) reflects the glycemic status over the prior 2 weeks. Alternative assays of glycemic control (including the 1,5 anhydroglucitol assay) should not be routinely used since studies demonstrating that it accurately predicts the complications of DM are lacking. Ref: Harrison's principle of internal medicine 17th edition, chapter 338.