Mutation in PKHD1 gene causing autosomal recessive polycystic kidney disease (ARPKD) maps to which chromosome?: (A) 16, (B) 4, (C) 6, (D) 12
Answer is C. Mutations of the PKHD1 gene, which maps to chromosome region 6p21-p23. Expressed in adult and fetal kidney, also in liver and pancreas. PKHD1 gene encodes fibrocystin.