True regarding endothelin-l are all except: (A) Bronchodilation, (B) Vasoconstriction, (C) Decreased GFR, (D) Has inotropic effect
Answer is A. Bronchodilatation ET, is primarily a paracrine regulator. It causes vasoconstriction, Bronchoconstriction, cardiac stimulation (ionotropic action), a release of aldosterone and ANP, and a decrease in GFR due to contraction of mesangial cells of the kidney.