Which of the following inclusion body is seen in a patient with Rabies?: (A) Cowdry-B, (B) Negri bodies, (C) Guarneri bodies, (D) Bollinger bodies
Answer is B. Negri bodies are eosinophilic intracellular lesions found within cerebral neurons and are highly specific for Rabies. They are found in about 75% of proven cases of animal rabies. Guarneri bodies are inclusion bodies seen in the cytoplasm of cells infected with small pox virus. Bollinger bodies are found in the cytoplasm of a cell infected with fowl pox virus. In herpes infection giant cells are present, they contain a conglomeration of several nuclei. Each nucleus contain a large inclusion body surrounded by a clear halo. HSV infection is associated with two types of viral inclusions. Cowdry A inclusions are small, round and eosinophilic and are separated from the nuclear material by a halo. Cowdry B inclusions are large, ground glass, eosinophilic, centrally located structures that push nuclear materials to the rim of the nucleus. Ref: Weber D.J., Wohl D.A., Rutala W.A. (2011). Chapter 152. Rabies. In J.E. Tintinalli, J.S. Stapczynski, D.M. Cline, O.J. Ma, R.K. Cydulka, G.D. Meckler (Eds), Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e. Microbiology:Application Based Approach By Pelczar page 427.