Mechanism of action of clomiphene citrate is ?: (A) Binds to estrogen receptors & causes negative feedback at hypothalamus, (B) Binds estrogen receptors & prevents negative feed back at hypothalamus, (C) Binds to progesterone receptors, (D) Progesterone agonist
Answer is B. Ans. is 'b' i.e., Binds estrogen receptors & prevents negative feed back at hypothalamus o Induces gonadotropin secretion (LH, FSH) by blocking estrogenic feedback inhibition on hypothalamus.