All of the following are seen in Goodpasture's syndrome, except:: (A) Crescentic glomerulonephritis, (B) Hemorrhagic inflammation, (C) Anti-GBM antibody, (D) Diffuse alveolar involvement
Answer is D. Goodpasture syndrome Type II hypersensitivity reaction) Presence of antibodies against non-collagenous domain of a3 chain of collagen IV causing destruction of basement membrane in renal glomeruli and pulmonary alveoli. Histologically, the alveoli show focal necrosis (not diffuse involvement), intra-alveolar hemorrhage, presence of hemosiderin laden macrophages and hyperophy of type II Pneumocytes.