"Eye of the Tiger" appearance in MRI is seen in: (A) Wilsons disease, (B) Neuronal accumulation of iron, (C) Alzheimer's, (D) Hallervorden-Spatz syndrome
Answer is D. (D) Hallervorden-Spatz syndrome # Eye of the Tiger Sign refers to abnormal low T2 signal (due to abnormal accumulation of iron) on MRI in the globus pallidus with a longitudinal stripe of high signal (due to gliosis & spongiosis) that can be seen in:> Hallervorden-Spatz syndrome: Classical but not 100% pathognomonic. Progressive supranuclear palsy Early-onset levodopa-responsive parkinsonism Corticobasal ganglionic degeneration