Allergic reactions occur with amino ester local anesthetics due to its metabolite:: (A) P Aminobenzoic acid, (B) Nitrosoamine, (C) Both of the above, (D) None of the above
Answer is A. p-Aminobenzoic acid is one of the metabolites of ester-type compounds that can induce allergic-type reactions in a small percentage of patients. The aminoamides are not metabolized to p-aminobenzoic acid, and repos of allergic reactions to these agents are extremely rare. Ref: Miller's anesthesia-7th ed , Chapter 30.