Antitubercular drug which is least hepatotoxic: September 2010: (A) Rifampicin, (B) Pyrazinamide, (C) Ethambutol, (D) INH
Answer is C. Ans. C: Ethambutol The single biggest problem with TB treatment is drug-induced hepatitis, which has a moality rate of around 5%. Three drugs can induce hepatitis: PZA, INH and RMP (in decreasing order of frequency). It is not possible to distinguish between these three causes based purely on signs and symptoms.