Chaperone proteins play a role in: (A) Protein folding, (B) Protein misfolding, (C) Denaturation, (D) All the above
Answer is A. Chaperone proteins paicipate in the folding of over half of all mammalian proteins. They can "rescue" unfolded proteins that have become thermodynamically trapped in a misfolded dead end by unfolding hydrophobic regions and providing a second chance to fold productively. Ex: Glutathione can reduce inappropriate disulfide bonds that may be formed upon exposure to oxidizing agents such as O2, hydrogen peroxide, or superoxide Reference: Explanation: Harper's Biochemistry; 30th edition; Chapter 5; proteins: higher Orders of Structure