False about PSC: (A) PSC in UC, the association is 30%, (B) Low incidence of cholangitis, (C) Increased incidence of colonic carcinoma in PSC+UC, (D) Despite the presence of diffuse disease, hepatic duct bifurcation is most severely structured segment
Answer is A. Primary sclerosing cholangitis PSC is a cholestatic liver disease characterized by fibrotic strictures involving intrahepatic and extrahepatic biliary tree in the absence of a known precipitating cause More common in HLA B8/DR3 Incidence of UC in PSC ranges from 75-80% PSC is present in 5.5% of patients with chronic UC Ref: Sabiston 20th edition Pgno :1508-1509