The clinical sign of hyaline membrane disease generally first appears –: (A) In the first 6 hours of life, (B) Between 12 and 24 hours of life, (C) Between 36 and 48 hours of life, (D) After 48 hours of lilfe
Answer is A. Clinical features of HMD 

Respiratory distress occurs within the first 6 hours of life.
Clinical features include -


Tachypnea                                                           
o Decreased air entry          a BP may fall

a Retraction                                 
o Fatigue                                                              
o Oliguria                  If untreated

Grunting                                                               

o Pollor 
o Ileus

Cyanosis              
Mixed respiratory & metabolic acidosis