What is the mechanism of action of Delamanid ?: (A) Inhibition of DNA Gyrase, (B) Inhibition of Alanine Racemase, (C) Inhibition of Mycolic acid synthesis, (D) Inhibition of Topoisomerase
Answer is C. DELAMANID: It is an anti-tuberculosis agent derived from the Nitro-dihydro-imidazooxazole class of compounds. MOA: Forms a reactive intermediate metabolite that inhibits Mycolic acid production. USE: In treatment of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in a combination regimen. S/E: QT segment prolongation