MRP2 gene defect results in which of the hereditary disorders of bilirubin metabolism and Transpo is:: (A) Gilbes, (B) Crigler najjar type I, (C) Crigler najjar type II, (D) Dubin johnson-
Answer is D. PARAMETER Syndrome GILBE'S CRIGLER- NAJJAR TYPE I CRIGLER-NAJJAR TYPE II DUBIN-JOHNSON ROTOR'S Incidence 6%-12% Very rare Uncommon Uncommon Rare Gene affected UGT1A1 UGT1A1 UGT1A1 MRP2 Unknown Metabolic defect |Bilirubin conjugation No bilirubin conjugation ||Bilirubin conjugation Impaired canalicular expo of conjugated bilirubin Impaired canalicular expo of conjugated bilirubin Ref:Sleisenger and Fordtran's,E-9,P-326.