Aspirin irreversibly inhibits the following enzyme in the formation of eicosanoids:: (A) Lipoxygenase, (B) Cyclooxygenase, (C) Phospholipase-A2, (D) Peroxidase
Answer is B. Ans. B. CyclooxygenaseCyclooxygenase is required for the synthesis of prostaglandins by arachidonic acid. Aspirin, indomethacin, brufen, phenyl butazone and other NSAIDS inhibits COX (Cyclooxygenase). Aspirin inhibits COX of both PGHS-1 and PGHS-2 by acetylation