All of the following statements about digitalis are true except :: (A) Excretion is mainly renal, (B) Oral absorption is good, (C) Actively metabolized in liver, (D) Lipid soluble
Answer is C. Answer is C (Actively metabolized in Liver) Digoxin is excreted unchanged by the Kidney, mainly by Glomerular filtration. /t is not metabolized by liver. Dose of digoxin need not to be changed in Liver failure. Do not confuse digoxin with digitoxin : The most lipid soluble cardiac glycoside is = Digitoxin e The most rapidly absorbed oral glycoside is = Digitoxin e Digitoxin is primarily metabolized by the liver Q Dose of digitoxin needs to be reduced in liver failure. e