Protein implicated in Familial Amyloidosis is: (A) Serum amyloid A, (B) b2-microglobulin, (C) Amyloid b peptide, (D) Transthyretin
Answer is D. A Classification of AmyloidosisTypeProtein ImplicatedPrimaryPrincipally light chains of immunoglobulinsSecondarySerum amyloid A (SAA)FamilialTransthyretin; also rarely apolipoprotein A-1,cystatin C, fibrinogen, gelsolin, lysozymeAlzheimer's diseaseAmyloid b peptideDialysis-relatedb2-microglobulinRef: Harper&;s Biochemistry; 30th edition; Chapter 52; Plasma Proteins & Immunoglobulins; Table 52-7