Hybridoma cell line is a product of fusion: (A) B cells with mouse myeloma cells, (B) T cells with mouse myeloma cella, (C) B cells with Guinea pig myeloma cells, (D) T cells with guinea pig myeloma cells
Answer is A. The B cells are mixed with mouse myeloma cells and exposed to polyethylene glycol, which causes cell fusion. The product of this fusion is a permanentcell line called a hybridoma capable of providing a continuous supply of monoclonal antibodies.Ref: Harper&;s biochemistry; 30th edition; Chapter 52; 52 Plasma Proteins & Immunoglobulins