Nitroglycerine is effective when administered sublingually because it is:: (A) Non ionized and lipid soluble, (B) Ionized and lipid soluble, (C) Non ionized and Water insoluble, (D) Ionized and water insoluble
Answer is A. Ans. (A) Non ionized and lipid soluble(Ref: KDT 8th/e p28)Nitroglycerin is effective when retained sublingually because it is non-ionized and has very high lipid solubility. Thus, the drug is absorbed very rapidly.