In pemphigus vulgaris, antibodies are present against –: (A) Basement membrane, (B) Intercellular substance, (C) Cell nucleus, (D) Keratin
Answer is B. Pemphigus is an autoimmune disease, with formation of antibodies to pemphigus antigen present in intercellular substance. Pemphigus antigens are desmoglein 3 & 1 in P. vulgaris and desmoglein 1 in P. foliaceous.