MELAS is an inherited condition which occurs due to deficiency of: (A) Complex I, (B) Complex II, (C) Complex III, (D) All the above
Answer is A. MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke) is an inherited condition due to NADH-Q oxidoreductase (Complex I) or cytochrome oxidase (Complex IV) deficiency. It is caused by a mutation in mitochondrial DNA and may be involved in Alzheimer disease and diabetes mellitus. Reference: Harper; 30th edition; Page no: 135