Which of the following reaction is affected in patients of scurvy?: (A) Carboxylation, (B) Acetylation, (C) Hydroxylation, (D) Transamination
Answer is C. Scurvy is due to deficiency of vitamin C. Vitamin C is required for lysyl and prolyl hydroxylases Vitamin C deficiency leads to defective post-translational modification of collagen - loss of tensile strength of blood vessels leading to:- - Bleeding gums -Ecchymoses - Easy bruisability -Poor wound healing (Features of scurvy).