Aspirin prolongs bleeding by inhibiting the synthesis of which of the following?: (A) Adenosine receptors, (B) Cyclic AMP, (C) Prostacyclin, (D) Thromboxane A2
Answer is D. Aspirin inactivates cyclo- oxygenase by irreversible acetylation of the enzyme and thereby inhibit the synthesis of thromboxane A2 even in low doses (75mg/day). From medical pharmacology padmaja 4th edition page no 344