Mechanism of action of dantroline is ?: (A) Inhibits Ca++ secretion from sarcoplasm, (B) Binds to ryanodine receptors to block release of Ca++, (C) Inhibits GABA, (D) Inhibits Gamma motor neuron
Answer is B. Ans. is 'b' i.e., Binds to ryanodine receptors to block release of Ca++ o Dantrolone acts on Ryanodine receptors (RyR) Calcium channels in sarcoplasmic reticulum of skeletal muscles and prevents their depolarization triggered opening --> no release of intracellular Ca-+2 --> No excitation contraction coupling --> No contraction.