Tryptophan deficiency leads to:: (A) Her's disease, (B) Lesch Nyhan syndrome, (C) Hartnup disease, (D) Alkaptonuria
Answer is C. (C) Hartnup disease # Hartnup disease occurs due to impaired intestinal absorption and renal re-absorption of a neutral amino acid, tryptophan.> Tryptophan is required for synthesis of serotonin and nicotinic acid.> Neurological manifestations of Hartnup disease are due to decreased synthesis of serotonin while pellagra-like rash occurs due to decreased synthesis of nicotinic acid.> Her's disease (choice A) is caused by deficiency of liver phosphorylase.