Elongated filaments in Pick's disease consist of: (A) Hyperphosphorylated tau, (B) Ubiquitin, (C) Alpha-synuclein, (D) Beta-synuclein
Answer is A. Harrison's principles of internal medicine 17th edition. *In Pick's disease dementia is frontotemporal dementia *Molecular basis - tau *Causal genes and chromosome - tau exon and intron mutation(17) *Susceptibility - H1 tau haplophytes * Pathology - tau inclusions,pick bodies,neurofibrillary tangles