A 25 year old male presnents with weakness, occasional vomiting hypotension, skin and mucous membrane pigmentgation. The diagnosis can be best established by -: (A) Metyrapone test, (B) Basal plasma Coisol levle, (C) 24-hour urinary 17-Ketosteroid, (D) ACTH stimulation test
Answer is D. after administration of ACTH , coisol level increases. This can be used as an index of the functional reserve of adrenal gland for production of coisol ( Harrison 17 pg 2252)