A 2 year old child presents with scattered lesions in the skull. Biopsy revealed Langerhans giant cells. The most commonly associated is marker with this condition will be: (A) CD 1a, (B) CD 57, (C) CD 3, (D) CD 68
Answer is A. The history is suggestive of langerhans cell histiocytosis( eosinophilic granuloma ).The tumour cells in addition to birbeck granules express HLA -DR, S- 100 and CD1a Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1.page no. 622