All of the following are propeies of local anesthetics EXCEPT:: (A) Blockade of voltage dependent Na+ channels, (B) Preferential binding to resting channels, (C) Slowing of axonal impulse conduction, (D) Increase in the membrane refractory period
Answer is B. - Local anesthetic receptor is located within the channel in its intracellular half. - LA traverses the membrane in unionized form. - LAs act from within the neuron and are more active when the neuron is rapidly firing (i.e., Na+ channels are open). so it doesnot act in resting form.