Acute or rapidly developing tolerance to a drug is?: (A) Anaphylaxis, (B) Teratogenic effects, (C) Induction, (D) Supersensitivity
Answer is B. Tachyphylaxis is the tolerance to a drug that develops rapidly after administration is begun. Anaphylaxis is the full-blown acute hypersensitivity reaction to a drug that is life-threatening due to airway obstruction and cardiovascular collapse. Teratogenic effects of drugs are those adverse drug effects on the fetus which alter its development.Induction is the process by which a drug increases the activity of a metabolic enzyme. Ref: Katzung, pp. 31, 121,854- 85;Blumenthal D.K., Garrison J.C. (2011). Chapter 3. Pharmacodynamics: Molecular Mechanisms of Drug Action. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e