The rationale for sucralfate therapy in peptic ulcers does not include :: (A) It has an acid neutralizing action., (B) It inhibits pepsin mediated protein hydrolysis., (C) It stimulates the production of epidermal growth factor., (D) It stimulates prostaglandin synthesis.
Answer is A. A Sucralfate binds to the base of the ulcer crater and inhibits the pepsin mediated protein hydrolysis. It by itself has no acid neutra-lizing action. Other mechanisms proposed for its effect are stimulation of prostaglandin synthesis and stimulation of local epider-mal growth factor.