Patients with mutations leading to defective beta-oxidation of fatty acid usually have hypoglycemia because of: (A) Less ATP for gluconeogenesis, (B) Less acetyl CoA for glucose formation, (C) Increased fatty acids decrease glucose utilization, (D) Fatty acids inhibit transpo of glucose for metabolism
Answer is B. Acetyl-coenzyme A or acetyl-CoA is an impoant molecule that paicipates in many biochemical reactions in protein, carbohydrate, and lipid metabolism. Its main function is to deliver the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production. Ref-Sathyanarayana 4/e p399