Poor prognosis in AML is indicated by:: (A) Inversion 16, (B) Translocation 15;17 (t15; 17), (C) Normal cytogenecity, (D) Monosomy 7
Answer is D. Monosomy 7 is associated with a very poor prognosis. Patients with t (8, 21), t (15: 17) and inv (16) have a good prognosis.