The drug NOT used in prostatic carcinoma :: (A) Finasteride, (B) Diethyl stilbestrol, (C) Testosterone, (D) Flutamide
Answer is C. Ans. is 'c' Testosterone Medical management of Testicular CaThe aim is to reduce the testosterone level or its effect producing chemical castrationThe drugs areGnRH analogue* (leuprolide acetate*)Initially it produces a rise in LH and FSH which increases testosterone level initially but after sometimes due to down regulation of receptors on pituitary LH & FSH decrease there by decreasing TestosteroneAntiandrogen (Flutamide)*Estrogen (Diethylstilbestrol)*Finasteride*prevents the conversion of testosterone to its active component. It is a 5 alpha reductase inhibitor*Second line t/tKetoconazole*Aminoglutethimide*