40-year-old immunocompromized patient presented with complaints of dysphagia. UGI scopy showed multiple ulcers in the distal esophagus. Biopsy from the esophagus showed the following. What is the diagnosis?: (A) Candida, (B) Cytomegalovirus, (C) Herpes, (D) Eosinophilic esophagitis
Answer is B. Ans. (b) Cytomegalovirus(Ref: Robbins 9th ed p 755)CMV causes shallower ulcerations and characteristic nuclear and cytoplasmic inclusions within capillary endothelium and stromal cells. Infected cells are strikingly enlarged, often to a diameter of 40 m, and show cellular and nuclear pleomorphism. Prominent intranuclear basophilic inclusions spanning half the nuclear diameter are usually set off from the nuclear membrane by a clear halo