Beta-adrenoceptor blocking agent that should be avoided in patients with renal failure is:: (A) Atenolol, (B) Metoprolol, (C) Propranolol, (D) Esmolol
Answer is A. (Ref: Katzung, 14th ed. pg. 179; KDT 6th ed. pg. 140 table 10.2)Lipid insoluble b blockers: These agents are mainly excreted by kidney and are therefore contraindicated in renal failure. These have long duration of action. The drugs are:Nadolol (longest acting b blockers)SotalolAtenololAcebutololBetaxololBisoprololCelioprolol