Which of the following drugs is most likely to cause additive anemia and neutropenia if administered to an AIDS patient taking zidovudine?: (A) Acyclovir, (B) Amantadine, (C) Ganciclovir, (D) Stavudine
Answer is C. * Ganciclovir is the drug of choice for CMV infections. * It should not be combined with zidovudine because both have bone marrow suppressant propey. * It is an analogue of acyclovir which is most active against CMV. but also inhibits other herpes viruses viz. H.simplex, H. zoster and EBV.