All are true regarding superantigens except?: (A) Activate very large numbers of B cells, (B) Bind outside the antibody binding groove, (C) Are medium sized proteins, (D) Cause release of cytokines
Answer is A. Superantigens activate very large number of T cells. NON -MHC restricted They are medium sized proteins which Attach to TCR on lateral side on Vb (Variable) domain, outside the antibody binding groove. They cause release of cytokines that induce >20% of T lymphocytes activation resulting in massive proliferation of T lymphocytes. They have high resistance to proteases.