Dose-limiting toxicity of chemotherapeutic agents is: (A) Bone marrow toxicity, (B) GI toxicity, (C) Neurotoxicity, (D) Respiratory problems
Answer is A. Depression of bone marrow results in granulocytopenia, agranulocytosis, thrombocytopenia, aplastic anemia. This is the most serious toxicity; often limits the dose that can be employed.