Hypogonadotropic hypogonadism with diabetes mellitus is seen in?: (A) Kallman Syndrome, (B) Hypothalamic hamaoma, (C) Granulomatous Hypophysitis, (D) Prader wili Syndrome
Answer is D. Prader wili occurs due to deletion of paternal copies of imprinted SNRPN gene and NECDIN gene on chromosome 15q. It presents with: Hypogonadotropic hypogonadism Diabetes mellitus(adult onset) Hyperphagia Obesity Muscle hypotonia Mental retardation