In juvenile myoclonic epilepsy (JME), which is the most common presentation?: (A) GTCS during sleep, (B) GTCS on awake state, (C) Myoclonus, (D) Absence seizures
Answer is C. Juvenile myoclonic epilepsy (JANZ syndrome) - Polygenetic inheritance, Strong family history - Onset: 10 -19 yrs. - Myoclonic Jerk (early morning) and prominent in morning after awakening. Consciousness is preserved unless severe - EEG: 4-6 Hz Polyspike pattern seen. - May develop GTCS in future and in 30% will also develop absence seizure in future Rx - Valproate (lifelong)