Drugs causing pharmacological adrenalectomy are all except: (A) Ketoconozole, (B) Mitotane, (C) Aminoglutethemide, (D) Methotrexate
Answer is D. Aminoglutethimide, Ketoconazole, Mitotane, Trilostane, Metyrapone inhibits synthesis of steroids Pharmacological adrenelectomy refers to mimicking a situation of adrenelectomy where the complete synthesis of coicosteroids is stopped by using drugs line glucocoicoid synthesis inhibitors. Ref: Katzung 11th ed pg 695.