All of the following are true about Clozapine EXCEPT: (A) It can cause agranulocytosis, (B) It has more affinity to D4 receptors compared to Dr, (C) Has a lesser potency in blocking 5-HT2 than the D2 receptor, (D) An atypical antipsychotic agent
Answer is C. (C) Has a lesser potency in blocking 5-HT2 than the D2 receptor # Model "atypical" antipsychotic agent is clozapine, a dibenzodiazepine that has a greater potency in blocking the 5HT2 than the D2 receptor and a much higher affinity for the D4 than the D2 receptor. Its principal disadvantage is a risk of blood dyscrasias.> Clozapine side effects: Agranulocytosis (1%); weight gain; seizures; drooling; hyperthermia