Genetic deficiency of complement factor causes:: (A) Hereditary angioneurotic edema, (B) SLE- an autoimmune disease, (C) Pyogenic bacterial infections, (D) All of the above
Answer is D. Ans: d (All of the above) Ref: Ananthanaraya 7th ed, p. 115Deficiency of complement components are associated with a variety of syndromesDeficiencySyndromeCl inhibitorHereditary angoneurotic edema (main mediator of edema is C2 kinin released)C1C2C4SLE & collagen vascular disordersC3 & C3b inactivatorRecurrent pyogenic infectionsC5-8Gram - ve bacteremiaC9No particular diseaseRemember: Treatment of hereditary angioneurotic oedema is infusion of FFP