The antiepilectic drug which does not produce enzyme induction is: (A) Phenobarbitone, (B) Sodium valproate, (C) Phenytoin sodium, (D) Carbamazepine
Answer is B. The four major enzyme-inducing AEDs (carbamazepine, phenytoin, phenobarbital and primidone) stimulate the metabolism and reduce the serum concentration of most other concurrently administered AEDs, most notably valproic acid , tiagabine , ethosuximide , lamotrigine , topiramate , REF : KD TRIPATHI 8TH ED.