The hepatotoxic octapeptides of Amanita phalloides usually produce:: (A) Massive hepatic necrosis, (B) Centrilobular zonal necrosis, (C) Peripoal injury, (D) Granuloma formation in liver
Answer is A. The hepatotoxic octapeptides of Amanita phalloides usually produce massive hepatic necrosis; the lethal dose of the toxin is 10 mg, the amount found in a single death cap mushroom. Ref: Harrison's Principles of Internal Medicine, 18th Edition, Page 2558.