A patient has been diagnosed with Marfan syndrome. Which of the following is the most common cause of death in these patients?: (A) Liver disease, (B) Myocardial infarction, (C) Recurrent infection, (D) Aoic disease
Answer is D. Marfan syndrome Autosomal dominant Defect in an extracellular glycoprotein called fibrillin-1. Loss of fibrillin- Clinical manifestations of Marfan syndrome. Loss of structural suppo in microfibril rich connective tissue and excessive activation of TGF-b signaling. Skeletal abnormalities Unusually tall Exceptionally long extremities and long, Tapering fingers and toes. Cardiovascular lesions Mitral valve prolapse Aoic Dissection.