Which of the following drug is contraindicated in variant angina?: (A) Diltiazem, (B) Nitrates, (C) Propranolol, (D) Verapamil
Answer is C. Variant angina is caused by coronary vasospasm DOC:Sublingual Nitroglycerine Prophylaxis : Calcium channel blockers (like verapamil and Diltiazem) and nitrates Beta blockers are avoided as they may precipitate coronary vasospasm by counteracting beta 2 mediated coronary vasodilation. Therefore they are avoided in variant angina.