True statement about p53 are all except: (A) It regulates ceain genes involved in cell cycle, (B) Its increased levels can induce apoptosis, (C) Its activity in cells decrease following UV radiation & stimulates cell cycle, (D) Mutations in p53 are the MC genetic alterations seen in human cancer
Answer is C. TP53 Transcription factor; Has propeies of both an oncogene and a tumour suppressor gene Small arm of Chr 17 (17p13.1) Protein product: p53 "Guardian of the genome"; "molecular policeman"; critical gatekeeper Li Fraumeni syndrome - Hereditary loss an allele Ca lung, colon, breast LOF mutation of TP53 - MC mutation in >50% cancers