True statement regarding development of drug resistance in MRSA is:: (A) Results due to penicillinase enzyme production, (B) Occurs due to change in penicillin-binding proteins, (C) Chromosome mediated, (D) Treated with amoxicillin + clavulanic acid
Answer is B. Ans. (B) Occurs due to change in penicillin-binding proteins(Ref: Katzung's 11/e p776, KDT 8/e p743)Methicillin resistance occurs due to altered PBPs, thus no penicillin, (infact no beta-lactam antibiotic) is useful against methicillin-resistant Staphylococcus aureus (MRSA) infections.