Acid Labile penicillin is-: (A) Cloxacillin, (B) Flucloxacillin, (C) Methicillin, (D) Phenoxy Methyl penicillin
Answer is C. Ans. is 'c' i.e., Methicillin o Gastric acid destroyes the penicillins and decreases their bioavailibility. o All penicillins are acid labile accept phenoxymethyl penicillin (penicillin V), Cloxacillin, Flucloxacillin, Oxacillin, Dicloxacillin, ampicillin. Note - Cloxacillin, flucloxacillin, oxacillin, and dicloxacillin are resistant to both acid as well as penicillinase.