About Langerhans cell histiocytosis, true are all EXCEPT: (A) Peak incidence less than 3 years of age, (B) Radiosensitive, (C) Diffuse form is known as Letterer -siwe-disease, (D) Gonadal involvement occurs
Answer is D. DISCUSSING THE OPTIONS ONE BY ONE: a. Peak incidence less than 3 years of age - True; More common and more severe in younger children b. Radiosensitive -True - as Bone lesions & Pituitary lesions causing DI, respond well to radiotherapy c. Diffuse form is known as Letterer-siwe disease -True d. Gonadal involvement occurs - False; Gonadal involvement is usually not seen in LCH. - Involvement of bones, scalp, pituitary, lungs, hematopoiesis is seen