A 70 yrs male patient has single well defined lytic lesion of skull. The patient had no other complaint and urine examination had no abnormality. What is the most likely diagnosis?: (A) L.C.H, (B) Localized myeloproliferative disorder, (C) Generalized myeloproliferative disorder, (D) Tumor of osteoblasts
Answer is A. Langerhans's cell histiocytosis X-ray- well-demarcated lytic lesion, "hole within a hole". M/E - "Tennis-racket" inclusion bodies and Birbeck granules Plasmacytoma Localized myeloproliferative disorder, does not present with lytic lesions in the skull. Generalized myeloproliferative disorder is multiple myeloma which presents with characteristic "punched-out" lytic lesions in the skull. Serum or urinary electrophoresis measures immunoglobulins over-produced by the plasma cells. Lytic lesions of skull: M- Metastasis E- EG(eosinophilic granuloma) L- LCH/Lymphoma T-T.B H-Hyperparathyroidism O- Osteomyelitis R- (Radiotherapy) M- MM(Multiple myeloma) E- Epidermoid