The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDs because they:: (A) Cause sodium excretion, (B) Increase the clearance of antihypertensive drugs, (C) Decrease the absorption of antihypertensive drugs, (D) Decrease the synthesis of vascular prostacyclin
Answer is D. Ans. (D) Decrease the synthesis of vascular prostacyclins(Ref: KDT 8th/e p215)*PGE2 and PGI2 cause renal vasodilation, natriuresis and increased water clearance due to inhibition of the action of ADH.*Loop diuretics act partly by increasing the stimulation of COX; therefore NSAIDs attenuate the diuretic action of these drugs.