For which one of the following tumors Gastrin is a biochemical marker?: (A) Medullary carcinoma of thyroid, (B) Pancreatic neuroendocrine tumor, (C) Pheochromocytoma, (D) Gastrointestinal stromal tumor
Answer is B. Gastrin is secreted by Gastrinomas, which are neuroendocrine tumors most commonly found in duodenum. Gastrinoma:- Type of pancreatic Neuro endocrine tumor(PNET) Patient with MEN I syndrome have more chance of developing gastrinoma. -Other neuroendocrine tumor is carcinoid tumor. -Marker of medullary carcinoma of thyroid is calcitonin and GIST is CD117 (c-kit) -GIST- Mesenchymal tumor.