Which of the following statement is not true about domperidone?: (A) It rarely causes extrapyramidal side effects, (B) It is a D2 receptor antagonist, (C) Its antiemetic efficacy is higher than metoclopramide, (D) It causes loose stool
Answer is C. Domperidone is an antiemetic which is classed under prokinetic drugs. It is a D2 antagonist; But it crosses blood brain barrier poorly - hence extrapyramidal side effects are rare, hyperprolactinemia can occur. Its antiemetic efficacy is LOWER than metoclopramide. Side effects are much less than with metoclopramide; dry mouth, loose stools, headache, rashes, galactorrhea, cardiac arrhythmias on rapid IV injection.Ref:KD Tripathi 8th ed.