MOA of Teduglutide in sho bowel syndrome?: (A) GLP-2 inhibitor, (B) HT1a inhibitor, (C) GLP-1 analogs, (D) C-peptide analogs
Answer is A. Ans. A. GLP-2 inhibitorGlucagon-like peptide-2 (GLP-2) - Impoant intestinotrophic growth factor & mediator of intestinal adaptation.FDA approved teduglutide (Gattex--NPS) to treat sho bowel syndrome in adult patients requiring additional nutrition from I.V. parenteral nutrition.Effectively improves fluid absorption.