Which of the following hematological condition is depicted below?: (A) Multiple myeloma, (B) Megaloblastic anemia, (C) Chronic myeloid leukemia, (D) Metastasis
Answer is A. Ref. Robbins Pathology. 9th edition. Page. 620
 
The picture shows many atpical plasma cells – Diagnostic of Myeloma

Malignant proliferation of plasma cells characterised by monoclonal gammaglobulinaemia (paraproteinaemia)
Cell of origin – Post germinal centre B cells
Stages
	
MGUS
Smoldering myeloma
Myeloma


MGUS – most common plasma cell dyscrasia
Myeloma – CRAB Features
	
Hypercalcemia
Renal Insufficiency
Anemia
Bone lytic lesions