Li-Fraumeni syndrome has the risk of development of:: (A) Squamous cell carcinoma, (B) Basal cell carcinoma, (C) Osteosarcoma, (D) Both 1 & 3
Answer is D. Li-Fraumeni syndrome (germline TP53 mutation) is a predisposing factor for osteosarcoma development.
Reference: Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 227