The primary mechanism of action of local anesthetics is: (A) Blockade of voltage-gated sodium channels, (B) Stimulation of voltage-gated N-type calcium channels, (C) Activation of ligand-gated potassium channels, (D) Blockade the GABA-gated chloride channels
Answer is A. The primary mechanism of action of local anaesthetics is the blockade of voltage-gated sodium channels <img class="fr-fic fr-dib" style="width: 300px;" src=" /> Ref: Katzung 13e pg:443