Zidovudine toxicity is increased by all except -: (A) Azithromycin, (B) Probenecid, (C) Cisplatin, (D) Paracetamol
Answer is A. Paracetamol increases zidovudine toxicity ,probably by competing for glucuronidation. Azole antifungals also inhibit AZT metabolism. Other nephrotoxic & myelosuppressive drugs & probenecid enhance toxicity . Reference :Tripathi textbook of pharmacology 7th edition pg no 807.