A child present with recurrent episodes of sinopulmonary infection by bacteria with polysacharide rich capsule. Deficiency of which of the following immunoglobulin subclasses should be specifically investigated -: (A) IgA, (B) IgG1, (C) IgG2, (D) IgA + IgG2
Answer is D. Ans. is 'd' i.e., IgA+IgG2 Primary Immunodeficiency Diseases, Defination, Diagnosis and Management . IgG2 dificiency is the most common subclass disorder associated with recurrent infections by polysaccharide-encapsulated bacteria. Such infections are more frequent in patients with associated IgA deficiency.