What enzyme is inhibited by etoposide ?: (A) Topoisomerase I, (B) Topoismerase II, (C) Dihydrofolate reductase, (D) Dihydro orotate oxidase
Answer is B. Ans. is 'b' i.e., Topoisomerase(Ref: KDT 7h/e p. 8661)EtoposideSemisynthetic derivative of podophyllotoxin, a plant glycoside'Not a mitotic inhibitor, but arrests cells in the G2 phase and causes DNA breaks by affecting DNA topoisomerase-2 function.