Hyperacute rejection is due to: (A) Preformed antibodies, (B) Cytotoxic T lymphocyte mediated injury, (C) Endothelitis caused by donor antibodies, (D) Circulating macrophage mediated injury
Answer is A. Hyperacute rejection occurs when preformed anti-donor antibodies are present in the circulation of the recipient. Such antibodies may be present in a recipient who has previously rejected kidney transplant, Multiparous women, Prior blood transfusionsHyperacute Rejection occurs within minutes or hours after transplantation.Robbins pathology 9e Pg: 233