Not present in Sideroblastic anaemia is ?: (A) Microcytic anaemia, (B) Decreased transferrin saturation, (C) Sideroblast cells in blood smear film, (D) Ineffective erythropoesis
Answer is B. Ans. is 'b' i.e., Decreased transferrin saturation Sideroblastic anemia Sideroblastic anemia is a type of anemia in which the body has adequate amount of iron but is unable to corporate it into hemoglobin. Pathogensis o The basis defect is a failure to completely form heme molecules, whose biosynthesis takes place paly in the mitochondria. o The iron enters into the mitochondria, but cannot be utilized to synthesize heme. So iron, accumulates in mitochrondria giving a ringed appearance --> Ringed sideroblast. o Because these ringed sideroblastis can develop poorly or not at all into mature RBCs, anemia is a consequence.