The basis of combining Ritonavir with Lopinavir: (A) Pharmaceutical compatability, (B) CYP3A4 inhibiton NY Ritonavir, (C) Long elimination half life of Ritonavir, (D) Ability to counteract side effects of Lopinavir
Answer is B. Refer Katzung 10/e p810 Ritonavir is a microsomal enzyme inhibitor paicularly of CYP3A4 .it decreases the metabolism of other drugs and thus lower dose of Lopinavir can be used in treatment of HIV when combined with Ritonavir