Which of the following effects is unlikely to occur during treatment with imipramine?: (A) Elevation of seizure threshold, (B) Mydriasis, (C) Sedation, (D) Urinary retention
Answer is A. (Ref: KDT 6/e p444) Imipramine is a tricyclic antidepressant. It inhibits the reuptake of serotonin and nor-adrenaline. In addition, it possesses anticholinergic and a-blocking propeies are: Increased risk of seizures due to lowering of Seizure threshold is an adverse effect of this drug.