Anti-inflammatory dose of aspirin ?: (A) 500 mg/d, (B) 1 - 2 g/d, (C) 3 - 6 g/d, (D) 6 - 12 g/d
Answer is C. Ans. is 'c' i.e., 3 - 6 g/d The anti-inflammatory action of aspirin is exeed at high doses of 3 - 6 g/ day or 100 mg/ Kg/ day. The anti-inflammatory action is mainly due to inhibition of COX, causing inhibition of PGs synthesis. In addition to COX inhibition, quenching of free radicals may contribute to its anti-inflammatory action.