Which of the following tumors show increased -kit -: (A) Yolk sac tumor, (B) Embryonal carcinoma, (C) Choriocarcinoma, (D) Seminoma
Answer is D. Ans. is 'd' i.e., Seminoma o C KIT or CDII 7 is a proto-oncogene, overexpression or mutations of this protein can lead to cancer. o Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.