Sensitivity of central chemorecepter in COPD -: (A) Decreased to H+, (B) Increased to H+, (C) Increased to PCO2, (D) Increased to PO2
Answer is A. Ans. is 'a' i.e., Decreased to H+ o Primary stimulus for central chemoreceptors is an increase in hydrogen ion concentration (H) in CSF. o But, central chemoreceptors are depressed in hypoxia (COPD causes hypoxic hypoxia). "Central chemoreceptors are not stimulated by hypoxia; rather like any other cells, they are depressed by- hypoxia " ___ Priciples of medical physiology o Thus, COPD will cause depression of central chemoreceptors to other stimuli as it causes hypoxic hypoxia.