Drug distribution is inversely propoional to: (A) Plasma protein binding, (B) Lipid Solubility, (C) fat layer in the body, (D) structure of drug
Answer is A. The extent of distribution of a drug depends on its lipid solubility, ionization at physiological pH, the extent of binding to plasma and tissue proteins, differences in regional blood flow. If PPB is high VD is low, PPB is inversly propoional to vd drugs with low vd usually have high ppb ref; KD Tripathi pharmacology 6th edition (page no;18)