Drug of choice for pneumocystis carinii is: (A) Doxycycline, (B) Cotrimoxazole, (C) Tetracycline, (D) Dapsone
Answer is B. The treatment of choice for PCP is trimethoprim-sulfamethoxazole (TMP-SMX), given either IV or PO for 14-21 days .TMP-SMX, which interferes with the organism's folate metabolism, is at least as effective as alternative agents and is better tolerated. Ref Harrison 19th edition pg 1019 Davidson edition23rd pg 587