Mechanism of action of Temozolomide is :: (A) Alkylation of DNA, (B) Inhibition of topoisomerase, (C) Microtubule inhibition, (D) Proteasome inhibition
Answer is A. Temozolomide is an alkylating agent . It is the drug of choice for brain tumors.Other alkylating agents are:* If: Ifosfamide* Bus: Busulfan* Not: Nitrosoureas* Present: Procarbazine* Take: Temozolamide* My: Mephalan, Mechlorethamaide* Cycle: CyclophosphamideTopoisomerase inhibitor is Etoposide.Microtubule inhibitors are Vincristin, Vinblastin.Proteosome inhibitors are Boezomib.