Neurofibrillary tangles and agarophilic plaque are character-istic feature of: (A) Alzheimers d/s, (B) CJD, (C) Hepatic encephalopathy, (D) Parkinsonism
Answer is A. Ans a: Ref: Harrison 17th ed pg 2541The area affected in Alzheimer's d/s are hippocampus temporal cortex and nucleus basalis of mayemet Microscopic finding are neurofibrillary tangles and senile neuritic plaques Neuritic plaque contain a central core that contain A? amyloid) proteoglycans, apoE4, alpha 1 antichymotrypsin &other proteinsAccumulation of A-beta amyloid on cerebral arterioles is amyloid angi-opathy.NFT- are silver staining, twisted neurofilaments in neuronal cytoplasm which represent abnormally phosphorylated tau protein