What is the effect of progesterone on lipids?: (A) Lowers LDL, increases HDL, (B) Lowers HDL and increases LDL, (C) Lowers HDL and lowers LDL, (D) Increases LDL and lowers HDL
Answer is C. Progesterone tend to lower HDL level. The mechanism appears to involve an increase in (Hepatic lipase)HL activity. It also decreases triglycerides and modestly lowers LDL levels due to decreased production of VLDL apoB. Ref: Principles and Practice of Endocrinology and Metabolism, 3e.