True statement about cyclooxygenase-2 is: (A) It Is not inhibited by indomethacin, (B) It I'd inducible, (C) It generate cytoprotective prostaglandins in gastric mucosa, (D) It is found only in fatal tissues
Answer is B. Ref-KDT 6/e p185 COX-1 is a house-keeping enzvme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a non-selective inhibitor of both isoforms of COX.