Use of valproate during pregnancy may result in:: (A) Mental retardation, (B) Respiratory depression, (C) Hydantoin syndrome, (D) Neural tube defect
Answer is D. Valproate crosses the placenta and has been reported to have caused teratogenic effects, including neural tube defects (anencephaly, meningomyelocele, and spina bifida) in the fetus when the mother received valproate during the first trimester of pregnancy.