For which of the following seizures would carbamazepine, phenytoin, and primidone be prescribed as the appropriate drug treatment for prevention?: (A) Complex paial, (B) Simple paial, (C) status epilepticus, (D) Generalized tonic clonic
Answer is D. Generalized tonic-clonic seizures are convulsive and can be the result of paial seizures. Carbamazepine, phenytoin, and primidone are among the drugs recommended for generalized seizures. Primidone is a prototype deoxy barbiturate. Phenytoin is a hydantoin and these drugs are highly fat soluble. They stabilize membranes by decreasing Na+ conductance during the period of high-frequency firing. Ref: Greenberg D.A., Aminoff M.J., Simon R.P. (2012). Chapter 12. Seizures & Syncope. In D.A. Greenberg, M.J. Aminoff, R.P. Simon (Eds), Clinical Neurology, 8e.