A patient of prinzmetal's angina is started on isosorbide mononitrate. What is the mechanism of action of nitrates in this condition?: (A) Reduced cardiac contractility, (B) Increased left ventricular end diastolic volume, (C) Decreased diastolic perfusion pressure, (D) Endothelium independent coronary vasodilation
Answer is D. Ans. (D) Endothelium independent coronary vasodilation(Ref: KDT 7th/e p541)Predominant mechanism of action of nitrates in angina:*In Classical angina: Decrease in preload*In Variant angina: Coronary vasodilation