Preformed antibodies cause: (A) Hyperacute rejection, (B) Acute rejection, (C) Chronic rejection, (D) Acute humoral rejection
Answer is A. Rejection- Antibody mediated Humoral or hyperacute rejection When preformed antidonor antibodies are present in circulation of recipient Previous rejection of a transplant Multiparous women Prior blood transfusions Mechanisms of injury - complement dependent cytotoxicity, inflammation, ADCC. Target is graft vasculature - rejection vasculitis