An antidepressant drug which is known to have both high sedative and anticholinergic activity is:: (A) Phenelzine, (B) Amitriptyline, (C) Fluoxetine, (D) Trazodone
Answer is B. (Ref: KDT 6/e p443, 444) Tricyclic antidepressants (TCA) possess anticholinergic and sedative propeies. Amitriptyline and tripitramine possess highest sedative and antimuscarinic actions.