Local anaesthetics acts by inhibiting: March 2012: (A) Sodium channels, (B) Potassium channels, (C) Calcium channels, (D) Magnesium channels
Answer is A. Ans: A i.e. Sodium channels Local anaesthetics act by inhibiting sodium channels from inside Local anesthetics Generally blocks: Sodium channels Potency of LA depends on: Lipid solubility Susceptibility of fibres to LA: Type B > type C > type A Amide linked LA: - Lidocaine, - Bupivacaine etc. Ester linked LA: - Cocaine,