True statement about clonidine are all except-: (A) Increases parasympathetic outflow, (B) Decreases sympathetic outflow by blocking central alpha receptor, (C) Used in Hypertension, (D) Prazosin is used to antagonize side effects of clonidine
Answer is D. Ans-D Clonidine is an alpha-2 agonist that acts by decreasing the central sympathetic outflow.Sedation, dry mouth and rebound hypertension are the principal adverse effects associated with clonidine. Prazosin is an a1 selective blocker, therefore it is not able to block alpha-2 mediated actions.