Increased uric acid level in plasma is due to: (A) Increased purine utilization, (B) Decreased purine synthesis, (C) Decreased degradation purine, (D) Decreased reutilization purine
Answer is D. Salvage pathway ensures the recycling of purines formed by the degradation of nucleotides.Some reactions will consume PRPP and produce more nucleotides will inhibit the enzymes thus salvage pathway is blocked.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 567