Which of the following regarding sickle cell disease is false?: (A) Single nucleotide change results in change of Glutamine to Valine, (B) Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue, (C) HbS provides resistance against malaria, (D) Binding of deoxyHbA terminates fiber polymerization
Answer is B. In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic “sticky patch” on the surface of the β subunit of both oxyHbS and deoxyHbS.
Ref: Harper’s illustrated biochemistry. 30th edition page no: 56