All-trans-retinoic acid is used in treatment of:: (A) Acute promyelocytic leukemia, (B) A.L.L., (C) CML, (D) Transient myeloproliferative disorder
Answer is A. Arsenic trioxide (Trisenox) and all-trans retinoic acid (ATRA) are anti-cancer drugs that can be used alone or in combination with chemotherapy for remission induction of a ceain subtype of AML called promyelocytic leukemia. These drugs cause leukemia cells with a specific gene mutation to mature and die, or to stop dividing. REFERENCE: www.mayoclinic.org