Ideal substance for measuring GFR should have all characteristics except: (A) Should be secreted in tubules, (B) Should be non-toxic, (C) Should not remain in the body, (D) Should not be protein bound
Answer is A. The Ideal substance to measure GFR is Inulin or following reasons ; It is non-toxic; It is freely filterable by the glomeruli; it is not bound to proteins It is neither secreted nor reabsorbed by the tubules; It is not synthesized, stored, or destroyed by the kidney . Thus, Filtered inulin = excreted inulin .Hence, it will give an exact estimate of the GFR. Endogenous creatinine clearance is used most commonly used to estimate the GFR.