Which of the following is not an insulin analogue?: (A) Insulin glargine, (B) Insulin lispro, (C) Actrapid, (D) Insulin aspart
Answer is C. Ans. (C) Actrapid(Ref: KDT 8/e p285)Actrapid (regular insulin) and monotard (Lente-insulin) are unmodified insulins with same amino acid squence as natural insulinLispro, aspart, glulisine and glargine are insulin analogues in which slightly different amino acid sequence is present to modify pharmacokinetics.