Which of the following adverse effects is most likely to occur with sulfonamides?: (A) Neurologic effects including headache, dizziness, and lethaargy, (B) Hematuria, (C) Fanconi's anemia, (D) Skin reactions
Answer is D. (Ref: KDT 6/e p684) Rash is the most common adverse effect seen with the use of sulfonamides.