All of the following statements about vincristine are true except: (A) It acts by inhibiting mitosis, (B) It prominent adverse effects is peripheral neuropathy, (C) It does not suppression bone marrow, (D) It is a drug of choice for solid tumors
Answer is D. Vincristine is a vinca allkaloid. It acts in M-phase of cell cycle by inhibiting the formation of spindle. It is a marrow sparing drug and causes peripheral neuropathy as a prominent adverse effect. It is used for the treatment of hematological malignancies like Hodgkin's lymphoma and leukemias.It is ineffective against solid tumors. Ref-KDT 6/e p824,825