The test result of which investigation done, for a child with developmental delay is shown below?: (A) Multiplex Ligation-dependent probe Amplification, (B) DNA microarray, (C) Fluorescent in situ hybridisation, (D) Chromosomal painting
Answer is B. DNA microarray is used to identify thousands of different gene expressions at the same time- Recommended for unexplained intellectual disability. Fluorescent in situ hybridisation/Chromosomal painting- uses fluorescent probes for specific chromosome Multiplex Ligation-dependent probe Amplification- uses specific markers for specific region of chromosome