True statement regarding first order kinetics is:: (A) Rate of elimination is independent of plasma concentration, (B) A constant proportion of plasma concentration is eliminated per unit time, (C) Half life increases with dose, (D) Clearance decreases with dose
Answer is B. Ans. (B) A constant proportion of plasma concentration is eliminated per unit time(Ref: RID 8th/e p38-39)In first order kinetics, rate of elimination is proportional to plasma concentration of the drug. Half life and clearance are constant in first order kinetics.