Methotrexate toxicity is treated by?: (A) Folinic acid, (B) Folic acid, (C) Vitamin B 12, (D) Folinic acid+Vitamin B 12
Answer is A. Ans. is 'a' i.e., Folinic acid Folinic acid rescue o Where it is desired to maximise the effect of methotrexate a potentially fatal dose is given and is followed 24 h later by a dose of folinic acid to terminate its action. o High concentrations of methotrexate are obtained and bone marrow cells recover better than the tumor cells and some degree of useful selectivity is achieved