Concomitant use of valproic acid and lamotrigine increases the risk of :: (A) Chondrodysplasia punctata, (B) Paroxysmal Nocturnal hemoglobinuria, (C) Stevens-Johnson syndrome, (D) Floppy infant syndrome
Answer is C. Stevens-Johnson syndrome Concomitant use of valproic acid and lamotrigine increases the plasma level of lamotrigine and increases the risk of Stevens-Johnson syndrome; hence, lamotrigine should be staed as a low dose with gradual escalation.