Which of the following is the best technique to screen neonates for inherited metabolic disorders: (A) Tandem mass spectrometry, (B) Northern Blotting, (C) PCR, (D) ChIP technique
Answer is A. Tandem mass spectrometry is a technique in which compounds are separated by molecular weight by one mass spectrometer, fragmented as they exit, and identified on the basis of their fragments by a second mass spectrometer.