Which of the following anticancer drugs can cause hypercoagulable state?: (A) 5-FU, (B) L-asparaginase, (C) Melphalan, (D) Carmustine
Answer is B. Ref: Katzung 11/e p955 L-asparaginase cause the breakdown of asparagine and thus interference with protein synthesis. It can inhibit the production of clotting factors (responsible for cerebal hemorrhage) as well as anti-clotting protiens(can lead to coical viens thrombosis and other hypercoagulable state).