E-cadherin is more often mutated in: (A) Diffuse type of gastric cancer, (B) Intestinal type of gastric cancer, (C) Malignant ulcer of stomach, (D) Erosive gastritis
Answer is A. Hereditary diffuse gastric cancer is an inherited form of gastric cancer. Patients with this disorder, resulting from a gene mutation for the cell adhesion molecule E-cadherin, have an 80% lifetime incidence of developing gastric cancer.Ref: Sabiston 20th edition Pg: 1215