All of the following are good prognostic factors for childhood Acute Lymphoblastic Leukemia, except:: (A) Hyperdiploidy, (B) Female sex, (C) Pre B cell ALL, (D) t (12 : 21) translocation
Answer is D. Hyperdiploidy, Female sex and pre B cell ALL are associated with good prognosis. t (12 : 21) translocation may be associated with a poor prognosis and is the single answer of exclusion. Ref: Pediatric Oncology: A Comprehensive Guide By Paul Imbach, Thomas R. Kuhne, Robe Arceci, 2004, page 23.