8 year old boy is brought with c/o progressive weakness & difficulty getting up the shows the following finding what is the MC type of mutation leading to this condition?: (A) Inversion, (B) Transrversion, (C) Frame shift mutation, (D) Splicing mutation
Answer is C. Frame shift mutation Inseion or deletion of genes can alter the reading frame of the DNA Eg: Muscular dystrophy Mutation of DMD gene at Xp21 encodes dystrophin- sarcolemal Protein C/f : progressive weakness difficulty in getting up