The following are true about enfuviide except:: (A) Administered by s.c route, (B) Effective on HIV 1 and HIV 2 strains, (C) Binds to HIV gp41, (D) No cross resistance with other anti-retroviral drugs
Answer is B. Enfuviide It is an Entry (fusion) inhibitor. MOA: By binding to HIV-1 gp41 Active on HIV 1& not active against HIV-2. Cross resistance not seen with other classes of ARV drugs. Given s.c. twice daily. Used as add on drug for failed regimens. Adverse effects: Pain at injection site and it cause local nodules or cysts.