Mechanism of action of cholera toxin is through:: (A) Gangliosides, (B) Adenyl cyclase, (C) Gangliosides + adenyl cyclase, (D) Exotoxin
Answer is C. Cholera enterotoxin Light toxin: binds with ganglioside in epithelial cell membrane Heavy toxin: activates adenyl cyclase in epithelial cell wall which increase cAMP, leading to outpouring of isotonic fluid in lumen of intestine