A hypeensive patient Sattu already receiving a drug 'X' to control his BP was prescribed a tricyclic antidepressant. This resulted in the abolition of the antihypeensive action of 'X'. Which of the following drug can be 'X'?: (A) Enalapril, (B) Clonidine, (C) Atenolol, (D) Diltiazem
Answer is B. (Ref: KDT 6/e p444) TCAs abolish the antihypeensive effect of guanethidine and Clonidine by inhibiting their transpo into the adrenergic neurons.