Dicumarol is a drug that impairs the utilization of vitamin K by the liver. Dicumarol therapy, therefore, would decrease the plasma concentration of which of the following procoagulants: (A) Prothrombin, (B) Fibrinogen, (C) Antihemopilic factor (factor VIII), (D) Ac - globulin (factor V)
Answer is A. Ans. (a) ProthrombinRef: Ganong, 25th ed/p.567Factor II is also called Prothrombin. It is a vitamin K dependent factorWarfarin - acts by inhibiting Vitamin K Epoxide reductase (VKORC1)