A child is brought by mother with HO massive hemetemesis with HO drug intake previously with NSAIDS and on Rx. Associated with moderate splenomegaly diagnosis is: (A) Oesophageal varices, (B) Duodenal ulcer, (C) Drug induced gastritis, (D) Peptic ulcer
Answer is A. Causes of portal hypertension

Pre sinusoidal
Extrahepatic (most commoon) :portal vein/splenic vein thrombosis,splenic AV fistula,massive splenomegaly.
Intrahepatic: sarcoidosis, schistosomiasis, congenital hepatic fibrosis, myeloproliferative disorders, nodular degenerative hyperplasia, idiopathic portal fibrosis.
Sinusoidal
Cirrhosis due to any cause.
Post sinusoidal
Budd chiari syndrome,right heart failure,constrictive pericarditis,web in inferior venacava.