First antibody to appear in hepatitis -: (A) IgM anti-Hbe, (B) IgG-anti-Hbe, (C) IgM-anti-HBc, (D) IgM anti-HBs
Answer is C. Anti-HBV appears in serum a week or two after the appearance of HBsAg. It is therfore the earliest antibody marker to be seen in blood? long before anti-HBe or anti-HBs. REF:ANANTHANARAYAN AND PANIKER'S TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO-546