Organophosphates act by inhibiting the enzyme acetylcholinesterase. Which type of enzyme inhibitors are they: (A) Competitive and reversible, (B) Non competitive and Irreversible, (C) Uncompetitive and reversible, (D) Competitive and Irreversible
Answer is D. Both organophosphates and carbamates cause competitive inhibition of acetylcholineesterase by binding to esteratic site. However organophosphates are irreversible and most carbamates(except carbaryl and propoxur) are reversible inhibitors.thus, the type of inhibition of acetylcholine esterase caused by organophosphates is competitive and Irreversible. Ref-Goodman and Gillman 12th/e p242