Patient has been given pencilling 48hrs ago, with no history of drug allergy. Now he develops wheeze hemolysis.antibody for pencilline is positive .type of hypersensitivity is which of the following: (A) Type 1, (B) Type2, (C) Type3, (D) Type4
Answer is B. Ref Robbins 9/e p205 Administration of pencilline causing no symptoms in 48 hours with no previous history of allergy rules out type 1 hypersensitivity The patient presented with haemolysis which can be because of antibody formation against red cells the formation of autoantibody is a feature associated with type 2 hypersensitivity Thus clinically Transfusion reaction in which cells from an incompetent donar ract with and are opsonized by performed antibody in the host Hemolytic disease of the newborn : antigen difference between mother and foetus Autoimmune hemolytic anaemia ,agranulocytosis .and thrombocytopenia ,in which individual produce antibodies to their own blood cells ,which are then destroyed