True about first order kinetics of elimination -: (A) Constant amount of drug is eliminated, (B) Rate of elimination is not related to plasma concentration, (C) Clearance remains constant, (D) Half life decreases with decreased concentration
Answer is C. Ans. C. Clearance remains constantFirst order kinetics:Rate of elimination is directly propoional to Plasma Concentration.Clearance remains constant -Due to increasing plasma concentration, increases the rate of elimination propoionately.(CL = rate of elimination / Plasma Conc).Half life remains constant -Due to time required to reduce plasma concentration to half is same (rate of eliminationchange propoionately with plasma concentration).