The effect of thiopentone on the CNS is quickly terminated because of:: (A) Rapid metabolism in the CNS, (B) Quick first-pass elimination, (C) Redistribution, (D) Rapid metabolism in systemic circulation
Answer is C. Thiopentone is a ultra sho acting barbiturates ,its action is terminated because of redistribution . thiopentone is highly lipid soluble ,after i.v injection consciousness is regained in 6-10 minutes due to redistribution ,while the ultimate disposal occurs by metabolism. Greater the lipid solubility of the drug ,faster is its redistribution. Ref: KD Tripathi 8th ed