Pulmonary fibrosis is associated with the use of which of the following drugs?: (A) Bleomycin, (B) Cisplatin, (C) Methotrexate, (D) Actinomycin D
Answer is A. Out of all the options given bleomycin and methotrexate can cause pulmonary toxicity. But pulmonary fibrosis is the most feared complication of Bleomycin. Ref: Harrison's 16th Edition, Page 471 (table 70-2); Drug-Induced Diseases: Prevention, Detection, and Management, By James E. Tisdale, Douglas A. Miller, Page 360, table 21-1 (ASHP, 23-Jan-2010)