Which one of the following is a tyrosine tRNA analogue that causes premature chain termination?: (A) Cycloheximide, (B) Puromycin, (C) Paromomycin, (D) Erythromycin
Answer is B. Puromycin Structural analogue of tyrosinyl tRNA. Incorporated into nascent protein chains by a nonhydrolyzable peptide bond. Growing of the peptide bond is inhibited. Inhibits protein synthesis in both prokaryotes and eukaryotes Causes premature chain termination