Which of the following is seen in eosinophil granules?: (A) Cathepsin, (B) Major basic protein, (C) Transferrin, (D) All of the above
Answer is B. Eosinophils are abundant in immune reactions mediated by IgE and in parasitic infections. A chemokine that is especially impoant for eosinophil recruitment is eotaxin. Eosinophils have granules that contain major basic protein, a highly cationic protein that is toxic to parasites but also causes lysis of mammalian epithelial cells. Ref: Robbins 8th edition, Chapter 2.