Inhibition of 5- lipoxygenase is useful in:: (A) cardiac failure, (B) bronchial asthma, (C) hepatic failure, (D) arthritis
Answer is B. Ans. is 'b' i.e. Bronchial Asthma 5 Lioxygenase acts on Arachidonic acid to release leukotrienes which are important inflammatory mediators. They are responsible for the bronchospasm during asthma attack.So as obvious any drug which inhibits 5 lipoxygenase will prevent the formation of Leukotrienes and will be useful in the t/t of Asthma.Zileuton* is a 5 lipoxygenase inhibitor which is being currently used in USA. It is a bronchodilator that reduces asthma morbidity and is effective in exercise induced asthma.