All of the following are features of Zollinger-Ellison syndrome except:-: (A) Intractable peptic ulcers, (B) Severe diarrhea, (C) Arise from beta cell tumors of pancreas, (D) Very high acid output
Answer is C. ZESaAKA Gastrinoma - arise from G- cells/ Gastrin producing cells Has increased gastrin production causing increased acid production- leads to peptic ulcer disease Causes of diarrhea: -Acid produced reaches duodenum and inactivate pancreatic enzymes(works only in alkaline ph) causing Malabsorption -Acid reaches proximal jejunum and causes irritation- leads to jejunal secretion