Which antibodies in mother with SLE is responsible for congenital heart disease in child-: (A) Anti-histone, (B) Anti-Ro & Anti-LA, (C) Anti ds DNA, (D) Anti-centromere
Answer is B. Most sensitive → Antinuclear antibody (ANA)
Most specific → Anti-double stranded antibody and the antibody against Smith (Sm)
Associated with neonatal lupus and congenital heart block → Anti Ro, Anti LA antibody
Associated with lupus psychosis → Anti P antibody