All of the following genes may be involved in development of carcinoma of colon Except: (A) APC, (B) Beta-Catenin, (C) K-ras, (D) Mismatch Repair Genes
Answer is B. .Detection of mutations in congenital conditions like von - Hippel - Lindau disease (vHL gene); haemochromatosis (HFE gene); colorectal carcinoma(APC gene).Familial gastric cancer in associated with mutation of e-cadherin gene (90% risk). It causes hereditary diffuse gastric cancer. Relatives of such family show mutation of this gene. Whether prophylactic total gastrectomy is needed or not in these high risk individuals is a debate. ref:SRB&;s manual of surgery ,ed 3,pg no 777