Tranylcyprominle (MAO Inhibitor) should be avoided with ............... as it causes dangerous drug interaction:: (A) Morphine, (B) Amitriptyline, (C) Alprazolam, (D) Alprazolam
Answer is B. MAO inhibitor with tricyclcic anti depressants (amitriptyline), reserpine , guanethidine can cause excitement , rise in BP and body temperature. This is due to their initial NA releasing it uptake blocking action. MAO inhibitor also interacts with cold and cough remedies that contain sympathetomimetic , levodopa , barbiturates, alcohol, opiod and antihistamine and antiparkinsonian anticholinergic . REF: KD Tripati 8th edition