Causes of severe hypokalemic metabolic alkalosis with severe hypeension include: (A) Liddle syndrome, (B) Bater syndrome, (C) Gitelman syndrome, (D) Renal tubular acidosis
Answer is A. Liddle syndrome - AD, gain-in-function mutations of ENaC subunits. Activating kidneys to excrete potassium retaining excessive sodium & water, leading to hypeension. C/F- severe hypeension with hypokalemia, unresponsive to spironolactone yet sensitive to amiloride