Loss of 'Y' chromosome is associated with which of the following types of renal cell carcinoma (RCC)?: (A) Clear cell RCC, (B) Papillary RCC, (C) Chromophobe RCC, (D) Collecting duct RCC
Answer is B. Papillary RCC accounts for 10% to 15% of renal cancers. It is characterized by a papillary growth pattern. The most common cytogenetic abnormalities are:- Trisomies 7 and 17 Loss of Y in male patients in the sporadic form Trisomy 7 in the familial form. These tumors are not associated with 3p deletions.