Familial polyposis coli is associated with following genetic defect?: (A) MLH1, (B) MSH2, (C) APC, (D) RET
Answer is C. Ans is ;c' i.e., APC * Familial adenomatous polyposis (FAP) syndrome (familial polyposis coli) is caused by mutation in adenomatous polyposis coli gene(APC) located on long arm of chromosome 5 (5q21). Risk of malignancy is 100%, i.e. all patients develop colorectal carcinoma if left untreated.