Gilbe syndrome, true all except -: (A) Causes cirrhosis, (B) Autosomal dominant, (C) Normal liver function test, (D) Normal histology
Answer is A. Ans. is 'a' i.e., Causes cirrhosisGilbe's Syndrome: -o It is an autosomal dominant condition.o It is characterized by unconjugated hyperbilirubinemia (normally the bilirubin is transpoed into liver cells by intracellular proteins. In the liver bilirubin is conjugated. This conjugation is brought about by ceain enzymes. In Gilbe's syndrome these enzymes are absent which cause unconjugated hyperbilirubinemia).The hyperbilirubinemia is usually precipitated by following conditions -- Stress, Fatigue, Alcohol use, reduced calorie intake, intercurrent illness.The hepatic biochemical tests are normal except for elevated bilirubin level (serum bilirubin concentration are usually < 3mg/dI)The hepatic histology is normalThere is no association with cirrhosis.