Which of the following parameters is not monitored in a patient on methotrexate therapy?: (A) Liver function tests, (B) Lung function test, (C) Eye examination, (D) Hemogramz
Answer is C. Ans. (C) Eye examination(Ref: CMDT 2010, 1501)Methotrexate toxicities include:MyelosuppressionNephrotoxicityHepatotoxicityNeurotoxicity (with intrathecal administration and high-dose therapy)PhotosensitivityPulmonary toxicityMultiple drug interactions which may enhance toxicities (avoid aspirin, penicillins, NSAIDs, omeprazole, TMP-SMZ)