Causes of reduced bioavailability of a drug includes: (A) High first pass metabolism, (B) Increased absorption, (C) IV drug administration, (D) High lipid solubility
Answer is A. When the metabolism of a drug is high during its passage from the site of absorption into the systemic circulation, the rate, and extent of absorption of that drug decreases. absorption- amount of drug reaching the systemic circulation from the site of administration (Ref.Essentials of medical pharmacology TD Tripathi 7th edition page no.16,27)