A 10 yr old boy with mass in the abdomen. On imaging the paraaortic LN is enlarged. On biopsy starry sky appearance is seen. What is the underlying abnormality?: (A) p53 gene mutation, (B) RB gene mutation, (C) Translocation involving BCR-ABL genes, (D) Translocation involving MYC gene
Answer is D. Ans. (d) Translocation involving MYC gene(Ref: Robbins 9th/pg 597; 8th/607)Macrophages with abundant clear cytoplasm showing: characteristic "starry sky" pattern are seen in Burkitt lymphoma