The most impoant determinant of prognosis of a patients with Wilms tumor is:: (A) Stage of disease, (B) Histology, (C) Loss of chromosome 1p, (D) Age of presentation
Answer is B. Most impoant factor for prognosis of Wilm's tumor is Histology. Higher the degree of anaplasia - Poorer the prognosis. Presence of anaplasia associated with p53 gene mutation isresponsible for adverse prognosis.