In which of the following conditions would the Coisol level be highest?: (A) Addisons disease, (B) Normal person after giving dexamethasone, (C) Normal person after weakening in morning, (D) Late evening
Answer is C. The secretory rates of CRF, ACTH, and coisol are high in the early morning but low in the late evening. Addison's diseaseresults from an inability of the adrenal coices to produce sufficient adrenocoical hormones. Persons with Addison's disease havediminished secretion of both glucocoicoids (coisol) and mineralocoicoids (aldosterone). Cushing's syndrome- associated with elevated levels of coisol.