High hepatic first-pass metabolism is seen in all EXCEPT: (A) Insulin, (B) Propranolol, (C) Lignocaine, (D) Nitroglycerin
Answer is A. - Except for Insulin, all the three options undergo high first pass metabolism.
- Drugs showing high first pass metabolism

   Isoprenaline
   Lidocaine
   Hydrocortisone
   Testosterone
   Propranolol
   Verapamil
   Salbutamol
   Morphine
   Pethidine