All are true statements about anticancer drugs except?: (A) Vincristine is a marrow sparing anticancer drug, (B) Irinotecan is a topoisomerase II inhibitor, (C) L-asparaginase can cause acute pancreatitis, (D) Anthracyclines cause cardiotoxicity
Answer is B. Anthracyclines cause cardiotoxicity, prevented by dexrazoxane Bleomycin causes pulmonary fibrosis L-asparaginase cause allergy, acute pancreatitis Vincristine, vinblastine causes peripheral neuropathy & SIADH. But it is marrow sparing. Irinotecan is a topoisomerase I inhibitor used for colorectal carcinoma Topoisomerase II inhibitors are Etoposide, doxorubicin, Daunorubicin & anthracyclines.