Transient acute adrenal insufficiency is seen with which of the following drug.: (A) Etomidate, (B) Propofol, (C) Thiopentone, (D) Ketamine
Answer is A. Etomidate causes adrenal gland suppression. It inhibits an enzyme 11 beta hydroxylase on essential enzyme for coisol synthesis. Etomidate has the highest incidence (40%) of post operative nausea and vomiting (PONV) among the intravenous anesthetics. Propofol has antiemetic propeies thereby reducing PONV. Other potential adverse effects of etomidate: Adrenocoical suppression Myoclonus Seizure precipitation Pain on injection