Which of the following is not a major criteria for diagnosis of multiple myeloma ?: (A) Lytic bone lesions, (B) Plasmacytoma on tissue biopsy, (C) Bone marrow plasmacytosis > 30%, (D) `M' spike > 3g% for 1g G, > 2g% for IgA
Answer is C. In the NCCN guidelines, active multiple myeloma is no longer diagnosed using the CRAB criteria (hyperCalcemia, Renal failure, Anemia, Bone lesions) for end-organ damage. The current diagnostic criteria are as follows : Bone marrow clonal plasma cells >=10% or bony or extramedullary plasmacytoma (confirmed by biopsy)