Michalis Gutmann bodies are seen in: (A) Xanthogranulomatous pyelonephritis, (B) Malakoplakia, (C) Nail patella syndrome, (D) Chronic pyelonephritis
Answer is B. Malakoplakia *Etiology : Inflammation due to chronic bacterial infection, mostly by E.coli and proteus.*Common in immunosuppressed individuals*Pathogenesis : Disturbed phagocytic activity due to overloaded bacteria within macrophages*Sites : Urinary bladder, Colon, Lungs,Bones, Kidneys, prostate and epididymis *Microscopic findings : Sheets of macrophages, giant cells and michaelis-gutmann bodies *Michaelis gutmann bodies - Laminated mineralized concretions resulting from deposition of calcium In enlarged lysosomes of macrophages (Ref: Robbins 8/e p975)