Crohn's disease is associated with polymorphisms in: (A) NOD2/CARD 15 gene, (B) P53 gene, (C) Philadelphia chromosome, (D) APC/Beta catenin
Answer is A. Individuals with allelic variants of CARD15/NOD2 have a 40 fold relative risk for Crohn's disease compared with general population. Reference : Sabiston Textbook of Surgery, 19th Edition, page no = 1245.