Skip lesions are seen in: (Repeat): (A) Crohn's disease, (B) Ulcerative colitis, (C) Ischemic bowel disease, (D) Typhoid colitis
Answer is A. Ans: A (Crohn's disease) Ref: Harrison's Principles of internal Medicine, 18ed.Explanation:Crohn's diseaseMC site-terminal ileum with rectal sparing, skip areas +It is transmural, hence more of fistula formationMore of systemic symptoms, pain, abdominal massToxic megacolon- PerforationIntraabdominal abscess, fallopian tube scarring - infertilityIntestinal obstruction, massive hemorrhage, malabsorption, severe perianal diseaseCobblestoning on endoscopeResponds to antibiotics, recurs after surgeryASCA-positiveTreatment - Antibiotics, corticosteroids, sulfasalazine, mercaptopurine. azathioprine, methotrexate, cyclosporine, tacrolimusAnti-TNF: Infliximab, adalimumab, certolizumab pegolAnti-integrin: NatalizumabRisk of Ca increases with duration & severity of the disease