Ivermectin act by ?: (A) Inhibition of pyruvate ferridoxin oxidoreductase, (B) Inhibition of Nicotinic Acetycholine receptor, (C) Activation of Glutamate gated Chloride channels, (D) Inhibition of heme polymerase
Answer is C. Ivermectin : MOA :induce paralysis by activating Glutamate-gated Cl- channels foundonly in Inveebrates(Nematode nerve or muscle cells) and causes hyperpolarizationby increasing intracellular Chloride concentration, resulting in paralysis.It also binds with high affinity to GABA-gated and other ligand-gated Cl- channels in nematodes such as Ascaris . USES: It is drug of choice for Strongyloidiasis and Onchocerciasis. It is also useful for Ascariasis, Enterobiasis, Cutaneous Larva Migrans and Uncomplicated Scabies.