RET proto-oncogene is associated with which carcinoma?: (A) Hepatocellular Carcinoma, (B) MEN, (C) Testicular carcinoma, (D) Breast carcinoma
Answer is B. Ans. is 'b' i.e., MEN * RET is a growth factor receptor (receptor tyrosine kinase). RET protein is a receptor for glial cell lined derived neurotrophic factor. RET is normally expressed in parafollicular 'C' cells of thyroid, adrenal medulla and parathyroid cell precursons.* Point mutation in RET protooncogenes is associated with MEN-2A, MEN-2B, medullary thyroid carcinoma and Hirschsprung disease.