Which among the following is an antibiotic agent that penetrates burn eschar to reach interface with patient's ble tissue ?: (A) Mafenide acetate, (B) Neomycin, (C) Silver nitrate, (D) Silver sulfadiazine
Answer is A. Mafenide acetate Antibiotic agent that penetrates burn eschar to reach interface with patient's ble tissue. Disadvantages- Quite painful on any paial thickness areas, and it is a carbonic anhydrase inhibitor that interferes with renal buffering mechanisms. Chloride is retained & metabolic acidosis can occur. For these reasons, silver sulfadiazine is more commonly used in burn centers unless a major problem with burn wound sepsis is present.