Which of the following drugs used to treat MDR TB can cause hypothyroidism:: (A) Kanamycin, (B) Pyrazinamide, (C) Ethionamide, (D) None of the above
Answer is C. Adverse effects of Ethionamide Gastro-intestinal: epigastric discomfo, anorexia, nausea, metallic taste, vomiting, excessive salivation, and sulfurous belching Psychiatric: hallucination and depression Hepatitis Hypothyroidism and goitre with prolonged administration Gynaecomastia, menstrual disturbances, impotence, acne, headache, and peripheral neuropathy Ref: