Carbamoyl phosphate synthase - 1 is stimulated by ?: (A) ATP, (B) Arginosuccinate, (C) Carbamoyl phosphate, (D) N-acetyl glutamate
Answer is D. Carbamoyl phosphate synthase-I (CPS-I), a mitochondrial enzyme, catalyzes the formation of carbamoyl phosphate by condensation of CO2 and ammonia.Two molecules of ATP are required for the reaction. CPS-I is the rate limiting enzyme of urea cycle. It is an allosteric enzyme and allosterically activated by N-acetyl glutamate.