Orotic aciduria is due to deficiency of: (A) Decarboxylase, (B) Tyrosinase, (C) Isomerase, (D) Homogentisate oxidase
Answer is A. Orotic aciduria an autosomal recessive disorder, can be caused by a deficiency in the enzyme UMPS, a bifunctional protein that includes the enzyme activities of orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase.