Acquired mutations in PIGA  gene gives rise to :: (A) Paroxysmal Nocturnal Hemoglobinuria, (B) Hereditary Spherocytosis, (C) Isoimmune hemolytic anemia, (D) Fanconi’s anemia
Answer is A. Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic anemia that stems from acquired mutations in PIGA, a gene required for the synthesis of phosphatidylinositol glycan (PIG), which serves as a membrane anchor for many proteins. Because PIGA is X-linked, normal cells have only one active PIGA gene, a mutation of which is sufficient to cause PIGA deficiency.