Transketolase activity is seen with which vitamin: (A) Vit B1, (B) Vit B2, (C) Vit B3, (D) Vit B4
Answer is A. Transketolase activity is seen in Vit B1. In thiamine deficiency, blood thiamine is reduced, but pyruvate, alpha-ketoglutarate and lactate are increased. Erythrocyte transketolase activity is reduced; this is the earliest manifestation seen even before clinical disturbances. Ref: DM Vasudevan - Textbook of Biochemistry, 6th edition, page no: 392