Method of prevention of GVHD in bone marrow transplantation is:: (A) T-cell removal, (B) Prior immune suppression, (C) Post procedure immune suppression, (D) All of the above
Answer is D. The following are the steps taken to reduce the risk of graft versus host disease: Getting the best donor match: donor is as closely matched to recipient with the technique of tissue typing. Use of immunosuppressive drugs like ciclosporin, tacrolimus etc T cell depletion: Removal of T cells from the donor's bone marrow is called as T cell depletion. Post procedure immune suppression using the drugs like methotrexate and cyclophosphamide.