Intranuclear viral inclusions are seen in tissue specimens of which of the following?: (A) Solar cheilitis, (B) Minor aphthous ulcers, (C) Geographic tongue, (D) Hairy leukoplakia
Answer is D. Hairy leukoplakia is viral in origin and shows intranuclear inclusions in infected epithelial cells. Hairy leukoplakia is caused by Epstein–Barr virus, a herpes virus. Intranuclear epithelial inclusions are also seen in other herpes virus infections (e.g., herpes simplex virus infections).