All of the following are true regarding diuretics except:-: (A) Spironolactone is a potassium sparing drug, (B) Mannitol is an osmotic diuretic, (C) Thiazides act by inhibiting sodium-potassium chloride co-transpo, (D) Acetazolamide inhibits carbonic anhydrase enzyme
Answer is C. Name Site of action Example Mechanism Loop diuretics Thick ascending limb of Loop of Henle Furosemide Torsemide Na-K-2Cl sympoer inhibition Carbonic anhydrase inhibitors PCT Acetazolamide Dorzolamide Brinzolamide Carbonic anhydrase inhibition Thiazides DCT Hydrochlohiazide Chlohalidone Na-Cl sympoer inhibition Osmotic diuretics Non-specific Mannitol By osmotic effect Epithelial sodium channel blockers Collecting duct Amiloride Triamterene eNa channel blockade Aldosterone antagonists Collecting duct Spironolactone Epleronone Antagonism of aldosterone receptors