Which of the following enzymes is known as 'suicide enzyme'?: (A) Cyclooxygenase, (B) Lipoxygenase, (C) Phospholipase C, (D) Xanthine oxidase
Answer is A. Cyclooxygenase can switch off the synthesis of prostaglandins by undergoing self-catalysed destruction. That is why this enzyme is known as suicidal enzyme. (Do not confuse this with suicidal inhibition). Cyclooxygenase aka prostaglandin H synthase Bifunctional enzyme with two activities - cyclooxygenase and peroxidase. There are two isoenzymes of cyclooxygenase, COX-1 (Constitutive) and COX-2 (Inducible).