Which one of the following is false regarding primary adrenal hyperplasia?: (A) Hyponatremia, (B) Hypernatremia, (C) Water retension, (D) Hypokalemia
Answer is A. Primary adrenal hyperplasia leads to increased mineralocoicoid activity and hence sodium and water retention with increased potassium excretion. Primary adrenal hyperplasia (PAH) is a clinical finding that can only be realized after surgery. Findings of PAH include severe hypokalemia and hypeension responsive to spironolactone, and elevated supine plasma aldosterone and 18-hydroxycoicosterone values that did not increase after ambulation.