All of the following are helpful for diagnosis of medullary Ca thyroid except -: (A) Spindle cell stroma with few follicles, (B) Amyloid deposition, (C) Calcitonin in stroma, (D) Histological mitochondria is essential for diagnosis
Answer is D. Important Diagnostic Features of Medullary carcinoma are :
Acellular amyloid deposition.
Calcitonin secretion by tumour cells.
Microscopically polygonal to spindle cell may form nests, trabeculae and even follicles.
Electron Microscopy showing variable no. of electron-dense granules (Membrane-bound) within the cytoplasm.