Sulfasalazine exes its primary action in ulcerative colitis by :: (A) Folic acid synthesis, (B) Formation of prostaglandins (PG), (C) Inhibition of NF-KB Activation, (D) Formation of interleukins
Answer is C. MOA* Inhibition of NF-KB Activation* Inhibition of PG synthesis* Scavenging of Free radicals 5-ASA compounds exe its local anti-inflammatory effect by inhibiting leukotriene production (PG synthesis) by inhibition of 5-lipooxygenase activity; also inhibits the production of IL-1 and TNF. Commonly Used 5-ASA Formulations in IBD Sulfasalazine Oral mesalamine agents Azo compounds: Balsalazide, Olsalazine