Thiazide diuretics act on:: (A) PCT mainly, (B) DCT mainly, (C) Loop of henle, (D) All part of tubule
Answer is B. Ans. B DCT mainlyDiuretic classDrugsMOASite of actionOsmotic diureticMannitolInhibit water and solute reabsorptionAll part of tubule, but mainly proximal tubuleLoop diureticsFurosemide TorsemideInhibit Na+-K+-2Cl- transportThick ascending loop of henleThiazide diureticHydrochlorothi azide Benzthiazide Chlorthalidone IndapamideInhibit Na+-Cl- co-transportDistal tubuleK+ sparing diureticSpironolactoneTriamtereneAmilorideDecrease Na+ reabsorption Decrease K+ secretionCollecting tubuleCarbonic anhydrase inhibitorAcetazolamideInhibit H+ secretion and HCO3 reabsorption, whichreduces Na+ reabsorptionProximal tubule