What happens to hepcidin levels in Anemia of chronic disease: (A) Increases, (B) Decreases, (C) Remains normal, (D) Any of the above
Answer is A. In anemia of chronic disease due to release of cytokines IL-6, TNF-α, IL - 1, (as a result of chronic inflammation) hepcidin synthesis increases in the liver.
Hepicidin inhibits iron release from macrophages.