A 1-year-old girl presents with a 2-day history of fever, vomiting and watery, non-bloody diarrhoea. O/E, she appeared dehydrated. Which of the following best describes the most likely infecting organism?: (A) It has partially ds-circular DNA genome, (B) It has segmented ds-circular RNA genome, (C) It has a ss-circular RNA genome, (D) It has a ss-RNA genome
Answer is B. Ans. B. It has segmented ds-circular RNA genomeRota virus* Genome: 11 segments of ds RNA* Resemble wheel with short spokes* 7 major groups: A-GPathogenesis:- Destruction of enterocytes- Enterotoxin- Enteric neuron activationLab diagnosis:-. Detection of viral antigen in stool- IgM/IgG ab- PCR