Prompt pump inhibitor suppress gastric acid secretion by acting on:: (A) H+/ Cl- ATPase pump, (B) H+/ K+ ATPase pump, (C) Na+ / K+ ATPase pump, (D) Na+ / K+ /Cl-ATPase pump
Answer is B. PPIs(proton pump inhibitor): - Irreversible inhibitors- Example of HIT and RUN drugs- Exes systemic effect: normally acid labile, given with acid resistant coating.- DOC for: PUD, GERD, Zollinger Ellison syndrome- Prompt pump inhibitor suppress gastric acid secretion by acting on H+/K+ pump. Side effect: (chronic use): - Osteoporosis(decrease calcium)- Megaloblastic anemia(decrease vitamin B12)- Infection