Which of the following statements about vigabatrin is TRUE?: (A) Blocks neuronal reuptake of GABA, (B) Drug of choice in absence seizures, (C) Life threatening skin disorders may occur, (D) Visual disturbances can occur
Answer is D. (Ref: KDT 6/e p410) Vigabatrin act by inhibiting the enzyme GABA transaminase (involved in breakdown of CABA). It is used for the treatment of paial and generalized seizures. It is also used to treat infantile spasms. Visual disturbances are very impoant adverse effect of this agent.