Bleomycin toxicity affects which type of cells :: (A) Type–I pneumocytes, (B) Type–II pneumocytes, (C) Endothelial cells, (D) Pulmonary alveolar macrophages
Answer is A. Bleomycin causes necrosis of Type I pneumocytes that results in compensatory hyperplasia of type-II pneumocytes. The same kind of injury can also occur in response to radiations. In experimental models, this type of injury has been ameliorated by keratinocyte growth factor.