Acquire IgA deficiency may occur in ?: (A) Severe Congenital toxoplasmosis, (B) Severe Measles infection, (C) Severe Brucellosis, (D) Severe Leptospirosis
Answer is A. Severe Congenital toxoplasmosis Block in B cell differentiation due to defective interaction between T and B cells. Naive B cells are not able to differentiate into IgA - producing cells.