TNF -alpha inhibitors should not be used in:: (A) Rheumatoid ahritis with HIV infection, (B) Rheumatoid ahritis with hepatitis B, (C) Rheumatoid ahritis with hepatitis C, (D) Rheumatoid ahritis with pulmonary fibrosis
Answer is B. Tumor necrosis factor-a (TNF-a) inhibitors are known to increase reactivation of concurrent chronic hepatitis B,Hence not used ESSENTIALS OF MEDICAL PHARMACOLOGY: SEVENTH EDITION K.D TRIPATHI PAGE:804,805,884