The flipped pattern of LDH isoenzymes occur in -: (A) Myositis, (B) Myocardial infarction, (C) Grave's disease, (D) Myasthenia gravis
Answer is B. LDH-2 is usually the predominant form in the serum. An LDH-1 level higher than the LDH-2 level (a "flipped pattern") suggests myocardial infarction (damage to hea tissues releases hea LDH, which is rich in LDH-1, into the bloodstream). The use of this phenomenon to diagnose infarction has been largely superseded by the use of Troponin I or T measurement Ref: https://en.wikipedia.org/wiki/Lactate_dehydrogenase