Not true about Fosphenytoin: (A) Used for GTCS, (B) Prodrug of Phenytoin, (C) Lipid soluble, (D) Highly protein bound
Answer is C. Fosphenytoin, a more soluble phosphate prodrug of phenytoin, is well absorbed. Fosphenytoin sodium is available for intravenous or intramuscular use and replaces intravenous phenytoin sodium, a much less soluble form of the drug. Used in generalized Tonic-clonic seizures and paial seizures. Highly bound to plasma proteins.Reference: Katzung Pharmacology; 13th edition; Chapter 24; Antiseizure Drugs