All of the following statement about pralidoxime in organophosphate poising are true except: (A) It is given Intravenously, (B) It should be staed after 24 hrs. of poisoning, (C) Does not cross blood brain barrier, (D) Reactivates AchE enzyme
Answer is B. - Oximes are given for the reactivation of the inhibited Acetylcholinesterase in OPC poisoning - Two oximes which are used : * PAM (Pralidoxime) : does not cross blood brain barrier * DAM (Diacetyl mono-oxime) : crosses blood brain barrier, both central and peripheral action - Oximes should be staed as soon as possible after atropine is given , if we take long time then enzyme aging may occur (enzyme cannot work)