Which of the viruses is not commonly implicated in the pathogenesis of Non-Hodgkin's lymphomas?: (A) Human T-cell leukemia virus-1 (HTLV-1), (B) Epstein-Barr virus (EBV), (C) Human herpesvirus-8 (HHV-8), (D) Cytomegalovirus (CMV)
Answer is D. HTLV-1 is associated with adult T-cell leukemia/lymphoma. EBV is found in a subset of Burkitt lymphoma, 30% to 40% of Hodgkin lymphoma (HL), many B-cell lymphomas arising in the setting of T-cell immunodeficiency, and rare NK-cell lymphomas. In addition to Kaposi sarcoma, HHV-8 is associated with an unusual B-cell lymphoma (primary effusion lymphoma) that presents as a malignant effusion, often in the pleural cavity.