Mechanism of action of paclitaxei is -: (A) Topoisomerase inhibition, (B) Increase the polymerization of tubulin, (C) Inhibition of protein synthesis, (D) Alkylation of DNA
Answer is B. Ans. is 'b' i.e., Increase the polymerization of tubulin Tasaneso Pacliiaxel and docetaxei function as a mitotic spindle poison through high affinity' binding to microtubules with enhancement of tubulin polymerization.o The microtubules are stabilized and their depolymerization is prevented - inhibition of mitosis and cell division.o Paclitaxel is metabolized in liver and undergoes enterohepatic circulation - dose should be reduced in liver dysfunction.o Paclitaxel can cause hypersensivitv reaction which does not occur with a novel albumin-bound paclitaxel preparation.o Paclitaxel and docetaxei both can cause bone marrow depression & peripheral neuropathy.