All of the following are risk factors for malignant change in a gall bladder polyp, except:: (A) Age > 60 years, (B) Rapid increase in size of polyp, (C) Size of polyp > 5 mm, (D) Associated Gall stones
Answer is C. Risk factors for malignant change in an asymptomatic patient with a gall bladder polyp are: polyp size greater than 10mm, age >50years, and presence of gallstones. There is greater risk of malignancy in polyps in patients with primary sclerosing cholangitis. Endoscopic ultrasound helps in differentiating cholesterol polyps from malignant polyps. Ref: Sherlock's Diseases of The Liver and Biliary System By James S. Dooley, Page 277; Diseases of The Gallbladder and Bile Ducts: Diagnosis and Treatment By Pierre-Alain Clavien, John Baillie, John Baillie (FRCP (Glasg.)), Page 49