Ram Prasad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and vd of tobramycin in him are 160ml/min and 40L ,respectively.if you wish to give Ram Prasad and intravenous loading dose to achieve the therapeutic plasma concentration of 4mg/L rapidly, how much should be given: (A) 0.1mg, (B) 10mg, (C) 115.2mg, (D) 160mg
Answer is D. Ref-Katzung 10/e p45 Loading dise= Vd xtarget Plasma concentration =40Lx4mg/L =160mg clearance plays no role in the determination of loading dose. it is given to confuse you