All are true about warfarin, except: (A) It inhibits the activation of vitamin K dependent cloting factors, (B) Its half life is 36 hours, (C) It can cross placenta, (D) Its dose is increased in liver disease
Answer is D. It&;s dose should be reduced in liver and renal impairment as it is metabolized by glucoronide conjugation and is excreted by urine. From medical pharmacology padmaja 4th edition Page no 339,341