Amifostine protects all of the following except:: (A) CNS, (B) Kidneys, (C) Salivary glands, (D) GIT
Answer is A. Amifostine It is a prodrug that is dephosphorylated by alkaline phosphatase in tissues to a pharmacologically active free thiol metabolite Cause reduction of the cumulative renal toxicity of cisplatin and toxic effects of radiation on normal oral tissues Amifostine protects -Kidneys - Salivary glands - GIT