Which of the following statements about baricitinib is FALSE?: (A) Oral JAK inhibitor, (B) Approved for use in moderate to severe Crohn's disease, (C) Increases triglycerides, (D) Dose reduction is required in renal and hepatic impairement
Answer is B. Baricitinib andtofacitinib are oral JANUS kinase inhibitors (JAK). These drugs are used in rheumatoid ahritis.Tofacitinib is also used in ulcerative colitis. Major side-effects of these drugs are:* Increased risk of infection: TB , Herpes zoster.* Increased risk of malignancy like Lymphoma.* Hyperiglyceridemia.They require dose reduction in kidney and liver failure. So, they are avoided in lymphopenia and anemia.So, the answer is 'B' because it is not used in Crohn's disease.