Interferon-gamma release assays used to diagnose tuberculosis is :: (A) T-SPOT.TB, (B) B-SPOT.TB, (C) NIGRAs, (D) C-SPOT.TB
Answer is A. Two in vitro assays that measure T cell release of IFN with the highly TB-specific antigens ESAT-6 and CFP-10 are available. The T-SPOT.TB is an enzyme-linked immunospot (ELISpot) assay, and the QuantiFERON-TB Gold.