The propoion of which of the acids are increased in acne comedones?: (A) Linolenic acid, (B) Palmitic acid, (C) Acetic acid, (D) Linoleic acid
Answer is B. In acne comedones the propoion of linoleic acid is markedly decreased, while palmitic acid is significantly increased. Decreased propoion of linoleic acid, markedly suppresses neutrophil reactive oxygen species (ROS) generation and phagocytosis and contribute to the worsening of acne inflammation.