Which of the following inhalational agent is contraindicated in renal disease?: (A) Methoxyflurane, (B) Sevoflurane, (C) Desflurane, (D) Isoflurane
Answer is A. Methoxyflurane produces inorganic fluoride, which was responsible for the sporadic incidence of nephrotoxicity (i.e., high-output renal failure) after prolonged anesthesia Basics of anesthesia 7e pg:95