Most common carcinoma associated with RA: (A) Diffuse large B cell lymphoma, (B) Large granular lymphocytic leukemia, (C) Chronic lymphocytic leukemia, (D) None
Answer is A. Large coho studies have shown a two- to fourfold increased risk of lymphoma in RA patients compared with the general population. The most common histopathologic type of lymphoma is a diffuse large B cell lymphoma. The risk of developing lymphoma increases if the patient has high levels of disease activity or Felty's syndrome. Ref Harrispns 20e p2530