All adverse effects of theophylline are mediated by A1, receptor except:: (A) Cardiac arrhythmias, (B) Dieresis, (C) Seizures, (D) GI discomfo
Answer is D. Theophylline exes it's bronchodilation effect by PDE inhibition effect and Adenosine A1 antagonism. It has multiple side effect : Nausea and vomiting PDE inhibition Headache PDE inhibition Gastric discomfo PDE inhibition Diuresis Adenosine A1 antagonism Arrythmias PDE inhibition, A 1 antagonism Seizures Adenosine A1 antagonism