The immunosuppressant action of cyclosporin appears to be due to: (A) Activation of NK cells, (B) Blockade of tissue response to inflammatory mediators, (C) Inhibition of Gene transcription of interleukin, (D) Interference with antigen recognition
Answer is C. Ref-KDT 6/e p838,839,840 Cyclosporine and tacrolimus acts by inhibiting calcineurin, which is involved in the activation of NFAT. Final result of this process is increased transcription of IL-2 gene. Sirolimus does not inhibit the transcription of IL-2 but interferes with its action. It inhibits the enzyme tyrosine kinase, known as mTOR (which is activated by IL-2).