Hereditary retinoblastoma develop as a result of which of the following chromosomal deletion?: (A) 13q 14, (B) 13p 14, (C) 14p 13, (D) 14q 13
Answer is A. Hereditary retinoblastomas develop from the deletion of Rb gene, located on chromosome 13q14. Retinoblastoma gene is a tumor suppressor gene, which serves as a break on the advancement of cells from the G1 to S phase of cell cycle.Ref: Robbins Pathologic Basis of Disease, 7th Edition, Pages 287, 289, 1372.