Most common type of inherited disease of hypercoagulobility is?: (A) Protein C deficiency, (B) Leiden mutation, (C) DIC, (D) Antithrombin III deficiency
Answer is B. Ans. is 'b' i.e., Leiden mutation * Of the inherited causes of hypercoagulability, mutation in factor V gene is the most common.* Factor V mutations (called the leiden mutation) causes subsitution of arginine residue (at position 506) by glutamine.* This mutation makes factor V resistant to cleavage by protein 'C* (normally protein 'C is one of the factor that regulates coagulation by inactivating factor V & VIII).* This results in unchecked coagulation.