Which of the following antibodies is most frequently seen in Antiphospholipid Syndrome? -: (A) Anti- beta 2 glycoprotein antibody, (B) Beta 2 microglobulin antibody, (C) Anti-nuclear antibody, (D) Anti-centromere antibody
Answer is A. Antiphospholipid antibody syndrome has clinical manifestations including recurrent thrombosis,  repeated miscarriages,  cardiac valve vegetations and thrombocytopenia. Suspected Ab target include Beta 2 Glycoprotein 1, a plasma protein that associates with the surfaces of endothelial cells and trophoblasts.
Anti nuclear antibody and beta 2microglobulin Ab  seen in SLE.