A patient's history notes a documented severe reaction to a penicillin. What other antibiotic is likely to cross-react and so should be avoided in this patient?: (A) Aininoglycosides, (B) Azithromycin, (C) Cephalosporins, (D) Erythromycin
Answer is C. Unless there are no reasonable alternatives, cephalosporins should be avoided for patients with prior severe responses to penicillins because of their cross- reactivity. None of the other drugs or drug groups listed here cross-react in penicillin-sensitive patients.