The receptor involved in chemotheraphy induced vomiting is:: (A) Histamine H1 receptor, (B) Serotonin 5-HT3 receptor, (C) Dopamine D2 receptor, (D) Opioid m receptor
Answer is B. Ondansetron:- It is the prototype of the new class of selective 5-HT3 antagonists that have shown efficacy in controlling nausea and vomiting following administration of highly emetic anticancer drugs and radiotherapy. Ref:- kd tripathi; pg num:-175 Ondansetron is the DOC for early vomiting and nausea due to chemotheraphy and radiotherapy.