In G6PD deficiency, which cells are more prone for hemolysis:: (A) Older red cells, (B) Young red cells, (C) Reticulocytes, (D) All are susceptible
Answer is A. - Mature red cells do not synthesize new proteins - Hence, as red cells ages G6PD enzyme levels fall quickly & becomes inadequate to protect against oxidant stress. - Thus, older red cells are much more prone to hemolysis than younger ones.