Preferred insulin regimen during pregnancy?: (A) Insulin Regular + NPH, (B) Insulin NPH + Lispro, (C) Insulin Degludec, (D) Insulin Lispro + Insulin regular
Answer is B. For basalinsulincoverage, intermediate-acting neutralprotamineHagedorn (NPH)insulinhas historically been considered first-line therapy and has been widely studied in this patient population. For postprandial glycemic control, rapid-actinginsulinanalogues, such asinsulinlispro andinsulin aspa, do not cross the placenta and have been safely used in pregnancy.