Leber's optic neuropathy-: (A) Typically presents in the fourth decade of life, (B) Males do not transmit the disease, (C) Is inherited in autosomal X-link fashion, (D) The optic disc is pale early in the disease
Answer is B. Leber's hereditary optic neuropathy is a mitochondrial disorder. Since mitochondrial DNA is exclusively derived from mothers, males do not transmit the disease.
The optic disc becomes pale and atrophic in late atrophic phase (not early).