Which of the following antimicrobial agents do not require reduction in dose in patients with renal failure?: (A) Rifampicin, (B) Fluconazole, (C) Vancomycin, (D) Imipenem
Answer is A. Rifampicin is primarily metabolized in the liver and excreted in bile. Rifampicin does not require dosage adjustment in Renal failure. Ref: Essentials of Medical Pharmacology By K D Tripathi, 5th Edition, Pages 667, 700, 719, 721; KDT 6th Edition, Page 741