Biguanides acts by following except -: (A) |Insulin release from pancreas, (B) | Glycolysis, (C) | Gluconeogenesis, (D) | Insulin binding to its receptors
Answer is A. Ans. is 'a' i.e., | insulin release from pancreash Biguanides acts by : o Suppress hepatic gluconeogenesis and glucose output from liver major action. o Enhance insulin mediated glucose disposal in muscle and fat (Increased peripheral utilization of glucose) by enhancing GLUT-I transpo from intracellular site to plasma membrane. o Retad intestinal absorption of glucose. o Promote peripheral glucose utilization by enhancing anaerobic glycolysis.