Most common side effect of 5-fluorouracil is:: (A) G.I. toxicity, (B) Bone marrow depression, (C) Cardiotoxicity, (D) Neeurotoxicity
Answer is A. (Ref: KDT 6/e p824; Harrison 16/e p596) Diarrhea is the most common adverse effect of 5-FU. It can also cause hand and foot syndrome and bone marrow suppression.