Which of the following ultrastructural finding is more specific for irreversible injury?: (A) Ribosomal detachment from endoplasmic reticulum, (B) Formation of phagolysosomes, (C) Cellular swelling, (D) Amorphous densities in mitochondria
Answer is D. The hallmark ultrastructural features of irreversible cell injury are: cell membrane defects, mitochondrial swelling and calcium accumulation and nulear chromatin clumping. Morphologic forms of reversible cell injury are :Cellular swellingFatty changeHyaline changeMucoid changeUltrastructural changes that occur in hydropic swelling phase of reversible injury are:Dilatation of endoplasmic reticulumDetachment of polysomes from the surface of RERMitochondrial swellingFormation of blebs on plasma membraneLoss of fibrillarity of nucloelus