The normal cellular counterpas of oncogenes are impoant for the following functions, except ?: (A) Promotion of cell cycle progression, (B) Inhibition of apoptosis, (C) Promotion of DNA repair, (D) Promotion of nuclear transcription
Answer is C. o Normal cellular counterpa of oncogene is protooncogene.o The functions of protooncogene is to code forGrowth factorsGrowth factor receptorsProteins involved in signal transductionNeuclear regulatory proteins (transcription factors)Cyclins/CDKso All these lead to cell proliferation and progression of cell cycle.o When any of these protooncogenes becomes oncogene by mutation / overexpression, there is uncontrolled proliferation of cell and development of cancer.This proliferation is autonomous, i.e. without physiological stimulus.