18 year old girl with primary amenorrhea having a karyotype of 45X0 presents with infantile uterus. What should be done next?: (A) B/L gonadectomy, (B) H to induce pubey, (C) Clitoroplasty, (D) Vaginoplasty
Answer is B. Primary amenorrhea with karyotype of 45 XO with an infantile uterus is suggestive of TURNER SYNDROME Management Screen for associated abnormalities: cardiac (30% have coarctation of aoa), renal (esp.horseshoe kidney), autoimmune abnormalities (thyroiditis), diabetes, hypeension and hearing loss Growth hormone therapy: accelerate growth velocity and improves final height Gonadal steroids: sta with estrogen therapy and add progesterones to induce pubey