Which of the following group of drugs follows zero order kinetics with high dose: (A) Phenytoin and Propranolol, (B) Amiloride and probenacid, (C) Alcohol and theophylline, (D) Digoxin and propranolol
Answer is C. drugs which follow zero order kinetics- methanol, ethanol mixed order - 1st order at a low dose and zero order at high dose- aspirin, phenytoin, tolbutamide, digoxin, warfarin, theophylline most of the drugs usually follow 1st order kinetics and they are considered safe drugs Ref: KD Tripathi 8th ed