Volume of distribution is NOT affected by all EXCEPT: (A) Binding to plasma protein, (B) Drug clearance, (C) Lipid insolubility, (D) Absence of blood brain barrier
Answer is A. (Binding to plasma protein) (31-33-KDT 6th)* The extent of distribution of drug depends on* Lipid solubility* Ionization at physiological pH (dependent on pKa)* The extent of binding to plasma and tissue proteins* Differences in regional bloodflow