Apoptosis activating factor 1 (Apaf-1): (A) Activates caspase 9, (B) Activates caspase 8, (C) Activates Bcl-1 and Mcl-1, (D) Binds with mitochondrial cytochrome C
Answer is A. Apaf-1 combines with cytoplasmic cytochrome C that leads to formation of apoptosome complex which further triggers caspase 9 activation. Thus, leading to apoptosis via intrinsic pathway.