Resistance to acyclovir is most commonly due to mutation in the viral gene that encodes a protein that: (A) Conves viral RNA into DNA, (B) Phosphorylates acyclovir, (C) Transpos acyclovir into the cell, (D) Transpos acyclovir out of the cell
Answer is B. Ref-KDT 6/e p768 Nucleoside/tide analogues act by conveing to NTPs. First phosphorylation step occurs inside the virus and resistance occurs if there is mutation in this gene