Mechanism of action of paclitaxel is -: (A) Topoisomerase inhibition, (B) Increases the polymerization of tubulin, (C) Inhibits protein synthesis, (D) Alkylation of DNA
Answer is B. Ans. is 'b' i.e., Increases the polymerization of tubulin o Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. o The microtubules are stabilized and their depolymerization is prevented inhibition of mitosis and cell division.