Aquaporin deficiency cause?: (A) Nephrogenic diabetes insipidus, (B) Liddle syndrome, (C) Baer syndrome, (D) Gitelman syndrome
Answer is A. 1. Nephrogenic diabetes insipidus: Aquaporin 2" gene mutation impede the normal functionality of the kidney water channel, which results in the kidney being unable to absorb water. Autosomal recessivemanner. 2. Liddle syndrome: Gain of function of epithelial Na channel (ENaC) 3. Bater syndrome:- Defect in "Na-K-2Cl cotranspoer, Cl channel & ROMK" in loop of Henle. 4. Gitelman syndrome: Defect in "Na+-Cl- cotranspoer and TRPM6 transpoer" in DCT.