1718. A patient presents with increased serum ferritin, decreased TIBC, increased serum iron, % saturation increased. Most probable diagnosis is -: (A) Anemia of chronic disease, (B) Sideroblastic anemia, (C) Iron deficiency anemia, (D) Thalassemia minor
Answer is B. In the given case,serum iron is raised,which implies that it is not a iron deficiency anemia or anemia of chronic disorder(where serum iron is reduced) In sideroblastic anemia , serum ferritin levels are raised,marrow iron stores are raised,serum iron is usually raised with almost complete saturation of TIBC. The disorder has its pathogenesis in disturbed growth & maturation of erythroid precursors at the level of hematopoietic stem cell,probably due to reduced activity of the enzyme,ALA synthetase. Reference :Harsh mohan textbook of pathology sixth edition pg no 300.