Mechanism of action of propylthiouracil:: (A) inhibition of organification of iodine, (B) inhibition of oxidation, (C) inhibition of coupling, (D) all of the above
Answer is D. Ans. D. All of the aboveThyroid peroxidase enzyme is responsible for oxidation, organification and coupling of thyroid hormone. Thus, propylthiouracil is the inhibitor of thyroid peroxidase enzyme and modulate all the functions.