Which is false about Gilbe syndrome: (A) Male predominant, (B) UGT activity is 10-30 % of normal, (C) Histology normal, (D) Mild conjugated hyperbilrubinemia
Answer is D. Gilbe Syndrome is characterized by mild unconjugated hyperbilirubinemia, normal values for standard hepatic biochemical tests, and normal hepatic histology other than a modest increase of lipofuscin pigment in some patients. Serum bilirubin concentrations are most often <51 mmol/L (<3 mg/dL),UGT (UDP-glucuronosyltransferase 1) activity is typically reduced to 10-35% of normal, and bile pigments exhibit a characteristic increase in bilirubin monoglucuronides.Harrison 19e pg:2002