A patient needs antibiotic treatment for aificial valve, culture-positive infective enterococcal endocarditis. His medical history includes severe anaphylactic reaction to penicillin G during the past year. The best approach would be treatment with:: (A) Amoxicillin-clavulanic acid, (B) Aztreonam, (C) Cefazolin plus gentamicin, (D) Vancomycin
Answer is D. * Severe allergy to penicillins rule out the use of amoxicillin and cefazolin. * Vancomycin is highly effective against MRSA and enterococcal infections. * Drugs for VRSA and VRE (Vancomycin Resistant Enterococcus faecalis) include linezolid and daptomycin.