Which of the following is an active metabolite of another drug and is available as a separate drug for the treatment of angina?: (A) Isosorbide mononitrate, (B) Isosorbide dinitrate, (C) Nitroglycerine, (D) Propanolol
Answer is A. Isosorbide mononitrate (IMN) is a metabolite of isosorbide dinitrate (IDN) and is also available as a separate drug. IMN undergoes min. first pass metabolism. Nitroglycerine: High first pass metabolism.