Selegiline acts by:: (A) MAO-A inhibition, (B) MAO-B inhibition, (C) COMT inhibition, (D) Dopamine receptor stimulator
Answer is B. (Ref: Katzung 14th ed. pg. 499)* After release of DA in synaptic cleft, it is metabolized either by MAO-b or by COMT (catechol-ortho methyl transferase)* In order to prevent this metabolism following drugs can be given, which will enhance DA availability:# MAO-b inhibitor: Selegiline, Rasagiline, safinamide# COMT inhibitor: Entacapone, TolcaponeDrugs stimulating DA receptor:* Ergot Derivative: Bromocriptine, Cabergoline* Non-Ergot: Pramipexole, Ropinirole, Rotigotine (available as transdermal patch)