A patient is suffering from SLE. On immunofluorescence showed granular deposits at the dermoepidermal junction. What is the constituent in these depostis?: (A) Anticuclear antibodies, (B) Antiepithelial antibodies, (C) Antibodies against collagen, (D) Immune complex deposits
Answer is D. Immunofluoresence in dermatology Disease IgG IgM IgA C3 Flbrin IF pattern Antigen Pemphigus Vulgaris ++ ++ Intercellular- between epidermal cells Network pattern Desmoglein 3 Ig A pemphigus ++ Do Paraneoplastic pemphigus + + + + Do Desmoplakin Bullous pemphigoid ++ ++ Linear deposits along BMZ BP230 BP180 Epidemolysis bullosa aquisita ++ ++ do Collagen 7 Dermatitis Herpatiformis ++ + Granular papillary tip deposits along BMZ Epidermal transglutaminase SLE ++ ++ ++ Granular deposits along BMZ Lichen planus + + + + ++ Ovoid bodies with ragged fibrin band along BMZ Bollous SLE + ++ Linear BMZ deposits Collagen 7 Porphyria ++ + Perivascular and BMZ deposits Amyloid + ++ ++ ++ Globular deposits in tips of apillary dermis