Menke's kinky (Steely) hair disease occurs due to:: (A) Low copper levels, (B) Low zinc levels, (C) Low iron levels, (D) Low fluoride levels
Answer is A. Menke's kinky hair disease- X-linked defect in intestinal absorption of copper. Mutation in ATP7A gene. Low levels of copper and ceruloplasmin. C/F- Progressive cerebral degeneration, growth retardation Sparse brittle hair Scurvy-like bone changes Anemia and neutropenia Failure to thrive Pili toi, trichorrhexis and monilethrix may occur.