Which of the following genes is associated with Xp11 translocation carcinoma variant of renal cell carcinoma?: (A) VHL, (B) TFE3, (C) MET, (D) TSC1
Answer is B. Xp11 translocation Carcinoma: It is a rare genetically distinct subtype of renal cell carcinoma. More common in children. TFE3 gene located at Xp11.2 locus is involved The neoplastic cells consist of clear cytoplasm with a papillary architecture. VHL is associated with clear cell RCC. MET is associated with hereditary papillary RCC. TSC1 is associated with renal angiomyolipoma.