A 33-year-old man is complaining of feeling thirsty all the time and passing more urine than usual. His physical examination is normal, except for a JVP at the sternal angle. His serum sodium is 150 mEq/L, glucose 120 mg/dL, and osmolality 315 mOsm/kg. The urine sodium is 20 mE/L and osmolality 260 mOsm/kg. Which of the following drugs is most likely to cause this disorder?: (A) lithium, (B) cyclophosphamide, (C) barbiturates, (D) nicotine
Answer is A. Nephrogenic diabetes insipidus can be caused by drugs such as lithium, metabolic factors, vascular disease, ureteral obstruction, and genetic factors.