The gaps between segments of DNA on the lagging strand produced by restriction enzymes are rejoined sealed by: (A) DNA Ligases, (B) DNA Helicase, (C) DNA topoisomerase, (D) DNA phosphorylase
Answer is A. RNA primer is excised by DNA polymerase I creating a gap between okazaki fragments which is filled by DNA polymerase I only, and remaining nick is sealed by DNA ligase.