Knudson's two stage hypothesis is for-: (A) Glaucoma, (B) Retinoblastoma, (C) Optic glioma, (D) Meningioma
Answer is B. *Deletion or inactivation of RB gene by two mutations (knudson's two hit hypothesis) results in occurence of retinoblastoma. Ref: Khurana 7th/e p.314.