All are true regarding Prostaglandins except:: (A) LT cause vasoconstriction and decreased vascular permeability, (B) 20 carbon unsaturated fats, (C) Prostacyclin inhibits platelet aggregation, (D) Prostaglandins cause uterine muscle contraction & induce labor
Answer is A. Ans-ARef: Harpers illustrated Biochemistry,28th editionExplanation:Synthesis from arachidonate (See figure on the next page)FUNCTIONSProstacyclin (PGI2)Inhibit platelet aggregationVasodilatationPGF:Uterine muscle contractionInduce laborBronchoconstrictorPGE:BronchodilatorCauses inflammationThromboxaneSynthesis: plateletFunction: platelet aggregationAspirin - Inhibits TXA2 - | Platelet aggregationAspirin is used in the treatment of myocardial infarctionLeukotrienesThe site of synthesis: leukocytes, platelets, macrophagesSlow reacting substance (SRS-A)Leukotrienes-C, D, EFunctions: InflammationVasoconstrictionBronchoconstriction