E-cadherin mutation is seen in metastasis of which type of breast carcinoma: (A) Infiltrative ductal Ca, (B) Lobular Ca, (C) Metaplastic Ca, (D) Medullary Ca
Answer is B. Answer- B. Lobular CaMutation in gene encoding for E-cadherin (CDH-I) is associated with gastric carcinoma and lobular breast carcinoma.Detachment of tumor cells is thefrst step tn metastasis. Normally cells are glued to each other by adhesion moleculesE-cadherin. Normal function of E-cadherin is dependent on catenins that helps in linkage of cytoskeleton to E-cadherin.Down regulation of expression of either E cadherins or catenins results looseining of cells that helps ln metastasis.