A patient with cancer received extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment in that patient during radiotherapy in order to prevent radiation toxicity –: (A) Vincristine, (B) Dactinomycin, (C) Cyclophosphamide, (D) 6 – Mercaptopurine
Answer is B. Actinomycin - D (Dactinomycin) is well is well known radiosensitizer. So its dose should be reduced during radiotherapy to prevent radiation toxicity.