Which of the following antiepileptic agents acts on the GABAergic system to decrease the uptake of GABA into neurons and glial cells?: (A) Vigabatrin, (B) Progabide, (C) Gabapentin, (D) Tiagabine
Answer is D. It potentiates GABA mediated neuronal inhibition by depressing GABA transpoer GAT 1 which removes synaptically released GABA into neurons and glial cells REF: KD TRIPATHI 8TH ED. page 421