Most common cytogenetic abnormality in Multiple myeloma is: (A) Deletion 13q, (B) T, (C) T, (D) T
Answer is A. Multiple myeloma/solitary plasmacytoma: Genotype: Diverse rearrangements involving IgH; 13q deletionsSalient Features: older adults with lytic bone lesions, pathologic fractures, hypercalcemia, and renal failure; moderately aggressive Plasmacytoma: isolated plasma cell masses in bone or soft tissue; indolent Reference: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 13; Disorders of white cells