Risk of breast cancer is highest in: (A) Lobular carcinoma in situ, (B) Proliferative disease without atypia, (C) Proliferative disease with atypia, (D) Atypical ductal hyperplasia
Answer is A. Atypical ductal or lobular hyperplasia are proliferative disease with atypia. Lobular carcinoma in situ carries the highest riskHISTOLOGIC DIAGNOSIS ESTIMATESRRNonproliferative disease1.0Proliferative disease without atypia1.3-1.9Proliferative disease with atypia3.7-4.2Proliferative disease with atypia and strong family history4-9LCIS >7Ref: Sabiston 20e, page: 832