ANCA associated with Wegner's granulomatosis?: (A) cANCA, (B) pANCA, (C) Both, (D) None
Answer is A. Wegener granulomatosis is a necrotising vasculitis characterised by specific triad . Granuloma of the lung or the upper respiratory tract . Vasculitis of small to medium sized vessel most prominently in the lungs and upper respiratory tract . Glomerulonephritis Initiated by cell mediated hypersensitivity response PR3-ANCAs are present in 95 percent of cases and probably drive the subsequent tissue injury Robbins 9 th edition page no. 353