Finnish type of nephrotic syndrome is associated with mutations of which of the following?: (A) Nephrin, (B) Podocin, (C) Alpha actinin, (D) CD2 activated protein
Answer is A. NPHS1 gene mutations = Congenital nephrotic syndrome of the Finnish type, producing a minimal-change disease like glomerulopathy with extensive foot process effacement. NPHS1 is located on chromosome 19q13 and encodes the protein nephrin.