True statement regarding development of drug resistance in MRSA is: (A) Results due to pencillinase enzyme production, (B) Occurs due to change in penicillin -binding proteins, (C) Chromosome mediated, (D) Treated with amoxicillin +clavulanix acid
Answer is B. Ref Katzung 11/e p776 Methicillin resistance occurs due to altered PBPs6, thus no penicillin (infant no beta lactam antibiotic) is useful against Methicillin -resistant Staphylococcus Audrie infections