Which of the following drug toxicity can be seen in Crigler Najjar syndrome?: (A) Tenofovir, (B) Zidovudine, (C) Atazanavir, (D) Nevirapine
Answer is C. Ans. C. Atazanavira. In Crigler-Najjar syndrome there is a deficiency/absence of glucuronyl transferase and hence there can be toxicity of drugs metabolized by glucuronidation.b. Drugs metabolized by glucuronidation with established toxicity in case of Crigler-Najjar syndrome are irinotecan and atazanavir