Which of the following drugs has the highest bactericidal activity against Mycobacterium leprae?: (A) Rifampicin, (B) Clofazimine, (C) Dapsone, (D) Minocycline
Answer is A. Rifampicin has a high bactericidal activity against M. leprae. A single dose of 1500 mg appears to kill 99% of the organisms. Ref: Park 21st edition, page 296.