Specific test for gout is:: (A) Raised serum uric acid level, (B) Raised uric acid in synol fluid of joint, (C) Raised urea level, (D) Raised urease enzyme level
Answer is B. B i.e. Raised uric acid in synol fluid of joint - Gout is a metabolic disorder of purine catabolismQ, and characterized by high level of uric acid in the blood . Uric acid is end product of purine catabolismQ - Pyrimidine nucleotide unlike purine rings can be opened & degraded to highly water soluble structure like, p- alanine, /3? amino isobutyrate, NH3 & CO2. Excess meabolism of pyrimidine therefore does not give rise to clinical manifestationQ Human catabolizes purine (Adenine & Guamine) to uric acid, which is relatively insoluble acid.