Which of the following markers is specific for Gastro intestinal stromal tumors (GIST)?: (A) CD 117, (B) CD 34, (C) CD 23, (D) S-100
Answer is A. CD 117 is most specific marker for Gastrolintestinal stromal tumor, than CD 34. GIST has a universal expression of CD117. It can also be present in fibroblastic and endothelail tumors. Ref: M. Wasif Saif (2010), Chapter "Gastrointestinal Stromal Tumors", In the book, "Gastrointestinal Malignancies", Volume 1, Issue 1, USA, Page 152; Robbin's Basic Pathology, 7th Edition, Page 826; Oncology: An Evidence Based Approach, (2006), Pages 413-14; Sternberg's-Diagnostic Surgical Pathology, 4th Edition, Page 1590