Pathological changes of diabetic nephropathy are all except:: (A) Fibrin caps and capsular drops, (B) Kimmelstein-Wilson lesion, (C) Basement membrane thickening, (D) Focal glomerular sclerosis
Answer is D. Diabetes may cause nodular and diffuse glomerulosclerosis but not focal glomerular sclerosis. Diabetes Mellitus - |ed glucose - non enzymatic glycosylation - Advanced glycation end products - efferent aeriole - |ed filtration injury - Nodular glomerulosclerosis ( most characteristic) : Kimmelstein Wilson lesion - diffused glomerulosclerosis ( |GFR )