A boy is planning to travel by bus. Which of the following drug can be used to prevent motion sickness in this person?: (A) Promethazine, (B) Cetrizine, (C) Loratidine, (D) Fexofenadine
Answer is A. 1st Generation 2nd Generation Cross BBB, cause sedation Do not cross BBB, no sedation Arch - Anticholinergic SLE occur No Ach Useful forMotion SicknessDrug induced parkinsonismMuscular dystoniasAllergy Useful only for allergy Promethazine (max.action)DiphenhydramineDiphenhydrinatePheniramine Chlorpheniramine CyclizineCinnarizine Terfinadine - not used (TDP)Fexofenadine - Terfinadine metaboliteAstemizole - not used (TDP)LoratidineDes loratidineCetrizine, LevocetrizineAzelastine, Olapatadine - Topical