Recurrent Neisseria infections are not predisposed by-: (A) Early complement component deficiency, (B) Late complement component deficiency, (C) Factor D deficiency, (D) Properdin deficiency
Answer is A. Option 1, 2, 3, 4 Inherited or acquired deficiency of C5-8 (late components) components greatly enhances susceptibility to Neisseria bacteremia and other infections. Deficiency of C3 leads to severe recurrent pyogenic sinusitis and respiratory infections. Deficiency of Properdin and factor D (Alternative pathway Deficiency) lead to Neisserial infection and pyogenic infections. Early complement component (C1, C2, C3, C4) deficiency: SLE, glomerulonephritis and pyogenic infections.