Tolcapone is: (A) Ototoxic, (B) Nephrotoxic, (C) Hepatotoxic, (D) All of the above
Answer is C. Tolcapone is a COMT inhibitor used in Parkinson's disease which acts both peripherally & centrally. But it is hepatotoxic.
Entacapone is a peripheral COMT inhibitor which is safe in hepatic insufficiency.