A 20 year old male presents with chronic constipation, head ache and habitus, neuromas of tongue, medullated corneal nerve fibers and nodule of 2*2 cm size in left lobe of thyroid. This patient is a case of:: (A) Sporadic medullary carcinoma of thyroid, (B) Familial medullary carcinoma of thyroid, (C) MEN-2A, (D) MEN-2B
Answer is D. MEN-2A (Sipple Syndrome MEN) MEN-2B (MEN-3) Components Medullary carcinoma thyroid Pheochromocytoma Parathyroid hyperplasia or adenoma Hirschprung&;s Disease Cutaneous lichen amyloidosis Medullary carcinoma thyroid Pheochromocytoma Intestinal ganglioneuromas Mucosal neuromas Megacolon Marfanoid features Defect RET oncogenic (Cysteine codon) Chromosome: 10 RET oncogene (tyrosine kinase domain) Chromosome: 10 Transmission Autosomal dominant Autosomal Dominant Ref: Sabiston 20th edition Pgno: 993,1003