SMAC/DIABLO is a: (A) Anti apoptotic protein, (B) Induces necrosis, (C) Acts both as anti and pro apoptotic protein, (D) Pro-apoptotic protein
Answer is D. Diablo homolog (DIABLO) is a mitochondrial proteinthat in humans is encoded by the DIABLO (direct IAPbinding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, ref Robbins 9/e p 19, and internet