All are true about warfarin except: (A) It inhibits the activation of vitamin K dependent clotting factors, (B) It's half life is 36hrs, (C) It can cross placenta, (D) It's dose is increased in liver disease
Answer is D. Refer Katzung 11/e p595 Warfarin is an oral anticoagulant that acts by inhibiting the gamma carboxylation of glutamate residues in vitamin K dependent clotting factors It has a long half life It readily crosses the placenta Liver disease reduces the synthesis of clotting factors thus increases the effect of warfarin