Amyloidosis is most commonly seen in: (A) Maturity onset DM, (B) Type1DM, (C) Type2DM, (D) Equally seen with all forms of DM
Answer is C. Ref Robbins 8/e p253; 9/e p259 Amyloid replacement of islets is a characteristics finding in individual with long standing type 2 diabetes .it is believed that the islet amyloid protein is directly cytotoxic to isletsanalogous to the role played by amyloid plaques implicated in the pathogenesis of Alzheimer's disease