Wound contraction is primarily mediated by: (A) Smooth muscle cells., (B) Macrophages., (C) Fibroblasts., (D) Myofibroblasts.
Answer is D. Myofibroblasts, cells with features intermediate between fibroblasts and smooth muscle cells, appear in the wound 2 to 3 days after injury. Their active contraction decreases the size of the defect.