Mech of action of bevacizumab: (A) Inhibitor of HER-2/Neu, (B) Inhibitor of VEGF, (C) Inhibitor of c-kit, (D) None of the above
Answer is B. Bevacizumab:- Mech of action:- It is a humanized monoclonal antibody that binds VEGF-A and hinders its access to the VEGF receptor, interrupting angiogenic signalling. Uses:- combined with 5-FU, bevacizumab is used in metastatic colorectal cancer. Added to conventional chemotherapy, it improves survival in metastatic non-small cell lung cancer, breast cancer, clear cell renal carcinoma and glioblastoma. Deafness due to neurofibromatosis can be reversed by growth inhibitory effect of bevacizumab. Ref:- kd tripathi; pg num:-871