All of the following are Glucocoicoid synthesis Inhibitors except?: (A) Metyrapone, (B) Mifepristone, (C) Etomidate, (D) Ketoconazole
Answer is B. Mifepristone is a pharmacological antagonist at the steroid receptor. It is not a Glucocoocoid synthesis. Enzyme Inhibitor. Glucocoicoid synthesis Inhibitors & Glucocoicoids Antagonists: Glucocoocoid synthesis enzyme Inhibitors Blockade of Coisol Action Adrenal Enzyme Inhibitors Ketoconazole Metyrapone Etomidate Adrenolytic agents Mitolane (It also inhibits CYP11A1 thereby reducing steroid synthesis) Mifepristone Ref: Goodman and Gilman 13th edition Pgno: 858