Which of the following test has highest detection rate for Down's syndrome: (A) Maternal serum AFP, (B) Integrated screening, (C) Quadruple marker test, (D) hcG levels
Answer is B. Integrated screening combines first and second trimester tests.
This includes fetal Nuchal Translucency at 11 - 14 weeks + Quadruple markers at 15 - 20 weeks.