Which is the most common second malignancy in survivors of retinoblastoma?: (A) Optic glioma, (B) Osteosarcoma, (C) Thyroid cancer, (D) Nasopharyngeal carcinoma
Answer is B. Osteosacrcomas are the most common second malignancy in survivors of retinoblastoma. Ref: Cancer in Children and Adolescents By William Larkin Carroll, Page 384; Manual of Pediatric Hematology and Oncology By Philip Lanzkowsky, 5th Edition, Page 947