A 24 yr-old female has flaccid bullae over the skin and oral erosions. Histopathology shows intraepidermal blister with acantholytic cells. Diagnosis is:: (A) Pemphigoid, (B) Erythema multiforme, (C) Pemphigus vulgaris, (D) Dermatitis herpetiformis
Answer is C. The features of intaepidermal acantholytic blisters coupled with flacid bullae over skin and oral erosions points towards P. vulgaris. The other 3 diseases do now show intraepidermal blistering. They are devoid of mucosal involement. Erythema Multiforme: Target lesion seen on distal extremeties. If mucosa involved it is called as Epidermal Multiforme Major Dermatitis herpetiformis: Extremely pruritic vesicopapules over extensors Pemphigoid: Tense bullae