Increased ratio of insulin to glucagon causes:: (A) Decreased levels of cyclic AMP, (B) Decreased levels of lipoprotein lipase, (C) Decreased amino acid synthesis, (D) Enhanced lipolysis in adipose tissue
Answer is A. Glucagon acts via increase in intracellular cAMP. So, in high insulin glucagon ratio, cAMP level in the cell decreases. Insulin causes activation of lipoprotein lipase and inhibition of hormone­-sensitive lipase. Because of this, there is increased fatty acids synthesis in adipose tissue. Insulin also increases amino acid uptake and protein synthesis in muscles. Normal insulin­ glucagon molar ratio on a balanced diet is approximately 2.3.