What is the mode of inheritance of Hereditary spherocytosis?: (A) Autosomal dominant, (B) Autosomal recessive, (C) X-linked recessive, (D) X-linked dominant
Answer is A. - Hereditary spherocytosis is inherited in an Autosomal dominant pattern. - Results from instability of spectrin & ankyrin which are major skeletal membrane proteins. - Degree of protein deficiency correlates with degree of hemolysis. - Demonstrated by Increase in osmotic fragility after 24hrs incubation of blood at 37oC.