VWF factor deficiency causes:: (A) | Platelet adhesion, (B) | Factor VIII in plasma, (C) Defective platelet adhesion, (D) All of the above
Answer is D. Deficiency of Von willebrand factor (VWF -promote platelet adherence and activation) causes | Platelet adhesion ( |BT ) | Intrinsic pathway activity ( | aPTT) | Factor VIII in plasma C/F Mucosal bleeding - Petechiae /purpura /epistaxis / melena Tissue bleeding Rx - Desmopressin for mild form - Cryoprecipitate for severe form