What is the ratio of Kappa and lambda free light chains normally: (A) 7:03, (B) 6:04, (C) 4:06, (D) 3:07
Answer is C. In a healthy individual, the total kappa tolambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm. Ref Robbins 9/e p102