The protein in the GBM responsible for charge dependent filtration is: (A) Albumin, (B) Collagen type IV, (C) Fibronectin, (D) Proteoglycan
Answer is D. Glomerular basement membrane contains: a. Collagen type IV b. Laminin c. Polyanionic proteoglycans (responsible of charge-dependent filtration) d. Entactin e. Fibronectin f. Sialoglycoprotein coating on endothelial and visceral epithelial cells. Ref: ROBBINS BASIC PATHOLOGY 10th ed Pg no: 551