Which of the following is not a feature of Papillary carcinoma of thyroid?: (A) Rearrangement of RET gene, (B) Rearrangement of NTRK1 gene, (C) Mutation of BRAF gene, (D) Mutation of RAS gene
Answer is D. Most papillary carcinomas have gain-of-function mutations or rearrangements involving: RET gene NTRK1 receptor tyrosine kinases Serine/threonine kinase BRAF, which is component of MAPK pathway. RAS mutations are seen in follicular carcinoma of thyroid.