In a case of ectopic pregnancy, medical treatment is contraindicated if:: (A) Sac size is 3.0 cm, (B) Serum HCG levels > 1500 miu / ml, (C) Significant hemoperitoneum is present, (D) Absent fetal activity
Answer is C. Criteria for medical treatment 
1) Ectopic mass <3.5cm – the presence of fetal cardiac activity is a contra-indication to medical treatment
2) No fetal cardiac activity
3) Initial hCG <3000iu/l
4) The patient must be hemodynamically stable, with no signs or symptoms of active bleeding or hemoperitoneum.
5) She should not have any contraindications to the use of methotrexate.