Most significant complication of polycythemia rubra vera is:: (A) Transformation into leukemia, (B) Secondary bone marrow failure, (C) Hypersplenism, (D) Thrombosis
Answer is D. Polycythemia rubra vera It is an indolent disorder Thrombosis is the most significant complication Maintenance of the hemoglobin level at 140 g/L (14 g/dL; hematocrit Phlebotomy :serves to help this aim Ref: Harrison, E-18,P-903