In Alloimmune thrombocytopenia antigen against which antibody is found?: (A) HPA 1a, (B) HPA 1b, (C) HPA 2a, (D) HPA 2b
Answer is A. Neonatal alloimmune thrombocytopenic purpura (NATP): - Caused by development of maternal antibodies against antigens present on fetal platelets that are shared from father & recognized as foreign by maternal immune system. - The most common cause is incompatibility for the platelet alloantigen HPA-1a.