Conjugated bilirubin is increased in ?: (A) Rotor syndrome, (B) Gilbe's syndrome, (C) Crigler Najjar syndrome 1, (D) Crigler Najjar syndrome 2
Answer is A. crigler najjar syndrome-1:defect in conjugation,so unconjugated bilirubin level increases to more than 20mg/dl crigler najjar syndrome-ll:second stage of conjugation is defective Gilbe&;ssyndrome:defect in the uptake of bilirubin by liver. Rotor&;s syndrome:bilirubin excretion is defective, but there is no staining of liver. TEXTBOOK OF BIOCHEMISTRY,D.M.VASUDEVAN,PG NO:251,252,6th edition