Which of the following is an example for Transplacental carcinogenesis?: (A) Vaginal Ca, (B) Pancreatic Ca, (C) Colon Ca, (D) Breast cancer
Answer is A. Ref: Shaw's Textbook of Gynaecology, 15th ed. pg :52 Explanation:Transplacental carcinogenesis is a series of genotypic or phenotypic changes in the cells of a fetus due to in utero exposure to carcinogens.Adenocarcinoma (clear cell carcinoma) was seen in the vagina in children whose mothers took Diethylstilbesterol for threatened abortion.