A 65-year-old male diagnosed by biopsy a case of squamous cell carcinoma of lung, has very high serum calcium levels. Probable cause is?: (A) Parathyroid hormone, (B) Parathyroid hormone-related peptide, (C) Calcitonin, (D) Calcitonin-related peptide
Answer is B. Paraneoplastic syndromes The most impoant mechanism is the synthesis of a parathyroid hormone-related protein (PTHrP) by tumor cells (Commonly in Squamous cell carcinoma) leading to Hypercalcaemia.