Factors responsible for cardiovascular effects of non depolarizing neuromuscular blockers:-: (A) Histamine release, (B) Effects mediated by autonomic nicotinic cholinergic receptors, (C) Pancuronium produced a profound vagolytic response, (D) All of the above
Answer is D. All benzylisoquinoline except cisatracurium causes histamine release - | BP | HR - CVS Effects mediated by autonomic nicotinic Cholinergic receptor ex. Pancuronium (vagal blockade) | BP | HR Pancuronium produced a profound vagolytic response characterized by tachycardia, reduction in hea rate variability and baroreflex sensitivity .