Which of the following malformation in a newborn is specific for maternal insulin dependent diabetes mellitus ?: (A) Transposition of great arteries, (B) Caudal regression, (C) Holoprosencephaly, (D) Meningmyelocele
Answer is B. The fetal malformations seen in Caudal regression syndrome are the most typical seen in cases of maternal diabetes'.- Early detection of caudal regression syndrome, D. Subtil et al.
Caudal regression :

Caudal regression syndrome (CRS) is a rare malfonnative syndrome seen mainly in cases of maternal diabetes with poor metabolic control.
This syndrome associates vertebral agenesis of variable level with genito-urinary and digestive malformations. These abnormalities are related to the impaired development of the mid-posterior axis mesoderm