Glyceryl trinitrate is given by sublingual because of: (A) Sho t1/2 in plasma, (B) High hepatic first pass metabolism, (C) High bioavailability by oral route, (D) Extensive protein binding
Answer is B. Refer kDT 6/e p 7 Main advantage of Sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation