Which is true regarding IL-1?: (A) Mainly derived from neutrophils, (B) Produces necrosis of tumor cells, (C) Increases expression of MHC coded proteins, (D) Upregulates adhesion molecules
Answer is D. Produced by tissue macrophages, monocytes, fibroblasts and dendritic cells and also expressed by B cells, lymphocytes, NK cells and epithelial cells Increases the expression of adhesion factors on endothelial cells to enable transmigration Causes fever, hyperalgesia, vasodilation and hypotension