Metaplasia is thought to be caused in most cases by:-: (A) Genetic mutation, (B) Oncogenic virus, (C) Chronic irritation, (D) Immunologic reaction
Answer is C. Chronic irritation Metaplasia is commonly seen in the epithelial surfaces of the bronchial tree secondary to chronic irritation of cigarette smoke. Metaplasia may also be seen in areas of long-standing, chronic infections.