Mechanism of action of aminophylline in bronchial asthma:: (A) Decreasing phosphodiesterase activity, (B) Direct action on smooth muscles, (C) Releasing catecholamines, (D) Stabilizing membrane of mast cells
Answer is A. Aminophylline and other methylxanthines act byInhibiting phosphodiesterase enzyme causing - cAMPBlocking adenosine receptorsReleasing Ca2+ from sarcoplasmic reticulum in cardiac and skeletal muscles.Use-Asthma, COPD, chronic bronchitis