Which of the following increases the susceptability to corornary aery disease?: (A) Type V hyperlipoprotenemia, (B) Von willibrand disease, (C) Nephrotic syndrome, (D) Systemic lupus erythematosus
Answer is C. Nephrotic syndrome is a clinical complex characterized by protenuria,hypoalbunemia,edema and hyperlipedemia. A hypercoaguble state frequently accompanied by severe nephrotic syndrome due to urinary loss of AT-III reduced serum levels of protein C and S hyper fibrogenemia and enhanced platelet aggregation. Due to increased coagulation state,predisposing to CAD is present in patients with nephrotic syndrome (ref Harrisons 17th/272)