Most common tumor suppressor gene involved in cancer genesis is?: (A) Rb, (B) p53, (C) p16, (D) p73
Answer is B. Ans. is 'b' i.e., p53 * p53 is a tumor suppressor gene. p53 gene is located on chromosome 17. p53 acts as molecular policeman that prevents the propagation of genetically damage cell.* p-53 is the most common target for genetic alteration in human tumors; A little over 50% of human tumors contain mutation in this gene.Note - Amongst oncogene RAS is involved most commonly