Which of the following causes haemolytic anemia -: (A) Hereditary spherocytosis, (B) Infection, (C) Iron deficiency, (D) Sic kle cell anemia
Answer is A. In heriditary spherocytosis , as the age of RBC increases they undergo loss of membrane fragments and acheive spherical shape (spherocyte) . spherocytes are rigid inflexible and less deformable hence they get trapped in spleen to premature destruction resulting in hemolytic anemia. Referance:Exam preparatory manual for UGs -Pathology By Ramdas Nayak Page no:264 Ref Robbins 9/e pg 412