Which of the following strategies for administering magnesium sulfate for eclampsia prophylaxis should be used in the  setting of an elevated serum creatinine: (A) Give 3g loading dose followed by 2g/hr infusion, (B) Give 3g loading dose, check magnesium level, and then titrate infusion rate, (C) Give no loading dose and start infusion at 2g/hr, (D) None of the above
Answer is D. In case of severe renal dysfunction , only loading dose of magnesium sulfate is required to produce steady state therapeutic level.