NSAID proposed to be acting inhibition of COX-3 is:: (A) Nimesulide, (B) Paracetamol, (C) Ketorolac, (D) Rofecoxib
Answer is B. - Paracetamol or acetaminophen has antipyretic and analgesic activities but it lacks anti-inflammatory action. - It is presumed to become inactive by peroxides generated at the site of inflammation therefore, lacks anti- inflammatory action. - Some theories suggest that PCM acts on COX-3 receptors in brain. - A metabolite of paracetamol is assumed to work through vanilloid receptor TRPV-1.