Activated protein C inhibit clotting mechanism by inactivating which of the following clotting factors:: (A) Factor IIIa and Factor VIIIa, (B) Factor VIIIa and Factor IXa, (C) Factor Va and Factor VIIIa, (D) Factor Va and Factor VIIa
Answer is C. Protein-C is a vitamin K-dependent protease that requires a cofactor (Protein S). Activated Protein C/protein S forms a complex which is a potent inhibitor of coagulation factors Va and Factor VIIIa. Protein C acts as a Tissue factor pathway inhibitor (TFPI)