H a t year old patient on Oxygen therapy has developed digital toxicity. The plasma peacocks in level is 4ng/ml. Renal function is normal and the plasma half life for digoxin in this patient is 1.6 days. How long should give with hold digoxin in order to reach a safer yet probably therapeutic level of 1ng/ml: (A) 1.6days, (B) 2.4days, (C) 3.2days, (D) 4.8days
Answer is C. Ref-Katzung 10/e p48 WeWwant to decrease a plama concentration of digoxin from 1ng/ml.it will take two half lives.thus time required is 2x1.6=3.2days