Superantigens true is -: (A) They bind to the left of the MHC, (B) Needs to processed before presentation, (C) They are presented by APC'S to T cells, (D) Directly attached to lateral aspect of TCR b chain
Answer is D. Superantigens are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. Superantigens bind first to the MHC Class II and then coordinate to the variable alpha or beta chain of T-cell Receptors . Reff: Ananthanarayan & Panikers textbook of microbiology 9th edition pg:90