All of the following represent disorders or protein misfolding, except: (A) Alzheimer's disease, (B) Tuberculosis, (C) Cystic fibrosis, (D) Creutzfeldt-Jakob disease
Answer is B. A normal gene makes the normal Prp protein .when gene is mutataed there will be protein misfolding. in Alzhener&;s disease, there is beta amyloid protein formation . this fuher forms plaque . this causes dementia , hallucination etc. cystic fibrosis is caused by abnormal protein CFTR. Creutzfeldt disease is caused due to prions. tuberculosis is an infectious disease and does not cause protein misfoldingRef: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 728 & 606