Sickle cell disease is present with which mutation:: (A) Cross-linked defect, (B) Base pair defect, (C) Mismatch defect, (D) Base pair substitution
Answer is D. Ans. (d) Base pair substitutionRef: Harper's Biochemistry, 30th ed. pg. 416-17A partial missense mutation (type of base pair substitution) glutamic acid, the normal amino acid in position 6 of the b chain, has been replaced by valine.