The following have defect in DNA repair mechanism except for:: (A) Xeroderma Pigmentosa, (B) Fanconi anemia, (C) Huntington's disease, (D) Ataxia-telangectasia
Answer is C. Huntington disease (HD) Autosomal dominant disease It is a prototypes of the polyglutamine trinucleotide repeat expansion diseases. The gene for it is located on chromosome 4p16.3, encodes a 348 kD protein known as huntingtin. Xeroderma Pigmentosum Inherited disorder of DNA repair Diseases with Defects in DNA Repair by Homologous Recombination: Bloom syndrome Ataxia-telangiectasia Fanconi anemia