Not true regarding serotonin syndrome is:: (A) It is predictable and not idiosyncratic, (B) SSRIs and MAOIs cause it, (C) IV dantrolene is the treatment of choice, (D) Hypeension, hypehermia and hyperrelfexia are the signs
Answer is C. Dantrolene is not the treatment of choice, though it is at times used to control the hypehermia. Serotonin Syndrome: It is predictable not idiosyncratic Neurotransmitter Basis Serotonin (5-HT) increase Causative Agents SSRI + MAOI (e.g., phenelzine) SSRI + serotonergic pain medication (e.g., meperidine, tramadol) SSRI + cough suppressant (e.g., dextromethorphan) Symptoms 1. Fever2. Autonomic instability3. Diarrhea4. Myoclonus5. Mental status changes6. Hyperkinesia7. Rapid onset Lab Findings No change in CPK or liver enzymes Management Stop agentSuppoive treatment and antiserotonin agent (e.g., cyproheptadine)