The following statement is false regarding Grave's disease: (A) Hyperophy/hyperplasia is due to TSH-RAbs, (B) Cardiac failure is common, (C) Goiter is diffuse and vascular, (D) Remissions and exacerbations are not infrequent
Answer is B. Grave&;s Disease (Diffuse Toxic Goiter)M/C cause of hypehyroidism, caused by stimulatory autoantibodies to TSH-RMore common in females with peak incidence between 40-60 yrsClinical FeaturesHypehyroid symptoms- heat intolerance, increased sweating and thirst, weight loss despite adequate caloric intake.Symptoms of adrenergic stimulation- palpitations, nervousness, fatigue, emotional lability, hyperkinesis and tremorOlder patients present with CVS complications (CVF and CHF)In Grave's disease- Cardiac toxicity is less and CNS toxicity is more. In secondary thyrotoxicosis cardiac toxicity is more common.(Refer: Schwaz's Principles of surgery, 9th edition, pg no: 1353-1354)