Wire loop thickening of glomerular basement membrane is seen in -: (A) Systemic lupus erythematosus (SLE), (B) Non Insulin Dependent Diabetes Mellitus, (C) Rapidly progressive glomerulonephritis, (D) Malignant hypeension
Answer is A. Ans. is 'a' i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis.