The most clinically significant skin eruption associated with M. pneumoniae infection is:: (A) Erythema multiforme major, (B) Bullous eruptions, (C) Toxic epidermal necrosis, (D) Pyostomatitis vegetans
Answer is A. Erythema multiforme major (Stevens-Johnson syndrome) is the most clinically significant skin eruption associated with M. pneumoniae infection. Ref:Harrisons Principles of Internal Medicine, 18th Edition, Page 1418