Conjugated hyperbilirubinemia: (A) Dubin johnson syndrome, (B) Criggler naj jar syndrome, (C) Breast milk jandice, (D) Gilbe syndrome
Answer is A. Ans. is 'a' i.e., Dubin johnson syndrome Breast milk jaundice - Decrease bilirubin uptake across hepathocyte membrane. Entero-hepatic recirculation. Leads to indirect hyperbilirubinemia. Crigler naj jar & Gilbe syndrome (deficiency of glucuronyl transferase) <Type I - Complete deficiency Type II - Paial deficiency Decrease conjugation leads to Indirect hyperbilirubinemia. Defect in hepatocyte secretion of conjugated bilirubin. Leads to direct hyperbilirubinemia