In which of the following carcinomas of breast, loss of E-cadherin plays a vital role in pathogenesis?: (A) Paget's disease, (B) Ductal carcinoma, (C) Lobular carcinoma, (D) Medullary carcinoma
Answer is C. The main pathogenesis underlying Lobular carcinoma is accquired loss of the tumor suppressive adhesion protein E-cadherin, also called as CDH-1.