Which one of the following drugs does not have active metabolite: (A) Diazepam, (B) Lisinopril, (C) Propanolol, (D) Allopurinol
Answer is B. Lisinopril - It is a lysine derivative of enalaprilat, doesn't require hydrolysis to become active ACE inhibitor. It's oral absorption is slow and incomplete, but unaffected by food.