Alpo&;s syndrome is due to defective-: (A) Collagen, (B) Elastin, (C) Fibrillin, (D) Proteoglycan
Answer is A. Out of various hereditary nephritis, Alpo's syndrome is relatively more common and has been extensively studied. This is an X-linked dominant disorder having a mutation in a-5 chain of type IV collagen located on X-chromosome. Ref: Harsh Mohans textbook of pathology 6th edition page 678