Loading drug of dose primarily depends on: (A) Volume of distribution, (B) Clearance, (C) Rate of administration, (D) Half life
Answer is A. Loading dose; This is a single or few quickly repeated doses given in the beginning to attain target concentration rapidly.
Loading dose = Target Cp * V /F
Cp - concentration, V - volume of distribution, F - oral bioavailability
Thus, the loading dose is governed only by V and not by Clearance or t1/2