In-situ DNA nick end labeling can quantitate: (A) Fraction of cells in apoptotic pathways, (B) Fraction of cells in S phase, (C) p53 gene product, (D) bcr/abl gene
Answer is A. In situ DNA nick end – labeling is an in-situ method for detecting areas of DNA which are nicked during apoptosis.
Terminal deoxynucleotidyl transferase mediated dUTP–biotin nick end labeling (TUNEL) is a method for detecting apoptotic cells that exhibit DNA fragmentation.