Primary abnormality in sequence of events leading to DIC is-: (A) Fibrin deposits in multiple sites, (B) Uncontrolled thrombin generation, (C) Abnormal adhesion and consumption ofplatelets, (D) Destruction of red cells
Answer is B. The sequence of events in DIC are: activation of coagulation, thrombotic phase,consumption phase,secondary fibrinolysis. Massive tissue injury ,infections ,widespread endothelial damage stimulates widespread activation of coagulation pathway bye release of tissue factor & uncontrolled thrombin generation is the primary pathway.Reference:Harsh mohan textbook of pathology sixth edition pg no 337