MgSO4 have no role in prevention of: (A) Seizures in severe pre-eclampsia, (B) RDS in premature baby, (C) Recurrent seizures in eclampsia, (D) Neuroprotection
Answer is B. Magnesium sulphate: - Mechanism of action:- * Reduced presynaptic release of the neurotransmitter glutamate * Blockade of glutaminergic n-methyl-d-aspaate (nmda) receptor * Potentiation of adenosine action * Improved calcium buffering by mitochondria * Blockage of calcium entry voltage-gated channels Used for: - * Severe preeclampsia * Recurrent eclamptic seizures * Neuroprotection Must check: - * Urine output * Respiratory rate * Patellar reflexes Ref:- Williams obstetrics 25th Edition; Pg num:- 38/68