Tobacco induced squamous cell carcinoma doesn't involve mutation in: (A) P53, (B) P16, (C) P63, (D) NOTCH 1
Answer is B. Tobacco carcinogens induced cancers involve a mutation in the P53 pathway as well as proteins responsible for squamous differentiation . Conversely HPV associated squamous cell carcinomas overexpress P16.Reference: Robbins; 9th edition; Volume II; Oropharyngeal squamous cell carcinoma molecular biology; Page no: 733