Barbiturates act on which step of mitochondrial respiratory chain:: (A) Complex I to Co-enzyme Q, (B) Coenzyme Q to Complex III, (C) Complex II to Coenzyme Q, (D) Cytochrome C to Complex IV
Answer is A. option a : Barbiturates such as amobarbital inhibit electron transpo Complex I by blocking the transfer from complex I to Coenzyme Complexes Inhibitors of ETC Complex I (NADH-CoQ reductase/NADH dehydrogenase) Rotenone, Phenobarbitone, Amobarbital, Piericidin A Complex II (Succinate CoQ reductase) Malonate (3C) Carboxin (Fungicide) TTFA (Trienoyl Tri Fluoro Acetone) Complex III (Cyt c reductase) Phenoformin Antimycin A BAL (British Anti Lewisite) or Dimercaprol) Complex IV (Cyt c oxidase) CO Cyanide (CN), H2S, Sodium Azide Uncouplers of ETC: Dinitrophenol, Thermogenin ADP to ATP conversion is inhibited by: Oligomycin ADP to ATP transfer is inhibited by: Atractyloside