Which of the following is the characteristic of a highly ionized drug?: (A) High protein binding, (B) Can cross placental barrier easily, (C) Rapidly absorbed from stomach, (D) Excreted mostly by the kidneys
Answer is D. A highly ionized drug is not reabsorbed by the tubules and is easily excreted by the kidneys because it is lipid insoluble. Ref: Dr J G Buch, (2010) Chapter 3, "Pharmacokinetics", "Clinically oriented pharmacology", Newdelhi, Page 13