Loading dose depends on the following factors except:: (A) Drug concentration to be achieved, (B) Volume of distribution, (C) Clearance of the drug, (D) Bioavailability of drug
Answer is C. * Loading dose= volume of distribution x target plasma concentration/fractional bioavailability. * Maintenance dose= clearance x target plasma concentration/fractional bioavailability. * So the answer is clearance as it determines maintenance dose instead of loading dose.