A one year old child having leukocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involve –: (A) Enucleation, (B) Chemotherapy followed by local dyes, (C) Direct Laser ablation using photodynamic cryotherapy, (D) Scleral radiotherapy followed by chemotherapy.
Answer is A. Tumor involving less than half of the globe → Multimodal therapy (Chemoreduction followed by local destruction).
Tumor involving half or more of the globe → Enucleation.