True about Congenital Rubella syndrome is: (A) It will become a chronic infection, (B) Virus can be isolated only upto 6months after bih, (C) Triad of CRS are cataract, cardiac defects, cerebral palsy, (D) Infection is most serious after five months of pregnancy
Answer is A. * Rubella infection gets transmitted by veical transmission and bih defects is more common when acquired during first trimester of pregnancy. * Bih defects are uncommon when infection is acquired after 20 weeks of gestation. * Congenital Rubella syndrome leads to cardiac defects, cataract and deafness; (Classical triad). Other manifestations are hepatosplenomegaly, thrombocytopenic purpura, myocarditis and bone lesions. * Intrauterine infection of Rubella is associated with chronic persistence of disease. * Viral detection can be done in all fluids and it is excreted upto 12-18 months of age. Ref:- Jawetz TB of medical microbiology 27th edition; pg num:- 597