True about Azathioprine is?: (A) It has more anti tumor effect than immunosuppressant effect, (B) It is not a prodrug, (C) It selectively affects differentiation of T cells, (D) It is a pyramidine antimetabolite
Answer is C. ANSWER: (C) It selectively affects differentiation of T cellsREF: KDT 6th ed p. 840AZATHIOPRINEPurine antimetaboliteMore marked immunosuppressant effect than antitumour effectIt's a prodrug and converted to more active 6-mercaptopurineSelectively inhibits T cell differentiation and function of T cellsMost important application - graft rejections/e - bone marrow suppression