Most common site of cholangiocarcinoma: (A) Distal biliary tract, (B) Hilum, (C) Intrahepatic duct, (D) Multifocal
Answer is B. Cholangiocarcinoma Tumors arising from bile duct epithelium. Most common type is adenocarcinoma Differentiated by anatomic site of origin: Intrahepatic (10%), Hilar (65%), and distal (25%) MC gene mutation is K-ras >p16(KRAP-16) Ref: Sabiston 20th edition Pgno :1514-1518