Thiazide cause-: (A) Metabolic alkalosis, (B) Metabolic acidosis, (C) Respiratory alkalosis, (D) Respiratory acidosis
Answer is A. Ans. is 'a' i.e., Metabolic alkalosiso By inhibiting salt reabsorption in TAL, loop diuretics increase deliver)' to the collecting duct. Increased delivery-leads to increased secretion of K- and H+ by the duct, causing hypokalemic metabolic alkalosis. This toxicity is the function of the magnitude of the dieresis and can be reversed by K+ replacement and correction of hypovolemia,o Carbonic anhydrase inhibitors decrease the excretion of H+ and increase the excretion of HC03-in the urine. This results in metabolic acidosis and urinary' alkalosis.Urinary Electrolytes GroupNaCINaHCO3K+Body pHCarbonic Anhydrase Inhibitors+++++-Loop agents++++0++Thiazides+++++Loop agents plus Thiazides+++++++++K+ - sparing agents+(+)--