Which of the drug Does not have active metabolite: (A) Diazepam, (B) Propanonol, (C) Allupurinol, (D) Lisnopril
Answer is D. (Ref KDT 6e p485). Captopril and lisinopril are ACE inhibitors that are not prodrugs. Diazepam produce many active metabolites like.oxazepam. Propranolol can produce 4-hydroxypropanolol .which has b-antagonist activity. Allopurinol gives rise to oxypurinol which can inhibit xanthine oxidase.