Vigabatrin acts through -: (A) decreasing GABA uptake at synaptic cleft, (B) Increasing GABA uptake at synaptic cleft, (C) GABA transaminase inhibitor, (D) GABA transacetylase inhibitor
Answer is C. Ans. is 'c' i.e., GABA transaminase inhibitor Vigabatrin (g vinyl GABA)* It is a newer anti - convulsant which is an inhibitor of enzyme GABA transaminase; it thus increases GABA concentration at synapse.* It is mainly used in patients with refractory epilepsy visual field defects and behavioural changes restricts its use.