Which of the following organelles plays a pivotal role in Apoptosis:: (A) Mitochondria, (B) Endoplasmic Reticulum, (C) Nucleus, (D) Golgi Apparatus
Answer is A. Initiation of apoptosis occurs through two different pathways, intrinsic mitochondria pathway and extrinsic death receptor mediated pathway. Mitochondria plays active role in apoptosis. Ref: Tanley L. Robbins, Ramzi S. Cotran, (2012) , Chapter 1, "Cell Injury", In the book, "Pocket Companion to Robbins and Cotran Pathologic Basis of Disease", 8th Edition, USA, Page 27; Robbin's Basic Pathology, 7th Edition, Pages 28, 29; Essential of Apoptosis (2003), Page 245