All are true about the Etiology of primary myelofibrosis , EXCEPT:: (A) JAK2 mutation is seen in 50 % cases, (B) Overproduction of transforming growth factor, (C) Overproduction of osteoprotegerin, (D) Mutations in the thrombopoietin receptor Mpl occur in 50%
Answer is D. Primary myelofibrosis ,Etiological features. The etiology is unknown. JAK2 V617F is present in approximately 50% of patients Mutations in the thrombopoietin receptor Mpl occur in about 5%. Fibrosis is associated with overproduction of transforming growth factor and tissue inhibitors of metalloproteinases Osteosclerosis is associated with overproduction of osteoprotegerin. Ref: Harrison, E-18,P-906.