True statement about cyclooxygenase -2 is:: (A) It is not inhibited by indomethacin, (B) It is inducible, (C) It generates cytoprotective prostaglandins in gastric mucosa, (D) It is found only in fetal tissues
Answer is B. COX-1 is a house-keeping enzyme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a nonselective inhibitor of both isoforms of COX.