Submicroscopic deletions of any size can be detected by:: (A) Multiplex ligation-Dependent probe amplification (MLPA), (B) Southern blotting, (C) Cytogenomic array technology, (D) Chromosome painting
Answer is A. a. Multiplex ligation-Dependent probe amplification(Ref: Nelson's 20/e p 605, Ghai 8/e p 6045)Multiplex Ligation-Dependent Probe Amplification (MLPA): It is a technique which mixes DNA hybridization, ligation, & PCR amplification to detect deletions & duplications of any size, including anomalies that are too large to be detected by PCR and too small to be identified by FISH.