Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA-2 mutations :: (A) Use of oral contraceptive pills, (B) Screening with transvaginal ultrasound, (C) Sreening with CA -125, (D) Prophylactic oophorectomy
Answer is D. - women with strong family history of BRCA 1 and BRCA 2 mutations have high chance of developing ovarian cancer. - they are advised to undergo genetic testing for mutations of these genes. - in such women who are positive for such genes and have completed their family is advised to have prophylactic bilateral salpingo oophorectomy after 35 and before 40. Reference: Textbook of gynaecology Sheila balakrishnan, 2nd edition, pg no:276