A diabetic patient with autonomic neuropathy presents with dizziness, hypotension during early morning when waking from bed. Drug of choice for this condition?: (A) Dopamine / Dobutamine, (B) Isoproterenol, (C) Clonidine, (D) Midodrine
Answer is D. DOC for Postural hypeension SBP decrease > 20 mmHg DBP decrease >10 mmHg On Supine - Standing 3 minutes [?]1 agonist MOA - VC Clonidine - (a2 agonist) Isoproterenol - nonselective b- adrenoreceptor Isoproterenol - nonselective b- adrenoreceptor Dobutamine - b1 adrenoreceptor