Gigantism is due to:: (A) Increased secretion of coisol, (B) Decreased secretion of coisol, (C) Increased secretion of growth hormone, (D) Decreased secretion of growth hormone
Answer is C. - Excess GH results in: overgrowth / gigantism during childhood with open epiphysis * After fusion of epiphysis - ACROMEGALY - Features of Acromegaly: Coarse facies large tongue Prognathism(protruded lower jaw) thick skin broad nose headache & visual field defects - Best screening test - IGF 1 levels - TREATMENT: Somatostatin analogues (Octreotide) GH Receptor antagonist (Pegvisomant)