Investigation of choice in hirschsprung disease is -: (A) Biopsy, (B) Manometry, (C) Colonoscopy, (D) Barium enema
Answer is A. Ans. is 'a' i.e., Biopsy * The investigation of choice for diagnosis requires an adequate rectal biopsy and an experienced pathologist.* A contrast enema may show the narrow aganglionic segment, a cone and the dilated proximal bowel.