Which of the following is not a feature of autoimmune hepatitis?: (A) Anti-SMA antibodies, (B) Anti-LKM1 anitbodies, (C) Anti-mitochondrial antibodies, (D) Anti-Sm antigen antibodies
Answer is D. Anti-Sm antigen antibodies are found in SLE. Autoantibodies found in Type 1 autoimmune hepatitis: Antinuclear antibodies (ANAs) Anti-smooth muscle actin (SMA) antibodies Antibodies against soluble liver antigen/liver-pancreas antigen (SLA/LPA) Anti-mitochondrial antibodies (AMA, more typical of primary biliary cholangitis) Autoantibodies found in Type 2 autoimmune hepatitis: Anti-liver kidney microsome-1 (LKM-1) antibodies, which are directed against CYP2D6 Anti-liver cytosol-1 (ACL-1) antibodies