Which of the following statements about Pseudohypoprathyroidismistrue-: (A) Caused by 'Gain of!ftmction' inherited mutation in Gsa subunit, (B) Decreased formation of cyclic GMP is observed, (C) Decreased formation of Inositol triphosphate is observed, (D) Decreased formation of c-AMP is observed
Answer is D. decreased urinary cyclic AMP responses to PTH , presumably with a post -GS alpha defect in adenyl cyclase stimulation ( Harrison 17 pg 2394)