Which of the following antibodies is most frequently seen in Antiphospholipid Syndrome ? -: (A) Beta 2 microglobulin antibody, (B) Anti-nuclear antibody, (C) Anti-centromere antibody, (D) Anti- beta 2 glycoprotein antibody
Answer is D. Antiphospholipid antibody syndrome has clinical manifestations including recurrent thrombosis, repeated miscarriages, cardiac valve vegetations and thrombocytopenia. Suspected Ab target include Beta 2 Glycoprotein 1, a plasma protein that associates with the surfaces of endothelial cells and trophoblasts. Anti nuclear antibody and beta 2microglobulin Ab seen in SLE. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition -9;volume 1.page no. 124