Gastric carcinoma is associated with all of the following, except?: (A) Inactivation of p53, (B) Over expression of C-erb, (C) Over expression of C-met, (D) Activation of RAS
Answer is B. Mutated p53 isoforms can generate an autoimmune response. Serum anti-p53 antibodies can serve as a diagnostic and prognostic marker in gastric cancer patients.Amplification of the c-met gene has been demonstrated in scirrhous-type gastric cancers. c-met is overexpressed or amplified in advanced gastric cancers of both the well-differentiated and poorly differentiated types.Ras activation is associated with the development of gastric cancer, but it is rare.