Which of the following drugs is Topoisomerase 1 inhibits: (A) Doxorubicin, (B) Irinotecan, (C) Etopside, (D) Vincristine
Answer is B. Refer KDT 6/e p 825, Camptothecin derivatives like topotecan and irinotecan act by inhibiting Topoisomerase -1whereras epipodophylotoxins and anthracycline act by inhibiting Topoisomerase -2