Biotin may be used for treatment of which of the following conditions?: (A) Maple syrup urine disease, (B) Methylmalonic acidemia, (C) Phenylketonuria, (D) Multiple carboxylase deficiency
Answer is D. Biotin is a cofactor for carboxylase, so it can be used in the treatment of multiple carboxylase deficiency. Maple syrup urine disease- Thiamine Methylmalonic acidemia- Vitamin B12, L- carnitine, Metronidazole Phenylketonuria- Tetrahydrobiopterin