Red man syndrome is due to:: (A) Vancomycin, (B) Polymyxin, (C) Rifampicin, (D) Teicoplanin
Answer is A. Vancomycin has the potential to release histamine by direct action on mast cells. Rapid i.v. injection has caused chills, fever, urticaria and intense flushing-called ' Red man syndrome'.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 806