21 year old female presents with history of mild bilater ptosis, proximal muscle weakness and easy fatiguability which among the following is best in diagnosis this condition: (A) Muscle biopsy, (B) Edrophonium test, (C) Repetitive nerve stimulation, (D) Electro myography
Answer is B. * For diagnosis inject edrophonium 2mg i.v Improvement- myasthenic crisis No improvement or worsening - cholinergic crisis. The Tensilon test uses the drug Tensilon (edrophonium) to help your doctor diagnose myasthenia gravis. Tensilon prevents the breakdown of the chemical acetylcholine, a neurotransmitter that nerve cells release to stimulate your muscles. This prevents muscles from being stimulated and makes muscles easy to tire Ref Harrison20th edition pg 2345