A non-caseating granuloma is seen in?: (A) Tropical sprue, (B) Celiac sprue, (C) Ulcerative colitis, (D) Crohn's disease
Answer is D. granuloma- distinctive type of chronic inflammation characterized by microscopic aggregation of activated macrophages (epithelioid cells) with scattered lymphocytes sometimes granulomas are associated with central necrosis caseating granuloma tuberculosis histoplasmosis non-caseating granulomas have no necrotic center Crohns disease sarcoidosis foreign body reactions leprosy ref Robbins 9/e p 98