Which one of the following is the major site for Purine nucleotide biosynthesis?: (A) Liver, (B) Erythrocytes, (C) Polymorphonuclear leukocytes, (D) Brain
Answer is A. Liver is the major site for Purine nucleotide biosynthesis. Erythrocytes, Polymorphonuclear leukocytes and Brain cannot produce purines. The purines are built upon a pre-existing ribose 5-phosphate.