Which of the following is an example of idiosyncratic reaction?: (A) Captopril - dry cough, (B) Isoniazid - hepatitis, (C) Haloperidol - extrapyramidal side effects, (D) Chloramphenicol - aplastic anemia
Answer is D. Ans. is'd'i.e., Chloramphenicol - aPlastic anemia(Ref: KDT P/e p. 851) Idiosyncratic reactions e.g.:Barbiturates cause excitement and mental confusion in some individuals.Quinine/quinidine cause cramps, diarrhoea, purpura, asthma and vascular collapse in some patients.Chloramphenicol produces non dose-related serious aplastic anaemia in rare individuals.