Ketone bodies are used by all except -: (A) Brain, (B) Heart muscles, (C) Skeletal muscles, (D) Hepatocytes
Answer is D. Ans. is 'd' i.e., Hepatocytes o Ketone bodies are synthesized by liver and are utilized by extrahepatic tissues like heart, muscles, renal cortex and brain (in starvation). o Liver cannot utilize ketone bodies because it lacks enzyme succinyl-CoA-acetoacetate CoA transferase, which is required for the activation of ketone bodies, o The first reaction in use of ketone bodies is activation of acetoacetate. o Liver lacks the enzyme CoA transferase; hence cannot utilize ketone bodies. RBCs can't use fatty acids because they don't have mitochondria