Thrombotic event is seen in all of following except:: (A) Paroxysmal nocturnal hemoglobinuria, (B) Disseminated intravascular coagulation, (C) Idiopathic thrombocytopenic purpura, (D) Heparin induced thrombocytopenia
Answer is C. *PNH is seen due to PIGA gene defect - Pancytopenia Altered function of platelets - | risk of thrombosis Especially in cerebral & hepatic veins - | Moality *DIC is thrombo-hemorrhagic disorder *Heparin-induced thrombocytopenia has ab produced against platelet factor 4. Also associated with | risk of thrombosis *In ITP, Immune dysfunction characterized by ab formation against Platelet antigen. - Pt sequestration Coombs +ve, Hemolytic anemia -| platelet count - Bleeding