LCAT deficiency increases the following: (A) Chylomicrons, (B) IDL, (C) VLDL, (D) HDL
Answer is D. * HDL is synthesized and secreted from both liver and intestine * Lecithin:cholesterol acyltransferase (LCAT) activity is associated with HDL containing apo A-I. * As cholesterol in HDL becomes esterified, it creates a concentration gradient and draws in cholesterol from tissues and from other lipoproteins thus enabling HDL to function in reverse cholesterol transpo * Absence of LCAT leads to block in reverse cholesterol transpo. HDL remains as nascent disks incapable of taking up and esterifying cholesterol. Ref:- Harper 30/e; pg num:- 249, 272