A patient suffering from AIDS is on Zidovudine, Lamivudine, Indinavir therapy, He develops pulmonary tuberculosis for which treatment is staed. Which of the following should be avoided in him: (A) INH, (B) Ethambutol, (C) Pyrazinamide, (D) Rifampicin
Answer is D. Refer KDT 6/e p 741 *Rifamipicin is a powerful enzyme inducer. It increases the metabolism of protease inhibitors and thus decreases the efficacy of anti retroviral therapy *another drug, rifabutin is devoid of these interactions and is the preferred agent for treatment of mycobacterial infections in patients