What is the impact on fetus in case of use of Indomethacin in utero in third trimester?: (A) Patent ductus aeriosus, (B) Early closure of ductus aeriosus, (C) Ventricular septal defect, (D) Atrial septal defect
Answer is B. Prostaglandins helps to keep ductus aeriosus open. Indomethacin inhibits prostaglandins levels | So, closure of ductus aeriosus | DOC for PDA