Which is gender specific adverse effect of valproate: (A) PCOD, (B) Weight gain, (C) Alopecia, (D) Hepatotoxicity
Answer is A. Valproate Adverse effects a) Hepatotoxicity Due to a metabolite of valproate. This metabolite is produced more if given with carbamazepine like drugs. So they produce more hepatotoxicity b) Pancreatitis c) Polycystic ovarian disease