glipizide differs from chlorpropamide in that it:: (A) Is more potent, (B) Is longer acting, (C) Does not lower blood sugar in nondiabetic subjects, (D) Is less prone to cause hypoglycemic reaction
Answer is A. (Ref: KDT 6/e p266) Second generation (like glipizide) sulfonylureas are more potent than first generation agents (like chlorpropamide). Chlorpropamide is the longest acting sulfonylurea. Sulfonylureas can cause hypoglycemia (even in non-diabetics) due to release insulin.