All of the following are true for patients with ulcerative colitis associated with primary sclerosing cholangitis (PSC), Except: (A) The may develop biliary cirrhosis, (B) May have raised alkaline phosphatase, (C) Increased risk of hilar Cholangiocarcinoma, (D) PSC reves after a total colectomy
Answer is D. PSC associated with ulcerative colitis eventually leads to biliary cirrhosis. Investigations reveal a cholestatic pattern in LFT with an elevation of serum alkaline phosphatase & gamma-glutamyltransferase. The prevalence of cholangiocarcinoma in patients with PSC ranges from 7 to 13%. Reference: Bailey & love&;s sho practice of surgery,25th edition, page no:1127; SRB&;s manual of surgery,5th edition, page no:658.