Drug ezetimibe act by?: (A) Enhancing excretion of bile acids, (B) Decreasing absorption of cholesterol, (C) Inhibiting HMG-CoA, (D) Inhibiting intracellular lipase
Answer is B. Ezetimibe acts by inhibiting the intestinal absorption of cholesterol and phytosterols. It interferes with a specific CH transpo protein NPC1C1 in the intestinal mucosa and reduces the absorption of both dietary and biliary CH. (REF. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D TRIPATHI-6th edition.Page No-618)