Microcytosis is seen in -: (A) Thalassemia, (B) Hb Lepore, (C) Hb bart's, (D) All of the above
Answer is D. Causes of microcytosis (MCV < 80fl)
• Iron deficiency anemia
• Thalassemia
• Sideroblastic anemia
• Anemia of chronic disease
In Hb Barts, all the four a chain genes are deleted resulting in formation of Barts Hb.
In Hb Lepore, there is nonhomologus fusion of b and d genes and forms an abnormal hemoglobin with total absence of normal b chain. It is one of the form of b thalassemia minor.