The antipsychotic with least incidence of extrapyramidal symptoms is:-: (A) Haloperidol, (B) Thiothixene, (C) Thioridazine, (D) Perphenazine
Answer is C. Typical Antipsychotics : Thioridazine causes minimum EPS (Marked central anticholinergic activity) Atypical Antipsychotic Agents : Risperidone causes maximum extrapyramidal symptoms (Potent D2 blocker) DRUG (TYPICAL ANTIPSYCHOTIC) EXTRAPYRAMIDAL SIDE EFFECTS Pimozide +++ Fluphenazine +++ Haloperidol +++ Thiothixene +++ Trifluoperazine +++ Loxapine ++ Triflupromazine ++ Chlorpromazine ++ Thioridazine +