Half-life of insulin is: (A) 1-2 min, (B) 4-6 min, (C) 10-12 min, (D) 12-16 min
Answer is B. The half-life of insulin in the circulation in humans is about 5 min. Insulin binds to insulin receptors, and some are internalized. It is destroyed by proteases in the endosomes formed by the endocytotic process.Ref: Ganong's, Review of Medical Physiology, Twenty-Third Edition, Page number: 318