Which of the following is a Polygenic disorder:: (A) Cystic fibrosis, (B) Phenylketonuria, (C) Multiple sclerosis, (D) Hypertension
Answer is D. d. Hypertension(Ref: Nelson's 20/e p 650, Ghai 8/e p 643)Polygenic disorders:Disorders caused by interactions between variant forms of genes and environmental factors.Occur when many polymorphisms, each with a modest effect and low penetrance, are co-inheritedE.g. HypertensionQ, Diabetes mellitus, Coronary Artery disease, Septal DefectsQ, Cleft lip