Medullary ca of thyroid is associated with increase in-: (A) Calcitonin, (B) Thyroglobulin, (C) T3, (D) T4
Answer is A. Medullary carcinomas of thyroid are neuroendocrine tumours derived from the parafollicular cells or C cells. They secrete calcitonin,the measurement of which plays an impoant role in the diagnosis and post operative follow - up of patients.Calcitonin is readily demonstrable within the cytoplasm of tumour cells as well as in stromal amyloid by immunohistochemical methods. Ref: Robbins and cotrans 9e Pg 1099