A middle aged man with chronuc renal failure is diagnostic to have sputum positive pulmonary tuberculosis. His creatinine clearance is 25ml /min. All of the following drugs need modification in doses except: (A) Isoniazid, (B) Streptomycin, (C) Rifamipicin, (D) Ethambutol
Answer is C. Refer Katzung 11/e p826 Rifamipicin is associated with bile Rifamipicin is secreted in bile So it does not require dose adjustment min renal failure