A 56-year-old man is surgically treated by a four-vessel coronary aery bypass graft procedure and placed on prophylactic daily aspirin therapy. Aspirin has been shown to prevent recurrent myocardial infarction through its ability to inhibit the synthesis of: (A) Adenosine diphosphate (ADP)., (B) Leukotriene B4 (LTB4 ), (C) Nitric oxide (NO)., (D) Thromboxane A2 (TXA2)
Answer is D. Aspirin Irreversibly inhibits the enzymes cyclooxygenase 1 and 2 Inhibits synthesis of Thromboxane A2 (TxA2). TxA2 promotes platelet aggregation,as does ADP. Aspirin inhibits platelet aggregation, which is an impoant early step in atherogenesis.