Sickle cell anemia is the clinical manifestation of homozygous genes for an abnormal haemoglobin molecule. The event responsible for the mutation in the b chain is:: (A) Inseion, (B) Deletion, (C) Non-disjunction, (D) Point mutation
Answer is D. - Sickle cell disease is a common hereditary hemoglobinopathy caused by point mutation resulting in replacement of Glutamic acid by Valine at 6th position of b-globin chain.