All of the following are associated with unconjugated bilirubin except?: (A) Cryoglobulinemia associated with hepatitis C, (B) History of gout, (C) Spherocytes in peripheral smear, (D) Gall stone
Answer is A. Cryoglobulinemia associated with hepatitis C doesn't cause rise in unconjugated bilirubin, instead it is associated with conjugated variety of bilirubin. =Gall stones such as pigmentary stones are associated with hemolysis which increases unconjugated bilirubin =Spherocytes also cause hemolysis =Gout patients on treatment with probenecid causes decrease in uptake of bilirubin resulting in elevated unconjugated bilirubin levels. Bilirubin metabolism