A newborn baby presented with profuse bleeding from the umbilical stump after bih. Rest of the examination and PT, APTT are within normal limits. Most of probable diagnosis is -: (A) Factor X deficiency, (B) Glanzmann thrombasthenia, (C) Von willebrand disease, (D) Bernad soulier disease
Answer is B. TEXT BOOK OF PATHOLOGY HARSHMOHAN 6TH EDITION PG NO 334 DEFECTIVE PLATELET AGGREGATION . In thrombasthenia (Glanzmann's disease), there is failure of primary platelet aggregation with ADP or collagen due to inherited deficiency of two of platelet membrane glycoproteins.