Which of the following is the most impoant effector pathway for action of Nitric Oxide:: (A) Adenylate cyclase pathway, (B) Phosphatidylinositol pathway, (C) Guanylate cyclase pathway, (D) MAP Kinase pathway
Answer is C. The most impoant effector pathway for NO is activation of the soluble form of guanylyl cyclase. Soluble guanylate cyclase (sGC) catalyses the conversion of guanosine 5&;-triphosphate (GTP) to cyclic guanosine 3&;5&;-monophosphate (cGMP) Ref: Harper