Which of the following RCC do not have papillary architecture in histology ?: (A) Xp11 translocation carcinoma, (B) Bellini duct carcinoma, (C) Succinate dehydrogenase-deficient RCC, (D) Papillary carcinoma
Answer is C. Succinate dehydrogenase deficient renal cell carcinoma (SDD-RCC) It is very rare type of RCC It is defined by WHO as a malignant epithelial tumor, composed of vacuolated eosinophilic to clear cells with loss of immunohistochemical expression of SDHB gene. Features : Characteristic flocculent cytoplasmic vacuoles with a pale eosinophilic, bubbly appearance and low grade nuclei Image : SDD-RCC showing cytoplasmic vacuoles which impas a bubbly appearance.