All of the following are true regarding penicillin G except:-: (A) Probenecid decreases it duration of action, (B) It is active against gram positive organisms, (C) It Splits into 6 amino penicillanic acid by amidase, (D) It acts by inhibiting cell wall synthesis
Answer is A. Probenecid inhibits tubular secretion and increase the duration of action of penicillin G Penicillin G is sho acting. To overcome this problem: Benzathine and procaine group can be added to penicillin G to make it long acting. Benzathine penicillin G is longest acting penicillin. Probenecid can be administered with penicillins. Former inhibits the tubular secretion. Penicillins have wide therapeutic index. A high initial dose can be used.