All have high hepatic clearance EXCEPT: (A) Labetalol, (B) Simvastatin, (C) Morphine, (D) Paracetamol
Answer is D. (D) Paracetamol HEPATIC CLEARANCE OF DRUGSLOWHepatic ClearanceINTERMEDIATEHepatic ClearanceHIGHHepatic Clearance* Carbamazepine* Caffeine* Lignocaine* Diazepam* Fluoxetine* Morphine* Ibuprofen* Midazolam* Pethidine* Phenytoin* Omeprazole* Propranolol* Warfarin* Paracetamol* Zidovudine> Low Hepatic Clearance does not mean that the drug is then cleared by the kidneys; it indicates that the capacity of the hepatic enzymes involved in the metabolism of the drug is low.