Which is the best prognosticator of survival from nasopharyngeal carcinoma?: (A) High angiogenesis in the tumor, (B) WHO type III histology, (C) Lung metastases, (D) WHO type I histology
Answer is B. WHO type PATHOLOGY Risk factor Other factors Survival/ Recurrence I 25% Keratinizing Squamous cell differentiated carcinoma Smoking Low risk population Older age Non familial factors 10% Survival II 12% Non keratinizing Squamous cell differentiated carcinoma EBV Preserved foods Familial factors 50% Survival III 60% Non keratinizing Squamous cell undifferentiated carcinoma EBV High risk population, Children Preserved foods Familial factors 60% Survival Best prognosis Type 3 NPC- Poorly differentiated, EBV Associated & Best prognosis The undifferentiated NPC havea higher local tumour control rate with therapy although theincidence of distant metastasis is also higher.