Which of the following is a differential of giant cell tumor?: (A) Ossifying fibroma, (B) Non-ossifying fibroma, (C) Osteogenic sarcoma, (D) Chondroblastoma
Answer is B. Eccentric lytic lesion with no calcification is the commonest differential. Calcification: Ossifying fibroma, chondroblastoma osteosarcoma hence non-ossifying fibroma is a preferred answer here. Non-ossifying fibroma Benign (non-cancerous) Eccentric Age <15 years Non-aggressivetumor Metaphyseal lesion Sclerotic margin Histologically Giant cell with foam cell Note: Closest differential is ABC.