Gluten sensitive enteropathy is strongly associated with:: (A) Blood group B, (B) HLA-DQ3, (C) HLA-DR4, (D) HLA-DQ2
Answer is D. Gluten enteropathy/Celiac Sprue It is associated with HLA -DQ2 Due to auto Ab against brush border epithelium which is present in the gut mucosa Clinical Feature-Osmotic diarrhoea Auto ab: Anti tissue transglutaminase Ab - Screening test Small intestinal mucosal Biopsy - Confirmatory test Treatment: No 'BROW'(Barley, Rye, Oats, Wheat) Only maize is allowed