Mechanism of action colchicine in acute gout: (A) Uric acid nephrolithiasis., (B) Deficiency of enzyme Xanthine oxidase, (C) Increase in serum urate concentration, (D) Renal disease involving interstitial tissues
Answer is B. * Gout is a hereditary disorder with increase in serum uric acid due to increased production, or decreased excretion of uric acid and uric salt. * Thought to be caused by lack of an enzyme needed to completely metabolise purines for renal excretion. REF : HARRISONS 21ST ED