Which is the most common preceding infection in bone marrow failure syndromes?: (A) Parvo B19, (B) EBV, (C) HIV, (D) Hepatitis
Answer is D. Most common infection preceding bone marrow failure syndrome is hepatitis. It is usually sero negative ( non-A, non- B, non - C ). It accounts for 5% of etiologies. Parvo virus can cause pure red cell aplasia, but it doesn't usually cause generalised bone marrow failure. Ref: Harrison's principles of internal medicine, 21st edition, page 664