Hemolysis is predominantly intravascular in which of the following conditions?: (A) Warm-type autoimmune hemolytic anemia, (B) PNH, (C) Cold-type autoimmune hemolytic anemia, (D) Hereditary spherocytosis
Answer is B. - Intravascular hemolysis (predominant) is seen in: Paroxysmal nocturnal hemoglobinuria (PNH) G6PD deficiency Paroxysmal cold hemoglobinuria (Cold hemolysin disease) - Extravascular hemolysis (predominant) is seen in: Hereditary spherocytosis Warm-type autoimmune hemolytic anemia Cold agglutinin disease (Cold-type AIHA) Sickle cell disease