The expression of the following oncogene is associated with a high incidence of medullary carcinoma of thyroid:: (A) p 53, (B) Her 2 neu, (C) RET proto oncogene, (D) Rb gene
Answer is C. - RET proto-oncogene is mutation is associated with medullary carcinoma of thyroid - RET proto-oncogene is mutated in MEN-2A & 2B syndromes, hence these are also associated with medullary carcinoma of thyroid. - Prophylactic thyroidectomy is indicated in pt with family history of RET mutation