A 23-year-old female presented with jaundice and pallor for 2 months. Her peripheral blood smear shows the presence of spherocytes. The most relevant investigation to arrive at a diagnosis is which of the following?: (A) Tests for PNH, (B) Osmotic fragility test, (C) Coombs test, (D) Reticulocyte count
Answer is C. Coombs test going to be positive in autoimmune hemolytic anemia; negative in hereditary spherocytosis. Thus, a differentiation between these conditions can be done.