The mechanism of action of cyclosporine is:: (A) Inhibits IL-2 receptors, (B) Inhibits TNF alpha, (C) Decrease in transcription of IL-2 gene, (D) Targets inactivated T cells
Answer is C. Cyclosporine calcineurin inhibitor inhibits the dephosphorylation of NFAT leading to blocked of T cell activation by preventing IL2 Transcription. Tacrolimus (FK506):- is also calcineurin inhibitor which binds FK506 binding protein. IL2 receptor are blocked by Basiliximab, Daclizumab. TNF alphaBlocker :- Infliximab