Malignant hypehermia is caused due to which of the following mechanism?: (A) Increased intracellular NA, (B) Decreased intracellular chlorine, (C) Increased intracellular Ca, (D) Increased serum K
Answer is C. The mechanism involves a sudden rise in intracellular calcium due to release of stored calcium in sarcoplasmic reticulum, stimulating contraction, rhabdomyolysis and a hypermetabolic state.(Refer: stoelting's pharmacology and physiology in anaesthetic practice, 5th edition, pg no.823)