The mitochondrial enzyme involved in the metabolism of clopidorgel and proton pump inhibitors is:: (A) CYP 2A, (B) CYP 2B, (C) CYP 2C19, (D) CYP 2D6
Answer is C. Ans. (C) CYP 2C19(Ref: Katzung 13th/e p80)Clopidogrel and proton pump inhibitors are metabolized mainly by CYP2C19 and by CYP3A4. Due to this reason there is potential of interaction between these two drugs