Waldenstrom's macroglobulinemia is characterized by all except: (A) IgE sereting clone of plasma cells, (B) Hyperviseosity symptoms, (C) Hepatosplenomegaly, (D) Lymphadenopathy
Answer is A. Waldenstrom macroglobulinaemia is a low grade lymphoplasmacytoid lymphoma associated with an Ig M paraprotein, causing clinical featurws of hyperviscosity syndrome.Other features include anemia,splenomegaly & lymphadenopathy. Reference:Davidson's principles &practice of medicine 22nd edition pg no 1045.