Not true regarding Waldenstrom&;s macroglobulinemia,: (A) Lymphadenopathy is usually present, (B) Blood viscosity increased, (C) Ig M immunoglobulin increased, (D) Hypercalcemia
Answer is D. WALDENSTROM'S MACROGLOBULINEMIAIt is a malignancy of lymphoplasmacytoid cells that secreted IgM. In contrast to myeloma, the disease was associated with lymphadenopathy and hepatosplenomegaly, but the major clinical manifestation was hyperviscosity syndrome.Reference: Harrison&;s principles of Internal Medicine; 19th edition; Chapter 136 Plasma Cell Disorders