Type 1 Dentinogenesis imperfecta is caused by mutation in:: (A) DMP-1 gene, (B) BSP- 1 gene, (C) DSPP gene, (D) SPP1 gene
Answer is C. Type 1 Dentinogenesis imperfecta is caused by a mutation in the DSPP gene (gene map locus 4q21.3), encoding dentin phosphoprotein and dentin sialoprotein. While Type 2 is caused by DMP-1, BSP-1, SPP1 gene.
Ref: Shafer's textbook of oral pathology 7th edition page55