Maternal serum Alpha-fetoprotein is raised in all the following conditions EXCEPT:: (A) Spina bifida, (B) Multiple pregnancy, (C) Omphalocele, (D) Down's syndrome
Answer is D. Ans. D. Down's syndromeCauses of Raised MSAFPa. Upper GI obstructionb. Wrong dates (under-estimation)c. Obstructive uropathyd. NTDe. Feto-maternal haemorrhagef. Congenital nephrosisg. CAML (Cystic adenomatoid malformation of the lung)h. Placental/cord tumorsi. Sacrococcygeal teratomaj. Multiple pregnancyk. Maternal liver diseasel. Male fetuses have higher MSAFPm. Abdominal wall defectsn. Afro-Caribbean ethnic backgroundo. Associated with increased risk of IUD/PPROM/IUGR/oligohydramnios/pre-eclampsiap. Smoking