Knudson's two stage hypothesis is for:: (A) Glaucoma, (B) Retinoblastoma, (C) Optic Glioma, (D) Meningioma
Answer is B. Ans. (b) RetinoblastomaRef Kanski 7/e, p. 520Deletion or inactivation of RB gene by two mutations (Knudson's two hit hypothesis) results in occurrence of retinoblastoma.