Drug causing Addison's disease is: (A) Ketoconazole, (B) Aminoglutethimide, (C) Cyclosporine, (D) Glucocoicoids
Answer is A. Addison's disease, also known as primary adrenal insufficiency and hypocoisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones A dose dependent decrease in serum hydrocoisone due to synthesis inhibition is noted with the use of ketoconazole. others-mitotane, metyrapone, aminoglutethimide, etomidate (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 763)