Which of these drugs DO NOT decrease angiotensin Il activity: (A) Enalapril, (B) Valsaan, (C) Nesiritide, (D) Omapatrilat
Answer is C. (Ref: Katzung 10/e p205, 286) ACE inhibitors and AT1, antagonists decrease angiotensin Il activity. Omapatrilat is a vasopeptidase inhibitor that acts by inhibiting two enzymes, ACE and NEP. As it inhibits ACE, it may also decrease angitotensin II activity. Nesiritide is a recombinant BNP and has no effect on angiotensin II activity.