A 24 year old unmarried woman has multiple nodular, cystic, pustular and comadonic lesions on face, upper back and shoulders for 2 years. The drug of choice for her treatment would be –: (A) Acitretin, (B) Isotretinoin, (C) Doxycycline, (D) Azithromycin
Answer is B. The DOC for nodulocystic acne is oral isotretinoin (13-Cis Retinoic acid)
Indications of isotretinoin →   Severe acne (>25 lesions), Nodulocystic lesions, Large nodular lesions, Moderate acne not responding to oral antibiotics (Recalcitrant acne).