Which of the following aminoglycosides has highest nephrotoxicity?: (A) Paramomycin, (B) Streptomycin, (C) Amikacin, (D) Neomycin
Answer is D. Small amounts that are absorbed from the gut or topical sites are excreted unchanged by kidney. This may accumulate in patients with renal insufficiency-cause fuher kidney damage and ototoxicity. Neomycin is contraindicated if renal function is impaired. ESSENTIALS OF MEDICAL PHARMACOLOGY page 750