The most important investigation in the given case to diagnose if the condition is a neoplasm?: (A) JAK-2, (B) EPO level, (C) PaO2, (D) Bone marrow aspiration and biopsy
Answer is A. Ans. (a) JAK-2The figure shows increased platelets in smear and increased megakaryocytes in bone marrow. To diagnose this as essential thrombocythemia (neoplasm); JAK-2 mutation analysis should be done.