True statement about neostigmine aa: (A) It is quaternary Ammonium compounds, (B) It is metabolized by liver, (C) It can cross blood brain barrier, (D) Prominent effect on cardiac muscle
Answer is A. Refer kDT 6/e p 101,102 neostigmine is a reversible cholinesterase inhibitor. It is a quaernary ammonium compound(lipid insoluble agent) So it doesn't cross blood brain barrier It is paly hydrolysed by serum cholinesterase and paly excreted unchanged by the Kidneys It possesses some agonistic action on Nm receptors