In a chronic smoker a highly malignant aggressive and metastatic lung carcinoma is: (A) Small cell carcinoma, (B) Squamous cell carcinoma, (C) Large cell carcinoma, (D) Adenocarcinoma
Answer is A. Cigarette smoking is most strongly associated with squamous cell carcinoma and small cell carcinoma. Small cell carcinoma variant is more malignant and metasizes Ref Harrison 19th edition pg 1702