Which of the following is the drug of choice for the treatment of inappropriate anti-diuretic hormone secretion:: (A) Frusemide, (B) Hydrochlorothiazide, (C) Spironolactone, (D) Demeclocycline
Answer is D. Answer is D (Demeclocycline): The treatment of choice for S1APH is water restriction. The drug of choice for SIAPH (when water restriction is unsuccessful is demeclocycline). Demeclocycline (a tetracycline) acts as an ADH antagonist.