All of the following statements about phenytoin are true except:: (A) It follows Saturation kinetics, (B) Anti-seizure activity closely resembles plasma concentration, (C) Does not depress CNS, (D) Cerebellar degeneration occurs on long-term administration
Answer is D. Phenytoin is not a CNS depressant; some sedation occurs at therapeutic doses, but this does not increase fuher with dose; rather toxic doses produce excitement and muscular rigidity. REF: ESSENTIALS OF MEDICAL PHARMACOLOGY KD TRIPATHI 8TH ED.