How does hyperammonemia inhibit TCA cycle?: (A) By depleting alpha ketoglutarate, (B) By depleting oxaloacetate, (C) By increasing concentration of alpha ketoglutarate, (D) By increasing concentration of oxaloacetate.
Answer is A. Build up of cummonemia which occurs in urea cycle disorder or advanced liver disease, inhibits TCA cycle by depleting alpha ketoglutarate.