In metabolism, all of the following reactions occur in phase one except?: (A) Oxidation, (B) Reduction, (C) Conjugation, (D) Deamination
Answer is C. Ans. C. ConjugationPhase-1 (Non-synthetic): (oxidation/reduction/hydroiysis/ cyclization/ Decyclization)a. Convert lipophilic compounds to more polar compounds, by introducing or unmasking a functional group such as OH,-NH2 .b. OXIDATION is the most common pathway in Phase-1 reactionc. Microsomal drug oxidations require CYP450, P450 reductase, NADPHQ & oxygend. REMEMBER oxidation includes dealkylation, deamination and hydroxylation