Which of the following antimicrobial shows time dependent killing?: (A) Ofloxacin, (B) Amikacin, (C) Penicillin, (D) Ciprofloxacin
Answer is C. Bactericidal agents can be divided into two groups: Agents that exhibit concentration-dependent killing (e.g. aminoglycosides and quinolones) Agents that exhibit time-dependent killing (e.g., b lactams and vancomycin).