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Table of Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Unit 1
Chapter 1: The Study of Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
1.1 The Science of Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
1.2 Themes and Concepts of Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
Chapter 2: The Chemical Foundation of Life . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
2.1 Atoms, Isotopes, Ions, and Molecules: The Building Blocks . . . . . . . . . . . . . . . 42
2.2 Water . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
2.3 Carbon
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68
Chapter 3: Biological Macromolecules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
3.1 Synthesis of Biological Macromolecules . . . . . . . . . . . . . . . . . . . . . . . . . 88
3.2 Carbohydrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92
3.3 Lipids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
3.4 Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112
3.5 Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
Unit 2
Chapter 4: Cell Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
4.1 Studying Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
4.2 Prokaryotic Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
4.3 Eukaryotic Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156
4.4 The Endomembrane System and Proteins . . . . . . . . . . . . . . . . . . . . . . . . 166
4.5 Cytoskeleton
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
4.6 Connections between Cells and Cellular Activities . . . . . . . . . . . . . . . . . . . . 178
Chapter 5: Structure and Function of Plasma Membranes . . . . . . . . . . . . . . . . . . . 195
5.1 Components and Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
5.2 Passive Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
5.3 Active Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 212
5.4 Bulk Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 218
Chapter 6: Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237
6.1 Energy and Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238
6.2 Potential, Kinetic, Free, and Activation Energy . . . . . . . . . . . . . . . . . . . . . . 242
6.3 The Laws of Thermodynamics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 252
6.4 ATP: Adenosine Triphosphate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
6.5 Enzymes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 259
Chapter 7: Cellular Respiration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
7.1 Energy in Living Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 282
7.2 Glycolysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 286
7.3 Oxidation of Pyruvate and the Citric Acid Cycle . . . . . . . . . . . . . . . . . . . . . . 291
7.4 Oxidative Phosphorylation
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 296
7.5 Metabolism without Oxygen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
7.6 Connections of Carbohydrate, Protein, and Lipid Metabolic Pathways . . . . . . . . . . 307
7.7 Regulation of Cellular Respiration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311