def buttonPress(*args):
    searchB.config(state='active')
searchB.update()
time.sleep(0.2)
searchB.config(state='normal')
searchB = Label(main, text='Search', bg='#fecc14', fg='Black',
    activebackground='Red', highlightbackground='Black')
searchB.bind('<Button-1>', startSearch)
searchB.pack()
How to change the foreground or background colour of a Tkinter Button on Mac OS X?