filter_rows = [(2752937066, 'http://members.aye.net/~gharris/blog/'), (
    3799762538, 'http://www.coxandforkum.com/')]
qry = session.query(Page)
qry = qry.filter((func.cast(Page.url_crc, String) + '|' + Page.url).in_([
    '{}|{}'.format(*_frow) for _frow in filter_rows]))
print(qry)
How to write multi column in clause with sqlalchemy