from win32com.client import Dispatch
xlApp = Dispatch('Excel.Application')
xlApp.Visible = 1
xlApp.Workbooks.Add()
xlApp.ActiveSheet.Cells(1, 1).Value = 'Python Rules!'
xlApp.ActiveWorkbook.ActiveSheet.Cells(1, 2).Value = 'Python Rules 2!'
xlApp.ActiveWorkbook.Close(SaveChanges=0)
xlApp.Quit()
xlApp.Visible = 0
del xlApp
Driving Excel from Python in Windows