df = pd.DataFrame([['A', 'C', 'A', 'B', 'C', 'A', 'B', 'B', 'A', 'A'], [
    'ONE', 'TWO', 'ONE', 'ONE', 'ONE', 'TWO', 'ONE', 'TWO', 'ONE', 'THREE']]).T
Pandas DataFrame Groupby two columns and get counts