test_image = 'Fedora_19_with_GNOME.jpg'
original = Image.open(test_image)
original.show()
width, height = original.size
left = width / 4
top = height / 4
right = 3 * width / 4
bottom = 3 * height / 4
cropped_example = original.crop((left, top, right, bottom))
cropped_example.show()
Cropping an image with Python Pillow