if __name__ == '__main__':
    connect = MySQLdb.connect(host='localhost', port=3306, user='xxx',
        passwd='xxx', db='xxx', charset='utf8')
cursor = connect.cursor()
cursor.execute(
    """
       UPDATE tblTableName
       SET Year=%s, Month=%s, Day=%s, Hour=%s, Minute=%s
       WHERE Server=%s
    """
    , (Year, Month, Day, Hour, Minute, ServerID))
Оператор обновления Python MYSQL