src = '/home/mediacenter/Downloads'
dst = '/media/mediacenter/SAMSUNG/SERIES'
source = os.listdir(src)
destination = os.listdir(dst)
for filename in source:
    file_src = src + '/' + str(filename)
file_dst = dst + '/' + str(filename)
if filename not in destination and os.path.isdir(file_src) is False:
    os.system('mv %s %s' % (file_src, file_dst))
elif filename not in destination and os.path.isdir(file_src) is True:
    os.system('mv %s %s' % (file_src, dst))
Python Comparing two lists of strings for similarities