This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diseases of orbit, Lids and lacrimal apparatus, Subject name: Ophthalmology
The most common second malignant in survival of retinoblastoma 
Select and explain. 
A. Thyroid cancer, B. Nasopharyngeal carcinoma, C. Optic glioma, D. Osteosarcoma
D: Osteosarcoma
Answer: D: Osteosarcoma 
Explanation: Osteogenic sarcoma is the most common ocular malignancy in retinoblastoma. IT occurs in hereditary cases Refer khurana 6/e p 421