This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Introduction, Subject name: Pathology
Males are more commonly affected than females in which of the following genetic disorders? 
Select and explain. 
A. Autosomal recessive disorder, B. Autosomal dominant disorder, C. X-linked recessive disorder, D. X-linked dominant disorder
C: X-linked recessive disorder
Answer: C: X-linked recessive disorder 
Explanation: Analysis ofX-linked recessive disorders Males have an X and Y chromosome. No corresponding locus for a mutant allele of the X chromosome on the Y chromosome. Mutant recessive gene on the X chromosome expresses itself in a male child because it is not suppressed by a normal allele. Whereas in the female, the presence of a normal allele on other X-chromosome prevents the expression of the disease. Females only act as carriers.