This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The following statements regarding histamine are true, except: 
Select and explain. 
A. It can be used as a positive control injection during allergy skin testing, B. In the dermis, it evokes pain and sometimes itching, C. Bronchospasm is induced by histamine by  blockage of H2 receptors, D. It tends to dilate larger blood vessels
D: It tends to dilate larger blood vessels
Answer: D: It tends to dilate larger blood vessels 
Explanation: Histamine characteristically causes dilation of the finer blood vessels and tends to constrict the larger blood vessels, it is used as a positive control injection during allergy skin testing. It can stimulate various nerve endings and in the dermis it evokes pain and sometimes itching. Contraction of bronchial smooth muscles is due to activation of H1 receptors and relaxation is due to activation of H2 receptors. Hence, blockade of H2 receptors can potentiate histamine-induced bronchospasm.