This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
Alteplase differs from streptokinase as it 
Select and explain. 
A. Is longer acting, B. Is derived from human kidney, C. Is cheap, D. Activates plasminogen bound to fibrin
D: Activates plasminogen bound to fibrin
Answer: D: Activates plasminogen bound to fibrin 
Explanation: Refer KDT 6/e p606 Fibrinolytics are the drugs which activate plasminogen to form plasmin and thus helps in lysis of thrombus These drugs can cause bleeding as the major adverse effect due to lysis of physiological thrombi as well as due to excessive amount of plasma generated in the circulation