This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Anaesthesia
Local anesthetic acts by: 
Select and explain. 
A. Blocking sodium gated channel, B. Blocking calcium gated channel, C. Blocking potassium gated channel, D. Blocking chloride gated channel
A: Blocking sodium gated channel
Answer: A: Blocking sodium gated channel 
Explanation: NORMAL LOCAL ANESTHETIC Sodium passess through voltage gated sodium channel and cause change in membrane potential and cause depolarization. Local anesthetic attatches to sodium channel and prevents propogation & depolarization. LA also has mild action on potassium calcium and NMDA channels