This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Causes for less bioavailability - 
Select and explain. 
A. High first pass metabolism, B. Increased absorption, C. IV drug administration, D. High solubility
A: High first pass metabolism
Answer: A: High first pass metabolism 
Explanation: Ans. is 'a' i.e., High first pass metabolism o Causes for less bioavailability. Incomplete absorption o High first pass metabolism. About other options Increased absorption increases bioavailability. o I.V. administration has 100% bioavailahi I ity. High lipid solubility causes more absorption and better bioavailability.