This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
Treatment of choice in acute Bipolar disorder 
Select and explain. 
A. Valproate, B. Lamotrigine, C. Lithium, D. All of the above
C: Lithium
Answer: C: Lithium 
Explanation: Lithium