This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T., Subject name: Pathology
Histopathological finding of gluten hypersensitivity is? 
Select and explain. 
A. Crypt hyperplasia, B. Increase in thickness of the mucosa, C. Distal intestine involvement, D. Villous hypertrophy
A: Crypt hyperplasia
Answer: A: Crypt hyperplasia 
Explanation: Ans. is 'a' i.e., Crypt hyperplasia Histopathological findings of gluten sensitivity enteropathy* Villous atrophy and Crypt hyperplasia with decrease in villus: crypt ratio.* Loss of microvilli brush border.* Inflammatory cells are present in lamina propria : plasma cells, macrophages, lymphocytes, eosinophils and mast cells.* One of the characteristic feature is that overall mucosal thickness remains same (as villous atrophy is compensated by crypt hyperplasia).* Mainly proximal intestine is involved.