This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
Mechanism of action of duloxetine is ? 
Select and explain. 
A. Selective Inhibition of serotonin reuptake, B. Selective inhibition of nor-epinephrine reuptake, C. Selective inhibition of both serotonin and nor-epinephrine reuptake, D. None of the above
C: Selective inhibition of both serotonin and nor-epinephrine reuptake
Answer: C: Selective inhibition of both serotonin and nor-epinephrine reuptake 
Explanation: Ans. C. Selective inhibition of both serotonin and nor-epinephrine reuptakeDuloxetine, is a drug classified under serotonin-norepinephrine reuptake inhibitors (sNRJs).At lower doses it is more prominent serotonin reuptake inhibitor.Whereas at higher doses it is more prominent inhibitor of nor-epinephrine reuptake.It has minimal dopamine agonist action.