This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
The laboratory evidence of flare in SLE is: 
Select and explain. 
A. Increase in titre of anti-dsDNA, B. Increase in titre of ANA, C. Increase in anti-Sm, D. Elevation of ESR
A: Increase in titre of anti-dsDNA
Answer: A: Increase in titre of anti-dsDNA 
Explanation: SLE FLARE: LAB RESULTS Increases in quantities of anti-dsDNA herald a flare, paicularly of nephritis or vasculitis It may be associated with declining levels of C3 or C4 complement. Antibodies to Sm is specific for SLE and assist in diagnosis; anti-Sm antibodies do not correlate with disease activity or clinical manifestations. Ref: Harrison, E-18, P-2735