This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
Deficiency of which of the following vitamins leads to lactic acidosis? 
Select and explain. 
A. Riboflavin, B. Thiamine, C. Niacin, D. Pantothenic acid
B: Thiamine
Answer: B: Thiamine 
Explanation: Thiamine is needed for the conversion of pyruvate to acetyl-CoA. In the absence of thiamine, pyruvate is channeled to lactate leading accumulation of L-lactate.