This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Which of the following opioid should not be used with MAO inhibitors? 
Select and explain. 
A. Morphine, B. Pentazocine, C. Buprenorphine, D. Pethidine
D: Pethidine
Answer: D: Pethidine 
Explanation: Ref: KD Tripathi 6/e p440 Most of Pethidine is metabolized by MAO-A and is inactivated. Small amount is conveed to nor-Pethidine, which has CNS stimulant propeies. Therefore if combined with MAO inhibitors, most of Pethidine will form nor-Pethidine and the risk of seizures will increase.