This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Histamine, 5-HT and PGs, Subject name: Pharmacology
All of the following statements are true regarding ondansetron except:- 
Select and explain. 
A. It is antiemetic of choice for chemotherapy induced vomiting, B. It is a 5-HT3 receptor antagonist, C. It has significant drug interactions, D. It may possess 5-HT4 agonism
C: It has significant drug interactions
Answer: C: It has significant drug interactions 
Explanation: ONDANSETRON Main mechanism of action of ondansetron is 5HT3 antagonism. It has minor 5HT 4 agonist action which is clinically insignificant. It does not block dopaminergic receptors. It is drug of choice for chemotherapy induced vomiting, radiation induced vomiting and post-operative vomiting. No clinically significant drug interactions have been noted with ondansetron