This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
A 50 year old female with end stage renal disease (ESRD), develops pulmonary tuberculosis. Which one of the following drugs should be used in a reduced dose? 
Select and explain. 
A. Rifampicin, B. Isoniazide, C. Pyrazamide, D. Ethambutol
D: Ethambutol
Answer: D: Ethambutol 
Explanation: None