This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Membrane Structure & Function, Subject name: Biochemistry
Degradation of a substance takes place in which part of the cell: 
Select and explain. 
A. Mitochondria, B. Nucleus, C. Lysosome, D. ER
C: Lysosome
Answer: C: Lysosome 
Explanation: Ans: c (Lysosome) Ref: Vasudevan, 4th ed,p. 17Degradation of a substance takes place in lysosomes. Phagosomes fuse with lysosomes to form phagolysosomes, inside which particles are digested.Lysosomal storage disease:DiseaseEnzyme deficiencyMajor accumulating metaboliteGlycogenosesType II (Pompes disease)Lysosomal glucosidaseGlycogenSphingolipidoses GM 1GMl gangliosideGM 1 gangliosideGM 2Beta galactosidaseGM 2 gangliosideTay sachs diseaseHexosaminidase A Sulfatidoses Gaucher diseaseGlucocerebrosidaseGlucocerebrosideNiemann Pick diseaseSphingomyelinaseSphingomyelinMucopolysaccharidoses MPS 1 (Hurler)L-IduronidaseHeparan sulfate Dermatan sulfateMPS 11 (Hunter)L- Iduronosulfate sulfataseHeparan sulfate Dermatan sulfate