This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Cancer, Subject name: Pharmacology
Most emetogenic anti CA drug: 
Select and explain. 
A. 5 FU, B. Methotrexate, C. Cisplatin, D. All
C: Cisplatin
Answer: C: Cisplatin 
Explanation: Ref: Katzung 14th ed. pg. 956; KDT, 6th ed. pg. 828* Cisplatin is a platinum coordination complex that is hydrolyzed intracellularly to produce a highly reactive moiety which causes cross linking of DNA by platinum compound.* It is a highly emetic drug. Antiemetics are routinely administered before infusing cisplatin.* DOC for cisplatin induced vomiting: Ondansetron* Major s/e of cispltin: Ototoxicity and nephrotoxicity.