This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Gene responsible for Van der woude syndrome: 
Select and explain. 
A. IRF6, B. FGFR2, C. HGHF2, D. GAT02
A: IRF6
Answer: A: IRF6 
Explanation: Mutations in the IRF6 gene that cause van der Woude syndrome prevent one copy of the gene in each cell from making any functional protein. A shortage of the IRF6 protein affects the development and maturation of tissues in the face, resulting in the signs and symptoms of van der Woude syndrome.