This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation, Subject name: Pathology
Which mediator of inflammation does NOT cause fever? 
Select and explain. 
A. IL-1, B. TNF-a, C. Nitric Oxide, D. Prostaglandin
C: Nitric Oxide
Answer: C: Nitric Oxide 
Explanation: PYROGENS: Exogenous pyrogen : LPS Endogenous pyrogen : IL1/TNF alpha - NO is free radical causes vasodilation.