This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autoimmune Diseases, Subject name: Pathology
Least likely associated with SLE - 
Select and explain. 
A. Anti ds DNA, B. Anti Sm, C. Anti topoisomerase, D. Anti histone
C: Anti topoisomerase
Answer: C: Anti topoisomerase 
Explanation: Ans. is 'c' i.e., Anti topoisomerase Best screening test for SLE is demonstration of antinuclear antibodies :o Most sensitive test for SLE- Anti nuclear antibodies (ANA).o Most specific test for SLE- Anti ds DNA, Anti Sm.