This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The most common prescription medication for sialorrhea 
Select and explain. 
A. Glycopyrrolate, B. Atropine sulphate, C. Scopolamine, D. Amitriptyline
A: Glycopyrrolate
Answer: A: Glycopyrrolate 
Explanation: Traditional medications for the treatment of drooling target the reduction of saliva production using anticholin- ergic mechanisms. While they will reduce salivary output, they do not treat the underlying neuromuscular problems, so some patients may find the anticholinergic side effects out - weigh the benefit of the drug. Additionally, the drying effect these medications have can lead to xerostomia, especially if the patient has a constant open mouth. Glycopyrrolate is the most common prescription medication for sialorrhea and drooling , with atropine sulfate, scopolamine, amitriptyline, and benztropine also being reported in the literature. OnabotulinumtoxinA (Botox ) injections into salivary glands with ultrasonic guidance have shown to be of some benefit in patients who have failed or are intolerant to anticholinergics