This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Changes seen in early stage of type-2 diabetes mellitus 
Select and explain. 
A. Decreased output of glucose from liver, B. Increase in C-peptide, C. Increase in GIP, D. All of the above
C: Increase in GIP
Answer: C: Increase in GIP 
Explanation: Answer- C. Increase in GIPDuring the induction of insulin resistance,increased glucagon levels and increased glucose-dependent insulinotropic polypeptide (GIP) level accompany glucose intolerance. In the progression from normal to abnormal glucose tolerance, pospranadial blood glucose levels increase first. Eventually, fasting hyperglycemia develops as suppression of hepatic glconeogenesis fails.