This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Toxicology - 1, Subject name: Forensic Medicine
Groote Eylandt syndrome is due to the toxicity of:- 
Select and explain. 
A. Manganese, B. Magnesium, C. Thallium, D. Antimony
A: Manganese
Answer: A: Manganese 
Explanation: Clinical Features of manganese toxicity Acute manganese poisoning is extremely rare. Chronic exposure to manganese dust or fumes results in the following: Dyspnoea, bronchitis, pneumonia. The manganese miners on an Australian island (Groote Eylandt) have been repoed to be afflicted with a peculiar neurological disease characterised by upper motor neuron and cerebellar signs, and oculomotor symptoms (Angurugu syndrome or Groote Eylandt syndrome). Parkinson-like syndrome (manganism)--tremor, rigidity, ataxia, amnesia, and abnormal gait. In addition, there may be nystagmus, paraesthesia, "whispering speech", lumbosacral pain, urinary incontinence, impotence, etc. Manganese madness ("Locura manganica")--insomnia, confusion, anxiety, hallucinations, and bizarre behaviour. "Metal fume fever" has been repoed after inhalation exposure to manganese oxide fumes