This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
IN activated protien C resistent disorder due to inactivation ? 
Select and explain. 
A. factor 8, B. factor 5, C. factor 13, D. factor 4
B: factor 5
Answer: B: factor 5 
Explanation: Factor V Leiden mutation * Factor V Leiden is an autosomal dominant condition that exhibits incomplete dominance and results in a factor V variant that cannot be as easily degraded by activated Protein C. * The gene that codes the protein is referred to as F5. Mutation of this gene is a single nucleotide polymorphism located on chromosome 1 in exon 10 * As a missense substitution it changes a protein&;s amino acid from arginine to glutamine. ref : robbins 10th ed