This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
True statement regarding Hirschsprung's disease – 
Select and explain. 
A. Giant ganglia are present, B. Mucosa is involved and show foldings, C. Manometry excludes the disease, D. Rectal biopsy is contraindicated in infants
C: Manometry excludes the disease
Answer: C: Manometry excludes the disease 
Explanation: Anorectal manometry is a useful screening procedure for the diagnosis of Hirschsprung's disease. A normal response in course of manometric evaluation precludes diagnosis of Hirschsprung's disease.
However the confirmation of diagnosis in case of Hirschsprung's disease is done by rectal biopsy.