This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following statements is false about Acyclovir- 
Select and explain. 
A. It inhibits DNA synthesis and viral replication, B. It is effective against influenza, C. It has low toxicity for host cells, D. Renal impairment necessitates dose reduction
B: It is effective against influenza
Answer: B: It is effective against influenza 
Explanation: Ans. is 'b' i.e., It is effective against influenza Acyclovir o It is a deoxygunosine analogue - inhibits DNA synthesis by ? Inhibits herpes virus DNA polymerase competitively. Gets incorporated in viral DNA and stops lengthening of DNA strand. The terminated DNA inhibits DNA polymerase irreversibly. o It is preferentially taken up by the virus infected cells. Because of selective generation of the active inhibitor in the virus infected cells and its greater inhibitory effect on viral DNA synthesis, acyclovir has low toxicity for host cells. o It is active against herpes group of virus (HSV-l> HSV-2 > VZV = EBV. CMV is not inhibited). o Acyclovir is primarily excreted unchanged in urine, both by glomerular filtration and tubular secretion. Renal impairment necessitates dose reduction.