This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous System, Subject name: Pathology
Which of the following condition is shown below? 
Select and explain. 
A. Plexiform neurofibroma, B. Von Hippel Lindau syndrome, C. Marfan syndrome, D. Tuberous sclerosis
A: Plexiform neurofibroma
Answer: A: Plexiform neurofibroma 
Explanation: Ans. (A) Plexiform neurofibroma(Ref: Robbins and Cotran Pathologic Basis of Disease 10th ed; pg. 326)NF-1Gene mutated is located on chromosome 17qCharacterised by cafe au lait spots, Lisch nodules, dysplasia of lesser wing of sphenoid and risk of developing meningiomaNF-2Due to mutation in gene located on chromosome 22qCharacterised by cafe au lait spots and bilateral vestibular schwannomaMarfan's SyndromeDue to defect in fibrillinCharacterised by hyperflexibility of joints, subluxation of lens and cardiac problems (mitral valve prolapse, bicuspid aortic valve)Von Hippel Lindau SyndromeGene is located on chromosome 3pHigh risk of developing clear cell renal cell carcinoma and cerebellar hemangioblastoma