This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Mutation in the oxidative enzymes (peroxisomes) could lead to: 
Select and explain. 
A. Zellweger's syndrome, B. Gaucher's disease, C. Epidermolysis bullosa, D. Leber's neuropathy
A: Zellweger's syndrome
Answer: A: Zellweger's syndrome 
Explanation: Most cases of zellweger syndrome are due to mutations in genes involved in the biogenesis of  peroxisomes.
This condition is apparent at birth and is characterized by profound neurologic impairment, victims  often dying within a year.
The number of peroxisomes can vary from being almost normal to being virtually absent in some  patients.

Key Concept:
Mutation in peroxisomes can lead to Zellweger’s syndrome.
Ref : Harper’s illustrated biochemistry, 31st edition.