This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Amikacin (Amikin) is given to a client with E-coli infection. The nurse advises the client to report which of the following symptoms immediately? 
Select and explain. 
A. Muscle pain., B. Constipation., C. Fatigue., D. Hearing loss
D: Hearing loss
Answer: D: Hearing loss 
Explanation: Amikacin is an aminoglycoside. Side effects of this medication includes ototoxicity (Hearing loss), confusion, disorientation, gastrointestinal irritation, palpitations, blood pressure changes and nephrotoxicity.

Options A, B, and C are not related with the medication.