This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
All of the following are recognized effects of combined oral contraceptives except 
Select and explain. 
A. Breakthrough bleeding, B. Decreased risk of endometrial cancer, C. Increased risk of ischemic stroke, D. Increased risk of colon cancer
D: Increased risk of colon cancer
Answer: D: Increased risk of colon cancer 
Explanation: Adverse effects of OCP- breakthrough bleeding, coronary and cerebral thrombosis resulting in MI or stroke, increased incidence of genital carcinoma-like vaginal, cervical, breast cancers. It has a protective effect against endometrial carcinoma due to progesterone (Ref.Essentials of medical pharmacology TD Tripathi 7th edition page no.325,326)