This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following changes in C-MYC oncogene may be associated with colonic malignancy? 
Select and explain. 
A. Point mutation, B. Amplification, C. Rearrangement, D. Deletion
B: Amplification
Answer: B: Amplification 
Explanation: C- MYC amplification may be responsible for Ca breast, Ca colon, Ca stomach and lung. L - MYC amplification is associated with Ca lung and bladder. N- MYC amplification is associated with neuroblastoma and Ca lung. Ref: Harrison, 17th Edition, Page 496