This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
6 months old infant with Hb of 6 gm% has anaemic features with peripheral blood showing target cells. Family history of similar complaints is (Positive). Diagnosis can be best done with which of the following – 
Select and explain. 
A. Hb electrophoresis, B. ELISA, C. Coomb's Test, D. Osmotic fragility
A: Hb electrophoresis
Answer: A: Hb electrophoresis 
Explanation: Presence of :


Anaemia (Hb < 6%),  
Target cells,
Increase reticulocytes suggests the diagnosis of thalassemia.


Thalassemia is a hemoglobin disorder. Hemoglobin disorders are diagnosed by electrophoresis.
Diagnosis of thalassemia is confirmed by serum electrophoresis.