This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Gynaecology & Obstetrics
Most specific marker for neural tube defects is 
Select and explain. 
A. Alpha-fetoprotein, B. Unconjugated estriol, C. Acetylcholinesterase, D. Pseudocholinesterase
C: Acetylcholinesterase
Answer: C: Acetylcholinesterase 
Explanation: Both alpha-fetoprotein and acetylcholinesterase in amniotic fluid are markers for neural tube defects. But acetylcholinesterase is the most specific marker. Ref : Dutta book of obstetrics 8th Ed