This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The most appropriate drug used for chelation therapy in beta thalassemia major is - 
Select and explain. 
A. Oral desderrioxamine, B. Oral deferiprone, C. Intramuscular EDTA, D. Oral Succimer
B: Oral deferiprone
Answer: B: Oral deferiprone 
Explanation: Ans. is 'b' i.e., Oral deferiprone Desferrioxamine is poorly absorbed from GIT and hence not recommended for oral administration, although it continues to be the chelating agent of choice for parentral administration. o Deferiprone is a recently introduced orally active iron chelating agent meant to be used as an alternative to injected desferrioxamine. o Oral Deferiprone is prefered over oral desferrioxamine. Remember o For acute iron poisoning desferioxamine is the DOC. o For chronic iron overload, e.g. thalassemia, oral deferipone is the DOC.