This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diagnosis in obstetrics, Subject name: Gynaecology & Obstetrics
Maternal Alpha-fetoprotein concentration in serum is elevated in all except : 
Select and explain. 
A. hepatoma, B. Hepatoblastoma, C. Endodermal sinus tumor, D. Fetal Down's syndrome
D: Fetal Down's syndrome
Answer: D: Fetal Down's syndrome 
Explanation: AFP :It is increased in the circulation of patients with hepatocellular carcinoma teratocarcinoma of ovary pregnancy with fetal malformations of neural tube In nonpregnant females normal value is <15ng/dl.A AFP value of >300ng/dl is often associated with cancer,and nonmalignant liver diseases TEXTBOOK OF BIOCHEMISTRY,D.M.VASUDEVAN,pg no:576,6th edition and refer to previous question