This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
What is the histological appearance of brain in CJD? 
Select and explain. 
A. Neuronophagia, B. Micro abscess, C. Demyelination, D. Spongiform changes
D: Spongiform changes
Answer: D: Spongiform changes 
Explanation: CID(Creutfeldt Jakeb Disease) is a prion disease characterised by spongiform changes in the brain.