This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carcinoma Cervix, Subject name: Gynaecology & Obstetrics
All of the following changes are seen in dysplasia of squamocolumnar junction, except: 
Select and explain. 
A. Breaking of basement membrane, B. Change of epithelium, C. Hyperchromatic nuclei, D. Increased mitotic figure
A: Breaking of basement membrane
Answer: A: Breaking of basement membrane 
Explanation: Ans. is a, i.e. Breaking of basement membraneRef: Robbin's 7th/ed, pl076, Shaw 15th/ed, p400Dysplasia: Represents a change in which there is alteration in cell morphology and disorderly arrangement of the cells of the stratified squamous epithelium. It is a premalignant lesion.Characteristics of Dysplastic cell:* Vary in sizeQ, shapeQ and polarityQ.* Have altered nucleo-cytoplasmic ratio (N/C ratio is increased).Q* Have large, irregular hyperchromatic nuclei with marginal condensation of chromatin material.Q* Have several mitotic figures.* The basement membrane, however, is intact and there is no stromal infiltration.