This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Osteoporosis, Sex Hormones and OCPs, Subject name: Pharmacology
A serious adverse effect seen with zoledronate is? 
Select and explain. 
A. Anterior uveitis, B. Ventricular fibrillation, C. Peptic ulcer, D. Acute renal failure
D: Acute renal failure
Answer: D: Acute renal failure 
Explanation: Zoledronate Intravenous 3rd generation bisphosphonateseffective in the management of hypercalcemia Rapid normalization of S. Ca2+ S/E - Severe hypocalcemia Renal toxicity, Osteonecrosis of the jaw