This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
Steroid resistant nephrotic Syndrome- 
Select and explain. 
A. Nephrin, B. Alphanactinin-4, C. Podocin, D. Transient receptor Potential - 6
C: Podocin
Answer: C: Podocin 
Explanation: Mutation in NHPS2 results in a syndrome of a steroid-resistant nephrotic syndrome of childhood onset. Affected children show pathologic features of FSGS(focal segmental glomerulosclerosis). A distinctive pattern of autosomal recessive FSGS results from a mutation in the NPHS2 gene, which maps to chromosome 1q25-q31 and encodes the protein product podocin. Podocin has also been localized to the slit diaphragm.mutations in NPHS2 result in a syndrome of steroid-resistant nephrotic syndrome of childhood onset. FromPATHOLOGIC BASIS OF DISEASE ROBBINS 8th edition pg no:927