This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
Howell jolly bodies are seen in? 
Select and explain. 
A. Iron deficiency anemia, B. Hemolytic anemia, C. Polycythemia vera, D. Multiple myeloma
B: Hemolytic anemia
Answer: B: Hemolytic anemia 
Explanation: Ans. is 'b' i.e. Hemolytic anemia Howell-Jolly bodies (HJ bodies)* These are round solid staining, dark-blue to purple inclusions. They are nuclear remanants predominatly composed of DNA.* The presence of Howel-Jolly bodies is associated with hemolytic anemia, megaloblastic anemia, hereditary spherocytosis, myelodysplastic syndrome, post splenectomy and after physiological atrophy of spleen.* Although HJ bodies are seen in all these conditions, they are most common after splenectomy.