This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Most common cause of Mobius syndrome is by use of which of the following drug in pregnancy ? 
Select and explain. 
A. Misoprostol, B. Thalidomide, C. Methotrexate, D. Dinoprostone
A: Misoprostol
Answer: A: Misoprostol 
Explanation: Mobius syndrome is extremely rare congenital condition characterized by facial paralysis and inability to move the eye laterally (abbduction). It results due to paralysis of sixth and seventh cranial nerves, important causes of this syndrome are:

Birth trauma
Use of misoprostol in mother during pregnancy
Use of thalidomide in mother during pregnancy
Use of cocaine in mother during pregnancy