This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
A one year old child having leukocoria was detected to be having a unilateral, large retinoblastoma filling half the globe. Current therapy would involve – 
Select and explain. 
A. Enucleation, B. Chemotherapy followed by local dyes, C. Direct Laser ablation using photodynamic cryotherapy, D. Scleral radiotherapy followed by chemotherapy.
A: Enucleation
Answer: A: Enucleation 
Explanation: Tumor involving less than half of the globe → Multimodal therapy (Chemoreduction followed by local destruction).
Tumor involving half or more of the globe → Enucleation.