This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Anticipation is seen in - 
Select and explain. 
A. Translocation, B. Chromosome breaking, C. Trinucleotide-repeat expansion, D. Mitochondrial mutation
C: Trinucleotide-repeat expansion
Answer: C: Trinucleotide-repeat expansion 
Explanation: Ans. is 'c' i.e., Trinucleotide-repeat expansion Anticipation o Anticipation is a phenomenon where by the symptoms of a genetic disorders become apparent at an earlier age as it is passed to next generation. In most cases, an increased severity of symptoms is also noted. In triplet nucleotide repeat mutation, the DNA fragment is unstable and tends to expand fuher during cell division. So, in succesive generations the expanded repeat increases and the manifestations of disease may worsen or to be observed at an earlier age; this phenomenon is referred to as anticipation.