This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Prion disease is cuased by 
Select and explain. 
A. Misfolding of proteins, B. Denaturation of protein, C. Reduced formation of proteins, D. Excess formation of proteins
A: Misfolding of proteins
Answer: A: Misfolding of proteins 
Explanation: None