This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Thalassemia, Subject name: Medicine
Which of the following is a quantitative defect in globin synthesis- 
Select and explain. 
A. Thalassemia, B. Sickle cell hemoglobinopathy, C. G6PD deficiency, D. Diamond-Black fan syndrome
A: Thalassemia
Answer: A: Thalassemia 
Explanation: Ans. is 'a' i.e., Thalassemiao Thalassemia is defined as a Quantitative defect in synthesis of structurally normal elobin chains.Sickle Cell Disease represents a qualitative defect in synthesis of globin chains (Structurally abnormal globin chains).# G6PD Deficiency and Diamond-Blackfan Syndrome (Pure Red Cell Aplasia) are not associated with quanitative or qualitative defects in globin chain synthesis