This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
A female patient presented with a firm mass of 2 x 2 cms in the upper outer quadrant of the breast. She gives a family history of ovarian carcinoma. The investigation that needs to be done to assess for mutation is : 
Select and explain. 
A. p53, B. BRCA-2, C. Her 2/Neu gene, D. C-myc gene
B: BRCA-2
Answer: B: BRCA-2 
Explanation: Ans. is 'b' BRCA 2 "In women with hereditary breast - ovarian cancer, two susceptibility loci have been identified:BRCA -1 - located on chromosome 17 andBRCA - 2 - located on chromosome 13" - Harrison, 15/e, p620