This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
Hirschsprung's disease is 
Select and explain. 
A. Is inherited in an Autosomal recessive fashion, B. Is due to unopposed parasympathetic activity in the affected segment of the bowel, C. Has an equal incidence in girls and boys, D. Is seen more frequently in children with Down's syndrome than in the general population
D: Is seen more frequently in children with Down's syndrome than in the general population
Answer: D: Is seen more frequently in children with Down's syndrome than in the general population 
Explanation: Is seen more frequently in children with Down's syndrome than in the general population. polygenic inheritance, male>female. Increase in sympathetic activity is due to absence of parasympathetic ganglions in the plexi of Auerbach and Meissner.