This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Most common cause of hereditary spherocytosis: 
Select and explain. 
A. Spectrin, B. Glycophorin, C. Ankyrin, D. Band 4
C: Ankyrin
Answer: C: Ankyrin 
Explanation: Most common cause of hereditary spherocytosis is ankyrin gene mutation. Ankyrin is the principal binding site for spectrin on the red cell membrane. Mutations of alpha-spectrin are associated with recessive forms of HS, whereas mutations of beta-spectrin occur in families with autosomal dominant forms of HS.