This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Resistance to Zidovudine develops due to 
Select and explain. 
A. Mutation at reverse transcriptase, B. Increased efflux of the drug from inside the cell, C. Increased metabolism of drug, D. Decreased Zidovudine 5 triphosphate formation
A: Mutation at reverse transcriptase
Answer: A: Mutation at reverse transcriptase 
Explanation: Zidovudine is a nucleoside reverse transcriptase inhibitors which is a viral enzyme .HIV undergoes mutations in this enzyme to become resistant to NIs Refer :KDT 6/e p770