This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Which of the following is not an insulin analogue? 
Select and explain. 
A. Insulin glargine, B. Insulin lispro, C. Actrapid, D. Insulin aspart
C: Actrapid
Answer: C: Actrapid 
Explanation: Ans. (C) Actrapid(Ref: KDT 8/e p285)Actrapid (regular insulin) and monotard (Lente-insulin) are unmodified insulins with same amino acid squence as natural insulinLispro, aspart, glulisine and glargine are insulin analogues in which slightly different amino acid sequence is present to modify pharmacokinetics.