This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following statements is not true of local anesthetics? 
Select and explain. 
A. The local anesthetic is required in the unionized form for penetrating the neuronal membrane, B. The local anesthetic approaches its receptor only from the intraneuronal face of the Na+ channel, C. The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state, D. The local anesthetic combines with its receptor in the ionized cationic form
C: The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state
Answer: C: The local anesthetic binds to its receptor mainly when the Na+ channel is in the resting state 
Explanation: None