This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
E6, E7 genes of which virus are implicated in oncogenesis ? 
Select and explain. 
A. EBV, B. CMV, C. HTLV- 1, D. HPV
D: HPV
Answer: D: HPV 
Explanation: Ans. is 'd' i.e., HPV HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia. Products of E-genes (E6, E7) are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively.