This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glomerular Diseases, Subject name: Medicine
Antibody in Goodpasture syndrome: 
Select and explain. 
A. Lupus anticoagulant, B. Anti-GBM antibody, C. Anti-Ro antibody, D. Anti- mitochondrial antibody
B: Anti-GBM antibody
Answer: B: Anti-GBM antibody 
Explanation: Ans. (b) Anti GBM antibodyRef.: Harrison 18th edition, Chapter 283* Patients who develop autoantibodies directed against glomerular basement antigens frequently develop a glomerulonephritis termed antiglomerular basement membrane (anti-GBM) disease. When they present with lung hemorrhage and glomerulonephritis, they have a pulmonary-renal syndrome called Goodpasture's syndrome.* Goods syndrome is a Thymoma with immunodeficiency* It is a cause of combined B and T cell immunodeficiency in adults.* The clinical characteristics of Goods syndrome are increased susceptibility to bacterial infections with encapsulated organisms and opportunistic viral and fungal infections.* The most consistent immunological abnormalities are hypo-gammaglobulinaemia and reduced or absent B cells.