This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Medicine
Primary Hyperaldosteronism can be diagnosed by all of the following criteria, except: 
Select and explain. 
A. Diastolic Hypeension without edema, B. Hyperaldosteronism which is not supressed by volume expansion, C. Low Plasma Renin Activity, D. Metabolic Acidosis
D: Metabolic Acidosis
Answer: D: Metabolic Acidosis 
Explanation: Class,Triad of Biochemical Criteria for diagnosis of Primary Hyperaldoteronism Hypokalemia with inappropriate kaliuresis (Metabolic alkalosis) Suppressed plasma renin activity Elevated Aldosterone levels that do not fall appropriately in response to volume expansion or sodium load. REF: Harrison book of internal medicine 21ST EDITION