This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
Spironolactone should not be given with 
Select and explain. 
A. Chlohiazide, B. Beta blockers, C. ACE inhibitors, D. Amlodipine
C: ACE inhibitors
Answer: C: ACE inhibitors 
Explanation: Sprinolanctone is a potassium sparing diurectic It doesn't excrete potassium - increasing potassium levels in the blood ACE IN. also increases potassium levels in the blood Hence the combination is contraindicated Ref: KD Tripathi 8th ed