This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
The drug which can be considered as an alternative for splenectomy in severe autoimmune hemolytic anemia is: 
Select and explain. 
A. Adalimubab, B. Eculizumab, C. Rituximab, D. IV immunoglobulin
C: Rituximab
Answer: C: Rituximab 
Explanation: Rituximab is effective in more than 80% of patients with severe autoimmune hemolytic anemia not responding to steroids. Ref: Harrison's principles of internal medicine, 18th edition ; Page :882.