This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
A 40 years old patient with liver dysfunction is scheduled for a surgical procedure. Lorazepam can be used for pre-anaesthetic medication in this patient without concern for excessive CNS depression because the drug is: 
Select and explain. 
A. Selective anxiolytic like buspirone, B. Conjugated directly, C. Reversible by administration of naloxone, D. Forming several active metabolites
B: Conjugated directly
Answer: B: Conjugated directly 
Explanation: (Ref: Katzung 6/e p450) Lorazepam and oxazepam are the benzodiazepines which are excreted from the body by glucuronide conjugation without phase 1 metabolism in the liver. So these can be used safely in hepatic dysfunction.