This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
The immediate type of hypersensitivity in which histamine does not play a major role is: 
Select and explain. 
A. Urticaria, B. Asthma, C. Anaphylaxis, D. Arthus reaction
D: Arthus reaction
Answer: D: Arthus reaction 
Explanation: None