This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
Which diuretic can be used in treatment of hypercalcemia? 
Select and explain. 
A. Furosemide, B. Spironolactone, C. Hydrochlorothiazide, D. Mannitol
A: Furosemide
Answer: A: Furosemide 
Explanation: Loop diuretics: Thiazide diuretics: Act on Na+K+2Cl- sympoer acts on ascending limb of loop of Henle. Includes- furosemide, torsemide, bumetanide High ceiling diuretics Loop looses calcium - therefore used in hypercalcemia Inhibits Na-Cl- sympoer acts on distal tubule Includes- chlohiazide,indapamide Decreases Na+, K+ , Mg2+, H+ Increases glucose, uric acid, lipid Increase in calcium - used in osteoporosis