This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2019, Subject name: Pathology
Caspase involved in activation of IL_1 is which of the following? 
Select and explain. 
A. Caspase 1, B. Caspase 3, C. Caspase 5, D. Caspase 8
A: Caspase 1
Answer: A: Caspase 1 
Explanation: Pyroptosis :- Example of process in which injury is initiated because of exposure to microbes. Whenever there is exposure to microbes there is activation of enzyme caspase 1 and caspase 11. Caspase 1 conve inactive form of IL 1 to active form of IL1. As IL1 has central action, it enters CNS and results in development of fever. Caspase-1 along with closely related caspase-11 also cause death of the infected cell. -Caspase 3, a typical executioner caspase that cleaves DNA and other substrates to cause cell death.