This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Disulfiraim and acamprosate are used for: 
Select and explain. 
A. Alcohol abstinence, B. Cocaine abuse, C. Opium poisoning, D. Atropine over dose
A: Alcohol abstinence
Answer: A: Alcohol abstinence 
Explanation: Disulfiram inhibits the enzyme aldehyde dehydrogenase probably after conversion into active metabolite .When alcohol is ingested after taking disulfiram the concentration of acetaldehyde in tissue & blood rises & number of highly distressing symptoms produced. Disulfiram aversion therapy is indicated in abstinent subjects. Ref KD Tripathi 8th ed.