This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Systemic Bacteriology (Gram Positive Bacilli, Gram Negative Bacilli), Subject name: Microbiology
Main cytokine involved in erythema nodosum leprosum reaction is 
Select and explain. 
A. IL 2, B. Interferon gamma, C. Tumour necrosis factor alpha, D. Macrophage colony stimulating factor
C: Tumour necrosis factor alpha
Answer: C: Tumour necrosis factor alpha 
Explanation: Erythema nodosum leprosum rection is type II lepra rection .In this modules over skin are seen This is a type III hypersensitivity reaction . Main cytokine involve is TNF -alpha DOC - gluco-coicoids