This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Bisphosphonates act by 
Select and explain. 
A. Increasing the osteoid formation, B. Increasing the mineralization of osteoid, C. Decreasing the osteoclast mediated resorption of bone, D. Decreasing the parathyroid hormone secretion
C: Decreasing the osteoclast mediated resorption of bone
Answer: C: Decreasing the osteoclast mediated resorption of bone 
Explanation: Bisphosphonates (BPNs) are analogues of pyrophosphate: carbon atom replacing oxygen in the P-0-P skeleton. They inhibit bone resorption by inhibiting osteoclast function- useful to prevent osteoporosis in addition to metabolic bone diseases and hypercalcaemia. (REF.Essentials of Pharmacology TD TRIPATHI 6th EDITION page no 333)