This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The class of antibodies that plays an important role in type I hypersensitivity reactions is _____. 
Select and explain. 
A. IgA, B. IgD, C. IgE, D. IgG
C: IgE
Answer: C: IgE 
Explanation: Although IgE is the least prevalent immunoglobulin in the body, it is the major antibody mediator of type I hypersensitivity reactions. These reactions are caused primarily by prior sensitization and the accumulation of IgE to a specific allergen.