This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Which one of the following is detected by the antigen detection test used for the diagnosis of P. falciparum malaria - 
Select and explain. 
A. Circum-sporozoite protein, B. Merozoite surface antigen, C. Histidine-Rich-Protein I (HRP-I), D. Histidine-Rich-Protein II (HRP-II)
D: Histidine-Rich-Protein II (HRP-II)
Answer: D: Histidine-Rich-Protein II (HRP-II) 
Explanation: Antigen detection tests [Rapid diagnostic tests (RDTs) or Immunochromatographic tests (ICTs)

Rapid and simple but less sensitive, costly and may give false +ve in RA factor +ve cases
pLDH and Aldolase: Common to all Plasmodium species
HRP-2 Ag detection: Specific for P.falciparum