This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Thyroid Tumor, Subject name: Pathology
All of the following are true regarding thyroid adenoma, except: 
Select and explain. 
A. Solitary, spherical and well encapsulated lesion, B. Uniform-appearing, colloid-containing follicles, C. Cystic change, calcification and Huhle cell change, D. Vascular invasion is commonly seen
D: Vascular invasion is commonly seen
Answer: D: Vascular invasion is commonly seen 
Explanation: THYROID FOLLICULAR ADENOMA: Most common benign tumor of thyroid caused d/t G-protein coupled receptor mutation. Typical thyroid adenoma is a solitary, spherical, encapsulated lesion that is demarcated from surrounding thyroid parenchyma by a well-defined, intact capsule. Hence, vascular invasion is not seen in this tumors. Microscopically, constituent cells often form uniform appearing follicles that contain colloid. Follicular growth pattern is usually quite distinct from adjacent non-neoplastic thyroid. Areas of hemorrhage, fibrosis, calcification & cystic change, similar to those encountered in multinodular goiters, are common in follicular adenomas, paicularly in larger lesions.