This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Skin
Female presents with history of color change from pallor to cyanosis on exposure to cold in fingers. This condition is mostly associated with? 
Select and explain. 
A. Scleroderma, B. Leukemia, C. Lung infections, D. Hepatosplenomegaly
A: Scleroderma
Answer: A: Scleroderma 
Explanation: A. i.e. Scleroderma Raynaud's phenomenon (i.e. cold/vibration/emotional stress-exposure Vt pallor --> cynosis & finally erythemaQ of digits, ear & tip of nose) is almost always present (along with skin sclerosis) and is often earliest featureQ of Systemic sclerosis (Scleroderm). It may precede extensive skin & internal organ involvement by week-months (in diffuse SS) to years (in limited cutaneous SS).