This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
Which of the following statement is not true about NSAIDs 
Select and explain. 
A. Acetylsalicylic acid is an Irreversible inhibitors of Cox enzyme acetylsalicylic acid is an Irreversible inhibitors of Cox enzyme, B. Acetylsalicylic acid reduces in Vivo synthesis of prostaglandins, C. Its clearance is independent of Plasma concentration, D. Antiplatelet effect of low dose aspirin is related to pre systemic Cox inhibition
C: Its clearance is independent of Plasma concentration
Answer: C: Its clearance is independent of Plasma concentration 
Explanation: Acetylsalicylic acid (asprin) is an Irreversible inhibition of COX enzyme. IT results in inhibition of prostaglandin and TX synthesis at low doses for (40 to 325 milligrams) it exes antiplatelet action. this drug shows saturation kinetics at high doses that is kinetics changes from first order to zero order. therefore at high doses amount of drug exeed will be constant that means clearance il is not constant. Refer kDT 6/e p185