This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Local and Regional Anesthesia, Subject name: Anaesthesia
Which of the following mixture of anesthetics is applied on skin? 
Select and explain. 
A. Lidocaine and prilocaine, B. Bupivacaine and prilocaine, C. Lidocaine and bupivacaine, D. Lidocaine and procaine
A: Lidocaine and prilocaine
Answer: A: Lidocaine and prilocaine 
Explanation: Ans is 'a' i.e. Lidocaine and prilocaine Eutectic mixture of local Anaesthetics (EMLA)* This is unique topical preparation which can anaesthetize intact skin.* It is a mixture of 2.5% lidocaine and 2.5% prilocaine.* It acts slowly and the cream must held in contact with skin for at least 1 hour.* EMLA is used : to make venepuncture painless especially in children, and for procedure like skin grafting & circumcision.* As systemic absorption of prilocaine can cause methemoglobinemia, EMLA should not be used on mucocutaneous membrane or in very small child.