This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Enzyme deficient in tyrosinemia type 1 ? 
Select and explain. 
A. Phenylalanine hydroxylase, B. Tyrosinase, C. Fumarylacetoacetate hydroxylase, D. Tyrosine transaminase
C: Fumarylacetoacetate hydroxylase
Answer: C: Fumarylacetoacetate hydroxylase 
Explanation: TyrosinemiaIt is a defect in metabolism of tyrosine. It may be of following types :-Tyrosinemia type-I (tyrosinosis/hepatorenal syndrome) :- It is due to defect in fumarylacetoacetate hydroxylase deficiency. Patients with chronic tyrosinosis are prone to develop cirrhosis and hepatic carcinoma. There is cabbage like odor in acute tyrosinosis.Tyrosinemia type - II (Richer-Hanha syndrome) :- It is due to deficiency of tyrosine transaminase (tyrosine aminotrans-ferase).Neonatal tyrosinemia : - It is due to deficiency of hydroxyphenyl pyruvate hydroxylase.