This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
During direct immunofluorescence testing of renal biopsy specimen, lumpy bumby immune deposits are seen with conjugated antibodies against: 
Select and explain. 
A. IgG, IgM, and IgA, B. GBM, C. C3 and C4, D. IgE
A: IgG, IgM, and IgA
Answer: A: IgG, IgM, and IgA 
Explanation: Direct immunofluorescence of renal biopsy specimen Direct immunofluorescence with Conjugated antibodies against IgG, IgM, and IgA to detect the presence of "lumpy-bumpy" immune deposits and Linear IgG or IgA antibodies bound to GBM antibodies against trapped complement proteins (C3 and C4). Ref: Harrison-18, P-2339.