This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetic and genetic disorders, Subject name: Pediatrics
The karyotope in testicular feminising syndrome is ? 
Select and explain. 
A. XX, B. XY, C. XXY, D. XXXY
B: XY
Answer: B: XY 
Explanation: Testicular feminising syndrome or androgen insensitivity syndrome is an X linked disorder of androgen action. It is characterised by resistance to androgens. Its karyotype is 46,XY. Pathology Affected individuals are genotypically male with a 46XY karyotype but with a female phenotype ( Genetics Thought to carry an X linked recessive inheritance 3 where multiple mutations in the androgen receptor (AR) gene has been localized to the long arm of the X chromosome (i.e. Xq11-13). Reference: Ghai TB of pediatrics 8th edition,pg 538 table 17.32