This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anesthesia, Subject name: Pharmacology
True statement about sevoflurane is: 
Select and explain. 
A. It is nephrotoxic at high doses, B. It has maximum risk of causing convulsions, C. It is cardiostable, D. It can cause fulminant hepatitis
A: It is nephrotoxic at high doses
Answer: A: It is nephrotoxic at high doses 
Explanation: Sevoflurane is chemically unstable and is degraded by carbon dioxide absorbers to a metabolite taut can cause nephrotoxicity. Sevoflurane undergoes bio transformation in the liver to release fluoride ions which can cause nephrotoxicity. Sevoflurane doesn't cause fulminating hepatitis nor convulsions. From padmaja 4th edition Page no 193