This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Liver and Biliary System, Subject name: Pediatrics
Conj ugated hyperbilirubinemia - 
Select and explain. 
A. Dubin Johnson syndrome, B. Criggler najjar syndrome, C. Breast mi lk jandice, D. Gilbert syndrome
A: Dubin Johnson syndrome
Answer: A: Dubin Johnson syndrome 
Explanation: Ans. is 'a' i.e., Dubin johnson syndrome o Breast milk jaundice-Decrease bilirubin uptake across hepathocyte membrane.Entero-hepatic recirculation.Leads to indirect hyperbilirubinemia.o Crigler najjar & Gilbert syndrome (deficiency of glucuronyl transferase) <Type I - Complete deficiency Type II - Partial deficiencyy Decrease conjugation leads to Indirect hyperbilirubinemia.Defect in hepatocyte secretion of conjugated bilirubin, a Leads to direct hyperbilirubinemia.