This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
Preferred drug for the treatment of a 48 year old man with uncomplicated grade 2 hypeension without any associated co-morbidity is 
Select and explain. 
A. Chlohalidone, B. Triamterene, C. Spironolactone, D. Furosemide
A: Chlohalidone
Answer: A: Chlohalidone 
Explanation: According to ACC Guidelines and JNC 8 Guidelines - DOC for hypeension is Thiazides (preferred diuretic). The other first line drugs for hypeension are- - ACE Inhibitors - Angiotensin receptor blockers - Calcium channel blockers Triamterene and Spironolactone are K+ Sparing Diuretics - mainly used along with other diuretics to prevent hypokalemia. Furosemide - is a loop diuretic - used for conditions like congestive hea failure.