This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
Vitamin E toxicity causes 
Select and explain. 
A. Reduce platelet aggregation, B. Polyneuropathy, C. Spinocerebellar ataxia, D. Retrolental fibroplasia
A: Reduce platelet aggregation
Answer: A: Reduce platelet aggregation 
Explanation: (A) Reduce platelet aggregation # Vitamin E Toxicity:> It is likely that patients with vitamin E toxicity have been using vitamin E supplements; obtain the dose and duration of vitamin E usage. Assess concurrent use of anticoagulants or aspirin.> A nutritional assessment for vitamin K deficiency is useful in patients who present with bleeding or an elevated PT.> Effects of acute vitamin E toxicity include the following: Nausea; Gastric distress; Abdominal cramps; Diarrhea; Headache; Fatigue.> Easy bruising and bleeding - Prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT).> Inhibition of platelet aggregation: Diplopia - At dosages as low as 300 IU; Muscle weakness; Creatinuria.> Chronic toxicity effects include all of the above, suppression of other antioxidants, and increased risk of hemorrhagic stroke.