This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
All are true about nephrnophthisis except 
Select and explain. 
A. Interstitial fibrosis, B. Coical tubular hyperophy, C. Cysts in the medulla, D. 20% cases are non-familial
B: Coical tubular hyperophy
Answer: B: Coical tubular hyperophy 
Explanation: Coical tubulointerstitial damage occurs in nephrnophthisis nephrnophthisis (uremic medullary cystic diseases complex) it is a group of progressive renal disorders that usually have onset in childhood . 4 variants of diseases are; Sporadic /non familial Familial juvenile nephrnophthisis Renal retinal dysplasia Adult onset medullary cystic disease Affected children present first with polyuria and pilydipsia which reflects a marked tubular defect in concentrating ability Refer robbins 8/959