This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Incomplete closure of ectodermal cleft is know to cause 
Select and explain. 
A. Retinal detachment, B. Iridodonesis, C. Retinoblastoma, D. Coloboma of iris and retina
D: Coloboma of iris and retina
Answer: D: Coloboma of iris and retina 
Explanation: Inderbir Singh&;s Human embryology Tenth edition Pg 364 Failure of the choroidal fissure to obliterate completely may lead to deficiencies( coloboma)of various layers of eyeball including iris ciliary body and choroid