This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Anaplastic cells often display the following morphologic features except  --------. 
Select and explain. 
A. Nuclear-to-cytoplasmic ratio 1:1, B. Retention of polarity, C. Formation of tumor giant cells, D. Quadripolar mitotic figures
B: Retention of polarity
Answer: B: Retention of polarity 
Explanation: Anaplastic cells often display the following morphologic features:

Pleomorphism (i.e., variation in size and shape).
Nuclear abnormalities, consisting of extreme hyperchromatism  (dark-staining), variation in nuclear size and shape, or unusually prominent single or multiple nucleoli. Enlargement of nuclei may  result in an increased nuclear-to-cytoplasmic ratio that approaches 1:1 instead of the normal 1:4 or 1:6. Nucleoli may attain astounding  sizes, sometimes approaching the diameter of normal lymphocytes.
Tumor giant cells may be formed. 
Atypical  mitoses, which may be numerous. Anarchic multiple spindles may produce tripolar or quadripolar mitotic figures. 
Loss of polarity.

Reference-Robbins BASIC PATHOLOGY 10th edition pg-193