This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
Spherocytosis in peripheral blood smear is seen in which of the following? 
Select and explain. 
A. Post-transfusion, B. Hereditary spherocytosis, C. Hemolytic disease of newborn, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: Spherocytosis is seen in Hereditary spherocytosis Autoimmune hemolytic anemia Hemolytic disease of newborn Post-transfusion Heinz body hemolytic anemia (G6PD deficiency, etc.) Water-dilution hemolysis (IV water infusion or drowning (fresh water)) Fragmentation hemolysis (Burns, mechanical trauma) Spherocytes represent red cells, with the most decreased surface area:volume ratio seen in hereditary spherocytosis, immune hemolytic anemia, stored blood, Heinz body hemolytic anemia, and caused by cell fragmentation.