This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Biochemistry
Insulin acts on glucose metabolism by 
Select and explain. 
A. | permeability of glucose across cell membrane, B. | permeability of glucose across cell membrane against glucose gradient, C. | permeability of renal cells, D. | glucose transpo to brain
B: | permeability of glucose across cell membrane against glucose gradient
Answer: B: | permeability of glucose across cell membrane against glucose gradient 
Explanation: Insulin signals the cells of insulin-sensitive peripheral tissues, primarily skeletal muscle, to increase their uptake of glucose.Secondly, insulin acts on the liver to promote glycogenesis.Finally, insulin simultaneously inhibits glucagon secretion from pancreatic a-cells, thus signalling the liver to stop producing glucose glycogenolysis and gluconeogenesis Ref: DM Vasudevan, 7th edition, page no: 165, 318, 323