This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Pharmacology
The recently approved antiepileptic drug lacosamide acts by: 
Select and explain. 
A. Inhibiting synaptic vesicular protein, B. Inhibing CRMP protine, C. Inhibing GABA metabolism, D. Inhibing glutamate release
B: Inhibing CRMP protine
Answer: B: Inhibing CRMP protine 
Explanation: (Ref: Katzung, 14th ed. pg. 417)* CRMP is Collapsing Response Mediator Protein, which causes neuronal excitotoxicity by releasing BDNF (Brain Derived Neurotropic Factor).* The drug Lacosamide acts by inhibiting CRMP protein, thereby causing protective action against neuronal excitotoxicity.