This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All of the following statements about nateglinide are true except ? 
Select and explain. 
A. Decreases postprandial hyperglycemia, B. Hypoglycemia is less common than with sulfonylureas, C. It decreases insulin resistance, D. It acts by releasing insulin
C: It decreases insulin resistance
Answer: C: It decreases insulin resistance 
Explanation: Sulfonylureas, nateglinide and repaglinide act by inhibiting ATP sensitive K channels and thus resulting in the release of insulin.
Like insulin, all of these drugs can cause hypoglycemia. However, nateglinide therapy produces fewer episodes of hypoglycemia as compared to other oral insulin secretagogue.
Nateglinide and repaglinide are short-acting and thus can reduce post-prandial hyperglycemia.