This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Histological appearance of scleroderma include all except 
Select and explain. 
A. Extensive fibrosis of upper 1/3 of the dermis, B. Decreased adnexal structure., C. Homogenization of collagen, D. Increased dermis thickness
A: Extensive fibrosis of upper 1/3 of the dermis
Answer: A: Extensive fibrosis of upper 1/3 of the dermis 
Explanation: Ans: A Extensive fibrosis of upper 1/3 of the dermis Mucin deposition is a feature of metabolic diseases like pretibial myxedema, scleroderma and lichen myxedematosis. Microscopy appearance of scleroderma- Thinning of epidermis, extensive fibrosis of lower 2/3 of dermis, replacement of subcutaneous fat, homogenization of collagen and decreased adnexal structure.