This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Mutation seen in malignant melanoma 
Select and explain. 
A. P53, B. CDKN2A, C. RET, D. Rb
B: CDKN2A
Answer: B: CDKN2A 
Explanation: Germline mutations in CDKN2A gene are found in about 40% of familial malignant melanoma cases.