This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following antihypeensive drugs should not be used in a patient on Lithium in order to prevent Lithium Toxicity. 
Select and explain. 
A. Clonidine, B. Beta blockers, C. Calcium Channel Blockers, D. Diuretics
D: Diuretics
Answer: D: Diuretics 
Explanation: Ans is 'd' i.e. Diuretics Interactions of lithium 1. Diuretics (thiazide, furosemide) by causing Na+ loss promote proximal tubular reabsorption of Na+ as well as Li - Plasma level of lithium rises. Tetracyclines, NSAIDs and ACE inhibitors cause lithium retention. Lithium tends to enhance insulin/sulphonylurea induced hypoglycemia (lithium has insulin like action on glucose metabolism). Lithium inhibits the action of ADH on distal tubules --> causes nephrogenic DI. Lithium reduce thyroxine synthesis by interfering iodination of tyrosine.