This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which is true about Multiple Myeloma? 
Select and explain. 
A. M spike increase, B. Direct plasma cell deposition in glomerular capillaries leads to kidney damage, C. IL 8 is a marker for bone lesions, D. Invariablly increase in alkaline Phosphatase
A: M spike increase
Answer: A: M spike increase 
Explanation: None