This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
Which of the following liver enzymes is predominantly mitochondrial? 
Select and explain. 
A. SGOT (AST), B. SGPT (ALT), C. GGT, D. 5' Nucleotidase
A: SGOT (AST)
Answer: A: SGOT (AST) 
Explanation: In old literature, it was called as serum glutamate oxaloacetate transaminase (SGOT). AST needs pyridoxal phosphate (vitamin B6) as co-enzyme. Normal serum level of AST ranges from 8 to 20 U/L. It is a marker of liver injury and shows moderate to the drastic increase in parenchymal liver diseases like hepatitis and malignancies of the liver.Ref: DM Vasudevan, Page no: 269