This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Pathology
Brain edema is associated with 
Select and explain. 
A. Increase in ECF volume, B. Increase brain water content, C. Increase volume in interstitial space, D. None of the above
A: Increase in ECF volume
Answer: A: Increase in ECF volume 
Explanation: (A) Increase in ECF volume # Vasogenic edema occurs when the integrity of the normal blood-brain barrier is disrupted. With increased vascular permeability, fluid shifts from the vascular compartment into intercellular spaces of the brain (ECF compartment). Vasogenic edema can be either localized-because of abnormal permeability of vessels adjacent to inflammation or tumors-or generalized.> Cytotoxic edema implies an increase in intracellular fluid secondary to neuronal, glial, or endothelial cell membrane injury, as might be encountered in an individual with a generalized hypoxic/ischemic insult or with exposure to some toxins.