This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
All of the following genes may be involved in development of carcinoma of colon Except 
Select and explain. 
A. APC, B. Beta-Catenin, C. K-ras, D. Mismatch Repair Genes
B: Beta-Catenin
Answer: B: Beta-Catenin 
Explanation: .Detection of mutations in congenital conditions like von - Hippel - Lindau disease (vHL gene); haemochromatosis (HFE gene); colorectal carcinoma(APC gene).Familial gastric cancer in associated with mutation of e-cadherin gene (90% risk). It causes hereditary diffuse gastric cancer. Relatives of such family show mutation of this gene. Whether prophylactic total gastrectomy is needed or not in these high risk individuals is a debate. ref:SRB&;s manual of surgery ,ed 3,pg no 777