This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
Which of the following is characterized by denervation atrophy of the muscles? 
Select and explain. 
A. Carnitine palmityl transferase deficiency, B. McArdle disease, C. Pompe disease, D. Werdnig-Hoffman disease
D: Werdnig-Hoffman disease
Answer: D: Werdnig-Hoffman disease 
Explanation: Werdnig-Hoffman disease is an autosomal recessive, congenital, muscular hypotonia characterized by marked neurogenic muscular atrophy. This condition is also called "infantile spinal muscular atrophy" and is primarily due to the destruction of the anterior horn cells in the spinal cord. All other diseases listed are metabolic myopathies, representing inborn errors of carbohydrate metabolism (McArdle and Pompe disease), lipid metabolism (carnitine palmityl transferase deficiency), and purine metabolism (myoadenylate deaminase deficiency). Ref - Harrison's internal medicine 20e pg 3147