This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
Which of the following drug can be accumulated in foetus in very significant amount if given to pregnant mother? 
Select and explain. 
A. Thiopentone, B. Propofol, C. Midazolam, D. Lignocaine
D: Lignocaine
Answer: D: Lignocaine 
Explanation: Local anaesthetic and opioids are bases. Once they reach the fetus they become nonionized (due to highly acidic pH) and can not come back to maternal circulation leading to toxic accumulations in fetus.