This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
Neurological worsening with anemia what is the treatment to be given: 
Select and explain. 
A. Iron, B. Folic Acid alone, C. Folic acid along with Hydroxycobalamin, D. Vitamin B1 alone
C: Folic acid along with Hydroxycobalamin
Answer: C: Folic acid along with Hydroxycobalamin 
Explanation: Vitamin deficiency Manifestation In folate megaloblastic anemia B12 Megaloblastic anemia & neurological manifestations occur. Clinical manifestations of B12 deficiency: Haematological: Megaloblastic anemia, Hypersegmentation of neutrophils. Neurological: Demyelination in peripheral nerves and spinal cord Megaloblastic anemia is due to secondary deficiency of folate (folate trap in B12 deficiency) Peripheral neuropathy is due to accumulation of L-methyl malonic acid.