This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacteria, Subject name: Microbiology
Toxic shock syndrome caused by Staphylococcus is due to: 
Select and explain. 
A. Hemolysins, B. Super antigens, C. Coagulase, D. Hyaiuronidase
B: Super antigens
Answer: B: Super antigens 
Explanation: Ans: B (Super antigens) Ref: Ananthnarayan R, Paniker CKJ. Textbook of Microbiology. 8th Edition. Hyderabad: Universities Press; 2009. Pg. 198-9.Explanation:Microbial super antigens such as Streptococcal protein A and Staphylococcal enterotoxin can stimulate the broad range T & B cells irrespective of their antigenic specificity.Toxic Shock SyndromeTSST is the cause of toxic shock syndrome (TSS). TSST is a superantigen.Superantigens stimulate T cells non- specifically without normal antigenic recognitionUp to one in five T cells be activated, whereas only 1 in 10,000 are stimulated during a usual antigen presentation.Cytokines are released in large amounts, causing the symptoms of TSS.Superantigens bind directly to class II major histocompatibility complexes of antigen-presenting cells outside the conventional antigen-binding grove.