This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Mechanism which is responsible for gentamicin ototoxicity is: 
Select and explain. 
A. Accumulation of drug metabolites., B. Direct hair cell toxicity., C. Inhibition of Na-K ATPase channels., D. All of the above.
B: Direct hair cell toxicity.
Answer: B: Direct hair cell toxicity. 
Explanation: Ototoxicity involves progressive and irreversible damage to, and eventually destruction of, the sensory cells in the cochlea and vestibular organ of the ear.