This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
The enzyme is the rate limiting enzyme in cholesterol synthesis is: 
Select and explain. 
A. HMG CoA synthetase, B. HMG CoA reductase, C. HMG CoA lyase, D. Catalase
B: HMG CoA reductase
Answer: B: HMG CoA reductase 
Explanation: Ans. (b) HMG CoA reductaseRef: Harper's Biochemistry, 30th ed. pg. 267* HMG CoA reductase is the rate limiting ezyme in cholesterol synthesis.* HMG CoA Synthetase is involved in the formation of ketone bodies while HMG CoA lyase is involved also in the ketogenesis and also in the processing of leucine.* Catalase on the other hand is an oxidoreductase which is involved in the conversion of hydrogen peroxide to water and oxygen.