This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Pathology
Which of the following is the commonest genetic mutation in a 50 year old obese female presenting with postmenopausal bleeding and diagnosed with endometrial cancer? 
Select and explain. 
A. P53, B. PTEN, C. CHD4, D. Beta catenin
B: PTEN
Answer: B: PTEN 
Explanation: 50 year old obese female with endometrial cancer most likely to be type I Endometrial cancer rather than type II which happens in elderly female >65yrs. Type I Type II - 55-56 yo - Endometroid - Hyperplasia - Indolent - PTEN Genetic Mutation - 65-75 yo. - Clear cell serous - Atrophy - Aggressive - P 53 gene mutation