This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Which substance gets accumulated in abnormal amounts in Alkaptonuria 
Select and explain. 
A. Acetoacetate, B. Oxalate, C. Homogentisate, D. Phenylacetic acid
C: Homogentisate
Answer: C: Homogentisate 
Explanation: Alkaptonuria:

Homogentisate oxidase deficiecy
Accumulation of Homogentisic acid.
Ochronosis: Deposition of alkaptone bodies in cartilages leading to pigmentation.