This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
Most common cause of mobius syndrome is use of which of the following drug in pregnancy? 
Select and explain. 
A. Misoprostol, B. Thalidomide, C. Methotrexate, D. Dinoprostone
A: Misoprostol
Answer: A: Misoprostol 
Explanation: An extremely rare congenital neurological disorder which is characterized by facial paralysis and the inability to move the eyes from side to side. Most people with Mobius syndrome are born with complete facial paralysis and cannot close their eyes or form facial expressions. Ref: KD Tripathi 8th ed