This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Antihypeensives act by all of the following mechanism except: March 2012 
Select and explain. 
A. Na. ATPase inhibition, B. Alpha adrenergic blockade, C. Beta adrenergic blockade, D. Potassium channel opener
A: Na. ATPase inhibition
Answer: A: Na. ATPase inhibition 
Explanation: Ans: A i.e. Na+ K+ ATPase Antihypeensives and mechanism of action Digitalis increases increase force of cardiac contraction (cardiac inotropic) by selectively binding to extracellular face of the membrane associated Na' K' ATPase of myocardial fibres and inhibits it. Digitalis is used in congestive hea failure and cardiac arrhythmias. Prazosin, terazosin, doxazosin, phentolamine and phenoxybenzamine are alpha adrenergic blocking anti-hypeensive drugs. Propranolol, metoprolol, atenolol etc. are some of the beta adrenergic blocking anti-hypeensive drugs Minoxidil and diazoxide are potassium channel openers which were used earlier in severe hypeension and hypeensive emergencies.