This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
A person was on chemotherapy for 2 week for some mediastinal tumour. Now he develops high frequency hearing loss. Most probable cause of this condition is use of: 
Select and explain. 
A. Cispiatin, B. Etoposite, C. Doxorubicin, D. Methotrexate
A: Cispiatin
Answer: A: Cispiatin 
Explanation: Ans: A (Cisplatin) OTOTOXIC DRUGS P.LDhingra 6th/33-34Various drugs & chemical can damage the in ner ear & cause sensorineural hearing loss, tinnitus & sometimes vertigoCytotoxic drugs causing hearing loss are- nitrogen mustardfmechlorethamine), cisplatin & carboplatin"Cisplatin: Important toxicities are- renal impairment & emetogenic potential.Tinnitus, deafness, sensory neuropathy & byperuricaemia are other problem"- K.D.T 7th/861'Carboplatin: Nephrotoxicity, ototoxicity & neurotoxicity are low as compared to cisplatin"- K.D.T 7th/861Table Dhingra Ototoxic drugsA. Aminoglycoside antibiotisE. AnalgesicsStreptomycinDihydrostreptomvcinGentamicinTobramycinNeomycinKanamycinAmikacinNetilmycinSisomycinSalicylatesIndomethacinPhenylbutazoneIbuprofenF. ChemicalsAlcoholTobaccoMarijuanaCarbon monoxidePoisoningB. DiureticsFurosemideEthacrynic acidBumetanideG. MiscellaneousErythromycinAmpicillinPropranololPropylthiouracilDeferoxamineC. AntimalarialsQuinineChlonoquineHydroxychloroquineD, Cytotoxic drugsNitrogen mustard (Mechlorethamine)CisplatinCarboplatin