This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pathology
Which disease is caused by anti - phospholipase 2 antibody: 
Select and explain. 
A. MPGN, B. Membrabous glomerulopathy, C. FSGN, D. Minimal Change Disease
B: Membrabous glomerulopathy
Answer: B: Membrabous glomerulopathy 
Explanation: Membranous glomerulopathy:- MC nephrotic syndrome in elderly patient. Subepithelial Immune complex deposition on IF Spike and dome appearance on EM Cause by Anti phospholipase 2 receptor Antibody FSGS:- MC nephrotic syndrome in adult No immune complex deposition, -ve Immunofluorescent Effacement of foot processon EM. Minimal Changes:- MC nephrotic syndrome is children No Immune complex deposition, -ve IF Effacement of foot process on EM. MPGN :- Nephrotic syndrome involving mesangial and increase proliferation of capillary loop. Train tract appearance on H/E due to thick glomerular basement membrane. Immune complex deposition (Granular IF)