This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
Erythroblastosis-foetalis is a example of which type of hypersensitivity reaction: 
Select and explain. 
A. Type I, B. Type II, C. Type III, D. Type IV
B: Type II
Answer: B: Type II 
Explanation: (Type II) (161 -AN7th) (201-CP)Type II reaction - The antibody is directed against an epitope that can be microbial product passiely adsorbed on to a cell or a drug or a self molecule. Both IgG and IgM antibodies are produced in type II reaction. The antibody attaches to the antigen via Fab region of Ab. As a result, Type II reaction may be complement mediated lysis of cells as occurs in Autoimmune hemolytic anemia, ABO transfusion reaction or Rh haemolytic disease.Examples1. Isoimmune reaction - such as ABO transfusion reactions Eiythroblastosis foetalis2. Autoimmune reaction - Autoimmune haemolytic anemia, agranulocytosis or thrombocytopenia.