This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
A 37-year-old immunosuppressed patient with renal failure develops sepsis. Which of the following antibiotics, if used, would require a major reduction in dosage? 
Select and explain. 
A. erythromycin, B. doxycycline, C. tobramycin, D. isoniazid (INH)
C: tobramycin
Answer: C: tobramycin 
Explanation: Amikacin and vancomycin are the other antibiotics that require dose reduction in renal failure. Newer antibiotics are often used instead of aminoglycosides to reduce the risk of renal damage.