This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Smudge cell is seen in 
Select and explain. 
A. Nodular sclerosis Hodgkin's lymphoma, B. Chronic lymphocytic leukemia, C. Lymphocyte predominant Hodgkin's lymphoma, D. Sezary syndrome
B: Chronic lymphocytic leukemia
Answer: B: Chronic lymphocytic leukemia 
Explanation: Lymphohistiocytic cells or L-H cells or popcorn cells are seen in lymphocyte predominant Hodgkin's lymphoma.
These cells are CD 45, CD 20 and epithelial membrane antigen positive. Lacunar cells are seen in nodular sclerosis Hodgkin's disease. They are positive for CD15, CD30 and PAX 5.
Smudge cells are seen in CLL.
Sezary cells are seen in Sezary syndrome.