This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
Non-competitive Inhibitors 
Select and explain. 
A. Increase Km, B. Decrease Km, C. Increase Vmax, D. Decrease Vmax
D: Decrease Vmax
Answer: D: Decrease Vmax 
Explanation: Lower V max But Do Not Affect Km