This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
S100 is a marker used in the diagnosis of 
Select and explain. 
A. Melanoma, B. Schwannoma, C. LCH, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: S100 proteins are normally present in cells derived from the neural crest (Schwann cells, and melanocytes), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes.S100 protein family are useful as markers for ceain tumors and epidermal differentiation. It can be found in melanomas, schwannomas, neurofibromas, 50% of malignant peripheral nerve sheath tumors, paraganglioma stromal cells, histiocytoma and clear cell sarcomas.