This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Mediator of fever is? 
Select and explain. 
A. IFN-γ, B. TNF-α, C. IL-10, D. IL-2
B: TNF-α
Answer: B: TNF-α 
Explanation: “IL-1 and TNF-α are the two most importantpyrogenes ”