This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Major contribution to cachexia with advanced cancer? 
Select and explain. 
A. Clathrin, B. Histamine, C. Interferon, D. Tumor-necrosis-factor (TNT)
D: Tumor-necrosis-factor (TNT)
Answer: D: Tumor-necrosis-factor (TNT) 
Explanation: Ans. is 'd' i.e., Turnor-necrosis factor (TNT) Patients with cancer commonly suffer progressive loss of body fat which is accompnied by profound weakness anorexia, and anemia. This wasting syndrome is referred to as cachexia. o TNF produced by macrophages or some tumor cells is the most impoant mediator of cachexia.