This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipid Oxidation and Synthesis, Subject name: Biochemistry
Zellweger syndrome is due to defect in- 
Select and explain. 
A. Fatty acid synthesis in cytosol, B. Fatty acid oxidation in peroxisomes, C. Fatty acid oxidation in mitochondria, D. Fatty acid oxidation in smooth ER
B: Fatty acid oxidation in peroxisomes
Answer: B: Fatty acid oxidation in peroxisomes 
Explanation: Ans. is 'b' i.e., Fatty acid oxidation in peroxisomes o Zellweger Syndrome is a rare inborn error of peroxisomal fatty acid oxidation due to absence of functional peroxisomes in all tissues. As a result, the long chain fatty acids are not oxidized in peroxisomes and accumulate in tissues particularly in brain, liver, kidney and muscle and usually result in death by age six.