This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Side effect of oral carbonic anhydrase inhibitors include ? 
Select and explain. 
A. Weight gain, B. Insomnia, C. Hyperkalemia, D. Paresthesia
D: Paresthesia
Answer: D: Paresthesia 
Explanation: Ans: D. Paresthesia[Ref KDT Vh/e p. 5g7; Clinical pharmacology 8th/e p. 71g)Adverse effects of systemic/oral carbonic anhydrase inhibitors are:CNS effects: Lethargy, drowsiness, headache, seizures, and ParesthesiasGI effects: Nausea, vomiting, diarrhea, altered taste, and anorexiaDiuretic effect : Polyuria and increased thirst; fluid and electrolyte disturbances (hypokalemia, metabolic acidosis)Worsening of liver disease : Precipitation of hepatic encephalopathy / hepatic coma and hepatic necrosisHypersensitivity reaction: In patients sensitive to sulfonamide (CAase inhibitors are sulfonamide derivatives)Hyperuricemia: Precipitation of goutBone marrow depression: Rare