This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Extended activity of ii-lactamases inactivate ? 
Select and explain. 
A. Cephalosporins-III generation, B. Macrolides, C. Quinolone, D. Aminoglycosides
A: Cephalosporins-III generation
Answer: A: Cephalosporins-III generation 
Explanation: Ans. is 'a' i.e., Cephalosporins-III generation ESBL are lactamases that mediate resistance (by hydrolyzing) to extended spectrum (third generation) cephalosporins, penicillins and monobactams (e.g. aztreonam).