This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following is not a side effect of long-term use of PPI? 
Select and explain. 
A. Hypothyroidism, B. Osteoporosis leading to hip fracture in women, C. Community acquired pneumonia, D. Clostridium difficile infection
A: Hypothyroidism
Answer: A: Hypothyroidism 
Explanation: Ans. a. Hypothyroidism