This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General surgery, Subject name: Surgery
Monckeberg&;s calcific sclerosis affects the medium-sized muscular aeries by involving 
Select and explain. 
A. Intima, B. Media, C. Adventitia, D. All of the above
B: Media
Answer: B: Media 
Explanation: Monckeberg medial sclerosis is characterized by calcification of the walls of muscular aeries, typically involving the internal elastic membrane. Persons older than age 50 are most commonly affected. The calcifications do not encroach on the vessel lumen and are usually not clinically significant.Ref: Robbins; 9th edition; Chapter 11; Blood Vessels; Page no: 490