This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
Methemoglobinemia is associated with: 
Select and explain. 
A. Aicaine, B. Prilocaine, C. Bupivacaine, D. Mepivacaine
B: Prilocaine
Answer: B: Prilocaine 
Explanation: A unique systemic side effect associated with a specific local anesthetic is the development of methemoglobinemia after the administration of large doses of prilocaine. In general, 600-mg doses are required for the development of clinically significant levels of methemoglobinemia in adults. Ref: Miller's anesthesia-7th ed, Chapter 30.