This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Symptomatic neonatal CNS involvement is most commonly seen in which group of congenital intrauterine infection - 
Select and explain. 
A. CMV and toxoplasmosis, B. Rubella and toxoplasmosis, C. Rubella and HSV, D. CMV and syphillis
C: Rubella and HSV
Answer: C: Rubella and HSV 
Explanation: Ans. is 'c' i.e., Rubella and HSV o CNS involvement is common feature from infection with all agents of TORCH group. o With most infections, patients remain asymptomatic in neonatal period and serious neurological consequences become apparent after neonatal period. o CNS manifestations that are symptomatic in neonatal period are most commonly seen in - i) HSV (76-100%) ii) Rubella (26-60%) o CMV, toxoplasma, and syphillis become symptomatic in less than 10%45% of cases.