This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Pathology
Dilated cardiomyopathy, gene altered is? 
Select and explain. 
A. Dystrophin, B. Titin, C. Sarcomere, D. Mitochondrial genes
B: Titin
Answer: B: Titin 
Explanation: Ans. (b) Titin(Ref: Robbins 9th/pg 565-566; 8th/pg 573-574)DCM is familial in at least 30% to 50% of casesAutosomal dominant inheritance is the predominant pattern;Most common- mutations in TTN, a gene that encodes titin (20% of all cases of DCM)