This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
Anemia of chronic disease is differentiated from iron deficiency anemia by the presence of- 
Select and explain. 
A. | TIBC, B. |TIBC, C. | Serum ferritin, D. | Bone marrow iron store
B: |TIBC
Answer: B: |TIBC 
Explanation: <p>In anemia of chronic diorder, a defect in transfer of iron from macrophages to developing erythroid cells in the marrow leads to reduced availability of iron for haem synthesis despite adequate iron stores ,elevating serum ferritin levels.Thus total iron binding capacity is low to normal in contrast to iron deficiency where there is reduction in aerum iron but high TIBC.</p><p>Harsh mohan textbook of pathology sixth edition pg no 302</p>