This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
Warfarin induced skin necrosis is more common in patients with 
Select and explain. 
A. Protein C deficiency, B. Sickle cell anemia, C. Factor V leiden deficiency, D. Antithrombin 3 deficiency
A: Protein C deficiency
Answer: A: Protein C deficiency 
Explanation: It is due to decreased levels of protein C. It is more likely to occur in patients with genetic deficiency of protein C. Most common side effect of warfarin:Bleeding Dermal vascular necrosis is early appearing adverse effect. Due to decreased osteocalcin synthesis Warfarin causes nasal hypoplasia and therefore contraindicated in pregnancy