This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Trans-placental spread is least associated with? 
Select and explain. 
A. HSV, B. Rubella, C. HBV, D. HIV
A: HSV
Answer: A: HSV 
Explanation: HSV infection may be acquired in utero, during the birth process, or during the neonatal period.
Intrauterine and postpartum infections occur infrequently. 
Most cases of neonatal herpes result from maternal infection and transmission, usually during passage through a contaminated infected birth canal of a mother with asymptomatic genital herpes.