This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Cizotinib is inhibitor of which receptor ? 
Select and explain. 
A. Tyrosine kinase, B. VEGF receptor, C. TNF alpha receptor, D. PDGF receptor
A: Tyrosine kinase
Answer: A: Tyrosine kinase 
Explanation: Ans. is 'a'i.e., Tyrosine kinaseRefCardio - oncology: principles, prevention and management, by puja Mehta, p. 10)CrizotinibIt is a small molecule multitargeted tyrosine kinase receptor inhibitor targeting ALK, MET, ROS1 kinases.By inhibiting ALK tyrosine kinase activity, crizotinib inhibits cell proliferation, induces Gl - S phase cell cycle arrest and apoptosis.It is approved for the first line in the management of metastatic non-small cell lung cancer with an ALK mutation.