This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
In a patient with nephrotic syndrome and hypoalbuminemia, protein binding of which drug will not be affected: 
Select and explain. 
A. Tolbutamide, B. Morphine, C. Diazepam, D. Valproate
B: Morphine
Answer: B: Morphine 
Explanation: - In the given options, only Morphine has less plasma protein binding (35%), whereas all others are highly plasma protein bound (>90%).
- In nephrotic syndrome, there will be protein loss resulting in hypoalbuminemia. So less plasma proteins.