This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
Biotin is used in the treatment of: 
Select and explain. 
A. Multiple carboxylase deficiency, B. Keto acid dehydrogenase deficiency, C. Transketolase deficiency, D. Multiple dehydrogenase deficiency
A: Multiple carboxylase deficiency
Answer: A: Multiple carboxylase deficiency 
Explanation: Multiple carboxylase/biotinidase deficiency:- autosomal recessive disorder due to defect in holocarboxylase synthase or biotinidase deficiency. Clinical features:- -Metabolic ketoacidosis -Diffuse rash -Alopecia -Seizures -Intellectual disability