This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pharmacology
The mechanism of action of cyclosporine is: 
Select and explain. 
A. Inhibits IL-2 receptors, B. Inhibits TNF alpha, C. Decrease in transcription of IL-2 gene, D. Targets inactivated T cells
C: Decrease in transcription of IL-2 gene
Answer: C: Decrease in transcription of IL-2 gene 
Explanation: Cyclosporine calcineurin inhibitor inhibits the dephosphorylation of NFAT leading to blocked of T cell activation by preventing IL2 Transcription. Tacrolimus (FK506):- is also calcineurin inhibitor which binds FK506 binding protein. IL2 receptor are blocked by Basiliximab, Daclizumab. TNF alphaBlocker :- Infliximab