This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Anatomy
Management of carcinoma breast in 2nd trimester are all except 
Select and explain. 
A. Chemotherapy Doxirubicin+cyclophosphamide+5FU, B. Mastectomy, C. Focal 3D, D. Breast Conservative surgery is a valid option
C: Focal 3D
Answer: C: Focal 3D 
Explanation: If the diagnosis of breast cancer is made in the first or early second trimester of pregnancy, lumpectomy and axillary dissection can be followed by chemotherapy after the first trimester and radiation after delivery. Chemotherapy is indicated for node-positive cancers or node-negative tumors greater than 1 cm. Current chemotherapeutic regimens are relatively safe after the first trimester, when the teratogenic risk is greatest. Generally, treatment regimens are the same as for non- pregnant patients with dose alterations because the increased plasma volume, the hypoalbuminemia, and the fact that almost all chemotherapeutic agents cross the placenta change the pharmacokinetics of the drugs. Ref: Sabiston 20th edition Pgno: 2060