This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2019, Subject name: Pathology
MRP 2 and conjugated hyperbilirubinemia associated with which of the following? 
Select and explain. 
A. Criggler Najjar syndrome type I, B. Criggler Najjar syndrome type II, C. Dubin Johnson syndrome, D. Rotor syndrome
C: Dubin Johnson syndrome
Answer: C: Dubin Johnson syndrome 
Explanation: Dubin-Johnson Syndrome:- Defect in canalicular protein called MRP2 leading to increase in conjugated bilirubin (CB). Criggler Najjar Syndrome type I and type II has decrease activity of UDP-glucuronodyltransferases leading to increase unconjugated bilirubin (UCB) which enters CNS and can cause kernicterus.