This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Pharmacology
Mechanism of action of statins: 
Select and explain. 
A. Inhibit HMG CoA synthase, B. Stimulate HMG CoA reductase, C. Inhibit HMG CoA reductase, D. Stimulate HMG CoA synthase
C: Inhibit HMG CoA reductase
Answer: C: Inhibit HMG CoA reductase 
Explanation: Ref: KDT 6th ed. pg. 614* HMG-CoA Reductase Inhibitors (statins): This class of compound is the most efficacious and best tolerated hypolipidaemic drugs.* MOA: Competitively inhibit conversion of HMG-CoA to mevalonate by the enzyme HMG-CoA reductase.* Drugs (Statins): Lovastatin, Simvastatin, Pravstatin, Atorvastatin, Rosuvastatin* All statins are given at night except: Rosuvastatin, Atorvastain (can be given at anytime)* Major side effects of statins: Myopathy* Most potent statin: Pitavastain