This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Gluten sensitive enteropathy is most strongly associated with which of the following? 
Select and explain. 
A. HLA DQ2, B. HLA DR4, C. HLA DQ3, D. Blood group 'B'
A: HLA DQ2
Answer: A: HLA DQ2 
Explanation: 95% of patients with gluten sensitive enteropathy express HLA DQ2 histocompatibility antigen on chromosome 6. In celiac sprue, the fundamental disorder is a sensitivity to gluten. When small intestinal mucosa is exposed to gluten, there is intraepithelial accumulation of cytotoxic T cells and helper T cell in the lamina propria. Cytokines released by the T cells in turn damage intestinal enterocytes.Ref: Robbins Pathologic Basis of Disease, 6th Edition, Page 813.