This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
Which of the following statement about imipenem is most accurate? 
Select and explain. 
A. The drug has a narrow spectrum of anti-bacterial action, B. It is used in fixed combination with sulbactam, C. Imipenem is highly susceptible to beta lactamase produced by enterobacteriaciae, D. In renal dysfunction, dosage reduction are necessary to avoid seizures
D: In renal dysfunction, dosage reduction are necessary to avoid seizures
Answer: D: In renal dysfunction, dosage reduction are necessary to avoid seizures 
Explanation: lmipenem It is an extremely potent and broad-spectrum