This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
A 45 yrs old man presents with progressive cervical lymph nodes enlargement, since 3 months; most diagnostic investigation is - 
Select and explain. 
A. Xray soft tissue, B. FNAC, C. Lymph node biopsy, D. None of the above
C: Lymph node biopsy
Answer: C: Lymph node biopsy 
Explanation: Ans. is 'c' i.e., Lymph node biopsy Harrison writes that in cases of lymphadenopathy, if the patient's history and physical findings are suggestive of malignancy, then a prompt lymph node biopsy (excisional biopsy) should be done. FNAC is not of much use, as it does not provide enough tissue to reach a diagnosis. ("FNAC should be reserved for thyroid nodules and for confirmation of relapse in patients whose primary diagnosis is known." - Harrison)