This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Parasitology, Subject name: Microbiology
The pathogenicity of E. histolytica is indicated by: 
Select and explain. 
A. Zymodeme pattern, B. Size, C. Nuclear pattern, D. ELISA test
A: Zymodeme pattern
Answer: A: Zymodeme pattern 
Explanation: Ans. is 'a' i.e., Zymodeme patternZymodeme (isoenzyme) analysis: E. histolytica possesses several isoenzymes like malic enzyme, hexokinase, isomerase and phosphoglucomutase and these isoenzymes contribute in pathogenesis. When these isoenzymes are subjected to electrophoresis based on electrophoretic pattern (Zymodeme pattern) and mobility of these isoenzymes, Entamoeba can be diagnosed and speciated.