This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Retina, Subject name: Ophthalmology
Which of the following agents is not used in the treatment of Diabetic Macular Edema/Retinopathy: 
Select and explain. 
A. Ruboxistaurim, B. Pyridazinones, C. Benfotiamine, D. Tamoxifen
D: Tamoxifen
Answer: D: Tamoxifen 
Explanation: Ans. (d) TamoxifenRef: Yanoff 3/e, p. 645Tamoxifen is known to cause retinopathy and macular edema as an adverse effect. It is not used in the treatment of Diabetic Macular edema or retinopathy.* Ruboxistaurin - PKC inhibitor* Pyridazinones/Spiroimides/corbotyliz acid -- aldose reductase inhibitors* Benfoliamine -|levels of AGE's