This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
In well fed state, the activity of Carnitine Palmitoyl Transferase-1 in outer mitochondrial membrane is inhibited by: 
Select and explain. 
A. Glucose, B. Acetyl-CoA, C. Malonyl-CoA, D. Pyruvate
C: Malonyl-CoA
Answer: C: Malonyl-CoA 
Explanation: Ans. C. Malonyl-CoA(Ref Harper 31/e page 214)Fatty acid oxidation is inhibited in the well fed state because, CPT-I activity is low in fed state because of inhibition by malonyl-CoA, the initial intermediate in fatty acid synthesis formed by acetyl-CoA carboxylase.