This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Graft rejection is - 
Select and explain. 
A. Cell mediated, B. Humoral, C. Both, D. None
C: Both
Answer: C: Both 
Explanation: harshmohan textbook of pathology 7th edition. *rejection of allograft involves both cell mediated and humoral immunity .cell mediated reaction is mainly responsible for graft rejection and are mediated by T cells.in addition to cell mediated reaction a role for humoral antibodies in ceain rejection reaction has been suggested. These included pre formed circulating antibodies due to pre sensitization of the recipient before transplantation.