This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Maintenance dose depends on ? 
Select and explain. 
A. Clearance, B. Volume of distribution, C. Metabolism, D. Absorption
A: Clearance
Answer: A: Clearance 
Explanation: Ans. is 'a' i.e., Clearance o Loading dose is governed by volume of distribution. o Maintenance dose is governed by clearance or t1/2.