This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Beta oxidation of fatty acids, Subject name: Biochemistry
Ketogenesis takes place in: 
Select and explain. 
A. Hepatic mitochondria, B. Hepatic cytoplasm, C. Hepatic microsome, D. Hepatic lysosome
A: Hepatic mitochondria
Answer: A: Hepatic mitochondria 
Explanation: Fatty acid oxidation takes place in mitochondria. Ketogenesis also takes place in mitochondria. HMG-CoA synthase is present in both cytosol and mitochondria. Cytosolic HMG-CoA synthase is involved in cholesterol synthesis. Mitochondrial HMG-CoA synthase is involved in ketogenesis.