This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following increases the susceptibility to coronary aery disease? 
Select and explain. 
A. Nephrotic syndrome, B. Von willebrand disease, C. Type V hyperlipoproteinemia, D. Systemic lupus erythematosus
A: Nephrotic syndrome
Answer: A: Nephrotic syndrome 
Explanation: Patients with nephrotic syndrome develop hyperlipidemia and hypercholesterolemia, secondary to increased hepatic synthesis of lipoproteins and decreased clearance of lipoproteins from the circulation. Hyperlipidemia in these patients also cause systemic atherosclerosis. Marked reduction of HDL receptor protein expression also contribute to increased atherosclerosis. All of these, acts as predisposing factors for the development of coronary aery disease. Ref: Heptinstall's Pathology of The Kidney, Volume 1 By J. Charles Jennette, Page 132; Therapy of Renal Diseases and Related Disorders By Wadi N. Suki, 2nd Edition, Chapter 321; Current Medical Diagnosis and Treatment, 2012, Chapter 22.