This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
A patient receives a toxic dose of lignocaine i.v., the patient is likely to exhibit: 
Select and explain. 
A. Excessive salivation, B. Mydriasis and diarrhea, C. Respiratory paralysis, D. Seizures and coma
D: Seizures and coma
Answer: D: Seizures and coma 
Explanation: (Ref: KDT 6/e p356) lf LA reaches the blood stream, most prominent adverse effects are related to CNS and CVS. ln CNS, stimulation (convulsions) followed by depression (coma) is seen. Initial stimulation is due to inhibition of the inhibitory neurons.