This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anaesthesia, Subject name: Pharmacology
All of the following are propeies of local anesthetics EXCEPT: 
Select and explain. 
A. Blockade of voltage dependent Na+ channels, B. Preferential binding to resting channels, C. Slowing of axonal impulse conduction, D. Increase in the membrane refractory period
B: Preferential binding to resting channels
Answer: B: Preferential binding to resting channels 
Explanation: - Local anesthetic receptor is located within the channel in its intracellular half. - LA traverses the membrane in unionized form. - LAs act from within the neuron and are more active when the neuron is rapidly firing (i.e., Na+ channels are open). so it doesnot act in resting form.