This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
Somatic mutation E17K in the PH domain of AKT-1 gene mutation is associated with? 
Select and explain. 
A. Stomach, B. Breast, C. Ovary, D. Pancreas
B: Breast
Answer: B: Breast 
Explanation: Ans. (b) Breast(Ref: Atlasgeneticsoncology.org/Genes/AKT1)Hyper-activation of AKT1 has been found associated to several human cancers:*Thyroid carcinoma*Breast carcinoma*Non-small cell lung carcinoma*Gastric carcinomaNow coming to question: Somatic mutation E17K occurs in the PH domain of AKT1 in 8% of human breast cancers. This mutation also occurs in 6% of colorectal cancers.