This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
glipizide differs from chlorpropamide in that it: 
Select and explain. 
A. Is more potent, B. Is longer acting, C. Does not lower blood sugar in nondiabetic subjects, D. Is less prone to cause hypoglycemic reaction
A: Is more potent
Answer: A: Is more potent 
Explanation: (Ref: KDT 6/e p266) Second generation (like glipizide) sulfonylureas are more potent than first generation agents (like chlorpropamide). Chlorpropamide is the longest acting sulfonylurea. Sulfonylureas can cause hypoglycemia (even in non-diabetics) due to release insulin.