This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Anti-inflammatory action of coicosteroids is due to blocking of- 
Select and explain. 
A. 15 Lipo oxygenase, B. Prostaglandin synthases, C. Thromboxane synthases, D. Breakdown of phospholipids
D: Breakdown of phospholipids
Answer: D: Breakdown of phospholipids 
Explanation: Ans. is 'd' i.e., Breakdown of phospholipids o The most impoant mechanism of coicosteroids as antiinflammatory agents is the limitation of recruitment (chemotaxis) of inflammatory cells at the local side and production ofproinflammatory mediators like PGs, LTs, PAF through inhibition ofphospholipase At o Phospolipase A, acts on membrane phospholipids and causes their breakdwon to form arachidonic acid. This is inhibited by coicosteroids.