This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Aetiological factors, Subject name: Gynaecology & Obstetrics
Koilocytes with perinuclear halo on pap smear is pathognomic of? 
Select and explain. 
A. HPV infection, B. Metaplasia, C. Dysplasia, D. Bacterial vaginosis
A: HPV infection
Answer: A: HPV infection 
Explanation: ANSWER: (A) HPV infectionREF: Shaw's Gynecology 13th ed p- 78, The pap test by Richard M. DeMay page 49-50"Koilocytes, dyskeratocytes, macrocytes, etc. are some of the cytologic findings that are characteristic of condylomas (HPV). Koilocytes with perinuclear halo is pathognomonic of HPV infection"ConditionType of cellEstrogen dominated uterusNormal cornified cellsProgesterone dominated uterusIntermediate cellspregnancyIntermediate cells , Navicular cellsmenopausalBasal, parabasalHPVKoilocytes, dyskeratocytes, macrocytes with perinuclear halo.