This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which immunoglobulin combination is predominantly in pathogenesis of cryglobulinemic vasculitis 
Select and explain. 
A. IgA + IgG, B. IgM + IgG, C. IgA + IgE, D. IgE + IgM
B: IgM + IgG
Answer: B: IgM + IgG 
Explanation: Answer- B. IgM + IgGcryoglobulinemic vasculitis occurs when an aberrant immune response to hepatitis C infection leads to the formation of immune complexes consisting of hepatitis C antigens,polyclonal hepatitis C-specific IgG, and monoclonal IgM rheumatoid factor.