This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Splenomegaly may be a feature of: March 2013 
Select and explain. 
A. Megaloblastic anemia, B. Sickle cell anemia, C. Thalassemia, D. G6PD deficiency
B: Sickle cell anemia
Answer: B: Sickle cell anemia 
Explanation: Ans. B i.e. Sickle cell anemia Splenomegaly Splenomegaly refers strictly to spleen enlargement, and is distinct from hyperspineism , which connotes overactive function by a spleen of any size. Splenomegaly and hypersplenism should not be confused. Each may be found separately, or they may coexist. Clinically if a spleen is palpable, it means it is enlarged as it has to undergo enlargement by at least two folds to become palpable. However, the tip of the spleen may be palpable in a newborn baby up to 3 months of age Early sickle cell anemia may present with splenomegaly