This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology and Rheumatology, Subject name: Medicine
Which of the following autoantibodies is most likely to be present in a patient with SLE? 
Select and explain. 
A. Anti-ds DNA, B. Anti Ro, C. Anti-Phospholipid, D. Anti-Ribosomal P
A: Anti-ds DNA
Answer: A: Anti-ds DNA 
Explanation: Ans. A. Anti-ds DNAAnti-ds DNA is present in 65% cases of SLE and is a marker of development of lupus nephritis.Anti Ro is present in 30% cases and is a marker of cutaneous lupus and development of congenital CHB in the baby of mother with SLE. Anti-phospholipid are present in 40% cases and are a marker of recurrent fetal loss and thrombosis.Anti-ribosomal P antibody is present in 20% cases only and is a marker of psychosis