This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Small and Large Intestines, Subject name: Pathology
Hirschsprung colon is due to - 
Select and explain. 
A. Muscle atrophy in muscularis mucosa, B. Loss of intrinsic enteric plexuses, C. Loss of extrinsic nerve supply, D. None
B: Loss of intrinsic enteric plexuses
Answer: B: Loss of intrinsic enteric plexuses 
Explanation: Ans. is 'b' i.e., Loss of intrinsic enteric plexuses Pathogenesis of Hirchsprung diseaseo The entric neuronal plexuses develops from neural crest cells, which migrate into the bowel wall during development, mostly in a cephalad to caudad direction.o Hirschsprung disease results when the migration of neural crest cells arrests at some point before reaching the anus - inappropriate premature death.o This produces an intestinal segment that lacks both meissner submucosal and aurebach myenteric plexus, o Loss of enteric neural coordination leads to functional obstruction and intestinal dilation proximal to the affected segment.