This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
Earliest manifestation of diabetic retinopathy is 
Select and explain. 
A. Soft exudates/Cotton wool spot, B. Dot haemorrhage, C. Hard exudates, D. Microaneurysm
D: Microaneurysm
Answer: D: Microaneurysm 
Explanation: D i.e. Microaneurysm Microaneurysms are located in the inner nuclear layer and are the earliest and most characteristic ocular lesion Q of diabetic retinopathy.