This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urea cycle, Subject name: Biochemistry
A patient presented to casualty with nausea, vomiting. Intravenous glucose was given & the patient recovered. After few months, patient presented with same complaints. Blood glutamine was found to be increased. Also uracil levels were raised. What is the diagnosis? 
Select and explain. 
A. CPS-I deficiency, B. Argino succinate synthetase deficiency, C. CPS-II deficiency, D. Ornithine trans carbamoylase deficiency
D: Ornithine trans carbamoylase deficiency
Answer: D: Ornithine trans carbamoylase deficiency 
Explanation: Increase in Blood glutamine indicates hyperammonemia, which occurs in all enzyme defect of urea cycle Increased uracil indicate Ornithine trans carbamoylase deficiency Orotic acid, OMP, UMP are increased in OTC defect. OTC deficiency (Excess carbamoyl phosphate from mitochondria enters cytoplasm and takes pa in pyrimidine synthesis) WITH REGARDS TO OTHER OPTIONS If citrulline is increased then it is Argino succinate synthetase deficiency. ( OPTION II) CPS-II (carbamoyl phosphate synthetase-II) is enzyme involved in pyrimidine synthesis, not in urea cycle. (OPTION III)