This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Medicine
Ataxia telangiectasia is associated with all of the following except 
Select and explain. 
A. Recurrent sinopulmonary infections, B. Lymphatic reticular malignancies, C. Increased fraction of IgA immunoglobulins, D. Insulin resistance
C: Increased fraction of IgA immunoglobulins
Answer: C: Increased fraction of IgA immunoglobulins 
Explanation: Although B lymphocytic development is normal most patients are deficient in serum IgA and IgEAtaxia telangiectasia:An autosomal recessive genetic disorderMutation of AT gene located on chromosome 11(11q 22-33)A defect in DNA repair, increased number of chromosomal breaksAlfa-fetoprotein and carcinoembryonic antigen levels are increasedManifestations are:AtaxiaOculocutaneous telangiectasiasMalignanciesHodgkin's lymphomaAcute leukemiaImmunodeficiency Endocrinal Ref: Harrison; 18/e; p3344