This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
Which of the following prokinetic drugs produces extrapyramidal side effects? 
Select and explain. 
A. Metoclopramide, B. Cisapride, C. Domperidone, D. All of the above
A: Metoclopramide
Answer: A: Metoclopramide 
Explanation: (Ref: KDT 6/e p643, 644) Metoclopramide and domperidone act by blocking D2 receptors. Metoclopramide can cross BBB whereas domperidone cannot. Therefore, metoclopramide can produce extra-pyramidal adverse effects while domperidone is devoid of it. Cisapride acts as 5HT4 agonist. It can cause torsades de pointes.