This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adrenal, Subject name: Pharmacology
Select the regime of coicosteroids which has the maximum adverse effect potential? 
Select and explain. 
A. Prednisolone 20 mg/day oral for one year, B. Prednisolone 60 mg/day oral for 7 days, C. Dexamethasone 4 mg intravenous daily for 3 days, D. Methyl-prednisolone 1000 mg intravenous twice single dose
A: Prednisolone 20 mg/day oral for one year
Answer: A: Prednisolone 20 mg/day oral for one year 
Explanation: * If used for more than two weeks, coicosteroids can lead to HPA axis suppession. If discontinued abruptly, precipitation of acute adrenal insufficiency can result. This is the most serious adverse effect seen with the use of coicosteroids that can cause death of the patient.