This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
Gastric carcinoma is associated with all EXCEPT 
Select and explain. 
A. Inactivation of p53, B. Over expression of C-erb, C. Over expression of C-met, D. Circulating autoimmune antibodies
D: Circulating autoimmune antibodies
Answer: D: Circulating autoimmune antibodies 
Explanation: Gastric carcinoma - mutation loss of function mutation in the tumor suppressor gene CDH1. BRCA2 mutations Mutations of TP53 Loss of function mutation in the WNT signaling pathway (APC gene), gain of function in the gene encoding beta-catenin Loss of function in genes regulating apoptosis(BAX), cell cycle regulators(CDKN2A). C-met and C-erb(ERBB2) are members of K (receptor tyrosine kinase ) family. There is no autoimmune basis for gastric carcinoma. Ref: GENERAL AND SYSTEMIC PATHOLOGY RAMDAS NAYAK, 2nd edition, page 487