This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Staing point of apoptosis for programme cell death is - 
Select and explain. 
A. Activation of endonuclease, B. Release of enzyme, C. Accumulation of calcium, D. None
D: None
Answer: D: None 
Explanation: Ans. is 'None'o Activation of caspases (not endonuclease) is central in the pathogenesis of apoptosis."A family of proteins known as caspases are typically activated in the early state of apoptosis - Anderson." o After activation of caspases, they (caspases) activate endonuclease.For one answer go ahead with option 'a', because amongst the given option only activation of endonuclease is related to pathogenesis of apoptosis.