This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Interactions of NMJ Blockers, Subject name: Anaesthesia
Antibiotic potentiating the effect of NM blocker- 
Select and explain. 
A. Erythromycin, B. Aminoglycoside, C. Co-trimoxazole, D. Nitrofurantoin
B: Aminoglycoside
Answer: B: Aminoglycoside 
Explanation: Ans. is 'b' i.e., Aminoglycoside Important interactions of skeletal muscle relaxantso General anaesthetics potentiate competitive blockers in the following order : isoflurane (most), sevoflurane, desflurane, enflurane, Holothane and nitrous oxide (least)..o Anticholinesterase (neostigmine, pyridostigmine & edrophonium) reverse the action of competitive blockers, they can enhance depolarizing neuromuscular blockers.o Calcium channel blockers (verapamil) potentiate both competitive and depolarizing neuromuscular blockers.o Diuretics produce hypokalemia which enhances competitive block.o Diazepam, propranolol and quinidine intensify competitive block.o Aminoglycosides, tetracycline, polypeptide antibiotics, clindamycin and lincomycin can potentiate competitive block.o High doses of glucocorticoids reduce the effect of competitive blockers.