This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neuro-ophthalmology, Subject name: Ophthalmology
In Holmes-Adie pupil all are true except - 
Select and explain. 
A. There is absent or retarded pupil reactions to light and near, B. Most cases are bilateral, C. Causes reduced or absent accommodation, D. Constricts with 2.5% methacholine
B: Most cases are bilateral
Answer: B: Most cases are bilateral 
Explanation: The Adie's tonic pupil. In this condition reaction to light is absent and to near reflex is very slow and tonic. The affected pupil is larger (anisocoria). Its exact cause is not known. It is usually unilateral, associated with absent knee jerk and occurs more often in young women. Adie's pupil constricts with weak pilocarpine (0.125%) drops, while normal pupil does not. Ref:AK Khurana 4thE pg 293