This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
Which of the following is not a systemic route of drug administration? 
Select and explain. 
A. Transdermal, B. Intravenous, C. Subcutaneous, D. Intraarterial
D: Intraarterial
Answer: D: Intraarterial 
Explanation: Ans. D. Intraarteriala. Intraarterial drug administration is used to expose a particular organ to drug supplied by the artery and hence it is a local route.b. This decreases risk of systemic toxicity.c. Anticancer drugs for hepatocellular carcinoma and head and neck cancer are given by intraarterial route.