This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Physiology
Through which of the following does glucose mediated insulin release occur? 
Select and explain. 
A. ATP sensitive K+ channels, B. cAMP, C. Carrier mediated, D. Receptor phosphorylation
A: ATP sensitive K+ channels
Answer: A: ATP sensitive K+ channels 
Explanation: Glucose-mediated insulin release occurs through ATP sensitive K+ channels. Increased blood glucose concentration is the primary controller of insulin secretion. Inside the beta cells, glucose is conveed to glucose-6-phosphate and later ATP is generated. This ATP closes ATP sensitive potassium channels, leading to rise in K+ and depolarisation. This in turn causes opening of voltage gated Ca2+ channels and influx of Ca+. This ultimately leads to secretion of insulin exocytosis. Ref: Guyton and Hall 13th edition Pgno: 990