This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
Which of the following is not a channelopathy?- 
Select and explain. 
A. Cystic fibrosis, B. Liddle's syndrome, C. Tay-sachs disease, D. Hypokalemic periodic paralysis
C: Tay-sachs disease
Answer: C: Tay-sachs disease 
Explanation: Channelopathies are diseases caused by the disturbed function of ion channel subunits or the proteins that regulate them. Tay-Sachs disease is a GM2 gangliosidosis caused by the deficiency of enzyme hexosaminidase, subunit.