This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General obstetrics, Subject name: Gynaecology & Obstetrics
Which of the following steps has proven benefit in decreasing puerperal infection following cesarean section? 
Select and explain. 
A. Non closure of peritoneum, B. Single layer uterine closure, C. Administration of single dose of ampicillin or 1st generation cephalosporin at the time of cesarean, D. Skin closure with staples than with suture
C: Administration of single dose of ampicillin or 1st generation cephalosporin at the time of cesarean
Answer: C: Administration of single dose of ampicillin or 1st generation cephalosporin at the time of cesarean 
Explanation: Prophylactic antibiotics for the cesarean section have been conclusively proven to be beneficial.The first dose is administered at clamping and at least 2 more doses given 8th hourly intravenously in elective cases. Single-dose prophylaxis has been recommended by the ACOG. Both ampicillin and first-generation cephalosporins have been shown to have equal value.(refer to pgno: 436 Sheila 2nd edition )