This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Chloroquine is a weak base that neutralizes acidic organelles. In a pancreatic beta cell, which of the following would be a direct effect of chloroquine treatment? 
Select and explain. 
A. Increase proinsulin content in secretory vesicles, B. Increased release of C peptide, C. Increased number of amylase-containing secretory vesicles, D. Reduced translation of glucagon mRNA
A: Increase proinsulin content in secretory vesicles
Answer: A: Increase proinsulin content in secretory vesicles 
Explanation: Increased proinsulin content in secretory vesicles * Chloroquine neutralizes acidic compaments such as the sectetory vesicles. * Chloroquine treatment inhibits the conversion of proinsulin to insulin, resulting in decreased formation of insulin within secretory vesicles. * Acidification causes concentration of the contents of secretory vesicles, facilitates breakdown of the contents of phagosomes and lysosomes, and is involved in the cleavage of prohormones to their active forms (e.g., proinsulin to insulin).