This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Pathology
Factor V mutation is commonly associated with:- 
Select and explain. 
A. Hemahrosis, B. Hematemesis, C. Thrombosis, D. Epistaxis
C: Thrombosis
Answer: C: Thrombosis 
Explanation: Factor V mutation also called as leiden's mutation Leiden's mutation is characterized by substitution of amino acid at the position 506 Arginine at this position is replaced by glutamine Protein C and S inhibit the activity of Factor V and VIII In Factor V mutation, Factor V gets resistant to the action of protein C and S, then Factor V won't get inhibited, which is responsible for causing higher risk of development of thrombosis Inheritable causes of hypercoagulability Factor V mutation (commonest) Mutation in the activity of homocysteine Mutation in the activity of prothrombin gene