This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Fluid & Electrolyte, Subject name: Medicine
Not useful for acute Hypercalcemia? 
Select and explain. 
A. Normal saline, B. Calcitonin, C. Furosemide, D. Bisphosphonates
C: Furosemide
Answer: C: Furosemide 
Explanation: Ans. is 'c' i.e., Furosemide Treatment for hypercalcemia depends upono The underlying disease.o The severity of hypercalcemia.o The serum inorganic phosphate level ando The renal hepatic and bone marrow function. o Mild hvpercalcemias< 3 mmol/l (12 mg/dl)-Managed by hydration aloneo More severe hvoercalcemia3.2 to 3.7 mmol/l (13 to 15 mg/dl)-Requires rapid correction measures other than hydration.It requires combination of approaches.o Life threatening hypercalcemia>3.7 mmol/L (15 mg/dL)-Requires emergency measures TreatementOnset of ActionDuration of ActionAdvantagesDisadvantagesMost Useful Therapies Hydration with salineHoursDuring infusionRehydration invariably neededVolume overloadForced diuresis; saline plus loop diureticHoursDuring treatmentRapid actionVolume overload, cardiac decompensation, intesive monitoring, eletrolyte disturbance, inconvenienceBisphosphonates Pamidronate1-2 days10-14 days to weeksHigh potency, intermediate onset of actionFever in 20%, hypophosphatemia, hypocalcemia rarely jaw necrosisZolendronate1-2 days> 3 weeksSame as for pamidronate (may last longer)Same as pamidronate aboveCalcitoninHours1-2 daysRapid onset of action; useful as adjunct in severe hypercalcemiaRapid tachyphylaxisSpecial Use therapies PhosphateOral24 hDuring useChronic management (with hypophosphatemia); low toxicity if P< 4 mg/dLLimited use except as adjuvant or chronic therapyGlucocorticoidsDaysDays, weeksOral therapy, antitumor agentActive only in certain malignancies vitamin D excess and sarcoidosis; glucocorticoid side effectsDialysisHoursDuring use and 24-48 afterwardUseful in renal failure; onset of effect in hours; can immediately reverse life-theratening hypercalcemiaComplex procedure, reserved for extreme or special circumstances