This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pathology
Which of the following is not true about medullary carcinoma of thyroid ? 
Select and explain. 
A. Origin is from 'C' cells of thyroid, B. Component of MEN- 1, C. Multicentric in origin, D. Amyloid deposition
B: Component of MEN- 1
Answer: B: Component of MEN- 1 
Explanation: Medullary carcinoma of thyroid is a neuroendocrine neoplasm which is multicentric and derived from C cells of thyroid. It is characterised by acellular amyloid deposits derived from calcitonin in stroma of the cells. It is a component of MEN 2A or MEN 2B and not MEN 1. Ref: Robbins and cotrans 9e Pg 1099 Ref IMG