This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
All of the following are (Jnconjugated Hyperbilirubinemias EXCEPT 
Select and explain. 
A. Criggler Najjar syndrome Type 1, B. Gilbert's syndrome, C. Dubin Johnson syndrome, D. Criggler Najjar syndrome Type 2
C: Dubin Johnson syndrome
Answer: C: Dubin Johnson syndrome 
Explanation: (C) Dubin Johnson syndrome # Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder of bilirubin metabolism. Two distinct forms have been described, as follows: type 1 and type 2.> Type 1 CNS, first described in 1952 by Crigler and Najjar, is associated with neonatal unconjugated hyperbilirubinemia (high levels) and kernicterus.> Type 2 CNS (Arias syndrome), first described in 1962 by Arias, presents with a lower serum bilirubin level and responds to phenobarbital treatment.> CNS is elicited by a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT).> A markedly elevated unconjugated (indirect) hyperbilirubinemia is observed in inherited disorders such as Gilbert syndrome and CNS. Among the inherited unconjugated hyperbilirubinemias, Gilbert syndrome is believed to affect approximately 3-7% of the adult population.> Dubin Johnson syndrome & Rotor syndromes are inborn errors of metabolism which lead to conjugated hyperbilirubinemia