This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
The initiating mechanism in endotoxic shock is 
Select and explain. 
A. Peripheral vasodilation, B. Endothelial injury, C. Increased vascular permeability, D. Reduced cardiac output
B: Endothelial injury
Answer: B: Endothelial injury 
Explanation: ref Robbins 9/e p131-132 The principal mechanism for septic shock includes: Peripheral vasodilation and pooling of blood Endothelial activation/injury Leukocyte induced injury Disseminated intravascular coagulation Activation of cytokine cascades