This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adverse Drug Effect, Subject name: Pharmacology
Irreversible ototoxicity is caused by - 
Select and explain. 
A. Cisplatin, B. Cyclophosfamide, C. Bleomycin, D. Chlorambucil
A: Cisplatin
Answer: A: Cisplatin 
Explanation: Ans. is 'a' i.e., Cisplatin "Cisplatin induced hearing loss is usually bilateral and irreversible"Drugs causing ototoxicityA) Vestibular (primarily)o Aminoglycosides o Mustineo Quinidineo Quinineo Chloroquineo Vancomycino Furosemide o Ethacrynic acido Salicylates (high dose)B) Auditory (primarily)o NSAIDso Ethacrynic acido Vancomycino Aminoglycosideso Cisplatin