This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
Risk of having a child with Down syndrome: 
Select and explain. 
A. Is unaffected by maternal age, B. Decreases with increase in maternal age, C. Increases with increase in paternal age, D. Increases with increase in maternal age
D: Increases with increase in maternal age
Answer: D: Increases with increase in maternal age 
Explanation: d. Increases with increase in maternal age(Ref: Nelson's 20/e p 610-614)Risk of Down Syndrome Increased with Increase in Maternal AgeMaternal ageIncidence of Down Syndrome20 years1 in 150030 years1 in 90040 years1 in 10045 years1 in 30