This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Anatomy
Which of the following is not seen in a chronic case of sickle cell anemia 
Select and explain. 
A. Hepatomegaly, B. Pulmonary hypeension, C. Cardiomegaly, D. Splenomegaly
D: Splenomegaly
Answer: D: Splenomegaly 
Explanation: Ref Harrison 19 th ed pg 634 venooc- clusive component usually dominates the clinical course. Prominent manifestations include episodes of ischemic pain (i.e., painful crises) and ischemic malfunction or frank infarction in the spleen, central nervous system, bones, joints, liver, kidneys, and lungs .