This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Pathology
True about BCR-ABL 'trials' are all except: 
Select and explain. 
A. P190 has an indolent course, B. P190 is a bad prognostic factor, C. P230 is positive in chronic neutrophilic leukemia, D. P230 has an indolent course
A: P190 has an indolent course
Answer: A: P190 has an indolent course 
Explanation: BCR- ABL fusion is responsible for form action of Tyrosine kinase enzyme. Variant of Tyrosine kinase:- (1) 190 k Da:- seen in B-ALL (2) 210 KDa:- seen in CML (3) 230 KDa:- seen in CNL (chronic neutrophilic leukemia ) Aggressiveness of cancer based on size of Tyrosine kinase :- 190 >>>210>>230 KDa. 190 KDa seen in B-ALL :- most aggressive course B-ALL with translocation (9:22) has bad prognosis 230 KDa :- least aggressive course (indolent course)