This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Castleman disease is associated with ? 
Select and explain. 
A. HSV, B. CMV, C. EBV, D. HHV- 8
D: HHV- 8
Answer: D: HHV- 8 
Explanation: Ans. is 'd' i.e., HHV - 8 Castleman disease is group of lymphoproliferative disorders. Disease is caused by hypersecretion of IL-6. Release of these cytokines may be caused by HHV-8 in HHV-8 associated Multicentric Castleman Disease (MCD).