This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Coombs positive hemolytic anemia associated with: 
Select and explain. 
A. TTP, B. PAN, C. SLE, D. HUS
C: SLE
Answer: C: SLE 
Explanation: Answer is C (SLE) Coombs positive hemolytic anemia is a feature of autoimmune hemolytic anemia and is characteristically seen in SLE. Polvaeritis Nodosa (PAN) may also be associated with a Coombs positive hemolytic anemia. However this association is rare, and more commonly patients with PAN present either with an anemia of chronic disease or a microangiopathic hemolytic anemia. TTP and HUS are characteristically associated with Coombs negative microangiopathic hemolytic anemias.