This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Gene instability associated with malignancy is seen in - 
Select and explain. 
A. Klippel fiel syndrome, B. Ataxia telangiectasia, C. Marfan'g syndrome, D. EDS
B: Ataxia telangiectasia
Answer: B: Ataxia telangiectasia 
Explanation: Ans. is 'b' i.e., Ataxia telangiectasiaSyndromes of defective DNA repair have such a high level of chromosomal instability that they are known as chromosome-breakage syndromes or chromosomal instability syndromes.