This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
All are true statements about anticancer drugs except? 
Select and explain. 
A. Vincristine is a marrow sparing anticancer drug, B. Irinotecan is a topoisomerase II inhibitor, C. L-asparaginase can cause acute pancreatitis, D. Anthracyclines cause cardiotoxicity
B: Irinotecan is a topoisomerase II inhibitor
Answer: B: Irinotecan is a topoisomerase II inhibitor 
Explanation: Anthracyclines cause cardiotoxicity, prevented by dexrazoxane Bleomycin causes pulmonary fibrosis L-asparaginase cause allergy, acute pancreatitis Vincristine, vinblastine causes peripheral neuropathy & SIADH. But it is marrow sparing. Irinotecan is a topoisomerase I inhibitor used for colorectal carcinoma Topoisomerase II inhibitors are Etoposide, doxorubicin, Daunorubicin & anthracyclines.