This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Preterm Labour, Subject name: Gynaecology & Obstetrics
Which of the following risk factors is most commonly associated with chorioamnionitis? 
Select and explain. 
A. Maternal drug abuse, B. Poor maternal hygiene, C. Prior cesarean delivery, D. Prolonged rupture of membranes
D: Prolonged rupture of membranes
Answer: D: Prolonged rupture of membranes 
Explanation: Risk factor most commonly associated with chorioamnioitis- Prolonged rupture of membranes Ascending infection is most common and frequently is associated with prolonged membrane rupture and long labor. A variety of organisms may infect the membranes, umbilical cord, and eventually the fetus.