This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Deficiency of GpIIb-IIIa results in which of the following condition? 
Select and explain. 
A. Glanzmann thrombasthenia, B. Wiskot Aldrich syndrome, C. Bernard Soulier syndrome, D. None of the above
A: Glanzmann thrombasthenia
Answer: A: Glanzmann thrombasthenia 
Explanation: Platelet activation by ADP triggers a conformational change in the platelet GpIIb-IIIa receptors that induces binding to fibrinogen, a large protein that forms bridging interactions between platelets that promote platelet aggregation. Predictably, inherited deficiency of GpIIb-IIIa results in a bleeding disorder (Glanzmann thrombasthenia). Ref: Robbins 8th edition Chapter 4.