This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Parathyroids, Subject name: Pathology
A 40-year-old woman with a history of hyperparathyroidism presents with a 2-month history of burning epigastric pain. The pain can be relieved with antacids or food. The patient also repos a recent history of tarry stools. She denies taking aspirin or NSAIDs. Laboratory studies show a microcytic, hypochromic anemia . Gastroscopy reveals a bleeding mucosal defect in the antrum. Which of the following best characterizes the pathogenesis of epigastric pain in this patient? 
Select and explain. 
A. Decreased Calcium resorption by renal tubules, B. Decreased serum levels of PTH, C. Gastric nonresponsiveness to PTH, D. Increased secretion of Gastrin
D: Increased secretion of Gastrin
Answer: D: Increased secretion of Gastrin 
Explanation: - Given clinical features point towards Peptic ulcer disease, secondary to hyper-parathyroidism. - Incidence of peptic ulcer disease is increased in patients with hyperparathyroidism, because hypercalcemia increases serum gastrin, thereby stimulating gastric acid secretion. - None of the other choices are associated with gastric ulcers. - Peptic ulcers in context of MEN-1 may be secondary to Zollinger Ellison syndrome