This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pediatrics
Lesions of which of the hypothalamic nuclei cause diabetes insipidus: 
Select and explain. 
A. Dorsomedial nuclei, B. Supraoptic and paraventricular nuclei, C. Median preoptic nuclei, D. Ventromedial nuclei
B: Supraoptic and paraventricular nuclei
Answer: B: Supraoptic and paraventricular nuclei 
Explanation: b. Supraoptic and paraventricular nuclei(Ref: Nelson's 20/e p 348-349, Ghai 8/e p 511)Vasopressin, a 9-amino-acid peptide, has both antidiuretic and vascular pressor activity and is synthesized in the paraventricular and supraoptic nuclei of the hypothalamus.Deficiency of Vasopressin is responsible for Diabetes insipidus.