This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Primary Open-Angle Glaucoma and Related Conditions, Subject name: Ophthalmology
Which of the following drugs acts on trabecular meshwork and affects the aqueous outflow? 
Select and explain. 
A. Timolol, B. Pilocarpine, C. Brimonidine, D. Brinzolamide
B: Pilocarpine
Answer: B: Pilocarpine 
Explanation: Ans. b. Pilocarpine (Ref: Katzung 12/e p161; KDT 6/e p145)Pilocarpine acts on trabecular meshwork and affects the aqueous outflow.Drugs for GlaucomaMechanism of ActionBrimonidine* Lowers IOT by 20-27% by reducing aqueous production and by increasing uveoscleral flowQLatanoprost* Increase the uveoscleral outflowQ.Pilocarpine* Increases trabecular outflowQBetaxolol* Reduces aqueous secretion by ciliary bodyQ Drug/ClassAqueous secretionTrabecular outflowUveoscleral outflowBeta-blockers (Timolol)|--Adrenaline/dipivefrine|?||Brimonidine/apraclonidine|-|Prostaglandins (latanoprost)-|?|Miotics (pilocarpine)-|-Carbonic anhydrase inhibitors|--