This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
All of the following are good prognostic factors for acute lymphoblastic leukemia except 
Select and explain. 
A. Age of onset between 2-8 years, B. Hyperdiploidy, trisomy of chromosomes 4, 7 and 10 and + (12;21), C. Intial WBC count less than 50000, D. + (9;22), + (8;14)
D: + (9;22), + (8;14)
Answer: D: + (9;22), + (8;14) 
Explanation: Favorable Prognostic markers
Unfevorable prognosis markers




Age between 2 and 10 years




Below 2 years and above 10 years






Low white cell count




High (more than 50,000 cells / cumm)






Hyperdiploidy




Hyoploidy






Trisomy of chromosome 4, 7 and 10 and + (12;21)




+ (9;22) (the philadelphia chromosome)