This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrine, Subject name: Pathology
Which one of the following variants of papillary carcinoma thyroid occurs in younger individuals including children with lymphonodal metastases in almost all cases and morphologically simulates Hashimoto thyroiditis is: 
Select and explain. 
A. Tall-cell variant, B. Follicular variant, C. Diffuse sclerosing variant, D. Oncocyticvarient
C: Diffuse sclerosing variant
Answer: C: Diffuse sclerosing variant 
Explanation: Ans. (c) Diffuse sclerosing variant(Ref: Robbins 9th/pg 1097-1098)Diffuse sclerosing variant of papillary carcinoma*It occurs in younger individuals, including children.*The tumor has a prominent papillary growth pattern intermixed with solid areas containing nests of squamous metaplasia.*There is extensive, diffuse fibrosis throughout the thyroid gland, often associated with a prominent lymphocytic infiltrate, simulating Hashimoto thyroiditis.*Lymph node metastases are present in almost all cases.*Diffuse sclerosing variant carcinomas lack BRAF mutations, but RET/PTC translocations are found in approximately half the cases.