This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Karyotyping is useful in the diagnosis of? 
Select and explain. 
A. Autosomal recessive disorders, B. Chromosomal abnormalities, C. X-linked recessive disorders, D. Biochemical abnormalities
B: Chromosomal abnormalities
Answer: B: Chromosomal abnormalities 
Explanation: Karyotyping is the study of chromosomes and is used in cytogenetics to study the chromosomal abnormalities. After arresting the cells in metaphase the chromosomes are examined to see for:
• Change in Number of chromosomes - To detect abnormalities in chromosome numbers such as aneuploidy (trisomy, tetrasomy), polyploidy.
• For detection of structural chromosomal anomalies such as translocation, deletions, inversion of chromosomes