This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
Which enzyme is deficient in c/c alcoholics? 
Select and explain. 
A. Aconitase, B. Citrate synthase, C. Isocitrate dehydrogenase, D. Alpha ketoglutarate dehydrogenase
D: Alpha ketoglutarate dehydrogenase
Answer: D: Alpha ketoglutarate dehydrogenase 
Explanation: Ans. D. Alpha ketoglutarate dehydrogenaseBecause in alcoholics there is thiamine deficiency, so a thiamine dependent enzyme will be deficient.So answer is Alpha Ketoglutarate Dehydrogenase.