This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
Drug of choice for CML 
Select and explain. 
A. Imitanib mesylate, B. Fludarabine, C. A1 trans retinoic acid (for AML 3), D. Methotrexate
A: Imitanib mesylate
Answer: A: Imitanib mesylate 
Explanation: Ans. (a) Imitanib mesylate (Doc for CML & GIST - Imatinib Mesylate)Ref. KD Tripathi 6th Ed. / 828 & 832IMATINIB* It inhibits the tyrosine protein kinases in chronic myeloid leukaemia (CML) cells and and c-kit receptor found in gastrointestinal stromal tumour (GIST).* Adverse effects are fluid retention, edema, vomiting, abdominal pain, myalgia and liver damageDrugs of choice for some commonly asked malignanciesMalignancyFirst line drugsChronic Lymphatic leukaemiaFludarabineChronic Myeloid leukaemiaImatinibHairy cell leukemiaCLADRIBINEMultiple myelomaMelphalanChoriocarcinomaMethotrexateProstate carcinomaBicalutamide/Flutamide