This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
All of the following drugs are useful in nephrogenic diabetes insipidus except 
Select and explain. 
A. Amiloride, B. Indomethacin, C. Chlorpropamide, D. Thiazide diuretics
C: Chlorpropamide
Answer: C: Chlorpropamide 
Explanation: The polyuria and polydipsia of nephrogenic DI are not affected by treatment with standard doses of DDAVP. Treatment with conventional doses of a thiazide diuretic and/or amiloride in conjunction with a low-sodium diet and a prostaglandin synthesis inhibitor (e.g., indomethacin) usually reduces the polyuria and polydipsia by 30-70% and may eliminate them completely in some patients. ref : Harrisons 20th ed 2279.