This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
Risk of breast cancer is highest in 
Select and explain. 
A. Lobular carcinoma in situ, B. Proliferative disease without atypia, C. Proliferative disease with atypia, D. Atypical ductal hyperplasia
A: Lobular carcinoma in situ
Answer: A: Lobular carcinoma in situ 
Explanation: Atypical ductal or lobular hyperplasia are proliferative disease with atypia. Lobular carcinoma in situ carries the highest riskHISTOLOGIC DIAGNOSIS ESTIMATESRRNonproliferative disease1.0Proliferative disease without atypia1.3-1.9Proliferative disease with atypia3.7-4.2Proliferative disease with atypia and strong family history4-9LCIS >7Ref: Sabiston 20e, page: 832