This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Paroxysmal nocturnal hemoglobinuria is associated with all of the following conditions, except: 
Select and explain. 
A. Aplastic anemia, B. Increased LAP scores, C. Venous thrombosis, D. Iron deficiency anemia
B: Increased LAP scores
Answer: B: Increased LAP scores 
Explanation: In paroxysmal nocturnal hemoglobinuria, neutrophils express reduced leukocyte alkaline phosphatase, which is a GPI linked protein. This is because in PNH there is mutation of phosphatidylinositol glycan class A(PIGA). Mutation in PIGA result in impaired linkage of proteins with glycosyl phosphatidylinositol, thereby reducing its expression. Ref: Harrison's Principle of Internal Medicine, 18th Edition, Pages 883-884, Chapter 106 ; Diagnostic Pediatric Hematopathology By Maria A. Proytcheva, Page 86