This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Fluids and Electrolyte Imbalance, Subject name: Medicine
Which of the following genetic abnormalities is associated with the development of hyperkalemia: 
Select and explain. 
A. 11b - hydroxylase deficiency, B. Liddle's syndrome, C. Gitelman syndrome, D. Autosomal dominant polycystic kidney disease
D: Autosomal dominant polycystic kidney disease
Answer: D: Autosomal dominant polycystic kidney disease 
Explanation: 11 beta hydroxylase deficiency Androgen excess- masculinization of female newborns and precocious pubey in male Hypeension, which may or may not be associated with mineralocoicoid excess, hypokalemia, and metabolic alkalosis Liddle syndrome AD, hypeension associated with low plasma renin activity, metabolic alkalosis, hypokalemia, and normal to low levels of aldosterone Autosomal dominant polycystic kidney disease Since ESRD will ensue in these patients, hyperkalemia will always be a feature of ADPKD Gitelman syndrome Hypokalemic metabolic alkalosis