This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Thyroid Tumor, Subject name: Pathology
Orphan Annie eye nuclei appearance is characteristic of: 
Select and explain. 
A. Papillary carcinoma thyroid, B. Carcinoma pituitary, C. Paraganglioma, D. Meningioma
A: Papillary carcinoma thyroid
Answer: A: Papillary carcinoma thyroid 
Explanation: - Nuclei of papillary carcinoma cells contain finely dispersed chromatin, which impas an optically clear or empty appearance of nuclei, giving rise to designation ground-glass or Orphan Annie eye nuclei.