This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pediatrics
Causes of precocious puberty in girls are all except: 
Select and explain. 
A. Hypothalamic hamartoma, B. Hypothyroidism, C. McCune Albright syndrome, D. Prader Willi syndrome
D: Prader Willi syndrome
Answer: D: Prader Willi syndrome 
Explanation: d. Prader Willi syndrome(Ref: Nelson's 20/e p2673, Ghai 8/e p 534)Discussing about the options one by onea. Hypothalamic hamartomas that secrete excess gonadotropin-releasing hormone are responsible for a significant proportion of cases of precocious pubertyc. McCune-Albright syndrome is a cause of peripheral precocious puberty, where, cutaneous pigmentation and fibrous dysplasia of the skeletal system are also seend. In Prader Willi syndrome, there is hypogonadism; So, sexual development is delayedb. In hypothyroidism, though puberty is usually delayed in adolescents, pseudo precocious puberty may be seen in younger children, as a result of abnormally high TSH concentrations binding to FSH receptor with subsequent stimulation