This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pathology
With reference to neoplasia, the term 'tumor progression means 
Select and explain. 
A. Spread of cancer to distant sites, B. Rate of growth of tumors, C. Abi1ity of cancer cells to resemble their normal counterpa, D. Sequential appearnace of features of increasing malignancy
D: Sequential appearnace of features of increasing malignancy
Answer: D: Sequential appearnace of features of increasing malignancy 
Explanation: Multi step.theory of carcinogenesis Phy.attributes are .self sufficient in growth signal .local invasion ,metastasis .karyotic pattern .hormonal response .response to Anti malignant drugs Evading apoptosis All these acquired in a step wise fashion This phenomenon is tumour progression