This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following local anesthetic should not be mixed with adrenaline 
Select and explain. 
A. Lignocaine, B. Bupivacaine, C. Mepivacaine, D. Cocaine
D: Cocaine
Answer: D: Cocaine 
Explanation: Cocaine is a vaso constrictor by itself and hence should be avoided along with adrenaline.