This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nature of Gene Abnormalities, Subject name: Pathology
Which of the following is not a cachetic gene? 
Select and explain. 
A. APEH, B. MC4R, C. Smad7, D. Smad3
C: Smad7
Answer: C: Smad7 
Explanation: Ans is 'c' i.e. Smad 7 o Smad 7 gene delivery prevents cachexia.o Smad-3y melanocortin - 4 receptor (MC4R) and APEH (acylpeptide hydrolase) genes have been implicated in causation of cancer cachexia.