This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
Useful markers of epithelial differentiation are 
Select and explain. 
A. Fillagrin, B. Loricin, C. Both, D. None
C: Both
Answer: C: Both 
Explanation: The protein making the bulk of keratohyalin granules is fillagrin. Also sulfur-rich protein loricin is present.  Fillagrin and loricin are useful markers of epithelial differentiation. Involucrin contributes to the 'Cornified cell envelope' in the cell membrane of keratohyalin cells.