This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Anti IgE monoclonal antibody used in bronchial asthma is 
Select and explain. 
A. Mepolizumab, B. Omalizumab, C. Keliximab, D. Altrakincept
B: Omalizumab
Answer: B: Omalizumab 
Explanation: It is a humanized monoclonal antibody against IgE. Administered i.v. or s.c., it neutralizes free IgE in circulation without activating mast cells and other inflammatory cells.
In severe extrinsic asthma, omalizumab has been found to reduce exacerbations and steroid requirement.
It is very expensive; use is reserved for resistant asthma patients with positive skin tests or raised IgE levels who require frequent hospitalization.