This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Fungal Drugs, Subject name: Pharmacology
Which of the following statements about fluconazole is most accurate? 
Select and explain. 
A. It is highly effective in the treatment of aspergillosis, B. It does not penetrate the blood-brain barrier, C. Its oral bioavailability is less than that of ketoconazole, D. It inhibits demethylation of lanosterol
D: It inhibits demethylation of lanosterol
Answer: D: It inhibits demethylation of lanosterol 
Explanation: * Fluconazole (Azoles) act by inhibiting the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. * It has very good CNS penetration and oral bioavailability. * It is not very effective against aspergillosis (voriconazole is the drug of choice).