This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Considerations - Infectious Diseases, Subject name: Pediatrics
All of the following are true about Chickenpox except: 
Select and explain. 
A. Incubation period can range from 10-21 days., B. Subclinical varicella is rare, C. Simultaneous presence of lesions in various stages of evolution is characteristic, D. Umbilicated vesicles are the earliest lesions to appear
D: Umbilicated vesicles are the earliest lesions to appear
Answer: D: Umbilicated vesicles are the earliest lesions to appear 
Explanation: d. Umbilicated vesicles are the earliest lesions to appear(Ref: Nelson 20/e p1580-1581)Initial exanthem in Chicken pox consists of pruritic erythematous macules that evolve through papular stage to form clear, fluid- filled vesicles. Clouding & umbilication of the lesions begin in 24-48 hr.Simultaneous presence of lesions in various stages of evolution is characteristic of varicella.Distribution of rash is predominantly centripetal with greatest concentration on trunk.