This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Hepatomegaly is an essential feature of 
Select and explain. 
A. Von Gierke's disease, B. Nieman Pick disease, C. Hurler syndrome, D. Hepatic porphyria
D: Hepatic porphyria
Answer: D: Hepatic porphyria 
Explanation: Hepatomegaly is an essential feature of von Gierke's disease (all glycogen storage diseases except type 2, 5, 7), Hurler (Scheic) syndrome (& all mucopolysaccharidosis) and Nieman-Pick disease. But the hepatic involvement of hepatic porphyria is variable. Patients with chronic hepatic porphyria (porphyria cutanea tarda), however may show liver enlargement d/t fatty infiltration but frank sings of hepatomegaly and iron overload are rare.