This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pancreas, Subject name: Pathology
Most common gene associated with pancreatic cancer 
Select and explain. 
A. KRAS, B. SMAD, C. P53, D. Rb
A: KRAS
Answer: A: KRAS 
Explanation: Ans. (a) KRAS(Ref Robbins 9th/pg 892-894)GeneChrPercentage KRAS12p90Most commonly involved Oncogene Qp16/CDKN2A9p95Most commonly involved Tumor suppressor gene QTP5317p50-70Involved in Response to DNA damageSMAD418q55TGF b pathwayBRCA213q10Germ-line mutation Q