This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Mutation in which of the following tumour suppressor gene causes carcinoma? 
Select and explain. 
A. p53, B. p51, C. Ro, D. All of the above
A: p53
Answer: A: p53 
Explanation: If the p53 gene is mutated, the protection offered by the p53 tumor suppressor protein against DNA damage (for example, ras oncogene mutation) is lost. If a cell becomes homozygous for the mutant allele, that is ‘loses heterozygosity’, cancer may develop.
Ref: Shafer's textbook of oral pathology 7th edition page 108