This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Antibody associated with cold antibody immunohemolytic anemia is: 
Select and explain. 
A. IgA, B. IgE, C. IgG, D. IgM
D: IgM
Answer: D: IgM 
Explanation: Cold antibody immunohemolytic anemia usually is caused by low-affinity IgM antibodies that bind to red cell membranes only at temperatures below 30°C, occurs in distal parts of the body (e.g., ears, hands, and toes) in cold weather.
 Warm antibody immunohemolytic anemia is caused by immunoglobulin G (IgG) or (rarely) IgA antibodies that are active at 37°C.