This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Genetic analysis is done a patient which showed a loss of function mutation in a gene that leads to accumulation of misfolded proteins. which of the following biochemical process is most likely affected 
Select and explain. 
A. Glucuronidation, B. Ubiquitination, C. Acetylation, D. Phosphorylation
B: Ubiquitination
Answer: B: Ubiquitination 
Explanation: Ubiquitination is a ATP dependent pathway for protein degradation. Impairment of this process leads to accumulation of misfolded proteins.