This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T., Subject name: Medicine
A 52-year-old woman is experiencing abdominal discomfort after meals as well as early in the morning. There is no weight loss or constitutional symptoms, and she has tried antacids but experiences minimal relief. Upper endoscopy reveals a duodenal ulcer and the biopsy is negative for malignancy. Which of the following is the most appropriate next step in management? 
Select and explain. 
A. 6-8 weeks of omeprazole or ranitidine, B. long-term acid suppression with omeprazole, C. antibiotic therapy, D. antibiotic therapy and omeprazole
D: antibiotic therapy and omeprazole
Answer: D: antibiotic therapy and omeprazole 
Explanation: Antibiotic therapy for eradication of H pylori in combination with acid suppression with a proton pump inhibitor like omeprazole is the most effective treatment for duodenal ulcer disease. The most popular regimes include antibiotics and acid suppression medications.