This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gynaecology, Subject name: Gynaecology & Obstetrics
18 year old girl with primary amenorrhea having a karyotype of 45X0 presents with infantile uterus. What should be done next? 
Select and explain. 
A. B/L gonadectomy, B. H to induce pubey, C. Clitoroplasty, D. Vaginoplasty
B: H to induce pubey
Answer: B: H to induce pubey 
Explanation: Primary amenorrhea with karyotype of 45 XO with an infantile uterus is suggestive of TURNER SYNDROME Management Screen for associated abnormalities: cardiac (30% have coarctation of aoa), renal (esp.horseshoe kidney), autoimmune abnormalities (thyroiditis), diabetes, hypeension and hearing loss Growth hormone therapy: accelerate growth velocity and improves final height Gonadal steroids: sta with estrogen therapy and add progesterones to induce pubey