This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Resistance to drugs in Tuberculosis develops by - 
Select and explain. 
A. Transduction, B. Conjugution, C. Transformation, D. Mutation
D: Mutation
Answer: D: Mutation 
Explanation: Ans. is 'd' i.e., Mutation o The most common mechanism of antitubercular drugs resistance is by mutation - INH --> Catalase - peroxidase gene (Kat G) or inh A gene. Rifampin --> rpo B gene PZA --> pnc A gene ETB --> emb B gene Streptomycin --> 16 S rRNA gene (rrs) or ribosomal protein S-12 gene (rpst).