This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
What should be measured in a newborn who presents with hyperbilirubinemia – 
Select and explain. 
A. Total & Direct bilirubin, B. Total bilirubin only, C. Direct bilirubin only, D. Conjugated bilinibin only
A: Total & Direct bilirubin
Answer: A: Total & Direct bilirubin 
Explanation: Bilirubin is a tetrapyrrole and a breakdown product of heme catabolism.
Most bilirubin (70%-90%) is derived from hemoglobin degradation and, to a lesser extent, from other hemoproteins. In the serum, bilirubin is usually measured as both direct bilirubin (DBil) and total-value bilirubin
Direct bilirubin correlates with conjugated bilirubin but tends to overestimate actual conjugated bilirubin, as it includes both the conjugated bilirubin and bilirubin covalently bound to albumin (delta-bilirubin).
Indirect bilirubin correlates with unconjugated bilirubin but tends to underestimate unconjugated bilirubin, as a