This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
Role of insulin in type 2 DM - 
Select and explain. 
A. Acute illness, B. Polyurea, C. Secondary OHA failure, D. Obese patient
A: Acute illness
Answer: A: Acute illness 
Explanation: Insulin should be considered as the initial therapy in type 2 DM, paicularly in lean individuals or those with severe weight loss, in individuals with underlying renal or hepatic dis- ease that precludes oral glucose-lowering agents, or in individuals who are hospitalized or acutely ill. Insulin therapy is ultimately required by a substantial number of individuals with type 2 DM because of the progressive nature of the disorder and the relative insulin deficiency that develops in patients with long-standing diabetes. Reference : page 2415 Harrison&;s Principles of Internal Medicine 19th edition