This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy: General Principles, Subject name: Pharmacology
True about aminoglycosides is all except. 
Select and explain. 
A. Are bacteriostatic, B. Distributed only extracellularly, C. Excreted unchanged in urine, D. Teratogenic
A: Are bacteriostatic
Answer: A: Are bacteriostatic 
Explanation: Ans. (A) Are bacteriostatic(Ref: KDT 8/e p793)The aminoglycosides are bactericidal antibiotics.They are more active at alkaline pH.They kill the bacteria by interfering with protein synthesis.They are distributed only extracellularly so the volume of distribution is nearly equal to the extracellular fluid volume.They are not metabolized, they are excreted unchanged in the urine.Aminoglycosides should be avoided during pregnancy because these can cause fetal damage (teratogenic)