This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Kalli, 35yrs old female presents with Bilateral deep vein thrombosis in legs. There is past history of recurrent foetal loss and one attack of pulmonary embolism. Screening tests of coagulation reveal a prolonged aPTT. Likely diagnosis is: 
Select and explain. 
A. Factor VIII deficiency, B. Inherited Protein C and S deficiency, C. Anti phospholipid syndrome, D. Hereditary excess of Anti thrombin III
C: Anti phospholipid syndrome
Answer: C: Anti phospholipid syndrome 
Explanation: A female with history of deep vein thrombosis in legs, recurrent foetal loss and one attack of pulmonary embolism with prolonged aPTT highlights the diagnosis of a hypercoagulable state which is anti phospholipid syndrome. Ref: Hughes Syndrome: Antiphospholipid Syndrome By Munther A. Khamashta, 2006 ; Textbook of Obstetrics By Dutta, 6th Edition, Page 343 ; Williams Obstetrics, 21st Edition, Page 1390