This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following act as a tumour suppressor gene? 
Select and explain. 
A. Myc, B. Fos, C. Ras, D. Rb
D: Rb
Answer: D: Rb 
Explanation: Tumor suppressor genes regulate cell growth. Rb gene was the first tumor suppressor gene discovered. In the active state Rb gene serve as a brake on the advancement of cells from the G1 to the S phase of cell cycle. Rb gene located on chromosome 13, when mutated results in retinoblastoma. Ref: Robbins Pathologic Basis of Disease, 6th Edition, Page 287