This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Irreversible cell injury is indicated by - 
Select and explain. 
A. Accumulation of calcium in mitochondria, B. Myelin figures, C. ATP depletion, D. Shifting of ribosomes
A: Accumulation of calcium in mitochondria
Answer: A: Accumulation of calcium in mitochondria 
Explanation: Ans. is 'a' i.e., Accumulation of calcium in mitochondrion Large, flocculant, amorphous densities in mitochondrial matrix develop due to increased Ca+2 influx. Note : o Small (not large) phospholipid rich amorphous densities are found in reversible injury.