This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology and Rheumatology, Subject name: Medicine
Which is the best treatment in a case of PNH presenting with black colour urine? 
Select and explain. 
A. Eculizumab, B. Rituximab, C. Infliximab, D. Prednisolone
D: Prednisolone
Answer: D: Prednisolone 
Explanation: Ans. D. PrednisoloneTreatment:Best Initial treatment to control Hemolysis = PrednisoloneBest treatment = BMTBest treatment to prevent chronic hemolysis or clot formation = Eculizumab:Eculizumab is a monoclonal antibody that specifically binds to the complement protein C5, thus inhibiting terminal complement mediated intravascular hemolysis in PNH patients.