This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Sulfonylureas act by: 
Select and explain. 
A. Decreasing glucagon secretion from pancreas, B. Decreasing insulin secretion from pancreas, C. Increasing gluconeogenesis, D. Increasing insulin secretion from pancreas
D: Increasing insulin secretion from pancreas
Answer: D: Increasing insulin secretion from pancreas 
Explanation: Ans. (D) Increasing insulin secretion from pancreas(Ref: KDT 8/e p294)Sulfonylureas stimulate the release of insulin by the beta cells of the islets of Langerhans by blocking K+ channels. Glucagon secretion is also reduced by sulfonylureas, but it is a minor action.