This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Which of the following regarding sickle cell disease is false? 
Select and explain. 
A. Single nucleotide change results in change of Glutamine to Valine, B. Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue, C. HbS provides resistance against malaria, D. Binding of deoxyHbA terminates fiber polymerization
B: Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue
Answer: B: Sticky patch is generated as a result of replacement of a nonpolar residue with a polar residue 
Explanation: In HbS, the nonpolar amino acid valine has replaced the polar surface residue Glu6 of the β subunit, generating a hydrophobic “sticky patch” on the surface of the β subunit of both oxyHbS and deoxyHbS.
Ref: Harper’s illustrated biochemistry. 30th edition page no: 56