This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Hyperkeratosis of palm and sole is seen in: 
Select and explain. 
A. Carcinoma colon, B. Hepatoma, C. Adenocarcinoma lung, D. Ca oesophagus
D: Ca oesophagus
Answer: D: Ca oesophagus 
Explanation: Answer is D (Ca Esophagus) Congenital hyperkeratosis and pitting of palms and soles (Le tylosis palmaris et plantaris) is a known etiological factor for squamous Ca of Esophagus' - Harrison