This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other Autoimmune Disorders, Subject name: Pathology
Which antibody is a/w the condition showing following features? 
Select and explain. 
A. Anti ds. DNA, B. Anti-Ro, C. Anti CCP, D. Anti SCL - 70
D: Anti SCL - 70
Answer: D: Anti SCL - 70 
Explanation: Systemic Sclerosis (Scleroderma) Characterized by vascular injury and progressive perivascular and interstitial fibrosis of multiple organs. Females>Males with age group is 30 to 50 years. Cutaneous involvement is most common. Etiology and pathogenesis Microvascular injury is a hallmark feature of systemic sclerosis. Two clinical categories are: Diffuse scleroderma: Widespead cutaneous involvement. It has two Auto-antibodies: Anti-topoisomerase I (anti-Scl-70) antibodies are specific. RNA polymerase III antibodies.