This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
Hypervitaminosis E leads to: 
Select and explain. 
A. Hypercalcemia, B. Raised intracranial tension, C. Increased bleeding time, D. Psychosis
C: Increased bleeding time
Answer: C: Increased bleeding time 
Explanation: Vitamin E is believed to inhibit protein kinase C-mediated platelet aggregation and nitric oxide production In patients with unexplained bruising or bleeding, it is impoant to review vitamin E supplementation. Extra Edge: Fish oil is also contraindicated in patients with bleeding tendencies.