This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The radiograph of skull is suggestive of which of the following diagnosis ? 
Select and explain. 
A. Malignant melanoma, B. Multiple myeloma, C. Sickle cell anemia, D. Langerhans cell histiocytosis
C: Sickle cell anemia
Answer: C: Sickle cell anemia 
Explanation: Radiograph of a patient with sickle cell anemia showing a thickened diploic space and thinning of the skull cortex. Skull showing the hair-on end bone pattern.