This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anaesthesia, Subject name: Pharmacology
Pancuronium differs from tubocurarine in that: 
Select and explain. 
A. It is a depolarizing blocker, B. Its action is not reversed by neostigmine, C. It can cause rise in BP on rapid I.V. injection, D. It causes marked histamine release
C: It can cause rise in BP on rapid I.V. injection
Answer: C: It can cause rise in BP on rapid I.V. injection 
Explanation: * Pancuronium possesses vagolytic activity and can cause hypeension and tachycardia on rapid i.v. injection. * Pancuronium is a competitive NM blocker (Non-depolarizing NM blocker). Its actions can be reversed by anticholinesterases like neostigmine. * Unlike d-TC, histamine release is not seen with pancuronium.