This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Monotherapy with which of the following antidiabetic drug can cause hypoglycemia? 
Select and explain. 
A. Metformin, B. Gliclazide, C. Piogiltazone, D. All of the above
B: Gliclazide
Answer: B: Gliclazide 
Explanation: Gliclazide belongs to sulphonyluread. It has higher incidence of hypoglycemia. metformin and glitazones- no hypoglycemia risk (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 268)