This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Maintainance dose of drug is dependent on ? 
Select and explain. 
A. Half life, B. Volume of distribution, C. Total body concentration, D. Loading dose
A: Half life
Answer: A: Half life 
Explanation: Ans. is 'a' i.e., Half life Loading dose is governed by volume of distribution. Maintenance dose is governed by clearance or P/2. The drug with sho t1/2 with loading and maintenance dose concept - Lignocaine.