This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Histamine, 5-HT and PGs, Subject name: Pharmacology
A 19-year-old male complains of Shoness of breath associated with wheezing after he takes aspirin for headache. In cases of aspirin hypersensitivity, which of the following mediators will be responsible for above mentioned condition? 
Select and explain. 
A. Leukotriene LTC4, B. PGE2, C. Prostacyclin, D. Thromboxane
A: Leukotriene LTC4
Answer: A: Leukotriene LTC4 
Explanation: Aspirin act by inhibiting PG synthesis by cyclo-oxygenase pathway, so PG precursors are diveed to form leukotrienes in the lipoxygenase pathway. In patients having aspirin hypersensitivity, this leads to bronchoconstriction and shoness of breath.