This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Which of the following is associated with PAS positive macrophages? 
Select and explain. 
A. Whipple disease, B. Abetalipoproteinemia, C. Crohns disease, D. Ulcerative colitis
A: Whipple disease
Answer: A: Whipple disease 
Explanation: Ref. Robbins Pathology. 9th edition. Page. 791
 
Whipple disease:

Rare systemic infection due to Tropheryma whippelii, a gram positive intracellular actinomycete
Usually affects proximal intestine, mesenteric lymph nodes
Also called intestinal lipodystrophy

 
Symptoms:

Malabsorption with diarrhea, weight loss, abdominal pain
Occasionally polyarthritis, CNS complaints, lymphadenopathy, hyperpigmentation
Cardiac involvement less common

 
Microscopy

Distended macrophages in lamina propria containing PAS+ (diastase resistant) granules and rod shaped bacilli by EM
Dilated lymphatics or fat vacuoles