This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Osteochondritis and Avascular Necrosis, Subject name: Orthopaedics
Which of the following statements about changes in aicular cailage with ageing is not true: 
Select and explain. 
A. Total proteoglycan content is decreased, B. Synthesis of proteogycans is decreased, C. Enzymatic degradation of proteoglycans is increased, D. Total water content of cailage is decreased
C: Enzymatic degradation of proteoglycans is increased
Answer: C: Enzymatic degradation of proteoglycans is increased 
Explanation: Cailage propey Aging Osteoahritis Hydration Decreased Increased ( in late OA its also decreased) Proteolytic enzymes Normal Increased Proteoglycan content Decreased(due to decreased synthesis) Decreased (due to increased destruction)