This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
A 45-year-old man develops end-stage renal disease due to diabetic nephropathy. He undergoes a renal transplant with a kidney donated from his sister. Which of the following immune suppression therapies are usually used to prevent rejection in renal transplant patients? 
Select and explain. 
A. splenectomy and irradiation, B. plasmapheresis and steroids, C. cyclosporine and steroids, D. azathioprine and plasmapheresis
C: cyclosporine and steroids
Answer: C: cyclosporine and steroids 
Explanation: Cyclosporine A blocks production of inter-leukin-2 (IL-2) by helper-inducer (CD4+) T cells. It works alone but is more effective in combination with glucocorticoids. The use of cyclosporine has improved 1-year cadaveric survival rates to the 80%-85% range. Side effects include hepatotoxicity, hirsutism, tremor, and gingival hyperplasia, but only the nephrotoxicity presents a serious management problem.