This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
Aplastic anemia is characterized by all EXCEPT 
Select and explain. 
A. Pancytopenia, B. Moderate size spleen enlargement, C. Hypocellular bone marrow, D. Thrombocytopenia
B: Moderate size spleen enlargement
Answer: B: Moderate size spleen enlargement 
Explanation: B. i.e. (Moderate size spleen enlargement (439 - Basic pathology 8th)* "Splenomegaly is characteristically absent in Aplastic anemia". Lymphnode, liver are not enlargedAPLASTIC ANEMIA - in which multipotent myeloid stem cells are suppressed leading to marrow failure and pancytopenia.* *Haemorrhage from various sites due to thrombocytopenia such as from the skin, nose, gums, vagina, bowel and occasionally in the CNS and retina* Normocytic normochromic anemia* Reticulocytes count is reduced or zero* *Leucopenia, neutrophils are morphologically normal alkaline phosphatase score is high*** **Hypocellular bone marrowSpur cell anemia is caused by chronic liver disease**