This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2019, Subject name: Psychiatry
Intense depression & misery without any cause is? 
Select and explain. 
A. Melancholia, B. Major depressive disorder, C. Mania, D. Schizophrenia
A: Melancholia
Answer: A: Melancholia 
Explanation: Melancholic depression - A. Prominent biological symptom 1. Early morning awakening (waking up at least 2 hours before usual time) 2.Significant anorexia and weight loss. B. Significant psychomotor agitation or retardation. C. Anhedonia and lack of mood reactivity.(the patients mood doesn't improve even if some positive event occurs ) D. A distinct quality of intensely depressed mood, often referred to as a state of despondency or despair,also called empty mood.the patients feels miserable. E. Depression is worse in morning. F. Excessive guilt.