This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
Which of the following is a new drug that acts by inhibiting PCSK9? 
Select and explain. 
A. Reslizumab, B. Brodalumab, C. Alirocumab, D. Ixekizumab
C: Alirocumab
Answer: C: Alirocumab 
Explanation: Monoclonal Antibodies that target PCSK9: Alirocumab and Evolocumab. Pro protein convease subtilisin Kexan type 9 (PCSK9) is a protein that binds LDL receptors and transpo them to lysosomes where these are degraded . Therefore instead of recycling of LDL receptor to surface of hepatocytes they get destroyed. Inhibitors of PCSK9 therefore prevent destruction of LDL receptor resulting in lowering of LDL cholesterol.