This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other hea diseases in children, Subject name: Pediatrics
Most common gene involved in Noonan syndrome 
Select and explain. 
A. PTCN 11, B. PTPN 11, C. PTPN 22, D. PTCN 22
B: PTPN 11
Answer: B: PTPN 11 
Explanation: NOONAN SYNDROME: - Autosomal dominant, Normal karyotype - MC gene involved --> PTPN 11 - Seen in both boys & girls --> FEILE - FEATURES: Sho stature webbed neck Anti-mongoloid slant eyes (Opposite of Down syndrome) Cubitus valgus Clinodactyly, Cryptorchidism cardiac anomalies: Supra valvular Pulmonary Stenosis -->, HOCM, ASD Presence of Intellectual disability