This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pediatrics
Testes are not palpable in 
Select and explain. 
A. SRY deletion, B. DAX 1 deletion, C. WNT4 gene mutation, D. RSPO1 gene mutation
A: SRY deletion
Answer: A: SRY deletion 
Explanation: WT-1 and SF-1 genes stimulate genital ridge to form primitive (bipotential) gonad which then differentiates either into ovary or testis.SRY genes involved in the development of male gonads (testes) from primitive (bipotential gonads)DAX-1, WNT-4, and RSPO1 genes are involved in the development of female gonads (ovary)(Refer: Nelson's Textbook of Pediatrics, SAE, 1st edition, pg no. 2730)