This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory chain, Subject name: Biochemistry
Uncoupler in ETC 
Select and explain. 
A. H2S, B. Antimycin a, C. 2, 4-dinitrophenol, D. Barbiturates
C: 2, 4-dinitrophenol
Answer: C: 2, 4-dinitrophenol 
Explanation: Dinitrophenol (DNP) a potent uncoupler is amphipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation.Ref: MN Chatterjea Textbook of Medical Biochemistry, 8th edition, page no: 146