This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Irreversible cell Injury/Necrosis, Subject name: Pathology
Which of the following processes involve caspase 1 and 11 activation? 
Select and explain. 
A. Necrosis, B. Necroptosis, C. Apoptosis, D. Pyroptosis
D: Pyroptosis
Answer: D: Pyroptosis 
Explanation: Pyroptosis isa highly inflammatory form of programmed cell death that occurs in cells infected by microbes. It involves activation of caspase-1 which cleaves the precursor form of IL-1 to generate biologically active IL-1. Caspase-1 along with closely related caspase-11 also cause death of the infected cell. Necroptosis: - It is a caspase independent programmed cell death. Apoptosis: -. The mitochondrial pathway (Intrinsic)leads to activation of the initiator caspase-9, and the death receptor pathway (Extrinsic) to the initiator caspases-8 and 10.