This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
In a patient with liver cirrhosis, where does poal vein obstruction occur? 
Select and explain. 
A. Poal vein, B. Splenic vein, C. Sinusoids, D. Hepatic vein
C: Sinusoids
Answer: C: Sinusoids 
Explanation: In cirrhosis of the liver, poal vein obstruction occur at the level of sinusoids. In cirrhosis there is fibrosis of the liver resulting in architectural distoion with the formation of regenerative nodules. This results in a decrease in hepatocellular mass, its function, and an alteration of blood flow. Complications of cirrhosis includes poal hypeension and its consequences (such as gastroesophageal variceal hemorrhage, splenomegaly, ascites), hepatic encephalopathy, spontaneous bacterial peritonitis (SBP), hepatorenal syndrome, and hepatocellular carcinoma. Ref: Harrison's Internal Medicine, 18th Edition, Page 2598, Chapter 308