This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
Which of the following substance is used as biological therapy for malignant melanoma? 
Select and explain. 
A. IL-2, B. Infliximab, C. Etanercept, D. All of the above
A: IL-2
Answer: A: IL-2 
Explanation: Interleukin-2 and interferon are two examples of BRMs being tested for the treatment of advanced malignant melanoma. Etanercept(Enbrel) and infliximab(Remicade) are examples of commercially available injectable TNF-blocking treatments for patients with severe rheumatoid ahritis.