This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anesthesia, Subject name: Pharmacology
True statement about Sevoflurane is 
Select and explain. 
A. It is nephrotoxic at high doses, B. It has maximum risk of causing convulsions, C. It is cardiostable, D. It can cause fulminatnt hepatitis
A: It is nephrotoxic at high doses
Answer: A: It is nephrotoxic at high doses 
Explanation: Refer Goodman Gilman 11/e p 360 Sevoflurane is a general anesthetic used by inhalation route It is very good agent for children and asthmatic patients It can produce dose dependent hypotension and decrease in cardiac output It high doses it can release fluoride resulting min Nephrotoxicity