This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which one of the following is an adverse effect associated with combined oral contraceptives ? 
Select and explain. 
A. Cerebral stroke, B. Aggravation of asthma, C. Peripheral neuropathy, D. Nephrotic syndrome
A: Cerebral stroke
Answer: A: Cerebral stroke 
Explanation: Ans. is 'a' i.e., Cerebral stroke Impoant adverse effects of OCPs are : (1) Nausea, vomiting, headache (worsening of migraine), (2) breakthrough bleeding, (3) mastalgia, (4) weight gain, (5) acne and hirsutism, (6) cholasma and pruritis, (7) carbohydrate intolerance, (8) leg vein and pulmonary thrombosis, (9) coronary and cerebral thrombosis (MI & stroke), ( 10) hypeension, (11) increased risk of breast and cervical carcinoma, (12) benign hepatoma, (13) gall stones, (14) precipitation of acute intermittent porphyria.