This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chronic Kidney Disease and Uremia, Subject name: Medicine
Most common cause of End stage renal disease is: 
Select and explain. 
A. Diabetes, B. Hypertension, C. Chronic GN, D. Polycystic Kidney disease
A: Diabetes
Answer: A: Diabetes 
Explanation: Ref: Harrison's Principles of Internal Medicine. 18ed.Explanation:The dispiriting term end-stage renal disease' should not be used and is replaced by the term stage 5 CKD"The most frequent cause of CKD is diabetic nephropathy. most often secondary to type 2 diabetes melli- tus Ref: HarrisonLeading Categories of Etiologies of CKDDiabetic glomerular disease (MC Cause)GlomerulonephritisHypertensive nephropathyPrimary glomerulopathy with hypertensionVascular and ischemic renal diseaseAutosomal dominant polycystic kidney diseaseOther cystic and tubulointerstitial nephropathy