This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Alcohol in substrate inducer for which gene? 
Select and explain. 
A. Pol III gene, B. Myc Oncogene, C. P53, D. NF1
A: Pol III gene
Answer: A: Pol III gene 
Explanation: Ans. is 'a' i.e., Pol III gene Alcohol induces pol III gene (RNA polymerase III-dependent genes) transcription in vivo and in vitro. Brfl specifically regulates pol III gene transcription. Changes in pol III gene and Brfl expression tightly link to cell transformation and tumor formation. Alcohol induced deregulation of pol III genes may be fundamental to the development of breast cancer.