This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which of the following is not a major criteria for diagnosis of multiple myeloma? 
Select and explain. 
A. Lytic bone lesions, B. Plasmacytoma on tissue biopsy, C. Bone marrow plasmacytosis > 30%, D. M' spike > 3g% for Ig G, > 2g% for IgA
A: Lytic bone lesions
Answer: A: Lytic bone lesions 
Explanation: "Lytic bone lesions" is not a major criteria for the diagnosis of multiple myeloma. It is a minor criteria for the diagnosis of multiple myeloma. So "Lytic bone lesions" is the single best answer of choice. Ref: The Washingtom Manual of Surgical Pathology: Depament of Pathology By Peter A Humphrey, Loius P.Dehner, Ohn D. Pfeifer, Page 565.