This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Antimicrobial Drugs, Subject name: Pharmacology
Most impoant mechanism of development of resistance to drugs in tuberculosis is 
Select and explain. 
A. Transduction, B. Conjugation, C. Transformation, D. Mutation
D: Mutation
Answer: D: Mutation 
Explanation: Most impoant mechanism of development of resistance to anti-tubercular drugs is mutation. DRUG RESISTANCE MUTATION IN GENE Rifampicin rpoB Isoniazid katG and inhA Ethambutol embB Pyrazinamide pncA