This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
What happens to hepcidin levels in Anemia of chronic disease 
Select and explain. 
A. Increases, B. Decreases, C. Remains normal, D. Any of the above
A: Increases
Answer: A: Increases 
Explanation: In anemia of chronic disease due to release of cytokines IL-6, TNF-α, IL - 1, (as a result of chronic inflammation) hepcidin synthesis increases in the liver.
Hepicidin inhibits iron release from macrophages.