This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Hypospadias in the baby is caused by maternal use of which of the following drug? 
Select and explain. 
A. Diethylstilbestrol, B. Tolbutamide, C. Clomiphene, D. Clobazam
C: Clomiphene
Answer: C: Clomiphene 
Explanation: Clomiphene is antiestrogens. It can cause hypospadias in the baby- in which the opening of the urethra is on the underside of the penis instead of at the tip Clomiphene, a drug used to induce ovulation, is chemically related to diethylstilbestrol (DES). DES is associated with vaginal adenocarcinoma among daughters and with hypospadias among second-generation male offspring. (REF. Essentials of medical pharmacology K D TRIPATHI 6 Edition, Page No 312)