This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gastro-Intestinal Tract, Subject name: Pharmacology
Drug of choice for the treatment of peptic ulcer caused due to chronic use of NSAIDs is: 
Select and explain. 
A. Pirenzepine, B. Loxatidine, C. Misoprostol, D. Esomeprazole
D: Esomeprazole
Answer: D: Esomeprazole 
Explanation: Proton pump inhibitors: are DOC for :-- PUD of any reason- GERD- Zollinger Ellison Syndrome Misoprostol is specific drug for NSAIDs induced peptic ulcer.