This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Epidemiology, Subject name: Social & Preventive Medicine
Which vaccine causes ITP as an adverse effect? 
Select and explain. 
A. MMR, B. Typhoid vaccine, C. Influenza vaccine, D. HIB
B: Typhoid vaccine
Answer: B: Typhoid vaccine 
Explanation: .the type 21a vaccine for typhoid fever is relatively wll tolerated and has low rates of adverse effects.but it is not recommended in congenital or acquired immunodeficiency including treatment with immunosuppressive and antimitotic drugs,acute febrile illness and acute intestinal ifections.typhoid vaccines are also known to produce idiopathic thrombocytopenic purpura,(ITP) at times for which proper clinical evidences are lacking. ref:park&;s textbook,22 nd ed,pg 216