This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Type II hypersensitivity is mediated by - 
Select and explain. 
A. Complimented mediated, B. Antibody mediated, C. Immune complex mediated, D. Cell mediated
B: Antibody mediated
Answer: B: Antibody mediated 
Explanation: Antibody mediated 


Type I reactions (immediate hypersensitivity) → Involve immunoglobulin ‘E’(Ig E) mediated release of Histamin and other mediators from mast cells and basophils.
Type II reactions (Antibody mediated) → Involve immunoglobulin Gor Immunoglobulin Mbound to cell surfac antigen, with subsequent complement fixation.
Type III reactions (Immune complex mediated) → involve circulating antigen-antibody complexes that deposit ii postcapillary venules, with subsequent complement fixation.
Type IV reactions (delayed hvpersensititv. cell mediated) → Mediated by Tcells.