This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General obstetrics, Subject name: Gynaecology & Obstetrics
A couple with a child of spina bifida comes for preconceptional counseling. what is the recurrence risk of spina bifida in this couple? 
Select and explain. 
A. 3-5%, B. 5-10%, C. 10%, D. >10%
A: 3-5%
Answer: A: 3-5% 
Explanation: The recurrence risk is approximately 3 to 5 percent if a couple has previously had a child with either anencephaly or spina bifida.5 percent if either parent was born with an NTD, and as high as 10 percent if a couple has two affected children. Impoantly, almost 95 percent of NTDs develop in the absence of a family history.Reference: William's obstetrics; 25th edition; Chapter 14; Prenatal Diagnosis