This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Amino Acid Metabolic Disorder, Subject name: Biochemistry
Ochronosis is due to deficiency of - 
Select and explain. 
A. Kynureninase, B. Tyrosine hydroxylase, C. Homogentisate oxidase, D. Tyrosinase
C: Homogentisate oxidase
Answer: C: Homogentisate oxidase 
Explanation: Ans. is 'c' i.e., Homogentisate oxidase Metabolic diseaseEnzyme deficientMaple syrup urine diseaseMethyl-melonic aciduriaSweaty feet odor in bodyTyrosinemia I (Tyrosinosis)Tyrosinemia IINeonatal tyrosinemiaAlbinismBranched chain ketoacid dehydrogenaseMethyl-malonyl CoA mutase (isomerase)Isovaleryl-CoA dehydrogenaseFumarylacetoacetate hydroxylaseTyrosine transaminase (Tyrosine aminotransferase)Hydroxyphenyl pyruvate hydroxylaseTyrosinaseAlkaptonuriaPhenylketonuria Orotic aciduria Homocystinuria Lesh-Nyhan syndrome CystinosisHomogentisate oxidasePhenylalanine hydroxylaseOMP decarboxylaseCystathionine synthataseComplete deficiency of enzyme HGPRTCystine reductaseNote: Ochronois is alkaptonuria.