This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Anaplasia in Wilm's tumor is evident by - 
Select and explain. 
A. Increased mitosis, B. Pleomorphic nuclei, C. Large nucleus, D. All
D: All
Answer: D: All 
Explanation: Ans. is 'a' i.e., Increased mitosis; 'b' i.e., Pleomorphic nuclei;'c'i.e., Large nucleus o It is very simple. Anaplasia (anywhere) is characterized by :- i) Loss of polarity ii) Hyperchromasia iii) Increased nuclear cytoplasmic cell ratio (increased nucleus size) iv) Pleomorphism v) Increased number of mitosis which is atypical o The presence of anaplasia in Wilm's tumor correlated with underlyingp53 mutations and emergence of resistance to chemotherapy.