This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
First antibody to appear in plasma/blood in acute hepatitis B is? 
Select and explain. 
A. Ig M Anti HBc, B. Ig M Anti HBc, C. Anti HBs, D. Anti HBe
A: Ig M Anti HBc
Answer: A: Ig M Anti HBc 
Explanation: Ig M Anti HBc REF: Harrison's 17ed chapter 298, markers See APPENDIX-28 for "MARKERS OF HEPATITIS-B"