This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulators, Subject name: Pharmacology
Which of the following immunosuppressant drugs is most nephrotoxic? 
Select and explain. 
A. Azathioprine, B. Cyclophosphamide, C. Mycophenolate mofetil, D. Tacrolimus
D: Tacrolimus
Answer: D: Tacrolimus 
Explanation: Among the given drugs Tacrolimus has dose-limiting nephrotoxicity In addition, it can precipitate diabetes, alopecia, and diarrhea. Hypeension, hirsutism, gum hyperplasia is less marked compared to cyclosporin. Other drugs listed above are antiproliferative drugs. These have no excess nephrotoxicity effect. they act mainly by preventing the clonal expansion of T and B Lymphocytes. ESSENTIALS OF MEDICAL PHARMACOLOGY SEVENTH EDITION -K.D TRIPATHI Page:881,882 ,883