This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In which of the following conditions, Aniridia and Hemihyperophy are most likely present ? 
Select and explain. 
A. Neuroblastoma, B. Wilms' tumour, C. Non-Hodgkin's lymphoma, D. Germ cell tumour
B: Wilms' tumour
Answer: B: Wilms' tumour 
Explanation: Ans. is 'b' i.e.,Wilm's tumour Wilm's tumour is associated with three groups of congenital malformations. o The risk of Wilm's tumour is increased in these conditions. o These are ? WAGR syndrome - It consists of o Aniridia o Mental retardation o Genital anomalies The risk of Wilm's tumour is increased by 33% in this syndrome. Denys - Drash syndrome - It consists of o Gonadal dysgenesis (male pseudohermaphroditism) o Nephropathy leading to renal failure. Majority of patients with this syndrome have ranal failure. Beckwith - Wiedeman syndrome - It consists of o Enlargement of body organs o Renal medullary cysts. o Hemihyperophy o Abnormal large cells in adrenal coex.