This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunodeficiency, Subject name: Microbiology
Severe combined immunodeficiency is seen with: 
Select and explain. 
A. Pre B- Cell, B. Pre T Cell, C. Both, D. NK Cell
C: Both
Answer: C: Both 
Explanation: Ans. (c) BothRef Microbiology by Ananthanaray an and Paniker 9th ed. 174* Severe combined immunodeficiency (SCID) syndrome has impairment of both humoral and cell mediated immunity (B and T cell defect).* Inheritance pattern of SCID is X-Iinked recessive > Autosomal recessive.Clinical Manifestation of SCID* Oral candidiasis in infants* Recurrent infection with candidia albicans, RCarinii, CMV, varicella.* Organs like lymph nodes, tonsils, peyers patches are absent.* Very small thymus gland* Poor survival rate.