This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
Causes for reduced bioavailability include: 
Select and explain. 
A. High first pass metabolism, B. Increased absorption, C. IV drug administration, D. High lipid solubility
A: High first pass metabolism
Answer: A: High first pass metabolism 
Explanation: Ans. (A) High first pass metabolism(Ref: KDT 8th/e p22)The causes of low bioavailability are:1. Reduced absorption2. High first pass metabolism