This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
Which of the following statements about Fluconazole is most accurate 
Select and explain. 
A. It is it effective in the treatment of Aspergillosis, B. It does not penetrate the blood brain barrier, C. It's oral bioavailability is less than that of ketoconazole, D. It inhibits demethylation of lanosterol
D: It inhibits demethylation of lanosterol
Answer: D: It inhibits demethylation of lanosterol 
Explanation: Ref-KDT 6/e p761 Azoles act by inhibiting the enzyme lanosterol-14-alpha-demethvlase.resulting in reduced ergosterol synthesis. It has very good CNS penetration and oral bioavailability. It is not very effective against aspergillosis (voriconazole is thedrug of choice).