This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Specific antibody associated with primary biliary cirrhosis is: 
Select and explain. 
A. Anti-myosin, B. Anti-nuclear, C. Anti-mitochondrial, D. Anti-endomysial
C: Anti-mitochondrial
Answer: C: Anti-mitochondrial 
Explanation: Ans. C: Anti-mitochondrial Primary biliary cirrhosis is strongly associated with the presence of anti-mitochondrial antibodies (AMA), which are diagnostic PBC: Associated with CREST syndrome, sicca syndrome, auto-immune thyroiditis, type I DM and IgA deficiency IgG AMA is detected in more than 90% of patients with PBC 90% of women are between 35 - 60 years Earliest symptom is pruritis Eventually hepatocellular failure and poal hypeension develops Lab findings: - Increased serum alkaline phosphatase - Increased serum 5-nucleotidase activity - Increased gamma-glutamyl transpeptidase - Serum bilirubin is usually normal - Aminotransferase levels minimally increased - Treatment: Ursodiol