This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Maternal serum Alpha Feto Protein (MSAFP) raised in all the following conditions except - 
Select and explain. 
A. Spina bifida, B. Multiple pregnancy, C. Omphalocele, D. Down's syndrome
D: Down's syndrome
Answer: D: Down's syndrome 
Explanation: AFP UE3 hCG Associated conditions low low high Down Syndromelow low low trisomy 18 (Edward's syndrome)high n/a n/a neural tube defects (like spina bifida that may have associated increased levels of acetylcholinesterase in the amnionic fluid), omphalocele, gastroschisis, multiple gestation (like twins or triplets), or an underestimation of gestational age.