This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Which of the following causes haemolytic anemia - 
Select and explain. 
A. Hereditary spherocytosis, B. Infection, C. Iron deficiency, D. Sic kle cell anemia
A: Hereditary spherocytosis
Answer: A: Hereditary spherocytosis 
Explanation: In heriditary spherocytosis , as the age of RBC increases they undergo loss of membrane fragments and acheive spherical shape (spherocyte) . spherocytes are rigid inflexible and less deformable hence they get trapped in spleen to premature destruction resulting in hemolytic anemia. Referance:Exam preparatory manual for UGs -Pathology By Ramdas Nayak Page no:264 Ref Robbins 9/e pg 412