This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Gynaecology & Obstetrics
An obese woman with type 2 diabetes and hypeension is diagnosed with endometriod type of endometrial carcinoma. Most probable gene defect expected in this condition is: 
Select and explain. 
A. PTEN, B. p53, C. MSH2, D. BRCA2
A: PTEN
Answer: A: PTEN 
Explanation: Types of Endometrial cancer: Type 1(Endometroid type) Type 2(Serous,clear ,type) Associated with PTEN gene mutations Good prognosis Estrogen dependent Pre - invasive lesions Develops in obese women Associated with P-53 gene mutations Poor prognosis Not estrogen dependent Develops in thin women