This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
True fact regarding Crohn's disease 
Select and explain. 
A. Entero enteric fistula is an indication for urgent surgery, B. Medical management includes antibiotics, immunosuppressive agents and biologic agents, C. No increased risk for colonic cancer, D. No effect on feility
B: Medical management includes antibiotics, immunosuppressive agents and biologic agents
Answer: B: Medical management includes antibiotics, immunosuppressive agents and biologic agents 
Explanation: Crohn's diseaseHLA - DR1 / DQw5 and NOD genes, CD 4+ T cells response Affects ileum but rectum sparedFull thickness - transmural involvement Skip lesions ++Non caseating granuloma ++Stricture ++Fistula ++Anal fissure ++Perianal abscess ++Discontinuous segmental asymmetrical colitis Normal vascular patternDiagnosis of Crohn's diseaseTreatment of Crohn's diseaseAssociated with Saccharomyces cerevisiae antibody Barium meal study - Cobblestone appearance; Rose thorn appearance; String sign of Kantor 5-ASAGlucocoicoidsAzathioprine and 6 Mercaptopurine (or Methotrexate)TNF alpha Therapy (Infliximab; Adalimumab; Ceolizumab)Cyclosporine or Tacrolimus or Natalizumab(Refer: Sabiston's Textbook of Surgery, 19th edition, pg no: 1244-1254)