This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The pathogenesis hypochromic anemia in lead poisoning is due to - 
Select and explain. 
A. Inhibition of enzymes involved in heme biosynthesis, B. Binding of lead to transferrin, inhibiting the transpo of iron, C. Binding of lead to cell membrane of erythroid precursors, D. Binding of lead to ferritin inhibiting their breakdown into hemosiderin
A: Inhibition of enzymes involved in heme biosynthesis
Answer: A: Inhibition of enzymes involved in heme biosynthesis 
Explanation: Ans. is 'a' i.e., Inhibiton of enzymes involved in Heme biosynthesis o Lead interferes with the syntheiss of Heme by inhibiting the enzymes d Aminolevulinic acid dehydrase and Ferrochelatase. These two enzymes are involved in the synthesis of Heme.