This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pediatrics
Celiac disease is children is most commonly associated with: 
Select and explain. 
A. HLA-DQ2, B. HLA-DQ3, C. HLA-DQ8, D. Blood group B
A: HLA-DQ2
Answer: A: HLA-DQ2 
Explanation: Ans. A. HLA-DQ2* Celiac disease is an immune-mediated enteropathy that is triggered by ingestion of gluten in genetically susceptible individuals.* Three factors can activate the disease; Ingestion of gluten-containing products; Dysfunction of intestinal mucosal barrier; and Genetic predisposition (HLA DQ2 / DQ8).* About 95% of patients of celiac disease express HLA-DQ2, and the remaining patients are usually HLA-DQ8 positive.