This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Anticentromere antibodies are most commonly associated with- 
Select and explain. 
A. Diffuse cutaneous systemic sclerosis, B. Mixed connective tissue disease, C. CREST syndrome, D. Polymyositis
C: CREST syndrome
Answer: C: CREST syndrome 
Explanation: CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue disorder. The acronym "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. It is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary aerial hypeension.