This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anaesthesia, Subject name: Anaesthesia
Among the following anaesthetic drug/inducing agents which should be avoided in a patient with a history of epilepsy 
Select and explain. 
A. propofol, B. Thiopentone, C. Ketamine, D. Midazolam
C: Ketamine
Answer: C: Ketamine 
Explanation: The barbiturates (thiopental, methohexital, and pentobarbital) and propofol are well established as agents for the treatment of refractory status epilepticus. Benzodiazepines too are used in status epilepticus. In ketamine, myoclonic activity is associated with increased subcoical electrical activity, which is not apparent on surface EEG. It is contraindicated in epileptic patients.