This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
Which anti-cancer drug affects DNA as well as RNA? 
Select and explain. 
A. 5-FU, B. Methotrexate, C. Actinomycin-D, D. Etoposide
C: Actinomycin-D
Answer: C: Actinomycin-D 
Explanation: Actinomycin-D is one of the anti-tumor antibiotic. It has two mechanisms of action: - It blocks RNA transcription by interfering with template function of DNA. - It causes single strand breaks in the DNA. It is used in the treatment of Wilm's tumor and rhabdomyosarcoma.