This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory system, Subject name: Pathology
Which of the following is true about alpha 1 antitrypsin 
Select and explain. 
A. Inhibits elastase, B. Inhibits trypsinogen activation in pancreas, C. Inhibits trypsin activating protease, D. Inhibits chymotrypsin
A: Inhibits elastase
Answer: A: Inhibits elastase 
Explanation: * alpha 1 antitrypsin deficiency is an Autosomal recessive disorder * It is synthesised in the liver * Deficiecy of alpha 1 antitrypsin can cause panacinar emphysema and can affect the liver. * Normal (wild) genotype of PiMM * alpha 1 antitrypsin deficiency can cause globular cytoplasmic inclusions in hepatocytes * These inclusions are PAS positive and diastase resistant Ref:- Robbins Basic Pathology 10th Edition; Pg num:- 658,659