This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pediatrics
The characteristic facies of the following may resemble that of Downs syndrome: 
Select and explain. 
A. Rhizomelic chondrodysplasia, B. Infantile Refsum disease, C. Zellweger syndrome, D. Neonatal adreno leukodystrophy
C: Zellweger syndrome
Answer: C: Zellweger syndrome 
Explanation: (C) Zellweger syndrome# ZELLWEGER SYNDROME: Children demonstrate facial dysmorphology with a prominent forehead, large anterior fontanellae, epicanthal folds, micrognathia, high arched palate, and deformed ear lobes.> Characteristic Zellweger syndrome facies may resemble that of Downs syndrome.> Other features include profound hypotonia, hepatic dysfunction, hepatomegaly, retinal degeneration, sensorineural hearing loss, renal cysts and calcific stippling of the epiphyses.> Peroxismol biogenesis disorders (PBDs) include Zellweger syndrome, Neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IR), & Rhizomelic chondrodysplasia punctata (RCP).> Zellweger syndrome, NALD, and IRD represent a spectrum of disroders with similar and overlapping clinical features.