This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Which of the following receptor gene has the ability to control TSH secretion? 
Select and explain. 
A. TR alpha 1, B. TR alpha 2, C. TR beta 1, D. TR beta2
D: TR beta2
Answer: D: TR beta2 
Explanation: The THRB gene has two promoters that lead to the production of TR beta 1 and TR bete 2. TR beta 1 is ubiquitous, whereas TR beta 2 has a highly restricted pattern of expression. Mutations in THRB cause the syndrome of resistance to thyroid hormone. TR beta 1 has a specific role in liver metabolism (including the hypocholesterolemic effect of T3). Role of TR beta 2 is in the negative feedback by T3 on hypothalamic TRH and pituitary TSH. TR beta 2 also is impoant in the development of cones in the retina and in inner ear development. Ref: Brent G.A., Koenig R.J. (2011). Chapter 39. Thyroid and Anti-Thyroid Drugs. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.