This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipoproteins, Subject name: Biochemistry
Deficiency of Acid lipase:- 
Select and explain. 
A. Fabry disease, B. Gaucher disease, C. Farber disease, D. Wolman disease
D: Wolman disease
Answer: D: Wolman disease 
Explanation: Deficiency Disease Group Acid maltase Pompe's disease Glycogen storage disease Acid lipase Wolman disease Lysosomal storage disease Wolman disease Not a sphingolipidosis. Cholesterol ester storage disease Lysosomal acid lipase deficiency Triglyceride | C/F Vomiting Watery green diarrhea Hepatosplenomegaly Calcification of adrenals (characteristic feature) Rx- Enzyme replacement therapy Gaucher's disease It is the most common lysosomal storage disorder. It is characterized by the following clinical features: Painless hepatomegaly and splenomegaly Liver cirrhosis Hypersplenism and pancytopenia Bleeding tendencies Bone pain Osteoporosis, pathological fractures Developmental delay, hypeonia, strabismus, supranuclear gaze palsy. Treatment : Enzyme replacement therapy is available in the form of Human recombinant acid b-glucosidase(Imiglucerase) Velaglucerase alfa Taliglucerase alfa Note:Neurological involvement is not seen in type I Gaucher's disease.