This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anatomy
Hirsprung disease is due to 
Select and explain. 
A. Loss of anterior longitudinal cells, B. Loss of ganglionic cell in paraveebral sympathetic chain, C. Failure of migration of neural crest.cell from cranial tocaudal direction, D. Idiosyncratic
C: Failure of migration of neural crest.cell from cranial tocaudal direction
Answer: C: Failure of migration of neural crest.cell from cranial tocaudal direction 
Explanation: C i.e. Failure of migration of neural crest cells from cranial to caudal direction