This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
End–tidal CO2 is increased to maximum level in – 
Select and explain. 
A. Pul. embolism, B. Malignant hyperthermia, C. Extubation, D. Blockage of secretion
B: Malignant hyperthermia
Answer: B: Malignant hyperthermia 
Explanation: The unanticipated doubling or tripling of end tidal CO2 is the earliest & most sensitive indicator of malignant hyperthermia. The earliest signs seen during anesthesia are masseter muscle rigidity (MMR), tachycardia, & hypercarbia.