This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Systemic Bacteriology (Gram Positive Bacilli, Gram Negative Bacilli), Subject name: Microbiology
Mark the false statement regarding L forms of bacteria 
Select and explain. 
A. Also known as cell wall deficient bacteria, B. It was first isolated in Streptobacillus, C. Develops from only gram negative bacteria, D. Can lead to bacterial persistence during antibiotic treatment
C: Develops from only gram negative bacteria
Answer: C: Develops from only gram negative bacteria 
Explanation: L-forms bacteria/asL-phase bacteria Also known as L-phase variants or cell wall-deficient(CWD)bacteria Grow as spheroplasts or protoplasts. 1st isolated working on a culture of "Streptobacillus moniliformis." L forms may not initiate a disease however they can lead to bacterial persistence during antibiotic treatment = Recurrence of infection. It was used in Lister institute in London 2 types Unstable L-forms - Spheroplasts that are capable of dividing, but can reve to the original morphology Stable L-forms - L-forms that are unable to reve to the original bacteria. Although L-forms can develop from Gram positive as well as from Gram negative bacteria but during Gram stain, the L-forms always colour Gram-negative, due to the lack of a cell wall.