This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Dose of drug require no or minor adjustment in renal failure, except - 
Select and explain. 
A. Doxycycline, B. Vancomycin, C. Chloramphenicol, D. Clindamycin
B: Vancomycin
Answer: B: Vancomycin 
Explanation: Ans. is 'b' i.e., Vancomycin o Vancomycin causes renal toxicity which is dose related therefore significant dose reduction is needed in renal failure. o Rest of the drugs asked in the question are metabolised mainly in liver therefore no adjustment needed in renal failure.