This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Digoxin can accumulate to toxic levels in patients with ? 
Select and explain. 
A. Renal insufficiency, B. Chronic hepatitis, C. Advanced cirrhosis, D. Chronic pancreatitis
A: Renal insufficiency
Answer: A: Renal insufficiency 
Explanation: None