This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
LCAT deficiency increases the following 
Select and explain. 
A. Chylomicrons, B. IDL, C. VLDL, D. HDL
D: HDL
Answer: D: HDL 
Explanation: * HDL is synthesized and secreted from both liver and intestine * Lecithin:cholesterol acyltransferase (LCAT) activity is associated with HDL containing apo A-I. * As cholesterol in HDL becomes esterified, it creates a concentration gradient and draws in cholesterol from tissues and from other lipoproteins thus enabling HDL to function in reverse cholesterol transpo * Absence of LCAT leads to block in reverse cholesterol transpo. HDL remains as nascent disks incapable of taking up and esterifying cholesterol. Ref:- Harper 30/e; pg num:- 249, 272