This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Fuel in Fed, Fasting and Starvation, Subject name: Biochemistry
During starvation, which of the following shows the most marked increase in plasma concentration: 
Select and explain. 
A. Glycogen, B. Glucose, C. Ketone bodies, D. Free fatty acids
C: Ketone bodies
Answer: C: Ketone bodies 
Explanation: During starvation=Ketone Bodies are increased in blood It is the fuel for vital organs:-hea,brain and skeletal muscles. Liver constantly synthesize minimal amounts of Ketone Bodies normally but the amounts are significantly raised during Fasting and Starvation as these organs extract ATPs (energy) from them. WITH REGARDS TO OTHER OPTIONS: (Option 1 and 2) i.e glycogen and glucose respectively are decreased during starvation. (Option 4) Free fatty acids are increased in both fasting and starvation.