This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is associated with > 20% risk of chromosomal anomalies: 
Select and explain. 
A. Omphalocele, B. Cleft palate, C. Cleft lip, D. Spina bifida
A: Omphalocele
Answer: A: Omphalocele 
Explanation: Omphalocele