This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Drug causing decrease in late sodium current ? 
Select and explain. 
A. Nicorandil, B. Ranolazine, C. Trimetazidine, D. Molsidomine
B: Ranolazine
Answer: B: Ranolazine 
Explanation: Ans. is 'b' i.e., Ranolazine Ranolazine Ranolazine is an effective newer anti-anginal drug but unlike CCBs and beta-blockers it does not significantly alter the hea rate or blood pressure. Ranolazine alters the trans-cellular late sodium current and affects the sodium-dependent calcium channels during myocardial ischemia thus prevents calcium overload, resulting in reduced oxygen demand, and prevent angina. Ranolazine is useful as add-on therapy in chronic stable angina which is refractory to more standard anti-anginal medication. However, it is not found to be useful in acute coronary syndrome.