This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
ACE inhibitors should not be used along with ? 
Select and explain. 
A. Amiloride, B. CCB, C. Spironolactone, D. Thiazides
C: Spironolactone
Answer: C: Spironolactone 
Explanation: Ans. is 'c' i.e., Spironolactone ACE inhibitor and diuretics ACE inhibitors cause hyperkalemia, therefore they can be combined with furosemide or thiazide diuretics which cause hypokalemia and nullify the hyperkalemic effect of ACE inhibitors. On the other hand potassium sparing diuretics (spironolactone, eplerenone, amiloride, triamterene) are contraindicated as they cause hyperkalemia and aggrevate the hyperkalemia caused by ACE inhibitors.