This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is the most important mediator implicated in development of fever: 
Select and explain. 
A. PGF2, B. PGE2, C. PGD2, D. FGA2
B: PGE2
Answer: B: PGE2 
Explanation: PGF2α is a vasoconstrictor whereas PGD2 and PGE2 are vasodilators. 
PGE2 is the most important chemical for development of fever.