This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Ketone bodies are used by all except ? 
Select and explain. 
A. Brain, B. RBCs, C. Skeletal muscles, D. Hepatocytes
D: Hepatocytes
Answer: D: Hepatocytes 
Explanation: Ans. is 'd' i.e., Hepatocytes Ketone bodies are synthesized by liver and are utilized by extrahepatic tissues like hea, muscles, renal coex and brain (in starvation). Liver cannot utilize ketone bodies because it lacks enzyme succinyl-CoA-acetoacetate CoA transferase, which is required for the activation of ketone bodies. The first reaction in use of ketone bodies is activation of acetoacetate. CoA-transferase Succinyl CoA + acetoacetate ___________________ Acetoacetyl CoA + succinate