This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Musculoskeletal  disorders, Subject name: Pediatrics
Which of the following is false regarding brittle bone disease? 
Select and explain. 
A. It is caused by defects in type 2 collagen, B. Predominantly autosomal-dominant inheritance is seen, C. Blue sclerae and deafness may be associated, D. Bisphosphonates are useful in the treatment
A: It is caused by defects in type 2 collagen
Answer: A: It is caused by defects in type 2 collagen 
Explanation: Brittle bone disease is another name for osteogenesis imperfecta (OI). It is due to defects in type 1 collagen, not type 2 collagen. There are 12 types of OI, with type 1 being the most common. Triad of fragile bones, blue sclera and deafness is known as van der Hoeve syndrome. Treatment includes bisphosphonate therapy and ohopedic rehabilitation. Ref: Nelson textbook of pediatrics 21st edition pgno: 3737