This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Microbiology
Cell mediated immunity is markedly depressed in 
Select and explain. 
A. Tuberculoid leprosy, B. Lepromatous leprosy, C. Polyneuritic form of leprosy, D. Indeterminate leprosy
B: Lepromatous leprosy
Answer: B: Lepromatous leprosy 
Explanation: (B) Lepromatous leprosy# In untreated LL patients, lymphocytes regularly fail to recognize either M. leprae or its protein constituents, and lepromin skin tests are negative.> This loss of protective cellular immunity appears to be antigen-specific, as patients are not unusually susceptible to opportunistic infections, cancer, or AIDS and maintain delayed-type hypersensitivity to Candida, Trichophyton, mumps, tetanus toxoid, and even purified protein derivative of tuberculin.> Lepromatous leprosy, has the greatest number of bacilli and is characterized by early, widespread, ill-defined, erythematous or hypopigmented papules and plaques. Later findings include facial infiltration (leonine facies), ocular effects, neurologic involvement, and hypogonadism.