This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Zero order kinetics is independent of: 
Select and explain. 
A. Plasma concentration, B. Clearance, C. Volume of distribution, D. Half life
A: Plasma concentration
Answer: A: Plasma concentration 
Explanation: Plasma concentration REF: Katzung's pharmacology 10th edition page 38 See APPENDIX-33 for 'Chemical kinetics of drugs" Drugs may follow zero order, first order or second order kinetics. It depends on following formula: Rate of elimination a degr`l" Thus for zero order kinetics, rate of elimination is independent of plasma concentration.