This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Malaria Drugs, Subject name: Pharmacology
Which of the following antimalarial agents is most commonly associated with acute hemolytic reaction in patients with glucose-6- phosphate dehydrogenase deficiency? 
Select and explain. 
A. Chloroquine, B. Clindamycin, C. Mefloquine, D. Primaquine
D: Primaquine
Answer: D: Primaquine 
Explanation: -Primaquine can cause hemolytic anemia in patients with even mild deficiency of G-6-PDdue to its oxidative propeies. - Symtoms include passage of dark coloured urine which indicate hemolysis and the drug must be stoppped. - Quinine, chloroquine and hydroxychloroquine can also cause hemolysis in G-6-PD deficient patients but the frequency is less than that of primaquine.