This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bony dysplasia and soft tissue affection, Subject name: Orthopaedics
Brittle bone disease is - 
Select and explain. 
A. Osteogenesis imperfecta, B. Osteopetrosis, C. Pagets disease, D. Osteoporosis
A: Osteogenesis imperfecta
Answer: A: Osteogenesis imperfecta 
Explanation: Osteogenesis imperfecta is also known as Fragilitas ossium or Vrolick&;s disease which is characterised by tendency for frequent fractures because of weak and brittle bones. It results from defective collagen synthesis and thus affects other collagen containing soft tissues like skin, sclera, teeth, ligaments etc. as well. Disease commonly inherited as autosomal dominant disorder but a severe variant known to occur where the inheritance is autosomal recessive. REF:Reference- Essential ohopaedics- Maheshwari-5th edn-pg no316