This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Notch effect in embryogenesis is an example of which type of signalling? 
Select and explain. 
A. Autocrine, B. Paracrine, C. Endocrine, D. None of the above
B: Paracrine
Answer: B: Paracrine 
Explanation: One cell type produces the ligand, which then acts on adjacent target cells that express the appropriate receptor. The responding cells are in close proximity to the ligand-producing cell and are generally of a different type. Paracrine stimulation is common in connective tissue repair of healing wounds, in which a factor produced by one cell type (e.g., a macrophage) has a growth effect on adjacent cells (e.g., a fibroblast). It is also necessary for hepatocyte replication during liver regeneration and for Notch effects in embryonic development, wound healing, and renewing tissues. Ref: Robbins 8th edition, Chapter 3