This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Li-Fraumeni syndrome has the risk of development of: 
Select and explain. 
A. Squamous cell carcinoma, B. Basal cell carcinoma, C. Osteosarcoma, D. Both 1 & 3
D: Both 1 & 3
Answer: D: Both 1 & 3 
Explanation: Li-Fraumeni syndrome (germline TP53 mutation) is a predisposing factor for osteosarcoma development.
Reference: Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 227