This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2019, Subject name: Biochemistry
Defect in Menke disease: 
Select and explain. 
A. Lysyl hydroxylase, B. Lysyl oxidase, C. Prolyl hydroxylase, D. Prolyl oxidase
B: Lysyl oxidase
Answer: B: Lysyl oxidase 
Explanation: MENKE DISEASE / kinky OR STEEL HAIR SYNDROME- deficiency of copper results in defective crosslinking of collagen and elastin by the copper-dependent enzyme lysyl oxidase. Defect in dietary absorption of copper Die with in 5 years of age Kinky hair and growth retardation. menke disease is X linked disease due to mutation in ATP 7 A gene. This gene is present on Xp 12-13.