This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc. (R.B.C), Subject name: Pathology
Leptocyte in blood smears seen in? 
Select and explain. 
A. Sickle cell anemia, B. Thalassemia, C. Post splenectomy, D. Uremia
B: Thalassemia
Answer: B: Thalassemia 
Explanation: Ans. (b) Thalassemia(Ref: Robbins 9th/pg 649-652)Leptocytes are flattened red cells in which the volume-to- surface area ratio is decreased. Seen in iron deficiency anemia and thalassemia in which the red cells with a low mean cell hemoglobin (MCH) and mean cell volume (MCV) are unusually resistant to osmotic lysis.