This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Which of the following is caused by defective tyrosine metabolism? 
Select and explain. 
A. Richner-Hanha syndrome, B. Neonatal tyrosinemia, C. Alkaptonuria, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: Metabolic diseases of tyrosine catabolism include tyrosinosis, Richner-Hanha syndrome, neonatal tyrosinemia, and alkaptonuria. Ref: Harper 28th edition, chapter 29.