This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
'Hand and Foot' syndrome can be caused by: 
Select and explain. 
A. Cisplatin, B. Vincristine, C. Capecitabine, D. Mitomycin-C
C: Capecitabine
Answer: C: Capecitabine 
Explanation: CAPECITABINE is a PYRAMIDINE ANTAGONIST. It is an orally active prodrug of 5-FU.A combined regimen of capecitabine and oxaliplatin is frequently used in metastatic colorectal cancer. HAND-FOOT syndrome and diarrhoea are the prominent adverse effects,but bone marrow depression and mucositis are less marked. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D.TRIPATHI SEVENTH EDITION PAGE NO:864