This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorder of Metabolism & Connective Tissue, Subject name: Medicine
A 2-year-old male has developmental delay kinke hair and weak muscle tone. What is the diagnosis? 
Select and explain. 
A. Wilson's disease, B. Menkes disease, C. Zinc deficiency, D. Cerebral palsy
B: Menkes disease
Answer: B: Menkes disease 
Explanation: ANS. BMenkes disease, also known as Menkes syndrome, is an X-linked recessive disorder that affects copper levels in the body, leading to copper deficiency (ATB 7A gene on chromosome 13).Signs and symptoms of this disorder include:1. Weak muscle tone (hypotonia)2. Sagging facial features3. Seizures4. Intellectual disability and developmental delay5. Brittle hair6. Metaphyseal widening.Menkes diseaseImage of zinc deficiency (acrodermatitis enteropathica)