This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Following is true about inverse agonist ? 
Select and explain. 
A. Affinity + Intrinsic activity +, B. Affinity + Intrinsic activity 0, C. Affinity - Intrinsic activity ?, D. Affinity + Intrinsic activity -
D: Affinity + Intrinsic activity -
Answer: D: Affinity + Intrinsic activity - 
Explanation: Ans. is 'd' i.e., Affinity + Intrinsic activity - Receptors are specific binding site with functional correlate. In relation to action through receptors, two terms are impoant.