This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
The term MHC restriction refers to which of the following statements? 
Select and explain. 
A. Inheritance of MHC molecules, B. Need for antigen to be recognized in association with MHC molecules, C. Need for MHC genes to control complement activity, D. Need for MHC molecules in order to reject grafts
B: Need for antigen to be recognized in association with MHC molecules
Answer: B: Need for antigen to be recognized in association with MHC molecules 
Explanation: MHC class I- or class II-restriction means that T cells recognize antigen peptide fragments only when they are presented in the antigen-recognition site of a class I (for CD8+ T cells) or class II MHC molecule(for CD4+ T cells), respectively.