This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mycology, Subject name: Microbiology
What is the most probable poal of entry of Aspergillus? 
Select and explain. 
A. Puncture wound, B. Blood, C. Lungs, D. Gastrointestinal tract
C: Lungs
Answer: C: Lungs 
Explanation: Aspergillus species are widely distributed on decaying plants, producing chains of conidia. Aspergillus species unlike Candida species do not form the pa of normal flora of humans. They are ubiquitous in the environment; hence transmission of infection is mostly exogenous. Aspergillus transmission occurs by inhalation of airborne conidia. Risk Factors for invasive aspergillosis are: Glucocoicoid use (the most impoant risk factor) Profound neutropenia or Neutrophil dysfunction Underlying pneumonia or COPD, tuberculosis or sarcoidosis Antitumor necrosis factor therapy.