This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Osteoporosis, Sex Hormones and OCPs, Subject name: Pharmacology
Long term adverse effect of tamoxifen is 
Select and explain. 
A. Weight gain, B. Osteoporosis, C. Venous thrombosis, D. Breast cancer
C: Venous thrombosis
Answer: C: Venous thrombosis 
Explanation: TAMOXIFEN - It is SERM - Actions Bone - | formation of bone; decrease risk of osteoporosis Blood - | HDL Breast -Decrease risk of breast cancer Liver - | clotting factor leading to thromboembolism Endometrium - | risk of endometrial cancer