This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Gluten-sensitive enteropathy is most strongly associated with – 
Select and explain. 
A. HLA–DQ2, B. BLA–DR4, C. HLA–DQ3, D. Blood group B
A: HLA–DQ2
Answer: A: HLA–DQ2 
Explanation: Almost all individuals with celiac disease share the major histocompatibility complex II HLA-DQ2 or HLA-DQ8.
Gliadin is deamidated by the enzyme transglutaminase and deamidated gliadin peptides bind to DQ2 and DQ8.
Recognition of these peptides by CD4+ T cells leads to secretion of IFN-γ, which damages the intestinal wall.