This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
Drawback of aesunate is: 
Select and explain. 
A. Poor bioavailability, B. Rapid recrudescence of malaria, C. Hypoglycemia, D. Hemolysis
B: Rapid recrudescence of malaria
Answer: B: Rapid recrudescence of malaria 
Explanation: Because aemisinins are sho acting drugs, monotherapy needs to be extended beyond the disappearance of the parasites to prevent recrudescence. After 5 days treatment recrudescence rate is -10%, while with a 3 day course it is -50%. Recrudescence can be totally prevented by combining 3 day aesunate/aemether with a long acting drug ESSENTIALS OF MEDICAL PHARMACOLOGY page no. 830