This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
One of the following causes nephrotoxicity and hypeension which is similar to cyclosporine: 
Select and explain. 
A. Azathioprine, B. Cyclophosphamide, C. Mycophenolate mofetil, D. Tacrolimus
D: Tacrolimus
Answer: D: Tacrolimus 
Explanation: Tacrolimus (FK 506) is an immunosuppressant macrolide antibiotic produced by Streptomyces tsukubaensis. Tacrolimus binds to the immunophilin FK-binding protein (FKBP). This complexe inhibit calcineurin, which is necessary for the activation of the T-cell-specific transcription factor NF-AT. Its toxic effects are similar to those of cyclosporine and include nephrotoxicity, neurotoxicity, hyperglycemia, hypeension, hyperkalemia, and gastrointestinal complaints. Ref: Lake D.F., Briggs A.D., Akporiaye E.T. (2012). Chapter 55. Immunopharmacology. In B.G. Katzung, S.B. Masters, A.J. Trevor (Eds), Basic & Clinical Pharmacology, 12e.