This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Hormone that stimulates gluconeogenesis is: 
Select and explain. 
A. Glucagon, B. Epinephrine, C. None of the above, D. Both of the above
D: Both of the above
Answer: D: Both of the above 
Explanation: Ans:D.)Both of the Above. Glucagon and epinephrine, hormones that are responsive to a decrease in blood glucose, inhibit glycolysis and stimulate gluconeogenesis in the liver by increasing the concentration of cAMP. This in turn activates cAMP-dependent protein kinase, leading to the phosphorylation and inactivation of pyruvate kinase. They also affect the concentration of fructose 2,6-bisphosphate and therefore glycolysis and gluconeogenesis Ref: Harper 28thedition, chapter 20.