This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
In type 2 DM, increased fasting plasma glucose is predominantly due to 
Select and explain. 
A. Increased hepatic glucose output, B. Decreased peripheral utilization of glucose, C. Decreased insulin secretion, D. Decreased transpo of glucose to tissue
A: Increased hepatic glucose output
Answer: A: Increased hepatic glucose output 
Explanation: Insulin resistance impairs glucose utilization by insulin-sensitive tissues and increases hepatic glucose output; both effects contribute to the hyperglycemia. Increased hepatic glucose output predominantly accounts for increased FPG levels, whereas decreased peripheral glucose usage results in postprandial hyperglycemia. Glucose metabolism in insulin-independent tissues is not altered in type 2 DM.Ref: Harrison 19e pg: 2405