This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
E cadherin gene deficiency is seen in- 
Select and explain. 
A. Gastric ca, B. Intestinal ca, C. Thyroid ca, D. Pancreatic ca
A: Gastric ca
Answer: A: Gastric ca 
Explanation: Harshmohan textbook of pathology 7th edition. Familial gastric cancer is strongly associated with germline loss of function mutation in the tumor suppressor gene CDH1, which encoded the cell adhesion protein E- catherin. Loss of function mutation in CDH1 are also present in about 50% of sporadic diffuse gastric tumor, while E- Catherin expression is drastically decreased in the rest. often by hyper methylation and silencing of the CDH1 promoter. This the loss of E Catherin is the key step in the development of diffuse gastric cancer..