This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
What is the FIRST manifestation of most cell injuries? 
Select and explain. 
A. Cellular swelling, B. Necrosis, C. Apoptosis, D. Chromatin condensation
A: Cellular swelling
Answer: A: Cellular swelling 
Explanation: Cellular swelling is the first manifestation of almost all forms of injury to cells. When it affects many cells, it causes some pallor, increased turgor and increase in weight of the organ. On microscopic examination, small clear vacuoles may be seen within the cytoplasm; these represent distended and pinched-off segments of the ER. This pattern of nonlethal injury is sometimes called hydropic change or vacuolar degeneration. Swelling of cells is reversible. Ref: Robbins 8th edition, Chapter 1.