This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Non specific esterase in present in- 
Select and explain. 
A. Megakaryocytic leukaemia, B. Lymphocytic leukaemia, C. Erythroleukaemia, D. AML
D: AML
Answer: D: AML 
Explanation: Ans. is 'd i.e., AML Acute Myelogenous leukemia (AML) o AML is a cancer of myeloid line of WBCs, characterized by the rapid proliferation of abnormal cells which accumulate in the bone marrow and interfere with the production of normal blood cells. o AML is the most common acute leukemia affecting adults. o The diagnosis of AML is based on finding that myeloid blasts make up more than 20% of the cells in the marrow. o Myeloblasts are mveloperoxidase (peroxidase) positive. o Auer rods (Represent abnormal azurophilic granule) are also present in myeloblasts and their presence is taken to be definite evedence of myeloid defferentiation. o In some AMLs, blast cells exhibit differentiation of other myeloid stem cell line (other than myeloblast), e.g., i) Monoblast Lack auer rods, peroxidase negative, but nonspecific esterase positive. Megakaryocytic differentiation Erythroblast