This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Which vitamin deficiency is responsible for neonatal seizure – 
Select and explain. 
A. Pyridoxine, B. Vitamin C, C. Thiamine, D. Cobalamin
A: Pyridoxine
Answer: A: Pyridoxine 
Explanation: Pyridoxine (Vitamin B6) dependency with seizures is an autosomal recessive condition.
It is due to GABA deficiency in the brain, which is presumbly caused by decreased activity of GAD (glutamic acid decarboxylase).
Administration of large doses of pyridoxin usually results in a dramatic improvement of both seizures and EEG abnormalities, as pyridoxin acts as a cofactor for GAD and improves its activity.