This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All the following drugs are given by sublingual route EXCEPT: 
Select and explain. 
A. Isosorbide dinitrate, B. Buprenorphine, C. Glyceryl trinitrare, D. Isosorbide-5-mononitrate
D: Isosorbide-5-mononitrate
Answer: D: Isosorbide-5-mononitrate 
Explanation: Isosorbide-5-mononitrate