This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is not true regarding apoptosis? 
Select and explain. 
A. Step ladder pattern on agarose gel electrophoresis, B. Apoptosis is energy independent process., C. Annexin V is a marker of apoptosis, D. Caspases are endonucleases
D: Caspases are endonucleases
Answer: D: Caspases are endonucleases 
Explanation: Caspases are cysteinyl aspartate proteinases. They are cysteine proteases that cleave their substrates following an aspartate residue. They will activate endonucleases leading to chromatin clumping.