This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypolipidemic, Subject name: Pharmacology
Statins act on which enzyme - 
Select and explain. 
A. Acyl CoAsynthetase, B. Acyl Co A reductase, C. HMG CoA Synthetase, D. HMG CoA reductase
D: HMG CoA reductase
Answer: D: HMG CoA reductase 
Explanation: Ans. is 'd' i.e., HMG CoA reductase Hypolipidemic drugsHMG-CoA reductase inhibitors (statins) - Lovastatin. Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin.Bile acid sequestrants (Resins) - cholestyramine, colestipol.Activate lipoprotein lipase (fibric acid derivatives) - clofibrate, gemfibrozil, bezafibrate, fenofibrate.4.Inhibit lipoly sis and triglyceride synthesis - Nicotinic acid.5,Other - Probueol, Gugulipid, Ezetimibe, Avasimibe, Torcetrapib.o Ezetimibe inhibits intestinal cholesterole absorption.o Avasimibe inhibits enzyme acyl Coenzyme A ; cholesterol acyl transferase-1 (ACAT-1) which causes esterification of cholesterol.o Torcetrapib inhibits cholesterol ester triglyceride transport protein -| HDL cholesterol.