This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
Chediak - Higashi syndrome, true is: 
Select and explain. 
A. Defect in phagocytosis, B. Neutropenia, C. Agammaglobulinemia, D. IgA deficiency
A: Defect in phagocytosis
Answer: A: Defect in phagocytosis 
Explanation: Ans. is 'a' i.e., Defect in phagocytosis (Ref: CP Baveja, 5th/e, p. 150)* Chediak - Higashi syndrome is a rare autosomal recessive disorder that arises from a mutation of LYST gene codes for lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis. Failure of phagolysosome fusion, defective chemotaxis. The decrease in phagocytosis results in recurrent pyogenic infections, partial albinism and peripheral neuropathy.