This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pathology
ADAMTS 13 is associated with which of the following disorders? 
Select and explain. 
A. TTP, B. Churg Strauss syndrome, C. Wegener's granulomatosis, D. Membranous nephropathy
A: TTP
Answer: A: TTP 
Explanation: ADAMTS 13:- -Metalloprotease enzyme which inhibits VWF clumps. -cleaves VWF multimers into smaller monomers for eventual degradation Thrombotic Thrombocytopenic purpura (TTP)- Causes- Deficiency of ADAMTS 13 Ab formation against ADAMTS 13 - |ADAMTS 13 activity - VWF clumping - Platelet-Thrombi present C/F - Thrombocytopenia Microangiopathic Hemolytic anaemia Fever Renal failure CNS features Rx- Plasmapheresis