This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Types of Genetic Disorders, Subject name: Pediatrics
Single gene defect causing multiple unrelated problems is called? 
Select and explain. 
A. Pleiotropism, B. Pseudodominance, C. Penetrance, D. Anticipation
A: Pleiotropism
Answer: A: Pleiotropism 
Explanation: Pleotropism refers to single gene defect causing multiple traits. Penetrance- extent to which a paicular gene or set of genes is expressed in the phenotypes of individuals carrying it Pseudodominance- sudden appearance of a recessive phenotype in a pedigree, due to deletion of a masking dominant gene Anticipation- disease manifestation worsen from 1 generation to next