This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Most commonly associated mutation in prostratic carcinoma is? 
Select and explain. 
A. p16\/INK4a, B. PTEN, C. GPST 1, D. APC
C: GPST 1
Answer: C: GPST 1 
Explanation: Harshmohan textbook of pathology 7th edition. prostatic carcinoma- at genetic level following epigenetic phenomenon and acquired somatic mutation have been repoed in development of prostatic carcinoma. 1. Epigenetic phenomenon- hyper methylation of GSTP 1 gene promoter causing loss of function of the gene that detoxifyes carcinogens. .