This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
Which is true in diabetes mellitus type II - 
Select and explain. 
A. Insulinitis of B cells, B. Hyalinisation of B cells, C. Atrophy of B cells, D. decrease of B cells
D: decrease of B cells
Answer: D: decrease of B cells 
Explanation: In the early stages of type 2 diabetes, reduction in the total mass of pancreatic islet tissue is modest. At the time of diagnosis, around 50% of b-cell function has been lost and this declines progressively . Some pathological changes are typical of type 2 diabetes, the most consistent of which is deposition of amyloid in the islets. In addition, elevated plasma glucose and FFAs exe toxic effects on pancreatic b cells to impair insulin secretion. However, while b-cell numbers are reduced, b-cell mass is unchanged and glucagon secretion is increased, which may contribute to hyperglycaemia. REf - davidsons 23e p753