This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
Gynecomastia is not associated with which of the following? 
Select and explain. 
A. Use of Anabolic steroids, B. A person with (45, XO) karyotype, C. Alcoholic cirrhosis, D. Antiretroviral therapy
B: A person with (45, XO) karyotype
Answer: B: A person with (45, XO) karyotype 
Explanation: Gynecomastia Gynecomastia is the enlargement of the male breast Benign lesion Occurs as a result of an imbalance between estrogens, which stimulate breast tissue, and androgens, which counteract these effects May appear during pubey, in the very aged, or at any time during adult life when there is cause for hyperestrinism, the most impoant of these is cirrhosis of the liver Drugs such as alcohol, marijuana, heroin, antiretroviral therapy, and anabolic steroids have been associated with gynecomastia. Rarely, gynecomastia occurs as pa of Klinefelter syndrome (47, XXY karyotype) or in association with functioning testicular neoplasms, such as Leydig cell or Seoli cell tumors. Breast development is defective in Turner syndrome (45, XO karyotype).