This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
The following is a generalized diagram of a typical eukaryotic gene , What is the most likely effect of a 2bp insertion in the middle of the intron? 
Select and explain. 
A. Normal transcription, altered translation, B. Defective termination of transcription, normal translation, C. Normal transcription, defective mRNA splicing, D. Normal transcription, normal translation
D: Normal transcription, normal translation
Answer: D: Normal transcription, normal translation 
Explanation: Introns are non-coding region of gene which are processed out of primary transcript. Hence, any change in intron will not effect transcription or translation.