This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
Most B/L multifocal retinoblastoma require – 
Select and explain. 
A. Chemotherapy, B. Radiotherapy, C. Enucleation, D. Multimodality therapy
D: Multimodality therapy
Answer: D: Multimodality therapy 
Explanation: Chemotherapy is now the first line of treatment in most cases of bilateral retinoblastoma. In some children, chemotherapy alone induces complete regression of all treated tumors. More frequently, the chemotherapy shrinks the intraocular tumors (chemoreduction) so that the residual lesions can be eradicated by local treatments like laser therapy, cryotherapy or brachytherapy, i.e., multimodality therapy.