This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Vigorous treatment of nephritis in SLE is indicated in: 
Select and explain. 
A. Class I & II, B. Class III & IV, C. Class IV & V, D. Class V & VI
B: Class III & IV
Answer: B: Class III & IV 
Explanation: Renal Biopsy in SLE: The pattern and severity of injury are impoant in diagnosis and selecting the best therapy. Aggressive immunosuppressive treatment is indicated in : Class III and IV disease Class V accompanied by III or IV disease Treatment for lupus nephritis is not recommended in class I or II disease or with extensive irreversible changes. Classification of Lupus Nephritis (International Society of Nephrology and Renal Pathology Society) Class I: Minimal Mesangial Lupus Nephritis Class II: Mesangial Proliferative Lupus Nephritis Class III: Focal Lupus Nephritis Class IV: Diffuse Lupus Nephritis Class V: Membranous Lupus Nephritis Class VI: Advanced Sclerotic Lupus Nephritis Ref:Harrison,E-18,P-2733