This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following disease modifying anti–rheumatic drugs (DMARDs) is the drug of first choice ? 
Select and explain. 
A. Methotrexate, B. Gold compounds, C. D-penicillamine, D. Anakinra
A: Methotrexate
Answer: A: Methotrexate 
Explanation: None