This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
Which of following is the most common cause of hypergonadotrophichypogonadism in nuk>>- 
Select and explain. 
A. Viral orchitis, B. Klinefelter's syndrome, C. Kallman's syndrome, D. Noonan syndrome
B: Klinefelter's syndrome
Answer: B: Klinefelter's syndrome 
Explanation: Ans is option 2.. Klinefelter&;s syndrome Hypogonadism occurs if the hypothalamic pituitary axis is interrupted at any level. Hypergonadotrophic Hypogonadism occurs due to low testosterone and increased LH and FSH Most common cause of Hypergonadotrophic Hypogonadism in males is Klinefelter&;s syndrome In females turner syndrome Ref Harrison 17 /e p 2316 2317