This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urea cycle, Subject name: Biochemistry
Which one of the following is a symptom of ammonia intoxication? 
Select and explain. 
A. Slurring of speech, B. Abdominal pain, C. Diarrhea, D. Constipation
A: Slurring of speech
Answer: A: Slurring of speech 
Explanation: One of earlier symptoms of ammonia intoxication is haziness of vision and slurring of speech Other clinical features of urea cycle defects:- Increased blood glutamine Decreased BUN (Blood Urea Nitrogen) Cerebral oedema Vomiting Lethargy hyperventilation Note:-Severe ammonia toxicity can lead to coma and eventually death.