This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Orthopaedics
Management plan for osteogenic sarcoma of the lower end of femur must include - 
Select and explain. 
A. Radiotherapy, amputation, chemotherapy, B. Surgery alone, C. Chemotherapy + Limb Salvage Surgery + Chemotherapy, D. Chemotherapy + Radiotherapy
C: Chemotherapy + Limb Salvage Surgery + Chemotherapy
Answer: C: Chemotherapy + Limb Salvage Surgery + Chemotherapy 
Explanation: The usual protocol is : -


First give neoadjuvant chemotherapy (Pre-operative chemotherapy).
Neo-adjuvant chemotherapy is followed by surgery : - This may be limb salvage surgery (most of the time) or amputation depending on the situation.
Surgery is followed by postoperative chemotherapy.