This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Liver, Subject name: Surgery
Which of the following statement is true regarding pyogenic liver abscess? 
Select and explain. 
A. Diagnosis can be confirmed by serological test, B. Radiographic features are diagnostic, C. Usually a large and single abscess is seen in cases of direct spread, D. Systemic manifestations are uncommon
C: Usually a large and single abscess is seen in cases of direct spread
Answer: C: Usually a large and single abscess is seen in cases of direct spread 
Explanation: Ans. (c) Usually a large and single abscess is seen in cases of direct spread* Pyogenic Liver abscess - Serology is not useful* Radiographic Features are not diagnostic.* Systemic manifestations are common.* MC type is Solitary and Large abscess due to Direct spread from Cholecystitis, Empyema Chest and Perinephric Abscess or Subdiaphragmatic collection.