This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
What does not occur in lysosomal storage disorders? 
Select and explain. 
A. Increased number and size of lysosomes, B. Lysis of the cell, C. Apoptosis of the cell, D. Accumulation of the polyubiquinated proteins
B: Lysis of the cell
Answer: B: Lysis of the cell 
Explanation: Ref: TEXTBOOK OF PATHOLOGY 6th EDITION - HARSH MOHAN PAGE NO: 261 TABLE 10.2: Storage Diseases (Inborn Errors of Metabolism). Lysosomal storage disorders: * Inherited * Mutation in genes that code lysosomal hydrolases. * Lysosomal enzymes are used for the intracellular digestion/degradation of many complex biological macromolecules. * Deficiency of lysosomal enzymes: Inherited deficiency of lysosomal enzyme may cause incomplete catabolism of its normal macromolecular substrate. This can lead to the accumulation of the paially degraded insoluble substrate within the lysosomes. The inherited disorders result from mutations in genes that encode lysosomal hydrolases are known as lysosomal storage disorders.