This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
All of the following cause intravascular hemolysis, Except: 
Select and explain. 
A. Mismatched Blood transfusion, B. Snake bite, C. Thalassemia, D. Paroxysmal Nocturnal Hemoglobinuria (PNH)
C: Thalassemia
Answer: C: Thalassemia 
Explanation: Answer is C (Thalassemia) Hemoglobinopathies including thalassemia cause extravascular hemolysis and not intravascular hemolysis. Causes of intravascular hemolysis Blood transfusion - ABO mismatched transfusion - Infected blood Thermal burns Snake bites Sepsis - Bacterial / parasitic infections - Clostridial sepsis - Malaria - Baonellosis - Mycoplasma pneumoniae Mechanical hea valves Paroxysmal hemoglobinuria - PNH - PCH Causes of extravascular hemolysis Blood and viral infections - Malaria - Mycoplasma pneumoiae - Infectious mononucleosis Drug-induced hemolysis - G6PD/GSH deficiency - Autoimmune drug reactions - Strong oxidant drugs/chemicals Autoimmune hemolysis - Warm-reacting (IgG) AIHA - Cold-reacting (IgM) AIHA Hemoglobinopathies - Thalassemia Membrane structural defect - Hereditary sperocytosis - Hereditary spherocytosis - Acanthocytosis Environmental disorders - Malignancy/D1C - TTP/HUS