This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
AKT1 E17K somatic mutation is associated with 
Select and explain. 
A. Gastric carcinoma, B. Breast carcinoma, C. Ovarian carcinoma, D. Pancreatic carcinoma
B: Breast carcinoma
Answer: B: Breast carcinoma 
Explanation: AKT1 is a member of the serine-threonine kinase class that plays a key role in cellular processes, including growth, proliferation, survival, and angiogenesis. It is a downstream mediator of phosphatidylinositol 3-kinase which, along with AKT1, is a key mediator of proliferation and survival pathways frequently activated in cancer .The single hotspot mutation AKT1 has been described in several cancers, with the highest incidence observed in breast cancer.