This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diagnosis in obstetrics, Subject name: Gynaecology & Obstetrics
About AFP all are true except: 
Select and explain. 
A. MSAFP detected 16-18 weeks of gestation, B. Diabetic patients have increased AFP level, C. MSAFP is unrelated to period of gestation, D. Decreased in down syndrome
B: Diabetic patients have increased AFP level
Answer: B: Diabetic patients have increased AFP level 
Explanation: AFP increased in wrong gestational age Rh isoimmunisation open neural tube defects multiple pregnancy IUFD Anterior abdominal wall defects renal anomalies D.C.DUTTA'S TEXTBOOK OF OBSTETRICS,Pg no:106,7th edition and refer to previous question