This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Targeted Anticancer Drugs and Immunosuppressants, Subject name: Pharmacology
Ibrutinib drug is used in all except: 
Select and explain. 
A. Mantle cell lymphoma, B. Chronic lymphocytic leukemia, C. Waldenstrom's macroglobulinemia, D. AML
D: AML
Answer: D: AML 
Explanation: Bruton tyrosine kinase (BTK) is a validated target for B cell malignancies. BTK inhibitor ibrutinib was approved in: - Chronic lymphocytic leukaemia- Mantle cell lymphoma- Waldenstrom's macroglobulinemia NIB -drug ending with NIB are kinase inhibitor BRUT - Bruton's tyrosine kinase inhibitor