This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
The rate-limiting step in cholesterol synthesis is inhibited by: 
Select and explain. 
A. Probucol, B. Cholestyramine, C. statins, D. Gemfibrozin
C: statins
Answer: C: statins 
Explanation: HMG-CoA is the rate-limiting enzyme in the biosynthesis of cholesterol. Lovastatin and its congeners are structurally similar to HMG-CoA and are therefore competitive inhibitors of the enzyme HMC-COA. They r considered the drug of choice for hyperlipidemias 1 and 3 Cholestyramine is a bile acid binding resin. Probucol is an antioxidant and gemfibrozil is a fibrc acid derivative. Ref: KD Tripathi 8th ed.