This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Regarding opioid induced seizures: 
Select and explain. 
A. They usually occur at therapeutic doses, B. Children are more susceptible, C. Seizures occur only with u-opioid agonists, D. Diazepam is the drug of choice in treatment
B: Children are more susceptible
Answer: B: Children are more susceptible 
Explanation: Controlled-release oxycodone-induced seizures. ... However, opioid-related seizure in patients with epilepsy or other conditions that may decrease seizure threshold has been described in the literature; in paicular, oxycodone has been associated with seizure in a patient with acute renal failure Ref KD Tripathi 8th ed,