This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Loading drug of dose primarily depends on 
Select and explain. 
A. Volume of distribution, B. Clearance, C. Rate of administration, D. Half life
A: Volume of distribution
Answer: A: Volume of distribution 
Explanation: Loading dose; This is a single or few quickly repeated doses given in the beginning to attain target concentration rapidly.
Loading dose = Target Cp * V /F
Cp - concentration, V - volume of distribution, F - oral bioavailability
Thus, the loading dose is governed only by V and not by Clearance or t1/2