This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipids, Subject name: Biochemistry
Niemann-Pick disease is characterized by: 
Select and explain. 
A. Increased concentration of sphingomyelin in liver, B. Increased concentration of cerebrosides in liver and spleen., C. Increased concentration of plasminogen, D. Increased accumulation of glycerol in liver
A: Increased concentration of sphingomyelin in liver
Answer: A: Increased concentration of sphingomyelin in liver 
Explanation: Ans. A. Increased concentration of sphingomyelin in liverNiemann -pick disease is due to the absence of sphingomyelinase enzyme which leads to the accumulation of sphingolipids or sphingomyelin in liver.