This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Pharmacology), Subject name: Pharmacology
All have high hepatic clearance EXCEPT 
Select and explain. 
A. Labetalol, B. Simvastatin, C. Morphine, D. Paracetamol
D: Paracetamol
Answer: D: Paracetamol 
Explanation: (D) Paracetamol HEPATIC CLEARANCE OF DRUGSLOWHepatic ClearanceINTERMEDIATEHepatic ClearanceHIGHHepatic Clearance* Carbamazepine* Caffeine* Lignocaine* Diazepam* Fluoxetine* Morphine* Ibuprofen* Midazolam* Pethidine* Phenytoin* Omeprazole* Propranolol* Warfarin* Paracetamol* Zidovudine> Low Hepatic Clearance does not mean that the drug is then cleared by the kidneys; it indicates that the capacity of the hepatic enzymes involved in the metabolism of the drug is low.