This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
In a patient with nephrotic syndrome and hypoalbuminemia,protein binding of which drug will not be affected 
Select and explain. 
A. Tolbutamide, B. Morphoine, C. Diazepam, D. Valproate
A: Tolbutamide
Answer: A: Tolbutamide 
Explanation: all drugs listed in the optiond are highly plasma protein bound(>90%)whereas morphine has only 35% binding to plasma proteins. Moreover ,morphine is a basic drug and binds to alpha1 -acid glycoprotein(not album)