This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
HPV-related cervical intraepithelial neoplasia can be diagnosed by the presence of which of the following histologic features?(NOT RELATED-PATHOLOGY) 
Select and explain. 
A. Central, basophilic intranuclear cellular inclusions, B. Cowdry type A intranuclear cellular inclusions, C. Enlarged multinucleated cells, D. Cytoplasmic vacuolization and nuclear enlargement of cells
D: Cytoplasmic vacuolization and nuclear enlargement of cells
Answer: D: Cytoplasmic vacuolization and nuclear enlargement of cells 
Explanation: HPV produces characteristic cytoplasmic vacuolization and nuclear enlargement of squamous epithelial cells referred to as koilocytosis. Both Cowdry type A intranuclear inclusions and enlarged multinucleated cells can be seen with herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections; central, basophilic intranuclear inclusion bodies are seen in CMV infections, whereas the presence of atypical lymphocytes is seen specifically in Epstein-Barr virus (EBV) infections.