This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
Autosplenectomy is seen in? 
Select and explain. 
A. Hereditary spherocytosis, B. G6 PD deficiency, C. Sickle cell anemia, D. Thalassemia major
C: Sickle cell anemia
Answer: C: Sickle cell anemia 
Explanation: ANSWER: (C) Sickle cell anemiaREF: Harrisons Internal Medicine 17th edition Chapter 60. Enlargement of Lymph Nodes and Spleen, CMDT 2009 chapter 13 Blood Disorders > AnemiasPatients with sickle cell disease often suffer from autosplenectomy as a result of splenic destruction by the numerous infarcts associated with sickle cell crises during childhood.Indeed, the presence of a palpable spleen in a patient with sickle cell disease after age 5 suggests a coexisting hemoglobinopathy, e.g., thalassemia or hemoglobin C