This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Primary Immunodeficiency, Subject name: Pediatrics
Most sensitive antibody for SLE: 
Select and explain. 
A. Anti-nuclear, B. Anti-ds DNA, C. Anti-Smith, D. Anti-histone
A: Anti-nuclear
Answer: A: Anti-nuclear 
Explanation: Autoantibodies in Systemic Lupus Erythematosus (SLE) Antibody Clinical Utility Antinuclear antibodies Best screening test/Most sensitive Anti-ds DNA Specific, correlate with disease activity, nephritis, vasculitis Anti-Sm Most Specific for SLE, marker for CNS lupus Anti-RNP Not specific for SLE Anti-Ro/La (SS-A) Sicca syndrome, neonatal lupus with congenital hea block Anti-histone Drug-induced lupus