This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
Thrombomodulin-thrombin complex produces its anticoagulant effect by- 
Select and explain. 
A. Inactivating factor V and VIII, B. Inactivating protein C, C. Inactivating protein S, D. Inactivating factor VIII
A: Inactivating factor V and VIII
Answer: A: Inactivating factor V and VIII 
Explanation: Thrombomodulin Present on the endothelial cells and binds to thrombin and activates protein C, which inhibits clotting by proteolysis of factor Va and VIIIa. Ref: RAM DAS NAYAK 2nd Ed. Pg 89