This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
A drug X is useful in the treatment of rheumatoid ahritis. It is available only in parenteral formulation and its mechanism of action is antagonism of tumor necrosis factor. Which of the following can be X? 
Select and explain. 
A. Cyclosporine, B. Penicillamine, C. Phenylbutazone, D. Etanercept
D: Etanercept
Answer: D: Etanercept 
Explanation: Infliximab and Etanercept are TNF-aantagonists useful for the treatment of rheumatoid ahritis. These are administered by parenteral route. TNF-a antagonists can cause reactivation of latent tuberculosis. Phenylbutazone -can precipitate the acute attack of asthma