This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Orthopaedics
Three most common cancers metastasizing to bone -a) Kidneyb) Thyroidc) Breastd) Prostatee) Lung 
Select and explain. 
A. abd, B. cde, C. bde, D. ade
B: cde
Answer: B: cde 
Explanation: Certain tumors are known to be common sources of bone metastasis. The following primary tumors are the most common to metastasize in the bone; breast, prostate, lung, thyroid, kidney, and gastrointestinal tract.
The commonest source of metastatic bone disease is carcinoma of the breast. In males most common source is prostate carcinoma.
Bladder and uterine carcinomas are less common sources.
In children, skeletal metastases originate from neuroblastoma, Ewing's sarcoma, and osteosarcoma.