This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S., Subject name: Pediatrics
Indomethacin causes: 
Select and explain. 
A. Closure of ductus in premature neonate, B. Patent ductus arteriosus, C. Closure of ductus in term & premature neonates, D. Closure of ductus in older children also
A: Closure of ductus in premature neonate
Answer: A: Closure of ductus in premature neonate 
Explanation: a. Closure of ductus in premature neonate(Ref: Nelson's 20/e p 2197)Indomethacin, a Prostaglandin inhibitor is used in medical closure of Ductus arteriosus in preterm neonates with PDA.