This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Steroid resistant nephritic syndrome is caused by mutation in which of the following? 
Select and explain. 
A. Nephrin, B. Alpha-actinin-4, C. Podocin, D. Transient Receptor Potential 6
C: Podocin
Answer: C: Podocin 
Explanation: A mutation in the Nephrin (NPHS1) gene causes a hereditary form of congenital nephrotic syndrome with minimal change glomerular morphology whereas mutations in NPHS2 encoding for podocin results in steroid resistant nephrotic syndrome. Ref: Robbins 7Th Ed Page 981, 983.