This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
With Intracytoplasmic sperm injection, which of the following step in fertilization is skipped? 
Select and explain. 
A. Sperm-oocyte binding, B. Zona reaction, C. Acrosome reaction, D. Cortical reaction
C: Acrosome reaction
Answer: C: Acrosome reaction 
Explanation: With ICSI method, acrosome reaction is skipped.