This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
In tissue, Coccidioides immitis produces ? 
Select and explain. 
A. Spherules and endospores, B. Encapsulated yeast cells, C. Fine, delicate hyphae, D. Coarse, septate hyphae
A: Spherules and endospores
Answer: A: Spherules and endospores 
Explanation: Ans. is 'a' i.e., Spherules and endospores Coccidioides immitis . It is a dimorphic fungus with septate hyphae. . Has two forms. White fluffy mould on most culture media Nonbudding spherical form-a spherule, in host tissue. . C. immitis reproduces in host tissue by forming small endospores within mature spherules. . Fungus is identified by its appearance by the formation of thick-walled barrel shaped spores, called ahrospores. . Infection is acquired by dust containing ahrospores. . Clinical manifestations - Most of the infections are asymptomatic Asymptomatic pulmonary nodule. - Many persons develop a self limited influenza like fever --> Valley fever or dese rheumatism. - Acute pneumonia - Chronic fibrocavitatory pneumonia - Chronic dissemination: Bone Meninges Skin Joints Subcutaneous tissue