This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Classical markers for Hodgkin&;s disease- 
Select and explain. 
A. CD 15 and CD 30, B. CD 15 and CD 22, C. CD 15 and CD 20, D. CD 20 and CD 30
A: CD 15 and CD 30
Answer: A: CD 15 and CD 30 
Explanation: Immunophenotyping of RS cells reveals monoclonal lymphoid cell origin of RS cell from B cells of the germinal centre in most subtypes of Hodgkin&;s disease. RS cells in all types of HD, except lymphocyte predominance type express immunoreactivity for CD15 and CD30.Therefore they ard considered as the classical markers for HD. REFERENCE; Harsh Mohan textbook of pathology,7th edition.Pg no.349