This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
The poor prognostic factor associated with ALL in children is - 
Select and explain. 
A. Total leucocyte count 4000-10000, B. Age more than 2 years, C. Testicular involvement, D. Female gender
C: Testicular involvement
Answer: C: Testicular involvement 
Explanation: High risk factors in ALL are age belw 1yr & more than 10 yr, male gender, wbc count more than 50,000/cubic millimeter .,massive hepatomegaly,lymphadenopathy,mediastinal mass,central nervous system leukemia ,mature B cell as phenotype,hypodiploidy.Reference :Op Ghai essentials of pediatrics 8th edition pg no 601.