This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
In chronic Hepatitis B infection, which one of the following markers is indicative of active viral replication and the corresponding risk of disease transmission? 
Select and explain. 
A. Hbe antigen, B. HBs antigen, C. Anti - Hbe, D. Anti - HBs
A: Hbe antigen
Answer: A: Hbe antigen 
Explanation: HBeAg indicates active intrahepatic viral replication, reflecting high infectivity REF:<\p> ANATHANARAYANAN MICROBIOLOGY NINTH EDITION PAGE.547