This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
What is the probable diagnosis in a patient with a dilated pupil not responsive to 1% pilocarpine 
Select and explain. 
A. Diabetic third nerve palsy, B. Ade's pupil, C. Uncal Herniation, D. Pharmacological block
D: Pharmacological block
Answer: D: Pharmacological block 
Explanation: Refer Goodman and Gilman 12e 1777 Looking at the option one by one diabetic third nerve palsy: third Nerve Palsy due to any reason will result in mydriasis( because oculomotor people milk supplies constrictor pupillae). As only one nerve is destroyed and but the receptors remain intact , so it will respond to 1% pilocarpine anthers miosis will occur adie's tunic pupil: it manifests as the denervation super sensitivity. Normal people respond to 1% pilocarpine but does not contract with highly diluted solution may also result in constriction Uncal herniation : IT results in pressure on 3rd cranial nerve and presents as dilated pupil but it will respond to pilocarpine as the receptors are intact