This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In Wilms tumor, the following leads to the emergence of resistance to chemotherapy - 
Select and explain. 
A. Nephrogenic rests, B. Monophasic morphology, C. Anaplasia, D. Capsular infiltration
C: Anaplasia
Answer: C: Anaplasia 
Explanation: None