This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Non professional antigen presenting cell is A/E – 
Select and explain. 
A. Red blood cells, B. Endothelial cell, C. Epidermal cell, D. Fibroblasts
A: Red blood cells
Answer: A: Red blood cells 
Explanation: Non-professional antigen presenting cell
o A non-professional APC does not constitutively express the Major Histocompatibility Complex class II
(MHC class II) proteins required for interaction with naive T cells; these are expressed only upon
Stimulation of the non- professional APC by certain cytokines such as IFN-γ.
 All nucleated cells express the Major Histocompatibility Complex class I necessary to be considered a
Non- professional APC.
 As erythrocytes do not have a nucleus, they are one of the few cells in the body that cannot display
Antigens.