This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
First change seen in acute inflammation is: September 2009 
Select and explain. 
A. Increased permeability, B. Vasodilation, C. Neutrophil migration, D. Vasoconstriction
D: Vasoconstriction
Answer: D: Vasoconstriction 
Explanation: Ans. D: Vasoconstriction Cardinal signs: Rubor (redness) due to dilatation of aerioles Calor (heat) Dolor (pain) due to pressure on nerve endings by edema fluid and chemical mediator bradykinine Tumor (swelling) due to edema. Functio laesa (loss of function) due to inhibition of movement by pain and tissue necrosis.