This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The Most common gene defect in "Idiopathic Steroid Resistant Nephrotic Syndrome": 
Select and explain. 
A. ACE, B. NPHS 2, C. HOX 11, D. PAX
B: NPHS 2
Answer: B: NPHS 2 
Explanation: NPHS 2