This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
Antihypeensive drug that causes coombs test positive is 
Select and explain. 
A. Methydopa, B. Clonidine, C. Hydralizine, D. Sodium nitroprusside
A: Methydopa
Answer: A: Methydopa 
Explanation: Refer kDT 6/e p547 Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to apositive direct antiglobulin test (DAT) and hemolytic anemia. ... Her mother had the history of taking methyldopain her pregnancy.