This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
In Raynaud's disease true is : 
Select and explain. 
A. Lower limb more commonly involved than upper limb, B. More common in female, C. Sup. thrombophlebitis, D. Associated with migraine
B: More common in female
Answer: B: More common in female 
Explanation: Ans. is 'b' i.e. More common in female Raynaud's disease The diagnosis of Raynaud's ds. is made when the secondary causes of Raynaud's phenomenon are ruled out. Over 50% of pts. with Raynaud's phenomenon have Raynaud's ds. Ds. is more common in female (M : F ratio is 1 : 5) Age of presentation - 20 to 40 yrs. Fingers are involved more frequently than toes Rarely earlobes and tip of the nose may be involved Raynaud's phenomenon occurs frequently in patients who also have migraine headaches or variant angina. These associations suggest a common predisposing cause for the vasospasm On physical examination the pts. are often entirely normal. The radial, ulnar and the pedial pulses are normal. Sclerodactyly (thickening and tightening of the digital subcutaneous tissue) may develop in few pts. In general, pts. with Raynaud's disease appear to have a milder form of Raynaud's phenomenon. Fewer than 1% of these patients lose a pa of digit.