This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
Michalis Gutmann bodies are seen in 
Select and explain. 
A. Xanthogranulomatous pyelonephritis, B. Malakoplakia, C. Nail patella syndrome, D. Chronic pyelonephritis
B: Malakoplakia
Answer: B: Malakoplakia 
Explanation: Malakoplakia *Etiology : Inflammation due to chronic bacterial infection, mostly by E.coli and proteus.*Common in immunosuppressed individuals*Pathogenesis : Disturbed phagocytic activity due to overloaded bacteria within macrophages*Sites : Urinary bladder, Colon, Lungs,Bones, Kidneys, prostate and epididymis *Microscopic findings : Sheets of macrophages, giant cells and michaelis-gutmann bodies *Michaelis gutmann bodies - Laminated mineralized concretions resulting from deposition of calcium In enlarged lysosomes of macrophages (Ref: Robbins 8/e p975)