This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Medicine
Swollen neurons that contain numerous lysosomes filled with lipid are typical of 
Select and explain. 
A. Amyloidosis, B. Huntington Disease, C. Kuru, D. Tay-Sachs Disease
D: Tay-Sachs Disease
Answer: D: Tay-Sachs Disease 
Explanation: Swollen neurons that exhibit marked vacuolization of the perikaryon and contain lysosomes filled with lipid are found in TaySachs disease but could occur in other lipid-storage diseases as well. The correct diagnosis can be established by biochemical analysis of the stored material or identification of intermediary metabolites and missing enzymes. The other diseases listed do not produce such neuronal changes. Ref - Harrison's internal medicine 20e pg 3007