This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2019, Subject name: Medicine
Preferred insulin regimen during pregnancy? 
Select and explain. 
A. Insulin Regular + NPH, B. Insulin NPH + Lispro, C. Insulin Degludec, D. Insulin Lispro + Insulin regular
B: Insulin NPH + Lispro
Answer: B: Insulin NPH + Lispro 
Explanation: For basalinsulincoverage, intermediate-acting neutralprotamineHagedorn (NPH)insulinhas historically been considered first-line therapy and has been widely studied in this patient population. For postprandial glycemic control, rapid-actinginsulinanalogues, such asinsulinlispro andinsulin aspa, do not cross the placenta and have been safely used in pregnancy.