This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Mechanism of action of paclitaxel is - 
Select and explain. 
A. Topoisomerase inhibition, B. Increases the polymerization of tubulin, C. Inhibits protein synthesis, D. Alkylation of DNA
B: Increases the polymerization of tubulin
Answer: B: Increases the polymerization of tubulin 
Explanation: Ans. is 'b' i.e., Increases the polymerization of tubulin o Paclitaxel and docetaxel function as a mitotic spindle poison through high affinity binding to microtubules with enhancement of tubulin polymerization. o The microtubules are stabilized and their depolymerization is prevented inhibition of mitosis and cell division.