This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Psychiatric Illness, Subject name: Pharmacology
Major mechanism of action of typical anti-psychotic drugs is:- 
Select and explain. 
A. Dopamine D1 receptor blockade, B. Dopamine D2 receptor blockade, C. Dopamine D3 receptor blockade, D. Dopamine D4 receptor blockade
B: Dopamine D2 receptor blockade
Answer: B: Dopamine D2 receptor blockade 
Explanation: Antipsychotic drugs are divided into typical and atypical. Typical antipsychotic drugs mainly act by blocking D2 receptors of dopamine. Atypical drugs mainly act by blocking 5HT2 receptors of serotonin.