This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
The peripheral smear of Hereditiary spherocytosis will show spherocytes - 
Select and explain. 
A. Usually of same size as RBCs, B. Reticulocytosis absent, C. Anemia is negligible, D. Smaller size than RBCs
D: Smaller size than RBCs
Answer: D: Smaller size than RBCs 
Explanation: Various mutations involving membrane skeletal proteins weakens interactions b/w proteins and cause red cells to lose memb fragments . This causes decrease in size of the spherocytes compared to normal RBCs Ref: Robins 9/e pg:632