This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Transcription, Subject name: Biochemistry
True about RIBOZYME: (AllMS Nov 2013, Nov 2012) 
Select and explain. 
A. Peptidyl transferase activity, B. Cut DNA at specific site, C. Participate in DNA synthesis, D. GTPase activity
A: Peptidyl transferase activity
Answer: A: Peptidyl transferase activity 
Explanation: Ans. a. Peptidyl transferase activity (Ref: Harper 28/e p363; 27/e p364; Lippincott 4/435-439, Lehninger 5/e p1078)Ribozymes are RNA molecule with catalytic activityQ. Ribozymes play a central role in peptide bond formation (peptidyl transferase activity).RibozymeRibozymes are RNA molecules with catalytic activityQ.These generally involve transesterification reactions, and most are concerned with RNA metabolism (splicing and endoribonuclease).Recently, a ribosomal RNA component was noted to hydrolyze an aminoacyl ester and thus play a central role in peptide bond formation (peptidyl transferase)Q.