This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Dent's disease is characterized by all except 
Select and explain. 
A. Chloride channel defect, B. Males are affected, C. Nephrolithiasis, D. Defect in limb of Loop of Henle
D: Defect in limb of Loop of Henle
Answer: D: Defect in limb of Loop of Henle 
Explanation: Answer- D. Defect in limb of Loop of HenleDent's disease refers to heterogenous group of X-linked disorders. It b characterized by manifestations of proximal tubule dysfunction (PT) dysfunction associated with hypercalciuria nephrolithiasis, nephrocalcinosis and progressive renalfailureThese features are found in males only.mutation in gene encoding CLS-S, a Voltage gated Chloide channel.