This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: CHF, Angina Pectoris and Myocardial Infarction, Subject name: Pharmacology
The most impoant channel of elimination of digoxin is: 
Select and explain. 
A. Glomerular filtration, B. Tubular secretion, C. Hepatic metabolism, D. Excretion in bile
A: Glomerular filtration
Answer: A: Glomerular filtration 
Explanation: Digoxin is primarily eliminated unchanged by glomerular filtration Digitoxin is eliminated by hepatic metabolism.