This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Auto Immune Disorders Introduction, Subject name: Pathology
Wire loop lesion seen in lupus nephritis is due to 
Select and explain. 
A. Capillary wall thickening, B. Basement membrane thickening, C. Subepithelial deposits, D. Sclerosis of mesangium
A: Capillary wall thickening
Answer: A: Capillary wall thickening 
Explanation: Subendothelial immune complex deposits may create a circumferential thickening of the capillary wall, forming "wire loop" structures on light microscopy. This condition is seen in lupus nephritis. 50% of SLE patients have clinically significant renal involvement Currently there are six pattern of glomerular disease Where, Class 1(Minimal mesangial lupus nephritis) is least common and class 4(Diffuse lupus nephritis) is most common