This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Cytokines are secreted in sepsis and Systemic Inflammatory Response syndrome (SIRS) by - 
Select and explain. 
A. Neutrophils, B. Adrenal, C. Platelets, D. Collecting duct
A: Neutrophils
Answer: A: Neutrophils 
Explanation: Cytokine release in Sepsis 

The mechanism by which endotoxin causes activation of inflammatory cells and release of cytokines has already been explained earlier.
It is by TL -4 and CD-14 mediated.
Signals from TLR-4 can directly activate vascular endotheliun and leukocytes to release cytokine mediators.
The major cells that secrete cytokines in sepsis area


Monocyte/Macrophages       
Neutrophils                    
Endothelial cells


Cytokine mediators involved are:-


TNF - (The most important cytokine in sepsis)               
IL-1                    
IL-6       
IL-8               
NO.