This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Predict the effect of aldosterone hypersecretion on body fluid pH and electrolytes ? 
Select and explain. 
A. pH decreased, K+ decreased, Na+ increased, B. pH increased, K+ decreased, Na+ increased, C. pH decreased, K+ increased, Na+ decreased, D. pH increased, K+ increased, Na+ decreased
B: pH increased, K+ decreased, Na+ increased
Answer: B: pH increased, K+ decreased, Na+ increased 
Explanation: Aldosterone increases the rate of sodium absorption and potassium secretion by the kidneys, but in high concentrations aldosterone also stimulates hydrogen ion secretion. Therefore elevated aldosterone levels such as occur in patients with Cushing's syndrome can elevate body fluid pH above normal (alkalosis). The major factor that influences the rate of hydrogen ion secretion, however, is pH of the body fluids. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 20. The Adrenal Medulla & Adrenal Coex. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.