This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
True statement about neostigmine aa 
Select and explain. 
A. It is quaternary Ammonium compounds, B. It is metabolized by liver, C. It can cross blood brain barrier, D. Prominent effect on cardiac muscle
A: It is quaternary Ammonium compounds
Answer: A: It is quaternary Ammonium compounds 
Explanation: Refer kDT 6/e p 101,102 neostigmine is a reversible cholinesterase inhibitor. It is a quaernary ammonium compound(lipid insoluble agent) So it doesn't cross blood brain barrier It is paly hydrolysed by serum cholinesterase and paly excreted unchanged by the Kidneys It possesses some agonistic action on Nm receptors