This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Stomach & Duodenum, Subject name: Surgery
PPI's for peptic ulcer disease should be taken: 
Select and explain. 
A. Before breakfast, B. After breakfast, C. After lunch, D. After dinner
A: Before breakfast
Answer: A: Before breakfast 
Explanation: Ans. (a) Before breakfastRef: Sabiston 19th Edition, Page 1194* PPI need acid environment to become activated. Hence given in empty stomach preferably before breakfast.* Antacids and H2 blockers must not be used with PPI.