This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
Cause ofvasodilatation in spider nevi- 
Select and explain. 
A. Estrogen, B. Testosterone, C. Hepatotoxins, D. FSH
A: Estrogen
Answer: A: Estrogen 
Explanation: The dilation, in turn, is caused by increased estrogen levels in the blood. Individuals with significant liver disease also show many spider angiomas, as their liver cannot metabolize circulating estrogens, specifically estrone, which derives from the androgen androstenedione. Ref Davidson edition23rd pg 869