This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Infection, Subject name: Pediatrics
Which of the following drugs are indicated for management of severe malaria? 
Select and explain. 
A. Quinine, B. Artemether, C. Artesunate, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: Ans. D. All of the aboveMalaria is a potentially life-threatening disease caused by infection with Plasmodium protozoa transmitted by an infective female Anopheles mosquito. Plasmodium falciparum infection carries a poor prognosis with a high mortality if untreated, but it has an excellent prognosis if diagnosed early and treated appropriately. Severe malaria may present with cerebral malaria, convulsions, hypoglycemia, and metabolic acidosis with respiratory distress, acute pulmonary edema, circulatory collapse, jaundice, hemoglobinuria, and hyperpyrexia. Drugs used for management of severe malaria include Quinine, artemether and artesunate.