This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
NSAID proposed to be acting inhibition of COX-3 is: 
Select and explain. 
A. Nimesulide, B. Paracetamol, C. Ketorolac, D. Rofecoxib
B: Paracetamol
Answer: B: Paracetamol 
Explanation: - Paracetamol or acetaminophen has antipyretic and analgesic activities but it lacks anti-inflammatory action. - It is presumed to become inactive by peroxides generated at the site of inflammation therefore, lacks anti- inflammatory action. - Some theories suggest that PCM acts on COX-3 receptors in brain. - A metabolite of paracetamol is assumed to work through vanilloid receptor TRPV-1.