This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following statement regarding first order kinetics is true? 
Select and explain. 
A. It is independent of plasma concentration, B. Tl/2 of the drug increases with dose, C. Clearance of the drug decreases with dose, D. A constant propoion of plasma concentration is eliminated
D: A constant propoion of plasma concentration is eliminated
Answer: D: A constant propoion of plasma concentration is eliminated 
Explanation: According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8