This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
All of the following are advantages of transdermal drug delivery systems except 
Select and explain. 
A. They produce high peak plasma concentration of the drug, B. They produce smooth and nonfluctuating plasma concentration of the drug, C. They minimize interindividual variation in the achieved plasma drug concentration, D. They avoid hepatic first pass metabolism of the drug
A: They produce high peak plasma concentration of the drug
Answer: A: They produce high peak plasma concentration of the drug 
Explanation: Ref-KDT 6/e p9 Transdermal route ts emploved for highly liid soluble drugs that can tra verse intact skin. The wize of the pores in tansdermal patch is adjusted to produce aunitorm and smouth absorption of the drug. This will thus, pro duce a delaved d smaller peak. in the plasma concentration. As the drug. is soins directly in the blood stream, tirst pass metabolism is avoided.