This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
Nieman pick disease is due to deficiency of 
Select and explain. 
A. Sphingomyelinase, B. Ceramidase, C. Galactosidase, D. Glucosidase
A: Sphingomyelinase
Answer: A: Sphingomyelinase 
Explanation: Some examples of sphingolipidoses Disease :Niemann-Pick disease Enzyme deficiency: Sphingomyelinase Lipid accumulating Sphingomyelin Clinical symptoms: Enlarged liver and spleen, mental.Ref: Textbook of Medical Biochemistry, Eighth Edition, Dr (Brig) MN Chatterjea, page no: 63 Table 4.2: