This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
Which of the following is true about non-competitive inhibition? 
Select and explain. 
A. Vmax |, no change in km, B. Vmax |, no change in km, C. Both Vmax and km |, D. Both Vmax and km |
A: Vmax |, no change in km
Answer: A: Vmax |, no change in km 
Explanation: Ans: a (Vmax |. no change in km) Ref: Vasudevan, 4th ed, p. 47; 5th ed,p. 46In non competitive inhibition there is no change in km value but Vmax |.Difference between competitive and non competitive inhibition Competitive inhibitionNon competitive inhibitionActing onActive siteMay or may notStructure of inhibitorSubstrate analogueUnrelated moleculeInhibition isExcess substrateKmVmaxReversibleInhibition relievedIncreasedNo changeIrreversibleNotNo changeDecreased