This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Common variable hypogammaglobulinemia shows ? 
Select and explain. 
A. Decreased B cell count, B. Increased B cell count, C. Compliment opsinization, D. Neutropenia
C: Compliment opsinization
Answer: C: Compliment opsinization 
Explanation: Ans. is 'c' i.e., Normal B cells o Most patients with common variable immunodeficiency have normal or near-normal numbers of B cells in the blood and lymphoid tissues. o These B cells, however, are not able to differentiate into plasma cells. o The clinical manifestations are caused by antibody deficiency. o The feature common to all patients is hypogammaglobulinemia, generally affecting all the antibody classes but sometimes only IgG.