This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Most characteristic features of actual inflammation in- 
Select and explain. 
A. Vasoconstriction, B. Vascular stasis, C. Vasodilation and increased vascular permeability, D. Margination of leukocytes
C: Vasodilation and increased vascular permeability
Answer: C: Vasodilation and increased vascular permeability 
Explanation: EFFECTS OF VARIOUS MEDIATORS
o Various effects of inflammatory mediators are
1. Increased vascular permeability Histamine, serotonin (5-hydroxytryptamine), anaphylatoxins (C3a, C4a, C5a), PAF, leukotrienes (LTC4, D4, E4), bradykinin.
□ PAF is the most potent one to increase permeability.
2. Chemoattractant C5a (most potent), IL-8, LTB4, PAF, bacterial products, Lymphokine, Kallikrein.
□ C5a is the most potent chemoattractant.
3. Vasodilatation Histamine, prostaglandins (PG D2, PGE2), prostacyclin (PGI2), serotonin. Nitric oxide, bradykinin.
4. Vasoconstriction Leukotrienes (LTC4, D4, E4), Thromboxane A2.
5. Bronchoconstriction Leukotrienes (LTC4, D4, E4), PFA, histamine, bradykinin.
□ Leukotrienes (LTC4, D4, E4) are the most potent bronchoconstrictors.
6. Pain Prostaglandins, bradykinin.
7. Fever (pyrogens) IL-1, TNF-αl IL-6, prostaglandins, interferon.