This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacterial infections, Subject name: Dental
Michaelis Gutmann bodies are seen in 
Select and explain. 
A. Brucellosis, B. Melioidosis, C. Tularemia, D. Malakoplakia
D: Malakoplakia
Answer: D: Malakoplakia 
Explanation: Michaelis guttman bodies (malacoplakia) # Chronic granulomatous infection as a result of the inability of macrophages to kill phagocytosed E. coli. # Most commonly affects immunosuppressed(BMT> HIV/AIDS) # Most commonly affects GU tract; may affect skin of perianal/genital region (ulcerated abscesses and soft polypoid lesions) Histology:- Dense granulomatous infiltrate comprised of von Hansemann cells (large macrophages w/ eosinophilic cytoplasm) containing Michaelis Gutmann bodies (round, laminated, calcified basophilic intracytoplasmic inclusions; comprised of incompletely killed bacteria within calcified phagolysosomes; stain w/ von Kossa, PAS, Perls, Giemsa). Treatment:- * Localized: surgical excision * Nonsurgical candidates: difficult to treat; may try long courses of ciprofloxacin, TMP/SMX, or clofazimine. Ref:- Review of Dermatology by Alikhan pg num:-298