This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Which of the following is LEAST likely to occur in leiomyoma of uterus? 
Select and explain. 
A. Red degeneration, B. Sarcomatous change, C. Fatty generation, D. Hyaline generation
B: Sarcomatous change
Answer: B: Sarcomatous change 
Explanation: Mitotic activity in leiomyomas is rare and is a key point in their differentiation from leiomyosarcoma. The typical appearance of leiomyomas may change if normal muscle tissue is replaced with various degenerative substances following hemorrhage and necrosis. This process is collectively termed degeneration, and the replacement substances dictate the naming of these degenerative types. Forms include hyaline, calcific, cystic, myxoid, carneous or red, and fatty. These gross changes should be recognized as common variants. Ref: Hoffman B.L., Schorge J.O., Schaffer J.I., Halvorson L.M., Bradshaw K.D., Cunningham F.G., Calver L.E. (2012). Chapter 9. Pelvic Mass. In B.L. Hoffman, J.O. Schorge, J.I. Schaffer, L.M. Halvorson, K.D. Bradshaw, F.G. Cunningham, L.E. Calver (Eds), Williams Gynecology, 2e.