This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Platelet & Coagulation disorders, Subject name: Medicine
Purpura fulminans is seen in? 
Select and explain. 
A. Protein C deficiency, B. Protein S deficiency, C. AT III deficiency, D. Factor 5 leiden mutation
A: Protein C deficiency
Answer: A: Protein C deficiency 
Explanation: Purpura fulminans is a severe form of DIC resulting from thrombosis of extensive areas of the skin. It predominantly affects young children following viral or bacterial infection, paicularly those with inherited or acquired hypercoagulability due to deficiencies of the components of the protein C pathway.