This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
In which of the following disorders,administration of barbiturates is contraindicated? 
Select and explain. 
A. Anxiety disorders, B. Acute intermittent porphyria, C. Kernicterus, D. Refractory status epilepticus
B: Acute intermittent porphyria
Answer: B: Acute intermittent porphyria 
Explanation: Barbiturates induce the rate limiting enzyme amino levulanic acid synthase in porphyrin synthesis. This increased synthesis of prophyrins can precipitate acute attack of AIP Ref: KD Tripathi 8th ed.