This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Heart, Circulation, and Blood, Subject name: Physiology
Which factor is not freely circulating in blood? 
Select and explain. 
A. Factor 9, B. Factor 10, C. Factor 12, D. Factor 3
D: Factor 3
Answer: D: Factor 3 
Explanation: D i.e. Factor 3Explanation:Coagulation factor III is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII.Clotting factors.Clotting factorsFactorNameDeficiency leads toIFibrinogenAfbrinogenemiaIIProthrombinHypoprothrombinemia(hemorrhagic tendency in liver disease)IIIThromboplastinOnly coagulation factor not found in the plasma*IVCalcium VProaccelerin, labile factorParahemophiliaVIIProconvertin, stable factorHypoconvertinemiaVIIIAntihemophilic factor (AHF), antihemophilic factor AHemophilia A (classic hemophilia)IXPlasma thromboplastic component (PTC), Christmas factor, antihemophilic factor BHemophilia B (Christmas disease)XStuart-Prower factorStuart-Prower factor deficiencyXIPlasma thromboplastin antecedent (PTA), antihemophilic factor CPTA deficiencyXIIHageman factor, glass factorHageman traitXIIIFibrin-stabilizing factor, Laki-Lorand factorAbnormal clot solubility