This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Nifedipine and beta-blocker are given together - 
Select and explain. 
A. To decrease pedal edema due to nifedipine, B. To overcome increased sympathetic activity of nifedipine, C. Anti CHF action of propranolol, D. Antiarrhythmic effect of nifedipine
B: To overcome increased sympathetic activity of nifedipine
Answer: B: To overcome increased sympathetic activity of nifedipine 
Explanation: Ans. is 'b' i.e., To overcome increased sympathetic activity of Nifedipine b-Blocker is given along with Nifedipine because a) Reflex tachycardia (Increased sympathetic activity) caused due to Nifedipine, is prevented by b-blocker. b) b-blockers cause dilatation of coronary aeries by unopposed a-mediated vasoconstriction. Nifedipine causes coronary vasodilatation and opposes the spasm caused by b-blockers. The tendency of b-blocker to cause ventricular dilatation is counteracted by Nifedipine.