This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
True statement regarding development of drug resistance in MRSA is? 
Select and explain. 
A. Results due to penicillinase enzyme production, B. Occurs due to change in penicillin blinding proteins, C. Chromosome mediated, D. Treated with amoxicillin + clavulanic acid
B: Occurs due to change in penicillin blinding proteins
Answer: B: Occurs due to change in penicillin blinding proteins 
Explanation: MRSA have emerged in many areas. These are insensitive to all penicillinase-resistant penicillins and to other beta-lactams as well as to erythromycin, aminoglycosides, tetracyclines, etc. The MRSA have altered PBPs which do not bind penicillins. ESSENTIALS OF MEFICAL PHARMACOLOGY page no 721