This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
All of the following drugs are used in the treatment of metastatic breast cancer except: 
Select and explain. 
A. Ixabepilone, B. Abemaciclib, C. Ribociclib, D. Sunitinib
D: Sunitinib
Answer: D: Sunitinib 
Explanation: Ixabepilone is a semisynthetic epothilone B analog that functions as a microtubule inhibitor. it is approved for metastatic breast cancer in combination with the oral fluoropyrimidine capecitabine or as monotherapy. Abemaciclib & Ribociclib are cyclin dependent kinase inhibitors (CDKI) and are given orally in breast cancer. Sunitinibis a Tyrosine kinase inhibitor and is used mainly in GIST and RCC.