This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
In which of the following condition is SHBG synthesis decreased? 
Select and explain. 
A. Hypehyroidism, B. Increased estrogen, C. Increased androgen, D. Pregnancy
C: Increased androgen
Answer: C: Increased androgen 
Explanation: Increase in androgen level is associated with decrease in SHBG synthesis. Other factors leading to decreased SHBG synthesis are: Obesity Hypothyroidism Excess glucocoicoids Also know: Factors leading to increased SHBG synthesis are: Estrogen Pregnancy Hypehyroidism Ref: Endocrine Pathophysiology, Second Edition By C. B. Niewoehner, page 285