This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
About Ramelteon, which of the following is not true? 
Select and explain. 
A. MT1 and MT2 receptor antagonist, B. Metabolized by Cytochrome p450, C. No significant addictive potential, D. Useful in long-term treatment of insomnia
A: MT1 and MT2 receptor antagonist
Answer: A: MT1 and MT2 receptor antagonist 
Explanation: Ramelteon is melatonin receptor agonist, rapidly absorbed and undergoes extensive first-pass metabolism. Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 and MT2 receptors and selec vity over the MT3 receptor.