This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Radiology Q Bank, Subject name: Radiology
26 year old civil servant, presented with a 1 month history of B/L numbness in hands and feet, fatigue and generalized weakness. She had noticed some blurred vision over the previous 2 weeks. She recalled experiencing similar but milder symptoms during the previous summer. Which of the following is most appropriate diagnosis? 
Select and explain. 
A. Multiple sclerosis, B. Alexander disease, C. Adrenoleukodystrophy, D. Krabbe's disease
A: Multiple sclerosis
Answer: A: Multiple sclerosis 
Explanation: Clinical scenario and imaging points towards diagnosis of Multiple sclerosis(MS) 1st image shows open ring/ horse shoe enhancement(suggestive of demyelination) and a T2 weighted image showing multiple hyper intense round to oval shaped lesions lying perpendicular to ventricular margin (Dawson's finger sign). All the options given are demyelinating disorders. Can be differentiated depending upon different presentations and imaging: Alexander disease: white mater dystrophy of B/L frontal lobes. Adrenoleukodystrophy:white mater of B/L occipital lobes is involved. Krabbe's disease/Globoid cell leukodystrophy : involvement of B/L thalami.