This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Link reaction, Subject name: Biochemistry
Pyruvate utilisation is decreased in: 
Select and explain. 
A. Pernicious anemia, B. Scurvy, C. Folate trap, D. Beri-beri
D: Beri-beri
Answer: D: Beri-beri 
Explanation: PDH complex requires five coenzymes - Vitamin B1, B2, B3, B5 and Lipoic acid. Vitamin B1 deficiency - Beri-beri Beri- beri - |PDH activity - | pyruvate to acetyl-CoA conversion - low pyruvate utilization Vitamins (B1, B2, B3, B5) - decreased energy production and CNS problems (brain cells depend upon this aerobic reaction)