This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Clotting factors that is not affected in liver disease is? 
Select and explain. 
A. Factors II, B. Factor IV, C. Factor IX, D. Factor VIII
D: Factor VIII
Answer: D: Factor VIII 
Explanation: Factor VIII REF: Ganong's 22nd ed p. 545 All clotting factors except VIII are produced by liver, which is produced by vascular endothelium