This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation & Repair, Subject name: Pathology
Integrin connects actin to which macromolecule in ECM? 
Select and explain. 
A. Vitronectin, B. Laminin, C. Fibronectin, D. Collagen
C: Fibronectin
Answer: C: Fibronectin 
Explanation: Ans. C. Fibronectin > LamininIntegrins localized in the plasma membrane are the major adhesion receptor connecting cells with components of the extracellular matrix. Integrins interact directly with laminin and mainly fibronectin present in the basal lamina and intracellularly contact actin through intermediate proteins, such as alpha-actinin, vinculin, and talin. Integrins are calcium-independent adhesion molecules.