This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The gene involved in GIST 
Select and explain. 
A. C-KIT, B. BRAC-1, C. p53, D. BRAC-2
A: C-KIT
Answer: A: C-KIT 
Explanation: Pathogenesis of GISTs

Approximately 75% to 80% of all GISTs have oncogenic, gain-of-function mutations of the gene encoding the tyrosine kinase c-KIT.
Approximately 8% of GISTs have mutations that activate a related tyrosine kinase, platelet-derived growth factor receptor a (PDGFRA).
Constitutively active c-KIT or PDGFRA receptor tyrosine kinases activate RAS and P13K/AKT pathways and thereby promote tumor cell proliferation.