This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
All of the following factors tend to increase the volume of distribution of a drug except 
Select and explain. 
A. High plasma protein binding, B. Low ionization at physiological pH values, C. High lipid solubility, D. High tissue binding
A: High plasma protein binding
Answer: A: High plasma protein binding 
Explanation: Ref - katzung10/e p34,35 If a drug is highly bound to plazma proteins it is more likely to statin blood. Thus its Vd will be less. Low ionizition ours the distribution of drug because unionized molecules can cross the membrane of blood vessel and tissue.