This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Musculoskeletal system, Subject name: Anatomy
In giant cell tumor of the bone.,the cell of origin is 
Select and explain. 
A. Fibroblst cells, B. Osteoclast and precursors, C. Osteoblast and precursors, D. Sinusoidal cells
C: Osteoblast and precursors
Answer: C: Osteoblast and precursors 
Explanation: The Neoplastic cells of giant cell tumor are primitive osteoblast precursors but they represent only a minority of the tumor cells.The bulk of the tumor consists of non Neoplastic osteoclast and their precursors Ref Robbins page no 1203