This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Surgery
Regarding breast cancer all are true except: 
Select and explain. 
A. Increased incidence with increase in age, B. Medullary carcinoma with high mitotic index has poorest prognosis, C. Involvement of subdermal lymphatics carries poor prognosis, D. Increase in incidence with estrogen exposure
B: Medullary carcinoma with high mitotic index has poorest prognosis
Answer: B: Medullary carcinoma with high mitotic index has poorest prognosis 
Explanation: Most impoant risk factor for malignancy: Increasing Age Most conspicuous sign of Breast Cancer: Peau D Orange- cause is lymphatic permeation by tumor cells -increase risk of lymph node metastasis - increases risk of distant metastasis Hyperestrogenemia like in nulliparity late first full-term pregnancy, early menarche, late menopause - increases risk of Breast Cancer Type of Breast Cancer with worst /poorest prognosis - Inflammatory Breast Cancer Aka Mastitis Carcinomatosa