This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
True about Congenital Rubella syndrome is 
Select and explain. 
A. It will become a chronic infection, B. Virus can be isolated only upto 6months after bih, C. Triad of CRS are cataract, cardiac defects, cerebral palsy, D. Infection is most serious after five months of pregnancy
A: It will become a chronic infection
Answer: A: It will become a chronic infection 
Explanation: * Rubella infection gets transmitted by veical transmission and bih defects is more common when acquired during first trimester of pregnancy. * Bih defects are uncommon when infection is acquired after 20 weeks of gestation. * Congenital Rubella syndrome leads to cardiac defects, cataract and deafness; (Classical triad). Other manifestations are hepatosplenomegaly, thrombocytopenic purpura, myocarditis and bone lesions. * Intrauterine infection of Rubella is associated with chronic persistence of disease. * Viral detection can be done in all fluids and it is excreted upto 12-18 months of age. Ref:- Jawetz TB of medical microbiology 27th edition; pg num:- 597