This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
Hand and foot syndrome is an adverse effect of: 
Select and explain. 
A. 5-Fluorouracil, B. Bleomycin, C. Etoposide, D. Actinomycin D
A: 5-Fluorouracil
Answer: A: 5-Fluorouracil 
Explanation: Capecitabine and 5-FU can cause hand and foot syndrome. Diarrhea is the most common adverse effect of 5-FU. 5-FU can also cause bone marrow suppression. Drugs commonly implicated are: Capecitabine 5-Fluorouracil Cytarabine Pemetrexed Doxorubicin