This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Surgery, Subject name: Surgery
All of the following are false regarding Vacuum assisted closure Except - 
Select and explain. 
A. Due to negative pressure , bacterial counts decrease and cell proliferation increases in the wound., B. Continuous pressure of +125 mm hg is applied., C. It causes interstitial edema , thereby increasing blood flow and better healing., D. Suitable to be used over malignancy if present in wound.
A: Due to negative pressure , bacterial counts decrease and cell proliferation increases in the wound.
Answer: A: Due to negative pressure , bacterial counts decrease and cell proliferation increases in the wound. 
Explanation: VACUUM ASSISTED CLOSURE/NEGATIVE PRESSURE WOUND THERAPY(NPWT) NPWT promotes wound healing by applying a vacuum through a special sealed dressing. Continued vacuum draws out the fluid (interstitial fluid) from wound and increase blood flow to the area. As a result, bacterial counts decrease and cell proliferation increases, thereby creating a suitable bed for graft or flap cover. Intermittent negative pressure of -125 mm Hg appears to hasten debridement and formation of granulation tissue in chronic wounds and ulcers. Contraindications for NPWT Use Malignancy in the wound Untreated osteomyelitis Non-enteric & unexplored fistula Necrotic tissue with eschar