This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Gynaecology & Obstetrics
Kallmans syndrome is associated with all of the following except 
Select and explain. 
A. Amenorrhea, B. Excess stimulation of the HPO axis, C. Genetic mutation, D. Anosmia
B: Excess stimulation of the HPO axis
Answer: B: Excess stimulation of the HPO axis 
Explanation: When congenital GnRH deficiency is associated with anosmia or hyposmia (an absent or grossly impaired sense of smell), the disorder is known as Kallmann&;s syndrome. Two genetic mutations associated with Kallman&;s Syndrome : KAL gene - X - linked inheritance (Xp22.3) encoding anosmin - 1. Gene encoding FGFR1 (Fibroblast growth factor - 1 receptor) - autosomal dominant form. Anosmin - 1 is a neural adhesion molecule that promotes migration of GnRH neurons and olfactory neurons, from the olfactory placode into the hypothalamus during embryonic development. REF : Shaw book of gynecology 9th Ed.