This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplasia, Subject name: Radiology
Which of the following features on mammogram would suggest malignancy? 
Select and explain. 
A. Well defined lesion, B. A mass of decreased density, C. Areas of spiculated microcalcifications, D. Smooth borders
C: Areas of spiculated microcalcifications
Answer: C: Areas of spiculated microcalcifications 
Explanation: Ans. is 'c' i.e. Areas of spiculated microcalcifications Distinguishing features between benign and malignant lesions on mammogram:- BenignMalignantOpacitySmooth marginIII defined margin, Irregular stellate, spiculated margin, comet tail Low densityHigh density HomogeneousIn homogeneous Thin halowide haloCalcificationMacrocalcification (> 5mm inMicrocalcification (< 5 mm in diameter)diameter)Breast ParenchymaNormalArchitectural distortionNipple/areola+- Retracted+- RetractedSkinNormalthickenedCooper ligamentsNormalthickened, increase numberDuctsNormalfocal dilatationSubcutaneous retro mammary spaceNormalobliterated