This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mendelian Disorders: Single-Gene Defects, Subject name: Pathology
Mutations in COL 4A5 gene manifests as - 
Select and explain. 
A. Alport's syndrome, B. HNPCC, C. Good pasture, D. Vitiligo
A: Alport's syndrome
Answer: A: Alport's syndrome 
Explanation: Ans. is 'a' i.e., Alport's syndrome o Manifestations of Alport's syndrome are due to abnormal a} (COL4A3), OC4 (COL4A4), or a. (COL4A5).o This is due to mutations of:i) COL4 A5 in classic X-linked formii) COL4A3 or COL4A4 in autosomal forms.