This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: vitamins, Subject name: Biochemistry
Decarboxylation reactions require 
Select and explain. 
A. Riboflavin, B. Thiamine, C. Niacin, D. Biotin
B: Thiamine
Answer: B: Thiamine 
Explanation: Pyruvate dehydrogenase: The co-enzyme form is thiamine pyrophosphate (TPP). It is used in oxidative decarboxylation of alpha-keto acids, e.g. pyruvate dehydrogenase catalyzes the breakdown of pyruvate, to acetyl CoA and carbon dioxide (see Fig. 9.22).Alpha-ketoglutarate dehydrogenase: an analogous biochemical reaction that requires TPP is the oxidative decarboxylation of alpha-ketoglutarate to succinyl CoARef: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 478