This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
General paralysis of insane is associated with ? 
Select and explain. 
A. Neurosyphillis, B. Alzheimer's disease, C. Parkinson's disease, D. None of the above
A: Neurosyphillis
Answer: A: Neurosyphillis 
Explanation: Ans, A. NeurosyphillisGeneral paresis, also known as general paralysis ofthe insane or paralytic dementia, is a severe neuropsychiatric disorder, classified as an organic mental disorder and caused by the chronic meningoencephalitis that leads to cerebral atrophy in late-stagesyphilis.Degenerative changes are associated primarily with the frontal and temporal lobar coex-General paralysis of the Insane (GPI) is progressive deterioration of the whole mental and physical personality.Symptoms included exaggeratedkneejerk, Iack ofreaction ofthe pupils to light, an inabilityto pay attention, a'clouding'of consciousness, poor sho-term memory, tremulous voice, reflex disturbances, and retinal anomalies' and diminished skin sensation.Patients were often recognizable by their striking 'delusions of grandeur"