This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
All are useful in management of severe clostridium difficle-infection, except 
Select and explain. 
A. Vancomycin oral, B. Neomycin enema, C. IV metronidazole, D. Tigecycline
B: Neomycin enema
Answer: B: Neomycin enema 
Explanation: Answer- B. Neomycin enemaOral voncomycin plus intravenous metronidazole is the treatment of choice for patients with severe und complicated clostrdium dilificle infection (CDI)