This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Antihelminthic which acts by flaccid paralysis of worms is- 
Select and explain. 
A. Piperazine, B. Bephenium, C. Pyrantel, D. None
A: Piperazine
Answer: A: Piperazine 
Explanation: Ans. is 'a' i.e., Piperazine Piperazine o It causes hyperpolarization of ascaris muscle by a GABA agonistic action opening Cl-channels --> flaccid paralysis. o Piperazine safe and well tolerated drug, it is also safe in pregnancy. Remember o Drugs causing flaccid paralysis Ivermectin, piperazine. o Drugs causing spastic paralysis --> Pyrantel pamoate, levamisole.