This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
T cell recognizes which antigen in graft rejection 
Select and explain. 
A. MHC II, B. MHC I, C. Both MHC I and MHC II, D. ABO antigen only
C: Both MHC I and MHC II
Answer: C: Both MHC I and MHC II 
Explanation: Both MHC I & II are recognizedThe major antigenic differences between a donor and recipient that result in rejection of transplants are differences in HLA allelesDendritic cells carried in the donor organs are the most impoant APCs for initiating the antigraft response, because they not only express high levels of class I and II MHC molecules but also are endowed with costimulatory molecules (e.g., B7-1 and B7-2). Ref: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Page no: 230