This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Malaria Drugs, Subject name: Pharmacology
Loading dose is given for which of the following drug 
Select and explain. 
A. Diazepam, B. Propranolol, C. Chloroquine, D. Aspirin
C: Chloroquine
Answer: C: Chloroquine 
Explanation: Chloroquine is a drug having maximum Volume of Distribution (Vd >1300 L). This means it is mostly distributed in the tissues whereas the main site of its pharmacological action is RBCs. Therefore, it is given as a loading dose to attain steady state plasma concentration quickly. Chloroquine is a synthetic 4-aminoquinoline that has been the mainstay of antimalarial therapy, is the drug of choice in the treatment of erythrocytic P. falciparum malaria, except in resistant strains.