This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
The cause of hyperuricemia and gout in glucose-6phosphatase deficiency is : 
Select and explain. 
A. More formation of pentose, B. Decreased availability of glucose to tissues, C. Increased accumulation of sorbitol, D. Impaired degradation of free radicals
A: More formation of pentose
Answer: A: More formation of pentose 
Explanation: A i.e More formation of pentose Von Gierke's (type Ia glycogen storage) disease d/t deficiency of glucose 6 phosphatase enzymeQ is autosomal recessive in inheritance. It is characterized by - Cells (of liver, renal tubular epithelium & intestinal mucosa) containing normal structured metabolically unavailable glycogen, hepato-renomegalyQ, doll like face, hypoglycemia, hyper-lipoemia, hyper cholesterolemia, fatty infiltration of liver, ketosisQ, acidemia, T lactic acid, t uric acid and stunted growth.