This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
All of the following statements about Creutzfcldt-Jakob disease are true, EXCEPT 
Select and explain. 
A. It is a neurodegenerative disease, B. It is caused by infectious proteins, C. Myoclonus is rarely seen, D. Brain biopsy is specific for diagnosis
C: Myoclonus is rarely seen
Answer: C: Myoclonus is rarely seen 
Explanation: (C) Myoclonus is rarely seen # Creutzfeldt-Jakob disease is a neurodegenerative disease caused by Prions> Myoclonus is seen in 90% of patients with Creutzfeldt - Jakob disease.> Prions are infectious proteinaceous material devoid of detectable amount of nucleic acids.> Characteristics of diseases caused by Prions - Diseases are confined to central nervous system Basic pathology is - Neurodegeneration - Spongiform encephalopathy> Presence of Amyloid plaques in brain Hosts shows no inflammatory response (Disease is almost always fatal)> Clinical features (Symptoms): Usually presents in middle ages Rapidly progressive dementia Myoclonic fasciculations (seen in 90%) Ataxia Somnolence> Characteristic EEC pattern - Paroxysms with high voltage and slow waves