This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pathology of Conception, Subject name: Gynaecology & Obstetrics
Congenital anamolies are most severe in 
Select and explain. 
A. Rubella infection, B. Mumps, C. CMV, D. Toxoplasma
A: Rubella infection
Answer: A: Rubella infection 
Explanation: Ans. is 'a' Rubella infectionRubella causes numerous serious defects in the fetus, but nowhere is it specifically written that it causes most severe congenital deformities. Just have a look at the various defects caused by Rubella and you won't need any further confirmation for the answer.Various fetal defects caused d/t RubellaCardiac malformations* PDA (most common)* VSD, PS, (Coarctation of Aorta is not present)*Deafness*Cataract*Glaucoma*Retinopathy*Microcephaly*Cerebral palsy*1UGRHepatosplenomegalyMental & Motor retardationThese defects occuring singly or in combination are known as "Congenital Rubella Syndrome"