This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Osteoporosis, Sex Hormones and OCPs, Subject name: Pharmacology
Tamoxifen increases the risk of which malignancy? 
Select and explain. 
A. Cervix, B. Vagina, C. Endometrium, D. Vulval
C: Endometrium
Answer: C: Endometrium 
Explanation: TAMOXIFEN Tamoxifen is a SERM that possess estrogen antagonistic activity in the breast and blood whereas agonistic activity in bone, uterus and liver. Its major indication is the treatment of breast carcinoma. It has beneficial effect on bone and lipid profile Tamoxifen can increase the risk of endometrial carcinoma and thromboembolism.