This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
Beta-lactamase production is a mechanism of resistance common to strains of H. influenzae, M. catarrhalis, and Neisseria gonorrhoeae. Which one of the following drugs is most likely to be effective against ALL strains of the above organisms? 
Select and explain. 
A. Amoxicillin, B. Ceftriaxone, C. Clindamycin, D. TMP-SMX
B: Ceftriaxone
Answer: B: Ceftriaxone 
Explanation: Ceftriaxone (IM) is a drug of choice in gonorrhea and is also highly effective in otitis media, infections in which beta-lactamase-producing strains of H. influenzae and M. catarrhalis are commonly implicated. The fourth-generation drug, cefepime, also has activity against these organisms. Amoxicillin and ticarcillin are susceptible to beta-lactamases. TMP-SMX does not cover all strains of the organisms listed, and the activity of clindamycin is restricted to gram-positive cocci and anaerobes.