This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
If cellular proteins do not fold into a specific conformation, their function are affected. Ceain disorders arise, if specific proteins are misfolded. Which of the following disorders arises due to conformational isomerization: 
Select and explain. 
A. Familial fatal insomnia, B. Hepatitis delta, C. Pernicious anemia, D. Lesch-Nyhan syndrome
A: Familial fatal insomnia
Answer: A: Familial fatal insomnia 
Explanation: A i.e Familial fatal insomnia