This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical, surgical and gynaecological illness complicating pregnancy, Subject name: Gynaecology & Obstetrics
Following antibiotics are safe to pregnancy: 
Select and explain. 
A. Aminoglycosides, B. Penicillin, C. Cotrimoxazole, D. Ciprofloxacin
B: Penicillin
Answer: B: Penicillin 
Explanation: Penicillin and its derivatives has a wide margin of safety and are not toxicto mother or fetus streptomycin:cause ototoxicity Tetracyclines including doxycline can cause staining of teeth and potentially skeletal abnormalities Quinolones like ciprofloxacin and norfloxacin are best avoided as they are toxic to developing cailage first trimester cotrimoxazole has been associated with bih defects especially cardiovascular TEXTBOOK OF OBSTETRICS, SHEILA BALAKRISHNAN,Pg no:569,2nd edition