This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diuretic, Subject name: Pharmacology
Severe hyperkalemia is seen in combination with: 
Select and explain. 
A. Amiloride and Furosemide, B. Lisinopril and furosemide, C. Losartan and amiloride, D. Propranolol and verapamil
C: Losartan and amiloride
Answer: C: Losartan and amiloride 
Explanation: Ans. C. Losartan and amilorideACE inhibitors/ARBs result in hyperkalemia.Side effectsa. Hypotension may occur especially in patients who are hypovolemic as a result of diuretics, salt restriction, or gastrointestinal fluid loss.b. Hyperkalemia- mostly in patients with renal impairment, NSAIDs & K+ sparing diuretics.c. Cough is due to increased levels of bradykinin (ACE inhibitors)d. Dysgeusiae. Angioedema, Rashes, Urticariaf. Foetopathic effect- in utero development of the kidneys is angiotensin dependent.g. ACEI's or ARBs, are contraindicated given during the second or third trimesters