This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
What is/are effect on the membrane when extracellular concentration of K+ decreased? 
Select and explain. 
A. | magnitude of RMP, B. | negativity of the membrane, C. | magnitude of RMP, D. | negativity of membrane
B: | negativity of the membrane
Answer: B: | negativity of the membrane 
Explanation: While K+ is positively charged and more abundant on the inside, there exists a great amount of negatively charged paicles (the anions), accounting for the negative charge inside the membrane. The cell membraneforms the border of a neuron and acts to control the movement of substances into and out of the cell. Ref guyton and hall textbook of medical physiology 12/e pg 58