This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anatomy of Skin, Subject name: Skin
Which of the following layers of epidermis is known as "prickle layer"? 
Select and explain. 
A. Stratum basale, B. Stratum spinosum, C. Stratum granulosum, D. Stratum corneum
B: Stratum spinosum
Answer: B: Stratum spinosum 
Explanation: Ans. B. Stratum spinosumStratum spinosum is also called as the prickle cell layer.* Stratum spinosum consists of intercellular attachments, also called desmosomes.* These desmosomes appear like spines on microscopy; hence, it is called as the prickle layer.* Their spiny (Latin, spinosum) appearance is due to the shrinking of the microfilaments between desmosomes that occurs when stained with H&E.