This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Parathyroid and adrenal glands, Subject name: Surgery
True about adrenocoical carcinoma: 
Select and explain. 
A. Rare tumor, B. More than half are functional, C. Most commonly associated with Cushing syndrome, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: ADRENOCOICAL CARCINOMARare tumor>50% are functional.Cushing's syndrome is most commonly seen, followed by virilization.Capsular or vascular invasion is the most reliable sign of cancer.