This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Penicillin & Cephalosporin, Subject name: Pharmacology
A 70 - year- old man was administered penicilline intravenously. Within 5 minutes, he developed genralised urticaria, swelling of lips, hypotension and bronchospasm. The first choice of treatment is to administer: 
Select and explain. 
A. chlorphenitramine inj., B. Epinephrine inj., C. High dose hydrocortisone tablet, D. nebulised salbutamol
B: Epinephrine inj.
Answer: B: Epinephrine inj. 
Explanation: Ans. is 'b' i.e. epinephrine injection Urticaria, swelling of lips, hypotension and bronchospasm within 5 minutes of i.v penicillin suggests anaphylactic reaction. It's a major problem with the use of penicillin.The t/t of choice for anaphylaxis is i.v epinephrine.