This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Type I hypersensitivity is mediated by which of the following immunoglobulins ? 
Select and explain. 
A. Ig A, B. Ig G, C. Ig M, D. Ig E
D: Ig E
Answer: D: Ig E 
Explanation: Harshmohan textbook of pathology 7th edition. *type 1 or anaphylactic or atopic reaction mediated by humoral antibodies of IgE type or reagin antibodies in response to antigen.