This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Pediatrics
Which of the following syndromes is best associated with congenital hea disease 
Select and explain. 
A. Lesch-Nyhan syndrome, B. Rasumussen syndrome, C. Holt oram syndrome, D. LEOPARD syndrome
C: Holt oram syndrome
Answer: C: Holt oram syndrome 
Explanation: Holt oram charge association syndrome is a autosomal dominant disease characterized by Cardiac lesion( ostium secundum ASD,VSD,TOF, pulmonary stenosis), coloboma, choanal atresia,genital hypoplasia,ear abnormalities,growth retardation due to TBX5 mutation Lesch nyhan syndrome/ juvenile gout is associated with self mutilation of hand & feet,intelluctal disability,early death Rasmussen syndrome is chronic focal encephalitis character used by seizure,hemiparesis,aphasia,dementia Leopard / noon an syndrome ,there will be Lentigines,Electrocardiographic conduction anomaly,Ocular hypeelorism, Pulmonary stenosis,Abnormal genitalia,Retarded growth & Deafness Ref : Ghai essential of pediatrics, eighth edition, p.no:401