This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gastrointestinal tract, Subject name: Pediatrics
Tropical Splenomegaly is characterized by all the following, except ________ 
Select and explain. 
A. Persistent high grade fever, B. Moderate to massive splenomegaly, C. Residence in areas endemic for Malaria, D. Clinical response to antimalarials
A: Persistent high grade fever
Answer: A: Persistent high grade fever 
Explanation: Tropical splenomegaly "Big spleen disease"found in adults in ceain hyper endemic malarial areas has been shown to be related to an abnormal immune response to plasmodial antigen features hepatomegaly anemia leucopenia massive splenomegaly increased serum IgM concentrations. continuous malaria chemoprophylaxis over many months cause a gradual reduction in the spleen size and clinical improvement Ref : PARASITOLOGY, K.D.CHATTERJEE,13 TH edition, Pg no:117