This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Following statement is true for hemophilia patients? 
Select and explain. 
A. All Females are carriers and all males are affected, B. All Males are carriers and all females are affected, C. Females are mostly carriers and all males are affected, D. Males are mostly carriers and all females are affected
C: Females are mostly carriers and all males are affected
Answer: C: Females are mostly carriers and all males are affected 
Explanation: Ans. is 'c' i.e., Females are mostly carriers and all males are affected Hemophilia is an X-linked recessive hemorrhagic disease due to mutations in the F8 gene (hemophilia A or classic hemophilia) or F9 gene (hemophilia B). The disease affects I in 10,000 males worldwide, in all ethnic groups; hemophilia A represents 80% of all cases. Male subjects are clinically affected; women, who carry a single mutated gene, are generally asymptomatic. Family history of the disease is absent in 30% of cases and in these cases, 80% of the mothers are carriers of the de novo mutated allele.