This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Osteoporosis, Sex Hormones and OCPs, Subject name: Pharmacology
The unique propey of SERMs is that they: 
Select and explain. 
A. Have both estrogenic and progestational agonistic activity, B. Inhibits the aromatase enzyme that is required for estrogen synthesis, C. Produces estrogenic effect without binding to estrogen receptors, D. Act as agonist in some tissues and antagonist in other tissues
D: Act as agonist in some tissues and antagonist in other tissues
Answer: D: Act as agonist in some tissues and antagonist in other tissues 
Explanation: SERM: 1. Raloxifene- Agonist at bone - Agonist in blood : Increase HDL level- Antagonist at breast: Decrease breast carcinoma risk- Antagonist at endometrium: Decrease endometrium carcinoma- Agonist at liver: Increase thromboembolism risk 2. Tamoxifen- Agonist at bone - Agonist in blood : Increase HDL level- Antagonist at breast: Decrease breast carcinoma risk- Agonist at endometrium: Increase endometrium carcinoma- Agonist at liver: Increase thromboembolism risk Tamoxifen, Doloxifen and toremifene are beneficial on: - Bone - Blood - Breast 3. Clomifene Antagonist at pituataryHypothalamus - GnRHPituatary - LH/FSHOvary - E/P