This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: fungal infection, Subject name: Medicine
True about Cryptococcus neoformans is A/E: 
Select and explain. 
A. Capsule excludes India ink paicles, B. Common in immunocompromised patient, C. Anti-capsular antibody prevents recurrence, D. Strongly positive Mucicarmine stain of the organism in tissue is useful
C: Anti-capsular antibody prevents recurrence
Answer: C: Anti-capsular antibody prevents recurrence 
Explanation: Cryptococcal gelatinous capsule stains bright pink with mucicarmine stain and discriminates the organism from histoplasma and blastomycosis. India ink stain paicles are extruded by the gelatinous capsule and hence only the background is stained. In cryptococcal meningitis, CSF examination reveals evidence of chronic meningitis with mononuclear cell pleocytosis and increased protein levels. Cryptococcal antigen (CRAg) detection in CSF and blood is based on serologic detection of cryptococcal polysaccharide and is both sensitive and specific. Cryptococcus neoformans :Common in immunocompromised patient