This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Even in large dosages used in malaria, quinine does not cause toxicity, because - 
Select and explain. 
A. It enters in fat cells, B. Elevated plasma alpha acid glycoprotein, C. Deposited in infected RBC's, D. Excreted rapidly in urine
B: Elevated plasma alpha acid glycoprotein
Answer: B: Elevated plasma alpha acid glycoprotein 
Explanation: Ans. is 'b' i.e., Elevated plasma alphai acid glycoprotein o Patient with malaria can achieve high plasma level of quinine with few signs of toxicity because of the elevated plasma alphal acid glvcoproteins, produced during acute phase of infection. It prevents quinine toxicity through binding of most of the drug in the plasma.