This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Which of the following syndromes is best associated with congenital heart disease – 
Select and explain. 
A. Lesch–Nyhan syndrome, B. Rasumussen syndrome, C. Holt Oram syndrome, D. LEOPARD syndrome
C: Holt Oram syndrome
Answer: C: Holt Oram syndrome 
Explanation: "The strongest familial tendency is known in ASD associated with bony abnormalities (Holt-oram syndrome)"
Genetics of Congenital heart disease