This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
A child is brought to you with history of mental retardation. On examination you find that he also has dolichocephaly, low set ears, micrognathia, clenched hands with overlapping fingers, simian crease and rocker bottom feet. Which is the commonest cardiac lesion you would expect to find in this patient? 
Select and explain. 
A. ASD, B. VSD, C. PDA, D. Pulmonary stenosis
B: VSD
Answer: B: VSD 
Explanation: This is a case of Edward's syndrome (Trisomy 18). The commonest cardiac lesion in this condition is VSD followed by PDA and ASD. Multiple valvular regurgitant lesions may also be seen in Edward's syndrome. Ref: Pediatric Clinical Methods by Meharban Singh, 3rd Edition, Page 176