This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
Which of the following drugs can produce dramatic improvement in patients with Type II lepra reaction? 
Select and explain. 
A. Thalidomide, B. Steroids, C. Dapsone, D. Clofazamine
A: Thalidomide
Answer: A: Thalidomide 
Explanation: Ans. a (Thalidomide). (Ref. Harrison, Internal Medicine, 15th ed., 1038)Treatment of Type I Lepra reactionTreatment of Type II Lepra reaction# Best with corticosteroids.# Thalidomide ineffective in Typel reaction and clofazimine questionable.# In mild reaction give antipyretics# Then glucocorticoids# Thalidomide causes dramatic improvement probably attributable to its reduction of TNF levels and IgM synthesis and slowing of PMN migration.