This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
A 40-year-old male complains of weakness, weight loss, and abdominal pain. On examination, the patient has diffuse hyperpigmentation and a palpable liver edge. Polyahritis of the wrist and hips is also noted. FBS is 185 mg/dl. The most likely diagnosis is? 
Select and explain. 
A. Type I DM, B. Pancreatic carcinoma, C. Addison's disease, D. Hemochromatosis
D: Hemochromatosis
Answer: D: Hemochromatosis 
Explanation: Hemochromatosis Hemochromatosis is a disorder of iron storage that results in deposition of iron in parenchymal cells. The liver isusually enlarged, and excessive skin pigmentation is present in 90% of symptomatic patients at the time of diagnosis. Diabetes occurs secondary to direct damage of the pancreas by iron deposition. Ahropathy develops in 25 to 50% of cases. Other diagnoses listed could not explain all the manifestations of this patient's disease process. Addison's disease can cause weight loss and hyperpigmentation but does not affect the liver or joints; it is associated with hypoglycemia rather than diabetes mellitus.