This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Peripheral Nerve Injuries, Subject name: Orthopaedics
Earliest sign of compartment syndrome of leg is: 
Select and explain. 
A. Skin mottling, B. Loss of pulse, C. Tingling numbness, D. Pain on passive stretching of toes
D: Pain on passive stretching of toes
Answer: D: Pain on passive stretching of toes 
Explanation: Ans. D. Pain on passive stretching of toesPain out of proportion to clinical situation is usually the first symptom in compartment syndrome of leg while pain on passive stretching is most sensitive sign prior to the onset of ischemia. This is the most frequent in the lower leg.