This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
True about apoptosis 
Select and explain. 
A. Increase in lysosomal enzyme, B. Increase in caspases, C. Phosphatidyl serine has impoant role, D. Intemucleosomal cleavage of nucleus
B: Increase in caspases
Answer: B: Increase in caspases 
Explanation: Apoptotic DNA fragmentation is a key feature of apoptosis, a type of programmed cell death. Apoptosis is characterized by the activation of endogenous endonucleases, paicularly the caspase-3 activated DNase (CAD), with subsequent cleavage of nuclear DNA into internucleosomalfragments of roughly 180 base pairs (bp) and multiples thereof (360, 540 etc.). The apoptotic DNA fragmentation is being used as a marker of apoptosis and for identification of apoptotic cells Ref guyton and hall textbook of medical physiology 12/e pg 40 and robbins 9/e pg 18