This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Most common cause of hereditary spherocytosis? 
Select and explain. 
A. Actin, B. Glycophorin, C. Spectrin-Ankyrin complex, D. Band 4
C: Spectrin-Ankyrin complex
Answer: C: Spectrin-Ankyrin complex 
Explanation: About 60% of HS cases results from a defect in the ankyrin-spectrin complex , with genes for a or b subunits of spectrin dimer (SPTA1 ,SPTB) or for ankyrin (ANK1)being implicated in diff genetic type. 25% ~> involve deficiency in band 3, the anion channel. Ref:Postgraduate Hematology by Victor Hoffbrand ,pg:131 Ref Robbins 9/e pg 412