This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
Sterility is caused by: 
Select and explain. 
A. Vinca alkaloids, B. Alkylating agents, C. Antimetabolites, D. Actinomycin D
B: Alkylating agents
Answer: B: Alkylating agents 
Explanation: Sterility and secondary leukemias are distinctive adverse effects of alkylating agents. Other adverse effects of alkylating agents: BM depression Alopecia Mucositis - Diarrhoea Hyperuricemia