This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Microbiology
Otitis and osteomyelitis is seen in 
Select and explain. 
A. Hepatitis B vaccine, B. BCG, C. Measles vaccine, D. IPV
B: BCG
Answer: B: BCG 
Explanation: The most serious complication of BCG vaccination is disseminated BCG infection.The most frequent disseminated infection is BCG osteomyelitis (0.01-43 cases per million doses of vaccine administered) which usually occurs 4 months to 2 years after vaccination.Fatal disseminated BCG infection has occurred at a rate of 0.06-1.56 cases per million doses; these deaths occurred primarily among immunocompromised persons.BCG otitis - A form of acute otitis media occasionally observed in infants after oral administration of BCG tuberculosis vaccine.In pus and granulation of the ear in a number of patients detected acid-bacteria vaccine strain BCG. Typically imperceptible onset at normal temperature, the growth of granulation tissue, for lingering, long-term, but beneficial.