This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vasculitis, Subject name: Pathology
Most common organs involved in Wegener's granulomatosis are: 
Select and explain. 
A. Skin and nose, B. Lung and kidney, C. Hea and kidney, D. Kidney and nervous system
B: Lung and kidney
Answer: B: Lung and kidney 
Explanation: * Wegener granulomatosis also known as Granulomatosis with polyangiitis * The most common organs involved in Wegener's are lungs and kidneys. * PR3-ANCAs are also present in maximum cases. * PR3 ANCAs are useful markers of disease activity * Histological features : -Upper respiratory tract : lesions shows granulomas with central necrosis and accompanying vasculitis. -Kidney : Focal necrotizing and often crescentic glomerulonephritis.