This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Uterine fibroid, Subject name: Gynaecology & Obstetrics
The drug which reduces the size of myoma include- 
Select and explain. 
A. GnRH agonist, B. Danazol, C. Progesterone, D. Mifepristone
A: GnRH agonist
Answer: A: GnRH agonist 
Explanation: GnRH analogues used for 6months reduces the tumour size by 50-80%. This treatment in premenopausal women, young women and infeility caused by cornual fibroid eliminates the need for surgery. RU 486(Mifepristone) 10-25mg daily for 3months causes amenorrhoea and shrinkage of tumour by 50%. Danazol 400-800mg daily for 3-6months reduces the size of the tumour. However side effects includes hirsutism as well as costly. Reference: Textbook of shaw,15th edition,page 359