This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
Most common heart lesion in down syndrome: 
Select and explain. 
A. Endocardial cushion defect, B. ASD with ostium secundum, C. VSD, D. Coarctation of aorta
A: Endocardial cushion defect
Answer: A: Endocardial cushion defect 
Explanation: a. Endocardial cushion defect(Ref: Nelson's 20/e p 610-614)Most common cardiac defect in Down syndrome is Endocardial cushion defect or Atrioventricular septal defect