This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Gender specific adverse effect of valproate is 
Select and explain. 
A. Weight gain, B. Tremors, C. Alopecia, D. Polycystic ovarian disease
D: Polycystic ovarian disease
Answer: D: Polycystic ovarian disease 
Explanation: Long term use of valproate in young girl is associated with higher incidence of polycystic ovarian disease and menstrual irregularities. REf KD Tripathi 8th ed.