This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All are TNF-alpha antagonists used in rheumatoid arthritis except: 
Select and explain. 
A. Ifosfamide, B. Infliximab, C. Etanercept, D. Adalimumab
A: Ifosfamide
Answer: A: Ifosfamide 
Explanation: SOME IMPORTANTLY USED TNF - ALPHA INHIBITORS ARE AS FOLLOWS:

Etanercept : Chimeric protein and neutralizes both TNF alpha and TNF beta can be used along with methotrexate in rheumatoid arthritis also used in ankylosing spondylosis, juvenile arthritis and plaque psoriasis.
Infliximab : Monoclonal antibody against TNF alpha.used in refractory rheumatoid arthritis, fistulating Crohn's disease, ulcerative colitis and psoriasis.
Adalimumab : Fully human recombinant antibody anti TNF alpha. It is less antigenic.use same as infliximab.