This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Analgesic action of paracetamol is due to which receptors 
Select and explain. 
A. NKl, B. BKI, C. TRPV-1, D. C2x3
C: TRPV-1
Answer: C: TRPV-1 
Explanation: Ans: C. TRPV-1(Ref: Oxford textbook of Palliative care for children p. 712)Paracetamol was shown to be conveed in the brain and spinal cord through a precess of deacetylation followed by conjugation with arachidonic acid to form N-arachidonoylphenolamine (AM404).AM404 is a known endogenous cannabinoid.Functions both as a potent actiyator of vanilloid subtype 1 receptors (TWV-1).Inhibitor of cellular anandamide uptake.Increases other endogenous cannabinoids levels acting directly on cannabinoid-1 receptors (CBI).TRPVI and CBI receptors are present in pain and thermoregulatory pathways, giving paracetamol its analgesic and antipyretic actions.