This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is the most common mutation in Ewing's sarcoma - 
Select and explain. 
A. Translocation X : 18, B. Translocation 11; 22, C. Activative mutation of G5alpha surface protein, D. Missense mutation in EXTI
B: Translocation 11; 22
Answer: B: Translocation 11; 22 
Explanation: Ewing's sarcoma is typically characterized by a translocation t (11; 22) (q 24; q12) in up to 90% of patients.