This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
True statements regarding Aspirin toxicity is 
Select and explain. 
A. Tinnitus is an early symptom, B. Hypehermia, tachypnea are Early complications, C. cos thrombocytopenic purpura, D. Children can tolerate much higher dose than adult
A: Tinnitus is an early symptom
Answer: A: Tinnitus is an early symptom 
Explanation: Symptoms of Aspirin poisoning At anti inflammatory dose (3-6grams per day) produces the syndrome called salicylism comprising of dizziness, tinnitus, Veigo, excitement, mental confusion, reversible impairment of hearing The dose has to be titrated to one which is just below that produces the symptom,8 tinnitus is a good guide Metabolic acidosis ,hypehermia and acidotic breathing are seen in severe poisoning Aspirin causes platelet dysfunction by inhibiting cyclooxygenase pathway fatal dose in adult is 15 to 30 grams but considerablely lower in children Refer kDT 6/e p189