This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Biochemistry
'I' cells disease is due to defect in:- 
Select and explain. 
A. Peroxisome, B. Mitochondria, C. Lysosome, D. Golgi apparatus
D: Golgi apparatus
Answer: D: Golgi apparatus 
Explanation: I cell disease (Inclusion cell disease) Pa of the lysosomal storage disease family Defective phosphotransferase (uridine-diphosphate-N-acetylglucosamine 1-phosphotransferase) an enzyme of the Golgi apparatus Enzyme that phosphorylates mannose residues of glycoproteins to allow their delivery to lysosomes from Golgi Apparatus =Features:- Protein targeting disorder Resembles Hurler syndrome Neurological deterioration mucopolysacchariduria is not present,It is not a mucopolysaccharidosis, it is mucolipidosis - glycolipids are accumulated Marked intracellular deficiency of a number of lysosomal hydrolases and elevation of these enzymes in plasma.