This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nephropathy, Subject name: Pediatrics
Mutation in NPHS 1 gene causes which disease? 
Select and explain. 
A. Alport syndrome, B. Congenital Finnish type nephrotic syndrome, C. Focal segmental glomerulonephritis, D. Nail patella syndrome
B: Congenital Finnish type nephrotic syndrome
Answer: B: Congenital Finnish type nephrotic syndrome 
Explanation: Ans. (b) Congenital Finnish type nephrotic syndromeRef: Nelson 18th ed./ Table 527.1* CNF is one of the Finnish heritage diseases and rare form of nephrotic syndrome.* It occurs predominantly in families of Finnish origin and manifests shortly after birth* The condition is caused by a defect in the protein nephrin, which is found in the kidney.* Gene responsible is NPHSL.