This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In hashimoto's disease serum antibodies are mainly against -a)  Thyroid folliclesb)  Thyroxinec)  Thyroglobulinsd)  Iodine 
Select and explain. 
A. a, B. bc, C. ac, D. b
C: ac
Answer: C: ac 
Explanation: Hashimotos Thyroiditis -

Hashimoto's thyroiditis is an autoimmune disorder
It is the most common cause of primary hypothyroidism
It mainly affects middle aged females
Although it is primarily a disease of the middle aged females, it can occur in children and is a major cause of nonendemic goitre in children.
Pathogenesis -
Hashimoto's thyroiditis is an autoimmune disorder characterized by the presence of following IgG antibodies -


Antithyro globulin antibody   
Antimicrosomal antibody 
Antibody directed against a component of colloid
Antibody against TSH receptors


These antibodies do not correlate with severity of disease.

They have a diagnostic value