This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Hyperscretory granules seen in with lungCa 
Select and explain. 
A. Adeno Ca, B. Small cell Ca, C. Large cell Ca, D. Bronchoalveolar Ca
B: Small cell Ca
Answer: B: Small cell Ca 
Explanation: Small cell carcinoma: Small cell carcinomas are frequently hilar or central in location, have strong
relationship to cigarette smoking and are highly malignant tumours. They are most often associated with ectopic
hormone production because of the presence of neurosecretory granules in majority of tumour cells which
are similar to those found in argentaffin or Kulchitsky cells normally found in bronchial epithelium. By immunohistochemistry,
these tumour cells are positive for neuroendocrine markers: chromogranin, neuron-specific enolase (NSE) and synaptophysin.