This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Schizophrenia, Subject name: Psychiatry
Most important receptors involved with schizophrenia are? 
Select and explain. 
A. GABAA, B. GABAB, C. D2, D. 5-HT1
C: D2
Answer: C: D2 
Explanation: Ans. is 'c' i.e., D2 * Dopamine hypothesis is the most accepted hypothesis for schizophrenia. There is hyperactivity of dopaminergic system. This hypothesis is supported by:i) Amphetamine and cocaine which release dopamine in central synapses induce schizophrenia like symptoms; andii) Antipsychotic drugs control the schizophrenic symptoms by blocking dopamine (D2) receptors.* Other neurotransmitters involved are: - Increased serotonin, Decreased GABA, variable change (Increased or decreased) glutamate, and increased norepinephrine.