This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
True about benzodiazepines - 
Select and explain. 
A. Increased release of GABA, B. Antagonzing release of GABA, C. Lorazepam is shoer acting than temazepam, D. Atropine is its antagonist
C: Lorazepam is shoer acting than temazepam
Answer: C: Lorazepam is shoer acting than temazepam 
Explanation: Ans. is 'c' i.e., Lorazepam is shoer acting than temazepam o Lorazepam has t1/2 10-20 hours, while Temazepam has t1/2 10-40 hours. About other options o BZDs do not increase or decrease the release of GABA, they bind on GABAA receptors and increase Cl- conductance --> GABA facilitatory action. o Flumazenil (not atropine) is the antagonist of BZDs.