This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Poor prognosis in AML is indicated by: 
Select and explain. 
A. Inversion 16, B. Translocation 15;17 (t15; 17), C. Normal cytogenecity, D. Monosomy 7
D: Monosomy 7
Answer: D: Monosomy 7 
Explanation: Monosomy 7 is associated with a very poor prognosis. Patients with t (8, 21), t (15: 17) and inv (16) have a good prognosis.