This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2019, Subject name: Surgery
Mechanism of action of teduglutide in sho bowel syndrome:- 
Select and explain. 
A. GLP-2 analogue, B. HT la inhibitor, C. GLP-1 analogs, D. C- peptic analogs
A: GLP-2 analogue
Answer: A: GLP-2 analogue 
Explanation: RCT's have shown that, teduglutide, a GLP-2 analogue (Glucagon like peptide -2) is resistant to degradation by the proteolytic enzyme dipeptidyl peptidase 4 and therefore has a longer half-life than GLP-2. It is well tolerated and has led to the restoration of intestinal functional and structural integrity through intestinotrophic and proabsorptive effects. Sho bowel syndrome: Caused by resection / bypass surgery of small intestine Causes severe diarrhoea and impaired nutrient absorption leading to severe malnutrition Usually appears if length of small intestine < 200 cms Medical management Anti-diarrhoeal agents Cholestyramine Vitamin supplements Mainstay treatment: Teduglutide (GLP -2 analogue)