This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All of the following antihistaminic agents lack anticholinergic property, except: 
Select and explain. 
A. Promethazine, B. Astemizole, C. Levo-cetrizine, D. Loratidine
A: Promethazine
Answer: A: Promethazine 
Explanation: All the drugs listed in the question are second generation anti-histaminic agents, except promethazine.
Anticholinergic action: Many H1 blockers in addition antagonize the muscarinic actions of Ach. The antimuscarinic action can be graded as: