This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemolytic anemia, Subject name: Pediatrics
A 6 years old child belonging to Punjabi family with past history of blood transfusions presented with hemoglobin-3.5 gm/dL, MCV-30 fL. Peripheral smear findings of microcytic hypochromic anemia with target cell and reduced osmotic fragility. The probable diagnosis of patient: 
Select and explain. 
A. Alpha thalassemia, B. Beta thalassemia, C. Sickle cell anemia, D. G6PD deficiency
B: Beta thalassemia
Answer: B: Beta thalassemia 
Explanation: - Peripheral smear findings of microcytic hypochromic anemia with target cell and reduced osmotic fragility with severe transfusion requiring anemia is suggestive of Beta thalassemia. OTHER OPTIONS: Alpha thalassemia - Doesn't present with severe anemia requiring transfusion Sickle cell anemia - features of sickle cell crisis like hand foot syndrome/ priapism etc are not mentioned in question G6PD deficiency - No history of oxidative stress is mentioned in the question.