This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inborn Errors of Metabolism, Subject name: Pediatrics
Wilson disease all are true except - 
Select and explain. 
A. AR, B. KF ring, C. Raised copper level, D. Raised ceruloplasmin level
D: Raised ceruloplasmin level
Answer: D: Raised ceruloplasmin level 
Explanation: Ans. is 'd' i.e., Raised ceruloplasmin level Wilson diseaseo Autosomal recessive.o Degenerative changes in brain, liver and KF ring in cornea (Descement membrane),o Defect in Copper metabolism (copper toxicosis).o Best screeing test is to measure serum ceruloplasmin,o Decrease ceruloplasmin in WDo Failure of copper to be incorporated into ceruloplasmin leads to plasma protein with shorter TlA which leads to decrease ceruloplasmin level.