This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Type 1 Dentinogenesis imperfecta is caused by mutation in: 
Select and explain. 
A. DMP-1 gene, B. BSP- 1 gene, C. DSPP gene, D. SPP1 gene
C: DSPP gene
Answer: C: DSPP gene 
Explanation: Type 1 Dentinogenesis imperfecta is caused by a mutation in the DSPP gene (gene map locus 4q21.3), encoding dentin phosphoprotein and dentin sialoprotein. While Type 2 is caused by DMP-1, BSP-1, SPP1 gene.
Ref: Shafer's textbook of oral pathology 7th edition page55