This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
Which of the following is not a second generation antihistamines 
Select and explain. 
A. Cyclizine, B. Fexofenadine, C. Loratidine, D. Acrivastine
A: Cyclizine
Answer: A: Cyclizine 
Explanation: Antihistamines are classified as first generation and second generation compounds on the basis of CNS penetration and anticholinergic propeies. first generation antihistamines can penetrate blood brain barrier and possess additional anticholinergic propeies which are lacking in second generation drugs. cyclizine is a first generation Where are citirizen ,loratidine and fexofenadine are second generation drugs Refer Goodman and Gilman 12/e p92