This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Regional Anesthesia, Subject name: Anaesthesia
Metabolism of amide local anesthetic is slowed in which of the following condition 
Select and explain. 
A. Liver cirrhosis, B. Acute renal failure, C. Pseudocholinesterase deficiency, D. Chronic renal failure
A: Liver cirrhosis
Answer: A: Liver cirrhosis 
Explanation: Decreasing systemic absorption of local anesthetics increase their safety margin in clinical uses. The rate and extent of systemic absorption depends on the site of injection, the dose, the drugs intrinsic Pharmacokinetic propeies and the addition and cytochrome P450 enzymes. Severe liver disease may slow the clearance of amino amide local anesthetics and significant drug levels may therefore accumulate.