This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
Anti-Saccharomyces cerevisiae antibodies ares seen in? 
Select and explain. 
A. Crohn's disease, B. Scleroderma, C. SLE, D. Sjogren's syndrome
A: Crohn's disease
Answer: A: Crohn's disease 
Explanation: Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations REFERANCE. nih.gov