This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Which of these is not a marker of active replicative phase of chronic hepatitis B? 
Select and explain. 
A. HBV DNA, B. HBV DNA polymerase, C. Anti-HBC, D. AST and ALT
C: Anti-HBC
Answer: C: Anti-HBC 
Explanation: Ans. (c) Anti-HBC Anti-HBC has no relation with viral replication HBV DNA, HBV DNA polymerase represent active viral replication Level of HBV DNA correlates well with the degree of liver injury as suggested by raised AST, ALT It is not compulsory in chronic active hepatitis that HBeAg is positive. Infact HBeAg negative chronic hepatitis B is more dangerous.