This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neuro-ophthalmology, Subject name: Ophthalmology
Leber's optic neuropathy, true is 
Select and explain. 
A. Typically presents in the fouh decade of life, B. Males do not transmit the disease, C. Is inherited in autosomal X-link fashion, D. The optic disc is pale early in the disease
B: Males do not transmit the disease
Answer: B: Males do not transmit the disease 
Explanation: It is a type of hereditary optic neuritis which primarily affects males around the age of 20 years. It is transmitted by the female carriers. The condition is characterised by progressive visual failure. The fundus is initially normal or in the acute stage disc may be mildly hyperaemic with telangiectatic microangiopathy. Eventually bilateral primary optic atrophy ensues. Ref: AK Khurana 4thE pg 296