This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Knudsen's two hit hypothesis is for 
Select and explain. 
A. Glaucoma, B. Retinoblastoma, C. Optic glioma, D. Meningioma
B: Retinoblastoma
Answer: B: Retinoblastoma 
Explanation: Knudson gave the hypothesis that there are two mutations needed for Retinoblastoma to manifest. Either both hits are on somatic cells or one is at the somatic cells and one is at germ cell. Respectively, it can be sporadic or a hereditary case Refer khurana 6/e p 303