This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which of the following markers in the blood is the most reliable indicator of recent hepatitis Binfection? 
Select and explain. 
A. HBsAg, B. IgG anti - HBs, C. IgM anti - HBc, D. IgM anti - Hbe
C: IgM anti - HBc
Answer: C: IgM anti - HBc 
Explanation: Answer is C (IgM anti-HBc): Hbs Ag is present in recent hepatitis B infection but it is not specific to acute infection (it may also be seen in carriers). IgM anti- HBc is specific for acute or recent hepatitis, and hence is the answer of choice.