This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
A baby is born prematurely at 28 weeks gestational age with a bihweight of 1200 g. Ventilation with high paial pressures of oxygen is staed, but the neonatologist is concerned about the possible development of retinopathy of prematurity (formerly called retrolental fibroplasia). What is the underlying mechanism by which this retinal lesion may develop? 
Select and explain. 
A. Ganglion cell degeneration, B. Inappropriate vascular proliferation, C. Optic nerve degeneration, D. Pigment deposition in retina
B: Inappropriate vascular proliferation
Answer: B: Inappropriate vascular proliferation 
Explanation: The underlying lesion in retinopathy of prematurity (retrolental fibroplasia) is an inappropriate proliferation of vessels in the inner layers of the retina. If the process is disrupted early, the retina may heal with little residual damage. However, persistence of the process predisposes for permanent damage due to exudation, hemorrhage, and secondary detachment of the retina. Ganglion cell and optic nerve degeneration are features of retinal damage due to glaucoma. Pigment deposition in the retina is unrelated to retinopathy of prematurity. Ref: Fletcher E.C., Chong N., Augsburger J.J., Correa Z.M. (2011). Chapter 10. Retina. In P. Riordan-Eva, E.T. Cunningham, Jr. (Eds), Vaughan & Asbury's General Ophthalmology, 18e.