This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
Which of the following circulating antibodies has the best sensitivity and sepcificity for the diagnosis of celiac disease - 
Select and explain. 
A. Anti-endomysial antibody, B. Anti-tissue transglutaminase antibody, C. Anti-gliadin antibody, D. Anti-reticulin antibody
A: Anti-endomysial antibody
Answer: A: Anti-endomysial antibody 
Explanation: IgA anti-endomysial antibodies are found in 90% coeliac patients. They are a very specific & sensitive marker for coeliac disease and dermatitis herpetiformis. The anti-endomysial antibody test has been suggested to be 98% sensitive and 98% specific for clinical or subclinical coeliac disease Ref Davidson edition23rd pg 805