This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Ulcer, Subject name: Pharmacology
Proton pump inhibitors are most effective when they are given: 
Select and explain. 
A. After meals, B. Shortly before meals, C. Along with H2 blockers, D. During prolonged fasting periods
B: Shortly before meals
Answer: B: Shortly before meals 
Explanation: Ans. (B) Shortly before meals(Ref: KDT 8th/e p700)Proton pump inhibitors are used just before meals. Food stimulates the secretion of gastric acid that will be reduced by PPIs if these are given just before meals.