This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
Pyrimidine overproduction results in all except 
Select and explain. 
A. Hyperuricemia, B. Reye syndrome, C. orotic aciduria, D. Megaloblastic anemia
A: Hyperuricemia
Answer: A: Hyperuricemia 
Explanation: Defective enzyme of pyrimidine metabolism Signs and symptoms Dihydropyrimidine dehydrogenase Can develop toxicity to 5-fluorouracil, also a substrate for this dehydrogenase Orotate phosphoribosyl transferase and orotidylic acid decarboxylase Orotic acid aciduria type 1, megaloblastic anemia Orotidylic acid decarboxylase Orotic acid aciduria type 2 Pyrimidine overproduction is not the causal factor in Reye's syndrome. Reye's syndrome results in secondary pyrimidine overproduction. Reference: Harpers illustrated biochemistry 30th edition