This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of protein and amino acid, Subject name: Biochemistry
UAC to UAG 
Select and explain. 
A. Nonsense mutation, B. Frameshift mutation, C. Deletion, D. Missense mutation
A: Nonsense mutation
Answer: A: Nonsense mutation 
Explanation: UAC, a tyrosine can be mutated to a termination codon, UAA or UAG. This leads to premature termination of the protein, and so functional activity may be destroyed. This process is called nonsense or terminator codon mutation. Frameshift mutation is due to addition or deletion of bases. Missense mutation is due to a change in amino acid may be produced in the protein. These are the effects of mutation, whereas deletion, substitution, inseion are classification of mutation.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 613