This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
Free water clearance is decreased by? 
Select and explain. 
A. Vincristine, B. Vinblastine, C. Chlorpropamide, D. Furosemide
D: Furosemide
Answer: D: Furosemide 
Explanation: Free water clearance is the volume of blood plasma that is cleared of solute-free water per unit time. Diuretics usually decrease free water clearance by excreting more solutes in the urine free water clearance of zero means the kidney is producing urine isosmotic with respect to the plasma. REF Essentials of Medical Pharmacology, K.D Tripathi,6 th edition, page 564