This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Radiology
Earliest radiological change to appear in case of acute osteomyelitis is 
Select and explain. 
A. Periosteal reaction, B. Loss of plane between soft tissue and muscle, C. Sequestrum formation, D. Bony sclerosis
B: Loss of plane between soft tissue and muscle
Answer: B: Loss of plane between soft tissue and muscle 
Explanation: Ans. Loss of plane between soft tissue and muscle