This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacotherapy in psychiatry, Subject name: Anatomy
which of the following is not true regarding tri cyclic antidepressent 
Select and explain. 
A. it is safe in bipolar depression as it does not cause switch to mania, B. it causes sedation, C. it causes weigh tgain, D. it causes giddiness
A: it is safe in bipolar depression as it does not cause switch to mania
Answer: A: it is safe in bipolar depression as it does not cause switch to mania 
Explanation: TCA * MECHANISM This is an antidepressant with three rings. It acts by blocking the transpoers of neurotransmitters resulting in increased neurotransmitters in synapse DRUGS AMITRYPTILLINE IMIPRAMINE CLOMIPRAMINE DESIPRAMINE NORIPTILLINE DOXEPINE * USE AMITRYPTILLINE========PAIN WITH DEPRESSION IMIPRAMINE==========CHILDHOOD ENEURESIS CLOMIPRAMINE========OCD * SIDE EFFECTS ANTI HISTAMINERGIC==== sedation, weight gain ANTI MUSCURANIC=======dryness of mouth ANTI ADRENERGIC========hypotension, giddiness SWITCH TO MANIA when used in BIPOLAR DEPRESSION Ref. kaplon and sadock, synopsis of psychiatry, 11 th edition, 955