This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All of the following drugs are useful in detrussor instability except - 
Select and explain. 
A. Solefenacin, B. Tolterodine, C. Flavoxate, D. Duloxetine
D: Duloxetine
Answer: D: Duloxetine 
Explanation: Ans. is 'd' i.e., Duloxetine Detrusor instability o Detrusor instability or unstable bladder is characterized by uninhibited, unstable contractions of the detrusor which may be of unknown etiology or secondary to an upper motor neuron lesion or bladder neck obstruction. Since detrusor contracts under parasympathetic influence, Anticholinergic (specifically antimuscarinic) drugs are used to treat overactive bladder disease or detrusor instability. o These agents lower intravesical pressure, increase capacity and reduce the frequency of contractions by antagonizing parasympathetic control of bladder. o These agents include : - Darifenacin, Solefenacin, Tolterodine, Trospium chloride, Oxybutynin, Solifenacin, Flavoxate