This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
True about atherosclerosis ? 
Select and explain. 
A. Chronic inflammatory disorder of vessel wall, B. Not lead to complications of vessel wall, C. Thoracic aoa more than abdominal aoa, D. Atherosclerostic plaques do not demonstrate neovascularization
A: Chronic inflammatory disorder of vessel wall
Answer: A: Chronic inflammatory disorder of vessel wall 
Explanation: Ans. is 'a' i.e., Chronic inflammatory disorder of vessel wall Facts about atherosclerosis Is a chronic inflammatory and healing response of the aerial wall to endothelial injury.Atherosclerosis progresses in the following sequence:Endothelial injury and dysfunction - Accumulation of lipoproteins (mainly LDL) Monocyte adhesion to the endothelium, followed by migration into the intima and transformation into macrophages and foam cells - Platelet adhesion factor release from activated platelets, macrophages, and vascular wall cells - Smooth muscle cell proliferation, extracellular matrix production, and recruitment of T cells - Lipid accumulation both extracellularly and within cells (macrophages and smooth muscle cell).In descending order, the most extensively involved vessels are the lower abdominal aoa, the coronary aeries, the popliteal aeries, the internal carotid aeries, and the vessels of the circle of Willis. In humans, the abdominal aoa is typically involved to a much greater degree than the thoracic aoa.