This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
CD59 deficiency leads to: 
Select and explain. 
A. PNH, B. Chediak-Higashi disease, C. Hairy cell leukemia, D. Hemolytic uremic syndrome
A: PNH
Answer: A: PNH 
Explanation: Ref. Robbins Pathology. 9th edition. Page. 642
PNH :

Defect in GPI linked proteins  - CD55 and CD 59
Mutation in PIGA gene
Intravascular hemolysis
Triad – IV hemolysis, Thrombosis, Pancytopenia
Can result in AML
Diagnostic methods


HAM test – no more used
Gel card test
Flow cytometry – IOC
Best – FLAER (Fluorescent Aerolysin test)