This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Irreversible cell Injury/Necrosis, Subject name: Pathology
Enzymatic degradation of chromatin by endonucleases is referred to as: 
Select and explain. 
A. Karyolysis, B. Pyknosis, C. Karyorrhexis, D. None of the above
A: Karyolysis
Answer: A: Karyolysis 
Explanation: During necrosis, nuclear changes appear in one of three patterns, all due to nonspecific breakdown of DNA. Karyolysis (dissolution)-complete dissolution of the chromatin of a dying cell due to enzymatic degradation by endonucleases. Pyknosis (condensation)-irreversible condensation of chromatin in the nucleus of the cell undergoing necrosis or apoptosis. characterized by nuclear shrinkage and increased basophilia. Karyorrhexis (fragmentation)- destructive fragmentation of the nucleus of a dying cell whereby its chromatin is distributed irregularly throughout the cytoplasm.