This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology Pa 1 (Immune Response, Antigen-Antibody Reactions, Hypersensitivity, Structure of Immune System, Immunodeficiency Disorders), Subject name: Microbiology
Recurrent Neisseria infections are not predisposed by- 
Select and explain. 
A. Early complement component deficiency, B. Late complement component deficiency, C. Factor D deficiency, D. Properdin deficiency
A: Early complement component deficiency
Answer: A: Early complement component deficiency 
Explanation: Option 1, 2, 3, 4 Inherited or acquired deficiency of C5-8 (late components) components greatly enhances susceptibility to Neisseria bacteremia and other infections. Deficiency of C3 leads to severe recurrent pyogenic sinusitis and respiratory infections. Deficiency of Properdin and factor D (Alternative pathway Deficiency) lead to Neisserial infection and pyogenic infections. Early complement component (C1, C2, C3, C4) deficiency: SLE, glomerulonephritis and pyogenic infections.