This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diabetes Mellitus, Subject name: Medicine
The earliest finding in Diabetic nephropathy is? 
Select and explain. 
A. Shrunken kidney is hallmark, B. Fibrin Caps, C. Elevated Creatinine Clearance, D. Urine albumin > 30 mg/dl
D: Urine albumin > 30 mg/dl
Answer: D: Urine albumin > 30 mg/dl 
Explanation: For early diagnosis of Diabetic Nephropathy, Quantification of 24-h urinary excretion of albumin is the best screening test. Initiation of ACE inhibitors will prevent progression to ove proteinuria and decline in GFR. Macroalbuminuria(Urinary protein > 550 mg/day) in 3 consecutive samples- A reliable indicator of Diabetic nephropathy. Earliest manifestation of diabetic nephropathy is increased GFR