This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Histology of Alpo syndrome - 
Select and explain. 
A. Foamy cells in interstitium, B. Foamy cells in tubular epithelial cells, C. Thickening of GBM > 100 nm, D. All
A: Foamy cells in interstitium
Answer: A: Foamy cells in interstitium 
Explanation: Ans. is 'a' i.e., Foamy cells in interstitiumHistological characteristics of Alpo - syndrome :o Diffuse basement membrane thinningo Foam cell in interstitium -4 Due to accumulation of neutral fat and mucopolysaccharideo In advanced stage there is focal or global glomerulosclerosis.o Vascular sclerosiso Tubular atrophyo Interstitial fibrosiso The GBM shows irregular foci of thickening alternating with thinning, with pronounced splitting and lamination of the lamina densa, often with a distinctive basket - weave appearance.