This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
Oral anticoagulants given to pregnant women cause 
Select and explain. 
A. Long bones limb defect, B. Craniofacial malformation, C. CVS malformation, D. Costochondro dysplasia
B: Craniofacial malformation
Answer: B: Craniofacial malformation 
Explanation: Contradi's syndrome (Skeletal and facial anomalies optic atrophy, microcephaly, chondrodysplasia punctate. Warfarin given in early pregnancy increases bih defects, specially skeletal abnormality foetal warfarin syndrome - hypoplasia of nose, eye socket hand bones, growth retardation. Given later in pregnancy - it can cause CNS defects, foetal haemorrhage, foetal death and accentuates neonatal hypoprothrombinemia Ref: Katzung 12 th ed.