This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
Which of the following drugs has covalent interaction with its target 
Select and explain. 
A. Aspirin, B. Penicillin, C. Nitric oxide, D. Bosentan
A: Aspirin
Answer: A: Aspirin 
Explanation: Aspirin is Acetylsalicylic acid conves to salicylic acid in the body, responsible for the action. It acts irreversibly by binding to cox enzyme through covalent- strong bonds ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION; KD TRIPATHI;PAGE NO 195