This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In triple response, flare is mediated by which reflex?- 
Select and explain. 
A. Axon reflex, B. Capillary reflex, C. Arterial reflex, D. Venous reflex
A: Axon reflex
Answer: A: Axon reflex 
Explanation: The triple response of Lewis is a cutaneous response that occurs from firm stroking of the skin, which leads to the following sequence of events.
1) Red spot: due to capillary dilatation
2) Flare: redness in the surrounding area due to arteriolar dilatation mediated by axon reflex.
3) Wheal: due to exudation of fluid from capillaries and venules
The triple response of Lewis is due to the release of histamine.