This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The apparent volume of distribution (Vd) of a drug exceeds total body fluid volume, if a drug is: 
Select and explain. 
A. Sequestrated in body tissues, B. Slowly eliminated from body, C. Poorly soluble in plasma, D. Highly bound to plasma proteins
A: Sequestrated in body tissues
Answer: A: Sequestrated in body tissues 
Explanation: - The apparent volume of Distribution (Vd) = Dose administered by IV route/Plasma concentration.
- Consider the body as a single compartment in which the drug gets homogenously distributed. So it can be defined as, “The volume that would accommodate all the drug in the body if the concentration throughout was the same as in plasma.”
- In the case of lipid insoluble drugs, drugs do not enter the cells. So their V will be similar to ECF volume. 
- Drugs sequestrated in other tissues may have V much more than total body water or even body mass.