This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
Bleomycin toxicity affects which organ predominantly? 
Select and explain. 
A. Bone marrow, B. Lungs, C. Liver, D. RBC
B: Lungs
Answer: B: Lungs 
Explanation: Bleomycin is metabolized by bleomycin hydrolase. This enzyme is deficient in skin and lungs. Therefore, the major adverse effects of bleomycin are: Flagellated pigmentation of skin Pulmonary fibrosis