This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
Gemfibrozil is:- 
Select and explain. 
A. HMG CoA inhibitor, B. PPAR-a activator, C. Inhibit cholesterol synthesis, D. Inhibit cholesterol absorption
B: PPAR-a activator
Answer: B: PPAR-a activator 
Explanation: Gemfibrozil: MOA: Activation of the nuclear transcription receptor "peroxisome proliferator - activated receptor alpha" (PPAR-a). Major effects are to increase plasma HDL and to decrease plasma TG. Myopathy risk highest when used with statins Statins: Inhibit HMG COA reductase Inhibit cholesterol synthesis. EZETIMIBE- Inhibit intestinal cholesterol absorption.