This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
Prodrug of cetrizine is - 
Select and explain. 
A. Foxefenadone, B. Terfenadine, C. Hydroxyzine, D. Azelastine
C: Hydroxyzine
Answer: C: Hydroxyzine 
Explanation: Ans. is 'c' i.e., Hydroxyzine o Cetrizine is a metabolite of Hydroxyzine with marked affinity for peripheral H1 receptors; penetrates brain poorly,o It inhibits release of histamine and of cytotoxic mediators from platelets as well as eosinophil chemotaxis during secondary phase of allergic response.o It is indicated in upper respiratory allergies, pollinosis, urticaria and atopic dermatitis; also used as adjuvant in seasonal asthama.