This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Calcium channel blocker causing cerebral vasodilatation is: September 2006 
Select and explain. 
A. Nimodipine, B. Felodipine, C. Amlod ipine, D. Nitrendi pine
A: Nimodipine
Answer: A: Nimodipine 
Explanation: Ans. A: Nimodipine Nimodipine binds specifically to LAN/1)e voltage-gated calcium channels. Nimodipine penetrates blood-brain barrier very effectively due to high lipid solubility. It effectively relaxes cerebral vasculature; approved for prevention and treatment of neurological deficit due to cerebral vasospasm following subarchnoid hemorrhage or ruptured congenital intracranial aneurysms. Adverse effects paicularly, in high dosage group (90 mg) includes itching, gastrointestinal hemorrhage, thrombocytopenia, neurological deterioration, vomiting, diaphoresis, congestive hea failure, hyponatremia, decreasing platelet count, disseminated intravascular coagulation and deep vein thrombosis.