This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pediatrics
Pseudohypoparathyroidism is characterized by: 
Select and explain. 
A. Normal serum Ca++ and decreased serum PTH, B. Decreased serum Ca++ and decreased serum PTH, C. Decreased serum Ca++ and Increased serum PTH, D. Normal serum Ca++ and Increased serum PTH
C: Decreased serum Ca++ and Increased serum PTH
Answer: C: Decreased serum Ca++ and Increased serum PTH 
Explanation: c. Decreased serum Ca++ and Increased serum PTH(Ref: Nelson's 20/e p 2695-2697, Ghai 8/e p 521-524)Pseudohypoparathyroidism (PHP)Parathyroid glands are normal or hyperplastic and they can synthesize and secrete parathyroid hormone (PTH)Serum levels of immunoreactive PTH are elevated even when the patient is hypocalcemic normocalcemicNeither endogenous nor administered PTH raises the serum levels of calcium or lowers the levels of phosphorus.