This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Alpha-1 antitrypsin acts to prevent lung tissue destruction by 
Select and explain. 
A. Inhibiting the release of trypsin, B. Inhibiting the activation of trypsinogen, C. Inhibiting the release of chymotrypsin, D. Inhibiting the elastase of neutrophils in lung
D: Inhibiting the elastase of neutrophils in lung
Answer: D: Inhibiting the elastase of neutrophils in lung 
Explanation: Answer- D. Inhibiting the elastase of neutrophils in lungThe most accepted theory in the pathogenesis of emphysema is protease - antiprotease mechanism which is responsible in the pathogenesis of two common forms of emphysema, i.e. centriacinar and panacinar.A) Pathogenesis of panacinar emphysemaPanacinar emphysema is associated wlth congenital deficiency of alpha 1-antitrypsin.Neutrophil are the major cell in the pathogenesis of panacinar emphysema.B) Pathogenesis of centriaginar emphysema in centriacinar emphysema, both neutrophils and macrophages play central role.