This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
When nitrates are combined with calcium channel blockers: 
Select and explain. 
A. Aerial pressure will decrease, B. Hea rate will increase, C. Ejection time will decrease, D. End-diastolic volume will increase
A: Aerial pressure will decrease
Answer: A: Aerial pressure will decrease 
Explanation: Nitrates primarily decrease preload, while CCBs have a greater effect on afterload. Their concurrent use may decrease cardiac work to an extent not possible with either drug alone. This combination may be especially valuable in severe vasospastic angina. Eg for nitrates: GTN CCBs-amlo,felo,clevidipine, verapamil, diltiazem K D Tripathi: essentials of medical pharmacology; edition 6; pg no:533