This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
Regan isoenzyme is increased in 
Select and explain. 
A. Seminoma, B. Paget's disease, C. Osteoporosis, D. Cholestasis
A: Seminoma
Answer: A: Seminoma 
Explanation: The Regan isoenzyme is a placental-type alkaline phosphatase that is expressed in a number of human tumors, paicularly in gonadal and urologic cancers. Evidence now points to seminoma as a consistent producer of Regan isoenzyme although much more work will be required to establish its clinical utility. Ref: