This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Auto antibody in Sjogrens syndrome is? 
Select and explain. 
A. Anti centromere antibody, B. Anti Ro & anti La, C. Anti ds DNA, D. Anti RNP
B: Anti Ro & anti La
Answer: B: Anti Ro & anti La 
Explanation: Robbins basic pathology 9th edition page no 131,(green box=Pathogenesis) Most patients with primary sjogren syndrome have auto antibodies to the ribo-nucleoprotien (RNP) antigensSS-A(RO) and SS-B(la).