This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Hypercoagulation in Nephrotic syndrome is caused by: 
Select and explain. 
A. Loss of Antithrombin III, B. Decreased Fibrinogen, C. Decreased Metabolism of Vitamin K, D. Increase in protein C
A: Loss of Antithrombin III
Answer: A: Loss of Antithrombin III 
Explanation: Answer is A (Loss of Antithrombin III) Loss of Antithrombin III contributes to the hypercoagulable state in Nephrotic syndrome `A hypercoagulable state frequently accompanies severe nephrotic syndrome due to urinary losses of antithrmbin reduced serum levels of protein C and S, hyperfibrinogenemia and enhanced platelet aggregation'