This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Anatomy
Central dot is seen in 
Select and explain. 
A. Primary sclerosing cholangitis, B. Liver hamaoma, C. Caroli's disease, D. Polycystic liver disease
C: Caroli's disease
Answer: C: Caroli's disease 
Explanation: Caroli's disease Clinical features Symptoms include cholangitis (64%), poal hypeension (22%), and abdominal pain (18%) More common in males Septa containing poal veins protrude into the lumen of the ecstatic bile ducts (central dot sign) The main and often the only symptom of bacterial cholangitis secondary to caroli's disease is fever without abdominal pain and jaundice Frequent episodes of cholangitis indicates poor prognosis Most stones are pigmented in caroli's disease Ref: Sabiston 20th edition Pgno :1511