This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The most important adverse effect of i.v. administration of large dose of an amide anaesthetic is : 
Select and explain. 
A. Bronchoconstriction, B. Hepatic damage, C. Renal failure, D. Seizures
D: Seizures
Answer: D: Seizures 
Explanation: None