This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Blood, Subject name: Pathology
ADAMTS 13 is associated with: 
Select and explain. 
A. TTP, B. Churg Strauss, C. Wegener, D. Membranous nephropathy
A: TTP
Answer: A: TTP 
Explanation: Ans. a. TTPThrombotic thrombocytopenic purpura (TTP) is a rare disorder of hemostasis in which there is widespread intravascular formation of fibrin-platelet thrombi.It is sometimes associated with an acquired or inherited deficiency of the enzyme ADAMTS 13, responsible for cleaving large multimers of von Willebrand factor.Clinically, TTP most often affects adult women.The inclusion criteria are microangiopathic hemolytic anemia and thrombocytopenia, with or without renal failure or neurologic abnormalities.Pathology includes widespread formation of platelet thrombi with fibrin (hyaline thrombi) leading to intravascular hemolysis (thrombotic microangiopathy).