This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: D.O.C, Subject name: Pharmacology
Drug of choice for peptic ulcer disease caused by chronic use of NSAIDS: 
Select and explain. 
A. Pirenzepine, B. Loratadine, C. Misoprostol, D. Esomeprazole
D: Esomeprazole
Answer: D: Esomeprazole 
Explanation: Ans. D. EsomeprazoleMisoprostol and esomeprazole are both used for NSAID induced ulcer. But PPI are more efficacious for this condition.