This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following Interleukin is raised in a fever? 
Select and explain. 
A. IFN-γ, B. TNF-α, C. IL-10, D. IL-2
B: TNF-α
Answer: B: TNF-α 
Explanation: i.e., TNF-α 
“IL-1 and TNF-α are the two most important pyrogens” — Physiology basics.
Pyrogens

Pyrogens are substances that cause fever.
Pyrogens may be exogenous or endogenous

a) Exogenous → Bacterial toxins
b) Endogenous → IL-1, TNF-a, IL-6, Interferons, Ciliary neurotrophic factor

These pyrogens increase the level of PGE2 in the hypothalamus that elevates the thermoregulatory set point and causes fever.