This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Systemic Pathology, Subject name: Pathology
Most common tumor in a female diagnosed with tuberous sclerosis is: 
Select and explain. 
A. Rhabdomyosarcoma, B. Renal Angiomyolipoma, C. Pulmonary lymphangioleiomyomatosis, D. Optic glioma
B: Renal Angiomyolipoma
Answer: B: Renal Angiomyolipoma 
Explanation: Tuberous Sclerosis:- AD syndrome Mutation of TSC : TSC 1/TSC2 gene Organ:- CNS :- Hamaoma :- Epilepsy. Renal:- Angiomyolipoma Eye:- Retinal glial hamaomas Lungs:- Pulmonary lymphangioleiomyomatosis. Hea:- Rhabdomyomas Skin :- lathery thickening (shagreen Patch) Ash leaf patch Subungual fibroma. CNS manifestation is most common which is epilepsy. Angiomyolipoma is most common tumor in female diagnosed with Tuberous Sclerosis Angiomyolipoma is a benign renal neoplasm originating from perivascular epithelioid cells (PEComa), It consists of vessels, smooth muscle, and fat in variable propoions (as shown in the image above)