This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The development of resistance to conventional treatment has led WHO to recommend the use of combination therapies containing artemisinin derivative (artemisinin-based combination therapies also known as ACTs). All of the following combination therapies are recommended if such resistance is suspected, except 
Select and explain. 
A. Artemether plus lumefantrine, B. Artesunate plus quinine, C. Artesunate plus pyrimethamine-sulfadoxine, D. Artesunate plus mefloquine
B: Artesunate plus quinine
Answer: B: Artesunate plus quinine 
Explanation: The WHO recommended ACTs include:

Artemether-lumefantrine
Artesunate-amodiaquine
Artesunate-mefloquine
Artesunate-sulfadoxine-pyrimethamine
Dihydroartemisinin-piperaquine