This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Pharmacology
Maximum extrapyramidal side-effect is seen with: 
Select and explain. 
A. Haloperidol, B. Chlorpromazine, C. Imipramine, D. Clomipramine
A: Haloperidol
Answer: A: Haloperidol 
Explanation: Ans. A. HaloperidolTypical antipsychotic drugs are known to cause extrapyramidal side effects. They block D2 receptors. They are of two types: high potency and low potency. High potency drugs like haloperidol are known to cause maximum EPS. Low potency drugs like chlorpromazine have alpha blocking properties and show anticholinergic side effects.