This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
Organophosphate sacked by inhibiting the enzyme acetylcholinesterase. Which type of enzyme inhibitors are they 
Select and explain. 
A. Competitive and reversible, B. Non competitive and Irreversible, C. Uncompetitive and reversible, D. Competitive and Irreversible
B: Non competitive and Irreversible
Answer: B: Non competitive and Irreversible 
Explanation: Refer Goodman and Gilman 12e 242, Katzung 12e p106 Both organophosphates and Karbonn its cause competitive inhibition of acetylcholinesterase by binding to estaratic site. However organophosphates are Irreversible and most carbamates(except carbamyl and propoxures) are reversible inhibitors. Thus the type of inhibition of acetylcholinesterase caused by organophosphates is competitive and Irreversible