This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
In Marfan&;s syndrome defect is in 
Select and explain. 
A. Fibrillin I, B. Fibrillin II, C. Collagen, D. Elastin
A: Fibrillin I
Answer: A: Fibrillin I 
Explanation: Marfan syndrome is caused by a mutation in FBNI gene encoding fibrillin. The major tissue effected are skeleton, eyes and cardiovascular system Refer robbins 146