This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
Long-term use of which of the following diuretic agent results in gynaecomastia? 
Select and explain. 
A. Amiloride, B. Spironolactone, C. Triamterene, D. Acetazolamide
B: Spironolactone
Answer: B: Spironolactone 
Explanation: Potassium-sparing diuretics may produce hyperkalemia, paicularly in patients with renal insufficiency and those taking ACE inhibitors or angiotensin receptor blockers; Spironolactone is associated with gynecomastia- as it inhibits aldosterone Reference: Katzung Pharmacology; 13th edition; Chapter 11; Antihypeensive Agents