This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
A child was diagnosed as a case of pauci-immune crescentic glomerulonephritis. The treatment to be given in this child is - 
Select and explain. 
A. Prednisolone + Cyclophosphamide, B. Methylprednisolone, C. Cyclophosphamide, D. Immunoglobins
A: Prednisolone + Cyclophosphamide
Answer: A: Prednisolone + Cyclophosphamide 
Explanation: Ans. is 'a' i.e., Prednisolone + cyclophosphamide Pauci-immune glomerulonephritis o Pauci-immune glomerulonephritis is defined as the lack of anti-GBM antibodies or immune complex. It is a type of rapidly progressive glomerulonephritis. o Causes are :- Idiopathic renal-limited crescentic glomerulonephritis (ANCA associated). Microscopic polyangitis Microscopic PAN Wegner granulomatosis It is treated aggressively with glucocoicoids with or without cyclophosphamide or azathioprine.