This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cytotoxic Anticancer Drugs, Subject name: Pharmacology
Drugs which affect DNA synthesis or replication are all except:- 
Select and explain. 
A. 5-FU, B. Bevacizumab, C. Doxorubicin, D. Methotrexate
B: Bevacizumab
Answer: B: Bevacizumab 
Explanation: Bevacizumab is a monoclonal antibody against VEGF. It acts by inhibiting angiogenesis. Doxorubicin is a topoisomerase inhibitor and inhibit the uncoiling of DNA and thus replication. 5-FU is a pyrimidine analog and inhibit DNA synthesis by competing with DNA polymerase. Methotrexate is a dihydro folic acid reductase inhibitor. It decreases the formation of DNA.