This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T., Subject name: Pathology
Positive acid Schiff macrophages seen in? 
Select and explain. 
A. Whipple disease, B. Crohn's disease, C. Abetalipoproteinemia, D. Ulcerative colitis
A: Whipple disease
Answer: A: Whipple disease 
Explanation: Ans. a. Whipple diseaseRef: Robbins and Cotran Pathologic Basis of Disease 9th Ed; Page No- 791Whipple DiseaseInfection with Tropheryma whipplei (intracellular gram [?]); PAS [?]Foamy macrophages in intestinal lamina propria.Cardiac symptoms, Arthralgias, and Neurologic symptoms are common.Diarrhea/steatorrhea occurs later in disease course.Most common in older men.