This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Amyotrophic lateral sclerosis involves: 
Select and explain. 
A. Upper motor neuron and lower motor neuron both, B. Posterior column only, C. Lower motor neuron only, D. Raphae nucleus
A: Upper motor neuron and lower motor neuron both
Answer: A: Upper motor neuron and lower motor neuron both 
Explanation: A i.e. Upper motor neuron and lower motor neuron both.Amyotrophic lateral sclerosis is the most common form of progeressive motor neuron disease. It involves both upper motor neuron (UMN) & lower motor neuron (LMN)Q.Motor neuron disease Is characterized by degeneration of motor neurons, either upper motor neuron or lower motor neuron or both.