This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
Rate limiting step in cholesterol synthesis is inhibited by 
Select and explain. 
A. Probucal, B. Statins, C. Cholistyramine, D. Gemfibrozil
B: Statins
Answer: B: Statins 
Explanation: Refer kDT 6/e p 614 About 80% of total daily cholesterol production occurs in the liver and the intestines; other sites of higher synthesis rates include adrenal glands, and reproductive organs. Synthesiswithin the body stas with the mevalonate pathway where two molecules of acetyl CoA condense to form acetoacetyl-CoA. Statins inhibit HMG-CoA reductase and decrease cellular cholesterol synthesis. ... The over-expression of the LDL-receptor in the liver increases the clearance of circulatingLDL, decreasing the LDL-cholesterol plasma levels.