This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
A patient on chronic use of NSAIDs has developed peptic ulcer. DOC to treat the condition is: 
Select and explain. 
A. Pirenzepine, B. Loxatidine, C. Misoprostol, D. Esomeprazole
D: Esomeprazole
Answer: D: Esomeprazole 
Explanation: Proton pump inhibitors are the drugs of choice for peptic ulcer disease due to any aetiology. 
Misoprostol is the most specific drug for the treatment of PUD due to chronic NSAID use, because it is a PGE1 analogue.
PUD = Peptic Ulcer Disease.