This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Adrenal Gland, Subject name: Medicine
Congenital 17-hydroxylase deficiency leads to hypeension due to accumulation of? 
Select and explain. 
A. Deoxycoicosterone, B. Coisol, C. 17 hydroxy pregnediol, D. 17 hydroxy progesterone
A: Deoxycoicosterone
Answer: A: Deoxycoicosterone 
Explanation: * Two forms of adrenal hyperplasia (ie, 11-hydroxylase and 17-hydroxylase deficiency) result in hypeension due to the accumulation of supraphysiologic concentrations of deoxycoicosterone. * This weak mineralocoicoid has little consequence at physiologic concentrations but causes sodium retention and hypeension at the supraphysiologic concentrations that occur in these conditions.