This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET 2018, Subject name: Pharmacology
Coagulation testing in needed for:- 
Select and explain. 
A. Lepirudin, B. Enoxaparin, C. Fondaparinux, D. Dabigatran
A: Lepirudin
Answer: A: Lepirudin 
Explanation: Coagulation testing is mainly done for: * Warfarin(vitamin K antagonist) : it is monitored by prothrombin time(PT) or International Normalised Ratio(INR). * Unfractionated Heparin : it is monitered by aPTT. Other anti-coagulants requiring monitoring are direct thrombin inhibitors like: * Lepirudin * Bivalirudin They require monitoring by aPTT. Recently, new oral anti-coagulants are developed which do not require monitoring, e.g. include : * Dabigatran(direct thrombin inhibitor) * Epixaban(factor XA inhibitors) Fondaparinux and Low molecular weight heparin (indirect thrombin inhibitors) do not require monitoring.