This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
The earlies antibody marker to appear In the serum in Hepatitis B virus infection Is- 
Select and explain. 
A. Anti-HBs, B. Anti-HBe, C. Anti-HBc, D. Anti-Hbx
C: Anti-HBc
Answer: C: Anti-HBc 
Explanation: <P>Davidson&;s principles and practice of medicine 22nd edition. #HBc Ag is not found in blood but antibody to it appeared early in the illness (incubation period) and rapidly reached a high titre which subsides gradually but then persist.</p>