This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
The earliest symptom in primary biliary cirrhosis is 
Select and explain. 
A. Jaundice, B. Pruritus, C. Melanosis, D. Vomiting
B: Pruritus
Answer: B: Pruritus 
Explanation: Pruritis occurs because of deposition of bile salts in the skin, this clinical symptom occurs before the development of jaundice.