This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Asthma, Subject name: Medicine
Antibody in asthma treatment- 
Select and explain. 
A. Omalizumab, B. Rituximab, C. Transtusuzumab, D. Daclizumab
A: Omalizumab
Answer: A: Omalizumab 
Explanation: Ans. is 'a' i.e., OmalizumabOmalizumabo Omalizumab is an anti IgE agent approved by the (FDA) for use in patients age 12 and above with moderate to severe persistent allergic asthma with : -An IgE level of30-700 lu/ml.Positive allergen skin or specific IgE tests to a perenmial allergen andIncomplete symptom control with inhaled glucocorticoid treatment.o Omalizumab is administered by "subcutaneous injection " every mo to four weeks in a dose that is determined by- body weights and the level of serum IgE.o Omalizumab produces 25% reduction in rate of asthma exacerbations.o The response to omalizumab therapy is variable and difficult to predict with overall response rates in patients with moderate to severe asthma averaging 30-50%.o A minimum of 12 weeks of treatment is necessary to determine the efficacy1 ofanti-IgE therapy.