This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bater syndrome, Gitelman syndrome, Liddle and Comparison with SIADH, Subject name: Medicine
Causes of severe hypokalemic metabolic alkalosis with severe hypeension include 
Select and explain. 
A. Liddle syndrome, B. Bater syndrome, C. Gitelman syndrome, D. Renal tubular acidosis
A: Liddle syndrome
Answer: A: Liddle syndrome 
Explanation: Liddle syndrome - AD, gain-in-function mutations of ENaC subunits. Activating kidneys to excrete potassium retaining excessive sodium & water, leading to hypeension. C/F- severe hypeension with hypokalemia, unresponsive to spironolactone yet sensitive to amiloride