This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Surgery
What is true of pepsinogen? 
Select and explain. 
A. Is a condition in which it is safe to leave microscopic disease at the cut edges, B. Shows favorable response to radiotherapy, C. Has a 5-year survival rate of about 12%, D. Rates are increased in patients with duodenal ulcer
C: Has a 5-year survival rate of about 12%
Answer: C: Has a 5-year survival rate of about 12% 
Explanation: Survival rates are increased in patients with gastric ulcer. The 5-year survival rate for all types of gastric carcinoma is about 12%, but it is 35% if the nodes are clear and 7% if the nodes are involved. It is important that the cut edges are clear of tumor to avoid almost certain recurrence.