This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anesthesia, Subject name: Pharmacology
The primary mechanism of action of local anesthetics is 
Select and explain. 
A. Blockade of voltage-gated sodium channels, B. Stimulation of voltage-gated N-type calcium channels, C. Activation of ligand-gated potassium channels, D. Blockade the GABA-gated chloride channels
A: Blockade of voltage-gated sodium channels
Answer: A: Blockade of voltage-gated sodium channels 
Explanation: The primary mechanism of action of local anaesthetics is the blockade of voltage-gated sodium channels <img class="fr-fic fr-dib" style="width: 300px;" src=" /> Ref: Katzung 13e pg:443