This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
Destruction of the enamel knot leads to: 
Select and explain. 
A. Cessation of further tooth development., B. Dentinogenesis imperfecta., C. Amelogenesis imperfecta., D. None.
A: Cessation of further tooth development.
Answer: A: Cessation of further tooth development. 
Explanation: Enamel knot is an important signalling centre for the proliferation and growth of the dental papilla.
Destruction of enamel knot leads to cessation of further tooth development.