This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Congenital malformations, Subject name: Gynaecology & Obstetrics
Which of the following is responsibile for pubeal growth in females 
Select and explain. 
A. Decreased level of adrenal androgens at pubey, B. Low level of estrogen at pubey, C. Pulsatile release of GnRh during sleep, D. Increased sensitivity of HPO axis to estrogen
C: Pulsatile release of GnRh during sleep
Answer: C: Pulsatile release of GnRh during sleep 
Explanation: The GnRH pulses from the hypothalamus results in pulsatile gonadotropin secretion GnRH > FSH,LH > Estradiol Gonadal estrogen is responsible for the development of uterus,vagina and breasts D.C.DUTTA&;S TEXTBOOK OF GYNAECOLOGY, Pg no:50, 6th edition