This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Anaesthesia
Malignant hypehermia is caused due to which of the following mechanism? 
Select and explain. 
A. Increased intracellular NA, B. Decreased intracellular chlorine, C. Increased intracellular Ca, D. Increased serum K
C: Increased intracellular Ca
Answer: C: Increased intracellular Ca 
Explanation: The mechanism involves a sudden rise in intracellular calcium due to release of stored calcium in sarcoplasmic reticulum, stimulating contraction, rhabdomyolysis and a hypermetabolic state.(Refer: stoelting's pharmacology and physiology in anaesthetic practice, 5th edition, pg no.823)