This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Substance Abuse, Subject name: Psychiatry
Tolerance means? 
Select and explain. 
A. Increase effect of drug on same dose, B. Decrease effect of drug on same dose, C. Same effect on lesser doses, D. None
B: Decrease effect of drug on same dose
Answer: B: Decrease effect of drug on same dose 
Explanation: Ans. is 'b' i.e., Decrease effect of drug on same dose * Tolerance means same dose produces markedly diminished effect on continuous use, therefore increased doses are required to produce same effect.* It is seen in alcohol dependent syndrome 8c has been included in its diagnostic criteria.