This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
The plasma half life of aspirin: 
Select and explain. 
A. Is independent of dose, B. Is longer for anti-inflammatory doses compared to that for analgesic dose, C. Is shoer for anti-inflammatory doses compared to that for analgesic dose, D. Can be increased by alkalinizing the urine
B: Is longer for anti-inflammatory doses compared to that for analgesic dose
Answer: B: Is longer for anti-inflammatory doses compared to that for analgesic dose 
Explanation: Aspirin and other salicylates show saturation kinetics (zero order) and thus, their half life is not constant. Clearance at high doses (anti-inflamatory) is lesser than at low (analgesic) doses. Thus t1/2 is more for anti-inflammatory dose than for analgesic dose.