This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
Hurler syndrome is due to deficiency of 
Select and explain. 
A. Beta galactosidase, B. Sphingomyelinase, C. Heparitin Sulphate, D. Hyaluronidase
C: Heparitin Sulphate
Answer: C: Heparitin Sulphate 
Explanation: Heparitin Sulphate Isolated from amyloid liver, ceain normal tissues such as human and cattle aoa, and from the urine, liver, and spleen of patients with gargoylism (Hurler's syndrome). This compound has negligible anticoagulant activity. It seems to be structurally similar to heparin, but has a:Lower molecular weight,Some of the amino groups carry acetyl groups and percentage of -SO4 groups are smaller.Unlike heparin, its predominant uronic acid is D-Glucuronic acid (Glc UA).Recently it has been shown that it is present on cell surfaces as proteoglycan and is extracellular.Ref: M.N. Chatterjea - Textbook of Biochemistry, 8th edition, page no: 40