This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Resolution of inflammation is caused by? 
Select and explain. 
A. TNF Alfa, IL-1 and CRP, B. TNF beta, IL-6 and CRP, C. TNF Alfa, IL 10 and IL 1 receptor antagonist, D. TNF gamma
C: TNF Alfa, IL 10 and IL 1 receptor antagonist
Answer: C: TNF Alfa, IL 10 and IL 1 receptor antagonist 
Explanation: Antiinflammatory mediators terminate the acute inflammatory reaction when it is no longer needed the anti-inflammatory cytokines: IL-10, TGF-b, IL-4, IL-13 pro-inflammatory cytokines: IL-1, IL-6, TNF-alpha Interleukin 10 (IL-10) has been proposed as having an inhibitory effect on the production of several inflammatory cytokines including TNF-alpha. ... Lipopolysaccharide-induced TNF-alpha production in peripheral blood monocytes was reduced from 2.035 (0.284) to 0.698 (0.167) ng/ml. ref robbins basic pathology 9th ed page 48