This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
Nitroglycerine is effective when administered sublingually because it is: 
Select and explain. 
A. Non ionized and lipid soluble, B. Ionized and lipid soluble, C. Non ionized and Water insoluble, D. Ionized and water insoluble
A: Non ionized and lipid soluble
Answer: A: Non ionized and lipid soluble 
Explanation: Ans. (A) Non ionized and lipid soluble(Ref: KDT 8th/e p28)Nitroglycerin is effective when retained sublingually because it is non-ionized and has very high lipid solubility. Thus, the drug is absorbed very rapidly.