This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which diuretic could be considered appropriate for combining with ACE inhibitors - 
Select and explain. 
A. Spironolactone, B. Eplerenone, C. Hydrochlorothiazide, D. Amiloride
C: Hydrochlorothiazide
Answer: C: Hydrochlorothiazide 
Explanation: Ans. is 'c' i.e., Hydrochlorothiazide ACE inhibitor and diuretics o ACE inhibitors cause hyperkalemia, therefore they can be combined with furosemide or thiazide diuretics which cause hypokalemia and nullify the hyperkalemic effect of ACE inhibitors. o On the other hand potassium sparing diuretics (spironolactone, eplerenone, ami 1 oridc, triamterene) are contraindicated as they cause hyperkalemia and aggrevate the hyperkalemia caused by ACE inhibitors.