This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Ophthalmology
Brushfield spot in iris is seen in- 
Select and explain. 
A. Neurofibromatosis, B. Down syndrome, C. Ttoberous sclerosis, D. Toxoplasmosis
B: Down syndrome
Answer: B: Down syndrome 
Explanation: Brushfield spots are small, white or grayish/brown spots on the periphery of the iris due to aggregation of connective tissue. Seen in Down syndrome patients of European descent. Other ocular features in Down syndrome: Epicanthal folds Mongoloid slanting of eye Myopia Keratoconus Esotropia Congenital Cataract Blepharitis In Neurofibromatosis, Lisch nodules are seen.