This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
All of the following are histopathological findings of papillary carcinoma, except 
Select and explain. 
A. Orphan Annie eye nuclei, B. Psammoma bodies, C. Monofocal papillary projections, D. Intranuclear grooves
C: Monofocal papillary projections
Answer: C: Monofocal papillary projections 
Explanation: Pathology

Papillary projections
Psammoma bodies (concentric calcifications)
Pale empty (orphan annie) nuclei → FINELY DISPERSED CHROMATIN IMPARTS AN EMPTY APPEARANCE


Intranuclear grooves and nuclear characteristics are diagnostic of papillary carcinoma
Multifocality is common in papillary carcinoma
TSH levels are high; tumors are TSH dependent, hence follow-up with TSH.

Key Concept:

Multifocality is common (up to 85% of cases) on microscopic examination.
Multifocality is associated with an increased risk of cervical nodal metastases, rarely invade adjacent structures such as the trachea, esophagus, and RLNs.

RLN implies lymph nodes.