This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anatomy
Primary defect in structure is known as : 
Select and explain. 
A. Malformation, B. Deformation, C. Disruption, D. Sequence
A: Malformation
Answer: A: Malformation 
Explanation: A malformation is a congenital anomaly due to an intrinsic defect in development which gives a primary defect in structure. A deformation is an abnormal development of an organ due to an extrinsic process. A disruption occurs when a normally developing organ is secondarily damaged by another process. For example, in amniotic band syndrome, a fragment of the amniotic membrane wraps around a poion of the body and damages or amputates it. A sequence is a collection of several anomalies, all of which are due to one malformation, disruption, or deformation.