This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Seen in rickets A/E –a) Cupping of metaphysicb) Defective Mineralizationc) Epiphyseal dysgenesisd) Defective osteoid formation 
Select and explain. 
A. ab, B. cd, C. bd, D. ac
B: cd
Answer: B: cd 
Explanation: In rickets osteoid (protein matrix) is formed normally but mineralization of this osteoid does not occur i.e. there is defective mineralization.

Pathophysiology of rickets 
1)   Normal anatomy and physiology of mineralization

Normal growing bone has following regions (moving from end to centre) -