This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
Poor prognostic factor in ALL are - 
Select and explain. 
A. Philadelphia chromosome, B. Male sex, C. High WBC count, D. Hyperploidy
A: Philadelphia chromosome
Answer: A: Philadelphia chromosome 
Explanation: Person with t(9,22) positive-ALL (30% of adult ALL cases) and other Bcr-abl-rearranged leukemias are more likely to have a poor prognosis, but survival rates may rise with treatment consisting of chemotherapy and Bcr-abl tyrosine kinase inhibitors Ref Davidson 23rd edition pg 933