This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of protein and amino acid, Subject name: Biochemistry
Following clinical manifestation is a feature of 
Select and explain. 
A. Hyperammonemia type 1, B. Hyperammonemia type 2, C. Argininosuccinic aciduria, D. Argininemia
C: Argininosuccinic aciduria
Answer: C: Argininosuccinic aciduria 
Explanation: Image showing Trichorrhexis nodosa. Argininosuccinic aciduria, accompanied by elevated levels of argininosuccinate in blood, cerebrospinal fluid, and urine, is associated with friable, tufted hair (trichorrhexis nodosa). It is due to the deficiency of the enzyme argininosuccinate lyase. Reference: Harpers illustrated biochemistry 30th edition