This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Null mutation is 
Select and explain. 
A. Mutation occuring in Non Coding region, B. Mutation that does not change the amino acid or end product, C. Mutation that codes for a change in progeny without any chromosomal change, D. Mutation that leads to no functional gene product
D: Mutation that leads to no functional gene product
Answer: D: Mutation that leads to no functional gene product 
Explanation: Null mutation/loss of function mutation/amorphic mutations:- These mutations are the result of gene product having less or no function. It occurs when the allele has a complete loss of function. Phenotypes associated with such mutations are most often recessive.