This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Psychiatry
Neurotransmitter changes proposed in cases of Anxiety 
Select and explain. 
A. Increased NE, and decreased GABA and serotonin, B. Decreased NE and serotonin, and increased Ach, C. Decreased GABA and Ach, D. Increased serotonin, and decreased NE and GABA
A: Increased NE, and decreased GABA and serotonin
Answer: A: Increased NE, and decreased GABA and serotonin 
Explanation: There are various neurotransmitters that is studied under the neurobiology of anxiety they are mainly as follows decreased GABA, hence benzodiazepines which acts on GABA is a onderful anti anxiety drug decrased serotonin , hence SSRI are used in management of all anxiety disorders increased norepinephrine, thus proponolol which is a beta blocker is used in the management of anxiety especially in social anxiety disorders. Reference: Kaplon and sadock, 11 th edition, synopsis of psychiatry, 11 th edition, pg no. 387