This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Surgery
Chronic treatment with tamoxifen can cause carcinoma of:- 
Select and explain. 
A. Ovary, B. Endometrium, C. Cervix, D. Vulva
B: Endometrium
Answer: B: Endometrium 
Explanation: TAMOXIFEN Tamoxifen is effective in Estrogen Receptor (ER) positive breast carcinoma but some ER negative tumors also respond to tamoxifenQ. Potent antagonist in breast carcinoma cells, blood vessels and at some peripheral sitesQ Paial agonist in the pituitary, bone, uterus and liver (Pit Bul) Adverse Effects of Tamoxifen Hot flushes, nausea & vomiting (MC)Q Menstrual irregularitiesQ, vaginal bleeding, discharge, pruritus vulvae & dermatitis Endometrial cancerQ ThromboembolismQ CataractQ Retinal deposits & decreased visual acuityQ