This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous System, Subject name: Pathology
Negri bodies are abundant in the following cells except? 
Select and explain. 
A. Subcortical white matter, B. Purkinje cells, C. Hippocampus, D. Basal ganglia
A: Subcortical white matter
Answer: A: Subcortical white matter 
Explanation: Ans. (a) Subcortical white matter(Ref: R 9th/pg 1277)*Most characteristic pathologic finding in CNS in Rabies is the formation of cytoplasmic inclusion bodies called Negri bodies Q (composed of finely fibrillar matrix and rabies virus particles)*They are most commonly seen in cerebellum (purkinje cells) & pyramidal neurons of hippocampus*Basal ganglia involvement is common*The prominence of early brain stem dysfunction Q distinguish it from other viral encephalitis.