This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
5'-Nucleotidase activity is increased in: 
Select and explain. 
A. Bone diseases, B. Prostate cancer, C. Chronic renal failure, D. Cholestatic disorder
D: Cholestatic disorder
Answer: D: Cholestatic disorder 
Explanation: Answer is D (Cholestatic disorders) 5' Nucleotidase reflects cholestasis and is rarely elevated in conditions other than liver disease. Most impoant enzymes reflecting cholestasis Alkaline phophatase 5' Nucleotidase Gamma Glutanym transpeptidase 5' Nucleotidase and GGT are the most specific marker for cholestasis and are rarely elevated in conditions other than liver disease -- Harrison