This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pancreas, Subject name: Pharmacology
True statement regarding mechanism of action of sulfonylureas is:- 
Select and explain. 
A. Increase peripheral utilization of glucose, B. Reduce hepatic glucose output, C. Act on SUR1 receptors on pancreatic beta cell membrane, D. Increase transcription of genes regulating glucose metabolism
C: Act on SUR1 receptors on pancreatic beta cell membrane
Answer: C: Act on SUR1 receptors on pancreatic beta cell membrane 
Explanation: SULFONYLUREAS These bind to sulfonuyl urea receptors 1 (SUR1) on b cells of pancreas and inhibit ATP sensitive K+ channels. This cause depolarization of b cells resulting in release of insulin. These drugs are effective only if 30 % or more of the b cells in the pancreas are available. Major limitation of these drugs is like insulin, can also cause hypoglycemia.