This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Anatomy
Gastrointestinal stromal malignancy arises from which of the following 
Select and explain. 
A. Smooth muscle, B. Nerve cells, C. Vascular endothelium, D. Interstial cells of cajal
D: Interstial cells of cajal
Answer: D: Interstial cells of cajal 
Explanation: Refer Robbins page no Pg P775 Gastrointestinal stromal tumors (GISTs) may be malignant (cancer) or benign (not cancer). They are most common in the stomach and small intestine but may be found anywhere in or near the GI tract. Some scientists believe that GISTs begin in cells called interstitial cells of Cajal (ICC), in the wall of the GI tract.