This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Physiology
Which of the following decreases appetite? 
Select and explain. 
A. Orexin, B. Neuropeptide Y, C. Ghrelin, D. Leptin
D: Leptin
Answer: D: Leptin 
Explanation: Food intake and appetite are regulated by various circulating hormones including ghrelin and glucagon-like-peptide 1 (GLP-1). Ghrelin, mainly released from the stomach, increases food intake, induces appetite, enhances adiposity as well as releases growth hormone Ref: guyton and hall textbook of medical physiology 12 edition page number:811,812,813