This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
In unconjugated hyperbilirubinemia, the risk of kernicterus increases with the use of – 
Select and explain. 
A. Ceftriaxone, B. Phenobarbitone, C. Ampicillin, D. Sulphonamide
D: Sulphonamide
Answer: D: Sulphonamide 
Explanation: The administration of sidfonamides to newborn infants, especially if premature, may lead to the displacement of Bilirubin from plasma albumin. In newborn infants, free Bilirubin can become deposited in the basal
subthalamic nuclei of the brain 'causing an encephalopathy called kernicterus. Sulfonamides should not be given to pregnant women near term because these drugs pass through the placenta and are secreted in milk.
Kernicterus is due to unconjugated hyperbilirubinemia.