This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Favourable prognosis for AML with ? 
Select and explain. 
A. t(8,21), B. Deletion 5q, C. Preceeding MDS, D. Age < 2years
A: t(8,21)
Answer: A: t(8,21) 
Explanation: Ans. 'a' i.e., t(8,21) Monsomies (eg. -5 or -7) carry poor prognosis. Prognostic factors of AML There are many prognostic factors for AML of paicular note are : - Age : - Age greater than 65 years or less than 2 years has been associated with poor prognosis independent of cytogenetics. AML evolving from prior myelodysplastic syndrome (MDS) is associated with poor prognosis. Leukocytosis and/or an elevated peripheral blast count are associated with poor prognosis. Cytogenetics : - AML prognosis is currently separated into three broad categories based on cytogenic results:- o Favourable : inv (16), t (15:17), t (8 : 21). Intermediate : Normal, + 8, + 21, +22, del (7q), del (9q), Abnormal 11 q23. Unorable : - -5, -7, complexes with 5 chromosomes involved, del (5q), abnormal 3q, abnormal 17p.