This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The following statements regarding insulin resistance in diabetic patients are true except: 
Select and explain. 
A. It is more common with huminsulin, B. It may occur in the presence of infections, C. It may be due to antibodies to insulin, D. Use of glucocorticoids may be useful in severe cases
A: It is more common with huminsulin
Answer: A: It is more common with huminsulin 
Explanation: Insulin resistance in diabetic patients has been deﬁned as insulin requirement of more than 2 U/kg/day for control of hyperglycemia or prevention of ketosis for more than 3 days in the absence of any complications. Stressful conditions (when there is excess of glucocorticoids and other hyperglycemic hormones) like trauma, surgery, and infections can oppose insulin action and  produce short-term insulin resistance. In few patients, it may be due to development of antibodies of the IgG type to minor contaminants or to some components (e.g. Zinc, protamine, etc.,) added to insulin, hence it is less commonly seen with purer preparations of insulin or with human insulin  (huminsulin). 
In case the resistance persists, a short-term course with prednisolone (immunosuppressant) may bring down the insulin requirement.