This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Gross hematuria can be seen in: 
Select and explain. 
A. IgA nephropathy, B. Sickle cell disease, C. Both IgA nephropathy and sickle cell disease, D. MPGN
C: Both IgA nephropathy and sickle cell disease
Answer: C: Both IgA nephropathy and sickle cell disease 
Explanation: Patients with glomerular disease have hematuria with proteinuria. Hematuria is asymptomatic. 3-5 red blood cells in the first-voided morning urine is suspicious. Patients will not realize the microscopic hematuria, and only rarely gross hematuria present The exceptions are IgA nephropathy and sickle cell disease in both gross hematuria present. Ref: Harrison-18, P-2336.