This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Drug causing hypercoagulability is - 
Select and explain. 
A. L-asparginase, B. Busulfan, C. Melphalan, D. 5-FU
A: L-asparginase
Answer: A: L-asparginase 
Explanation: Ans. is 'a' i.e., L-asparginase o The major toxicity of asparginase is clotting abnormalities (hypercoagulability or bleeding tendency). It may also cause pancreatitis, hyperglycemia and neurological toxicity.