This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
A 50-year-old male with a positive family history of prostate cancer has come to you for a screening test. The most sensitive screening test to pickup prostate cancer is: 
Select and explain. 
A. DRE, B. PSA, C. DRE + PSA, D. Endorectal Coil MRI with T1W and T2W images
C: DRE + PSA
Answer: C: DRE + PSA 
Explanation: Smith's Urology writes - "At the present time the data suggest that if screening is done, the combination of DRE & Serum PSA is best."
The diagnosis of Ca Prostate is established by TRUS-guided transrectal biopsy.