This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
High-altitude acclimatization may be facilitated by all except? 
Select and explain. 
A. Increased production of red blood cells, B. Increased alveolar ventilation, C. Growth of new blood vessels, D. Growth of new skeletal muscle fibers
D: Growth of new skeletal muscle fibers
Answer: D: Growth of new skeletal muscle fibers 
Explanation: Erythropoietin secretion increases promptly on ascent to high altitude and then falls somewhat over the following 4 days as the ventilatory response increases and the aerial PO2 rises. The increase in circulating red blood cells triggered by the erythropoietin begins in 2-3 days and is sustained as long as the individual remains at high altitude. Compensatory changes also occur in the tissues. The mitochondria, which are the site of oxidative reactions, increase in number, and myoglobin increases, which facilitates the movement of O2 into the tissues. The tissue content of cytochrome oxidase also increases.The natives who live in high altitudes are barrel-chested and markedly polycythemic. They have low alveolar PO2 values, but in most other ways they are remarkably normal. Ref: Barrett K.E., Barman S.M., Boitano S., Brooks H.L. (2012). Chapter 35. Gas Transpo & pH. In K.E. Barrett, S.M. Barman, S. Boitano, H.L. Brooks (Eds), Ganong's Review of Medical Physiology, 24e.