This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Verapamil is contraindicated in all, except ? 
Select and explain. 
A. PSVT with AV Block, B. Variant angina, C. Beta adrenergic toxicity, D. Digitalis toxicity
B: Variant angina
Answer: B: Variant angina 
Explanation: Ans. is 'b' i.e., Variant angina "All CCBs are effective in reducing frequency and severity of classical as well as variant angina". Due to these cardiodepressant effects, it is C/I in the following conditions. Sick sinus syndrome (causes cardiac arrest) A- V block (Accentuate conduction defects) Congestive hea failure Hypotensive states Ventricular tachycardias AF with accessory pathway or WPW syndrome. o Other conditions in which Verapamil is C/I. Digoxin toxicity ---> Increases plasma digoxin level by decreasing its excretion, toxicity can develop. Quinidine and disopyramide ---> Both these drugs have cardiac depressant action. Verapamil is not used with b blockers because their depressant effect on SA and AV node may add up. b