This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Lewis Triple Response is mediated by: 
Select and explain. 
A. Histamine, B. Axon reflex, C. Injury to endothelium, D. None of the above
A: Histamine
Answer: A: Histamine 
Explanation: Histamine is primarily responsible for Lewis Triple Response. Ref: Goodman and Gilman's Manual of Pharmacology and Therapeutics, 11th Edition, Page 405; Skin Immune System By Jan D. Bos, Pages 401-2; Ganong's Review of Medical Physiology, 22nd Edition, Pages 593, 625, 627; Basic and Clinical Pharmacology By Katzung, 25th Edition, Page 258