This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
All the following are the effects of oestrogen, EXCEPT: 
Select and explain. 
A. Beneficial effect on cognition, B. Reduced osteoclastic activity, C. Increased osteoblastic activity, D. Increased protein C and S levels
D: Increased protein C and S levels
Answer: D: Increased protein C and S levels 
Explanation: The effects of oestrogen on the skeletal system includes: 1) Increased osteoblastic activity 2) Reduced osteoclastic activity 3) Prevents osteoporosis 4) Promotes fusion of epiphyses Also know Oestrogen increases factor II, III, IX, X, XII and decreases protein C , S and antithrombin III. Ref: Essentials of Gynaecology by Lakshmi Seshadri, Edition 1, page - 44