This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulator, Subject name: Pharmacology
Etanercept is a biological disease-modifying agent used in the management of rheumatoid arthritis. Its mechanism of action is: 
Select and explain. 
A. TNF alpha blockade, B. COX-2 inhibition, C. IL-6 inhibition, D. Stabilization of mast cells
A: TNF alpha blockade
Answer: A: TNF alpha blockade 
Explanation: Ans. (A) TNF alpha blockade(Ref: KDT 8th/e p943)TNF alpha blocking drugs are used in rheumatoid arthritis and Crohn disease. These include*Adalimumab*Certolizumab*Etanercept*Infliximab*Golimumab