This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of protein and amino acid, Subject name: Biochemistry
Increased uric acid level in plasma is due to 
Select and explain. 
A. Increased purine utilization, B. Decreased purine synthesis, C. Decreased degradation purine, D. Decreased reutilization purine
D: Decreased reutilization purine
Answer: D: Decreased reutilization purine 
Explanation: Salvage pathway ensures the recycling of purines formed by the degradation of nucleotides.Some reactions will consume PRPP and produce more nucleotides will inhibit the enzymes thus salvage pathway is blocked.Ref: DM Vasudevan - Textbook of Biochemistry, 7th edition, page no: 567