This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anesthesia, Subject name: Pharmacology
Which anaesthetic modality is to be avoided in sickle cell disease? 
Select and explain. 
A. General Anaesthesia, B. Brachial Plexus Block, C. Intravenous Regional Anaesthesia, D. Spinal Anaesthesia
C: Intravenous Regional Anaesthesia
Answer: C: Intravenous Regional Anaesthesia 
Explanation: IV regional anaesthesia is useful for rapid anesthetization of an extremity (upper or lower). A rubber bandage is used to force the blood out of the limb and a tourniquet is applied to prevent the re-entry of blood.This causes risk of massive hemolysis due to low oxygen tension or hemolytic crisis due to low blood flow.All the other given methods above don&;t carry that risk.