This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
In unconjugated hyperbilirubinemia, the risk of kernicterus increases with the use of - 
Select and explain. 
A. Ceftriaxone, B. Phenobarbitone, C. Ampicillin, D. Sulphonamide
D: Sulphonamide
Answer: D: Sulphonamide 
Explanation: Ans. is 'd' i.e., Sulphonamide o Kernicterus may be precipitated in newborn, especially premautre, by displacement of bilirubin from plasma protein binding sites.