This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Oncology, Subject name: Medicine
True about malignant melanoma- 
Select and explain. 
A. Lymphatic spread, B. Lymph node biopsy is always done, C. Biopsy to be done when sentinel node is involved, D. Microsatellitism seen
A: Lymphatic spread
Answer: A: Lymphatic spread 
Explanation: The main cause of death in melanoma patients is widespread metastases. Metastases develop in regional lymph nodes, as satellite or in-transit lesions, or in distant organs. Lymph flow and chemotaxis is responsible for the homing of melanoma cells to different sites Ref Harrison 20th edition pg 556