This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
In apoptotic permeabilization of membrane occurs in 
Select and explain. 
A. Nuclear membrane, B. Pytoplasmic membrane, C. Lysosome, D. Mitochondrial membrane
D: Mitochondrial membrane
Answer: D: Mitochondrial membrane 
Explanation: Mitochondrial membrane ruptures releasing substances like cytochrome c ....which play major role in apoptosis Ref guyton and hall textbook of medical physiology 12/e pg 40