This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Pubey, Subject name: Pediatrics
In hypogonadotropic hypogonadism? 
Select and explain. 
A. Both LH and FSH decreased, B. Both LH and FSH increased, C. LH increased and FSH decreased, D. LH decreased and FSH increased
A: Both LH and FSH decreased
Answer: A: Both LH and FSH decreased 
Explanation: - LH and FSH are decreased in hypogonadotropic hypogonadism. Hypogonadotropic hypogonadism: - Reversible - if its d/t to Chronic systemic illness (CKD, Chronic liver Disease) Severe malnutrition Endocrine causes (hypothyroidism, type 1 DM) - Permanent if its d/t Isolated delayed pubey - Genetic mutations - KAL 1 (Kallmann Syndrome), GnRH Receptor, DAX -1 gene - Syndromes- Prader Willi Syndrome, Laurence Moon Syndrome MPHD (multiple pituitary hormone disease) - Injury - Infiltration by tumors- Langerhan cell histiocytosis - Genetic - PROP1,LH - Malformations - Trauma