This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
He is very likely has defect in which of the following mechanism 
Select and explain. 
A. Peptidyl transferase activity, B. Cut DNA at specific site, C. Paicipate in DNA synthesis, D. GTPase activity
A: Peptidyl transferase activity
Answer: A: Peptidyl transferase activity 
Explanation: Ans. a. Peptidyl transferase activityRibozymes are RNA molecule with catalytic activitydeg. Ribozymes play a central role in peptide bond formation (peptidyl transferase activity).RibozymeRibozymes are RNA molecules with catalytic activityo.These generally involve transesterification reactions, and most are concerned with RNA metabolism (splicing and endoribonuclease).Recently, a ribosomal RNA component was noted to hydrolyze an aminoacyl ester and thus play a central role in peptide bond formation (peptidyl transferase)Q