This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Thalassaemia major manifests in- 
Select and explain. 
A. Childhood, B. Pubey, C. Adolescence, D. Middle age
A: Childhood
Answer: A: Childhood 
Explanation: Ans. is 'a' i.e., Childhood o Severe anemia manifests 6-9 months after bih, as hemoglobin synthesis switches from HbF to HbA.