This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In the earliest stages of carious Lesion. There is loss of: 
Select and explain. 
A. Enamel cuticle, B. Interprismatic substance, C. Organic matrix, D. Enamel lamellae
B: Interprismatic substance
Answer: B: Interprismatic substance 
Explanation: None