This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Anatomy
In Wilms tumor the following leads to emergence of resistance to chromotherapy 
Select and explain. 
A. Nehprogenic rests, B. Monoblastic morphology, C. Anpalsia, D. Capsular infiltration
C: Anpalsia
Answer: C: Anpalsia 
Explanation: 5 percnt of tumors have Anpalsia, defined as the presence of cells with large hyperchromatic pleomprphic nuclei and abnormal mitosis and the presrnc of anapladsia coreltes with p53 mutation