This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
Most common cause of Papillary necrosis is 
Select and explain. 
A. Diabetes Mellitus, B. Sickle cell anaemia, C. Analgesics, D. Pyelonephritis
C: Analgesics
Answer: C: Analgesics 
Explanation: Major causes of Papillary Necrosis1. Analgesic nephropathy2. Sickle cell nephropathy3. Diabetes with UTI4. Prolonged NSAID use Reference: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 340; Tubulointerstitial Diseases of the Kidney