This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Furosemide should not be administered with NSAIDS because they: 
Select and explain. 
A. Inhibit prostacyclin synthesis, B. Prevent platelet aggregation, C. Decrease sodium reabsorption, D. Increase the secretion of furosemide in urine
A: Inhibit prostacyclin synthesis
Answer: A: Inhibit prostacyclin synthesis 
Explanation: Indomethacin and other NSAIDs diminish the action of high ceiling diuretics. Inhibition of PG synthesis in the kidney, through which furosemide and related drugs induce intrarenal haemodynamic changes which secondarily affect salt output, appears to be the mechanism. Antihypertensive action of thiazides and furosemide is also diminished by NSAIDs.