This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
In nephrotic syndrome the essential feature is ? 
Select and explain. 
A. Proteinuria, B. Hypoalbuminemia, C. Hyperlipemia, D. Edema
A: Proteinuria
Answer: A: Proteinuria 
Explanation: Ans. is 'a' i.e., Proteinuria o All the given options occur in nephrotic syndrome, but proteinuria is the most characteristic, which is the basic defect. o The underlying abnormality in nephrotic syndrome is an increase in permeability of the glomerular capillary wall, which leads to massive proteinuria and hypoalbuminemia.