This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET Jan 2020, Subject name: Biochemistry
Apolipoprotein B-48 made by? 
Select and explain. 
A. RNA alternat splicing, B. RNA editing, C. DNA editing, D. RNA interference
B: RNA editing
Answer: B: RNA editing 
Explanation: In liver cell, Apo B 100 gene gives rise to Apo B 100 protein. ButApo B 48 proteinis made inintestinal cellsfrom the gene encoding Apo B 100, by the process ofRNA editing, which is also known as Differential RNA processing or chemical modification of RNA. This is apost transcriptional modification. OTHER OPTIONS: OPTION A:RNA splicing is also a post transcriptional modification but this is removal of introns. OPTION D:RNA interference is silencing technique where the gene is silenced by not letting the product of gene formed. Translocation occurs during translation. This is movement of ribosome over mRNA.