This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Physiology
Initiating event of Endotoxic shock 
Select and explain. 
A. Endothelial injury, B. Peripheral vasodilata on, C. Cytokinin action, D. Decreased pumping of hea
C: Cytokinin action
Answer: C: Cytokinin action 
Explanation: The receptor for the endotoxin in humans is the TLR-4 located on the surface of antigen presenting cells. b. Binding to the receptor activates a cascade of enzymatic reactions which finally leads to the activation of the genes for the proinflammatory cytokines. Ref ganong's review of medical physiology 25e p465