This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
If cellular proteins do not fold into a specific conformation, their functions are affected. Ceain disorders arise, if specific proteins are misfolded. Which of the following disorders arises due to conformational isomerization? 
Select and explain. 
A. Familial fatal insomnia, B. Hepatitis delta, C. Pernicious anemia, D. Lesch-Nyhan syndrome
A: Familial fatal insomnia
Answer: A: Familial fatal insomnia 
Explanation: Familial fatal insomnia