This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
Familial hypercholesterolemia is due to defect in 
Select and explain. 
A. Apo A, B. Lipoprotein lipase, C. Apo C, D. Apo B 100
D: Apo B 100
Answer: D: Apo B 100 
Explanation: Name Defect Remarks Familial hypercholesterolemia (type IIa) Defective LDL receptors or mutation in the ligand region of apo B-100 Elevated LDL levels and hypercholesterolemia, resulting in atherosclerosis and coronary disease Reference: Harper; 30th edition; Page no: 275