This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
Primary hyperaldosteronism (Conn's syndrome) is characterized by- 
Select and explain. 
A. High renin, high aldosteorone, B. Low renin, high aldosterone, C. Low renin, low aldosterone, D. High renin, low aldosterone
B: Low renin, high aldosterone
Answer: B: Low renin, high aldosterone 
Explanation: high aldosterone and low renin because as there is hypo secretion of renin that fails to increase appropriately during volume depletion and hyper secretion of aldosterone that does not suppress in response to volume expansion (Harrison 17 pg 2260)