This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following can reverse one or more smooth muscle effects of circulating histamine in humans? 
Select and explain. 
A. Granisetron, B. Adrenaline, C. Ranitidine, D. Sumatriptan
B: Adrenaline
Answer: B: Adrenaline 
Explanation: Adrenaline is a physiological antagonist of histamine. It reverses bronchoconstriction caused by histamine. Ranitidine is an H2 antagonist that decreases gastric acid secretion but has no effect on smooth muscles.