This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy: General Principles, Subject name: Pharmacology
TRUE statement about penicillin G is: 
Select and explain. 
A. It is administered orally, B. It has a wide spectrum, C. It can be used for rat bite fever, D. Co-administration of probenecid decreases its duration of action
C: It can be used for rat bite fever
Answer: C: It can be used for rat bite fever 
Explanation: Ans. (C) It can be used for rat bite fever(Ref: KDT 8th/e p768-770)Penicillin GIt is acid labile, thus not effective orally.Penicillin G has short duration of action. Probenecid inhibits tubular secretion and prolongs its duration of action.It has narrow antibacterial spectrum, mainly for gram positive bacteria.Penicillin G is drug of choice for infections caused by Treponema like syphilis (T. pallidum) and Rat bite fever (Spirillum minus).