This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Wire loop thickening of glomerular basement membrane is seen in - 
Select and explain. 
A. Systemic lupus erythematosus (SLE), B. Non Insulin Dependent Diabetes Mellitus, C. Rapidly progressive glomerulonephritis, D. Malignant hypeension
A: Systemic lupus erythematosus (SLE)
Answer: A: Systemic lupus erythematosus (SLE) 
Explanation: Ans. is 'a' i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis.