This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Paradoxical response of GH release to TRH is seen in: 
Select and explain. 
A. Prolactinoma, B. Acromegaly, C. Malnutrition, D. Pituitary adenoma
B: Acromegaly
Answer: B: Acromegaly 
Explanation: Answer is B (Acromegaly): In patients with Acromegaly TRH can cause a paradoxical increase in GH secretion which is not observed in normal individuals. 'About 60% of patients with GH secreting tumors (Acromegaly) may exhibit paradoxical GH response to TRH administration'- Harrison 16th/2090