This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The development of resistance to conventional treatment has led WHO to recommned the use of combination therapies containing aemisinin derivative (aemisinin-based combination therapies also known as ACTs). All of the following combination therapies are recommended if such resistance is suspected, except - 
Select and explain. 
A. Aemether plus lumefantrine, B. Aesunate plus quinine, C. Aesunate plus pyrimethamine-sulfadoxine, D. Aesunate plus mefloquine
B: Aesunate plus quinine
Answer: B: Aesunate plus quinine 
Explanation: Ans. is 'b' i.e. Aesunate plus quinine The WHO recommended ACTs (aemisinin-based combination therapies) o Aemether + lumefantrine o Aesunate + sulfadoxine-pyrimethamine o Aesunate + amodiaquine o Aesunate + mefloquine o Dihydroaemisinin + piperaquine.