This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
Tangier disease is characterized by 
Select and explain. 
A. Low HDL, B. Defective LDL receptors, C. No chylomicrons, D. Overproduction of VLDL
A: Low HDL
Answer: A: Low HDL 
Explanation: DyslipoproteinemiasDefectRemarksFamilial alpha-lipoprotein deficiencyTangier diseaseFish-eye diseaseApo-A-I deficienciesAll have a low or near absence of HDLA tendency toward hyperiacylglycerolemia as a resultof the absence of apo C-ll, causing inactive LPL. Low LDLlevels. Atherosclerosis in the elderlyRef: Harper&;s biochemistry; 30th edition; Chapter 26; Cholesterol Synthesis, Transpo, & Excretion