This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Prion disease is caused by 
Select and explain. 
A. Misfolding of protein, B. Denaturation of Protein, C. Reduced formation of protein, D. Excess formation of protein
A: Misfolding of protein
Answer: A: Misfolding of protein 
Explanation: ref Robbins 9/e p1281 Prion diseases are caused by misfolded forms of the prion protein, also known as PrP. ... The human forms of prion disease are most often the names Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI), Gesmann-Straussler-Scheinker syndrome (GSS), kuru and variably protease-sensitive prionopathy (VPSPr