This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Renal carcinoma, Subject name: Pathology
True statements about renal cell carcinoma except? 
Select and explain. 
A. Asbestos, sickle cell anemia & petroleum products are risk factors, B. Clear cell cancer arise from proximal convoluted tubule, C. Cannon ball metastasis, D. Bellini duct cancer arise from loop of henle.
D: Bellini duct cancer arise from loop of henle.
Answer: D: Bellini duct cancer arise from loop of henle. 
Explanation: Bellini duct cancer arise from the collecting duct cells in medulla & not the Loop of Henle. Risk factors of Renal Cell Carcinoma : Cigarette smokers have double the incidence of renal cell carcinoma Tobacco HTN /obesity/estrogen Asbestos Sickle cell anemia Petroleum products Clear cell carcinoma arises from Proximal convoluted Tubule. Cannon ball opacities on chest x-ray suggest metastatic malignancies such as choriocarcinoma, lung carcinoma, renal cell cancer, or endometrial carcinoma.