This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Growth and development, Subject name: Pediatrics
Earliest sign of rickets is __________ 
Select and explain. 
A. Craniotabes, B. Harrisons groove, C. Rachitic rosary, D. Pigeon breast
A: Craniotabes
Answer: A: Craniotabes 
Explanation: Most manifestations of rickets are a result of skeletal changes , Craniotabes is a softening of the cranial bones and can be detected by applying pressure at the occiput or over the parietal bones. T he sensation is similar to the feel of pressing into a ping-pong ball and then releasing. Craniotabes may also be secondary to osteogenesis imperfecta, hydrocephalus, and syphilis. Ref.nelson 20th edition page 339 nutrition chapter