This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Sympathetic System, Subject name: Pharmacology
Alkalinization of urine is required to treat toxicity of all except: 
Select and explain. 
A. Salicylates, B. Barbiturates, C. Amphetamine, D. Methotrexate
C: Amphetamine
Answer: C: Amphetamine 
Explanation: Changes in urinary pH affect tubular reabsorption of drugs that are paially ionized - * Weak bases are ionize more and are less reabsorbed in acidic urine.* Weak acids ionize more and are less reabsorbed in alkaline urine. Urine is alkalinized in barbiturate, methotrexate and salicylate poisoning.