This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pediatric Ohopedics, Subject name: Orthopaedics
Mutation seen in Marfan syndrome: 
Select and explain. 
A. Fibrillin-1 gene, B. FGFR-3 gene, C. COL1A1, D. Fibrillin-2
A: Fibrillin-1 gene
Answer: A: Fibrillin-1 gene 
Explanation: Marfan Syndrome: Fibrillin 1 gene defect FGFR3- is seen in achondroplasia COL1A1- osteogenesis imperfecta Fibrillin2- Congenital contractural arachnodactyly (CCA) -phenotypically similar to Marfan syndrome