This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Single Gene Disorders, Subject name: Pathology
Which of the following is not a propey of autosomal dominant disorders? 
Select and explain. 
A. Affects males and females equally, B. Veical inheritance, C. Complete penetrance, D. Variable expressivity
C: Complete penetrance
Answer: C: Complete penetrance 
Explanation: Incomplete penetrance and not Complete penetrance is feature of autosomal dominant disorder. Autosomal dominant disorder: Heterozygosity expression 50% progeny are affected Veical inheritance (at least 1 affected member is seen in each generation) Affect both female and male equally Associated with involvement of structural protein Either they have loss of function mutation or gain of function mutation. Incomplete penetrance Variable expressivity (some affected individual have mild, some patient have moderate or severe disease).