This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
Leber's optic neuropathy- 
Select and explain. 
A. Typically presents in the fourth decade of life, B. Males do not transmit the disease, C. Is inherited in autosomal X-link fashion, D. The optic disc is pale early in the disease
B: Males do not transmit the disease
Answer: B: Males do not transmit the disease 
Explanation: Leber's hereditary optic neuropathy is a mitochondrial disorder. Since mitochondrial DNA is exclusively derived from mothers, males do not transmit the disease.
The optic disc becomes pale and atrophic in late atrophic phase (not early).