This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Rofecoxib as compared to indomethacin is : 
Select and explain. 
A. Less likely to cause gastric ulcer and their complications, B. Likely to be more effective in rheumatoid arthritis, C. Not likely to produce renal complications, D. All of the above
A: Less likely to cause gastric ulcer and their complications
Answer: A: Less likely to cause gastric ulcer and their complications 
Explanation: Selective COX-2 inhibitors are less likely to cause GI complications like PUD. However a COX-2 is also present constitutively in the kidney, chances of renal complications are similar. These drugs have similar or less efficacy than non-selective COX inhibitors.