This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Protein Synthesis Inhibitors, Subject name: Pharmacology
Hepatitis with cholestatic jaundice occurs most frequently as an adverse reaction to the following preparation of erythromycin: 
Select and explain. 
A. Erythromycin base, B. Erythromycin stearate, C. Erythromycin estolate, D. Erythromycin ethyl succinate
C: Erythromycin estolate
Answer: C: Erythromycin estolate 
Explanation: Erythromycin estolate is responsible for cholestatic jaundice. It stas after 2-3 weeks of staing treatment. Symptoms include nausea, vomiting and cramping pain in abdomen. Risk of this adverse effect increases significantly in pregnancy. Therefore, erythromycin estolate is contra-indicated in pregnancy.