This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Early manifestation of a patient infected with HIV virus is: 
Select and explain. 
A. Elevation of p16, B. Unexplained fear and weight loss, C. Kaposi's sarcoma, D. Hairy cell leukoplakia
B: Unexplained fear and weight loss
Answer: B: Unexplained fear and weight loss 
Explanation: None