This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
PNH is associated with a deficiency of - 
Select and explain. 
A. DAF, B. MIRL, C. GPI anchored protein, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: PNH is a disease that results from acquired mutation in PIGA an enzyme that is essential for the synthesis of ceain membrane associated complement regulatory proteins. PNH blood cells are deficient in 3 GPI linked proteins that regulate compliment activity. 1. Decay accelerating factor (DAF) or CD55 Membrane inhibitor of reactive lysis or CD59 (MIRL) 3 C8 binding protein Ref: Robbins and Cotran Pathologic basis of disease.South Asia Edition volume 1 ; 9th edition.page no.642