This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
Tamm-Horsfall protein is secreted by epithelial cells of 
Select and explain. 
A. Proximal convoluted tubule, B. Loop of Henle, C. Distal convoluted tubule, D. Glomerulus
B: Loop of Henle
Answer: B: Loop of Henle 
Explanation: Tamm-Horsfall protein or uromodulin, the most common protein in urine and produced in the thick ascending limb of the loop of Henle AKI can be induced by mechanical obstruction of the distal nephron lumen when myoglobin or haemoglobin precipitates with Tamm-Horsfall protein Myeloma light chains can also cause AKI by direct tubular toxicity and by binding to Tamm-Horsfall protein to form obstructing intratubular casts. Ref: Harrison 19e 1804