This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Zellweger syndrome is due to 
Select and explain. 
A. Absence of peroxisome, B. Absence of cytochrome, C. Absence of COX, D. Absence of LOX
A: Absence of peroxisome
Answer: A: Absence of peroxisome 
Explanation: Zellweger syndrome is due to absence of peroxisomes in all most all tissues, as a result of which long chain fatty acids are not oxidized and accumulated in live and brain. So this syndrome is also called as cerebrohepatorenal syndrome.