This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General surgery, Subject name: Surgery
All are genetic conditions with increased risk of malignancy except 
Select and explain. 
A. Gorlin's syndrome, B. Xeroderma pigmentosum, C. Ferguson-Smith syndrome, D. Neurofibromatosis
D: Neurofibromatosis
Answer: D: Neurofibromatosis 
Explanation: Neurofibromatosis is associated the development of smooth surfaced cafe-au-lait spots, subcutaneous neurofibromata, armpit or groin freckling and Lisch nodulesNaevoid basal cell carcinoma (Gorlin's) syndromeThis is an autosomal dominant inherited condition caused by an abnormal tumour suppressor gene on Ch. 9q 22-31 coding the 'patched' protein. 90% of patients develop multiple basal cell carcinomas (BCCs).Xeroderma pigmentosumThis syndrome is caused by an abnormality on the 'patched' gene of Ch. 9q resulting in aberrant nucleotide repair during cellular DNA maintenance.>2000-fold increase in skin cancer risk Autosomal recessive inheritanceFerguson-Smith syndromeThis is a rare, autosomal-dominantly inherited abnormality on Ch. 9q Affected individuals develop multiple self-healing squamous cell carcinomas (SCC).Ref: Bailey and Love, 27e, page: 595