This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Trisomy 21 is associated with: September 2008 
Select and explain. 
A. ALL, B. AML, C. Both of the above, D. None of the above
C: Both of the above
Answer: C: Both of the above 
Explanation: Ans. C: Both of the aboveChildren with trisomy 21 have a 10-20 fold increased risk of developing acute leukemia.Both AML and ALL can occur.AML, most commonly, is acute megakaryoblastic leukemia.