This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
Hirschsprung&;s disease is due to 
Select and explain. 
A. Loss of ganglion cells in the sympathetic chain, B. Atrophy of longitudinal muscles, C. Failure of migration of neural crest cells from cranial to caudal direction, D. Malformed teania coli
C: Failure of migration of neural crest cells from cranial to caudal direction
Answer: C: Failure of migration of neural crest cells from cranial to caudal direction 
Explanation: .* It is a congenital, familial condition, occurring in newborn due to the absence of ganglion cells-- Auerbach's and Meissner's plexus in anorectum, which may extend proximally either a pa or full length of the colon. ref:SRB&;s manual of surgery,ed 3,pg no 818