This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
In a child admitted with H. Influenza meningitis, Cefotaxime was staed instead of ampicillin. Which of these is the likely reason for this? 
Select and explain. 
A. H. influenzae stains known to produce Beta lactamase, B. H. influenzae stains known to have altered penicillin binding protein, C. More easier to give, D. It is cheap
A: H. influenzae stains known to produce Beta lactamase
Answer: A: H. influenzae stains known to produce Beta lactamase 
Explanation: Ans. (a) H. influenzae stains known to produce Beta lactamase Approximately 20-35% of nontypable strains of hemophilus produce 13-lactamase. In addition to 0-lactamase alteration of penicillin binding proteins is a second mechanism of ampicillin resistance has been detected in isolates of H. influenzae.