This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
Familial polysosis coli is associated with 
Select and explain. 
A. Intussusception, B. Toxic magacolon, C. Cancer, D. Ulcerative colitis
C: Cancer
Answer: C: Cancer 
Explanation: .HNCC (hereditary nonpolyposis colonic cancer) * No polyps. Autosomal dominant* Three members of the family have colonic cancers * Lynch syndrome I is site specific - commonly right sided, occurs in early age group, 40% are metachronous * Lynch syndrome II has other malignancy in, stomach, breast, ovary, endometrium and urinary bladder. It is cancer family syndrome * Microsatellite instability (MSI) at DNA level occurs in HNCC * Accounts for 3-5% of colonic cancers * Amsterdam criteria I (1990); Amsterdam criteria II (1999) and revised Bethesda guidelines (2002) are used to diagnose HNCC ref:SRB&;S manual of surgery,ed 3,pg no 835