This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Medicine
An asymptomatic patient on regular health checkup has platelet counts of 8,00,000/cu.mm. Next line of management is: 
Select and explain. 
A. Follow up and observe, B. Bone marrow biopsy, C. Plasmapheresis, D. Phelobotomy
A: Follow up and observe
Answer: A: Follow up and observe 
Explanation: Normal platelet count =1.5 - 4.5 lac per cu.mm 35% of patients with thrombocytosis eventually end up being Diagnosed with Malignancy Causes of Thrombocytosis Tissue inflammation: collagen vascular disease, inflammatory bowel disease Hemorrhage Malignancy Iron-deficiency anemia Infection Surgery Myeloproliferative disorder: polycythemia Vera, primary myelofibrosis, chronic myelogenous leukemia Rebound: Correction of vitamin B12 or folate deficiency, post-ethanol abuse Myelodysplastic disorder: 5q- syndrome, idiopathic refractory sideroblastic anemia Hemolysis Post splenectomy or hypersplenism Familial: Thrombopoietin overproduction, JAK21 or MPL mutations