This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which of the following conditions is associated with Coomb's positive hemolytic anaemia: 
Select and explain. 
A. Thrombotic thrombocytopenic purpura, B. Progressive systemic sclerosis, C. Systemic lupus erythematosus, D. Polyaeritis nodosa
C: Systemic lupus erythematosus
Answer: C: Systemic lupus erythematosus 
Explanation: Answer is C (systemic lupus erythematosis) Coomb's positive hemolytic anemia is a feature of autoimmune vascular disease and may also be seen in SLE and other Collagen Vascular diseases including PAN and Systemic sclerosis. However amongst the options provided coombs positive hemolytic anemia is most commonly associated with SLE which is the single best answer of exclusion. Autoimmune hemoletic anemias are associated with 'collagen vascular diseases especially systemic lupus Erythematosis'- Harrisons Autoimmune hemolytic anemia are associated with 'autoimmune diseases paicularly Systemic Lupus Erythematosis' -Hoffman.