This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Beta galactosidase deficiency causes? 
Select and explain. 
A. Goucher disease, B. Krabbe's disease, C. Fabry's disease, D. Neimann Pick disease
B: Krabbe's disease
Answer: B: Krabbe's disease 
Explanation: Ans. is 'b' i.e., Krabbe's disease Krabbe disease, also known as globoid cell leukodystrophy or galactosylceramide lipidosis, is an autosomal-recessive sphingolipidosis caused by deficient activity of the lysosomal hydrolase galactosylceramide beta-galactosidase (GALC).GALC degrades galactosylceramide, a major component of myelin, and other terminal beta-galactose-containing sphingolipids, including psychosine (galactosylsphingosine).Beta-galactosidase is a lysosomal enzyme responsible for catalyzing the hydrolysis of gangliosides. The deficiency of this enzyme can lead to 1 of the following conditions: GM1 gangliosidosis, Morquio syndrome B, and galactosialidosis.