This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory system, Subject name: Physiology
Chloride shift is due to 
Select and explain. 
A. Generationof HCO3 in RBC's, B. Metabolism of glucoses in RBC's, C. Formation of O2-Hb complex in RBC's, D. Release of K in RBC's
A: Generationof HCO3 in RBC's
Answer: A: Generationof HCO3 in RBC's 
Explanation: Chloride shift (also known as the Hamburger phenomenon or lineas phenomenon, named after Haog Jakob Hamburger) is a process which occurs in a cardiovascular system and refers to the exchange of bicarbonate (HCO3-) and chloride (Cl-) across the membrane of red blood cells (RBCs Ref: guyton and hall textbook of medical physiology 12 edition page number:360,361,362