This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which interleukin is associated with fever and inflammation? 
Select and explain. 
A. Interleukin 1, B. Interleukin 12, C. Interleukin 5, D. Interleukin 2
A: Interleukin 1
Answer: A: Interleukin 1 
Explanation: IL-1 is the most important cytokine responsible for the systemic effects of inflammation.
IL-1, IL-6, TNF α and  type 1 interferons contribute to acute phase response.