This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
NSAIDS cause gastric ulcer because- 
Select and explain. 
A. They inhibit COX - 2 enzyme, B. They inhibit mucus production, C. They increase HCI production, D. They delay gastric emptying
B: They inhibit mucus production
Answer: B: They inhibit mucus production 
Explanation: Ans. is 'b' i.e., They inhibit mucus production o Normally, gastric mucosal PGs are produced by COX - 1. o Prostaglandins function as natural ulcer protectives by enhancing gastric mucus and HCO3- production, as well as by improving mucosal circulation and health. The ulcerogenic action of NSAIDs may be due to loss of this protective influence. o PGE analogues are cytoprotective at low doses and inhibit gastric acid secretion at higher doses. NSAIDs inhibit prostaglandin secretion and thus antagonizes its cytoprotective effect. o Misoprostol is used in NSAIDs induced ulcers.