This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Rate of newly synthesized osteoid mineralization can be best estimated by: 
Select and explain. 
A. Tetracycline labeling, B. Alizarin Red stain, C. Calcein stain, D. Von kossa stain
A: Tetracycline labeling
Answer: A: Tetracycline labeling 
Explanation: Tetracycline labeling is a type of bone label study used to estimate rate of newly synthesized osteoid mineralization. It is most commonly and widely used method. Ref: 'Target Organ Pathology' By Hooson, (1997), Page 270; Harrison's Principles of Internal Medicine, 16th Edition, Page 2223; Bone Research Protocols, (2003), Page 305