This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Wof sulfonylureas is used in treatment of neurogenic diabetes Insipidus 
Select and explain. 
A. Nateglinide, B. Tolbutamide, C. Chlorpropamide, D. Glipizide
C: Chlorpropamide
Answer: C: Chlorpropamide 
Explanation: Chlorpropamide:- is one of the first SUs which has been discontinued because of long duration of action (> 2 days) and frequent hypoglycaemia. Side effects:- It was also prone to cause dilutional hyponatraemia (by sensitizing kidney to ADH action- used in treating central DI), cholestatic jaundice and alcohol flush(disulfiram like reaction). Ref:- kd tripathi; pg num:-273