This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autoimmune Diseases, Subject name: Pathology
CANCA is associated with - 
Select and explain. 
A. Wegener's granulomatosis, B. Microscopic poly angitis, C. Chrug strauss syndrome, D. Good pasture syndrome
A: Wegener's granulomatosis
Answer: A: Wegener's granulomatosis 
Explanation: Ans. is 'a' i.e., Wegener's granulomatosisANCACytoplasmic staining (c-ANCA)Perinuclear staining (p-ANCA)Antigen here is proteinase-3Seen in conditions likeo Wegener's granulomatosisAntigen is myeloperoxidase (MPO) Seen in conditions likeo Microscopic poiyangitiso Churg-Strauss syndromeo Goodpasture's syndromeo Crescentic glomerulonephritiso Ulcerative colitiso Primaiy selerasing cholangitiso Drugs (hydralazine, propvthiouracil