This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Physiology
Anti-inflammatory action of steroids due to 
Select and explain. 
A. Inhibiton of phospholipase A2, B. Inhibhition of cyclooxegenase, C. Increased activity of lipolipase, D. Inhibition of lipo oxegenase
A: Inhibiton of phospholipase A2
Answer: A: Inhibiton of phospholipase A2 
Explanation: PLA2 has been shown to promote inflammation in mammals by catalyzing the first step of the arachidonic acid pathway by breaking down phospholipids, resulting in the formation of fatty acids including arachidonic acid. This arachidonic acid is then metabolized to form several inflammatory and thrombogenic molecules. Excess levels ofsPLA2 is thought to contribute to several inflammatory diseases.Ref: Ganong&;s review of medical physiology; 24th edition