This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Physiology
Binding of oxygen to haemoglobin reduces its affinity for carbon dioxide, which is known as 
Select and explain. 
A. Haldane effect, B. Chloride shift, C. Bohr effect, D. Anion exchanger 1
A: Haldane effect
Answer: A: Haldane effect 
Explanation: Increase in carbon dioxide in the blood causes oxygento be displaced from the hemoglobin (the Bohr effect). The reverse is also true: binding of oxygen with hemoglobin tends to displace carbon dioxidefrom the blood. Indeed, this effect, called the Haldane effect, Ref: Guyton & Hall: Textbook of Medical Physiology page no:946