This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Which of the following is activated by the binding of chemotactic agents to leukocyte membrane receptors? 
Select and explain. 
A. Leukotriene B 4, B. Histamine, C. Phospholipase C, D. Tumor necrosis factor
C: Phospholipase C
Answer: C: Phospholipase C 
Explanation: Phospholipase C The binding of chemotactic agents to receptors on leukocyte cell membranes causes activation of phospholipase C. A hydrolysis reaction ensues resulting in the release of calcium from intracellular stores. The increased cytosolic calcium is impoant in the movement of the cells in chemotaxis.