This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Tadpole cells comma shaped cells on histopathology are seen in - 
Select and explain. 
A. Trichoepithelioma, B. Spideroma, C. Rhabdomyosarcoma, D. Histiocytoma
C: Rhabdomyosarcoma
Answer: C: Rhabdomyosarcoma 
Explanation: Ans. is 'c' i.e., Rhabdomyosarcoma Histology of rhabdomvosarcoma o The diagnostic cell of rhabdomyosarcoma is rhabdomyoblast. o Rhabdomyoblast contains eccentric eosinophilic granular cytoplasm rich in thick and thin filaments. o The rhabdomyoblasts may be ? i) Round Elongated Tadpole or Strap cells. o It has three variants i) Embryonal Alveolar iii) Pleomorphic o Rhabdomyoblasts are positive for desmin, MYOD1 and Myogenin.