This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Adverse Drug Effect, Subject name: Pharmacology
chronic use of which drug is most likely to cause osteoporosis: 
Select and explain. 
A. Lovastatin, B. Propranolol, C. Warfarin, D. Corticosteroid
D: Corticosteroid
Answer: D: Corticosteroid 
Explanation: Ans. D. CorticosteroidCorticosteroids antagonize the action of 1, 25 dihroxy vitamin D3 and result in loss of calcium from the kidney. Also they cause resorption of bone thus leading to osteoporosis.