This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary Tract, Subject name: Pediatrics
True about minimal change disease is: 
Select and explain. 
A. Peak incidence is between 2-4 years of age, B. Renal failure is usually present in adolescent, C. Steroids are not effective medications for treatment., D. It is characterized by selective proteinuria
A: Peak incidence is between 2-4 years of age
Answer: A: Peak incidence is between 2-4 years of age 
Explanation: Ans. A. Peak incidence is between 2- 4 years of ageIn minimal change nephrotic syndrome (MCNS) (approximately 80% of total cases of nephrotic syndrome in children), the glomeruli appear normal or show a minimal increase in mesangial cells and matrix.Findings on immunofluorescence microscopy are typically negative, and electron microscopy simply reveals effacement of the epithelial cell foot processes. More than 95% of children with minimal change disease respond to corticosteroid therapy.A diagnosis other than MCNS should be considered in children <1 yr of age, with a positive family history of nephrotic syndrome, and/or the presence of extrarenal findings (e.g., arthritis, rash, anemia), hypertension or pulmonary edema, acute or chronic renal insufficiency, and gross hematuria.