This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
Glyceryl trinitrate is given by sublingual because of 
Select and explain. 
A. Sho t1/2 in plasma, B. High hepatic first pass metabolism, C. High bioavailability by oral route, D. Extensive protein binding
B: High hepatic first pass metabolism
Answer: B: High hepatic first pass metabolism 
Explanation: Refer kDT 6/e p 7 Main advantage of Sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation