This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Drugs in Pregnancy, Subject name: Gynaecology & Obstetrics
In terms of bih defect potential, the safest of the following drugs is 
Select and explain. 
A. Alcohol, B. Isotretinoin (Accutane), C. Tetracyclines, D. Progesterones
D: Progesterones
Answer: D: Progesterones 
Explanation: Alcohol sequelae include retardation of intrauterine growth, craniofacial abnormalities, and mental retardation. Isotretinoin, a drug for acne, is asoociated with congenital anomalies like Microtia, Micrognathia, cleft palate, thymic aplasia, CVS anomalies, NTDs Tetracyclines interfere with development of bone and can lead to stained teeth in children. Regarding progesterones use in pregnancy, controlled studies have failed to demonstrate a significant association with increased risk.