This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
Lid retraction is caused by 
Select and explain. 
A. Bimatoprost, B. Lantanoprost, C. Brimonidine, D. Apraclonidine
D: Apraclonidine
Answer: D: Apraclonidine 
Explanation: Apraclonidine is sympathomimetic agent used in open angle glaucoma. It decreases aqueous secretion. It can result in upper lid retraction as an adverse effect It can also result in ocular allergy( less likely with brimonidine) Both apraclonidine and brimonidine can cause CNS depression and Apnea in neonates under contraindicated in the children less than 2 years of age Refer drug facts and comparisons 2006/2257