This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
Organophosphates bind to 
Select and explain. 
A. Anionic site of AChEs, B. Esteratic site of AChEs, C. Ach, D. None
B: Esteratic site of AChEs
Answer: B: Esteratic site of AChEs 
Explanation: (Ref: KDT 6/e p99-100) The active region of Acetylcholinesterase (AChE) has two sites i.e. an anionic site and an esteratic site. Anticholinesterase poisoning like Organophosphate compounds binds to esteratic site of AChE.