This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation & Repair, Subject name: Pathology
A 77-year-old woman experiences a sudden loss of consciousness, with loss of movement on the right side of the body. Cerebral angiography shows an occlusion of the left middle cerebral artery. Elaboration of which of the following mediators will be most beneficial in preventing further ischemic injury to her cerebral cortex? 
Select and explain. 
A. Bradykinin, B. Leukotriene E4, C. Nitric oxide, D. Platelet-activating factor
C: Nitric oxide
Answer: C: Nitric oxide 
Explanation: Endothelial cells can release nitric oxide to promote vasodilation in areas of ischemic injury. Bradykinin mainly increases vascular permeability and produces pain. Leukotriene E4 , platelet-activating factor, and thromboxane A2 have vasoconstrictive properties.