This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
Mucopolysaccharidoses are caused by 
Select and explain. 
A. An increased rate of synthesis of proteoglycans, B. Defects in the degradation of proteoglycans, C. The synthesis of polysaccharides with an altered structure, D. An insufficient amount of proteolytic enzymes
B: Defects in the degradation of proteoglycans
Answer: B: Defects in the degradation of proteoglycans 
Explanation: Mucopolysaccharides are excreted in urine in abnormal amounts in the group of lysosomal storage disorders known as mucopolysaccharidoses. They can be detected by 2D gel electrophoresis techniques; some mucopolysaccharides can also be detected by simple urine screening tests like CPC test, Cetavlon test and Alcian blue staining.Ref: D M Vasudevan 7th edition Page no: 80