This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
ADAMS 13 mutation is responsible for: 
Select and explain. 
A. TTP, B. HUS, C. DIC, D. ITP
A: TTP
Answer: A: TTP 
Explanation: The pathogenesis of inherited or idiopathic TTP is related to the deficiency or antibodies to the metalloprotease ADAMTS13 that cleaves the vWF. Ref: Harrison, Edition-18, Page - 965