This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Biochemistry
Mark the false statement among given options related to heme : 
Select and explain. 
A. Glycine is required in 1st step of heme synthesis, B. Heme oxygenase produces CO2 , Fe3+ & water, C. Pyridoxal phosphate is required for the synthesis of d-amino levulinic acid, D. Cu is a constituent of ALA synthase
B: Heme oxygenase produces CO2 , Fe3+ & water
Answer: B: Heme oxygenase produces CO2 , Fe3+ & water 
Explanation: Synthesis of heme:* In first step of heme synthesis, Glycine amino acid is required* Glycine condenses with succinyl CoA to form 6-amino levulinate which serves as a precursor for heme synthesis. Heme oxygenase uses oxygen & it produces CO, Fe3+ & water. But it does not produce CO2. Copper is necessary for the synthesis of haemoglobin because Cu is a constituent of ALA synthase, needed for heme synthesis. Pyridoxal phosphate is required for the synthesis of d-amino levulinic acid, the precursor for heme. Extra Information Senescent RBCs are destroyed in reticuloendothelial System (RES) releasing hemoglobin Globin pa enters the amino acid pool Heme iron is usually oxidised to ferric iron forming hemin Hemin is the substrate of microsomal Heme Oxygenase system.