This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
For Ca breast best chemotherapeutic regimen 
Select and explain. 
A. Cyclophosphamide, methotrexate, 5-fluorouracil, B. Methotrexate, cisplatin, C. Cisplatin, adriamycin, steroid, D. Methotrexate, adriamycin, steroid
A: Cyclophosphamide, methotrexate, 5-fluorouracil
Answer: A: Cyclophosphamide, methotrexate, 5-fluorouracil 
Explanation: Chemotherapy using first generation regime such as 6-monthly cycle of cyclophosphamide, methotrexate and 5- fluorouracil(CMF) will achieve a 25% reduction in the risk of relapse over a 10-15 year peroid. Reference: Bailey and Love, 27th Edition, page no : 878.