This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Acetaminophen poisoning causes which of the following changes in the liver? 
Select and explain. 
A. Centrilobular necrosis in liver, B. Microvesicular fatty infiltration in hepatocytes, C. Cholestasis, D. Peripoal inflammation
A: Centrilobular necrosis in liver
Answer: A: Centrilobular necrosis in liver 
Explanation: Acetaminophen poisoning typically causes centrilobular necrosis in liver. Ref: Harrison's Principles of Internal Medicine, 18th Edition, Page 2560, see Table: 305-1.