This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Proteins and Amino Acids, Subject name: Biochemistry
Defect in folding of the protein result in which of the following clinical disease:- 
Select and explain. 
A. Kuru, B. Migraine, C. Hypothyroidism, D. Myopia
A: Kuru
Answer: A: Kuru 
Explanation: Ans. is 'a' Kuru .Prion diseases are known to occur because of defect in the secondary-tertiary protein structure (due to defect of folding of the peptide chain).Kuru is a prion disease.Other prion diseases are:Creutzfeldt-Jakob disease*Scrapie* (in sheep).Bovine spongiform encephalopathy* (in cattle).Note:Prion stands for proteinaceous infectious particle*.It contains no nucleic acid*.