This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S., Subject name: Medicine
What is the line of treatment for intractable Sydenham chorea? 
Select and explain. 
A. Haloperidol, B. Valproate, C. Warfarin, D. Risperidone
B: Valproate
Answer: B: Valproate 
Explanation: Ans. b. ValproateRef: Inflammatory and Autoimmune Disorders of the Nervous System in Children by Russell; Page No- 130Sydenham chorea remains the most common cause of acute chorea in children world-wide.It has been firmly established that Sydenham chorea is a complex neuropsychiatric condition, encompassing motor, sensory, and behavioural abnormalities.Although Sydenham chorea is an immune-mediated complication of streptococcus infection, details of its pathogenesis remain to beelucidated.Treatment with Valproic acid, neuroleptics, or, in selected cases, corticosteroids, is effective in the majority cases.