This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Mitochondrial chromosomal abnormaity leads to ? 
Select and explain. 
A. Lebers hereditary optic neuropathy, B. Angelman syndrome, C. Prader villi syndrome, D. Myotonic dystrophy
A: Lebers hereditary optic neuropathy
Answer: A: Lebers hereditary optic neuropathy 
Explanation: Ans. is 'a' i.e., Lebers hereditary optic neuropathy o Diseases associated with mitochondrial inheritance are rare and many of them affect the neuromuscular system. o Leber hereditary optic neuropathy is a prototype of this disorder. It is a neurodegenerative disease that manifests itself as progressive bilateral loss of central vision. Visual impairment is first noted between ages 15 and 35, and it leads to blindness. Cardiac conduction defects & minor neurologic manifestations have also been seen in some families.