This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Prophylaxis of a neonate born to a HBsAg positive mother should include: 
Select and explain. 
A. Vaccine, B. Immunoglobulins, C. Both Vaccine and Immunoglobulin, D. No active treatment required
C: Both Vaccine and Immunoglobulin
Answer: C: Both Vaccine and Immunoglobulin 
Explanation: Infants born to HBsAg positive mothers should receive both HBIG and HB vaccine IM at separate sites within 12 hours of bih followed by 2nd and 3rd doses of vaccine at 1 and 6 months respectively. Ref: Harrison's Internal Medicine, 17th Edition, Page 1948; Essential Pediatrics By O P Ghai, 6th Edition, Page 216