This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
Which fibrinolytic agent selectively activate fibrin bound plasminogen rather than circulating plasminogen 
Select and explain. 
A. Streptokinase, B. Urokinase, C. Alteplase, D. Both 'A' and 'C'
C: Alteplase
Answer: C: Alteplase 
Explanation: FIBRINOLYTICS (Thrombolytics) Alteplase It is moderately specific for fibrin bound plasminogen, so that circulating fibrinogen is lowered only by ~ 50%. It is rapidly cleared by liver and inactivated by plasminogen activator inhibitor-1 (PAI-1). The plasma t 1/2 is 4-8 min. Because of the sho t 1/2 , it needs to be given by slow i.v. infusion and often requires heparin co-administration. It is nonantigenic, but nausea, mild hypotension and fever. Ref:- kd tripathi; pg num:-627