This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
In the investigation of a patient with suspected essential thrombocythaemia, in which of the following genes may you find abnormalities? 
Select and explain. 
A. BCL-2, B. BCR, C. c-MYC, D. CAL-R
D: CAL-R
Answer: D: CAL-R 
Explanation: All of these mutated genes are associated with haematological conditions : BCR with chronic myeloid leukaemia (CML), c-MYC and BCL-2 with lymphoma, and MYH-9 with congenital thrombocytopathy. Only CAL-R, calreticulin, is associated with the myeloproliferative neoplasm essential thrombocythaemia.