This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Alkalinity of urine is done in - 
Select and explain. 
A. Barbiturate poisoning, B. Lithium toxicity, C. Alprazolam overdose, D. Diazepam toxicity
A: Barbiturate poisoning
Answer: A: Barbiturate poisoning 
Explanation: Ans. is 'a' i.e., Barbiturate poisoning Alkanization of urine o Acidic drugs are more ionized (lipid insoluble / polar / water soluble) at alkaline pH. So, they cannot be absorbed from tubular lumen, i.e. their excretion by kidney is enhanced by alkanization of urine. Such acidic drugs are Barbiturates and Salicylate. o Alkanization of urine is done by i.v. infusion of sodium bicarbonate.