This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
Cogan Syndrome is associated with all Except 
Select and explain. 
A. Splenomegaly, B. Interstitial keratitis, C. Vestibuloauditory symptoms, D. Aoic valvular insufficiency
A: Splenomegaly
Answer: A: Splenomegaly 
Explanation: Cogan's syndrome is characterized by interstitial keratitis together with vestibulo-auditory symptoms. It may be associated with a systemic vasculitis, paicularly aoitis with the involvement of the aoic valve. Glucocoicoids are the mainstay of treatment. Initiation of treatment as early as possible after the onset of hearing loss improves the likelihood of a orable outcome.Ref: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 385 The Vasculitis Syndromes; Page no: 2193