This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
All of the following are centrally acting antihypeensive drugs except:- 
Select and explain. 
A. Alpha methyl dopa, B. Clonidine, C. Guanabenz, D. Trimethoprim
D: Trimethoprim
Answer: D: Trimethoprim 
Explanation: Stimulation of a2 receptors in CNS leads to decrease in sympathetic outflow Therefore, a2 agonists can decrease the sympathetic activity and are useful for the treatment of hypeension. These include: Clonidine a-methyl dopa Guanafacine Guanabenz