This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Gastric carcinoma is associated with all of the following, except? 
Select and explain. 
A. Inactivation of p53, B. Over expression of C-erb, C. Over expression of C-met, D. Activation of RAS
B: Over expression of C-erb
Answer: B: Over expression of C-erb 
Explanation: Mutated p53 isoforms can generate an autoimmune response. Serum anti-p53 antibodies can serve as a diagnostic and prognostic marker in gastric cancer patients.Amplification of the c-met gene has been demonstrated in scirrhous-type gastric cancers. c-met is overexpressed or amplified in advanced gastric cancers of both the well-differentiated and poorly differentiated types.Ras activation is associated with the development of gastric cancer, but it is rare.