This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
Many signaling pathways involve the generation of inositol trisphosphate (IP3) and diacylglycerol (DAG). These molecules 
Select and explain. 
A. Are first messengers, B. Activate phospholipase C, C. Are derived from PIP2, D. Can't activate calcium calmodulin-dependent protein kinases directly or indirectly
C: Are derived from PIP2
Answer: C: Are derived from PIP2 
Explanation: IP3 DAG are secondary messengers derived from PIP2 they are present in the cell membrane where IP2 crosses the cell membrane and DAG doesnot. Ref: KD Tripathi 8th ed.