This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
True statement regarding first order kinetics is: 
Select and explain. 
A. Rate of elimination is independent of plasma concentration, B. A constant proportion of plasma concentration is eliminated per unit time, C. Half life increases with dose, D. Clearance decreases with dose
B: A constant proportion of plasma concentration is eliminated per unit time
Answer: B: A constant proportion of plasma concentration is eliminated per unit time 
Explanation: Ans. (B) A constant proportion of plasma concentration is eliminated per unit time(Ref: RID 8th/e p38-39)In first order kinetics, rate of elimination is proportional to plasma concentration of the drug. Half life and clearance are constant in first order kinetics.