This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Pelger Huet anamoly shows presence of ? 
Select and explain. 
A. Hyposegmented neutrophil, B. Hypersegmented neutrophil, C. Unsegmented neutrophil, D. None of the above
A: Hyposegmented neutrophil
Answer: A: Hyposegmented neutrophil 
Explanation: Ans. is 'a' i.e., Hyposegmented neutrophil Pelger Huet anomaly It is a genetic disorder with an autosomal dominant inheritance pattern. It is a blood laminopathy associated with the lamin B receptor. It is characterized by a white blood cell type known as a neutrophil whose nucleus is hyposegmented. Heterozygotes are clinically normal, although their neutrophils may be mistaken for immature cells, which may cause mistreatment in a clinical setting. Homozygotes tend to have neutrophils with rounded nuclei that do have some functional problems.