This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
A 35-year-old lady complains of dysphagia, Raynaud's phenomenon and her hands show the following appearance. Investigations show positive ANA. The likely diagnosis is 
Select and explain. 
A. Systemic lupus erythematosus, B. Systemic sclerosis, C. Mixed connective tissue disorder, D. Rheumatoid ahritis
B: Systemic sclerosis
Answer: B: Systemic sclerosis 
Explanation: Systemic sclerosisThe chronic disease is characterized by:1.c/c inflammation, d/t autoimmunity2.Widespread damage to small blood vesselsProgressive interstitial & perivascular fibrosis in skin & multiple organsReference: Harrison&;s principles of Internal Medicine; 19th edition