This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Insulin increases the activities of all of the following enzymes, EXCEPT: 
Select and explain. 
A. Glucokinase, B. Pyruvate carboxylase, C. Glycogen synthase, D. Acetyl-CoA carboxylase
B: Pyruvate carboxylase
Answer: B: Pyruvate carboxylase 
Explanation: B i.e. Pyruvate carboxylase Insulin increases lipogenesis (i.e. FA, TG & glycerol P synthesis) and decrease lipolysis and so free fatty acid levelQ - Insulin activate acetyl CoA carboxylase (rate limiting enzyme of FA synthesis), activate lipoprotein lipase (so increasing TG synthesis) but inhibits hormone sensitive lipase.Q - Insulin decreases gluconeogenesis by inactivating pyruvate carboxylaseQ etc and increases glycolysis by inducing phosphofructokinase and pyruvate kinase enzymesQ.