This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammatory bowel disease, Subject name: Surgery
Sulfasalazine exes its primary action in ulcerative colitis by : 
Select and explain. 
A. Folic acid synthesis, B. Formation of prostaglandins (PG), C. Inhibition of NF-KB Activation, D. Formation of interleukins
C: Inhibition of NF-KB Activation
Answer: C: Inhibition of NF-KB Activation 
Explanation: MOA* Inhibition of NF-KB Activation* Inhibition of PG synthesis* Scavenging of Free radicals 5-ASA compounds exe its local anti-inflammatory effect by inhibiting leukotriene production (PG synthesis) by inhibition of 5-lipooxygenase activity; also inhibits the production of IL-1 and TNF. Commonly Used 5-ASA Formulations in IBD Sulfasalazine Oral mesalamine agents Azo compounds: Balsalazide, Olsalazine