This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
WHich of the following diuretic has high degree of ototoxicity 
Select and explain. 
A. Ethacrylic acid, B. Lasix, C. Spironolactone, D. Bumetanide
A: Ethacrylic acid
Answer: A: Ethacrylic acid 
Explanation: Among loop diuretics, ethacrynic acid is having the highest tendency to produce ototoxicity leading to hearing loss due to excess loss of sodium and potassium ions from the peri and endolymph of ear ototoxicity- self-limited, reversible usually, dose dependent REF KD Tripathi 8th ed