This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: National Immunization Schedule 2020-21, Subject name: Social & Preventive Medicine
On examination, a 34 weeks pregnant lady was found to be HBsAg. What is the management for neonate delivered by Hep B + patient? 
Select and explain. 
A. Hepatitis B vaccine only, B. Immunoglobulin only, C. Hepatitis B vaccine + Immunoglobulin, D. Immunoglobulin followed by vaccine 6 month later
C: Hepatitis B vaccine + Immunoglobulin
Answer: C: Hepatitis B vaccine + Immunoglobulin 
Explanation: Hepatitis B vaccine + Immunoglobulin should be given to a neonate born to mother who is HBsAg positive. The simultaneous administration of HBIG and hepatitis B vaccine is more efficacious than HBIG alone. HBIG does not interfere with the antibody response to the hepatitis B vaccine. This combined procedure is ideal both - for prophylaxis of persons accidentally exposed to blood known to contain hepatitis B virus, and - for prevention of the carrier state in the newborn babies of carrier mothers.