This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following tumours have an increased elevation of placental alkaline phosphatase in the serum as well as a positive immunohistochemical staining for placental alkaline phosphatase - 
Select and explain. 
A. Seminoma, B. Hepatoblastoma, C. Hepatocellular carcinoma, D. Peripheral neuroectodermal tumour
A: Seminoma
Answer: A: Seminoma 
Explanation: Alkaline phosphatase - There are four major sources of Alkaline phosphatase in the body. These are:-

Liver       
Bone    
Intestine
Placenta

So the normal serum alkaline phosphatase consists of 4 isoenzymes secreted from the above-mentioned sites.
Placental alkaline phosphatase is elevated in the following conditions -
(a) Seminoma  
(b) Choriocarcinoma
(c) Third trimester of pregnancy
About other options -
In liver diseases and hepatocellular carcinoma the alkaline phosphatase elevated is of liver origin. Similarly the alkaline phosphatase elevated in bony diseases is due to some pathology in bone.