This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypehyroidism and Goitre, Subject name: Pathology
All of the following are true about Graves disease, except:- 
Select and explain. 
A. More common in males, B. Autoimmune in etiology, C. May result in hypehyroidism, D. Non-thyroid manifestations can also be seen
A: More common in males
Answer: A: More common in males 
Explanation: Graves disease is an autoimmune disorder which is 10 times most common in females presenting in 20-40yrs of age. It causes hypehyroidism d/t overstimulation of TSH receptors by TSIg. Its risk is increased in monozygotic twins. It is associated with ceain genes like HLA-DR3 , HLA-B8. Also associated with other autoimmune disorders like SLE, Type-1 DM, Pernicious anemia, Addison's disease etc. Non-thyroid manifestations like eye & skin involvement can be seen.