This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
The established benefits of estrogen replacement therapy in menopausal woman include a reduction in all of the following EXEPT 
Select and explain. 
A. Osteoporosis, B. Mood depression, C. Atrophic vaginitis, D. Hot flushes
B: Mood depression
Answer: B: Mood depression 
Explanation: Estrogen replacement therapy has many advantages, including reduction in symptoms of estrogen deficiency such as hot flushes, sweating, and atrophic vaginitis. Estrogens have a orable effect on lipoprotein profiles, increasing high-density lipoprotein (HDL) cholesterol and slightly decreasing low-density lipoprotein (LDL) cholesterol. The risk of osteoporosis is also reduced when estrogen replacement therapy is used in combination with calcium supplements. Although menopausal women often feel better physically when receiving estrogen replacement therapy, a few may experience mood depression severe enough to necessitate discontinuation of therapy.