This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Structure and function of protein, Subject name: Biochemistry
All the following are characteristic of I-cell disease except 
Select and explain. 
A. Coarse facial features, B. Corneal clouding, C. Failure to thrive, D. Buphthalmos
D: Buphthalmos
Answer: D: Buphthalmos 
Explanation: Buphthalmos is not a feature of I- cell disease. It is an inherited lysosomal storage disorder Defect in N-acetylglucosaminyl-1-phosphotransferase. Failure of the Golgi to phosphorylate mannose residues on glycoproteins It is characterized by the following: coarse facial features Gingival hyperplasia clouded corneas Restricted joint movements Claw hand deformities Kyphoscoliosis High plasma levels of lysosomal enzymes