This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Muscle, Subject name: Physiology
Z-lines are anchored to the sarcolemma by: 
Select and explain. 
A. Titin, B. Dystrophin, C. Desmin, D. Actinin
C: Desmin
Answer: C: Desmin 
Explanation: Desmin and vimentin are the proteins that anchor Z-lines to sarcolemma. a-actinin and CapZ proteins anchor the thin filaments to the Z-lines. Titin is attached to the Z-line, and it aligns the thick filament in sarcomere. Dystrophin is attached to the ends of thin filaments (toward the center of sarcomere); it extends from thin filament to sarcolemma.