This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
True about sickle anemia is - 
Select and explain. 
A. Leucopenia, B. Decreased ESR, C. Microcardia, D. Ringed sideroblast
B: Decreased ESR
Answer: B: Decreased ESR 
Explanation: Answer- B. Decreased ESRInvestigations in sickle cell anemia-Peripheral smear shows sickle cells, target cell and Howell - Jolly bodies.ESR is decreasedPositive sickling testHb electrophoresis shows two bands in heterozygous state/sickle cell trait.Bone changes on X-ray show:-A. Fish mouth veebraeB. Crew hair cut (hair on end) appearance of skull.('Hair on end appearance' is also seen in thalassemia, hereditaty spherocytosis and G6PD deficiency.)Gamma Gandy bodies