This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Which of the following antihistaminic is free of arrhythmogenic potential? 
Select and explain. 
A. Terfenadine, B. Fexofenadine, C. Loratadine, D. Ebastine
C: Loratadine
Answer: C: Loratadine 
Explanation: Loratidine Loratidine is paially metabolized by CYP3A4 to an active metabolite with a longer T1/2 of 17 hours but in contrast to terfenadine/astemizole, it has not produced cardiac arrhythmia in overdose.