This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Hereditory spherocytosis is due to deficiency of- 
Select and explain. 
A. Ankyrin, B. Actin, C. Selectin, D. Integrin
A: Ankyrin
Answer: A: Ankyrin 
Explanation: HS is caused by diverse mutations that lead to an insufficiency of membrane skeletal components. The pathogenic mutations most commonly affects ankyrin, band 3, spectrin, or band 4.2. Ref :Robbins pathologic basis of disease ; south east asia edition ;pg:633