This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Neutrophilic leukocytosis, lymphoenia, and eosinopenia are most likely associated with which of the following disorders? 
Select and explain. 
A. Endotoxic shock, B. Typhoid fever, C. Whooping cough, D. Cushing syndrome
D: Cushing syndrome
Answer: D: Cushing syndrome 
Explanation: Neutrophilic leukocytosis, lymphopenia, and eosino­penia are most likely associated with Cushing syn­drome and the hypercortisolism associated with the syndrome. Cortisol decreases neutrophil adhesion in the peripheral blood, thus releasing the marginating pool into the circulation. Cortisol also increases lym­phocyte adhesion in the efferent lymphatics and is toxic to eosinophils.
Endotoxic shock results in a neutropenia because endotoxins increase neutrophil adhesion. Absolute neutropenia is a feature of typhoid fever, splenomegaly, and sinus bradycardia. Whooping cough due to Bordetella pertussis produces an absolute lymphocyto­sis. Paroxysmal nocturnal hemoglobinuria, an ac­quired stem-cell disorder with increased sensitivity of hematopoietic cells to complement destruction, is as­sociated with aplastic anemia and pancytopenia.