This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Cancer, Subject name: Pharmacology
Most common agent associated with agranulocytosis is: 
Select and explain. 
A. Steroids, B. Alkylating agents, C. Paracetamol, D. Endotoxemia
B: Alkylating agents
Answer: B: Alkylating agents 
Explanation: Ans. b. Alkylating agentsRef: Harrison 19th e/P 417Most common cause of agranulocytosis is iatrogenic, i.e. drug induced.Most common drugs causing agranulocytosis are anticancer drugs which inhibit cell cycle like alkylating agents and antimetabolites like methotrexate, 5-FU and 6-MP.