This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vitamins and Minerals, Subject name: Biochemistry
Ehlers-Darlos syndrome characterized by hypermobile joints and skin abnormalities is due to: 
Select and explain. 
A. Abnormality in gene for procollagen, B. Deficiency of lysyl oxidase, C. Deficiency of prolyl hydroxylase, D. Deficiency of lysyl hydroxylase
A: Abnormality in gene for procollagen
Answer: A: Abnormality in gene for procollagen 
Explanation: Ans. A. Abnormality in gene for procollagenEhlers-Danlos syndrome comprises a group of inherited disorders whose principal clinical features are hyperextensibility of the skin, abnormal tissue fragility, and increased joint mobility. The clinical picture is variable, reflecting underlying extensive genetic heterogeneity. At least 10 types have been recognized, most but not all of which reflect a variety of lesions in the synthesis of collagen. Type IV is the most serious because of its tendency for spontaneous rupture of arteries or the bowel, reflecting abnormalities in type III collagen. Patients with type VI due to a deficiency of lysyl hydroxylase, exhibit marked joint hypermobility and a tendency to ocular rupture. A deficiency of procollagen N- proteinase, causing formation of abnormal thin, irregular collagen fibrils, results in type VII C manifested by marked joint hypermobility and soft skin.