This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: vitamins, Subject name: Biochemistry
Which of the vitamin deficiency lead to lactic acidosis? 
Select and explain. 
A. Riboflavin, B. Thiamin, C. Niacin, D. Panthotheic acid
B: Thiamin
Answer: B: Thiamin 
Explanation: thiamine deficiency in alcoholism may cause impairment of conversion of pyruvate to acetyl-CoA the result is increased plasma concentration of pyruvate and lactate, leading to lactic acidosis ref DM Vasudevan 8th ed page 467