This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
LE cell is seen in - 
Select and explain. 
A. Lupus erythmatosus, B. Lupus vulgaris, C. HNPCC, D. Medullaiy carcinoma of thyroid
A: Lupus erythmatosus
Answer: A: Lupus erythmatosus 
Explanation: Ans. is 'a' i.e., Lupus erythematosus o In SLE, antinuclear antibodies (ANPs) cannot penetrate intact cells,o However, nuclei are exposed, ANA can bind to them.o In tissues, nuclei of damaged cells react with ANAs, lose their chromatin pattern, and become homogeneous, to produce lupus - erythematosus (LE) bodies or hemotoxylin bodies,o When these LE bodies are engulfed by phagocytic cells (neutrophil or macrophage/monocyte), the phagocytic cells are called LE cells.