This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy: General Principles, Subject name: Pharmacology
Which of the following antitubercular drugs can be safely used in severe renal failure? 
Select and explain. 
A. Streptomycin, B. Ethambutol, C. Capreomycin, D. Rifampicin
D: Rifampicin
Answer: D: Rifampicin 
Explanation: Ans. (D) Rifampicin(Ref: KDT 8th/e p818)Streptomycin and capreomycin are nephrotoxic whereas ethambutol accumulates in renal failure and thus should be avoided in presence of severe renal failure.