This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2019, Subject name: Biochemistry
Rapapo Leubering cycle shift O2 dissociation curve to right because of: 
Select and explain. 
A. 2,3 BPG, B. 1,3 BPG, C. 3 phospho glycerate, D. 1,6 fructose bisphosphate
A: 2,3 BPG
Answer: A: 2,3 BPG 
Explanation: Shifting the O2 dissociation curve to right means decreasing the oxygen saturation of hemoglobin as shown in graph. *2,3 BPG is produced as a result of Rappapo Leubering cycle (RL shunt) as shown in this figure. *This molecule decreases the affinity of hemoglobin for oxygen. Hence it will shift the O2 dissociation curve to the right. Extra Edge Other factors which will also shift the curve to right are: *Increased temperature *increased Carbon dioxide (CO2) *Low pH