This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
The term “end-stage renal disease (ESRD)” is considered appropriate when GFR falls to 
Select and explain. 
A. 50% of normal, B. 25% of normal, C. 10%—25% of normal, D. 5%—10% of normal
D: 5%—10% of normal
Answer: D: 5%—10% of normal 
Explanation: • Most children with GFR >30% of normal are asymptomatic.
• Reduction of GFR below 25—30 mL/min/1.73 m2 is associated with symptoms.
• End-stage renal disease (ESRD)—GFR of 5—10 mL/min/ 1.73 m2, characterized by decline of renal function to a
degree when life cannot be sustained without chronic dialysis or transplantation.