This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The risk of developing infective endocarditis is the least in a patient with - 
Select and explain. 
A. Small VSD, B. Severe aortic regurgitation, C. Severe mitral regurgitation, D. Large ASD
D: Large ASD
Answer: D: Large ASD 
Explanation: None