This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Forensic Medicine
Jamaican vomiting sickness cause by unripe apple fruit toxin? 
Select and explain. 
A. Ricin, B. Muscarin, C. Amaidine, D. Hypoglycin A
D: Hypoglycin A
Answer: D: Hypoglycin A 
Explanation: Ans. is 'd' i.e., Hypoglycin A Jamaican Vomiting Sickness Jamaican vomiting sickness is an acute illness caused by the toxin hypoglycin A, which is present in unripened fruit of the ackee tree. When ingested, hypoglycin A is metabolized to produce methylenecyclopropylacetic acid (MCPA). MCPA acts to inhibit the beta-oxidation of fatty acids. It is characterized by vomiting, coma, free fatty academia, dicarboxylicaciduria, depletion of liver glycogen, fatty degeneration of liver and death.