This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Anti-diabetic effect of sulfonylureas is by reducing: 
Select and explain. 
A. Glucagon production, B. Insulin secretion, C. Tissue sensitivity to insulin, D. Tissue sensitivity to glycogen
A: Glucagon production
Answer: A: Glucagon production 
Explanation: Ans. (A) Glucagon production(Ref: KDT 8/e p294)Sulfonylureas act byIncreasing insulin release from pancreas (not by decreasing insulin secretion), so 'option b' ruled out.A minor action reducing glucagon and increasing somatostatin release has been demonstrated.