This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which is not a 2nd generation anti–histaminic agent ? 
Select and explain. 
A. Cetirizine, B. Cyclizine, C. Loratadine, D. Fexofenadine
B: Cyclizine
Answer: B: Cyclizine 
Explanation: Antihistaminics may be classified into the first generation and the second generation compounds on the basis of CNS penetration and anticholinergic properties. First Generation Anti-histaminics can penetrate the blood-brain barrier and possess additional anticholinergic properties which are lacking in second-generation drugs. Cyclizine is the first generation whereas cetirizine, loratadine and fexofenadine are second generation drugs.