This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplasia, Subject name: Pathology
Most common tumor suppressor gene involved in cancer genesis is? 
Select and explain. 
A. Rb, B. p53, C. p16, D. p73
B: p53
Answer: B: p53 
Explanation: Ans. is 'b' i.e., p53 * p53 is a tumor suppressor gene. p53 gene is located on chromosome 17. p53 acts as molecular policeman that prevents the propagation of genetically damage cell.* p-53 is the most common target for genetic alteration in human tumors; A little over 50% of human tumors contain mutation in this gene.Note - Amongst oncogene RAS is involved most commonly