This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Loss of heterozygosity associated with 
Select and explain. 
A. Acute myeloid leukemia, B. ALL, C. Retinoblastoma, D. Promyelocytic leukaemia
C: Retinoblastoma
Answer: C: Retinoblastoma 
Explanation: Ref Robbins 9/e p292_293 familial case of retinoblastoma 1 defective and 1 normal gene at bih (heterozygous) second mutation causes both genes to be defective loss of heterozygosity Increased chances of cancer sporadic case of retinoblastoma both normal gene at bih _ homogeneous normal genes Both mutations occur somatic Ally within a single cell (homozygous abnormal genes ) increased chances of cancer