This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
All of the following are markers of active replicative of chronic hepatitis B, except: 
Select and explain. 
A. HBV DNA, B. HBV DNA Polymerase, C. HBeAg, D. AST & ALT
D: AST & ALT
Answer: D: AST & ALT 
Explanation: Answer is D (AST & ALT) AST & ALT levels are not considered markers fir active viral replication. . HBV DNA, HBV DNA polymerase and HBeAg levels are all considered markers.* active viral replication, with HBV DNA being the most sensitive marker (gold standard)