This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
The best way of diagnosing Trisomy-21 during second trimester of pregnancy is : 
Select and explain. 
A. Triple marker estimation, B. Nuchal skin fold thickness measurement, C. Chorionic villus sampling, D. Amniocentesis
D: Amniocentesis
Answer: D: Amniocentesis 
Explanation: Ans is d i.e. Amniocentesis