This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
Collagen accumulated in space of Disse in case of liver cirrhosis are 
Select and explain. 
A. 1 and 4, B. 2 and 4, C. 1 and 3, D. 2 and 3
C: 1 and 3
Answer: C: 1 and 3 
Explanation: In the normal liver, ECM consisting of interstitial collagens(fibril forming collagen types I, II, V and XI) is present only in the liver capsule, in poal tracts and around central veins. In cirrhosis, types I and III collagen and other ECM components are deposited in the space of disse. ROBBINS BASIC PATHOLOGY NINTH EDITION PAGE 607