This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Streptococcus toxin which is responsible for connective tissue breakdown ? 
Select and explain. 
A. Hyaluronidase, B. Streptolysin 0, C. Streptolysin S, D. Streptococcus pyogenic exotoxin
A: Hyaluronidase
Answer: A: Hyaluronidase 
Explanation: Ans. is 'a' i.e., Hyaluronidase Hyaluronidase splits hyaluronic acid, an impoant component of the ground substance of connective tissue. Thus, hyaluronidase aids in spreading infecting microorganisms (spreading factor).Hyaluronidases are antigenic and specific for each bacterial or tissue source. Following infection with hyaluronidase-producing organisms, specific antibodies are found in the serum.