This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Acute Inflammation - Overview and Morphologic Patterns, Subject name: Pathology
Increased vascular permeability in acute inflammation is due to - 
Select and explain. 
A. Histamine, B. IL 2, C. TGF beta, D. FGF
A: Histamine
Answer: A: Histamine 
Explanation: Ans. is 'a' i.e., Histamine EFFECTS OF VARIOUS MEDIATORSo Various effects of inflammatory mediators areIncreased vascular permeability Histamine, serotonin (5-hydroxytryptamine), anapkylotoxins (C3a, C4a, C5a), PAF, leukotrienes (LTC4, D4, E4), bradykinin.# PAF is the most potent one to increase permeability.ChemoattractantC5a (most potent), IL-8, LTB4, PAF, bacterial products, Lymphokine, Kallikrein.# C5a is the most potent chemoattractant.Vasodilatation Histamine, prostaglandins (PG D2, PGE2), prostacyclins (PGI2), serotonin. Nitric oxide, bradykinin.Vasoconstriction Leukotrienes (LTC4, D4, E4), Th rom boxane A2.Bronchoconstriction Leukotrienes (LTC4, D4, E4), PFA, histamine, bradykinin.# Leokotrienes (LTC4, D4, E4) are most potent bronchoconstrictors.Pain Prostaglandins, bradykinin.Fever (pyrogens) IL-1, TNF-al IL-6, prostaglandins, interferon.