This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
The phenomenon where subsequent generations are at risk of earlier and more severe disease is known as 
Select and explain. 
A. Anticipation, B. Pleiotropy, C. Imprinting, D. Mosaicism
A: Anticipation
Answer: A: Anticipation 
Explanation: Ref Robbins 9/e p169 Anticipating refers to observation that clinical features of a genetic disease worsen with each successive generations.it is observed in fragile X syndrome and Huntington disease commonly