This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Increased ratio of insulin to glucagon causes: 
Select and explain. 
A. Decreased levels of cyclic AMP, B. Decreased levels of lipoprotein lipase, C. Decreased amino acid synthesis, D. Enhanced lipolysis in adipose tissue
A: Decreased levels of cyclic AMP
Answer: A: Decreased levels of cyclic AMP 
Explanation: Glucagon acts via increase in intracellular cAMP. So, in high insulin glucagon ratio, cAMP level in the cell decreases. Insulin causes activation of lipoprotein lipase and inhibition of hormone­-sensitive lipase. Because of this, there is increased fatty acids synthesis in adipose tissue. Insulin also increases amino acid uptake and protein synthesis in muscles. Normal insulin­ glucagon molar ratio on a balanced diet is approximately 2.3.