This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolic Disorders of Bone, Subject name: Orthopaedics
Which is the drug of choice in Paget's disease? 
Select and explain. 
A. Alendronate, B. Steroids, C. Allopurinol, D. Calcitonin
A: Alendronate
Answer: A: Alendronate 
Explanation: Treatment of Paget's disease Mithramycin (Plicamycin), an anti-neoplastic agent (toxic to osteoclast) was the first drug used for paget's disease. DOC is Bisphosphonates - Etidronate was used first, Alendronate , Risedronate is preferred now. Calcitonin is used for acute relief of pain(temporary effect).