This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: TB of the Spine, Subject name: Orthopaedics
What causes both destruction of bone and reduction of joint space? 
Select and explain. 
A. Tuberculosis, B. Metastasis, C. Multiple myeloma, D. Lymphoma
A: Tuberculosis
Answer: A: Tuberculosis 
Explanation: (a)TB in spine involves- 2 Vertebra (Bone) + Disk (Cartilage)- Paradiscal- Anterior (to spinal cord)Note: Involvement of posterior elements and single vertebra is relatively rare in TB.