This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
The most general term for the process by which the amount of active drug in the body is reduced after absorption into the systemic circulation is: 
Select and explain. 
A. Excretion, B. Elimination, C. First pass metabolism, D. Distribution
B: Elimination
Answer: B: Elimination 
Explanation: * If the amount of active drug reduces in the body before it enters the systemic circulation, it is called first pass metabolism, whereas if the amount of active drug reduces in body after it enters systemic circulation, it is called elimination. *Elimination is the term used for termination of action of a drug. * It is a broader term that includes both metabolism as well as excretion.