This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
Which antigen is not of prognostic significance in carcinoma breast 
Select and explain. 
A. Her 2 neu, B. Epithelial membrane antigen, C. ER, D. PR
B: Epithelial membrane antigen
Answer: B: Epithelial membrane antigen 
Explanation: The presence of hormone receptors confers a slightly better prognosis.The highest rate of response (approximately 80%) to antiestrogen therapy (oophorectomy or tamoxifen) is seen in women whose tumor cells express both estrogen and progesterone receptors Overexpression of HER2/NEU:Overexpression of this membrane-bound protein is almost always caused by gene amplification ref : Robbins Basic Pathology, 9E,page-713