This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Ohopedics Oncology, Subject name: Orthopaedics
Which of the following is a differential of giant cell tumor? 
Select and explain. 
A. Ossifying fibroma, B. Non-ossifying fibroma, C. Osteogenic sarcoma, D. Chondroblastoma
B: Non-ossifying fibroma
Answer: B: Non-ossifying fibroma 
Explanation: Eccentric lytic lesion with no calcification is the commonest differential. Calcification: Ossifying fibroma, chondroblastoma osteosarcoma hence non-ossifying fibroma is a preferred answer here. Non-ossifying fibroma Benign (non-cancerous) Eccentric Age <15 years Non-aggressivetumor Metaphyseal lesion Sclerotic margin Histologically Giant cell with foam cell Note: Closest differential is ABC.