This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
True statement about clonidine are all except- 
Select and explain. 
A. Increases parasympathetic outflow, B. Decreases sympathetic outflow by blocking central alpha receptor, C. Used in Hypertension, D. Prazosin is used to antagonize side effects of clonidine
D: Prazosin is used to antagonize side effects of clonidine
Answer: D: Prazosin is used to antagonize side effects of clonidine 
Explanation: Ans-D Clonidine is an alpha-2 agonist that acts by decreasing the central sympathetic outflow.Sedation, dry mouth and rebound hypertension are the principal adverse effects associated with clonidine. Prazosin is an a1 selective blocker, therefore it is not able to block alpha-2 mediated actions.