This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Pathology
Methylation of cytosine leads to: 
Select and explain. 
A. Increased expression of gene, B. Decreased expression of gene, C. No effect on gene expression, D. Mutation
B: Decreased expression of gene
Answer: B: Decreased expression of gene 
Explanation: High levels of DNA methylation in gene regulatory elements typically result in transcriptional silencing. METHYLATION = MUTE ACETYLATION =ACTIVE