This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
The major clinical manifestation of Wilson disease in children 8-16 years of age is 
Select and explain. 
A. Hepatic dysfunction, B. Cardiac failure, C. Thromboembolic event, D. Blindness
A: Hepatic dysfunction
Answer: A: Hepatic dysfunction 
Explanation: Hepatic dysfunction Wilson's disease or hepatolenticular degeneration is an autosomal recessive disease in which copper accumulates in tissues this manifests as neurological or psychiatric symptoms and liver disease. The condition is due to mutation in the Wilson disease protein (ATP7B) gene Hepatic manifestation occur in 50% of patient mean age of onset of hepatic manifestation is 11.4year.