This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
The most serious complication of clomiphene therapy for induction of ovulation is : 
Select and explain. 
A. Bone marrow depression, B. Hyperstimulation syndrome, C. Secondary amenorrhea, D. Multiple pregnancy
B: Hyperstimulation syndrome
Answer: B: Hyperstimulation syndrome 
Explanation: Ovarian hyperstimulation syndrome is the most dreaded complication of Clomiphene (discussed in detail in chapter 9 on infertility).