This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Intravenous Anesthetic Agents, Subject name: Anaesthesia
Which of the following intravenous anaesthetic agent pharmacokinetic does not change on renal and hepatic dysfunction - 
Select and explain. 
A. Propofol, B. Thiopentone, C. Etomidate, D. Ketamine
A: Propofol
Answer: A: Propofol 
Explanation: Propofol is metabolized by liver and kidney mainly. but its metabolism exceeds hepatic blood flow, thus having extrahepatic and renal route as well. in liver and kidney dysfuction its metabolism is not delayed making its use safe.