This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Bisphoshonates are prescribed to a patient with the following advice 
Select and explain. 
A. Take empty stomach with plenty of water, B. Take after meals, C. Duscintunes if gastritis develops, D. Discontinues if severe bone pain occurs
A: Take empty stomach with plenty of water
Answer: A: Take empty stomach with plenty of water 
Explanation: Refer KDT 7th/345 Bisphoshonates are to be taken empty stomach in the morning with full glass water and patient is instructed not to lie down or take food for at least 30 min. These measures are required to prevent contact of the drug with esophageal mucosa which result in esophagitis