This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
treatment of withdrawal is required in ? 
Select and explain. 
A. LSD, B. Opium, C. Alcohol, D. Amphetamine
A: LSD
Answer: A: LSD 
Explanation: Ans. is 'a' i.e., LSD Clinically significant withdrawal syndrome (requires treatment) :-Alcohol, opioids, amphetamines, Barbiturates, BZDs, Nicotine. No or minimal clinically significant withdrawal syndrome (requires no treatment) :- LSD (nil), Cannabis (minimal).