This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Bio-Chemistry), Subject name: Biochemistry
NADPH oxidase deficiency causes: 
Select and explain. 
A. Chedickhigasi syndrome, B. Chronic granulomatous disease, C. Leucocyte adhesion defect type 1, D. Leucocyte adhesion defect type 2
B: Chronic granulomatous disease
Answer: B: Chronic granulomatous disease 
Explanation: ANSWER: (B) Chronic granulomatous diseaseREF: Medical biochemistry at a glance J. G. Salway page 47, The Metabolic basis of inherited disease John Bruton Stanbury page 1971Chronic granulomatous disease is a rare, X-linked deficiency of NADPH oxidase activity which drastically impairs the ability of macrophages and neutrophils to destroy pathogens. Patients are especially vulnerable to mycobacteria, E coli, and staphylococcus since these organisms produces catalase to defend themselves against hydrogen peroxide attack by phagocytes.