This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Pathology
An obese woman with type 2 diabetes and hypeension is diagnosed with endometrioid type of endometrial carcinoma. The most likely gene defect in this patient is 
Select and explain. 
A. P53, B. PTEN, C. MSH2, D. BRCA2
B: PTEN
Answer: B: PTEN 
Explanation: Type 1 endometrial cancer is associated with PTEN gene. Type 2 endometrial cancer is associated with p53 gene mutation. Type 1 Endometrial cancer Type 2 Endometrial cancer 55-65 years 65-75 years Unopposed estrogen Obesity Hypeension Diabetes Atrophy Thin physique Endometroid Serous clear cell Hyperplasia Serous endometrial intraepithelial carcinomas Indolent Aggressive