This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2019, Subject name: Pharmacology
Which of the following combinations can result in severe toxicity due to inhibition of cytochrome 450 enzymes? 
Select and explain. 
A. Amiodarone + phenytoin, B. Carbamazepine + phenytoin, C. Atorvastatin + Itraconazole, D. Phenytoin + Rifampin
C: Atorvastatin + Itraconazole
Answer: C: Atorvastatin + Itraconazole 
Explanation: Atorvastatin is a statin which is anti dyslipidemic agent and itraconazole is an azole which is anti fungal which are metabolised by Cytochrome 450 oxidase enzyme. Due to inhibition of Cytochrome enzyme toxicity occurs. So third option is a better one.