This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
Gene affected in breast cancer? 
Select and explain. 
A. WT1, B. p53, C. RAS, D. p83
B: p53
Answer: B: p53 
Explanation: Ans. is 'b' i.e., p53 * Most common gene involved infamilial breast cancer - BRCA-1* Most common gene involved in sporadic breast cancer -p53* Most common gene involved overall (Hereditory plus sporadic) - p53* Maximum increase in susceptibility to breast cancer is seen with - p53 mutation (>90%) whether it is sporadic or Hereditary.