This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Febrile response in CNS is mediated by 
Select and explain. 
A. Bacterial toxin, B. IL1, C. IL6, D. Interferon
A: Bacterial toxin
Answer: A: Bacterial toxin 
Explanation: ref Harrison 18/e 143p -145 Fever is produced in response to substance called pyrogens that acts by stimulating prostaglandins synthesis in vascular and periferal cells of hypothalamus.there are exogenous and endogenous pyogens