This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
Treatment of choice in severe depression is - 
Select and explain. 
A. Fluoxetine, B. Alprazolam, C. ECT, D. None
A: Fluoxetine
Answer: A: Fluoxetine 
Explanation: Make it very clear in your mind that the initial treatment of choice for severe depression is antidepressant medications.
ECT is the treatment of choice when severe depression is associated with a suicidal tendency or when severe depression is associated with psychotic features or when severe depression is refractory to antidepressants.