This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
True about Wilson’s disease 
Select and explain. 
A. Decreased urinary excretion of copper, B. Increased ceruloplasmin in blood, C. Decreased copper and ceruloplasmin in serum, D. Decreased urinary excretion of ceruloplasmin
C: Decreased copper and ceruloplasmin in serum
Answer: C: Decreased copper and ceruloplasmin in serum 
Explanation: In Wilson’s disease, there is almost always a failure of synthesis of ceruloplasmin; however, some 5% of patients have a normal circulating ceruloplasmin concentration and this is not the primary pathogenic defect. The amount of copper in the body at birth is normal but thereafter it increases steadily; the organs most affected are the liver, basal ganglia of the brain, eyes, kidneys and skeleton.