This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which of the following neuronal pathways are implicated in amyotropic lateral sclerosis? 
Select and explain. 
A. Involves posterior column only, B. Involves lower motor neuron only, C. Involves Raphae nucleus, D. Involves both upper and lower motor neurons
D: Involves both upper and lower motor neurons
Answer: D: Involves both upper and lower motor neurons 
Explanation: Amyotropic lateral sclerosis is the commonest form of progressive motor neuron disease.