This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypeension, Arrhythmias, Dyslipidemia, Subject name: Pharmacology
Which of following HMG CoA reductase inhibitor has longest half life? 
Select and explain. 
A. Atorvastatin, B. Simvastatin, C. Rosuvastatin, D. Pitavastatin
C: Rosuvastatin
Answer: C: Rosuvastatin 
Explanation: Rosuvastatin - Longest acting Pitavastatin - most potent - Statins have maximum LDL lowering capacity. - Given at night because HMG CoA reductase is maximum active at night but Atorvastatin and Rosuvastatin are long acting drugs, thus can be given any time of the day. - Statins can cause myopathy