This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nephrotic Syndrome, Subject name: Pathology
An IV drug abuser develops an aggressive form of nephrotic syndrome that does not respond to steroids. A renal biopsy is performed. Which of the following histological diagnoses will most likely be made from the biopsy tissue? 
Select and explain. 
A. Focal segmental glomerulosclerosis, B. IgA nephropathy, C. Membranous glomerulonephritis, D. Membranoproliferative glomerulonephritis
A: Focal segmental glomerulosclerosis
Answer: A: Focal segmental glomerulosclerosis 
Explanation: Focal segmental glomerulosclerosis Associated with IV drug abuse and HIV nephropathy. Aggressive form of nephrotic syndrome Poor prognosis Non responsive to steroid therapy (called as 'collapsing variant').