This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following eicosanoids cause vasoconstriction as well as increase vascular permeability? 
Select and explain. 
A. Prostacyclin, B. Thromboxane A2, C. PGE1, D. Leukotriene C4
D: Leukotriene C4
Answer: D: Leukotriene C4 
Explanation: Principal Inflammatory Actions of Arachidonic Acid Metabolites (Eicosanoids) ACTION EICOSANOIDS Vasodilation PGI2 (prostacyclin), PGE1, PGE2, PGD2 Vasoconstriction Thromboxane A2, leukotrienes C4, D4, E4 Increased vascular permeability Leukotrienes C4, D4, E4 Ref: Robbins 8th edition Chapter 2.