This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glucose Transpo, Subject name: Biochemistry
Which of the following is defective in renal glycosuria: 
Select and explain. 
A. GLUT- 1, B. GLUT- 2, C. SGLT- 1, D. SGLT- 2
D: SGLT- 2
Answer: D: SGLT- 2 
Explanation: Renal Glycosuria (also called Familial Renal Glucosuria or Glycosuria ) Blood glucose is normal, But still Glucose appears in urine. It is due to defect/mutation in SGLT-2, which is major glucose transpoer (90% glucose reabsorption) present in kidneys for the reabsorption and transpo of Glucose (see fig below). Mutation in SGLT-1 (10% glucose reabsoption) leads to glucose-galactose malabsorption