This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Which of the following is true about anaphylaxis: September 2007 
Select and explain. 
A. It is mediated by allergen specific IgE, B. Type-I hypersensitivity reaction, C. Cytokines like IL4, IL5 and IL6 along with histamine is released, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: Ans. D: All of the above Anaphylaxis is an acute multi-system severe type I hypersensitivity reaction. Based on the pathophysiology, anaphylaxis can be divided into "true anaphylaxis" and "pseudo-anaphylaxis" or "anaphylactoid reaction." The symptoms, treatment, and risk of death are the same; however, "true" anaphylaxis is caused by degranulation of mast cells or basophils mediated by immunoglobulin E (IgE), and pseudo-anaphylaxis occurs without IgE mediation