This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Oesophagus, Subject name: Surgery
Boerhaave syndrome involves perforation of which part? 
Select and explain. 
A. Upper 1/3 esophagus, B. Middle 1/3 esophagus, C. Lower 1/3 esophagus, D. Fundus of stomach
C: Lower 1/3 esophagus
Answer: C: Lower 1/3 esophagus 
Explanation: Ans. is 'c' i.e., Lower 1/3 esophagus * Boerhaave's syndrome is spontaneous perforation of the esophagus, occuring usually due tosevere barotrauma when a person vomits against a closed glottis. The pressure in the esophagus rapidly increases and the esophagus bursts at its weakest point, sending a stream of material into the mediastinum and often the pleural cavity as well.* Most common location of perforation is in the left posterolateral aspect 3-5 cm above the gastroesophageal junction. Second most common site of perforation is at the midthoracic esophagus on the right side.* Most cases follow a bout of heavy eating and drinking.* The principal early manifestation is pain felt in the chest and upper abdomen.