This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Moderate to high titres of anti-DNA and anti-Smith antibodies are almost pathognomonic of: 
Select and explain. 
A. SLE, B. EM, C. Lichen planus, D. All of the above
A: SLE
Answer: A: SLE 
Explanation: Laboratory Findings
Antinuclear antibodies are frequently found in patients with SLE and can be used to indicate a systemic involvement, but patients with other rheumatologic diseases, such as Sjögren’s syndrome and rheumatoid arthritis, may be positive as well. Moderate to high titers of anti-DNA and anti-Smith antibodies are almost pathognomonic of SLE.