This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Female genital Tract, Subject name: Pathology
40 year old female came to gynae OPD with a complaint of genital ulcer. Physical examination reveals desquamated epithelium and inflammed ulcer bed . Histopathological examination of the inflammatory exudate reveals multinucleated squamous cells with eosinophilic to basophilic viral inclusions with ground glass apearance. Which of the following is most likely the cause ? 
Select and explain. 
A. Candida albicans, B. Herpes simplex Virus, C. Molluscum contagiosum, D. Gardnerella vaginalis
B: Herpes simplex Virus
Answer: B: Herpes simplex Virus 
Explanation: Herpes Simplex Virus HSV are DNA viruses. There are 2 serotypes of HSV : HSV-1 and HSV-2. HSV-1 causes mainly oral infections and HSV-2 causes mainly genital infections in both males and females. Genital HSV infection is common and may involve cervix , vagina, vulva in females. Histopathological examination shows characterstic cytopathic changes consisting of multinucleated squamous cells containing eosinophilic to basophilic viral inclusions with a ground glass pattern. Image showing the viral cytopathic effect of HSV : multi-nucleation and ground glass chromatin