This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Epithelial granuloma is caused by- 
Select and explain. 
A. Neutrophil, B. Cylotoxic T-cells, C. Helper T-cells, D. NK cells
C: Helper T-cells
Answer: C: Helper T-cells 
Explanation: Ans. is 'c' i.e., Helper T.cells Granulomatous inflammation is characterized by presence of epitheloid cells. These epitheloid cells are actually activated macrophages. The immune granulomas are formed when infection occurs with microbes which are capable of inducing cell mediated response. In these cases i.e., type IV Hypersensitivity T-helper cells produces IL-2 which activates other T cells and macrophages, the activated macrophages in turn form epitheloid cells and help in granuloma formation.