This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pediatrics
LEIGH disease is due to the accumulation of 
Select and explain. 
A. Glycogen, B. Pyridoxine, C. Sphingomyelin, D. None of the above
A: Glycogen
Answer: A: Glycogen 
Explanation: (A) Glycogen # L eigh's disease or, subacute Necrotizing Encephalopathy> Is characterized by an arrest of psychomotor development, feeding problem, seizures, extraocular palsies, and weakness with hypotonia between one and 2 years of age> The cardinal Laboratory finding is lactic Addenda> Various biochemical abnormalities have been found, all of which lie in the mitrochondrial pathway for converting pyruvate to ATP.