This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Psychiatric Illness, Subject name: Pharmacology
Mark the true statement regarding use of Lithium in maniac-depressive psychosis? 
Select and explain. 
A. Monotherapy for acute episodes, B. Monitoring of serum concentration is not useful for guiding dose adjustment, C. Can result in leucocytosis, D. Can result in hypehyroidism on long term use
C: Can result in leucocytosis
Answer: C: Can result in leucocytosis 
Explanation: Lithium Use : Prophylaxis of mania alone, with sedatives in acute mania. Monitoring of S. concentration is significant to know the toxicity of drug S/E of Lithium Lithium use for a long time causes benign and reversible T-wave flattening Seizures Polyuria and compensatory polydipsia Dermatitis, folliculitis, vasculitis Weight gain