This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Preformed antibodies cause 
Select and explain. 
A. Hyperacute rejection, B. Acute rejection, C. Chronic rejection, D. Acute humoral rejection
A: Hyperacute rejection
Answer: A: Hyperacute rejection 
Explanation: Rejection- Antibody mediated Humoral or hyperacute rejection When preformed antidonor antibodies are present in circulation of recipient Previous rejection of a transplant Multiparous women Prior blood transfusions Mechanisms of injury - complement dependent cytotoxicity, inflammation, ADCC. Target is graft vasculature - rejection vasculitis