This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Peripheral smear of neonate with ABO incompatibility with show? 
Select and explain. 
A. Microspherocytes, B. Elliptocytes, C. Fragmented RBCs, D. Polychromasis
A: Microspherocytes
Answer: A: Microspherocytes 
Explanation: Ans. is 'a' i.e., Microspherocytes Diagnosing ABO hemolytic disease o There is wide spectrum of severity in ABO hemolytic disease. Neveheless this diagnosis generally should not be made unless there is a positive DAT & clinical jaundice within the first 12 to 24 hours. Reticulocytosis & the presence of microspherocvtes on the smear help to confirm the diagnosis. Criteria for diagnosing ABO hemolytic disease as the cause of neonatal hyperbilirubinemia Mother group 0, infant group A or B Positive DAT Jaundice appearing within 12 to 24 firs Microspherocytes on blood smear Negative DAT but homozygous for Gilbe's syndrome D.4T= Direct Antiglobulin Test or Coombs test