This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Local anesthetics act by blocking 
Select and explain. 
A. Na+ channels from outer side, B. K+ channels from outer side, C. Na+ channels from inner side, D. K+ channels from inner side
C: Na+ channels from inner side
Answer: C: Na+ channels from inner side 
Explanation: Local anesthetics are weak bases that peneterate cell membrane in unionized form and within the cell membrane in ionized form they block voltage gated Na+ Channels.