This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Prostaglandins, Subject name: Pharmacology
Gastric irritation is least with following NSA1D: (PGI June 2008) 
Select and explain. 
A. Diclofenac, B. Acetaminophen, C. Ibuprofen, D. Naproxen
B: Acetaminophen
Answer: B: Acetaminophen 
Explanation: Ans. B (Acetaminophen) "Gastric mucosal damageQ: Gastric pain, mucosal erosion/ ulceration and blood loss are produced by all MSAIDs to varying extents: relative gastric toxicity is a major consideration in the choice of MSAIDs. Paracetamol", a very weak inhibitor of COX is practically free of gastric toxicity and selective (misoprosto) administered concurrently with NSAIDsanatgonise their gastric toxicity"- KDT 6th/186Aspirin is acetylsalicylic acid KDT 6th/187