This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Following antibiotics are safe to treat UTI in pregnancy:a) Aminoglycosidesb) Penicillinc) Cotrmoxazoled) Ciprofloxacine) Cephalosporins 
Select and explain. 
A. ab, B. ad, C. be, D. ce
C: be
Answer: C: be 
Explanation: Principles for management of UTI during pregnancy:

Single dose therapy is preferred
The antimicrobial agent should be appropriate to the mother and fetus, any one of the following drugs could be prescribed:

– Ampicillin
– Nitrofurantoin – DOC for prophylaxis of recurrent UTI in pregnancy
– Cephalexin Cephalosporin
– Amoxicillin clavulanic acid combination.

Sulfonamides should not be given in the third trimester because they may interfere with bilirubin binding and thus impose a risk of neonatal hyperbilirubinemia and kernicterus.
Fluoroquinolones are also contraindicated because of their potential teratogenic effects on fetal cartilage and bone.
Tetracyclines, cotrimoxazole and ciprofloxacin are: contraindicated during pregnancy.