This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
True about hyperophic scar 
Select and explain. 
A. No genetic predisposition, B. More common in blood group A, C. No HLA association, D. Predominantly collagen type 4
B: More common in blood group A
Answer: B: More common in blood group A 
Explanation: Ans is 'b' i.e. More common in blood group A Etiology of hyperophic scarsThey follow damage to deep dermisAutosomal dominant with incomplete inheritance.Associated with HLA B14, B21, Bw16, Bw35, DR5 & DQw3.They are more common in people with 'A' blood group. PathophysiologyHigh level of production of collagen, elastin, fibronectin, proteoglycan & hyaluronic acid by fibroblast.Collagen produced is predominantly type I.There is increased level of TGE-131, P2, activin A, IFN-a & y, plasminogen activator inhibitor 1(PAI1) & low level of urokinaseIL-6 plays a key role in keloid formation.