This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Amyotrophic Lateral Sclerosis and other motor neuron diseases, Subject name: Medicine
All are examples of upper motor neuron lesion except: 
Select and explain. 
A. Prion disease, B. Multiple sclerosis, C. Anterior horn cell disease, D. Tuberous sclerosis
C: Anterior horn cell disease
Answer: C: Anterior horn cell disease 
Explanation: Anterior Horn cell disease =because in this lesion at spinal cord & it comes under lower motor neuron lesion Ant. Horn cell disease / motor neuro disease leads to flaccid paraplegia Prion disease= dementia + myoclonus Multiple sclerosis = optic neuritis Tuberous sclerosis =epilepsy