This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
In pemphigus vulgaris, antibodies are present against: 
Select and explain. 
A. Basement membrane, B. Intercellular substance, C. Cell nucleus, D. Keratin
B: Intercellular substance
Answer: B: Intercellular substance 
Explanation: In Pemphigus antibodies are directed against desmoglein (a trans membrane desmosomal glycoprotein belonging to cadherin-a calcium dependent adhesion molecule) in intercellular substance causing loss of cohesion between epidermal cells (of st. basale layer) I/t formation of acantholytic cells which can be seen on Tzank smear. .