This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Pathology
The phenomenon where subsequent generations are at risk of earlier and more severe disease is known as: 
Select and explain. 
A. Anticipation, B. Pleiotropy, C. Imprinting, D. Mosaicism
A: Anticipation
Answer: A: Anticipation 
Explanation: Anticipation refers to the phenomenon in which clinical features of a genetic disease worsen with each successive generation. Eg : Fragile X syndrome and Huntington disease (CAG repeats).