This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Drugs with high plasma protein binding have: 
Select and explain. 
A. Short duration of action, B. Less drug interactions, C. Lower volumes of distribution, D. All of the above
C: Lower volumes of distribution
Answer: C: Lower volumes of distribution 
Explanation: - Plasma protein binding of drugs causes

   Lower volume of distribution
   Longer duration of action
   Increased drug interactions- due to drug displacement for the binding site.