This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Neoplastic Agents, Subject name: Pharmacology
Hand and foot syndrome is due to - 
Select and explain. 
A. Vincristine, B. Cisplatin, C. 5 FU, D. Azathioprine
C: 5 FU
Answer: C: 5 FU 
Explanation: Ans. is 'c' i.e., 5 FU Hand foot syndromeo Hand foot syndrome is a form erythromyelalgia manifested as tingling, numbness, pain, erythma, swelling and increased pigmentation of hands and feet,o Two most common drugs causing 'Hand foot' syndrome are:Capecitabine (most common)5-FU (2nd most common)Drugs causing 'Hand foot' syndromeCommonly associated drugso Capecitabineo Surafenibo Cytarabino 5-FUo Doxorubicin (liposomo!)Rarely associated drugso Cisplatino Cyclophosphamideo Docetaxelo Daunorubicino Etoposideo Hydroxyureao Methotrexateo Mitotaneo 6-MPo Suramino Paclitaxel