This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
All are the pharmacologic therapeutic options for achalasia, EXCEPT: 
Select and explain. 
A. Nitrates, B. Beta blockers, C. Botulinum toxin, D. Sildenafil
B: Beta blockers
Answer: B: Beta blockers 
Explanation: Pharmacologicals therapies are usually ineffective. They can be used as a temporary measures. The agents used are: 1. Nitrates 2. Calcium channel blockers 3. Botulinum toxin 4. Sildenafil- phosphodiesterase inhibitors, effectively decrease LES pressure. Botulinum toxin, injected into the LES under endoscopic guidance, inhibits acetylcholine release from nerve endings and improves dysphagia in about 66% of cases for at least 6 months Ref: Harrison, Edition-18, Page-2432