This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
In hereditary spherocytosis, an inherited abnormality is seen in which of the following red blood cell component? 
Select and explain. 
A. a-globin chain, B. b-globin chain, C. Phosphatidyl inositol glycan A, D. Spectrin
D: Spectrin
Answer: D: Spectrin 
Explanation: Hereditary spherocytosis (HS) is caused by diverse mutations that lead to an insufficiency of membrane skeletal components. The pathogenic mutations most commonly affect ankyrin, band 3, spectrin, or band 4.2.