This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Physiology
In a case of ectopic pregnancy, medical treatment is contraindicated if 
Select and explain. 
A. Sac size is 3.0 cm, B. Serum HCG levels > 1500 miu/ml, C. Significant hemoperitoneum is present, D. Absent fetal activity
C: Significant hemoperitoneum is present
Answer: C: Significant hemoperitoneum is present 
Explanation: Indications for management of ectopic pregnancy medically.is 1) Ectopic mass <3.5cm 2) No fetal cardiac activity 3) Initial hCG <3000miu/l 4) The patient must be hemodynamically stable, with no signs or symptoms of active bleeding or hemoperitoneum. 5) She should not have any contraindications to the use of methotrexate.