This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Phospholipids, Glycolipids and their disorders, Subject name: Biochemistry
Accumulation of sphingomyelin in phagocytic cells is feature of 
Select and explain. 
A. Gauchers disease, B. Niemann pick ds, C. Tay sachs disease, D. Downs syndrome
B: Niemann pick ds
Answer: B: Niemann pick ds 
Explanation: Ans. is 'b' ie., Niemann pick disease First three options are types of Lysosomal storage disordersThe characteristic feature of lysosomal storage disorders is accumulation of specific macromolecules within cells that are normally metabolized by the cells. This is because of deficiency of one or other lysosomal enzymesSome important lysosomal storage disorders , the deficient enzymes and the stored macromolecule are listed below--Lysomal Storage DiseaseDeficient EnzymeStored Material* Fabry's ds*a- Galactosidase AGlobotriaosyl ceramide* Gaucher's ds*Acid beta - glucosidaseGlucosyl-ceramidase* Niemann - Pick ds*SphingomyelinaseSphingomyelin* Tay -Sach's ds*b - hexosaminidase AGM2 gangliosides* Sandhoff ds*b - hexosaminidase A and BGM2 gangliosides* Hurler's ds*a - L-iduronidaseDermatan sulfate Heparan sulfate* Hunter's ds*Iduronate sulfataseDermatan sulfate* Metachromatic leukodystrophy*Arylsulfatase -ACerebroside - sulfate* Krabbe's ds*GalactosylceramidaseGalactosylceramide Galactosyl sphingosine