This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
Mechanism of action of Triazoles 
Select and explain. 
A. Inhibits cell wall synthesis, B. Inhibits ergosterol biosynthesis, C. Inhibits glucan synthesis, D. Inhibits tubulin
B: Inhibits ergosterol biosynthesis
Answer: B: Inhibits ergosterol biosynthesis 
Explanation: * Triazole antifungals (Fluconazole, Itraconazole, Voriconazole, Posaconazole) inhibit 14-sterol demethylase --> impair the biosynthesis of ergosterol--> resulting in depletion of membrane ergosterol along with accumulation of the toxic product 14-methyl-3,6- diol --> leading to fungal growth arrest. Ref:- Goodman & Gilman Pharmacological Basis of Therapeutics 13th Ed; Pg num:- 1091