This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
The typical 'Orphan-Annie eye' nucleus is described in - 
Select and explain. 
A. Serous cystadenocarcinoma of ovary, B. Renal cell carcinoma, C. Papillary carcinoma of thyroid, D. Seminoma
C: Papillary carcinoma of thyroid
Answer: C: Papillary carcinoma of thyroid 
Explanation: Papillary carcinoma: Accounts for 85% of thyroid malignancy in iodine-deficient areas Most common thyroid cancer in children and in persons exposed to external radiation Most often in women between 30-40 years Excellent prognosis Characteristic nuclear features: Ground glass (Orphan Annie) nuclei pseudoinclusions Nuclear grooves. Nuclear features are used as diagnostic criteria even in the absence of papillae. Papillary carcinoma: Most commonly spreads through lymphatics. Papillary carcinoma: Metastasize through lymphatics and have an excellent prognosis.