This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pharmacology
Drug of choice for prevention of NSAID induced peptic ulcer disease is 
Select and explain. 
A. H2 receptor blockers, B. Proton pump inhibitors, C. Macrolide antibiotic, D. Sucralfate
B: Proton pump inhibitors
Answer: B: Proton pump inhibitors 
Explanation: Ans. is 'b' i.e., Proton pump inhibitors * PPI are the DOC for peptic ulcer (gastric or duodenal), GERD, ZE syndrome, prevention of aspiratory pneumonia and NSAID induced gastric / duodenal ulcers. Note - PGE1 analogue (Misoprostol) is specific drug for prevention and treatment of NSAID induced ulcer, but DOC is PPL