This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General surgery, Subject name: Surgery
High incidence of oral malignancies is attributed to 
Select and explain. 
A. Use of pan, B. Poor hygiene, C. High incidence of HPV, D. Poor nutrition
A: Use of pan
Answer: A: Use of pan 
Explanation: In the Indian subcontinent, the use of 'pan' (a combination of betel nut, areca nut, lime and tobacco), as well as reverse smoking (smoking a cheroot with the burning end inside the mouth), are responsible for the high incidence of oral cancer. Betel quid appears to be the major carcinogen, although there is also a relationship between slaked lime and the areca nut and cancer.Ref: Bailey and love pg: 760