This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
The histology of Lobular carcinoma of breast reveals- 
Select and explain. 
A. Single file pattern, B. Pleomorphic cells in sheets, C. Clustersl/lslands of cells with mucous lakes, D. Solid syncytium like sheets
A: Single file pattern
Answer: A: Single file pattern 
Explanation: Invasive lobular carcinoma consists of cells morphologically identical to the cells of LCIS. Two thirds of the cases are associated with adjacent LCIS. The cells invade individually into stroma and are often aligned in "single-file" strands or chains. This growth pattern correlates with the presence of mutations that abrogate the function of E-cadherin, a surface protein that contributes to the cohesion of normal breast epithelial cells. ref : Robbins Basic Pathology, 9E,page-711 REF of IMG :