This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
True statement about cyclooxygenase -2 is: 
Select and explain. 
A. It is not inhibited by indomethacin, B. It is inducible, C. It generates cytoprotective prostaglandins in gastric mucosa, D. It is found only in fetal tissues
B: It is inducible
Answer: B: It is inducible 
Explanation: COX-1 is a house-keeping enzyme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a nonselective inhibitor of both isoforms of COX.