This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
All of the following represent disorders or protein misfolding, EXCEPT: 
Select and explain. 
A. Alzheimer's disease, B. Tuberculosis, C. Cystic fibrosis, D. Creutzfeldt - Jakob disease
B: Tuberculosis
Answer: B: Tuberculosis 
Explanation: Tuberculosis is not due to protein misfolding. Abnormal folding of proteins lead to pathologic process including loss of function or gain of toxic activity, which result from accumulation of misfolded and aggregated protein in specific tissue. Tissue deposition of misfolded protein result in cell impairement and death leading to clinical symptoms in affected individual. Ref: Current Hypotheses and Research Milestones in Alzheimer's Disease By Ricardo B. Maccioni page172