This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Liver biopsy is indicated in patients with hemochromatosis only if: 
Select and explain. 
A. Elevation of transaminase present, B. Serum ferritin > 1000 g/L, C. Evidence of cirrhosis, D. If percentage saturation of iron is high
B: Serum ferritin > 1000 g/L
Answer: B: Serum ferritin > 1000 g/L 
Explanation: Screening tests for hemochromatosis are: transferrin saturation or ferritin level (Both will be high) Confirmatory test for hemochromatosis: Genetic testing (C282Y homozygote or a compound heterozygote (C282Y/H63D). If the ferritin is >1000 g/L, the patient should be considered for liver biopsy. Ref: Harrison, E-18, P-2603.