This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Small & Large Intestine, Subject name: Surgery
Crohn's disease is associated with polymorphism in: 
Select and explain. 
A. NOD2/CARD 15 gene, B. Philadelphia chromosome, C. P53 gene, D. APC/Beta catenin
A: NOD2/CARD 15 gene
Answer: A: NOD2/CARD 15 gene 
Explanation: Ans. (a) NOD 2/CARD 15 geneRef: Sabiston 20th edition, Page 1260* IBD-1 (CARD-15/NOD 2 gene) mutation at chromosome 16 q is linked with CD.* IBD-2 - Chr.12q-linked with UC