This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
Pedigree analysis--Analyze the following pedigree and give the mode of inheritance: 
Select and explain. 
A. Autosomal recessive, B. Autosomal dominant, C. Mitochondrial inheritance, D. X-linked dominant
C: Mitochondrial inheritance
Answer: C: Mitochondrial inheritance 
Explanation: c. Mitochondrial inheritance(Ref: Nelson's 20/e p 600, Ghai 8/e p 644)This disease is manifesting in both males and females and all children of a diseased female have disease;Both these are characteristics of mitochondrial diseases.