This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
True about imipenem is - 
Select and explain. 
A. It is a narrow spectrum antibiotic, B. It is easily broken by beta lactam, C. It can be used with cilastatin, D. It is used with sulbactam
C: It can be used with cilastatin
Answer: C: It can be used with cilastatin 
Explanation: Ans. is 'c' i.e., It can be used with cilastatin o A limiting feature of imipenem is its rapid hydrolysis by the enzyme dehydropeptidase-I located on the brush border of renal tubular cells. Cilastatin is a reversible inhibitor of dehydropeptidase -1. It protects the imipenem from this enzyme. o Carbapenems have the widest spectrum of all currently available antimicrobials, being bactericidal against most gram positive andgram negative aerobic and anaerobic pathogenic bacteria.