This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Colchicine mechanism of action in acute gout 
Select and explain. 
A. Inhibition of release of chemotactic factors, B. Binding to tubulin and inhibition of leucocyte migration, C. Promotes metabolism of urate crystals, D. Inhibition of leukotriene B4
B: Binding to tubulin and inhibition of leucocyte migration
Answer: B: Binding to tubulin and inhibition of leucocyte migration 
Explanation: Ref. KDT. Page. 214
It does not inhibit the synthesis or promote the excretion of uric acid. – Direct lines from Tripathi, guides may lead you wrong. But they don’t have an effect 
 
Colchicine MOA
The first two points is how it acts in acute Gout

Colchicine does not affect phagocytosis of urate crystals but inhibits release of the glycoprotein and the subsequent events.
By binding to fibrillar protein tubulin, it inhibits granulocyte migration into the inflamed joint and thus interrupts the vicious cycle.
Antimitotic: causes metaphase arrest by binding to microtubules of mitotic spindle.
Increases gut motility through neural mechanisms