This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Parasitic Drugs, Subject name: Pharmacology
Ivermectin act by ? 
Select and explain. 
A. Inhibition of pyruvate ferridoxin oxidoreductase, B. Inhibition of Nicotinic Acetycholine receptor, C. Activation of Glutamate gated Chloride channels, D. Inhibition of heme polymerase
C: Activation of Glutamate gated Chloride channels
Answer: C: Activation of Glutamate gated Chloride channels 
Explanation: Ivermectin : MOA :induce paralysis by activating Glutamate-gated Cl- channels foundonly in Inveebrates(Nematode nerve or muscle cells) and causes hyperpolarizationby increasing intracellular Chloride concentration, resulting in paralysis.It also binds with high affinity to GABA-gated and other ligand-gated Cl- channels in nematodes such as Ascaris . USES: It is drug of choice for Strongyloidiasis and Onchocerciasis. It is also useful for Ascariasis, Enterobiasis, Cutaneous Larva Migrans and Uncomplicated Scabies.