This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Malabsorbtion Syndrome, Subject name: Medicine
A 30 year old lady presents with features of malabsorption and iron deficiency anaemia. Duodenal biopsy shows complete villous atrophy, Probable diagnosis can be asceained on detection of which antibody : 
Select and explain. 
A. Antiendomysial antibodies, B. Anti -goblet cell antibodies, C. Anti - Saccharomyces cerevisae antibodies, D. Antineutrophil cytoplasmic antibodies
A: Antiendomysial antibodies
Answer: A: Antiendomysial antibodies 
Explanation: Differential diagnosis of this patient is Celiac disease Best screening test for diagnosis of celiac sprue -anti-Tissue transglutaminase antibody > Anti-endomyosial antibody Malabsorption and anemia is seen due to proximal gut > distal pa of small intestine Biopsy from Distal duodenum or proximal jejunum - loss or blunting of intestinal mucosa.