This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anatomy of Skin, Subject name: Skin
Which layer of epidermis is underdeveloped in pre-term baby? 
Select and explain. 
A. Stratum germinativum, B. Stratum granulosum, C. Stratum lucidum, D. Stratum corneum
D: Stratum corneum
Answer: D: Stratum corneum 
Explanation: Ans. d. Stratum corneumStratum corneum is underdeveloped in preterm or very low birth weight (VLBW) infants in initial 7 days.The development of the layers of the epidermis starts from below upwards. Therefore, stratum basale is first to be form and stratum corneum is the last layer to form.In preterm infants, stratum corneum is permeable and becomes similar to the adult and full term infant after 2 to 3 weeks postnatal maturation.