This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Joint disorders, Subject name: Anatomy
Which NSAID can cause hyperuricemia? 
Select and explain. 
A. Tolmetin, B. Ibuprofen, C. Aspirin, D. Naproxen
B: Ibuprofen
Answer: B: Ibuprofen 
Explanation: ASPIRIN can cause hyperuricemia depending on dose used. At low doses :1-2g/day -decrease uricacid excretion and hence cause hyperuricemia. It also blocks the effects of probencid and other uricosuric drugs. Intermediate doses:2-3g/day-No effect Large doses:>5g/day-uricosuric 1st most commonly used NSAID in hyperurecemia ahritis (gout) is NAPROXONE 2nd most commonly used is IBUPROFEN ref : maheswari th ed