This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
In thromboasthenia there is a defect in – 
Select and explain. 
A. Platelet aggregation, B. Platelet adhesion, C. Decreased ADP release, D. Desordered platelet secretion
A: Platelet aggregation
Answer: A: Platelet aggregation 
Explanation: Platelet adhesion

Platelet adhesion referes to the binding of platelets to subendothelial matrix.
Platelet membrane glycoprotein Ib-IX is essential for platelet adhesion to subendothelial matrix.


Platelet aggregation

Platelet aggregation referres to adherence of platelets to one another.
Platelet membrane glycoprotein ddb-IIIa helps in aggregation.

Congenital dysfunction of platelet
1. Bernard-soulier syndrome

Defect in platelet adhesion due to inherited deficiency of glycoprotein Ib-IX.

2. Glanzmann's thrombasthenia

Defect in platelet aggregation due to inherited deficiency of glycoprotein Ilb-IIIa.