This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
All of the following are decreased in nephrotic syndrome, except – 
Select and explain. 
A. Serum transferrin, B. Serum fibrinogen, C. Serum ceruloplasmin, D. Serum albumin
B: Serum fibrinogen
Answer: B: Serum fibrinogen 
Explanation: Fibrinogen level is increased in nephrotic syndrome d/t increased hepatic synthesis of fibrinogen.
The largest proportion of protein lost in urine is albumin.
Sometimes, globulins can also be excreted → Immunoglobulin excretion increases the susceptibility of infection.
Other proteins which are decreased -
Transferrin → Microcytic hypochromic anemia


Cholecalciferol binding protein → hypocalcaemia
Thyroxine-binding globulin → Decreased thyroxin level
Antithrombin III → Hypercoagulability
Ceruloplasmin