This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Tolcapone is 
Select and explain. 
A. Ototoxic, B. Nephrotoxic, C. Hepatotoxic, D. All of the above
C: Hepatotoxic
Answer: C: Hepatotoxic 
Explanation: Tolcapone is a COMT inhibitor used in Parkinson's disease which acts both peripherally & centrally. But it is hepatotoxic.
Entacapone is a peripheral COMT inhibitor which is safe in hepatic insufficiency.