This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Cytokines are secreted in sepsis and Systemic inflammatory Response syndrome (SIRS) by 
Select and explain. 
A. Neutrophils, B. Adrenal, C. Platelets, D. Collecting duct
A: Neutrophils
Answer: A: Neutrophils 
Explanation: Ans. is 'a' i.e., Neutrophils Cytokine release in Sepsis o Mechanism by which endotoxin causes activation of inflammatory cells and release of cytoine has already been explained earlier. o It is by TLR-4 and CD-14 mediated. Signals from TLR-4 can directly activate vascular endotheliun and leukocytes to release cytokine mediators. o The major cells that secret cytokines in sepsis area 1. Monocyte/Macrophages 2. Neutrophils 3. Endothelial cells o Cytokine mediators involved are :? 1. TNF - (The most impoant cytokine in sepsis) 2. IL-1 3. IL-6 4. IL-8 5. NO.