This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
The most reliable urine specimen is obtained by- 
Select and explain. 
A. Urethral catheterization, B. Catheter aspiration, C. Midstream voiding, D. Suprapubic aspiration
D: Suprapubic aspiration
Answer: D: Suprapubic aspiration 
Explanation: • Most often, the urine is often obtained from a voided specimen.
• In children who are not toilet trained, a urine collection device, such as a bag, is placed over the genitalia, and the urine is cultured from the bagged specimen.
• Suprapubic aspiration avoids potential contamination; however, due to its invasiveness, it is rarely used except in children and selected patients.
• Urine obtained from a urinary catheter is less invasive than a suprapubic aspiration and is less likely to be contaminated than that from a voided specimen.