This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: parasitic infection, Subject name: Medicine
Romana's sign is seen in: 
Select and explain. 
A. Trypanosoma brucei, B. Trypanosoma cruzi, C. Loa loa, D. Wuchereria
B: Trypanosoma cruzi
Answer: B: Trypanosoma cruzi 
Explanation: Romana's sign --the classic finding in Acute Chagas' disease (caused by the parasite Trypanosoma cruzi), which consists of unilateral painless edema of the palpebrae and periocular tissues--can result when the conjunctiva is the poal of entry. Initial local signs may be followed by malaise, fever, anorexia, and edema of the face and lower extremities. Generalized lymphadenopathy and hepatosplenomegaly may develop.