This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Prostaglandins, Subject name: Pharmacology
Prostaglandin inhibiting action of aspirin is useful in the treatment of all of the following conditions, except: 
Select and explain. 
A. Analgesia and antipyresis, B. Closure of ductus arteriosus, C. Uricosuria, D. Anti-inflammatory and anti platelet aggregation
C: Uricosuria
Answer: C: Uricosuria 
Explanation: Ans. (C) Uricosuria(Ref: KDT 8th/e p212, 213)Inhibition of PG synthesis is responsible for analgesic, antipyretic, anti-inflammatory and antiplatelet actions of aspirin. This action is also utilized in the treatment of PDA. High doses of aspirin cause uricosuria whereas therapeutic doses result in hyperuricemia. These effects are unrelated to its action on PG synthesis.