This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lymphoma and Plasma cell disorder, Subject name: Medicine
Popcorn variant of Reed-Sternberg cell is seen in? 
Select and explain. 
A. Follicular center lymphoma, B. Lymphocyte depleted Hodgkin's disease, C. Nodular sclerosis Hodgkin's disease, D. Lymphocyte predominant Hodgkin's disease
D: Lymphocyte predominant Hodgkin's disease
Answer: D: Lymphocyte predominant Hodgkin's disease 
Explanation: Popcorn variant of Reed-Sternberg cell is seen in lymphocyte predominant Hodgkin's disease Variants of Reed -Sternberg Cells Subtypes of Hodgkin's Associated Mononuclear variant = Variant of R.S. cell, mononucleated. Mixed cellularity Lacunar Variant = Large cells with hyperlobated nucleus, multiple small nuclei and eosinophilic cytoplasm around the nucleus creating an empty space called lacunae Nodular sclerosis Lympho-histiocytic variant (popcorn cell variant) = Cell with multiple folded or convoluted nuclear contour resembling a "popcorn kernel" Lymphocytic predominant Note MC subtype of Hodgkin lymphoma : Nodular sclerosis ( Globally ) Mixed cellularity ( In India )