This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which is the most specific tumor marker for melanoma: 
Select and explain. 
A. Tyrosinase, B. Vimentin, C. S-100, D. HMB-45
D: HMB-45
Answer: D: HMB-45 
Explanation: HMB-45 is the most specific tumor marker for melanoma. S-100 is most sensitive.