This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Substance Related and Addictive Disorders, Subject name: Psychiatry
Earliest symptoms showing improvement from the classical triad of Wernicke's encephalopathy to thiamine therapy is: 
Select and explain. 
A. Ataxia, B. Ophthalmoplegia, C. Confusion, D. All improve simultaneously
B: Ophthalmoplegia
Answer: B: Ophthalmoplegia 
Explanation: Wernicke's encephalopathy - Long term use of alcohol lead to thiamine deficiency . Wernicke encephalopathy, caused by vitamin B1 deficiency, is not diagnosed in about 80% of cases. Classical triad Global confusion Ophthalmoplegia - m/c/c 6th nerve palsy Ataxias After thiamine therapy 1st one to improve is ophthalmoplegia followed by global confusion