This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pharmacology
All are true about warfarin, except 
Select and explain. 
A. It inhibits the activation of vitamin K dependent cloting factors, B. Its half life is 36 hours, C. It can cross placenta, D. Its dose is increased in liver disease
D: Its dose is increased in liver disease
Answer: D: Its dose is increased in liver disease 
Explanation: It&;s dose should be reduced in liver and renal impairment as it is metabolized by glucoronide conjugation and is excreted by urine. From medical pharmacology padmaja 4th edition Page no 339,341