This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Unorable interaction of drug and substrate in human beings are all except: 
Select and explain. 
A. Omeprazole reduces stomach acid, B. Methotrexate inhibiting folate, C. Barbiturates decreases B 12 absorption, D. Retinoic acid inhibits vitamin E
A: Omeprazole reduces stomach acid
Answer: A: Omeprazole reduces stomach acid 
Explanation: Ans. a. Omeprazole reduces stomach acid Omeprazole reduces stomach acid secretion: This interaction is beneficial for patients suffering from GERD without having any associated complications. Rest three interactions has a bad impact on the normal healthy individuals. Methotrexate inhibiting folate Barbiturates decreases 13,2 absorption Retinoic acid inhibits vitamin E