This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
The following antibiotic accentuates the neuromu-scular blockade produced by pancuronium: 
Select and explain. 
A. Streptomycin, B. Erythromycin, C. Penicillin G, D. Chloramphenicol
A: Streptomycin
Answer: A: Streptomycin 
Explanation: (Ref: KDT 6e p721, 722) Aminoglycosides (like streptomycin and gentamicin) can accentuate the neuromuscular blockade produced by competitive blockers (like pancuronium). Mechanism of neuromuscular blockade produced by aminoglycosides is the inhibition of presynaptic release of ACh.