This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Ophthalmology
Drugs causing macular toxicity when given intravitreally? 
Select and explain. 
A. Gentamycin, B. Vancomycin, C. Dexamethasone, D. Ceftazidime
A: Gentamycin
Answer: A: Gentamycin 
Explanation: (Refer: AK Khurana Comprehensive Ophthalmology, 6th edition, pg no. 445)Intravitreal aminoglycosides (gentamycin, amikacin) are a repoed cause of macular toxicityAminoglycosides induced macular toxicity is thought to be paially due to the gravity-induced settling of drugs on the macula in the supine positionThis may result in a higher concentration of drug locally at the macula.