This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Wilms Tumor, Subject name: Pathology
The most impoant determinant of prognosis of a patients with Wilms tumor is: 
Select and explain. 
A. Stage of disease, B. Histology, C. Loss of chromosome 1p, D. Age of presentation
B: Histology
Answer: B: Histology 
Explanation: Most impoant factor for prognosis of Wilm's tumor is Histology. Higher the degree of anaplasia - Poorer the prognosis. Presence of anaplasia associated with p53 gene mutation isresponsible for adverse prognosis.