This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical & Surgical Illness Complication Pregnancy, Subject name: Gynaecology & Obstetrics
Congenital anomalies are most severe in: 
Select and explain. 
A. Rubella infection, B. Mumps, C. CMV, D. Toxoplasma
A: Rubella infection
Answer: A: Rubella infection 
Explanation: Ans. is a, i.e. Rubella infectionRef. Williams Obs. 23/e, p 1214"Rubella is one of the most teratogenic agents known." Ref. Williams Obs. 23/e, p 1214Rubella causes a number of serious defects in fetus. These defects may occur singly or in combination called Congenital rubella syndrome.