This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Fibroblasts in healing wound are derived from - 
Select and explain. 
A. Local mesenchyme, B. Epithelium, C. Endothelium, D. Vascular fibrosis
A: Local mesenchyme
Answer: A: Local mesenchyme 
Explanation: Fibroblasts are specialized cells that differentiate from resting mesenchyme cells in connective tissue. They do not arrive in the wound cleft by diapedesis from circulating cells.