This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Regional anaesthesia, Subject name: Anaesthesia
All the following statements about Epinephrine used as an adjuvant are true Except 
Select and explain. 
A. Extends block duration, limits systemic uptake, supplements analgesic effect, and acts as an indicator of intravascular injection, B. Can cause toxicity to peripheral nerves in patients with diabetes or chemotherapy, C. Local anaesthetics and epinephrine have no effect on peripheral nerve blood flow, D. Can aggravate local anaesthetic-induced neuraxial or peripheral nerve injury
C: Local anaesthetics and epinephrine have no effect on peripheral nerve blood flow
Answer: C: Local anaesthetics and epinephrine have no effect on peripheral nerve blood flow 
Explanation: Local anesthetics and epinephrine significantly reduce peripheral nerve blood flow. Low-dosage epidural usage results in uptake and decreases systemic vascular resistance and increases cardiac output.