This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Progressive damage in a cell including the DNA leads to: 
Select and explain. 
A. Necrosis or Apoptosis, B. Atrophy, C. Metaplasia, D. Calcification
A: Necrosis or Apoptosis
Answer: A: Necrosis or Apoptosis 
Explanation: Decreased nutrients lead to atrophy.
Chronic irritation leads to metaplasia.