This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cell Wall Synthesis Inhibitors, Subject name: Pharmacology
Which of the following statements about imipenem is most accurate? 
Select and explain. 
A. The drug has a narrow spectrum of antibacterial action, B. It is used in fixed dose combination with sulbactum, C. In renal dysfunction, dosage reductions are necessary to avoid seizures, D. Imipenem is active against methicillin-resistant staphylococci
C: In renal dysfunction, dosage reductions are necessary to avoid seizures
Answer: C: In renal dysfunction, dosage reductions are necessary to avoid seizures 
Explanation: Carbapenems are synthetic b-lactam antibiotics Imipenem, meropenem, doripenem and eapenem are the drugs of this group currently available. Imipenem : Effective against : Gm +ve, Gm -ve including pseudomonas and anaerobic. Dehydropeptidase by kidney metabolises imipenem rapidly. Cilastatin is a dehydropetidase inhibitor, which must be given along with imipenem for desired action. Side effect : Seizure