This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Local anesthetic is not effective in an inflammed tissue because: 
Select and explain. 
A. All impulses generated cannot be blocked, B. Myelin sheath is inflammed so it does not absorb the solution, C. pH is more acidic, so LA is ineffective, D. All of the above
C: pH is more acidic, so LA is ineffective
Answer: C: pH is more acidic, so LA is ineffective 
Explanation: None