This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Physostigmine was therapeuticallyused for the first time in treatment of glaucoma in 1877 by – 
Select and explain. 
A. Laqueur, B. Posselt and Reiman, C. Ahlquist, D. Sir James Black
A: Laqueur
Answer: A: Laqueur 
Explanation: Laqueur
Posselt and Reiman isolated nicotine from the leaves of Nicotiana tabacum.
Ahlquist gave the hypothesis that adrenaline acts on different sets of receptors, later named as α and β.
Sir James Black synthesized the first β-blocker, dichloroisoproterenol, and subsequently, propranolol.