This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
The patients of Down syndrome has high risk of developing  ________ in the future : 
Select and explain. 
A. Parkinson syndrome, B. Lewy body dementia, C. Alzheimer's disease, D. Juvenile myoclonic epilepsy
C: Alzheimer's disease
Answer: C: Alzheimer's disease 
Explanation: Patients with Down syndrome i.e 21st trisomy has highest risk for developing Alzheimer's disease as gene for APP (Amyloid precursor protein) is present on chromosome 21.