This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urinary tract, Subject name: Pathology
In Wilm&;s tumor the following leads to emergence of resistance to chemotherapy - 
Select and explain. 
A. Nephrogenic rests, B. Monophasic morphology, C. Anaplasia, D. Capsular infiltration
C: Anaplasia
Answer: C: Anaplasia 
Explanation: Approximately 5% of tumors contain foci of anaplasia (cells with large, hyperchromatic, pleomorphic nuclei and abnormal mitoses). The presence of anaplasia correlates with the presence of acquired TP53 mutations and the emergence of resistance to chemotherapy. ROBBINS BASIC PATHOLOGY. 10th edition. Chapter Genetic and Pediatric Diseases. Page no. 290.