This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Diabetes, Subject name: Pharmacology
All are true regarding oral hypoglycemic agent, EXCEPT : 
Select and explain. 
A. Effective only after total pancreatectomy, B. Metformin causes lactic acidosis, C. Causes release of insulin from beta-cells, D. Useful in obese maturity onset diabetics
A: Effective only after total pancreatectomy
Answer: A: Effective only after total pancreatectomy 
Explanation: Ans. is 'a' Effective only after total pancreatectomy Mechanism of action of sulfonylureasPresence of at least 30% functional pancreas is necessary for the action of oral hypoglycemics (Sulfonyl ureas).They act on sulfonylurea receptors present on beta cells of pancreas. This increase insulin secretion.Oral hypoglycemics are used only in uncomplicated type 11 diabetes (N1DDM).Both phenformin and metformin cause lactic acidosis (Phenformin > metformin).