This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Statin having longest half life: September 2012 
Select and explain. 
A. Rosuvastatin, B. Pravastatin, C. Simvastatin, D. Lovastatin
A: Rosuvastatin
Answer: A: Rosuvastatin 
Explanation: Ans. A i.e. Rosuvastatin Rosuvastatin It is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins. Its approximate elimination half life is 19 h and its time to peak plasma concentration is reached in 3-5 h following oral administration.