This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Organ Transplant / Graft, Subject name: Pathology
Which of the following is not a poor prognostic factor in neuroblastoma? 
Select and explain. 
A. MYCN amplification, B. High mitosis-karyorrhexis index, C. Evidence of gangliocytic differentiation, D. Mutations of neuritogenesis genes
C: Evidence of gangliocytic differentiation
Answer: C: Evidence of gangliocytic differentiation 
Explanation: Unourable prognostic factors in neuroblastoma: Stage 3, 4 Age >18 months Absence of evidence of schwannian stroma and gangliocytic differentiation High Mitosis-karyorrhexis index (>200/5000 cells) Near-diploid (segmental chromosome losses; chromothripsis) MYCN Amplified Chromosome 1p loss Chromosome 11q loss Absent TRKA expression Presence of TRKB expression Mutations of neuritogenesis genes