This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Most pathognomonic sign of irreversible cell injury 
Select and explain. 
A. Amorphous densities in mitochondria, B. Swelling of the cell membrane, C. Ribosomes detached from endoplasmic reticulum, D. Clumping of the nucleus
A: Amorphous densities in mitochondria
Answer: A: Amorphous densities in mitochondria 
Explanation: Ref, Robbins 7/ep12,9/ep50