This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Cyclo-oxygenase-1 (COX-1) isoenzyme: 
Select and explain. 
A. Is increased by inflammation, B. Is predominant mode of action of Indomethacin, C. Is increased by lipopolysaccharide ie G –ve endotoxin, D. Is NOT involved in gastric mucosal protection
B: Is predominant mode of action of Indomethacin
Answer: B: Is predominant mode of action of Indomethacin 
Explanation: Option A, C & E is incorrect as Cyclo-Oxygenase -1 (COX-1) is a constitutive Enzyme.
Option B is correct as – Indomethacin does affect it as it’s nonselective.
​Option D is incorrect as COX-1, plays a central role in protection of the gastric mucosa, by helping in the synthesis of Prostaglandins.