This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Gastrointestinal stromal malignancy arises from which of the following - 
Select and explain. 
A. Smooth muscle, B. Nerve cells, C. Interstitial cells of Cajal, D. Vascular Endothelium
C: Interstitial cells of Cajal
Answer: C: Interstitial cells of Cajal 
Explanation: "Gastrointestinal stromal tumors (GIST) originate from the interstitial cells of Cajal, which controls gastrointestinal peristalsis."

On rare occasions, gastric GISTs occur as part of tumor - syndrome, such as :-


Carney's trads → Gastric GIST, Paraganglioma and pulmonary chondroma.
Neurofibromatosis Type I


Histologically, GISTs can be divided into


Spindle types → Exhibit spindle cells
Epithelioid types → Exhibit epithelioid cells
Mixed types → A mixture of both