This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplastic disorders of WBCs, Subject name: Pediatrics
AML with worst prognosis: 
Select and explain. 
A. 8/21 translocation, B. Inversion 16, C. Normal cytogenetics, D. Monosomy 7
D: Monosomy 7
Answer: D: Monosomy 7 
Explanation: PROGNOSIS OF AML: Good prognostic factors: t(8;21) inv16 t(15;17) CEBPA mutation NPM mutation Down syndrome Bad prognostic factors: Monosomy 7 5q deletion FLT3 - internal tandom duplication