This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzymes, Subject name: Biochemistry
Which of the following is false? 
Select and explain. 
A. Cofactors have functions similar to those of prosthetic groups., B. Cofactors bind in a transient,dissociable manner to enzymes, C. The most common cofactors are metal ions, D. Enzymes that require metal ion cofactors are termed as metalloenzymes
D: Enzymes that require metal ion cofactors are termed as metalloenzymes
Answer: D: Enzymes that require metal ion cofactors are termed as metalloenzymes 
Explanation: Enzymes that require metal ion cofactor are termed metal activated enzymes,whereas enzymes for which metal ions serve as prosthetic groups are termed as metalloenzymes. If a metal is tightly bound to an enzyme(prosthetic group),it is called metalloenzyme, while an enzyme(without the metal ion)showing enhanced activity on the addition pf a metal ion(co factor)is called as metal ion activated enzyme/metal activated enzyme. Metalloenzymes:Cytochromes(Fe,Cu),aldehyde oxidase(Mo),catechol oxidasse(Cu),Carbonic anhydrase(Zn). Cofactors: A cofactor is a non protein chemical compound or metallic ion that is required for an enzymes activity. cofactor bind in a transient,dissociable manner to enzymes.Therefore,unlike associated prosthetic groups,cofactors must be present in the medium surrounding the enzyme for catalysis to occur. The most common cofactors are metal ions Reference: Harpers illustrated biochemistry 31st edition pg 58