This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
A defect in the enzyme hexosaminidase causes 
Select and explain. 
A. Gaucher disease, B. Farber disease, C. Tay-Sachs disease, D. Krabbe disease
C: Tay-Sachs disease
Answer: C: Tay-Sachs disease 
Explanation: DiseaseEnzyme DeficiencyClinical SymptomsTay-Sachs disease Hexosaminidase AMental retardation, blindness, muscular weaknessRef: Harper&;s Biochemistry; 30th edition; Chapter 24 Metabolism of Acylglycerols & Sphingolipids