This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anticoagulants and Coagulants, Subject name: Pharmacology
All of the following statements are true regarding warfarin toxicity (skin necrosis) except: 
Select and explain. 
A. Skin necrosis occurs during initiation of therapy, B. Most common sites are toes and tips of fingers, C. Decreased quantity of protein C, D. Decreased incidence of adverse effects if therapy with LMWH is started.
B: Most common sites are toes and tips of fingers
Answer: B: Most common sites are toes and tips of fingers 
Explanation: Ans. (B) Most common sites are toes and tips of fingers(Ref: Harrison 18/e p433)Common sites of warfarin-induced skin necrosis are breasts, thighs and buttocks.