This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Membranous Glomerulopathy and Membranoproliferative Glomerulopathy, Subject name: Pathology
Anti-PLA2R antibody is commonly found in which of the following renal diseases? 
Select and explain. 
A. Anti-GBM disease, B. Focal segmental glomerulosclerosis, C. Membranous nephropathy, D. Dense deposit disease
C: Membranous nephropathy
Answer: C: Membranous nephropathy 
Explanation: Antibodies against PLA2R antigen is found in most cases of primary membranous nephropathy. Anti-GBM disease: Antibodies against NC1 domain of type IV collagen antigen, cause of crescentic glomerulonephritis, linear IgG deposits along GBM in IF Dense deposit disease: Acquired or genetic dysregulation of the alternative complement pathway, C3 deposits in IF, dense deposits on electron microscopy) Focal segmental glomerulosclerosis: Cause of nephrotic syndrome, podocyte injury is implicated in pathogenesis, microscopy shows focal and segmental sclerosis and hyalinosis in the glomeruli, IgM+C3 deposits in IF