This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Defective fumarylacetoacetate hydrolase enzyme is associated with 
Select and explain. 
A. Type 1 Tyrosinemia, B. Type 2 Tyrosinemia, C. Type 3 Tyrosinemia, D. Type 4 Tyrosinemia
A: Type 1 Tyrosinemia
Answer: A: Type 1 Tyrosinemia 
Explanation: Defective fumarylacetoacetate hydrolase enzyme is associated with type I tyrosinemia (tyrosinosis). it is the most common type of tyrosinemia. Therapy employs a diet low in tyrosine and phenylalanine and nitisinone (NTBC). Reference: Harpers illustrated biochemistry 30th edition