This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Thyroid, Subject name: Surgery
The laboratory investigation of a patient shows |T4, and |TSH. Which of the following is the most likely diagnosis: 
Select and explain. 
A. Grave's disease, B. Hashimoto's disease, C. Pituitary failure, D. Hypothalamic failure
B: Hashimoto's disease
Answer: B: Hashimoto's disease 
Explanation: Grave disease is hypehyroid state,pituitary and hypothalamic failures are considered by decreased TSH. Hashimoto disease is characterised by increased TSH and decreased T4 .