This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bleeding Disorders, Subject name: Pathology
Hemophilia is associated with - 
Select and explain. 
A. X Chromosome, B. Y Chromosome, C. Chromosome 3, D. Chromosome 16
A: X Chromosome
Answer: A: X Chromosome 
Explanation: Ans. is 'a' i.e., X chromosome o Hemophilia A is caused due to defect or decrease in factor VIII.o The factor VIII gene is one of the largest genes known comprising about .l%of the X chromosome.o Factor VIII contains several areas of internal homology '.Hemophilia A geneso Hemophilic gens does not demonstrate a uniform abnormality, instead numerous different mutations in the Factor VIII gene have been described.o Seven different mutations have been demonstrated in the hemophilia gene.o Most common mutation associated with hemophilia A is major inversion of a section of the tip of the long arm of X chromosome.