This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Beta thalasemmia, Subject name: Pathology
A 32-year-old female, asymptomatic, not requiring blood transfusion, presents with Hb 13.0 gm/dl. Her HbF levels levels are 95%, Hb A2 1.5%. Which of the following is the most likely diagnosis? 
Select and explain. 
A. Hereditary persistence of fetal hemoglobin, B. Beta homozygous thalassemia, C. Thalassemia intermedia, D. Beta heterozygous thalassemia
A: Hereditary persistence of fetal hemoglobin
Answer: A: Hereditary persistence of fetal hemoglobin 
Explanation: - In given pt, even though HbF levels are elevated, these pts have normal Hb levels & asymptomatic without any requirement of any transfusions. Hence, thalassemia is ruled out - These features points towards the diagnosis of Hereditary persistence of fetal hemoglobin (HPFH) - It is benign condition in which fetal hemoglobin ( HbF) production is increased & continued into adulthood Patient remains asymptomatic even without blood transfusion No anemia; no splenomegaly