This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Tyrosinemics are more susceptible to develop: 
Select and explain. 
A. Adenocarcinoma colon, B. Melanoma, C. Retinoblastoma, D. Hepatic carcinoma
D: Hepatic carcinoma
Answer: D: Hepatic carcinoma 
Explanation: Ans:D.)Hepatic CarcinomaTyrosinemia type I, hepatocellular carcinoma occurs in children who survive beyond 2 yrs.TYROSINEMIA TYPE IThe disease is due to a deficiency in fumaryl- acetoacetate hydrolase.Accumulation of fumarylacetoacetate and its metabolites, paicularly succinyl- acetone, in the urine.Characteristic cabbage-like odor occurs.Liver failure and renal tubular acidosis result.Treatment includes dietary restriction of phenylalanine and tyrosine, and substrate restriction using nitisinone.