This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anesthesia, Subject name: Pharmacology
Local anesthetics act by: 
Select and explain. 
A. Affecting at the spinal level, B. Affecting the Na+ channels, C. Affecting the K+ channels, D. Blocking axonal transpo
B: Affecting the Na+ channels
Answer: B: Affecting the Na+ channels 
Explanation: The primary mechanism of action is by blockade of voltage gated sodium channels and block sodium entry into cell. From padmaja 4th edition Page no 200