This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2018, Subject name: Surgery
Malignancy in a multinodular goiter is most often:- 
Select and explain. 
A. Follicular carcinoma, B. Papillary carcinoma, C. Anaplastic carcinoma, D. Medullary carcinoma
A: Follicular carcinoma
Answer: A: Follicular carcinoma 
Explanation: Follicular ca: - Seen in iodine deficient areas - M/C malignancy in long standing goiter - M/c malignancy in multinodular goiter Papillary ca: - Seen in iodine sufficient areas - M/C thyroid malignancy Anaplastic ca: - Rare; m/c seen in females - Usually seen in 7th - 8th decade of life Medullary ca: - Arise from Parafollicular C cells - C cells derived from ultimobranchial bodies