This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is not a channelopathy? 
Select and explain. 
A. Cystic fibrosis, B. Liddle's syndrome, C. Tay-sach's disease, D. Hypokalemic periodic paralysis
C: Tay-sach's disease
Answer: C: Tay-sach's disease 
Explanation: Channelopathy

A channelopathy refers to a disease involving dysfunction of an ion channel.
Channelopathies are known that involve the ion channels for potassium, chloride, sodium and calcium
Ion channels serve many functions apart from electrical signal transduction: chemical signalling ( Ca 2+ as a second messenger), transepithelial transport, regulation of cytoplasmic or vesicular ion concentration and pH, and regulation of cell volume. Therefore, ion channel dysfunction can cause diseases in many tissues.