This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of these is true regarding CML - 
Select and explain. 
A. Size of splenomegaly indicates prognosis, B. Phagocytic activity of WBC is reduced, C. Sudan black stain is specific for myeloblast, D. All
A: Size of splenomegaly indicates prognosis
Answer: A: Size of splenomegaly indicates prognosis 
Explanation: Ans. is 'a' i.e., Size of splenomegaly indicates prognosis SOKAL INDEX is used for assessing the prognosis in CML. It includes 1. % of circulating blasts 3. platelet count 5. cytogenetic clonal evaluation 2. spleen size 4. age o The cytogenic hallmark of CML is presence of philadelphia chromosome (9:22). It is present in all the cell lines. Whether erythroid series, myeloid series or megakaryocytes. Also know o Other index used for assessing the prognosis of CML is HASFORD SYSTEM. It was developed based on IFN-alpha treated patients. It includes:- i) % of circulating blasts iii) Spleen size v) Age % of eosinophils & basophils iv) Platelet count