This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pathology
Acantholysis means 
Select and explain. 
A. Diffuse epidermal hyperplasia, B. Loss of intercellular connections, C. Intercellular edema of the epidermis., D. Abnormal keratinization
B: Loss of intercellular connections
Answer: B: Loss of intercellular connections 
Explanation: Answer is option 2, loss of intercellular connections We performed scanning electron microscopy of an inveed blister roof in a case of pemphigus foliaceus. The loss of intercellular adherence could be easily seen with low magnification. The acantholytic keratinocytes displayed an irregular and sometimes polygonal contour. Round cells, typically seen in light microscopy, were also observed. The examination of a blister roof allows ultrastructural documentation of the acantholytic changes.