This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
drugs with high plasma protein binding are 
Select and explain. 
A. sho duration of action, B. less drug interactions, C. lower volumes of distribution, D. all the above
C: lower volumes of distribution
Answer: C: lower volumes of distribution 
Explanation: plasma protein binding causes restriction of drugs in the vascular compament and thus lower volume of distribution