This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
First antibody to appear in blood in Acute Hepatitis B is: 
Select and explain. 
A. IgM anti-HBc, B. Anti HBs, C. Anti HBe, D. IgG anti HBc
A: IgM anti-HBc
Answer: A: IgM anti-HBc 
Explanation: IgM anti-HBc