This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Which of the following physiological changes occur during fever? 
Select and explain. 
A. Thermoregulatory centre to shift to new level, B. Resetting of skin temperature, C. Both of the above, D. None of the above
A: Thermoregulatory centre to shift to new level
Answer: A: Thermoregulatory centre to shift to new level 
Explanation: Fever is an elevation of body temperature that exceeds the normal daily variation and occurs in conjunction with an increase in the hypothalamic set point . The processes of heat conservation (vasoconstriction) and heat production (shivering and increased nonshivering thermogenesis) develops until the temperature of the blood bathing the hypothalamic neurons matches the new thermostat setting. Once that point is reached, the hypothalamus maintains the temperature at the febrile level. Ref: Dinarello C.A., Porat R. (2012). Chapter 16. Fever and Hypehermia. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.