This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
What is the pathogenetic mechanism of HPV in causing cervical carcinoma? 
Select and explain. 
A. Down regulation of 16INK4 protein, B. Degradation of cyclin D1, C. Genomic instability of E6 and E7, D. Up regulation of BCL2
C: Genomic instability of E6 and E7
Answer: C: Genomic instability of E6 and E7 
Explanation: Reference : Robbins basic pathology 9th edition : the oncogene city of HPV is related to the expression of two viral oncoproteins,E6 and E7 they bind to Rb and p53,respectively neutralizing their function