This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Pharmacology, Subject name: Pharmacology
Therapeutic index of a drug is indicative of 
Select and explain. 
A. Measure of safety, B. Measure of adverse effect, C. Dose range across which the drug can be safely administered, D. Measure of efficacy
A: Measure of safety
Answer: A: Measure of safety 
Explanation: Ans: A (Measure of safety)Ref: Thripathi 5 ed. Pg. 46Therapeutic index is a measure of drug safety.Therapeutic index (TD)It is the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response. A large value indicates that there is a wide margin between doses that are effective and doses that are toxic.TD = TD50/ED50 TD50 is the dose that produces a toxic effect in half the population.ED 50 is the dose that produces a desired effect in half the population.