This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
. Primary biliary cirrhosis is positive for 
Select and explain. 
A. PANCA, B. Anti-mitochondrial antibody, C. Anti nuclear antibody, D. Anti-microsomal antibody
B: Anti-mitochondrial antibody
Answer: B: Anti-mitochondrial antibody 
Explanation: Primary Biliary Cirrhosis(PBC) - A progressive autoimmune liver disease characterised by non suppurative, inflammatory destruction of intra hepatic bile ducts. Characteristic autoantibody detected in primary biliary cirrhosis is antimitochondrial antibody Consequences: bile duct destruction-impaired secretion of bile, cholestasis, and inflammatory reaction in the poal tract-hepatic damage, fibrosis- cirrhosis and liver failure. SYSTEMIC AND GENERAL PATHOLOGY RAMDAS NAYAK PG NO 461 IMAGE REF: