This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Malabsorbtion Syndrome, Subject name: Medicine
Alpha 1 anti -trypsin in stool is indicative of: 
Select and explain. 
A. Protein losing enteropathy, B. Chronic pancreatitis, C. Acute pancreatitis, D. Whipple disease
A: Protein losing enteropathy
Answer: A: Protein losing enteropathy 
Explanation: Alpha-1-antitrypsin (a-1-AT)- glycoprotein, which is produced by the liver, intestinal macrophages, monocytes and mucous membrane cells of the gut. Belongs acute phase proteins Lack of a-l-AT-enhanced proteolysis. . Measurement of a-1-AT in stool reflects the permeability of the gut during inflammatory processes.