This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Anti–TNF alpha drugs are used for the treatment of all of following diseases EXCEPT : 
Select and explain. 
A. Systemic lupus erythematosis, B. Seronegative arthritis, C. Psoriatic arthritis, D. Crohn's disease
A: Systemic lupus erythematosis
Answer: A: Systemic lupus erythematosis 
Explanation: There is already under-expression of TNF-α in SLE, therefore we cannot use anti-TNF drugs for this condition. It is further strengthened by the fact that anti-TNF alpha drugs like infliximab cause SLE as the adverse effect.
Indications for TNF-α inhibitors

Rheumatoid arthritis
Juvenile arthritis
Psoriatic arthritis
Psoriasis
Ankylosing spondylitis
Crohn's disease