This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Anatomy
Hereditary chronic pancreatitis is caused by mutation of 
Select and explain. 
A. Cationic trypsinogen or PRSS1, B. CFTR, C. PTSI, D. SPINK1
A: Cationic trypsinogen or PRSS1
Answer: A: Cationic trypsinogen or PRSS1 
Explanation: Hereditary pancreatitis Autosomal dominant disease Due to a missence mutation on cationic trypsinogen, or PRSS1(Protease, serine 1) results in premature, intrapancreatic activation of trypsinogen The incidence is equal in both sexes Ref: Sabiston 20th edition Pgno :1532