This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
Which is C/I in closed system anesthesiology : 
Select and explain. 
A. Methoxyflurane, B. Isoflurane, C. Sevoflurane, D. Desflurane
C: Sevoflurane
Answer: C: Sevoflurane 
Explanation: C i.e. Sevoflurane