This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Substance abuse, Subject name: Anatomy
Disulfiram is used to treat 
Select and explain. 
A. Opioid dependence, B. Alcohol dependence, C. Cocaine dependence, D. Amphetamine dependence
B: Alcohol dependence
Answer: B: Alcohol dependence 
Explanation: DISULFIRAM is a DETERRANT which acts by blocking acetaldehyde dehydrogenase When acetaldehyde dehydrogenase is blocked there will be increased amount of acetaldehyde that acts on mast cells and results in release of histamine that in turn leads to allergic reaction. Thus when a patient on disulfiram takes alcohol there would be allergic reaction that prevents the patient from using the substance Ref.Kaplon and Sadock, synopsis of Psychiatry, 11 th edition, pg No.625