This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacterial infections, Subject name: Dental
Earliest sensation lost in leprosy is 
Select and explain. 
A. Thermal, B. Tactile, C. Pain, D. Vibration
A: Thermal
Answer: A: Thermal 
Explanation: The earliest manifestation of leprosy is the involvement of the cutaneous nerve, resulting in a loss of thermal sensation as the initial deficit and then evolving to involve other modalities like pain and touch. Sensory modalities subserved by larger fibers are lost in more advanced stages of the disease. Ref Harrison20th edition pg 1335