This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous System, Subject name: Pathology
Hirano bodies seen in? 
Select and explain. 
A. Rabbies, B. Alzheimer's disease, C. Pick's disease, D. Viral encephalitis
B: Alzheimer's disease
Answer: B: Alzheimer's disease 
Explanation: Ans. is 'b' i.e., Alzheimer's disease Hirano bodies* They are intracellular, paracrystalline, eosinophilic structures often occurring as rod shapes in the neurons of individuals with neuro-degenerative diseases including Alzheimer's and some forms of Creutzfeldt-Jacob disease. They are intracellular aggregates of actin and actin-associated proteins* Most often encountered in neurons of the central nervous system in the neuronal processes in the pyramidal layer in the Sommers sector (CA1) of the hippocampus.