This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
A vasopressin analogue does not produce therapeutic effect through vasopressin V-2 receptor in which of the following - 
Select and explain. 
A. Central diabetes insipidus, B. Bleeding esophageal varices, C. Type 1 van Willebrand's disease, D. Primary nocturnal enuresis
B: Bleeding esophageal varices
Answer: B: Bleeding esophageal varices 
Explanation: Ans is option 2 bleeding esophageal varices Vasopressin stops bleeding of esophageal varices by constricting the vessels through V1 receptors. All other act through V2 receptors on kidney liver and vascular endothelium V 1 receptors are present on blood vessels smooth muscles CNS platelet etc.. Ref.. KDT 4/e p 539-541