This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cailage tissue & cell junctions, Subject name: Anatomy
Which one of the following makes epiphyseal cailage matrix fail to calcify? 
Select and explain. 
A. Thyroxine, B. Hypervitaminosis A, C. Hypovitaminosis D, D. Hydrocoisone
C: Hypovitaminosis D
Answer: C: Hypovitaminosis D 
Explanation: In the absence of vitamin D, epiphyseal chondrocytes continue to proliferate, but their matrix does not calcify, which leads to rickets.