This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
Which of the follwing statements regarding drugs used in leprosy is FALSE? 
Select and explain. 
A. Single intramuscular injections of acedapsone maintain inhibitory levels of dapsone in tissues for upto 3 months, B. Monthly doses of rifampicin delay the emergence of resistance to dapsone, C. Clofazimine should not be given to patients who are intolerant to dapsone or who fail to improve during treatment with dapsone, D. Clofazimine may cause changes in the skin colour
C: Clofazimine should not be given to patients who are intolerant to dapsone or who fail to improve during treatment with dapsone
Answer: C: Clofazimine should not be given to patients who are intolerant to dapsone or who fail to improve during treatment with dapsone 
Explanation: (Ref: KDT 6/e p752, 753) Acedapsone is a repository form od dapsone. Single i,m. injection of acedapsone keep on releasing the drug for 3 months. Rifampicin is used once in a month (supervised dose) for the treatment of leprosy. It prevents the emergence of resistance to dapose. Clofazimine can result in skin pigmentation, disclolouration of secretions and dryness of skin (icthyosis). Clofazimine has no cross-allergenicity with dapsone.