This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autoimmune Skin Disorders, Subject name: Skin
A 2 year old born out of consanguineous marriage, had a history of the collodion membrane. He had large, thick, plate-like brown scaling generalized distribution; no erythroderma and ectropion. Which disease is it? 
Select and explain. 
A. Ichthyosis vulgaris, B. Lamellar ichthyosis, C. X linked ichthyosis, D. Netherton syndrome
B: Lamellar ichthyosis
Answer: B: Lamellar ichthyosis 
Explanation: Ans. B. Lamellar ichthyosisLamellar ichthyosis (LI)* Collodion baby at birth as the baby is covered by a thickened collodion-like membrane which is then shed* Scaling occurs over the whole body, including creases and bends* The scale in LI is typically large, dark brown or grey and firmly adherent* Drooping of lower eyelids (ectropion), palmoplantar keratoderma and scarring alopecia may be seen in severe cases.* Limitation of joint movement, flexion contractures, and digital sclerodactyly may result. Nails may be small but hair shaft, mucous membranes and teeth are not affected.* May be associated with a mutation in transglutaminase 1 gene.