This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Endocrine), Subject name: Pathology
Which of the following is not a feature of Sipple syndrome? 
Select and explain. 
A. Pheochromocytoma, B. Medullary carcinoma thyroid, C. Hyperthyroidism, D. Hyperparathyroidism
C: Hyperthyroidism
Answer: C: Hyperthyroidism 
Explanation: Ans. is 'c' i.e., Hyperthyroidism Multiple endocrine neoplasia (MEN)1) MEN-1 (Wermer syndrome)# It involves primarily three glandsa) Parathyroid (parathyroid hyperplasia/adenoma): Most common manifestation.b) Pituitary: Prolactinoma is the most common type of pituitary tumor in MEN-I.c) Pancreas: There is let cell hyperplasia/adenoma.# Less common findings are pheochromocytoma, foregut carcinoid, lipomas and dermal angiofibroma.2) MEN-IIA (sipples syndrome)# It consists of medullary carcinoma thyroid, parathyroid hyperplasia/adenoma and pheochromocytoma of adrenal medulla.3) MEN-1IB# It consists of medullary carcinoma thyroid, pheochromocytoma, GIT neuromas and marfanoid features.