This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: ENT
Choanal atresia is associated with which syndrome: 
Select and explain. 
A. VACTERL, B. CHARGE, C. APECED, D. LEOPARD
B: CHARGE
Answer: B: CHARGE 
Explanation: Most cases of choanal atresia are sporadic, although familial cases suggest autosomal dominant or autosomal recessive modes of a single gene defect. Approximately one-half to two-thirds of patients with choanal atresia have associated malformations, which occur more frequently with bilateral atresia. The most common of these is the CHARGE association: Coloboma of the eye Hea malformations Choanal Atresia Retarded growth, development, or both Genital hypoplasia Ear malformations, deafness, or both