This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
HPV causes which change in cervical epithelium ? 
Select and explain. 
A. Induction of apoptosis, B. Induction of necrosis, C. Immoalization of epithelial cells, D. By stimulating telomerase
C: Immoalization of epithelial cells
Answer: C: Immoalization of epithelial cells 
Explanation: Ans. is 'c' i.e., Immoalization of epithelial cells HPV selectively infects the epithelium of skin and mucous membrane and may immoalize the keratinocytes leading either asymptomatic infection, or was or neoplasia.Products of E-genes (E6, E7) are related to immoalization or malignant transformation of keratinocytes by interfering with p53 and Rb genes, respectively.