This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hodgkin's Lymphoma, Subject name: Pathology
Which of the following subtype has the strongest association with HIV in Hodgkin lymphoma ? 
Select and explain. 
A. Lymphocyte-rich, B. Lymphocyte-depleted, C. Nodular lymphocyte-predominant, D. Nodular sclerosis
B: Lymphocyte-depleted
Answer: B: Lymphocyte-depleted 
Explanation: Lymphocyte-depleted Hodgkin lymphoma : It has the strongest association with the HIV. Lymphocyte depletion Hodgkin lymphoma occurs predominantly in older adults, in HIV-positive individuals of any age Least common subtype of HL Diffuse subtype of classic Hodgkin lymphoma (CHL) rich in Hodgkin Reed-Sternberg (HRS) cells or depleted in non-neoplastic lymphocytes. Advanced stage and systemic symptoms are frequent Worst Prognosis.