This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc. (R.B.C), Subject name: Pathology
Most common mutation in hereditary spherocytosis 
Select and explain. 
A. Spectrin, B. Ankyrin, C. Glycophorin A, D. Band 3
B: Ankyrin
Answer: B: Ankyrin 
Explanation: Ans. (b) Ankyrin(Ref: Robbins 9th/pg 632; 8th/pg 642)Most common mutation:Hereditary spherocytosis is Ankyrin>Band-3>spectrinHereditary elliptocytosis is Spectrin