This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Which of the following statements are true regarding benzodiazepines? 
Select and explain. 
A. It acts as GABA agonist, B. Diazepam is a sho acting benzodiazepines, C. Diazepam causes lesser respiratory depression than midazolam, D. Nitrazepam is metabolized in liver
C: Diazepam causes lesser respiratory depression than midazolam
Answer: C: Diazepam causes lesser respiratory depression than midazolam 
Explanation: Benzodiazepines act on BZD receptors of GABAA-BZD receptor-chloride channel complex and increase the frequency of CI -channel opening GABA facilitatory action. Thus these are not GABA agonists. Coma, respiratory depression though rare,can occur with ultra sho acting agents like midazolam,thriazolam. Diazolam has rapid onset of action but prolonged action due to formation of active metabolized. Ref: KD Tripathi 8th ed.