This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Increased Nuchal Translucency at 14 weeks gestation is seen in: 
Select and explain. 
A. Turner's syndrome, B. Down's syndrome, C. Hydrocephalus, D. Skeletal Dysplasia
B: Down's syndrome
Answer: B: Down's syndrome 
Explanation: Increased nuchal translucency at 11-14 weeks of gestation is seen most commonly in trisomies. Many component proteins of extracellular matrix are encoded on chromosome 13,18,21. Altered composition of extracellular matrix account for the increased nuchal translucency in the trisomies of these chromosomes. Ref: William's Obstetrics, 23rd Edition, Pages 295, 351; Donald School Textbook of Ultrasound in Obstetics and Gynecology, 2nd Edition, Pages 183, 184; Ultrasound in Obstetrics and Gynaecology By Merz and Bohimann, 2nd Edition, Page 11; Diagnostic Imaging of Fetal Anomalies By David A. Nyberg, John P. McGahan, Pages 845-8.