This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lymphoma and Plasma cell disorder, Subject name: Medicine
Reed Sternberg cells are: 
Select and explain. 
A. B cells, B. T cells, C. Natural killer cells, D. All of above
A: B cells
Answer: A: B cells 
Explanation: Reed-Sternberg (RS) cells are the malignant cells in Hodgkin Lymphoma which is a malignancy of germinal center mature B lymphocytes. These are large cells with abundant cytoplasm with bilobed and/or multiple nuclei These comprise less than 1% of the cellular infiltrate in the lymphoma tissue.