This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Fungal Drugs, Subject name: Pharmacology
If amphotericin B is administered, the patient should not be premedicated with: 
Select and explain. 
A. Diphenhydramine, B. Ibuprofen, C. Prednisone, D. Atazanavir
D: Atazanavir
Answer: D: Atazanavir 
Explanation: Amphotericin B infusion is associated with Acute Reaction which consists of chills, fever, aches and pain all over, nausea, vomiting and dyspnoea lasting for 2- 5 hour, probably due to release of cytokines (IL, TNFa). Therefore to prevent this reaction, patient should be premedicated with: H1 antihistaminics like diphenhydramine NSAIDs like ibuprofen Steroids like prednisone