This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
In multiple myeloma following are seen -( 
Select and explain. 
A. Increase Calcium, B. Bone pain, C. Renal failure, D. All of the above
A: Increase Calcium
Answer: A: Increase Calcium 
Explanation: In multiple myeloma ,hypercalcemia occurs due to destruction of bone. Bone pain is the most common symptom.The pain usually involves the back & ribs. Pathological fracture may occur causing localised pain.Bone pain results from the proliferation of tumour cells in the marrow & activation of osteoclasts which destroy the bone. Renal failure occurs due to hypercalcaemia, glomerular deposits of amyloid,hyperuricaemia, & infiltration of kidney by myeloma cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 383.