This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics And Genetic Disorders, Subject name: Pediatrics
Most common CVS lesion in Down syndrome is: 
Select and explain. 
A. VSD, B. Endocardial cushion defect, C. TOF, D. COA
B: Endocardial cushion defect
Answer: B: Endocardial cushion defect 
Explanation: b. Endocardial cushion defect(Ref: Nelson's 20/e p 610-615, Ghai 8/e p 637-639)Most common cardiac defect in Down syndrome is Endocardial cushion defect or Atrioventricular septal defect