This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Interstitial lung diseases, Subject name: Pathology
All of the following statement are true regarding asbestosis except: 
Select and explain. 
A. Amphiboles are more pathogenic, B. It begins in a upper zone, C. Can cause mesothelioma, D. Pulmonary hypeension may be seen
B: It begins in a upper zone
Answer: B: It begins in a upper zone 
Explanation: Asbestosis exists in 2 diff forms: - 1. Amphibole - it is straight fiber - goes directly into lungs 2. Chrysotile - Serpentile Appearance - gets trap in upper airway Asbestosis is heavy paicle, therefore disease begins with the base of the lung. Mesothelioma is most specific Carcinoma associated with asbestosis M/C Ca associated - Bronchogenic Ca Initial manifestation - Pleural plaques then fibrosis