This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anesthesia for Kidney Disease, Subject name: Anaesthesia
Which of the following is nephrotoxic - 
Select and explain. 
A. Halothane, B. Methoxyflurane, C. Ether, D. Cyclopropane
B: Methoxyflurane
Answer: B: Methoxyflurane 
Explanation: Ans. is 'b' i.e., Methoxyflurane o Intrarenal metabolism of methoxyflurane and subseuent intrarenal production offlouride ion is the significant cause of methoxyflurane renal toxicity.o It can cause high output renal failure.o It was the most potent inhalation agent (least MAC), but not used now (now Halothane is most potent).o It should not be used in closed circuit (reacts with rubber tubing of the closed circuit).