This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pathology
Which of the following is not true about chromothrypsis? 
Select and explain. 
A. It is associated with chromosome rearrangements termed as chromosome shattering., B. It is observed in 1% to 2% of cancers as a whole., C. Associated with inactivation of oncogenes and activation of tumor suppressors., D. Increased frequency of 25% of osteosarcomas and high frequency in gliomas
C: Associated with inactivation of oncogenes and activation of tumor suppressors.
Answer: C: Associated with inactivation of oncogenes and activation of tumor suppressors. 
Explanation: Chromothrypsis Phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localized and confined genomic regions Involved in cancer (1% -2%)and congenital diseases. Osteosarcomas and gliomas as well. Chromosome breaks occur within pa or across the entirety of a single chromosome or several chromosomes. Activate oncogenes and inactivate tumor suppressors, thereby expediting the process of carcinogenesis.