This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Which of the following is NOT a cause of congenital hypercoagulability aEUR' 
Select and explain. 
A. Protein C deficiency, B. Protein S deficiency, C. Antiphospholipid antibody syndrome, D. MTHFR gene mutations
C: Antiphospholipid antibody syndrome
Answer: C: Antiphospholipid antibody syndrome 
Explanation: Antiphospholipid antibody syndrome Congenital Factor V Leiden (5% of the population are heterozygous for FVL). Prothrombin mutation (G20210A, 5'UTR). High homocysteine levels due to MTHFR mutation Sickle-cell disease (only small risk) Antithrombin III deficiency. Protein C deficiency. Protein S deficiency. Plasminogen and fibrinolysis disorders (very rare) Acquired Antiphospholipid antibodies - Anti-cardiolipin antibodies and/or - Lupus anticoagulants Heparin-induced thrombocytopenia Paroxysmal nocturnal hemoglobinuria Nephrotic syndrome Hyperestrogenemia Estrogen-containing honnonal contraceptives Tobacco smoking Hyperhomocysteinemia due to vitamin B12 and folic acid deficiency