This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Hypercoagulation in nephrotic syndrome is caused by? 
Select and explain. 
A. Loss of antithrombin III, B. Decreased fibrinogen, C. Decreased metabolism of Vitamin K, D. Increase in protein C
A: Loss of antithrombin III
Answer: A: Loss of antithrombin III 
Explanation: Ans. is 'a' i.e., Loss of antithrombin III Causes of Hypercoagulability in nephrotic syndrome o Loss of antithrombin III o Increased synthesis of fibrinogen by liver. o Altered activity of protein C and S o Increased platelet aggregability. o Hypercoagulability can cause renal vein thrombosis.