This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Chronic recurrent synovitis with history of pustules in multiple sites diagnostic of ? 
Select and explain. 
A. Werner’s syndrome, B. Wartenberg’s syndrome, C. SAPHO syndrome, D. Wermer syndrome
C: SAPHO syndrome
Answer: C: SAPHO syndrome 
Explanation: Ref. Textbook of Orthopedics, Ebnezar. Page. 688
 
SAPHO Syndrome

SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints.
SAPHO is an acronym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis.
Genetic predisposition is suggested by the higher prevalence of HLA-B27
There is no specific treatment – Supportive care only.