This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
Which of the following drugs require dose adjustment in renal failure? 
Select and explain. 
A. Cefoperazone, B. Doxycycline, C. Streptomycin, D. Rifampicin
C: Streptomycin
Answer: C: Streptomycin 
Explanation: Reduce dose even in mild failure :Aminoglycosides, Amphotericin B ,Ethambutol ,Vancomycin Flucytosine Reduce dose only in moderate-severe failure Metronidazole, Carbenicillin ,Cotrimoxazole Aztreonam, Meropenem ,Fluoroquinolones Clarithromycin ,Imipenem Drugs to be avoided: Cephalothin ,Talampicillin ,Nalidixic acid, Tetracyclines ,Nitrofurantoin (except doxycycline) ESSENTIALS OF MEDICAL PHARMACOLOGY page no.695