This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and Reproduction, Subject name: Physiology
Excess secretion of aldosterone causes all except: 
Select and explain. 
A. Increased ECF, B. Very High Na+ in plasma, C. Increased BP, D. Natriuresis
B: Very High Na+ in plasma
Answer: B: Very High Na+ in plasma 
Explanation: Ans. (b) Very High Na+ in plasma(Ref: Ganong, 25th ed/p.370)Excess aldosterone causes Sodium and water retentionIn spite of action of aldosterone on the renal tubules, Sodium excretion is increased during aldosterone excess - "Aldosterone Escape phenomenon"This is because of the increase in atrial natriuretic peptide (ANP) secretion that excretes sodium in response to increase in ECF volumeSo, Very High Na+ in plasma is not seen in aldosterone excess