This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
The marker for determining efficacy of hepatitis B vaccination is: 
Select and explain. 
A. HBs Ag, B. IgM Anti HBc, C. IgG Anti HBc, D. Anti - HBs Ag
D: Anti - HBs Ag
Answer: D: Anti - HBs Ag 
Explanation: Answer is D (Anti-HBs Ag) Anti-HBsAg is the only serological marker to appear after immunization with hepatitis vaccine. Diagnostic interpretation Hbs Ag Anti Hbs Anti HBc Hbc Ag Anti Hbe Immunization with Hbs Ag - + - - - (? Hepatitis B is remote past) (? False positive) Isolated Anti-HBs Ag in serum is seen in immunization with HBs Ag. Possible Causes of Isolated Anti-HBsAg Positivity in serum (Other markers negative hnnumization with 11BsAg (after vaccination) Hepatitis B in the remote past (?) False-positive