This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pituitary, Subject name: Physiology
Growth hormone has its effect on growth through- 
Select and explain. 
A. Directly, B. IGF -1, C. Thyroxine, D. Intranuclear receptors
B: IGF -1
Answer: B: IGF -1 
Explanation: Ans. is 'b' i.e., IGF -1 o GH has two major functions:- The growth of skeletal system The growth is mediated by somatomedins (IGF). Increased deposition of cartilage (including chondroitin sulfate) and bone with increased proliferation of chondrocytes and osteocytes. Metabolic effects- most of the metabolic effects are due to the direct action of GH. These include gluconeogenesis, decreased peripheral utilization of glucose (decreased uptake), lipolysis and anabolic effect on proteins.