This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNB 2018, Subject name: Pharmacology
The use of levodopa is avoided in which of the following patients? 
Select and explain. 
A. Alzheimer's disease, B. Psychosis, C. Multiple sclerosis, D. Amyotrophic lateral sclerosis
B: Psychosis
Answer: B: Psychosis 
Explanation: Any drug which increase dopamine in brain causes psychosis.Levodopa should be avoided in patient with psychosis Anti parkinsonism drug can cause psychosis Anti Psychotic drug can cause parkinsonism Multiple sclerosis : Interferon b1a and interferon b1b: The immunomodulatory effects of interferon help to diminish the inflammatory responses that lead to demyelination of the axon sheaths. Glatiramer: Glatiramer is a synthetic polypeptide that resembles myelin protein and may act as a decoy to T-cell attack. Natalizumab: Natalizumab is a monoclonal antibody indicated for MS in patients who have failed first-line therapies.