This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Bleeding disorders with it APTT andt PT: 
Select and explain. 
A. Factor 13 deficiency, B. Severe liver disease, C. Immune thrombocytopenic purpura, D. Leiden (Factor V) deficiency
B: Severe liver disease
Answer: B: Severe liver disease 
Explanation: Answer is option 2, severe liver disease Liver disease is associated with impairment of the haemostatic function due to the abnormal and decreased synthesis of the clotting factors. It is thus only logical to have considered assessment of the clotting profile (to include prothrombin time (PT) and activated paial thromboplastin time (aPTT)) to be an integral pa of the comprehensive assessment of a patient who presents with liver impairment. Laboratory abnormalities of coagulation are considered to be a predictive risk factor for bleeding, but patients with liver disease do not have bleeding pattern as those who have coagulation factor deficiencies. Ref Robbins 9/e pg 450