This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemical Mediators and Regulators of Inflammation, Subject name: Pathology
IL-1 is the principle chemical mediator of - 
Select and explain. 
A. Fever, B. Itching, C. Vasoconstriction, D. Chemotaxis
A: Fever
Answer: A: Fever 
Explanation: Ans. is 'a' i.e., Fever "IL-l and TNF-a are the two most important pyrogenes " -- Physiology basics.