This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
Osmotic fragility is increased in - 
Select and explain. 
A. Sickle cell anaemia, B. Thalassemia, C. Hereditary spherocytosis, D. Chronic lead poisoning
C: Hereditary spherocytosis
Answer: C: Hereditary spherocytosis 
Explanation: <p>Osmotic fragility test is helpful in testing the spheroidal nature of red cells which readily lyse more readily in solutions of low salt concentration that is osmotic fagility is increased in hereditary spherocytosis. </p><p>Harsh mohan textbook of pathology 6th edition pg no 315</p>