This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: A.N.S., Subject name: Pharmacology
Antidote for belladonna poisoning: 
Select and explain. 
A. Neostigmine, B. Physostigmine, C. Pilocarpine, D. Methacholine
B: Physostigmine
Answer: B: Physostigmine 
Explanation: Ans. B. PhysostigmineBeing tertiary amine, Physostigmine can reverse the CNS manifestation of belladonna poisoning. Whereas neostigmine has very less CNS penetration.