This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Bleeding disorders with T APTT and 1st PT: 
Select and explain. 
A. Factor 13 deficiency, B. Severe liver disease, C. Immune thrombocytopenic purpura, D. All
B: Severe liver disease
Answer: B: Severe liver disease 
Explanation: Ans. is 'b' i.e., Severe liver disease o Prothrombin time assesses factor V, VII, X & II ; all of which are synthesized in liver. o PTT assess measures activity of factor V, VIII, IX, X, XI, XII & II some of which (II, VIII, VII, X, V) are synthesized in liver. So, in liver diseases both aPTT as well as PT are increased. In immune thrombocytopenia, there is increased BT due to platelet defect.