This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical, surgical and gynaecological illness complicating pregnancy, Subject name: Gynaecology & Obstetrics
Effect of PIH on GFR is: 
Select and explain. 
A. GFR Increase, B. Decreases GFR, C. GFR remains the same, D. GFR can increase or decrease
B: Decreases GFR
Answer: B: Decreases GFR 
Explanation: The changes are conspicous in the glomerulus which becomes enlarged.(Glomerular Endotheliosis) Endothelial cells swell up and fibrin like deposits occur in the basement membrane. Lumen may be occluded. Interstitial cells between the capillaries proliferate. There is associated spasm of the afferent glomerular aerioles. Patchy areas of damage of the tubular epithelium due to anoxia are evident. Net effects are reduced Renal blood flow and glomerular filtration rate(25%) and impare tubular reabsorption or secretory function. Reference: Textbook of Duttas,9th edition, page 209.