This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation & Repair, Subject name: Pathology
Which of the following is the chief mediator associated with resetting the hypothalamic temperature set point at a higher level, resulting in fever? 
Select and explain. 
A. PGF2 alpha, B. PGE1, C. PGE2, D. PGI2
C: PGE2
Answer: C: PGE2 
Explanation: Ans. (c) PGE2(Ref: Robbins 9th/pg 99)The increase in body temperature is caused by prostaglandins that are produced in the vascular and perivascular cells of the hypothalamus.In the hypothalamus, the prostaglandins, especially PGE2, stimulate the production of neurotransmitters that reset the temperature set point at a higher level.