This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Hormone replacement therapy in postmenopausal women can aggravate: 
Select and explain. 
A. Osteoporosis, B. Migraine, C. Hot flushes, D. All of the above
B: Migraine
Answer: B: Migraine 
Explanation: None