This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Amyloidosis is most commonly seen in ? 
Select and explain. 
A. Maturity onset DM, B. Type I DM, C. Type H DM, D. HTN
C: Type H DM
Answer: C: Type H DM 
Explanation: Ans. is 'c' i.e., Type II DMo The two best examples of localized amyloidosis are Alzheimer's disease and type 2 diabetes mellitus.o Localized amyloid deposition results from the production of a unique polypeptide, which contains an amyloidogenicsequence and is capable of forming a beta-pleated sheet structure necessary for these deposits to aggregate. o In type 2 diabetes it is the islet amyloid polypeptide (IAPP) also known as amylin.o In Alzheimer's the unique peptide is the beta-amyloid protein (A beta).