This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General physiology, Subject name: Physiology
Oxidative or Respiratory burst phenomenon? 
Select and explain. 
A. Due to antimicrobial proteins called defensins, B. Occurs during diapedesis, C. Activation of NADPH oxidase associated with increase in oxygen uptake and metabolism in neutrophils, D. Production of HOCl, HOBr from Cl-, Br- respectively by the action of myeloperoxidase
C: Activation of NADPH oxidase associated with increase in oxygen uptake and metabolism in neutrophils
Answer: C: Activation of NADPH oxidase associated with increase in oxygen uptake and metabolism in neutrophils 
Explanation: Activation of NADPH oxidase is associated with a sharp increase in O2 uptake and metabolism in the neutrophil (the respiratory burst) and generation of O2- by the following reaction: NADPH + H++ 2O2+ - NADP++ 2H++ 2O2- Reference: Ganong's Review of Medical Physiology; 25th edition; Page no: 68