This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diet in Pregnancy, Subject name: Gynaecology & Obstetrics
Neural tube defect is due to deficiency of - 
Select and explain. 
A. Folate, B. Pyruvate, C. Cobalamine, D. Thiamine
A: Folate
Answer: A: Folate 
Explanation: Ans. is 'a' i.e.. Folate "Folic acid supplementation can reduce the risk of NTDs, presumably by preventing nutritional deficiency and by overcoming disruptions in folate metabolism related to underlying genetic variation in folate-related genes. Folic acid may enhance cell proliferation for neural closure directly or it may be involved in the epigenetic regulation of expression of genes that control neural closure."