This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Respiratory system, Subject name: Pathology
The most common paraneoplastic syndrome associated with lung cancer? 
Select and explain. 
A. SIADH, B. Cushings syndrome, C. Hypercalcemia, D. Polycythemia
C: Hypercalcemia
Answer: C: Hypercalcemia 
Explanation: *Most common paraneoplastic syndrome: Hypercalcemia *Most common endocrinopathy in paraneoplastic syndrome: Cushing syndrome*Most common carcinoma associated with Cushing syndrome: Lung carcinoma*The cancer patients develop Cushing syndrome due to excess production of pro-opiomelanocoin and coicotrophin.*Most common paraneoplastic syndrome in squamous cell lung carcinoma: Hypercalcemia*Most common paraneoplastic syndrome in small cell lung carcinoma: SIADH*Since among all lung cancers, squamous cell carcinoma is common than small cell carcinoma, Most common paraneoplastic syndrome in lung cancer is HypercalcemiaRef: Robbins 8/e p321