This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Rectum and anal canal, Subject name: Surgery
A patient of rectal carcinoma found to have tumor invading through the muscularis propria into the perirectal tissues, and two enlarged lymph nodes. How will you manage the patient? 
Select and explain. 
A. Surgery only, B. Surgery + Adjuvant chemotherapy, C. Preoperative chemoradiation followed by surgical resection, D. Palliative chemoradiation
C: Preoperative chemoradiation followed by surgical resection
Answer: C: Preoperative chemoradiation followed by surgical resection 
Explanation: Stage of rectal cancer in the given scenario- Tumor invading through the muscularis propria into the perirectal tissues- T3 Two enlarged lymph nodes- N1b Thus, making it stage 3 Management of rectal cancer according to its stage- Stage Management Tis Polypectomy I Segmental resection II Neoadjuvant chemotherapy followed by surgical resection III Preoperative chemoradiation followed by surgical resection IV Palliation, metastatectomy