This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
All are true about ramelteon except 
Select and explain. 
A. Agonist at MT1 and MT2 receptors, B. Is a substrate of CYP1A2, C. Has high addiction liability, D. Approved for treatment of insomnia
C: Has high addiction liability
Answer: C: Has high addiction liability 
Explanation: All are true for ramelteon except the statement that it has high addiction liability, in clinical trials on chronic insomnia patients, continuous nightly treatment with ramelteon maintained its effect to shoen sleep latency & was found to be free of rebound phenomenon on stoppage .No dependence producing potential has been noted so far. Ref KD Tripathi 8th ed.