This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
Neurotransmitter in mania - 
Select and explain. 
A. Increased dopaine, B. Decreased dopamine, C. Increased norepinephrine, D. Decreased norepinephrine
C: Increased norepinephrine
Answer: C: Increased norepinephrine 
Explanation: Ans. is 'c' i.e., Increased norepinephrine Neurotransmitters in mood disorders Most accepted biochemical hypothesis for mood disorders is the monoamine hypothesis, according to which serotinin and norepinephrine are the major neurotransmitters involved in mood disorders : - Depression --> Decrease in serotonin and norepinephrine. Serotonin is the most impoant neurotransmitter in depression. Mania --> Increased level of norepinephrine Patients suffering from severe depression with suicidal intent/attempt appear to have a marked decrease in serotinin. Acetylcholine and GABA are the other neurotransmitters which are involved in mood disorders.