This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Granuloma is characterized by all of the following except: 
Select and explain. 
A. A specific type of chronic inflammation, B. Accumulation of modified macrophages, C. Initiated by a number of infectious and non infectious agents, D. A reaction of acute inflammation
D: A reaction of acute inflammation
Answer: D: A reaction of acute inflammation 
Explanation: None