This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
True regarding Oncogenes are all except ? 
Select and explain. 
A. Derived from protooncogenes, B. Oncogenes code for specific protein, C. Causes in vitro cell variation in animals, D. Multiple growth factors govern the gene
D: Multiple growth factors govern the gene
Answer: D: Multiple growth factors govern the gene 
Explanation: Protooncogenes o These are physiological regulator of cell proliferation ando They act under proper physiological stimuli.o Without physiological stimuli they will be silent and there will be no replication.Oncogenes When, due to any cause (mutation or overexpression), protooncogenes become autonomous, i.e. they promote cell growth without any physiological stimulus.So, oncogenes is derived from protoncogens.o Infact oncogene and protooncogene is the same, in normal cell it acts as protooncogen while in cancer cell it acts as oncogene.Oncoproteins o Oncogenes encode proteins called Oncoproteins which resemble the normal products of protoncogenes with the exception that ?(a) Oncoproteins are devoid of impoant regulatory elements.(b) Their production in the transformed cells does not depend on growth factors or other external signals.Proto-oncogenes (Normal genes required for cell proliferation and differentiation) Oncogenes (Genes promoting autonomous cell growth in cancer cells) Oncoproteins (Proteins lacking regulatory control and responsible for promoting cell growth)