This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S, Subject name: Pharmacology
Mechanism of action of SSRI: 
Select and explain. 
A. Inhibit the reuptake of norepinephrine, B. Inhibit the reuptake of norepinephrine and serotonin, C. Inhibit the reuptake of dopamine, D. Inhibit the reuptake of serotonin
D: Inhibit the reuptake of serotonin
Answer: D: Inhibit the reuptake of serotonin 
Explanation: Ans. D. Inhibit the reuptake of serotoninAs the name suggest SSRI selectively inhibit the reuptake of serotonin. They lack anticholinergic and alpha blocking properties. They are the first choice of OCD, depression, phobia, panic and PTSD. Unlike TCA, they don't cause sedation or weight gain.