This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Duke's stage C2 refers to carcinoma - 
Select and explain. 
A. Bladder penetrating the extravesical fat, B. Bladder with metastasis to internal iliac lymph nodes, C. With histological features of 75% anaplastic cells, D. Rectum with metastasis to inferior mesentric lymph nodes
D: Rectum with metastasis to inferior mesentric lymph nodes
Answer: D: Rectum with metastasis to inferior mesentric lymph nodes 
Explanation: Duke's staging is used for colorectal cancer.
In Dukes 'C' stage, there is involvement of regional lymphnodes.
Duke's staging has been explained earlier.