This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Obs), Subject name: Gynaecology & Obstetrics
If given in 1st trimester of pregnancy Warfarin therapy leads to which problem? 
Select and explain. 
A. Chondrodysplasia, B. Fetal optic atrophy, C. Mental retardation, D. None of the above
A: Chondrodysplasia
Answer: A: Chondrodysplasia 
Explanation: Ans. A. ChondrodysplasiaWarfarin therapy is contraindicated in the first trimester due to its association with fetal chondrodysplasia punctata. In the second and third trimesters, warfarin may cause fetal optic atrophy and mental retardation.