This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mood Disorders, Subject name: Psychiatry
Which of the following medication is least effective against depression? 
Select and explain. 
A. Valproate, B. Lamotrigine, C. Lithium, D. Aripiprazole
A: Valproate
Answer: A: Valproate 
Explanation: Valproate Antiseizure drug In addition, it is used as a mood stabilizer in bipolar disorder and as prophylactic treatment for migraine. Least effective against depression Treatment : Pharmcotherapy- TCAs SSRI(M.C.) SNRI MAO inhibitors Atypical antidepressants Psychotherapy ECT