This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Structure and function of protein, Subject name: Biochemistry
In Gaucher&;s disease, there is a deficiency of 
Select and explain. 
A. Glucocerebrosides, B. glucokinase, C. Sphingomyelinase, D. G-6PD
A: Glucocerebrosides
Answer: A: Glucocerebrosides 
Explanation: Due to deficiency of glucocerebrosidase, causes glucosylceramide accumulation in macrophages called Gaucher&;s cells.DiseaseEnzyme DeficiencyClinical SymptomsGaucher diseaseb-GlucosidaseEnlarged liver and spleen, erosion of long bones,mental retardation in infantsRef: Harper&;s biochemistry; 30th edition; Chapter 24 Metabolism of Acylglycerols & Sphingolipids