This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Histo Pathology, Subject name: Pathology
Most significant contraindication for Fine Needle Aspiration biopsy (FNA) is: 
Select and explain. 
A. Moribund state of the patient, B. Disseminated malignancy, C. Bleeding disorder, D. HIV positivity
C: Bleeding disorder
Answer: C: Bleeding disorder 
Explanation: Ans: c. (Bleeding disorder)Ref: British Society for Clinical CytologyContraindication for FNA1. Uncorrected coagulopathies Anticoagulant therapy Intrinsic bleeding disorder2. Parasitic cysts - Chance of anaphylactic shock.3. Cough & respiratory infection - Contraindication for transthoracic FNA4. Carotid body tumour - May cause catecholamine release with potential risk of hypertensive crisis.