This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nephrotic and Nephritic syndrome, Subject name: Medicine
Which investigation should be done for diagnosis of idiopathic membranous glomerulopathy? 
Select and explain. 
A. Antibody to PLA2R on podocytes, B. Kidney biopsy with immunofluorescent staining, C. C3, C4 and CH50 levels, D. c-ANCA titers
A: Antibody to PLA2R on podocytes
Answer: A: Antibody to PLA2R on podocytes 
Explanation: Membranous Glomerulopathy associate with Malignancy The anti-PLA2R antibody (Anti-phospholipase A2 Receptor antibody) attaches to the phospholipase A2 receptor (the antigen). The phospholipase A2 receptor is a protein found in the kidney filter (glomerulus), specifically within a cell called the podocyte which makes up pa of this filter Diagnosed by- protein in the urine and kidney biopsy