This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
Fluconazole is more effective than itraconazole in the following systemic fungal disease 
Select and explain. 
A. Pulmonary histoplasmosis, B. Cryptococcal meningitis, C. Non-meningeal blastomycosis, D. Disseminated sporotrichosis
B: Cryptococcal meningitis
Answer: B: Cryptococcal meningitis 
Explanation: Ref-KDT 6/e p763,764 Fluconazole has maximum CNS penetration whereas itraconazole has limited entry in the brain. Therefore fluconazole is preferred over itraconazole for the treatment of cryptococcal meningitis. For all other conditions listed in the question, itraconazole is first choice drug.