This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematopoeisis: Basic concepts, Subject name: Pathology
Most immunogenic RBC blood group system out of the given options is:- 
Select and explain. 
A. Kell, B. Duffy, C. Kidd, D. Lewis antigen
A: Kell
Answer: A: Kell 
Explanation: Most immunogenic RBC blood group system:- ABO Blood Grouping > Rh> Kell. If there is mismatch b/w two individual on differential expression of the Kell ag, this can be responsible for Hemolytic diseases of new born (HDN) Duffy Receptor/Ag on RBC which facilitate the entry of plasmodium vivax. Therefore, those individual with Duffy negative RBC are resistant to plasmodium vivax Malaria.