This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation & Repair, Subject name: Pathology
The following is not a pyrogenic cytokine 
Select and explain. 
A. IL-1, B. TNF, C. Substance P, D. Prostaglandins
C: Substance P
Answer: C: Substance P 
Explanation: Ans. (c) Substance P(Ref: J Infect Dis. (1999) 179 (Supplement 2): S294-S304. doi: 10.1086/513856, Harrison 18th ed:2666.)IL1 AND TNF are well known pyrogenic cytokines In the hypothalamus, the prostaglandins, especially PGE2, stimulate the production of neurotransmitters that reset the temperature set point at a higher level, hence pyrogenic