This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Most impoant prognostic factor of wilms tumour - 
Select and explain. 
A. Histopathology, B. Ploidy of cells, C. Age < 1 yr, D. Mutation, of clp gene
A: Histopathology
Answer: A: Histopathology 
Explanation: Ans. is 'a' i.e., Histopathology o Anaplastic nuclear change is the only criterion of "unourable" histology in Wilm's tumor and all Wilm's tumor lacking this feature are designated as having "ourable histology". o Anaplastic nuclear change reflects extreme polypoidy & is usually apparent under low magnification. "Anaplastic histology remains a critical determinant of adverse prognosis. Even anaplasia restricted to kidney confers an increased risk of recurrence & death, underscoring the need for correctly identifying this histologic features."