This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Lymphohistiocytic variant of Reed Sternberg cells are typically seen in which of the following variants of Hodgkin&;s Lymphoma: 
Select and explain. 
A. Nodular Sclerosis, B. Lymphocyte Rich, C. Lymphocyte Predominant, D. Lymphocyte Depleted
D: Lymphocyte Depleted
Answer: D: Lymphocyte Depleted 
Explanation: Lymphocytic and histiocytic (L and H) variant of Hodgkin&;s Lymphoma is typical of Lymphocytic Predominant Hodgkin&;s Lymphoma. (True diagnostic Reed-Sternberg cells are not seen). The neoplastic cells resemble &;popcorn&; by viue of their folded or lobated nuclear nuclear membranes (nuclei resemble an exploded kernel of corn). Note that cells resembling the Lymphohistiocytic or popcorn cell variants of Lymphocyte Predominant (Non-classical) Hodgkin&;s Lymphoma may also be seen in Lymphocyte Rich Variant of Classical Hodgkin&;s Lymphoma. These if present can be differentiated by Immunophenotyping: Lymphocytic and Histiocytic (L & H) or &;popcorn&; cells are typical of Lymphocytic Predominant Non-Classical Hodgkin&;s Lymphoma. These cells are negative for CD15 and CD30 and positive for CD45. Cells resembling Lymphocytic and Histiocytic (L & H) or &;popcorn&; may be seen in Lymphocyte Rich form of classical Hodgkin&;s Lymphoma. These cells are positive for CD15 and CD30 and Negative for CD45. Ref: Bailey and Love 27th edition