This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical & Surgical Illness Complication Pregnancy, Subject name: Gynaecology & Obstetrics
Most sensitive screening test in diabetic mothers for congenital malformation is: 
Select and explain. 
A. MS AFP, B. Blood glucose, C. Amniotic fluid AFP, D. HbA1C (Glycosylated hemoglobin)
D: HbA1C (Glycosylated hemoglobin)
Answer: D: HbA1C (Glycosylated hemoglobin) 
Explanation: Ans. is d, i.e. Hb A1C (Glycosylated hemoglobin)Ref. Dutta Obs. 7/e, p 284Best screening test for congenital malformations: Hb A1c Best test to detect congenital malformations: TVS