This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Social & Preventive Medicine
Which of the following drugs used to treat MDR TB can cause hypothyroidism: 
Select and explain. 
A. Kanamycin, B. Pyrazinamide, C. Ethionamide, D. None of the above
C: Ethionamide
Answer: C: Ethionamide 
Explanation: Adverse effects of Ethionamide Gastro-intestinal: epigastric discomfo, anorexia, nausea, metallic taste, vomiting, excessive salivation, and sulfurous belching Psychiatric: hallucination and depression Hepatitis Hypothyroidism and goitre with prolonged administration Gynaecomastia, menstrual disturbances, impotence, acne, headache, and peripheral neuropathy Ref: