This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which antibodies in mother with SLE is responsible for congenital heart disease in child- 
Select and explain. 
A. Anti-histone, B. Anti-Ro & Anti-LA, C. Anti ds DNA, D. Anti-centromere
B: Anti-Ro & Anti-LA
Answer: B: Anti-Ro & Anti-LA 
Explanation: Most sensitive → Antinuclear antibody (ANA)
Most specific → Anti-double stranded antibody and the antibody against Smith (Sm)
Associated with neonatal lupus and congenital heart block → Anti Ro, Anti LA antibody
Associated with lupus psychosis → Anti P antibody