This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nutrition & Digestion, Subject name: Biochemistry
Pantothenate Kinase associated neurodegeneration is: 
Select and explain. 
A. Wiison's disease, B. Hallervorden-Spatz syndrome, C. McLeod syndrome, D. Lesch Nyhan syndrome
B: Hallervorden-Spatz syndrome
Answer: B: Hallervorden-Spatz syndrome 
Explanation: Ans. B. Hallervorden-Spatz syndromePantothenate kinase associated neuro degeneration (PKAN) (formerly Hallervorden-Spatz syndrome)Rare autosomal recessive neuro degenerative disorderChorea, dystonia, parkinsonian features, pyramidal tract features and MRMRI-decreased T2 signal in the globus pallidus and substantianigra, "eye of the tiger" sign (hyperintense area within the hypointense area)Sometimes acanthocytosisNeuropathologic examination indicates excessive accumulation of iron-containing pigments in the globuspallidus and substantianigra.Similar disorders are grouped as neurodegeneration with brain iron accumulation (NBIA).