This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
In contact dermatitis which cells play major role- 
Select and explain. 
A. T-cells, B. B-cells, C. Langhan cells, D. Macrophage
A: T-cells
Answer: A: T-cells 
Explanation: Contact dermatitis is a type IV hypersensitivity reaction. - this is a cell mediated response. The antigen activates specifically sensitised CD4 & CD8 T lymphocytes leading to the secretion of lymphokines and phagocyte accumulation. Reference : Anathanarayan & paniker's 9th edition, pg no: 162 <\p>