This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
A  20-year-old  patient  weighing  60  kg  has  to  be  prescribed  an  antiepileptic  drug  (available
as 200 and 400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters
and  therapeutic  plasma  concentration  of  the  selected  drug  are:
Target  steady-state  plasma  concentration  (Cpss) –  6  mg/L
Oral  bioavailability  (F) –  70%
Volume  of  distribution  (V) –  1.4  L/kg
Clearance  (CL) –  80  ml/hr/kg
Plasma  half  life  (t½) –  15  hours
What should be the loading dose and the daily maintenance dose of the drug for this patient? 
Select and explain. 
A. 720 and 984 mg respectively, B. 984 and 720 mg respectively, C. 450 and 720 mg respectively, D. 884 and 984 mg respectively
A: 720 and 984 mg respectively
Answer: A: 720 and 984 mg respectively 
Explanation: The total volume of distribution and total body clearance for this patients has to be calculated first.