This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hematology, Subject name: Pathology
VWF factor deficiency causes: 
Select and explain. 
A. | Platelet adhesion, B. | Factor VIII in plasma, C. Defective platelet adhesion, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: Deficiency of Von willebrand factor (VWF -promote platelet adherence and activation) causes | Platelet adhesion ( |BT ) | Intrinsic pathway activity ( | aPTT) | Factor VIII in plasma C/F Mucosal bleeding - Petechiae /purpura /epistaxis / melena Tissue bleeding Rx - Desmopressin for mild form - Cryoprecipitate for severe form