This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following anticancer drugs can cause a hypercoagulable state 
Select and explain. 
A. 5–FU, B. L–asparginase, C. Melphalan, D. Carmustine
B: L–asparginase
Answer: B: L–asparginase 
Explanation: L-asparginase causes the breakdown of aspargine and thus interferes with protein synthesis. It can inhibit the pro­duction of clotting factors (responsible for cerebral hemorrhage) as well as anti-clotting proteins (can lead to cortical vein thrombosis and other hypercoagulable states).