This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following cephalosporins does not need dose modifications even in presence of raised levels of GFR? 
Select and explain. 
A. Cefipime, B. Cefoperazone, C. Cefotaxim, D. Cefuroxime
B: Cefoperazone
Answer: B: Cefoperazone 
Explanation: Cefoperazone does not require dose adjustment when used in a patient with reduced GFR, as this drug is primarily excreted through the bile. Ref: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th Edition, Page 1210; Essentials of Medical Pharmacology By K D Tripathi, 5th Edition, Pages 664-6; KDT 6th Edition, Page 706