This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Next to metastasis, which is the most reliable feature to differentiate a benign from malignant tumour? 
Select and explain. 
A. Anaplasia, B. Dysplasia, C. Local invasion, D. Metastasis
C: Local invasion
Answer: C: Local invasion 
Explanation: .