This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Virology, Subject name: Microbiology
In acute hepatitis B, all are raised except 
Select and explain. 
A. HBsAg, B. IgM anti-HbC, C. Anti HBsAb, D. Total anti-HbC
B: IgM anti-HbC
Answer: B: IgM anti-HbC 
Explanation: Anti-HBc total antibodies (all classes of antibodies, ie IgG IgM) also increaseThe serological pattern of Hepatitis B virus:HBe Antigen positive chronic hepatitisHBe Antigen negative chronic hepatitis Replicative phase Non replicative phase HBV DNA ++HBeAg ++Intrahepatocyte HBcAg ++DNA polymerase ++HBV DNA very low HBeAg very low Intrahepatocyte HBcAg --Anti HBe ++HBV DNA ++HBeAg --DNA polymerase ++Hepatitis B patternSerological markersAcute Hepatitis BIg M Anti HBcAg ++ ; HBsAg ++Chronic Hepatitis B Ig G Anti HBcAg ++ ; HBsAg ++Marker of vaccination Anti HBsAg ++Marker of remote infection Ig G Anti HBcMarker of infectivity HBeAg Ref: Ananthanarayan 9th edition, p546-548