This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET Jan 2020, Subject name: Surgery
A 30 years old female presents with a diffuse thyroid swelling. On investigation, TSH levels were elevated. Post-operative HPE repos showed intense lymphocytic infiltration and Huhle cells. Which of the following is the most likely diagnosis? 
Select and explain. 
A. Grave's disease, B. Hashimoto's thyroiditis, C. Follicular carcinoma, D. Medullary thyroid carcinoma
B: Hashimoto's thyroiditis
Answer: B: Hashimoto's thyroiditis 
Explanation: HASHIMOTO'S THYROIDITIS- AkaStruma Lymphomatosa(conversion of thyroid tissue into lymphoid tissue) - Auto immune disorder -Anti- TPO (anti thyroid peroxidase) autoantibody - Associated with HLA B- 8, DR-3, D Clinical features - Signs & symptoms of Hypothyroidism Permanent destruction of follicles-> permanent hypothyroidism - Diagnosis is done by detection of anti TPO antibodies - FNAC Increased lymphocytic infiltration Presence ofHuhle cells/ Askanazy cells. Treatment Lifelong levothyroxine If Suspicion of malignancy - Total thyroidectomy