This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
A couple with Rh + female and Rh-male went for counseling of pregnancy. What should be advised - 
Select and explain. 
A. No treatment is needed, B. Vaccine to mother on first baby, C. Vaccine to first baby, D. Vaccine to father
A: No treatment is needed
Answer: A: No treatment is needed 
Explanation: Ans. is 'a' i.e.. No treatment is needed o Hemolytic disease of newborn is seen in couples when the female is Rh (-ve) and male is Rh (+ve); since the female has capacity to develop antibodies against the D antigen if fetomaternal hemorrhage takes place incase when the fetus is Rh(+ve). o But if mother is Rh+ then her immune system is already tolerant to D antigen and thus even if fetomaternal hemorrhage occurs and the fetus is Rh + no antibodies are developed and there is no risk for the fetus of subsequent pregnancies to develop hemolytic disease of newborn. So no treatment is required by the couple in question.