This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
Cataract in diabetic patients is because of the accumulation of sorbitol in the lens. The enzyme responsible for this is – 
Select and explain. 
A. Hexokinase, B. NADPH+ dependant aldolase reductase, C. Glucokinase, D. Phosphofructo isomerase
B: NADPH+ dependant aldolase reductase
Answer: B: NADPH+ dependant aldolase reductase 
Explanation: NADPH+ dependent aldolase reductase reduces excessive glucose to sorbitol and intracellular accumulation of sorbitol causes osmotic changes resulting in cataract development.