This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
Itch sensation from skin is carried by 
Select and explain. 
A. A alpha, B. A gamma, C. C-nerve fibre, D. Central itch centre
C: C-nerve fibre
Answer: C: C-nerve fibre 
Explanation: (C) C-nerve fibre # Itch Pathway: from Skin - C- Nerve Fibers - Dorsal Horn - Spinal Cord - Thlamus - Insula# Itch or Pruritus, is the major symptom in skin diseases with a variety of etiologies and pathophysiologies.> Significant progress has been achieved in understanding the pathophysiology of itch in the last 5 years.> Neurophysiological experiments in humans and animals have revealed that itch is carried by specific C nerve fibers.> Peripheral mediators other than histamine are involved in induction of itch.> Mast cell tryptase seems to be an important mediator in itch by its activation of proteinase activated receptor 2 in the sensory nerves.