This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
'Weak giants' are produced by - 
Select and explain. 
A. Thyroid adenomas, B. Thyroid carcinomas, C. Parathyroid adenomas, D. Pituitary adenomas
D: Pituitary adenomas
Answer: D: Pituitary adenomas 
Explanation: Ans. is 'd' i.e., Pituitary adenoma o In children and adolescent growth hormone hypersecretion prior to epiphyseal long bone closure causes gigantism. o The muscles often appear enlarged hut they have decreased force generation. o So, hyperpituitarism causes giants which have weak muscles and the most common cause of hyperpituitarism is pituitary adenoma. o Myopathy of hyperpituitarism - o Patients with hyperpituitarism have mild proximal weakness with muscle atrophy. Myopathy is related to the degreed of acromegaly. o Remember that all endocrinal disorders cause myopathy but none of them cause gigantism except hyperpituitarism.