This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Surgery
A 45 years old female presented to the OPD with breast lump of 4 cm in left breast. On examination left axillary lymph nodes were fixed and matted. Which of the following is the preferred treatment option? 
Select and explain. 
A. Breast conservation surgery + Axillary LN sampling + Radiotherapy, B. Simple mastectomy + Axillary LN sampling, C. Neoadjuvant chemotherapy + Modified radical mastectomy + Radiotherapy, D. Halsted radical mastectomy followed by Radiotherapy
C: Neoadjuvant chemotherapy + Modified radical mastectomy + Radiotherapy
Answer: C: Neoadjuvant chemotherapy + Modified radical mastectomy + Radiotherapy 
Explanation: EARLY INVASIVE BREAST Ca: stage I, IIA, IIB Rx: Breast conservation surgery (BCS) Axillary LN sampling (ALNS) Radio therapy If BCS contraindicated: simple mastectomy + ALNS LOCALLY ADVANCED BREAST Ca: stage IIIA, IIIB, IIIC Rx: Neoadjuvant chemotherapy Modified radical mastectomy Radio therapy Metastatic breast Ca Rx : Hormone therapy preferred over chemotherapy