This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Pathology
"Macropolycyte" in peripheral smear is a feature of 
Select and explain. 
A. Hereditary spherocytosis, B. Iron deficiency anaemia, C. Sickle cell anaemia, D. Megaloblastic anaemia
D: Megaloblastic anaemia
Answer: D: Megaloblastic anaemia 
Explanation: (D) Megaloblastic anaemia # Certain morphologic features are common to all forms of MEGALOBLASTIC ANEMIA.> The peripheral blood reveals marked variation in the size & shape of red cells (Anisocytosis), which are nonetheless normochromic.> Many erythrocytes are macrocytic & oval (macroovalocytes), with mean corpuscular volumes above 100 mm3 (normal, 82 to 92).> Neutrophils too are larger than normal (macro polymorphonuclear) & are hypersegmented, that is, have five to six or more nuclear lobules.