This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diagnosis in obstetrics, Subject name: Gynaecology & Obstetrics
An HIV positive, 36 years old female on A councils. Which of the following 1st trimester markers of Down Syndrome would be affected by? 
Select and explain. 
A. B-hcg, B. PAPP-A, C. NT, D. All of the above
A: B-hcg
Answer: A: B-hcg 
Explanation: Triple test It is a combined biochemical test which includes MSAFP,hCG,UE3 Used in detection of down&;s syndrome In an affected pregnancy level of MSAFP AND UE3 tend to be low and hCG is high performed at 15-18weeks D.C.DUTTA&;S TEXTBOOK OF OBSTETRICS,Pg no:106,7th edition