This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S., Subject name: Pediatrics
Children born to mothers with systemic lupus erythematosus are likely to have one of the following anomalies: 
Select and explain. 
A. Atrial septal defect, B. Tetralogy of Fallot, C. Transposition of great vessels, D. Complete heart block
D: Complete heart block
Answer: D: Complete heart block 
Explanation: d. Complete heart block(Ref: Nelson's 20/e p 2171-2174, Ghai 8/e p 457-461)Congenital complete AV blockIt is presumed to be caused by autoimmune injury of fetal conduction system by maternally derived anti-SSA/Ro, anti-SSB/ La antibodies in a mother with systemic lupus erythematosus (SLE) or Sjogren syndromeAutoimmune disease accounts for 60-70% of all cases of congenital complete heart block