This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplasia, Subject name: Pathology
Which is not a feature of neoplastic cell? 
Select and explain. 
A. Hyperchromasia, B. Pleomorphism, C. Atypical mitoses, D. Nuclear cytoplasmic ratio 1:4
D: Nuclear cytoplasmic ratio 1:4
Answer: D: Nuclear cytoplasmic ratio 1:4 
Explanation: Ans: d (Nuclear cytoplasmic ratio 1:4)The hallmark of malignant transformation is anaplasia.The morphological changes in anaplasia are:-1) Pleomorphism: by both cell & nuclei2) Abnormal nuclear morphology: HyperchromasiaNuclear cytoplasmic ratio approaches 1:1 (normal is 1:4 or 1:6)Large nucleoli3) Large no of mitoses4) Loss of polarity5) Other changes: tumour giant cells