This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
Which of the following drugs require dose adjustment in renal failure 
Select and explain. 
A. Cefoperazone, B. Doxycycline, C. Streptomycin, D. Rifamipicin
C: Streptomycin
Answer: C: Streptomycin 
Explanation: Ref Katzung 10/r p 835 Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas Doxycycline, Rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure