This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: dermatology and infectious disease, Subject name: Pathology
Breslow thickness is used in 
Select and explain. 
A. Melanoma, B. Squamous cell carcinoma, C. Basal cell carcinoma, D. Actinic keratosis
A: Melanoma
Answer: A: Melanoma 
Explanation: In melanoma, the probability of metastasis correlates with the depth of invasion, which by convention is the distance from the superficial epidermal granular cell layer to the deepest intradermal tumour cells; this measurement is known as the Breslow thickness.The probability of metastatic spread and prognosis, to predict an outcome is based on the following variables:(1) tumour depth (the Breslow thickness); (2) number of mitoses; (3) evidence of tumour regression (presumably due to the host immune response); (4) ulceration of overlying skin; (5) the presence and number of tumour infiltrating lymphocytes; (6) gender; and (7) location (central body or extremity)Since most melanomas initially metastasize to regional lymph nodes, additional prognostic information may be obtained by performing a sentinel lymph node biopsyRobbins Pathology 9e pg: 1150