This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pathology of Conception, Subject name: Gynaecology & Obstetrics
Which is not increased in PCOS - 
Select and explain. 
A. Estrogen, B. Luetinizing hormone, C. Sex hormone binding globulin, D. Insulin
C: Sex hormone binding globulin
Answer: C: Sex hormone binding globulin 
Explanation: Ans. is 'c' i.e., Sex hormone binding globulin o Endocrinologic changes in PCOS are as follows :# Oestrone / E2 level rises# LH level is raised over 1 OlU/ml# FSH level remains normal, but FSH/LH ratio falls.# SHBG level falls due to hyperandrogenism# Testosterone and epiandrstenedione levels rise.# Fasting insulin is more than 10mIU/l.# Thyroid function test may be abnormal (hypothyroidism).