This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hypo Pigmentary Disorders, Subject name: Dental
Which topical agent is antiproliferative, cytotoxic to melanocytes and a weak competitive inhibitor of tyrosinase? 
Select and explain. 
A. Kojic acid, B. Hydroquinone, C. Retinoids, D. Azelaic acid
D: Azelaic acid
Answer: D: Azelaic acid 
Explanation: Azelaic acid - Tyrosinase inhibitor Has anti-inflammatory propeies and antiproliferative effect on keratinocytes - used in acne Has cytotoxic action against Melanocytes - used in Hyperpigmentary disorders Tyrosinase inhibitors - used for hyperpigmented disorders like melasma Eg -1. Hydroquinone2. Azelaic acid 3. Kojic acid4. Arbutin