This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endometriosis & H, Subject name: Gynaecology & Obstetrics
Danazol used in the treatment of endometriosis causes which of the following changes within the endometrium and endometriosis tissue? 
Select and explain. 
A. Aplasia, B. Atrophy, C. Hyperplasia, D. Neoplasia
B: Atrophy
Answer: B: Atrophy 
Explanation: Danazol Isoxazole derivative of 17 - alpha ethinyl testosterone propeies Causes atrophy of endometrium It is strictly antigonadotropin but acts as an androgen agonist Mode of action Acting on the hypothalamo - pituitary - gonadal axis - depression of frequency of GnRh pulses - suppression of pituitary FSH and LH surge. There is however no change in the basal gonadotropin level Indication of danazol Endometriosis DUB Symptomatic fibroid Precocious pubey