This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
The shape of RBC is biconcave due to 
Select and explain. 
A. Ferrous state of Iron, B. Spectrin, C. Band protein, D. Glycophorin C
B: Spectrin
Answer: B: Spectrin 
Explanation: The remarkable deformability and durability of the normal red cell are attributable to the physicochemical propeies of its specialized membrane skeleton, which lies closely apposed to the internal surface of the plasma membrane. Its chief protein component is spectrin.Hereditary spherocytosis is caused by diverse mutations that lead to an insufficiency of membrane skeletal componentsRobbins 9e pg: 632