This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
Features, which are evaluated for histological grading of breast carcinoma, include all of the following except 
Select and explain. 
A. Tumour necrosis, B. Mitotic count, C. Tubule formation, D. Nuclear pleomorphism
A: Tumour necrosis
Answer: A: Tumour necrosis 
Explanation: Histological grading is based on nuclear pleomorphism; tubule formation, mitotic count Nuclear pleomorphism: Score 1--relatively small uniform nuclei; score 2--intermediate pleomorphic nucleoli; score 3--relatively large prominent nucleoli Mitotic count: Score 1-- < 10% mitoses in 10 HPF; score 2- 10-20% mitoses; score 3-- >20% mitoses Tubule formation: Score 1-->75% cells in tubule forms; score 2--10-75% cells in tubule forms; score 3--< 10% cells in tubule forms Grade Score Favourable 1 Unourable Up to 3 Grade I 3-5 Grade II 6-7 Grade III 8-9 Ref; (page no;534 ) 5th edition of SRB&;S manual of Surgery