This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
True statement about cyclooxygenase-2 is 
Select and explain. 
A. It Is not inhibited by indomethacin, B. It I'd inducible, C. It generate cytoprotective prostaglandins in gastric mucosa, D. It is found only in fatal tissues
B: It I'd inducible
Answer: B: It I'd inducible 
Explanation: Ref-KDT 6/e p185 COX-1 is a house-keeping enzvme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a non-selective inhibitor of both isoforms of COX.