This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2017, Subject name: Pathology
Schistocytes in peripheral smear are seen in all except: 
Select and explain. 
A. DIC, B. Sickle cell anemia, C. TTP, D. HUS
B: Sickle cell anemia
Answer: B: Sickle cell anemia 
Explanation: Schistocyte is fragmented RBC which is seen in any condition where there is micro and macro angiopathic hemolytic anemias. Microangiopathic hemolytic anemia is most commonly seen with DIC, TTP, hemolytic-uremic syndrome (HUS), malignant HTN, SLE, and disseminated cancer. Macroangiopathic schistocyte is seen in patient with prosthetic hea valve. Sickle cell anemia: Blockage of vessels by sickled cells causes pain crises and tissue infarction, paicularly of the marrow and spleen. Red cell membrane damage caused by repeated bouts of sickling results in a moderate to severe hemolytic anemia.