This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Aseptic loosening in cemented total hip replacement, occurs as a result of hypersensitivity response to: 
Select and explain. 
A. Titanium debris, B. High density polythene debris, C. N. N-Dimethyltryptamine (DMT), D. Free radicals
B: High density polythene debris
Answer: B: High density polythene debris 
Explanation: B i.e. High density polythene debris Paicles of metal (titanium, nickel, chromium etc), cement (PMMA) and polyethylene all can produce periprosthetic osteolysis (aseptic loosening) ; but because they are most numerous polyethylene paicles appear to be the major culpritQ.