This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
Furosemide should not be administered with NSAIDS because? 
Select and explain. 
A. Prevent platelet aggregation, B. Inhibit prostacyclin synthesis, C. Decrease sodium reabsorption, D. Increase the secretion of furosemide in urine
B: Inhibit prostacyclin synthesis
Answer: B: Inhibit prostacyclin synthesis 
Explanation: NSAIDs diminish the action of high ceiling diuretics by inhibiting the PG synthesis in the kidney, through which furosemide and related drugs act on the kidney. Antihypeensive action of thiazides and furosemide is also diminished by NSAIDs. REF -Essentials of medical pharmacology, K.D Tripathi, 6th edition, page 568