This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Irreversible cell injury is due to? 
Select and explain. 
A. Membrane damage, B. Bleb formation, C. Loss of microvilli, D. Detachment of ribosomes
A: Membrane damage
Answer: A: Membrane damage 
Explanation: Membrane damage is the central pathogenic process in irreversible injury
All other changes occur in reversible injury.