This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
All of the following are seen in Neurofibromtosis, Except 
Select and explain. 
A. Lisch nodules, B. Axillary Freckling, C. Shagreen Patch, D. Caffe-au-lait spots
C: Shagreen Patch
Answer: C: Shagreen Patch 
Explanation: Answer is C (Shgreen Patch): Shagreen Patch is seen in Tuberous Sclerosis and not in Neurofibromatosis Lisch Nodules, Axillary Freckling and Caffe-au-lait spots are seen in Neurofibromotosis Shagreen Patch are seen in Tuberous Sclerosis Shagreen Spotsdeg are roughened, raised, leathery lesions with an orange peel consistency seen as cutaneous manifestations of Tuberous sclerosis