This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Most potent stimulator of naive T cell is 
Select and explain. 
A. Mature dendritic cells, B. Follicular dendritic cells, C. Macrophage, D. Bcell
A: Mature dendritic cells
Answer: A: Mature dendritic cells 
Explanation: Ref Robbins 9/e p191 Naive T cells leave the thymus and home to secondary lymphoid organs. Dendritic cells are the most potent activators of naive T cells. DCs carry antigen from the periphery to the draining lymph nodes. ... CD28 signaling provides "Signal 2" to T cells and is necessary for T cell activation.