This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Chromophobe variant of Renal cell carcinoma is associated with: 
Select and explain. 
A. VHL gene mutations, B. Trisomy of 7 and 17 (+7, +17), C. 3 p deletions (3p-), D. Monosomy of 1 and Y (-1, -Y)
D: Monosomy of 1 and Y (-1, -Y)
Answer: D: Monosomy of 1 and Y (-1, -Y) 
Explanation: Cytogenetic examination of chromophobe RCC shows multiple and complex losses of chromosome Y, 1, 2, 6, 10, 13, 17, 21. Hypoploidy and various other chromosome losses (-1, -Y) are detectable in Chromophobe variant of Renal cell carcinoma. Ref: Harrison's Principles of Internal Medicine, 16th Edition, Page 541; Renal Cancer By Stadler, Walter, 2011, Page 263; Sternberg's Diagnostic Surgical Pathology Review By Pier Luigi DiPatre, Darryl Caer, Stephen S. Sternberg, Page 205