This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Febrile response in CNS is mediated by all except 
Select and explain. 
A. Bacterial toxin, B. IL-l, C. IL-6, D. Interferon
C: IL-6
Answer: C: IL-6 
Explanation: Fever is produced in response to substances called pyrogens that act by stimulating prostaglandin synthesis in the vascular and perivascular cells of hypothalamus.
They can be classified as:

Exogenous pyrogens - Endotoxin of gram ‘-’ bacteria, superantigens (gram ‘+’ bacteria).
Endogenous pyrogens - IL-1, TNF-alpha, Ciliary neurotropic factor and IFN-alpha.

PGE 2 is the most important chemical responsible for elevation of hypothalamic set point in the body.
So, NSAIDs reduce fever by inhibiting cyclooxygenase and reducing prostaglandin concentration.