This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Treatment of multiple carboxylase deficiency ? 
Select and explain. 
A. Biotin, B. Pyridoxine, C. Thiamine, D. Folic acid
A: Biotin
Answer: A: Biotin 
Explanation: Ans. is 'a' i.e., Biotin Pathogenesis of multiple carboxylase deficiency o Deficiency of either holocarboxylase synthase or biotinidase impaires biotin metabolism. o Biotin is a cofactor for various carboxylases in the body ? o Impaired metabolism of biotin results in multiple carboxylase deficiency. o So, for the treatment of multiple carboxylase deficiency, biotin should be given.