This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following group of antibiotics possess additional anti inflammatory and immunomodulatory activities ? 
Select and explain. 
A. Tacrolimus, B. Polypeptide antibiotics, C. Fluoroquinolones, D. Macrolides
A: Tacrolimus
Answer: A: Tacrolimus 
Explanation: Tacrolimus is a macrolide antibiotic, it acts by inhibiting cytokine production. It possess anti-inflammatory and immunomodulatory activities. Mechanism: Tacrolimus binds to FKBP 12 and forms a complex. This then binds to calcineurin and inhibits calcineurin phosphates activity. Because of this it cannot dephosphorylate NFATc, and prevents its migration into nucleus and activation of cytokines. Ref: Immunopharmacology By Manzoor M. Khan, Pages 91-3