This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
Which one of the following oral hypoglycemic agents is not an insulin secretogogue ? 
Select and explain. 
A. Gliclazide, B. Glimiperide, C. Repaglinide, D. Rosiglitazone
D: Rosiglitazone
Answer: D: Rosiglitazone 
Explanation: Rosiglitazone is a thiazolidinedione which reduce insulin resistance by binding to the PPAR-g (peroxisome proliferator-activated receptor g) nuclear receptor (which forms a heterodimer with the retinoid X receptor). The PPAR-g receptor is found at highest levels in adipocytes. Agonists of this receptor regulate a large number of genes, promote adipocyte differentiation, reduce hepatic fat accumulation, and promote fatty acid storage. Thiazolidinediones promote a redistribution of fat from central to peripheral locations. Thus it enhances the actions of endogenous insulin. Reference : page 2415 Harrison's Principles of Internal Medicine 19th edition