This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Surgery
Van Buchem&;s syndrome is characterized by all except: 
Select and explain. 
A. Overgrowth, B. Distoion of mandible, C. Facial palsy, D. Increased acid Phosphatase
B: Distoion of mandible
Answer: B: Distoion of mandible 
Explanation: Van Buchem Disease: Van Buchem disease (hyperostosis coicalis generalisata) is an autosomal recessive disorder characterized by hyperostosis of the skull, mandible, clavicles, ribs, and diaphyseal coices of the long bones Most striking clinical features are the enlargement of the jaw and thickness of the skull, which may lead to facial nerve palsy, hearing loss, and optic atrophy Ref: