This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Which of the following is the effect of restriction endonuclease on nucleotides? 
Select and explain. 
A. Break single stranded DNA, B. Break double stranded DNA, C. Break RNA, D. Break peptide chain
B: Break double stranded DNA
Answer: B: Break double stranded DNA 
Explanation: Restriction endonucleases breaks down the double stranded DNA in a specific manner.