This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Ovarian Hyperstimulation Syndrome (OHSS), Subject name: Gynaecology & Obstetrics
All are true about pathogenesis of Ovarian Hyperstimulation Syndrome, EXCEPT? 
Select and explain. 
A. Due to ovarian enlargement and fragility, B. Increase in intravascular volume, C. Role of VEGF and inflammatory cytokines, D. Secondary to infeility treatment
B: Increase in intravascular volume
Answer: B: Increase in intravascular volume 
Explanation: Symptoms of OHSS are the result of ovarian enlargement and fragility, extravascular fluid accumulation, and intravascular volume depletion (and not increase as stated in option b). Fluid shifts that accompany OHSS are due to increased protein-rich fluid secretion from the stimulated ovaries, increased renin and prorenin within follicular fluid, increased capillary permeability and VEGF