This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Glycogen, Subject name: Biochemistry
Which of the following condition causes hyperuricemia due to both increased production and decreased excretion? 
Select and explain. 
A. PRPP Synthetase over activity, B. Glucose-6-phosphatase Deficiency, C. HGP deficiency, D. Renal failure
B: Glucose-6-phosphatase Deficiency
Answer: B: Glucose-6-phosphatase Deficiency 
Explanation: Von Gierke disease cause hyperuricemia by both ways: Overproduction: Glucose 6 phosphatase deficiency leads to diversion of glucose-6-phosphate to HMP shunt -| ribose-5-phosphate -|PRPP - nucleotide synthesis - |Uric Acid. Underexcretion: Accumulated lactic acid competes with uric acid for renal excretion.