This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anaesthesia, Subject name: Anaesthesia
Which of the following inhalational agent is contraindicated in renal disease? 
Select and explain. 
A. Methoxyflurane, B. Sevoflurane, C. Desflurane, D. Isoflurane
A: Methoxyflurane
Answer: A: Methoxyflurane 
Explanation: Methoxyflurane produces inorganic fluoride, which was responsible for the sporadic incidence of nephrotoxicity (i.e., high-output renal failure) after prolonged anesthesia Basics of anesthesia 7e pg:95