This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neoplastic disorders of WBCs, Subject name: Pediatrics
In AML best prognosis is seen with 
Select and explain. 
A. Acute megakaryocytic leukemia, B. Acute monocytic leukemia, C. Acute promyelocytic lukemia (M3), D. Erythroleukemia
C: Acute promyelocytic lukemia (M3)
Answer: C: Acute promyelocytic lukemia (M3) 
Explanation: - Acute Promyelocytic Leukemia (APML): characterized by a gene rearrangement involving retinoic acid receptor It is very responsive to all-trans retinoic acid (ATRA, tretinoin) combined with anthracyclines and cytarabine. The success of this therapy makes Bone marrow transplantation unnecessary in 1st remission. Arsenic trioxide is also an effective non-cytotoxic therapy for APML