This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Basic Concepts and Vascular changes of Acute Inflammation, Subject name: Pathology
All of the following are cardinal signs of inflammation except: 
Select and explain. 
A. Pain, B. Swelling, C. Redness, D. Absence of functional loss
D: Absence of functional loss
Answer: D: Absence of functional loss 
Explanation: Celsus first listed the four cardinal signs of inflammation: rubor (redness), tumor (swelling), calor (heat), and dolor (pain). These signs are hallmarks of acute inflammation. A fifth clinical sign, loss of function (functio laesa), was added by Rudolf Virchow.