This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following statements is NOT TRUE about NSAIDs ? 
Select and explain. 
A. Acetyl salicylic acid is an irreversible inhibitor of COX enzyme., B. Acetylsalicylic acid reduces in vivo synthesis of prostaglandins., C. Its clearance is independent of plasma concentration, D. Antiplatelet effect of low dose aspirin is related to pre-systemic COX inhibition
C: Its clearance is independent of plasma concentration
Answer: C: Its clearance is independent of plasma concentration 
Explanation: None