This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2019, Subject name: Pathology
Most characteristic finding of diabetic nephropathy? 
Select and explain. 
A. Kimmelstein Wilson disease, B. Diffuse glomerulosclerosis, C. Focal segmental glomerulosclerosis, D. Armani Ebstein change
A: Kimmelstein Wilson disease
Answer: A: Kimmelstein Wilson disease 
Explanation: Diabetic Nephropathy Three lesions are encountered: (1) glomerular lesions; (2) renal vascular lesions, principally aeriolosclerosis; and (3) pyelonephritis, including necrotizing papillitis. The most impoant glomerular lesions are capillary basement membrane thickening, diffuse mesangial sclerosis, and Nodular glomerulosclerosis. Capillary Basement Membrane Thickening. Widespread thickening of the glomerular capillary basement membrane (GBM) occurs in viually all cases of diabetic nephropathy and is pa and parcel of the diabetic microangiopathy Diffuse Mesangial Sclerosis. This lesion consists of diffuse increase in mesangial matrix. Nodular Glomerulosclerosis. This is also known as intercapillary glomerulosclerosis or Kimmelstiel-Wilson disease. It is the Most characteristic finding of Diabetic Nephropathy.