This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The diuretic group that does not require access to the tubular lumen to induce diuresis is ? 
Select and explain. 
A. Carbonic anhydrase inhibitor, B. Na-Cl sympo inhibitor, C. Mineralocoicoid antagonist, D. Na-K sympo inhibitor
C: Mineralocoicoid antagonist
Answer: C: Mineralocoicoid antagonist 
Explanation: Ans. is 'c' i.e. Mineralocoicoid antagonist Spirinolactone is mineralocoicoid (aldosterone) antagonist. It opposes the action of Aldosterone without requiring access to the tubular lumen. Spirinolactone (as well as aldosterone) act from the interstitial side.