This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Abortion, Subject name: Gynaecology & Obstetrics
A woman with H/o recurrent abortions presents with isolated increase in APTT. Most likely cause is: 
Select and explain. 
A. Lupus anticoagulant, B. Factor VII, C. Von Willebrand's disease, D. Hemophilia A
A: Lupus anticoagulant
Answer: A: Lupus anticoagulant 
Explanation: Ans. is a, i.e. Lupus anticoagulantRef. Dutta Obs. 6/e, p 343; Fernando Arias 3/e, p 327; Leon Speroff 7/e, p 1082Isolated increase in APTT is suggestive of lupus anticoagulant.