This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Anticentromere antibodies are most commonly associated with: 
Select and explain. 
A. Diffuse cutaneous systemic sclerosis, B. Mixed connective tissue disease, C. CREST syndrome, D. Polymyositis
C: CREST syndrome
Answer: C: CREST syndrome 
Explanation: Anti-centromere antibodies react with protein antigens located in the kinetochore region of chromosomes and are present in 40 to 80% of patients with limited cutaneous scleroderma or CREST syndrome. So CREST syndrome is the single best answer of choice. Ref: Harrisons Principles of Internal Medicine, 16th Edition, Pages 1979, 1986.