This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Regional anaesthesia, Subject name: Anaesthesia
Local Anesthetic first used 
Select and explain. 
A. Procaine, B. Lignocaine, C. Bupivacaine, D. Cocaine
D: Cocaine
Answer: D: Cocaine 
Explanation: Cocaine was the earliest used local anaesthesia(1st time used by Carl Koller in 1884 for occular surgery) cocaine is a naturaly occuring ester linked local anesthetic