This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Psoriasis, Subject name: Dental
The first biologic agent approved by US FDA for the treatment of psoriasis is: 
Select and explain. 
A. Alefacept, B. Efalizumab, C. Etanercept, D. Infliximab
A: Alefacept
Answer: A: Alefacept 
Explanation: In 2003, Alefacept became the first biological agent to be licensed for the treatment of severe psoriasis. Alefacept is a T-cell inhibitor - binds to CD-2 Infliximab, Etanercept- are TNF-a inhibitor Efalizumab is a T-cell inhibitor binds to CD-11