This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Loop diuretics such as furosemide act by : 
Select and explain. 
A. Decreasing tubular reabsorption of Na+ and increase GFR, B. Decreasing FP secretion with resultant increase in Na+ and K+excretion, C. Inhibiting Na+ + K+ – 2Cl– co transporter in the medullary thick ascending limb, D. Inhibiting Na+ – K+exchange in the collecting duct
C: Inhibiting Na+ + K+ – 2Cl– co transporter in the medullary thick ascending limb
Answer: C: Inhibiting Na+ + K+ – 2Cl– co transporter in the medullary thick ascending limb 
Explanation: None