This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S., Subject name: Medicine
Inclusions in oligodendrogliocytes is a feature of: 
Select and explain. 
A. Polio, B. Multiple sclerosis, C. HSV, D. Progressive multiple encephalopathy
D: Progressive multiple encephalopathy
Answer: D: Progressive multiple encephalopathy 
Explanation: Ans. D. Progressive multiple encephalopathyProgressive Multifocal Leukoencephalopathya. PML is a rare demyelinating CNS disorder caused by the reactivation of JC virus.b. The virus stays latent in the kidneys and lymphoid organs until reactivation.c. PML mainly occurs in adults with impaired cell-mediated immunity, especially AIDS patients but also in those with lymphoproliferative and myeloproliferative disorders. Decreasing immunosuppression in non-AIDS patients with PML (e.g. Transplant patients).d. JCV causes lytic infection of oligodendrocytes in the white matter.e. Symptoms include altered mental status, aphasia, ataxia, hemiparesis or hemiplegia and visual filed disturbances, Seizures.f. Treatment: Risperidone and mirtazapine.Oligodendrocyte inclusion bodies are seen in PML