This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bacterial infections, Subject name: Dental
The main cytokine, involved in erythema nodosum leprosum (ENL) reaction is- 
Select and explain. 
A. lnterleukin - 2, B. Interferon - gamma, C. Tumor necrosis factor - alpha, D. Macrophage colony stimulating factor
C: Tumor necrosis factor - alpha
Answer: C: Tumor necrosis factor - alpha 
Explanation: The main cytokines responsible for type 2 leprosy reactions are interleukin 1 and tumour necrosis factor alpha. iadvl textbook of dermatology, page 2049