This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Which of the following antibodies is most frequently seen in Antiphospholipid Syndrome ? - 
Select and explain. 
A. Beta 2 microglobulin antibody, B. Anti-nuclear antibody, C. Anti-centromere antibody, D. Anti- beta 2 glycoprotein antibody
D: Anti- beta 2 glycoprotein antibody
Answer: D: Anti- beta 2 glycoprotein antibody 
Explanation: Antiphospholipid antibody syndrome has clinical manifestations including recurrent thrombosis, repeated miscarriages, cardiac valve vegetations and thrombocytopenia. Suspected Ab target include Beta 2 Glycoprotein 1, a plasma protein that associates with the surfaces of endothelial cells and trophoblasts. Anti nuclear antibody and beta 2microglobulin Ab seen in SLE. Reference : Robbins and Cotran Pathologic basis of disease.South Asia Edition -9;volume 1.page no. 124