This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Takotsubo Cardiomyopathy and Brugada Syndrome, Subject name: Medicine
Which disorder of carbohydrate metabolism disorder typically has cardiac involvement? 
Select and explain. 
A. Glycogen Storage Disease Type II (Pompe), B. Galactosemia, C. Glycogen Storage Disease Type I (Von-Gierke), D. Hereditary fructose intolerance
A: Glycogen Storage Disease Type II (Pompe)
Answer: A: Glycogen Storage Disease Type II (Pompe) 
Explanation: Classic infantile form of Pompe disease presents with Cardiomyopathy and conduction disorders Muscular hypotonia / floppy baby Macroglossia Organomegaly Cardiomyopathy- hyperophic type, severe thickening of the septum and free walls of the left and right hea. Glycogen storage involves cardiac myocytes, special cells of the conduction system (A-V node and His-bundle cells), representing the histological background of classical ECG abnormalities in Pompe disease: pre-excitation patterns (sho PR, delta waves), AV blocks and bundle branch abnormalities.