This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Ophthalmology
Retinoblastoma – 
Select and explain. 
A. Is inherited in 50% of cases, B. Is caused by deletion of 11q14, C. Rosettes suggest good prognosis, D. Causes death in 60% of sufferers in the UK
C: Rosettes suggest good prognosis
Answer: C: Rosettes suggest good prognosis 
Explanation: Rosettes are feature of well differentiated retinoblastoma, therefore suggest the good prognosis.
Hereditary retinoblastoma accounts for 40% of cases and the gene is located at 13q14 chromosome.
Prognosis is fair with 70-85% survival rate if the eyeball is enucleated before the occurrence of extra ocular extension.