This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Cephalosporin that does not require dose reduction in a patient with any degree of renal impairment is : 
Select and explain. 
A. Cefuroxime, B. Cefoperazone, C. Ceftazidime, D. Cefotaxime
B: Cefoperazone
Answer: B: Cefoperazone 
Explanation: Ceftriaxone and cefoperazone are excreted mainly in the bile, therefore do not require dose reduction in any grade of renal failure.