This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pathology
Toxic megacolon is most commonly associated with 
Select and explain. 
A. Ulcerative colitis, B. Crohn's disease, C. Whipple's disease, D. Reiter's disease
A: Ulcerative colitis
Answer: A: Ulcerative colitis 
Explanation: inflammation and inflammatory mediators can damage the muscularis propria and disturb neuromuscular function leading to colonic dilation and toxic megacolon TEXT BOOK OF ROBBINS BASIC PATHOLOGY NINTH EDITION PAGE.590-591