This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Drugs causing pharmacological adrenalectomy are all except 
Select and explain. 
A. Ketoconozole, B. Mitotane, C. Aminoglutethemide, D. Methotrexate
D: Methotrexate
Answer: D: Methotrexate 
Explanation: Aminoglutethimide, Ketoconazole, Mitotane, Trilostane, Metyrapone inhibits synthesis of steroids Pharmacological adrenelectomy refers to mimicking a situation of adrenelectomy where the complete synthesis of coicosteroids is stopped by using drugs line glucocoicoid synthesis inhibitors. Ref: Katzung 11th ed pg 695.