This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (E.N.T.), Subject name: ENT
Gvnaecomastia may be associated with 
Select and explain. 
A. Klinefelter's syndrome, B. Feminizing tumour of adrenal gland, C. Normal adolescent boys who are rapidly virilizing, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: (D) All of the above # Pathological gynecomastia may result from deficiency of testosterone (anorchia, Klinefleter's, androgen resistance orchitis & castration); Increased production of estrogens (testicular or adrenal tumours, hCG secreting tumours> Drugs (ketoconazole, spironolactone & Cemitidine inhibit testosterone); clomiphene enhances endogenous estrogen