This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Pleomorphic adenoma histology is characterized by? 
Select and explain. 
A. Epithelial component, B. Endothelial component, C. Mesodermal component, D. Mixed epithelial and mesenchymal components
D: Mixed epithelial and mesenchymal components
Answer: D: Mixed epithelial and mesenchymal components 
Explanation: Ans. is 'd' i.e., Mixed epithelial and mesenchymal components They are derived from a mixture of ductal (epithelial ) and myoepithelial cells and therefore they show both epithelial and mesenchymal differentiation -Also called mixed tumor. Pleomorphic adenoma :? This is the Commonest neoplasm of Salivary glands. The most Common salivary gland involved is Parotid - represent about 60% tumors in the parotid. Submandibular and minor salivary glands may also be involved rarely. Pleomorphic adenoma - Parotid > Submandibular > minor salivary glands. They are derived from a mixture of ductal (epithelial ) and myoepithelial cells and therefore they show both epithelial and mesenchymal differentiation - Also called mixed tumor.