This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T., Subject name: Physiology
Appetite is increased by 
Select and explain. 
A. Leptin, B. GLP, C. Peptide YY, D. Ghrelin
D: Ghrelin
Answer: D: Ghrelin 
Explanation: Ans. (d) Ghrelin(Ref: Ganong, 25th ed/p.485)Ghrelin#Ghrelin is a 28-amino acid peptide secreted primarily by oxyntic gland area of the stomach#Major Functions of ghrelin are,It increases the appetite (orexinergic)Increases gastric motilityIncreases secretion of gastric acid,Increases adipogenesisIncreases insulin secretionIncreases growth hormone#Ghrelin levels peak just before food intake begins (fasting state)#Plasma levels of ghrelin are low in obese persons#Ghrelin levels are high in anorexia nervosa