This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inborn Errors of Metabolism, Subject name: Pediatrics
Wrinkled paper appearance of macrophage in bone marrow aspirate is seen in: 
Select and explain. 
A. Niemann Pick disease, B. Gaucher disease, C. Hemophagocytic lymphohistiocytosis, D. Langerhan cell histiocytosis
B: Gaucher disease
Answer: B: Gaucher disease 
Explanation: b. Gaucher disease(Ref: Nelson's 20/e p 708-712, Ghai 8/e p 659-664)Gaucher cells are Lipid Laden Macrophages have a characteristic histologic appearance of "wrinkled tissue paper"Membrane-bound inclusions filled with glucocerebroside are seen with electron microscopy.