This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Apparent volume of distribution of a drug exceeds total body fluid volume, if a drug is 
Select and explain. 
A. Sequestrated in body tissues, B. Slowly eliminated from body, C. Poorly soluble in plasma, D. High bound to plasma proteins
A: Sequestrated in body tissues
Answer: A: Sequestrated in body tissues 
Explanation: Lipid insoluble drugs do not enter cell. Ref-KDT 6/e p18