This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S., Subject name: Pediatrics
Which one is the best prognostic factor for ALL? 
Select and explain. 
A. Hyperploidy, B. Orgnomegaly, C. TLC more than 50,000/mL, D. Response to treatment
D: Response to treatment
Answer: D: Response to treatment 
Explanation: d. Response to treatment(Ref: Nelson's 20/e p 2437, Ghai 8/e p 599)Discussing options one by one:a. HyperploidyIntermediate prognosis; can be considered goodb. OrganomegalyL. Node, liver, spleen enlargement, Testicular enlargement - poor prognosisc. TLC >50,000/mLPoor prognosis; TLC <10,000/mL has good prognosisd. Response to treatmentEarly response to treatment is a good prognostic factor for ALL