This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Which of the following opioids should not be used with MAO inhibitors? 
Select and explain. 
A. Morphine, B. Pentazocine, C. Buprenorphine, D. Pethidine
D: Pethidine
Answer: D: Pethidine 
Explanation: pethidine Nonselective MAO inhibitors interfere with hydrolysis but not with demethylation of pethidine - norepithidine is produced in excess and excitement occurs. Excitatory effects include trmors, mydriasis, hyperreflexia, delirium, myoclonus, convulsions etc. Ref: KD Tripathi 8th ed.