This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pathology
GNAS mutation is associated with malignancy of 
Select and explain. 
A. Lactotrophs, B. Somatotrophs, C. Thyrotrophs, D. Coicotrophs
B: Somatotrophs
Answer: B: Somatotrophs 
Explanation: GNAS encodes for alpha subunit of stimulatory G-protein , Gsalpha . Oncogenic activation of GNAS constitutively activates Gsalpha leading to Growth hormone(GH) adenomas. Ref: Robbins and cotrans 9e Pg 1076