This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Viral Drugs, Subject name: Pharmacology
Mechanism of action of Oseltamivir and Zanamivir is:- 
Select and explain. 
A. DNA polymerase inhibition, B. Inhibition of viral mRNA, C. Blocking viral uncoating, D. Neuraminidase inhibition
D: Neuraminidase inhibition
Answer: D: Neuraminidase inhibition 
Explanation: Oseltamivir acts by inhibiting influenza virus neuraminidase enzyme which is needed for release of progeny virions from the infected cell. Other neuraminidase inhibitor includes Zanamivir & Peramivir. These are used against Flu Virus (Bird flu/swine Flu). Drugs like Amantadine and Rimantadine are viral uncoating inhibitors. Route of administration of neuraminidase inhibitors in influenza: Zanamivir: Inhalational Oseltamivir: Oral Peramivir: Intravenous