This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is not true regarding super-antigens - 
Select and explain. 
A. Bind T cells irrespective of antigen specificity of TCR, B. Bind directly to both MHC II and T cell receptor causing T cell activation, C. Bind to cleft (or antigen binding groov(e) in the MHC II molecule, D. Binds directly to lateral aspect of T cell receptor
C: Bind to cleft (or antigen binding groov(e) in the MHC II molecule
Answer: C: Bind to cleft (or antigen binding groov(e) in the MHC II molecule 
Explanation: Superantigens Superantigens are potent activators of T-lymphocytes. Superantigens stimulate very large numbers of T cells, without relation to their epitope specificity. This leads to an excessive and dysregulated immune response with release of cytokines IL - 1, IL - 2, TNF - a and IF - y. Superantigens are capable of activating up to 20% of the peripheral T-cell pool, where as conventional antigens activate < 1 in 10, 000. For superantigens, antigen specificity of TCR is not required.