This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.N.S., Subject name: Medicine
Neurofibrillary tangles and agarophilic plaque are character-istic feature of 
Select and explain. 
A. Alzheimers d/s, B. CJD, C. Hepatic encephalopathy, D. Parkinsonism
A: Alzheimers d/s
Answer: A: Alzheimers d/s 
Explanation: Ans a: Ref: Harrison 17th ed pg 2541The area affected in Alzheimer's d/s are hippocampus temporal cortex and nucleus basalis of mayemet Microscopic finding are neurofibrillary tangles and senile neuritic plaques Neuritic plaque contain a central core that contain A? amyloid) proteoglycans, apoE4, alpha 1 antichymotrypsin &other proteinsAccumulation of A-beta amyloid on cerebral arterioles is amyloid angi-opathy.NFT- are silver staining, twisted neurofilaments in neuronal cytoplasm which represent abnormally phosphorylated tau protein