This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Werner syndrome is characterized by: 
Select and explain. 
A. Defect in DNA polymerase & impaired cell replication, B. Defect in telomerase & predisposition to cancer, C. Defect in transcription with accumulation of abnormal proteins, D. Defect in DNA helicase & premature aging
D: Defect in DNA helicase & premature aging
Answer: D: Defect in DNA helicase & premature aging 
Explanation: Defect in DNA helicase & premature aging