This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Infectious Lung Disease: Pneumonia, Subject name: Pathology
Which of the following is true regarding non-specific interstitial pneumonia? 
Select and explain. 
A. Honeycombing on CT scan, B. More common in male smokers, C. Fibroblastic foci are characteristic, D. Most often associated with connective tissue disease
D: Most often associated with connective tissue disease
Answer: D: Most often associated with connective tissue disease 
Explanation: Non-specific interstial pneumonia (NSIP) Etiology most often a/w connective tissue disorder can be idiopathic C/F More likely in elderly female (non-smoker) Dyspnea, cough M/E Cellular pattern or Fibrosing pattern No fibroblastic foci No honey combing No granulomas or hyaline membranes B/L reticular opacities on HRCT present Cases with cellular pattern have a better prognosis.