This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anatomy
All of the following statements about paneth cells are true, except - 
Select and explain. 
A. Rich in Rough Endoplasmic reticulum, B. Rich in zinc, C. Contain Lysozyme, D. Foamy appearance
D: Foamy appearance
Answer: D: Foamy appearance 
Explanation: Foamy appearance or frothy cytoplasm is a feature associated with the presence of lipid/mucinous material in the cell cytoplasm. It is seen in mucous secreting goblet cells or lipid phagocytizing macrophage eg Touton giant cell (but not in paneth cells).
Paneth (zymogen) cells are rich in zinc, rough endoplasmic reticulum (RER) and secretory granules containing lysozyme, defensins or cryptidins such as TNF-a. It exceptionally migrate towards the base of the crypt of Lieberkuhn instead of going towards the tip of villi.