This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Haemoglobin F is raised in: 
Select and explain. 
A. Juvenile chronic myeloid leukemia, B. Hereditary spherocytosis, C. Congenital red cell aplasia, D. Mysthania gravis
A: Juvenile chronic myeloid leukemia
Answer: A: Juvenile chronic myeloid leukemia 
Explanation: Answer is A (Juvenile CML) Fetal Haemoglobin levels (HbF) are increased in most cases of Juvenile CML - Causes of Raised HbF levels (Interpretation of Diagnostic Test 8th/411, 412) Haemoglobinopathies - b thalassemia major - b thalassemia minor - Sickle cell disease Hereditary Persistance of HbF Anemia: - Non Hereditary refractory normoblastic anemia - Pernicious anemia - Aplastic anemia Leukemia specially Juvenile Myeloid Leukemia Multiple myeloma Molar pregnancy Patients with Trisomy 13 or Trisomy 21 (Down's syndrome) Some chronic viral infections (eg CMV, EBV)