This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Biochemistry
I-cell disease is associated with 
Select and explain. 
A. Golgi apparatus, B. Lysosomes, C. Peroxisomes, D. Mitochondria
B: Lysosomes
Answer: B: Lysosomes 
Explanation: Mutations in proteins of the plasma membrane, with one affecting lysosomal function (I-cell disease).I-cell disease - Mutations in the gene encoding GlcNAc phosphotransferase, resulting in absence of the Man 6-P signal for lysosomal localization of ceain hydrolases