This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Medicine
Function of infliximab used in Crohn&;s is 
Select and explain. 
A. Inhibit TNF-a, B. Inhibit IL-2, C. EGFR inhibitor, D. Inhibit VEGF
A: Inhibit TNF-a
Answer: A: Inhibit TNF-a 
Explanation: Infliximab, a chimeric IgG1 antibody against TNF-a, is approved for treatment of moderately to severely active UC.Infliximab is also effective in CD patients with refractory perianal and enterocutaneous fistulasAdalimumab and ceolizumab, golimumab are other Anti-TNF therapies approved for IBDInfliximab is also approved for psoriasis, psoriatic ahritis, ankylosing spondylitis, and rheumatoid ahritisRef: Harrison 19e pg: 1961