This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Baezomib is - 
Select and explain. 
A. Proteosome inhibitor, B. DNA methyl transferase inhibitor, C. Tyrosine kinase inhibitor, D. Histone deacylase inhibitor
A: Proteosome inhibitor
Answer: A: Proteosome inhibitor 
Explanation: Ans. is 'a' i.e., Proteosome inhibitor Proteosome inhibitors o Transcription factor NFKB is associated by an inhibitor IKB. o IKB is degraded by proteosomes. o Inhibition of proteosome prevents degradation of IKB which inhibits the overactivity of NFKB. o Proteosome inhibitor (Baezomib) is used in multiple myeloma.