This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Psychiatry
Which of the following anti - hypertensives was once used as an antipsychotic? 
Select and explain. 
A. Atenolol, B. Propranolol, C. Clonidine, D. Reserpine
D: Reserpine
Answer: D: Reserpine 
Explanation: Reserpine is an antihypertensive drug which was used as an antipsychotic. Antipsychotic effect of reserpine is due to depletion of 5 - HT or catecholamine or both.
Clonidine is also an antihypertensive. Its uses in psychiatry are - ADHD, opioid withdrawal, Tourette's syndrome and suppression of agitation in PTSD.