This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Orthopaedics
In rheumatoid arthritis, pathology starts in the - 
Select and explain. 
A. Articular cartilage, B. Capsule, C. Synovium, D. Muscles
C: Synovium
Answer: C: Synovium 
Explanation: Major target in RA is synovium (synovial membrane) of the joint where the pathology starts.
Inflammation starts in the synovium and later also causes cartilage damage and bone erosion with subsequent change in joint integrity.