This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
All of the following statements about Lipoprotein Lipase are true, Except : 
Select and explain. 
A. Found in adipose tissue, B. Found in myocytes, C. Deficiency leads to hyperiacylglycerolemia, D. Does not require CII as cofactor
D: Does not require CII as cofactor
Answer: D: Does not require CII as cofactor 
Explanation: D i.e. Does not require CII as cofactorIn the capillaries of adipose, hea, skeletal muscle and lactating mammary tissuesQ, lipoprotein lipase is activated by apo CII aproprotein of chylomicron and VLDLQ and the enzyme degrades the triacyl glycerol to yield fatty acid and glycerol.Apo CII is essential for activation whereas apo All and C III inhibits the lipoprotein lipase enzymeQ. So the patients with a deficient lipoprotein lipase or apo CII (i.e. Type I hyperlipoproteinemia or Familial lipoprotein lipase deficiency) show a very high (> 1000 mg/dl) accumulation of chylomicrons containing triacyl glycerol in plasma i.e. hyperiacylglycerolemia even in fasting stateQ.