This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
Most common dose limiting adverse effect of colchicine is: 
Select and explain. 
A. Sedation, B. Kidney damage, C. Diarrhea, D. Muscle paralysis
C: Diarrhea
Answer: C: Diarrhea 
Explanation: Colchicine is the most effective drug for acute attack of gout. However, it is used for patients not responding to NSAIDs because of its adverse effects. Diarrhea and myopathy are major adverse effects.