This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Pharmacology
Tolerance develops by which of the following drug: 
Select and explain. 
A. Calcium channel blockers, B. ACE inhibitors, C. Nitrates, D. K channel openers
C: Nitrates
Answer: C: Nitrates 
Explanation: Ans. C. NitratesTolerance develops to nitrates when they constantly present in blood. Therefore, it is preferred via sublingual route as it act for short period of time.