This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Clinical Trials, Subject name: Pharmacology
All are true about Phase II trials except: 
Select and explain. 
A. Safety and efficacy, B. Done in healthy human volunteers, C. Therapeutic exploratory trial, D. Positive evidence in Phase 1 is a prerequisite
B: Done in healthy human volunteers
Answer: B: Done in healthy human volunteers 
Explanation: Ans: B (Done in healthy human volunteers) Ref: Goodman and Gilman's "Pharmacological Basis of Therapeutics" 12th edExplanation:Phase II trial is done on Patients (Phase I done on healthy human volunteers)It is done for assessing the safety and efficacyIf Phase I trial indicates any serious adverse effects. Phase II cannot be donePositive evidence and absence of serious adverse effects from Phase I are prerequisite for proceeding with Phase II trial. (See the following table and figure)