This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
In thromboasthenia there is a defect in ? 
Select and explain. 
A. Platelet aggregation, B. Platelet adhesion, C. Decreased ADP release, D. Desordered platelet secretion
A: Platelet aggregation
Answer: A: Platelet aggregation 
Explanation: Ans. is 'a' i.e., Platelet aggregation Platelet adhesion o Platelet adhesion referes to the binding of platelets to subendothelial matrix. o Platelet membrane glycoprotein Ib-IX is essential for platelet adhesion to subendothelial matrix. Platelet aggregation Platelet aggregation referres to adherence of platelets to one another. Platelet membrane glycoprotein IM-11.1a helps in aggregation. Congenital dysfunction of platelet Bernard-soulier syndrome o Defect in platelet adhesion due to inherited deficiency of glycoprotein lb-IX. Glanzmann's thrombasthenia o Defect in platelet aggregation due to inherited deficiency of glycoprotein