This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
Which of the following is hepatitis B infection most commonly associated with 
Select and explain. 
A. PAN, B. SLE, C. Serum sickness-like syndrome, D. Polymyositis
C: Serum sickness-like syndrome
Answer: C: Serum sickness-like syndrome 
Explanation: Immune complex-mediated tissue damage appears to play a pathogenetic role in the extrahepatic manifestations of acute hepatitis B.The occasional prodromal serum sickness-like syndrome observed in acute hepatitis B appears to be related to the deposition in tissue blood vessel walls of HBsAg-anti-HBs circulating immune complexes, leading to activation of the complement system and depressed serum complement levels.Ref: Harrison; 19th edition; Page no: 2011