This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Treatment of multiple carboxylase deficiency – 
Select and explain. 
A. Biotin, B. Pyridoxine, C. Thiamine, D. Folic acid
A: Biotin
Answer: A: Biotin 
Explanation: Pathogenesis of multiple carboxylase deficiency 

Deficiency of either holocarboxylase synthase or biotinidase impaires biotin metabolism.
Biotin is a cofactor for various carboxylases in the body -
Impaired metabolism of biotin results in multiple carboxylase deficiency.
So, for the treatment of multiple carboxylase deficiency, biotin should be given.