This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Wrong about clonidine is ? 
Select and explain. 
A. Alpha 2 receptor agonist, B. First line for ADHD, C. Sudden withdrawal causes rebound hypeension, D. Controls loose motions due to diabetic neuropathy
B: First line for ADHD
Answer: B: First line for ADHD 
Explanation: Ans. is 'b' i.e., First line for ADHD o Behavioural therapy is the first line therapy for the treatment of ADHD. The first line drug for ADHD is Methylphenidate. Clonidine It acts (paial agonist) on areceptors, especially a2 in brainstem - Stimulation of a2A receptors in medulla (vasomotor centre) - decrease sympathetic outflow - fall in BP and bradycardia (also due to enhanced vagal tone). Uses of clonidine Hypeension Opioid withdrawal Menopausal syndrome Alcohol withdrawal Smoking cessation Loose motions in diabetic neuropathy