This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Epitheliod granuloma is caused by 
Select and explain. 
A. Neutrophils, B. Cytotoxic T cells, C. Helper T cells, D. NK cells
C: Helper T cells
Answer: C: Helper T cells 
Explanation: ref Robbins 7/e p 83 CD 4 hepler cells are involved in granuloma formation as it secreted lFN - gamma, IL 2 ,IL 12 Histiocytes (specifically macrophages) are the cells that define a granuloma. They often, but not invariably, fuse to form multinucleated giant cells (Langhans giant cell). The macrophages in granulomas are often referred to as "epithelioid".