This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
Earliest sign of systemic absorption of local anaesthetic is – 
Select and explain. 
A. Convulsions, B. Circulatory collapse, C. Circumoral numbness, D. Respiratory arrest
C: Circumoral numbness
Answer: C: Circumoral numbness 
Explanation: Manifestations of local anesthetic toxicity (including lidocaine & bupivacaine)

Early symptoms (Prodrome) Circumoral numbness, dizziness, tongue paresthesia, restlessness, tinnitus, agitation.
CNS symptoms :- These are biphasic i.e. excitation (convulsions, restlessness, agitation & tinnitus), followed by depression (drowsiness, disorientation, respiratory depression, unconsciousness).
Cardiovascular manifestations :- hypotension, cardiac arrest, coma.