This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Which set of hormones have nuclear receptor: 
Select and explain. 
A. Estrogen, Thyroxin & Glucagon, B. Estrogen, Thyroxin & TSH, C. Estrogen, TSH & Gonadotropin releasing hormone (GnRH), D. Retinoic acid, Thyroxin & Luteinizing hormone (LH)
D: Retinoic acid, Thyroxin & Luteinizing hormone (LH)
Answer: D: Retinoic acid, Thyroxin & Luteinizing hormone (LH) 
Explanation: D i.e. Testosterone, coisol & Estogen (nearest answer)Nuclear receptors (Steroid receptors) that bind specific ligands (eg estrogen) & alter the rate at which specific genes are transcribed or translate. (Lehninger)Group I hormones eg retinoic acid, estrogen, vitamin D, glucocoicoids etc bind to nuclear receptor (Harper)Glucagon, TSH, GnRH &LH all bind to cell surface receptorsThe steroid hormones (estrogen, progesterone, and coisol for example), retinoic acid and thyroid hormones exe at least pa of their effects by a mechanism fundamentally different from that of other hormones: they act in neucleus to alter gene expression (Lehninger-456)