This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Uveal tract, Subject name: Ophthalmology
Brushfield spot in iris is seen in - 
Select and explain. 
A. Neurofibromatosis, B. Down syndrome, C. Tuberous sclerosis, D. Toxoplasmosis
B: Down syndrome
Answer: B: Down syndrome 
Explanation: Brushfield spots are seen in Down syndrome. Pedunculated nodules are seen in Neurofibromatosis.