This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
Drug distribution is inversely propoional to 
Select and explain. 
A. Plasma protein binding, B. Lipid Solubility, C. fat layer in the body, D. structure of drug
A: Plasma protein binding
Answer: A: Plasma protein binding 
Explanation: The extent of distribution of a drug depends on its lipid solubility, ionization at physiological pH, the extent of binding to plasma and tissue proteins, differences in regional blood flow. If PPB is high VD is low, PPB is inversly propoional to vd drugs with low vd usually have high ppb ref; KD Tripathi pharmacology 6th edition (page no;18)