This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
All of the following are minor criteria for multiple Myeloma, Except 
Select and explain. 
A. Plasmacytosis 20%, B. Multiple lytic lesions, C. Plasmacytoma on tissue biopsy, D. Monoclonal Ig spike < 2g/dl for IgA and < 3.5 for IgG
C: Plasmacytoma on tissue biopsy
Answer: C: Plasmacytoma on tissue biopsy 
Explanation: Answer is C (Plasmacytoma on tissue biopsy) Plasmacytoma or tissue biopsy is a major criterion for diagnosis of multiple myeloma (and not a minor criterion)