This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In Peibaldism ? 
Select and explain. 
A. Inheritance pattern is autosomal dominant, B. Mutations of the KIT ligand, stem cell factor (SCF), C. Is associated with deafness, D. Is characterized by excess melanocytes in the affected area
A: Inheritance pattern is autosomal dominant
Answer: A: Inheritance pattern is autosomal dominant 
Explanation: Ans. is 'a' i.e., Inheritance pattern is autosomal dominantPiebaldism Hypopigmentation disorderCaused by absence of melanocytes in the affected area.Autosomal dominant inheritance.There is a defect in the KIT proto - oncogene that codes for the KIT receptor. Thus defect in melanocyte survival results in hypopigmentation.KIT receptor activation by KIT ligand/ Stem Cell Factor (SCF) results in phosphorylation and potentiation of MITE Potentiation of MITF activity is responsible for melanocyte survival during development.Clinical features Depigmented patches present on the ventral or lateral trunk and in mid extremities with sparing of hands and feet.Poliosis and white forelock may be associated. Deafness is not a feature.Piebaldism with deafness is referred to as Woolf syndrome.