This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
During the treatment of chronic myeloid leukemia, cytogenetic is least likely to occur with which one of the following modalities of treatment ? 
Select and explain. 
A. Hydroxyurea, B. Imatinib mesylate, C. Interferon-alpha, D. Bone marrow transplantation
A: Hydroxyurea
Answer: A: Hydroxyurea 
Explanation: None