This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Most impoant change to occur in irreversible cell injury - 
Select and explain. 
A. Decreased basophillia, B. Pyknosis, C. Accumulation of myelin figures, D. Membrane damage
D: Membrane damage
Answer: D: Membrane damage 
Explanation: Ans is 'd' i.e. Membrane damage Membrane damage is the central pathogenic process in irreversible injury.