This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Inflammation & Repair, Subject name: Pathology
Chronic granulomatous disease is due to deficiency of 
Select and explain. 
A. Opsonization, B. Oxydase, C. Lysozyme, D. Cytokines
B: Oxydase
Answer: B: Oxydase 
Explanation: (Oxydase): (153- Baveja 4th Microbiology)Chronic Granulomatous disease (CGD) is fatal genetic disorder, deficiency of NADPH oxidase. In these patients polymorphonuclear leucocytes phagocytose invading bacteria normally but are unable to kill ingested micro organism because engulfment of bacteria is not followed by activation of oxygen-dependent killing mechanism. The bacteria involved in the recurrent infections are catalase positive organisms such as staphylococci and coliforms Leucocytes from these patients fail to reduce nitroblue tetrazolium (NBT) during phagocytosis. This property has been used (NBT test) for diagnosis of CGD