This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetic and genetic disorders, Subject name: Pediatrics
Which of the following is not true regarding Ataxia telangiectasia? 
Select and explain. 
A. Mutations in 11q gene is implicated, B. Follows autosomal dominant mode of inheritance, C. Humoral and cellular immunodeficiency, D. Linked to adenocarcinomas
B: Follows autosomal dominant mode of inheritance
Answer: B: Follows autosomal dominant mode of inheritance 
Explanation: The mode of inheritance in Ataxia telangiectasia is autosomal recessive Ataxia Telangiectasia Gene involved: Mutation in the ATM gene mapped to the long arm of chromosome 11(11q22-23) Defective DNA repair, increased sensitivity to ionizing radiation Hypoplastic thymus Clinical Features : Progressive cerebellar ataxia Oculocutaneous telangiectasias Chronic sinopulmonary disease High incidence of malignancy: adenocarcinomas and lymphoreticular tumors(lymphoma, leukemia, and Hodgkin disease) Humoral and cellular immunodeficiency Raised alpha fetoprotein levels Ref: Nelson textbook of pediatrics 21st edition Pgno: 1117