This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
Which of the following antiepileptic agents acts on the GABAergic system to decrease the uptake of GABA into neurons and glial cells? 
Select and explain. 
A. Vigabatrin, B. Progabide, C. Gabapentin, D. Tiagabine
D: Tiagabine
Answer: D: Tiagabine 
Explanation: It potentiates GABA mediated neuronal inhibition by depressing GABA transpoer GAT 1 which removes synaptically released GABA into neurons and glial cells REF: KD TRIPATHI 8TH ED. page 421