This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Menopause and HRT, Subject name: Gynaecology & Obstetrics
Estrogen adminstration in a menopausal woman increase the: 
Select and explain. 
A. Gonadotropin secretion, B. LDL cholesterol, C. Bone mass, D. Muscle mass
C: Bone mass
Answer: C: Bone mass 
Explanation: Postmenopausal women are at a high risk for fracture of bones due to osteoporosis. PTH and IL-1 are involved. Estrogen prevents osteoporosis by inhibiting osteoclastic activity,and inhibits release of IL-1 by monocytes.Increases absorption of calcium from gut,stimulates calcitonin secretion from C cells of thyroid and increases 1,25-dihydroxyvitamin D. All these lead to increased bone mineralisation D.C DUTTA'S TEXTBOOK OF GYNAECOLOGY,7TH edition,Pg no:47