This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gastro Intestinal System, Subject name: Pediatrics
True about Wilson's disease is: 
Select and explain. 
A. Increased serum ceruloplasmin, B. Decreased liver copper, C. Increased urinary copper excretion, D. Decreased urine copper excretion
C: Increased urinary copper excretion
Answer: C: Increased urinary copper excretion 
Explanation: C. Increased urinary copper excretion(Ref: Nelson's 20/e p 1939-1940)In Wilson disease serum ceruloplasmin is decreased (<20mg/dL), "free" copper level may be elevated in early ds (>1.6mmol/L)Urinary copper excretion is increased to >100-1000mg/day & hepatic copper content is >250mg/g dry weight in Wilson disease