This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Antidepressant drug that can cause neuroleptic malignant syndrome and tardive dyskinesia is: March 2009 
Select and explain. 
A. Amineptin, B. Carbamazepine, C. Amoxapine, D. Trazodone
C: Amoxapine
Answer: C: Amoxapine 
Explanation: Ans. C: Amoxapine One of major metabolites of amoxapine, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome. Amoxapine is also associated with acute extrapyramidal symptoms and tardive dyskinesia.