This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Treatment of choice for choriocarcinoma: September 2009 
Select and explain. 
A. Observation, B. Hysterectomy, C. Chemotherapy with Methotrexate, D. Radiotherapy
C: Chemotherapy with Methotrexate
Answer: C: Chemotherapy with Methotrexate 
Explanation: Ans. C: Chemotherapy with Methotrexate Unlike other malignant lesions, the treatment of choriocarcinoma is mainly chemotherapy, both for the local and distant metastasis. Various combinations: MAC (Methotrexate, Actinomycin-D, Chlorambucil) M AA (Methotrexate/ Actinomvcin-D/ adriamycin)