This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
BRCA1 gene is located on? 
Select and explain. 
A. Chromosome 12, B. Chromosome 21, C. Chromosome 17, D. Chromosome 22
C: Chromosome 17
Answer: C: Chromosome 17 
Explanation: BRCA1 gene is located on the chromosome 17. Mutations in the BRCA1, BRCA2, account for 80% of cases of familial breast cancer. In addition to breast cancer, women with BRCA1 mutation have a substantially higher risk of epithelial ovarian cancers & men have a slightly higher risk of prostate cancer. Likewise mutation in the BRCA2 gene increase the risk of breast cancer in both men & women as well as cancer of the ovary, prostate, pancreas, bile ducts, stomach & melanocytes. Ref: Robbins Basic Pathology ed 8 pg 205.