This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Pathology
Von Willebrand&;s factor is synthesized in which one of the following - 
Select and explain. 
A. Vascular endothelium, B. Macrophages, C. Liver, D. Eosinophils
A: Vascular endothelium
Answer: A: Vascular endothelium 
Explanation: The Von willebrand factor is synthesized in the endothelial cells ,megakaryocytes and platelets While the principal site of synthesis of factor VIII is the liver Reference :textbook of Pathology ,7th edition ,Author: Harsha Mohan, page number 314.