This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pharmacology
Indomethacin reduce the diuretic action of furosemide by 
Select and explain. 
A. Preventing prostaglandin mediated heamodynamic actions, B. Blockade of furosemide action in loop of henle, C. Enhancing water reabsorption in distal tubule, D. Increasing aldosterone secretion
A: Preventing prostaglandin mediated heamodynamic actions
Answer: A: Preventing prostaglandin mediated heamodynamic actions 
Explanation: NSAIDS inhibit specifically PGE2, PGI2 synthesis in renal tubules effecting the hemodynamic changes done by Prostaglandins for water, sodium reabsorption Ref: katzung 12th ed, Autocoids.