This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pharmacology, Subject name: Pharmacology
Loading drug of dose primaraly depends on 
Select and explain. 
A. Volume of distribution, B. Clearance, C. Rate of administration, D. Half life
A: Volume of distribution
Answer: A: Volume of distribution 
Explanation: Loading dose; This is a single or few quickly repeated doses given in the beginning to attain target concentration rapidly. Loading dose =Target Cp * V /F Cp-concentration, V - the volume of distribution, F-oral bioavailabilityThus, the loading dose is governed only by V and not by Clearance or t1/2 Ref ; KD Tripathi Pharmacology 7th edition (page no;33)