This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Liver cirrhosis is associated with which type of emphysema in Pizz phenotype mutation? 
Select and explain. 
A. Centriacinar, B. Panacinar, C. Paraseptal, D. Multifocal
B: Panacinar
Answer: B: Panacinar 
Explanation: In individuals with the Pizz phenotype, alpha 1 antitrypsin deficiency, its blood levels are less than 15% of normal, and patients are likely to develop panacinar emphysema at a young age; 50% of these patients will develop liver cirrhosis, because the A1AT is not secreted properly and instead accumulates in the liver. A liver biopsy in such cases will reveal PAS-positive, diastase-resistant granules.