This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
A patient comes to you complaining that whenever he takes aspirin for headache, he develops severe shoness of breath. Which of the following may be paly responsible for this effect? 
Select and explain. 
A. Leukotrienes, B. Prostaglandin E, C. Thromboxane A2, D. Prostacyclin
A: Leukotrienes
Answer: A: Leukotrienes 
Explanation: Aspirin inhibits COX enzyme and results in the diversion of AA pathwaytowards LT synthesis. As LTs are powerful bronchoconstrictor agents, these may result in the shoness of breath in patients who are susceptible. Aspirin acetylated COX stas producing lipoxins (known as aspirin triggered lipoxins) that also have bronchoconstrictor propeies.