This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: RH Incompatibility, Subject name: Gynaecology & Obstetrics
In Rh negative mother, who has delivered a Rh positive baby, prophylactic anti-D is indicated: 
Select and explain. 
A. If the direct Coombs test is negative, B. If the indirect Coombs test is positive with rising titres, C. If the ICT is positive, D. As a routine procedure
A: If the direct Coombs test is negative
Answer: A: If the direct Coombs test is negative 
Explanation: Indirect coombs test is done in mother- if it is positive means that the mother has made the D antibody. Direct coombs test is done in baby - if it is positive it indicates antibodies to the Rh antigen is already made by the mother and are transferred to the baby. Giving an Anti_d to the mother is of no use anymore So in these conditions anti D antibody cannot be given.