This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Medicine
Alkaline phosphatase is decreased in- 
Select and explain. 
A. ypophosphatasia, B. Primary biliary cirrhosis, C. Hyperphosphatemia, D. Hepatitis A
A: ypophosphatasia
Answer: A: ypophosphatasia 
Explanation: due to excessive depletion of phosphate there occur decreased alkaline phosphatase ( Harrison 17 pg 2370)