This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Growth and development, Subject name: Pediatrics
Early epiphyseal closure is seen with _________ 
Select and explain. 
A. LH, B. FSH, C. Estrogen, D. Progesterone
C: Estrogen
Answer: C: Estrogen 
Explanation: The growth velocity decreases and may even be zero after epiphyseal fusion, that is, after growth plate closure in late pubey. Precocious pubey (PP) is a known cause of sho stature after earlier pubey due to premature closure of growth plates in long bones Precocious pubey may be due to increased estrogen . Ref : Nelson paediatrics Chapter : Growth and deve