This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
The most clinically significant skin eruption associated with M. pneumoniae infection is: 
Select and explain. 
A. Erythema multiforme major, B. Bullous eruptions, C. Toxic epidermal necrosis, D. Pyostomatitis vegetans
A: Erythema multiforme major
Answer: A: Erythema multiforme major 
Explanation: Erythema multiforme major (Stevens-Johnson syndrome) is the most clinically significant skin eruption associated with M. pneumoniae infection. Ref:Harrisons Principles of Internal Medicine, 18th Edition, Page 1418