This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
A 10 year old female patient complains of tiredness and shortness of breath. Patient is a known case of beta-thalassemia. Which of the following can cause this disease? 
Select and explain. 
A. Terminal base addition, B. Faulty splicing, C. Terminal base deletion, D. None of the above
B: Faulty splicing
Answer: B: Faulty splicing 
Explanation: Faulty splicing can cause diseases : Splicing of hnRNA has to be performed with precision to produce functional mRNA. Faulty splicing may result in diseases. A good example is one type of beta-thalassemia in humans. This is due to a mutation that results in a nucleotide change at an exon-intron junction. The result is a diminished or lack of synthesis of  beta-chain of hemoglobin and consequently the disease beta-thalassemia.
Satyanarayana- Biochemistry, 3rd edition, pg-549