This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
SMAC/DIABLO is a 
Select and explain. 
A. Anti apoptotic protein, B. Induces necrosis, C. Acts both as anti and pro apoptotic protein, D. Pro-apoptotic protein
D: Pro-apoptotic protein
Answer: D: Pro-apoptotic protein 
Explanation: Diablo homolog (DIABLO) is a mitochondrial proteinthat in humans is encoded by the DIABLO (direct IAPbinding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, ref Robbins 9/e p 19, and internet