This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
Which one of the following drugs exacerbate reflux esophagitis 
Select and explain. 
A. Cisapride, B. Chlorpropamide, C. Theophylline, D. Metoclopramide
C: Theophylline
Answer: C: Theophylline 
Explanation: Drugs that can increase acid reflux and worsen GERD include: Anticholinergics Tricyclic antidepressants Calcium channel blockers Nitrates Opioids Progesterone Quinidine Benzodiazepines Theophylline ref - Harrisons internal medicine 20e pg2215,2219