This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
Maintenance dose rate of a drug depends primarily on: 
Select and explain. 
A. Volume of distribution, B. Half life, C. Lipid solubility, D. Total body clearance
D: Total body clearance
Answer: D: Total body clearance 
Explanation: Maintenance dose rate = Clearance x Target Plasma concentration * Maintenance dose depends on clearance and target plasma concentration