This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
Unwinding of DNA is done by 
Select and explain. 
A. DNA polymerase, B. DNA primase, C. Helicase, D. DNA ligase
C: Helicase
Answer: C: Helicase 
Explanation: In addition to binding to the nucleosome, the H1 protein binds to the "linker DNA" (approximately 20-80 nucleotides in length) region between nucleosomes, helping stabilize the zig-zagged 30 nm chromatin fiber Ref-Sathyanarayana 4/e p360