This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Epilepsy, Subject name: Pharmacology
What is the mechanism of action of levetiracetam? 
Select and explain. 
A. Antagonist of GABAA receptor, B. Bind to synaptic vesicular protein SV2A, C. Inhibit voltage gated Ca+ channel, D. Inhibit Na+ channel
B: Bind to synaptic vesicular protein SV2A
Answer: B: Bind to synaptic vesicular protein SV2A 
Explanation: Levetiracetam is an anti-epileptic drug that works by binding to SV2A, a ubiquitous synaptic vesicle integral membrane protein, which functions as a positive effector of synaptic vesicle exocytosis. Binding to SV2A in the vesicle reduces the release of the excitatory neurotransmitter glutamate. It is used for treatment of focal seizures GTCS, JME