This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Genetics, Subject name: Pathology
Karyotyping is done in which phase of cell cycle: 
Select and explain. 
A. Anaphase, B. Metaphase, C. Telophase, D. S phase
B: Metaphase
Answer: B: Metaphase 
Explanation: Ans. (b) Metaphase(Ref: Robbins 9th/pg 158; 8th/pg 159)In KaryotypeChromosomes are examined after arresting dividing cells in metaphase with mitotic spindle inhibitors (e.g. N-diacetyl-N-methylcolchicine), followed by stainingResolution of Karyotyping: 2 to 5 million base pairs Q