This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
The drug antabuse acts by- 
Select and explain. 
A. Decreasing ethanol absorption, B. Enhancing urinary excretion of ethanol, C. Increasing pulmonary excretion of ethanol, D. Blocking metabolism of ethanol
D: Blocking metabolism of ethanol
Answer: D: Blocking metabolism of ethanol 
Explanation: Ans. is 'd' i.e., Blocking metabolism of ethanol o Antabuse (disulfiram) inhibits the enzyme alcohol dehydrogenase. o By inhibiting alcohol dehydrogenase antabuse (disulfiram) inhibits the metabolism (oxidation) of alcohol. o Disulfiram is used in psychologically dependent but not in physically dependent alcoholics.