This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Lesions caused by Entamoeba histolytica predominantly involve 
Select and explain. 
A. Caecum and large intestine, B. Duodenum, C. Stomach, D. Jejunum and Ileum
A: Caecum and large intestine
Answer: A: Caecum and large intestine 
Explanation: Trophozoites generally infect the large intestinal mucosa but under certain conditions they may perforate the gut and invade other organs (especially liver, lungs and brain). 
In many cases, the trophozoites remain confined to the intestinal lumen (noninvasive infection) of individuals who are asymptomatic carriers, passing cysts in their stool. 
In some patients the trophozoites invade the intestinal mucosa (intestinal disease), or, through the bloodstream, extraintestinal sites such as the liver, brain, and lungs (extra-intestinal disease), with resultant pathologic manifestations.

Ref :
https://www.cdc.gov/parasites/amebiasis/pathogen.html
http://parasite.org.au/para-site/text/entamoeba-text.html#:~:text=Host%20range%3A%20Entamoeba%20histolytica%20is,in%20tropical%20and%20subtropical%20countries.