This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Lipoproteins, Subject name: Biochemistry
Which of the following is a GM2 gangliosidosis? 
Select and explain. 
A. Sandhoff's disease, B. Niemann-Pick disease, C. Gaucher's disease, D. Fabry's disease
A: Sandhoff's disease
Answer: A: Sandhoff's disease 
Explanation: Sandhoff's disease and Tay-Sachs disease are GM2 gangliosidosis. GM2 Gangliosidoses Disease Deficient enzyme Lipid accumulating Clinical features Tay-Sachs disease Hexosaminidase A GM2 ganglioside Mental retardation, Blindness, Muscular weakness, Cherry-red spot Sandhoff disease b-Hexosaminidases A and B Macrocephaly Hyperacusis Cherry-red spot