This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Butterfly rash is typically seen in: 
Select and explain. 
A. Herpes simplex, B. Systemic lupus erythematosus, C. Scleroderma, D. None of the above
B: Systemic lupus erythematosus
Answer: B: Systemic lupus erythematosus 
Explanation: The cutaneous lesions of SLE consist of erythematous patches on the face that coalesce to form a roughly symmetrical pattern over the cheeks and across the bridge of the nose in form of 'Butterfly' distribution. When SLE involve the kidney, the glomerular capillaries shows fibrinoid thickening and produces characteristic 'wire loops', which may be sufficient to result in renal insufficiency.