This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacodynamics, Subject name: Pharmacology
All of the following statements regarding volume of distribution are true except: 
Select and explain. 
A. Half life is usually propoional to Vd, B. Calculated by t1/2 multiplied by log2, C. Skeletal muscle relaxants have low Vd, D. High plasma protein bound drugs have low Vd
B: Calculated by t1/2 multiplied by log2
Answer: B: Calculated by t1/2 multiplied by log2 
Explanation: Vd = Amount of drug given / Plasma concentration . So, option 'B' is wrong.t1/2 = (0.693 * Vd ) / Clearance * So, Half life is directly propoional to volume of distribution. * Skeletal muscle relaxants have low Vd so that they can't go to brain etc. * High plasma protein bound drugs are less distributed so less volume of distribution.