This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pathology
Atheromatous changes of blood vessels affects early which of the following organ? 
Select and explain. 
A. Kidney, B. Hea, C. Liver, D. Spleen
B: Hea
Answer: B: Hea 
Explanation: Large elastic aeries (e.g., aoa, carotid, and iliac aeries) and large and medium-sized muscular aeries (e.g., coronary, renal, and popliteal aeries) are the vessels most commonly involved by atherosclerosis. Accordingly, atherosclerosis is most likely to present with signs and symptoms related to ischemia in the hea, brain, kidneys, and lower extremities. Myocardial infarction (hea attack), cerebral infarction (stroke), aoic aneurysms, and peripheral vascular disease (gangrene of extremities) are the major clinical consequences of atherosclerosis. ( Robbins Basic Pathology, 9 th edition, page 342 )