This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Zero order kinetics occur in following drug with high dose 
Select and explain. 
A. Phenytoin and theophylline, B. Digoxin and prapranol, C. Amiloride and probenecid, D. Lithum and thiophylline
A: Phenytoin and theophylline
Answer: A: Phenytoin and theophylline 
Explanation: Phenytoin and thiophylline follows zero order kinetics with high dose as it follow linear with time Ref -KDT 6/e p31,138