This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Deficiencies in the enzyme glucose-6-phosphatase are likely to lead to which of the following? 
Select and explain. 
A. Decreased glucagon production, B. Decreased Skeletal Muscle Glycogen Accumulation, C. Hyperglycemia, D. Increased hepatic glycogen accumulation
B: Decreased Skeletal Muscle Glycogen Accumulation
Answer: B: Decreased Skeletal Muscle Glycogen Accumulation 
Explanation: Glucose-6-phosphate is required in the liver in order for this organ to supply the rest of the body with glucose that has been produced by hepatic gluconeogenesis or released from stored hepatic glycogen. A deficiency in glucose-6- phosphatase leads to the most common of the glycogen storage diseases, von Gierke's disease. This glycogen storage disease results from excess hepatic glucose-6-phosphate allosterically activating the beta form of glycogen synthase leading to increased incorporation of glucose into glycogen. Ref: Bender D.A., Mayes P.A. (2011). Chapter 20. Gluconeogenesis & the Control of Blood Glucose. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.