This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Clinically significant drug interaction occurs between pyridoxine and all the following drugs except - 
Select and explain. 
A. Isoniazid, B. Cyclosporine, C. Levadopa, D. Hydralazine
B: Cyclosporine
Answer: B: Cyclosporine 
Explanation: Ans. is 'b' i.e., Cyclosporine Drug interactions of pyridoxine o Isoniazid produces a pyridoxine deficiency state. o Hydralazine, cycloserine and penicillamine also interfere with pyridoxine ultization and action. Oral contraceptives reduce pyridoxal phosphate level in some women. Pyridoxine, by promoting formation of dopamine from levodopa in peripheral tissues, reduces its availability in brain. o 4-deoxypyridoxine is a pyridoxine (antagonist).