This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Specific test for gout is: 
Select and explain. 
A. Raised serum uric acid level, B. Raised uric acid in synol fluid of joint, C. Raised urea level, D. Raised urease enzyme level
B: Raised uric acid in synol fluid of joint
Answer: B: Raised uric acid in synol fluid of joint 
Explanation: B i.e. Raised uric acid in synol fluid of joint - Gout is a metabolic disorder of purine catabolismQ, and characterized by high level of uric acid in the blood . Uric acid is end product of purine catabolismQ - Pyrimidine nucleotide unlike purine rings can be opened & degraded to highly water soluble structure like, p- alanine, /3? amino isobutyrate, NH3 & CO2. Excess meabolism of pyrimidine therefore does not give rise to clinical manifestationQ Human catabolizes purine (Adenine & Guamine) to uric acid, which is relatively insoluble acid.