This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
Gastrointestinal stromal tumours arise form 
Select and explain. 
A. Paneth cells, B. Stave cells, C. Enterocytes, D. Interstitial cells of Cajal
D: Interstitial cells of Cajal
Answer: D: Interstitial cells of Cajal 
Explanation: Gastrointestinal stromal tumours (GISTs) may arise in anypa of the gastrointestinal tract but 50% will be found inthe stomach.They are now known to be a distinct tumor derived from the interstitial cells of Cajal,The tumours are universally associated with a mutation in thetyrosine kinase c-kit oncogene (CD 117). These tumours are sensitive to the tyrosine kinase antagonist imatinibBailey and Love 27e pg: 1139