This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
The following affects the duration of action of Local Anesthesia, except 
Select and explain. 
A. Protein binding capacity of Local Anesthetic, B. Addition of vasoconstrictor, C. Vasodilator activity of Local Anesthetic, D. Non-nervous tissue diffusibility
D: Non-nervous tissue diffusibility
Answer: D: Non-nervous tissue diffusibility 
Explanation: None