This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
Nicotine dependence 
Select and explain. 
A. Physical dependence > psychic dependence, B. Physical dependence < psychic dependence, C. Physical dependence = psychic dependence, D. No tolerance
B: Physical dependence < psychic dependence
Answer: B: Physical dependence < psychic dependence 
Explanation: (B) Physical dependence < psychic dependence PSYCHOACTIVE SUBSTANCE USE DISORDERSDrugUsual Route of AdministrationPhysical DependencePsychic DependenceTolerance1. AlcoholOral+ ++ ++2. OpioidsOral, Parental, Smoking+ + ++ + ++ + +3. Cannabis (Marihuana)Smoking Oral++ ++4. CocaineInhalation, Oral, Smoking Parental++ +--5. AmphetaminesOral, Parental+ ++ ++ + +6. Lysergic acidOral-++7. BarbituratesOral, Parental+ ++ ++ + +8. BenzodiazepinesOral, Parental+++9. Volatile solventsInhalation++ ++10. Phencyclidine (PCP)Smoking, Inhalation, Parental, Ora!+++11. CaffeineOral++ ++12. NicotineOral, Smoking++ ++-- = None; + = Probable/Little; + = Some / Mild; ++ = Moderate; +++ = Severe.