This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
HMG-CoA can be directly conveed to all except? 
Select and explain. 
A. Acetoacetate, B. Acetyl-CoA, C. Mevalonate, D. Aceto-acetyl CoA
D: Aceto-acetyl CoA
Answer: D: Aceto-acetyl CoA 
Explanation: Ans. is 'd' i.e., Aceto-acetyl CoA Acetoacetate & Acetyl - CoA are derived from HMG-CoA during ketogenesis by HMG-CoA lyase which breaks the HMG-CoA into acetoacetate and acetyl-CoA during ketogenesis.Mevalonate is formed directly from HMG-CoA in cholesterol synthesis.HMG-CoA is conveed to mevalonate by HMG-CoA reductase, the key regulatory enzyme of cholesterol synthesis.