This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Malignancy associated hypercalcemia is due to? 
Select and explain. 
A. Tumor lysis syndrome, B. Parathyroid related peptide, C. IL-7, D. IGF-b
B: Parathyroid related peptide
Answer: B: Parathyroid related peptide 
Explanation: Ans. is 'b' i.e., Parathyroid related peptide * Hypercalcemia is the most common paraneoplastic syndrome. Most commonly it is caused by parathyroid hormone-related peptide (PTHRP), followed by TNF-a, IL-1, and TGF. Lymphomas cause hypercalcemia due to secretion of 1, 25 dihydroxy vitamin D (Calcitriol).