This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Mycobacterial Diseases (TB, Leprosy and MAC), Subject name: Pharmacology
Rifampicin is a powerful enzyme inducer. It is most likely to induce the metabolism of which of the following anti-retroviral drugs? 
Select and explain. 
A. Tenofovir, B. Nevirapine, C. Abacavir, D. Zidovudine
B: Nevirapine
Answer: B: Nevirapine 
Explanation: Rifampicin is a microsomal enzyme inducer - increases several CYP450 isoenzymes, including CYP3A4 , CYP2D6, CYP1A2 and CYP2C subfamily. It thus enhances its own metabolism as well as that of many drugs including warfarin, oral contraceptives, coicosteroids, sulfonylureas, HIV protease inhibitors, non-nucleoside reverse transcriptase inhibitors (NNls), theophylline, metoprolol, fluconazole, ketoconazole, clarithromycin, phenytoin, etc. Among given options, Nevirapine (NNI) is the best answer.