This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous (Gynae), Subject name: Gynaecology & Obstetrics
Prevention of neural tube defect in the newborn is by 
Select and explain. 
A. Iron, B. B6, C. B12, D. Folic acid
D: Folic acid
Answer: D: Folic acid 
Explanation: (Folic acid): (865 H186th edition)* Folic acid supplementation of the time of conception and in the first 12 weeks of pregnancy reduce by -70% the incidence of neural tube defects (NTDs) (Anencephaly , meningomyelocele,encephalocele and spina bifida) in the fetus.* Most of this protective effect can be achieved by taking folic acid 0.4mg daily at the time of conception* The incidence of cleft palate and have lip also can be reduced by prophylactic folic acid* NTDs also can be caused by antifolate and antiepileptic drugs