This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of nucleic acids, Subject name: Biochemistry
A mutation that results in premature termination of incorporation of amino acid into a peptide chain is a 
Select and explain. 
A. Nonsense mutation, B. Transversion, C. Silent mutation, D. Frameshift mutation
A: Nonsense mutation
Answer: A: Nonsense mutation 
Explanation: In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and usually nonfunctional protein product. It differs from a missense mutation, which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders, such as thalassemia and DMD, result from nonsense mutations.