This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Menopause and HRT, Subject name: Gynaecology & Obstetrics
H is useful in all of the following except: 
Select and explain. 
A. Vaginal atrophy, B. Flushing, C. Osteoporosis, D. Coronary hea disease
D: Coronary hea disease
Answer: D: Coronary hea disease 
Explanation: Advantages of Estrogen in H: 1.prevents osteoporosis 2.decreases hot flushes 3.vaginal application of estrogen decreases vaginal atrophy Disadvantages of H: 1.Coronary Hea Disease 2.stroke 3.thromboembolic events 4.breast cancer 5.cholecystitis