This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Physiology
02 (oxygen) dissociation curve is shifted to right in the following except 
Select and explain. 
A. Rise in temperature, B. Hypercapnia, C. Riased 2, 3 DPG level, D. Metabolic alkalosis
D: Metabolic alkalosis
Answer: D: Metabolic alkalosis 
Explanation: When the free level falls as a result of addition of alkali, or more commonly, the removal of large amounts of acid (eg, following vomiting), metabolic alkalosis results. In uncompensated metabolic alkalosis the pH rises along the isobar line.Rise in pH shifts the curve to the leftA rise in temperature or a fall in pH shifts the curve to the rightRetention of CO2 in the body is called as hypercapnia. when the PCO2 rises, the curve shifts to the right An increase in the concentration of 2,3BPG shifts the reaction to the rightRef: Ganong's Review of Medical Physiology Twenty-Third Edition Page No:611