This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Syndrome associated with increased risk of leukemia is: 
Select and explain. 
A. Plummer Vinson syndrome, B. Klinefelter syndrome, C. Sturge Weber syndrome, D. Multiple hamartoma sydrome
B: Klinefelter syndrome
Answer: B: Klinefelter syndrome 
Explanation: Genetic disease association of Lympho-haematopoietic malignancies:
Acute leukaemia occurs with increased frequency with a variety of congenital disorders such as:

Down’s syndrome
Bloom’s syndrome
Klinefelter’s syndrome
Wiskott-Aldrich’s syndrome

Mohan H. Textbook of pathology. Jaypee Brothers Medical Publishers; 2015. Edition 7. Page 334