This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Radiology
Fraying and cupping of metaphyses of long bones in a child does not occur in: 
Select and explain. 
A. Rickets, B. Lead poisoning, C. Metaphyseal dysplasia, D. Hypophosphatasia
B: Lead poisoning
Answer: B: Lead poisoning 
Explanation: B i.e. Lead poisoning Remember : Lead poisoningQ (Bismuth, Arsenic, P, mercury fluride, radium also), Radiation & Hypervitaminosis D leads to solitary dense metaphyseal band not cupping & fraying. Causes of Cupping & Fraying of metaphysis Metaphyseal Cupping Metaphyseal Fraying RicketsQ (with widening & fraying of growth plate) 1. RicketsQ HypophosphatemiaQ 2. HypophosphatemiaQ Dysplasias of bone - (eg achondroplasia, pseudochondroplasia, metatropic dwarfism, diastrophic dwarfism, chondrodysplasias) 3. 4. Copper deficiency Chronic stress in the wrist of young gymnasts (with asymmetrical widening of distal radial Scurvy growth plate & metaphyseal sclerosis) Trauma Normal (distal ulna of proximal fibula)