This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immune system, Subject name: Medicine
Family of Toll-like receptors (TLRs) are? 
Select and explain. 
A. Most impoant for oncogene activation by virus and plays impoant role in cancer, B. Essential for glucose homeostasis, C. Most impoant for entry of retrovirus into the immune cells, D. Most impoant receptors for microbial products to initiate acute inflammation
D: Most impoant receptors for microbial products to initiate acute inflammation
Answer: D: Most impoant receptors for microbial products to initiate acute inflammation 
Explanation: Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.They are the Most impoant receptors for microbial products to initiate acute inflammation. Ref - Harrison's internal medicine 20e p1067,2511