This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
Multiple myeloma on radionuclide scanning presents as 
Select and explain. 
A. Cold nodule, B. Hot nodule, C. Diffuse increased uptake, D. Diffuse decreased uptake
A: Cold nodule
Answer: A: Cold nodule 
Explanation: Hot spots' or | distribution is seen inBone tumor or cancerBone metastasis from breast, lung, prostate, thyroid & kidney.Fracture, when it cannot be seen on a regular X-ray Bone injections (osteomyelitis)Cause of bone pain.Metabolic disorders such as osteomalacia, renal osteodystrophy, primary hyperparathyroidism, osteoporosis, complex regional pain syndrome &Paget's disease.(Refer: Sutton's Textbook of Radiology & Imaging, 7th edition, pg no:1251-1255)