This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc., Subject name: Medicine
Niemann - Pick disease is due to deficiency of which of the following enzymes? 
Select and explain. 
A. Acid Sphingomyelinase, B. Hexosaminidase A, C. Ceramidase, D. Arylsulfatase B
A: Acid Sphingomyelinase
Answer: A: Acid Sphingomyelinase 
Explanation: Deficient enzyme Disease Acid Sphingomyelinase Niemann pick disease Hexosaminidase A Tay-sachs disease Ceramidase Farber disease Arylsulfatase B Maroteaux - Lamy syndrome