This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
Sphingomyelinase deficiency is seen in 
Select and explain. 
A. Niemann - Pick disease, B. Farber's disease, C. Tay Sach's disease, D. Krabbe's disease
A: Niemann - Pick disease
Answer: A: Niemann - Pick disease 
Explanation: DiseaseEnzyme DeficiencyClinical SymptomsNiemann-PickdiseaseSphingomyelinaseEnlarged liver and spleen, mental retardation;fatal in early lifeRef: Harper&;s Biochemistry; 30th edition; Chapter 24; 24 Metabolism of Acylglycerols & Sphingolipids