This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Histamine, 5-HT and PGs, Subject name: Pharmacology
A night shift worker complains of profuse Rhinorrhea and Sneezing for the past few days . Which among the following drug can be given to him ? 
Select and explain. 
A. Promethazine, B. Fexofenadine, C. Chlorpheniramine, D. Pheniramine
B: Fexofenadine
Answer: B: Fexofenadine 
Explanation: 1st generation anti histamines 2nd generation anti histamines 1. Chlorphenaramine 2. Promethazine 3. Diphenhydramine 4. Cyclizine 5. Meclizine 6. phenaramine 1. Terfenadine 2. Fexofenadine 3. levocetrizine 4. Loratidine Note : All the 1st generation drugs can cross BBB and produce CNS actions so all 1st generation antihistamines can cause sedation. so 2nd generation antihistamines are given in this patients.