This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
Transfusion reactions are due to which type of hypersensitivity? 
Select and explain. 
A. Immediate, B. Immune complex-mediated, C. Antibody-mediated, D. Delayed-type
C: Antibody-mediated
Answer: C: Antibody-mediated 
Explanation: Type II: HypersensitivityType II hypersensitivity involves the binding of IgG antibodies to cell surface antigens or extracellular matrix molecules.Antibody-directed at cell surface antigens can activate complement to damage the cells. The result may be complement mediated lysis, which occurs in hemolytic anemia, ABO transfusion reactions, and Rh hemolytic diseaseRef: Jawetz; 27th edition; Page no: 145