This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pathology
Characteristic feature of Goodpasture's syndrome 
Select and explain. 
A. Lumpy-bumpy deposits on immunofluorescence, B. Serum antibodies against alpha 3 NC1 domain of collagen - IV, C. Serum antibodies against alpha 1 NCI domain of collagen III, D. Anti DNAse antibodies positive
B: Serum antibodies against alpha 3 NC1 domain of collagen - IV
Answer: B: Serum antibodies against alpha 3 NC1 domain of collagen - IV 
Explanation: Ans. (b) Serum antibodies against alpha 3 NC1 domain of collagen - IV(Ref: Robbins 9th/pg 912-913)Goodpasture syndromeIt is type 1 RPGN & a type II hypersensitivity reaction.It is characterized by serum antibodies against alpha 3 NC1 domain of collagen - IV.This shows linear GBM fluorescence, while all other Glomerulonephritis, which are type 3 Hypersensitivity reactions show granular immune deposits.