This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Sweaty feet odour in body fluids occur due to deficiency of 
Select and explain. 
A. Biotin, B. Isovaleryl-CoA dehydrogenase, C. Thiamine linked decarboxylase, D. Leucine transaminase
B: Isovaleryl-CoA dehydrogenase
Answer: B: Isovaleryl-CoA dehydrogenase 
Explanation: The impaired enzyme in isovaleric acidemia is isovaleryl-CoA dehydrogenase. Vomiting, acidosis and coma follow ingestion of excess protein. Accumulated isovaleryl-CoA is hydrolyzed to isovalerate and excreted. Characteristic odor of sweaty feet is present.
Harper's Illustrated Biochemistry 30 th edition page no 309