This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Transplantation, Subject name: Surgery
Contraindication of liver transplant? 
Select and explain. 
A. Acute fulminant hepatic failure, B. Metabolic Disease, C. Metastasis, D. Primary liver malignancy
C: Metastasis
Answer: C: Metastasis 
Explanation: Ans. (c) MetastasisRef: Sabiston 19th edition, Page 657* Contraindications for Liver transplant:# Metastatic liver disease# Poor cardio-pulmonary reserve# Systemic infections (HIV is not a contraindication now)# Porto pulmonary hypertension with pulmonary artery pressure >50mmHg # Hepatopulmonary syndrome when PaO2 does not show improvement with 100% oxygen.