This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Amyotrophic Lateral Sclerosis and other motor neuron diseases, Subject name: Medicine
Which of the following is FALSE regarding Neurofibromatosis inheritance: 
Select and explain. 
A. Von Recklinghausen's Disease is due to defect in chromosome 17, B. Autosomal dominant type of inheritance, C. NF-2 - Musculoskeletal deformities is characterstic, D. NF-1 - Most common single gene disorder affecting human nervous system.
C: NF-2 - Musculoskeletal deformities is characterstic
Answer: C: NF-2 - Musculoskeletal deformities is characterstic 
Explanation: NEUROFIBROMATOSIS (NF) NF - 1/Von Recklinghausen's Disease NF-2/Bilateral acoustic neurofibromatosis Most common single gene disorder affecting human nervous system. Peripheral neurofibromatosis, is due to defect in chromosome 17. AD inheritance 100% penetrance Due to defect in long arm of chromosome 22. AD inheritance Musculoskeletal deformities absent 8th nerve vestibular schwannomas Meningioma occur in 50% cases. Note: Usually Skeletal disorders are Autosomal Dominant and Inborn errors of metabolism are autosomal recessive