This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
All statements regarding ketamine are true except – 
Select and explain. 
A. May be arrythmogenic, B. Raised ICT do not respond to CO2 level, C. Vasodilator and negative ionotropic effect, D. Psychomimetic emergence
B: Raised ICT do not respond to CO2 level
Answer: B: Raised ICT do not respond to CO2 level 
Explanation: Cerebrovascular responsiveness to CO2 is preserved, and reducing the arterial CO2 tension by hyperventilation attenuates the ketamine induced rise in IOT.
Ketamine has direct myocardial depressant and vasodilator effect. It also has indirect sympathomimetic action which predominates over direct depressant and vasodilator action → usual response is raised BP, CO & HR.
Ketamine can cause arrhythmias as it sensitizes the heart to adrenaline.
It can produce emergence psychiatric reaction.