This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
What is the mechanism of action of Fluconazole? 
Select and explain. 
A. Inhibits fungal mitosis, B. Inhibits lanosterol 14 demethylase, C. Inhibits squalene epoxidase, D. Inhibit ß1,3 glucan synthase
B: Inhibits lanosterol 14 demethylase
Answer: B: Inhibits lanosterol 14 demethylase 
Explanation: Ref. KDT. Page. 793
Fluconazole

They inhibit the fungal cytochrome P450 enzyme ‘lanosterol 14-demethylase’ and thus impair ergosterol synthesis leading to a cascade of membrane abnormalities in the fungus.
lower affinity for mammalian CYP450 enzymes and lesser propensity to inhibit mammalian sterol synthesis – causes less side effects
It is a water-soluble triazole having a wider range of activity
Indications include cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immunocompromised patients, coccidioidal meningitis and histoplasmosis