This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
Drugs used in the treatment of pruritus in PBC? 
Select and explain. 
A. Rifampicin, B. Naltrexone, C. Cholestyramine, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: The main symptoms of PBC are fatigue and pruritus, and symptom management is impoant.Several therapies have been tried for treatment of fatigue, but none of them have been successful; frequent naps should be encouraged. Pruritus is treated with antihistamines, narcotic receptor antagonists (naltrexone), and rifampin. Cholestyramine, a bile salt-sequestering agent, has been helpful. Plasmapheresis has been used rarely in patients with severe intractable pruritus.Ref: Harrison&;s Principles of Internal Medicine; 19th edition; Chapter 365; Cirrhosis and Its Complications Page no: 2061