This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pancreas, Subject name: Pharmacology
Which one of the following statements about mechanism of action of Metformin is true? 
Select and explain. 
A. Stimulate glycogenolysis, B. Stimulate hepatic gluconeogenesis, C. Enhance glucose uptake by skeletal muscle, D. Release insulin from beta cells of pancreas
C: Enhance glucose uptake by skeletal muscle
Answer: C: Enhance glucose uptake by skeletal muscle 
Explanation: Metformin decrease blood glucose by activating AMPK (Adenosine Mono Phosphate-activated protein Kinase) that helps in Decreasing production by - Inhibiting gluconeogenesis - inhibiting glycogenolysis Increasing utilization by -Stimulation of glycolysis -Uptake of glucose by muscles and fat.