This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Proteins and Amino Acids, Subject name: Biochemistry
Tyrosinosis most common cause is: 
Select and explain. 
A. Fumarylacetoacetate hydrolase, B. Tyrosine transaminase, C. Parahydroxy phenyl pyruvate hydroxylase, D. Homogentisate oxidase
A: Fumarylacetoacetate hydrolase
Answer: A: Fumarylacetoacetate hydrolase 
Explanation: Ans. A. Fumaryl Acetoacetate HydrolaseTyrosinosis or Tyrosinemia most common type is Type I Tyrosinemia. The enzyme defect is Fumaryl Acetoacetate Hydrolase deficiency. Incidence is 1 in 1846 live birth. Type II and III Tyrosinemia is rare types.