This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
All of the following are recommendations for screening of lynch syndrome in women with endometrial cancer except 
Select and explain. 
A. Evidence of microsatellety instability, B. DNA mismatch repair protein loss, C. Endometrial cancer before 60 years of age, D. 1st or 2nd degree relative with known DNA mismatch repair gene mutation
C: Endometrial cancer before 60 years of age
Answer: C: Endometrial cancer before 60 years of age 
Explanation: Lynch syndrome Genetic Screening Recommendations
Patients with endometrial or colorectal cancer and tumor evidence of:
Microsatellite instability or 
DNA mismatch repair protein loss
Fisrt-degree relative with endometrial or colorectal cancer who was diagnosed:
Before age 60 years or 
Is at risk for Lynch syndrome based on personal and medical history.
First- or second-degree relative with a known DNA mismatch repair gene mutation.