This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
All the following are disease phenotypes of Prion diseases Except 
Select and explain. 
A. Creutzfeldt-Jakob disease, B. Gerstmann-Straussler- Scheinker syndrome, C. Fatal familial insomnia, D. Leigh syndrome
D: Leigh syndrome
Answer: D: Leigh syndrome 
Explanation: Prions are abnormal forms of a cellular protein that cause rapidly progressive neurodegenerative disorders that may be sporadic, familial or transmitted. Disease phenotypes include Creutzfeldt-Jakob disease (rapidly progressive dementia), Gerstmann-Straussler-Scheinker syndrome (progressive cerebellar ataxia) and fatal familial insomnia.Leigh syndrome is a disease of infancy characterized by lactic acidemia, an arrest of psychomotor development, feeding problems, seizures, extraocular palsies, and weakness with hypotonia.Ref: Robbins and Cotran Pathologic Basis of Disease; 9th edition; Chapter 28; The Central Nervous System; Page no: 1284