This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Misc. (R.B.C), Subject name: Pathology
Iron metabolism and regulation are important for RBC precursor cell. Which of the following helps in regulation of iron metabolism but is not specific for iron? 
Select and explain. 
A. Hepcidin, B. DMT-1, C. Ferroportin, D. Ferritin
B: DMT-1
Answer: B: DMT-1 
Explanation: Ans. (b) DMT-1(Ref: Wintrobe 13ed /pg 811; Robbin's 9th/649; Complete review of Pathology 1st/314)About DMT-1:Mucosal uptake of non-heme iron begins at brush border of mucosal cell, mediated by divalent metal ion transporter 1 (DMT1, also known as Nramp2, SLC11A2).Levels of DMT1 are markedly increased in iron-deficient animals.In addition to iron, DMT I has been shown to transport a variety of divalent metal ions, including Mn2+,Co2+,Cu2+,Zn2+,Cd2+, and Pb2+. (Hence non -specific)It acts as a proton symporter; protons accompany metal ions into the cell.Hepcidin: principal iron regulatory hormone; and is negatively regulates ferroportin on basolateral surface of enterocyte Q