This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
Digoxin toxicity is aggrevated by 
Select and explain. 
A. Hypokalemia, B. Hyperkalemia, C. Hypermagnesimaia, D. Hypocalcemia
A: Hypokalemia
Answer: A: Hypokalemia 
Explanation: Hypokalemia is usually observed with chronic toxicity or in patients taking diuretics; it reduces the rate of Na+/K+ ATPase pump turnover and exacerbates pump inhibition due to digitalis. Hyperkalemia is the usual electrolyte abnormality precipitated by digoxin toxicity, primarily in the acute setting Refer kDT 6/e p499