This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Medicine
Lysosomal Storage disorders are associated with 
Select and explain. 
A. Non-disease-specific physical findings, B. Loss of function, C. Enzyme assays not useful, D. Genetic testing is helpless
B: Loss of function
Answer: B: Loss of function 
Explanation: (B) Loss of function # Lysosomal storage disorders (LSDs) are inherited diseases characterized by lysosomal storage and dysfunction.> Loss of lysosomal function is associated with severe neurodegeneration, which is the prominent pathological hallmark of LSDs.> Physical findings are disease-specific, and enzyme assays or genetic testing can be used to make a definitive diagnosis.