This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which one of the following preferentially activates plasminogen bound to fibrin and avoids the systemic lytic state - 
Select and explain. 
A. Streptokinase, B. Aminocaproic acid, C. Tranexamic acid, D. Alteplase
D: Alteplase
Answer: D: Alteplase 
Explanation: Ans. is 'd' i.e., Alteplase o Alteplase, Reteplase and tenecteplase are recombinant t-PA. These are nonantigenic. They activate fibrin bound plasminogen only. o Streptokinase activates both free as well as fibrin bound plasminogen.