This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemolytic anemia, Subject name: Pediatrics
Best treatment for Sickle cell anemia is? 
Select and explain. 
A. Hydroxyurea, B. Sulphonamide, C. Iron Injection, D. Blood transfusion
A: Hydroxyurea
Answer: A: Hydroxyurea 
Explanation: - Hydroxyurea increases HbF levels - used for treatment of sickle cell anemia. Management of Sickle cell anemia: Avoid infections & prompt correction of any inflammation Pneumococcal & HIB vaccination early in life Acute painful crisis - vigorous hydration & analgesia Bone marrow transplantation, gene therapy Hydroxyurea for patients with severe symptoms