This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
The most impoant prognosis factor of carcinoma breast is 
Select and explain. 
A. Lymph node involvement, B. DNA content of tumor, C. Histologic subtype, D. Tumor grade
A: Lymph node involvement
Answer: A: Lymph node involvement 
Explanation: Spread to axillary nodes is the most impoant prognostic indicator. Age: Younger the age worser the prognosis. Stage I and II has got better prognosis. Sex: Carcinoma male breast has got worser prognosis compared to female breast. Because of early spread in carcinoma male breast. Atrophic scirrhous has got best prognosis. Medullary carcinoma has got better prognosis than scirrhous carcinoma because of lymphocytic infi ltration. Invasive carcinoma has got worser prognosis. Inflammatory carcinoma breast has worst prognosis. Ref; (page no;559 ) 5th edition of SRB&;S manual of Surgery .