This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Malabsorbtion Syndrome, Subject name: Medicine
Cobble stone appearance on Barium enema of a neonate is a feature of? 
Select and explain. 
A. Hirschsprung disease, B. Anorectal malformation, C. Mucoviscidosis, D. Patent allantois
A: Hirschsprung disease
Answer: A: Hirschsprung disease 
Explanation: Hirschsprung's disease (Aganglinosis) Cobble stone appearance on Barium enema of neonate At Rectosigmoid Junction Dx- Gastrogaffin enema-Retention of contrast in distal pa of colon Screening test- Rectal manometry. IOC - Biopsy Rx - Svenson / Duhamel procedure Anorectal malformation cannot be detected on Barium enema Patent allantois causes urachal Fistula not dx on Barium enema Mucoviscidosis -presentation of cystic fibrosis H/O meconium ileus: