This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Central Nervous system, Subject name: Pharmacology
All are true about ramelteon except: 
Select and explain. 
A. Agonist at MT1 and MT2 receptors, B. Is a substrate of CYP1A2, C. Has high addiction liability, D. Approved for treatment of insomnia
C: Has high addiction liability
Answer: C: Has high addiction liability 
Explanation: Ref:katzung 11/e p374 Ramelteon is non-addictive drug. Ramelteon, marketed as Rozerem among others, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors, such as with drugs like zolpidem. Ref: KD Tripathi 8th ed.