This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Surgery
A 12-year-old boy with sickle cell disease presents with pain and swelling of the right lower extremity. A bone scan reveals osteomyelitis of the tibial diaphysis. An organism found more commonly than in the general population in these cases is: 
Select and explain. 
A. influenzae, B. Salmonella species, C. Klebsiella species, D. Bacteroides species
B: Salmonella species
Answer: B: Salmonella species 
Explanation: Although S. aureus is the most common organism found in osteomyelitis associated with sickle-cell disease, nontyphoid salmonella species are often found. Salmonella bacteria are thought to escape from the colonized colon due to microvascular infarcts secondary to sickle-cell disease. They then seed the bone via hematogenous spread.