This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Which of the following test has highest detection rate for Down's syndrome 
Select and explain. 
A. Maternal serum AFP, B. Integrated screening, C. Quadruple marker test, D. hcG levels
B: Integrated screening
Answer: B: Integrated screening 
Explanation: Integrated screening combines first and second trimester tests.
This includes fetal Nuchal Translucency at 11 - 14 weeks + Quadruple markers at 15 - 20 weeks.