This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-HIV Drugs, Subject name: Pharmacology
Which of the following statement is true regarding Atazanavir:- 
Select and explain. 
A. Effective against only HIV-1, B. Resistance is due to mutation in codon 50 isoleucine to valine substitution, C. Decrease cholesterol and triglyceride levels, D. Combination with ritonavir do not have any advantage
B: Resistance is due to mutation in codon 50 isoleucine to valine substitution
Answer: B: Resistance is due to mutation in codon 50 isoleucine to valine substitution 
Explanation: Atazanavir is effective against both against HIV 1 and HIV 2 but NNI are effective only against HIV 1. They do not decrease cholesterol and triglyceride levels. Combination with ritonavir have an advantage due to the phenomenon of Ritonavir boosting. The resistance is due to mutation in codon 50 isoleucine to valine substitution.