This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Concepts, Subject name: Pathology
Arrange the steps in oncogenesis in the sequence: 1. increased activity of telomerase2. angiogenesis3. Evasion of host defense 4. Activation of proto-oncogene 5. Warburg effect 
Select and explain. 
A. 3-5-4-2-1, B. 4-5-1-2-3, C. 1-2-3-4-5, D. 4-5-3-2-1
B: 4-5-1-2-3
Answer: B: 4-5-1-2-3 
Explanation: All cancers display eight fundamental changes in cell physiology, which are considered the hallmarks of cancer: * Self-sufficiency in growth signals* Insensitivity to growth-inhibitory signals* Altered cellular metabolism* Evasion of apoptosis* Limitless replicative potential (immoality)* Sustained angiogenesis* Invasion and metastasis* Evasion of immune surveillance