This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: JIPMER 2018, Subject name: Biochemistry
Patient presents with inability to conve pyruvate to Acetyl CoA. Which of the following can be given in treatment:- 
Select and explain. 
A. Vitamin B3, B. Thiamine B1, C. Free fatty acids, D. Biotin
B: Thiamine B1
Answer: B: Thiamine B1 
Explanation: PDH COMPLEX - three enzymes (1 ) pyruvate dehydrogenase (E1), (2) dihydrolipoyl transacetylase (E2) (3) dihydrolipoyl dehydrogenase (E3) FIVE COENZYME - VITAMIN B1 , B2 , B3 , B5 , COA, LIPOIC ACID Any oxidative decarboxylation reaction in body require vitamin B1 so here answer is the vitamin b1