This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
with worst prognosis- 
Select and explain. 
A. 8/21 translocation, B. Inversion 16, C. Normal cytogenetics, D. Monosomy 7
D: Monosomy 7
Answer: D: Monosomy 7 
Explanation: Monosomy 7 or paial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia (MDS) and acute myelogenous leukemia (AML) has worst prognosis Ref Davidson 23rd edition pg 789