This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
Isoniazide is metabolized by - 
Select and explain. 
A. Acetylation, B. Oxidation, C. Reduction, D. Hydrolysis
A: Acetylation
Answer: A: Acetylation 
Explanation: Ans. is 'a' i.e., Acetylation o Isoniazid is extensively metabolized in liver most important pathway being N - acetylation by NAT 2. The acetylated metabolite is excreted in urine.Drugs metabolized bv acetylationo Sulfonamides (including dapson)o INHo Procainamideo Hydralazineo PASo Clonazepam {given in 6th/e)