This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Dental
Which concept was put forth by Pettenkofer in (1819-1901) 
Select and explain. 
A. Ecological concept, B. Holistic concept, C. Multifactorial causation, D. Biomedical Concept
C: Multifactorial causation
Answer: C: Multifactorial causation 
Explanation: Multifactorial Causation
This concept was put forth by Pettenkofer of Munich (1819-1901). "Modern" diseases of civilization like coronary heart disease and cancers could not be explained on the basis of the 'single cause idea', because they were due to multiple factors. This concept offers multiple approaches for the prevention of disease.