This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Urology, Subject name: Surgery
Nigro protocol is for which carcinoma 
Select and explain. 
A. Anal, B. Colon, C. Hepatocellular, D. Pancreatic
A: Anal
Answer: A: Anal 
Explanation: Nigro protocol or Nigro Regime for Anal Carcinoma (Norman Nigro, et al 1974):  * Initial radiotherapy for 3 weeks 3000 rads (30 Gy total) to perineum and pelvis  * Then chemotherapy--5 FU, for 4-5 days; is a radiosensitizer, staed on 1st day of as 1000 mg/m2 continuous infusion. Mitomycin C is 15 mg/m2 as single dose on 1st day of  * Later after 3 weeks abdominoperineal resection (APR) with colostomy in case of persistent or recurrent disease. Reference : page 987 SRB's manual of surgery 5th edition