This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The subtype of Hodgkin's disease, which is histogenetically distinct from all the other subtypes, is - 
Select and explain. 
A. Lymphocyte predominant, B. Nodular sclerosis, C. Mixed cellularity, D. Lymphocyte depleted
A: Lymphocyte predominant
Answer: A: Lymphocyte predominant 
Explanation: Hodgkin's lymphoma can be divided into two groups.

1. Classical Hodgkin lymphoma

This group includes


Nodular sclerosis  (iii) Lymphocyte-rich
Mixed cellularity    (iv) Lymphocyte-depletion


The Reed-Sternberg cells have similar immunophenotype, i.e., express CD 15 and CD 30.

2. Lymphocytic predominance Hodgkin lymphoma

The Reed sternberg cells express CD 20 marker, characteristic B-cell immunotype.