This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Anticentromere antibodies are most commonly associated with : 
Select and explain. 
A. Diffuse cutaneous systemic sclerosis, B. Mixed connective tissue disease, C. CREST syndrome, D. Polymyositis
C: CREST syndrome
Answer: C: CREST syndrome 
Explanation: Answer is C (CREST syndrome): Anticentromere antibodies are characteristic of CREST syndrome. Anticentromere antibodies are present in 40 - 80% of patients with limited cutaneous scleroderma or crest syndrome. Anticentromere antibodies are found in only about 2% to 5% of patients with diffuse cutaneous scleroderma, and rarely in other connective tissue disease.-