This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
True statement regarding development of drug resistance in MRSA is 
Select and explain. 
A. Results due to pencillinase enzyme production, B. Occurs due to change in penicillin -binding proteins, C. Chromosome mediated, D. Treated with amoxicillin +clavulanix acid
B: Occurs due to change in penicillin -binding proteins
Answer: B: Occurs due to change in penicillin -binding proteins 
Explanation: Ref Katzung 11/e p776 Methicillin resistance occurs due to altered PBPs6, thus no penicillin (infant no beta lactam antibiotic) is useful against Methicillin -resistant Staphylococcus Audrie infections