This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
Which of the following is the longest acting Beta-blocker 
Select and explain. 
A. Esmolol, B. Sotalol, C. Carvedilol, D. Nadalol
D: Nadalol
Answer: D: Nadalol 
Explanation: Nadolol is a non-selective b-adrenergic antagonist that lacks intrinsic sympathomimetic activity and membrane-stabilizing propeies. Graeme Alexander, in Clinical Pharmacology (Eleventh Edition), 2012