This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Schizophrenia Spectrum and Other Psychotic Disorders, Subject name: Psychiatry
The major difference between typical and atypical antipsychotics is that 
Select and explain. 
A. The latter cause minimal or no increase in prolactin, B. The former cause tardive dyskinesia, C. The former are available as parenteral preparations, D. The latter cause substantial sedation
B: The former cause tardive dyskinesia
Answer: B: The former cause tardive dyskinesia 
Explanation: The most impoant reason to classify the antipsychotics in typical and atypical agents is the occurrence of extrapyramidal symptoms. Typical antipsychotics have significant extrapyramidal symptoms such as parkinsonism, acute muscle dystonia and tardive dyskinesia. These side-effects are negligible or minimal with atypical agents like clozapine, olanzapine and risperidone.