This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Metabolism of lipid, Subject name: Biochemistry
Tangier disease is due to deficiency of 
Select and explain. 
A. LDL, B. HDL, C. VLDL, D. Chylomicrons
B: HDL
Answer: B: HDL 
Explanation: Name Defect Remarks Familial alpha-lipoprotein deficiency Tangier disease Fish-eye disease apo-A-I deficiencies All have low or near absence of HDL Tendency toward hyperiacylglycerolemia as a result of absence of apo C-ll, causing inactive LPL. Low LDL levels. Atherosclerosis in the elderly. Reference: Harper; 30th edition; Page no: 275