This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
Breast conservation surgery is contraindicated in 
Select and explain. 
A. Tumor > 4 cm, B. Multicentric tumor, C. Axillary LN involvement, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: .Contraindications * Tumour > 4 cm * Positive axillary nodes > N1 * Tumour margin is not free of tumour after breast conservative surgery needs MRM * Poorly differentiated tumour * Multicentric tumour * Tumour/breast size ratio is more (centeral tumour) * Tumour beneath the nipple * Extensive intraductal carcinoma Ref; (page no;553 ) 5th edition of SRB&;S manual of Surgery