This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Skin, Bones and Joints, Subject name: Pathology
Which of the following is the most specific test for Rheumatoid ahritis: 
Select and explain. 
A. Anti-CCP antibody, B. Anti Igm antibody, C. Anti IgA antibody, D. Anti IgG antibody
A: Anti-CCP antibody
Answer: A: Anti-CCP antibody 
Explanation: RF and anti-CCP antibodies, may be found in sera from patients many years before clinical disease can be detected