This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General Concepts, Subject name: Pathology
Cell-matrix adhesions are mediated by? 
Select and explain. 
A. Cadherins, B. Integrins, C. Selectins, D. Calmodulin
B: Integrins
Answer: B: Integrins 
Explanation: The cell adhesion molecules (CAMs) are classified into four main families:- * Immunoglobulin family CAMs *Cadherins * Integrins: bind to extracellular matrix (ECM) proteins such as fibronectin, laminin, and osteopontin providing a connection between cells and extracellular matrix (ECM) * Selectins