This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pathology
Chromosomal mutation in low grade transitional cell cancer of bladder is? 
Select and explain. 
A. P53, B. Rb gene, C. FGFR3, D. HRAS
C: FGFR3
Answer: C: FGFR3 
Explanation: Ans. (c) FGFR3(Ref: Robbins 9th/968)*Noninvasive high-grade urothelial carcinoma is associated with loss of the TP53 and RB tumor suppressor genes while Noninvasive low-grade papillary urothelial carcinoma is associated with gain of function FGFR3 and HRAS mutations.