This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
Carbonic anhydrase inhibitor should not be given in: 
Select and explain. 
A. Sulfonamide hypersensitivity, B. Glaucoma, C. High altitude sickness, D. Epilepsy
A: Sulfonamide hypersensitivity
Answer: A: Sulfonamide hypersensitivity 
Explanation: Adverse effects of CA inhibitors: Acidosis, hypokalaemia, drowsiness, paresthesias, fatigue, abdominal discomfo. Hypersensitivity reactions-fever, rashes, sulphonamides also cause hypersensitivity reactions. so the combination of these two drugs is not recommended Bone marrow depression is rare but serious. It is contraindicated in liver disease: may precipitate hepatic coma by interfering with urinary elimination of NH3 (due to alkaline urine). Acidosis is more likely to occur in patients of COPD. REF-Essentials of Medical Pharmacology, K.D Tripathi,6th edition, page 569