This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autonomic nervous system, Subject name: Pharmacology
Which of the following antiglaucoma medications are not safe in infants 
Select and explain. 
A. Timolol, B. brimonidine, C. Latanoprost, D. Dorzolamide
B: brimonidine
Answer: B: brimonidine 
Explanation: Apraclonidine and brimonidine can cross blood brain barrier and can cause CNS depression and Apnea in neonates. therefore these are contraindicated in children less than 2 years of age Refer Goodman and Gilman 12e p1788,kdt 6/e 168