This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Periapical granuloma is mainly composed of: 
Select and explain. 
A. Macrophages, B. Lymphocytes, C. Plasma cells, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: The apical periodontal cyst is histologically identical with the periapical granuloma, from which it is actually derived, except for the presence of the epithelium-lined lumen. 
The lesion is predominantly composed of plasma cells that are mixed with macrophages and lymphocytes with endothelial cells and fibroblasts.
Periapical granuloma is not a true granuloma due to the fact that it does not contain granulomatous inflammation; however, periapical granuloma is a common term used.
Reference: Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 78