This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Specific Cytogenetic Disorders, Subject name: Pathology
A baby born to a couple who are 45 years each is at higher risk of development of: 
Select and explain. 
A. Down syndrome, B. Marfan syndrome, C. Klinefelter syndrome, D. Osteogenesis imperfecta
C: Klinefelter syndrome
Answer: C: Klinefelter syndrome 
Explanation: Klinefelter syndrome Male hypogonadism that occurs when there are two or more X chromosomes and one or more Y chromosomes. Elderly maternal and paternal age are associated with multiple genetic condition. Due to defective gametogenesis which has higher chance of occurrence in older age. Age Syndrome Older age of father and mother Klinefelter Syndrome Older mother Down syndrome Older father Marfan Osteogenesis imperfecta Neurofibromatosis Achondroplasia