This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
A highly ionized drug 
Select and explain. 
A. Is excreted mainly by kidney, B. Can carry placental barrier easily, C. Is well absorbed from intestine, D. Accumulates in cellular lipids
A: Is excreted mainly by kidney
Answer: A: Is excreted mainly by kidney 
Explanation: Ionized molecules cannot cross the biological membranes .therfore they are less likely to be absorbed . Entry of the molecules through blood brain barrier and blood placental barrier is also restricted .these drugs cannot be reabsorbed in the nephron,thus are excreted by the kidney . Refer kDT 7/e p29