This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Medical Illness Complicating Pregnancy, Subject name: Gynaecology & Obstetrics
Itching during cholestasis of pregnancy is due retained : 
Select and explain. 
A. Bilirubin, B. Bile acids, C. Alkaline phosphatase, D. Bile salts
D: Bile salts
Answer: D: Bile salts 
Explanation: Intrahepatic cholestasis and pruritus gravidarum Results from retained bile salts. Linked to high circulating levels of estrogen, which inhibit intraductal transpo of bile acids. Rx - Ursodeoxycholic acid