This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Small Intestine Malabsorption disorders, Subject name: Pathology
Anti trans glutaminase antibodies are seen in 
Select and explain. 
A. Celiac sprue, B. Tropical sprue, C. Crohn's disease, D. Familial adenomatous polyposis
A: Celiac sprue
Answer: A: Celiac sprue 
Explanation: - Celiac sprue is associated with Anti-tissue transglutaminase Ab Anti-endomysial Ab Anti-gliadin Ab OTHER OPTIONS: - Tropical sprue is infectious disease most commonly caused by E.coli involving complete small intestine resulting in iron, folic acid & vit B12 deficiencies - Crohn's disease is inflammatory bowel disease associated with Anti-Saccharomyces cerevisiae Antibody - Familial adenomatous polyposis is autosomal dominant disorder caused by germline mutation in APC gene resulting in multiple polyps in GI tract.