This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hemoglobinopathies: Sickle cell anemia, Subject name: Pathology
Autosplenectomy is seen in: 
Select and explain. 
A. Hereditary spherocytosis, B. Sickle cell disease, C. Thalassaemia, D. Autoimmune anemia
B: Sickle cell disease
Answer: B: Sickle cell disease 
Explanation: - In sickle cell anemia initially, congestive splenomegaly is seen. - Later, sickled RBC causes aerial occlusion - ischemic damage to spleen - resulting in Fibrosis of spleen / autosplenectomy.