This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bilirubin Metabolism, Subject name: Pathology
Primary biliary cirrhosis is most commonly associated with______ 
Select and explain. 
A. Systemic sclerosis, B. Sjogren syndrome, C. Ulcerative colitis, D. Pancreatitis
B: Sjogren syndrome
Answer: B: Sjogren syndrome 
Explanation: Primary Biliary Cirrhosis Autoimmune disorder Clinical manifestation - obstructive jaundice F > M Antibody seen in antimitochondrial ab which is formed against E2 subunit of PDH enzyme. Interlobular bile ducts are actively destroyed by lymphoplasmacytic inflammation with or without granulomas.