This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Vascular surgery, Subject name: Surgery
Intermittent claudication is defined as 
Select and explain. 
A. Pain in muscle at rest only, B. Pain in muscle on first step, C. Pain in muscle on exercise only, D. Pain in muscle on last step
C: Pain in muscle on exercise only
Answer: C: Pain in muscle on exercise only 
Explanation: Intermittent claudication occurs as a result of anaerobic muscle metabolism and is classically described as debilitating cramp-like pain felt in the muscles that is: * reliably brought on by walking; * not present on taking the first step (unlike osteoahritis); * reliably relieved by rest both in the standing and sitting positions; usually within 5 minutes So the best answer is c. Reference: Bailey and love, 27th edition, page number:943