This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immune system, Subject name: Medicine
Macrophage activation syndrome IS seen in association with? 
Select and explain. 
A. Systemic sclerosis, B. Sweet's syndrome, C. Polyaeritis nodosa, D. SLE
D: SLE
Answer: D: SLE 
Explanation: Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease that, for unknown reasons, occurs much more frequently in individuals with systemic juvenile idiopathic ahritis (SJIA) and in those with adult-onset Still disease. Macrophage activation syndrome is characterized by pancytopenia, liver insufficiency, coagulopathy, and neurologic symptoms and is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages, leading to widespread hemophagocytosis and cytokine overproduction . Ref - reseaechgate.net