This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Orthopaedics
True about Osteomyelitis 
Select and explain. 
A. X-ray changes seen after 24 hours, B. MRI changes seen in < 6 hours, C. First X-ray change seen is sclerosis at metaphysis, D. Bone scan shows increased activity
C: First X-ray change seen is sclerosis at metaphysis
Answer: C: First X-ray change seen is sclerosis at metaphysis 
Explanation: First X-ray changes seen in loss of soft tissue plane.