This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti-Ulcer, Subject name: Pharmacology
Sucralfate 
Select and explain. 
A. Reduces gastric acid secretion, B. Neutralises gastric acid, C. Is ulcer protective, D. Isanti H. pylori drug
C: Is ulcer protective
Answer: C: Is ulcer protective 
Explanation: Ans. is 'c' i.e., Is ulcer protective Sucralfateo Sucralfate is an ulcer protective agent. It preferentially and strongly adheres to the ulcer base, specially duodenal, and acts as a physical barrier preventing acid, pepsin and bile from coming in contact with the ulcer base. However, this protective action is attributed to sucralfate because of certain properties which are achieved only in acidic medium:Acidic medium gives it a viscous consistency, alsoIt polymerises at pH < 4 by cross linkages of molecule assuming sticky gel like consistency,o It is this viscous and gel like properties that are responsible for its action.o When antacids are given concurrently they raise the pH of gastric secretion and this interferes with the very basic mechanism of action of sucralfate (requires pH < 4) and thus makes them ineffective.