This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pharmacology
Which of the following drug is responsible for extrapyramidal side effects? 
Select and explain. 
A. Metoclopramide, B. Cisapride, C. Domperidone, D. All of the above
A: Metoclopramide
Answer: A: Metoclopramide 
Explanation: Ans. A. MetoclopramideMetoclopramide and domperidone both block the D2 receptor. Metoclopramide can cross the BBB whereas domperidone do not cross. So extrapyramidal side effects are seen with Metoclopramide.