This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Serum amyloid associated protein is increased in? 
Select and explain. 
A. Alzheimer’s disease, B. Ankylosing spondylitis, C. Chronic renal failure, D. Malignant hypertension
B: Ankylosing spondylitis
Answer: B: Ankylosing spondylitis 
Explanation: Secondary Amyloidosis (Reactive Systemic Amyloidosis) is associated with amyloid deposits that are composed of Amyloid Associated Protein (A Protein).
It is seen in

a) Chronic inflammatory conditions like RA (most common), TB & leprosy, osteomyelitis, ankylosing spondylitis, IBD (Crohn’s disease, UC), bronchiectasis.
b) Some tumors like Renal cell carcinoma (hypernephroma), Hodgkins lymphoma.

SAA is produced in the liver as an acute phase reactant in the inflammatory process.
The SAA is released into the circulation as an amyloid precursor and is transformed to A amyloid in lysosomes of macrophages and other cells of the reticuloendothelial system.