This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Childhood Tumors, Subject name: Pediatrics
Retinoblastoma gene is located on: 
Select and explain. 
A. Chromosome 5, B. Chromosome 8, C. Chromosome 13, D. Chromosome 16
C: Chromosome 13
Answer: C: Chromosome 13 
Explanation: c. Chromosome 13(Ref: Nelson's 20/e p 2476-2478, Ghai 8/e 614-615)Retinoblastoma (RB) geneIt is located on chr 13q14; its mutation or deletion is responsible for hereditary form of RetinoblastomaIt encodes the retinoblastoma protein, a tumor suppressor protein that controls cell-cycle phase transition and has roles in apoptosis and cell differentiation