This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Anatomy
Maintenance dose rate of drug depends primarily on 
Select and explain. 
A. Volume of distrubtion, B. Half life, C. Lipid solubility, D. Total body clearance
D: Total body clearance
Answer: D: Total body clearance 
Explanation: Ref-KDT 6/e p34 Maintenance dose is determined by clearance Maintenance dose=CLxPlasma concentration required