This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Pathology
which of the following is hallmak of CHRONIC INFLAMMATION ? 
Select and explain. 
A. tissue destruction, B. mononuclear infiltration, C. wound healing and repair, D. all of the above
A: tissue destruction
Answer: A: tissue destruction 
Explanation: Chronic Inflammation Definition: * Inflammation of prolonged duration in which active inflammation, tissue injury and the healing proceed simultaneously * Causes: * Persistent Infections * Ex. Treponema palladium (causative organism of syphilis) * Organism of low toxicity and evoke an immune reaction = delayed hypersensitivity * Prolonged Exposure to toxic Agents * Autoimmunity * Ex. Autoimmune diseases . ref : robbins 10th ed