This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Not true about Fosphenytoin is? 
Select and explain. 
A. Used for GTCS, B. Prodrug of phenytoin, C. Lipid soluble, D. Highly protein bound
C: Lipid soluble
Answer: C: Lipid soluble 
Explanation: Ans. is 'c' i.e., Lipid soluble o Fosphenytoin is water soluble prodrug of phenytoin has been introduced to overcome the difficulites in iv adminstration of pheytoin in status epilepticus. o Fosphenytoin is cleaved into phenytoin by nonspecific phsophatases in red blood cells, liver and other tissues. o Fosphenytoin has high plasma protein binding and it displaces phenytoin from plasma proteins, resulting in increased free phenytoin concentrations until the conversion of fosphenytoin to phenytoin is complete. o On iv injection, fosphenytoin is less damaging to vascular intima, therefore can be injected at a faster rate. o While phenytoin cannot be injected in a drip of glucose solution, fosphenytoin can be inected with both saline and glucose. o Fosphenytoin is useful for adults with paial or generalized seizures when intravenous or intramuscular administration is indicated