This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carcinoma Cervix, Subject name: Gynaecology & Obstetrics
Pap smear of Lelawati 45-years female shows CIN grade III. Which of the following is the next step in management: 
Select and explain. 
A. Punch biopsy, B. Large loop excision, C. Colposcopy directed biopsy, D. Cone biopsy
C: Colposcopy directed biopsy
Answer: C: Colposcopy directed biopsy 
Explanation: Ans. is c, i.e. Colposcopy directed biopsyRef: CGDT 10th/ed, p837, 841; Harrison 17th/ed, p608; Williams Gynecology 1st/ed, p628, Table 29-6 William Gynae 3rd/ed, p629