This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Mechanism of action trimetazidine is ? 
Select and explain. 
A. Fatty acid synthase inhibitor, B. Na channel inhibitor, C. K channel opener, D. Inhibiting mitochondrial LC3-KAT
D: Inhibiting mitochondrial LC3-KAT
Answer: D: Inhibiting mitochondrial LC3-KAT 
Explanation: Ans. is'd'i.e.,Inhibiting mitochondrial LC3-KAT(Ref: KDTh/e p. 554)Trimetazidine:This antianginal drug acts by non hemodynamic mechanisms.The mechanism of action of trimetazidine is unceain, but it may improve cellular tolerance to ischaemia by inhibiting mitochondrial long chain 3-ketoacyl-CoAthiolase (LC3-KAT) a key enzyme in fatty acid oxidation- thereby reducing fatty acid metabolism and increasing glucose metabolism in myocardium.