This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Thalamus, Hypothalamus and Basal Ganglia, Subject name: Physiology
Pyrogens act on which site of brain - 
Select and explain. 
A. Basal ganglia, B. Limbic system, C. Thalamus, D. Hypothalamus
D: Hypothalamus
Answer: D: Hypothalamus 
Explanation: Ans. is 'd' i.e., Hypothalamus Pyrogeneso Pyrogenes are substances that cause fever,o Pyrogens may be exogenous or endogenousExogenous - Bacterial toxinsEndogenous - IL-1, TNF-a, IL-6, Interferons, Ciliory's neurotropic factoro These pyrogenes increase the level of PGE, in the hypothalamus that elevates the thermoregulatory' set point and causes fever.