This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Pharmacology
Mechanism of action of metoclopramide: 
Select and explain. 
A. Increase the lower esophageal sphincter, B. Decrease the acid secretion, C. Increase gastric peristalsis, D. Ulcer healing agent
A: Increase the lower esophageal sphincter
Answer: A: Increase the lower esophageal sphincter 
Explanation: Ans. A. Increase the lower esophageal sphincterMetoclopramide is prokinetic drug. It acts on D2 and 5Ht3 receptor. There is increase in acetylcholine level and there is increase in LES and gastric motility.