This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Gram-Positive Infections - Corynebacterial Infections, Subject name: Physiology
The protein that anchors both actin and titin at Z lines is? 
Select and explain. 
A. Myomesin, B. Nebulin, C. a-actinin, D. Myosin
C: a-actinin
Answer: C: a-actinin 
Explanation: Ans. (c) a-actinin(Ref: Gautel et al. Journal of Experimental Biology (2016) 219, 135-145)a-Actinin anchors both titin and actin filaments at Z linesMyomesin and obscurin are the myosin cross linking protein that attaches myosin at M lineNebulin is an acting binding protein that regulates the length of thin filaments