This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Intracanalicular hepatic apparatus is affected by-a) Alagille syndromeb) Cystic fibrosisc) Congential hepatic fibrosisd) Caroli diseasee) Polycystic liver disease 
Select and explain. 
A. bcde, B. abd, C. abcd, D. acde
A: bcde
Answer: A: bcde 
Explanation: A heterogenous group of lesions causing altered architechture of intrahepatic billiary tree. They are :
	Von Meyenburg complexes  
	Congenital hepatic fibrosis
	Polycystic liver disease
	Caroli disease
Alagille syndrome is absence of portal tract, bile duct peculiar facies, vertebral anomalies and CVS defects.
In cystic fibrosis — bile canaliculi are plugged by mucinous material when longstanding, can cause biliary cirrhosis. It cause ductular proliferation and portal inflammation.