This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Irreversible cell Injury/Necrosis, Subject name: Pathology
CAR-T cells are used in the treatment of which of the following cancers? 
Select and explain. 
A. Acute lymphoblastic leukemia, B. Soft tissue sarcoma, C. Medulloblastoma, D. Small cell lung carcinoma
A: Acute lymphoblastic leukemia
Answer: A: Acute lymphoblastic leukemia 
Explanation: CAR-T cells Chimeric antigen receptor (CAR) T cells are T-cells extracted from patient and modified in vitro to change T-cell receptor to detect specific protein on surface of malignant cells such as CD19 Currently approved for use in acute lymphoblastic leukemia and B-cell NHLs Examples of CAR-T cells are Kymria (ALL), Yescaa (DLBCL)