This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney and ureter, Subject name: Surgery
The most impoant determinant of prognosis in Wilm's tumor: 
Select and explain. 
A. Stage of disease, B. Loss of heterozygosity of chromosome 1p, C. Histology, D. Age less than one year at presentation
C: Histology
Answer: C: Histology 
Explanation: Most impoant prognostic factor in most of malignancies- Stage (TNM) Exception- Wilms tumor and soft tissue sarcoma In Wilms tumor, Most impoant Prognostic Factor- Histology > Stage In soft tissue sarcoma, most impoant prognostic factor - Tumor grade