This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Ram Prashad is admitted to Guru Teg Bahadur Hospital with respiratory infection for which antibiotic tobramycin is ordered. The clearance and Vd of tobramycin in him are 160 ml/min and 40 L, respectively. If you wish to give Ram Prashad an intravenous loading dose to achieve the therapeutic plasma concentration of 4 mg/L rapidly, how much should be given? 
Select and explain. 
A. 0.1 mg, B. 10 mg, C. 115.2 mg, D. 160 mg
D: 160 mg
Answer: D: 160 mg 
Explanation: Loading dose = Vd x target plasma cone.
= 40 L x 4 mg/L
= 160 mg
Clearance plays no role in the determination of loading dose. It is given to confuse you.