This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: miscellaneous, Subject name: Pathology
Siuin is associated with ? 
Select and explain. 
A. Cancer, B. Diabetes, C. Ageing, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: Calorie restriction prolongs lifespan and this longevity appears to be mediated by a family of proteins known as siuin.They have histone deacetylase activity.Red wine can activate siuins and thus increase lifespan. Actions of siuins:- Siuins promote the expression of many genes which increase longevity. The proteins products of these genes increase metabolic activity, reduce apoptosis, stimulate protein folding and inhibit the damaging effects of oxygen-free radicals. Siuins also increase insulin sensitivity and glucose metabolism.