This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Enzyme Kinetics, Subject name: Biochemistry
Non-competitive enzyme inhibition leads to: (PGI Nov 2010) 
Select and explain. 
A. Vmax|, B. Vmax|, C. Vmax unchanged, D. Km|
B: Vmax|
Answer: B: Vmax| 
Explanation: Ans: B (Vmax|) Non-Competitive inhibition The inhibitor reacts with an adjacent site and not with the catalytic site, but alters the enzyme in such a way that it loses its catalytic property. Thus Km is unchanged but Vmax is reduced? If the inhibitor can be removed from its site of binding without affecting the activity of the enzyme, it is called as Reversible -Non competitive inhibitionQ