This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following tumors show increased -kit - 
Select and explain. 
A. Yolk sac tumor, B. Embryonal carcinoma, C. Choriocarcinoma, D. Seminoma
D: Seminoma
Answer: D: Seminoma 
Explanation: Ans. is 'd' i.e., Seminoma o C KIT or CDII 7 is a proto-oncogene, overexpression or mutations of this protein can lead to cancer. o Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism.