This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
In Testicular Feminization syndrome Gonadectomy is indicated : 
Select and explain. 
A. As soon as it is diagnosed, B. At pubey, C. Only when Malignancy develops in it, D. When hirsutism is evident
B: At pubey
Answer: B: At pubey 
Explanation: At pubey Patients of Testicular Feminization syndrome (Androgen insensitivity) are genotypically males (Karyotype 46XY) but phenotypically females (i.e. male pseudo hermaphroditism). Due to the presence of Y chromosome gonads are testis which remain intraabdominal and have a malignant potential (Most common = Gonadoblastoma, Dysgerminoma). Therefore testis should be removed in such patients. B/L Laparoscopic Gonadectomy is the preferred proceduredeg. As far as timing of Gonadectomy is concerned ? "In patient with complete androgen insensitivity, the testis should be removed 'ter Pubeal developmen is complete to prevent malignant degeneration.