This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Disorders of Amino acid Metabolism, Subject name: Pediatrics
Biotin may be used for treatment of which of the following conditions? 
Select and explain. 
A. Maple syrup urine disease, B. Methylmalonic acidemia, C. Phenylketonuria, D. Multiple carboxylase deficiency
D: Multiple carboxylase deficiency
Answer: D: Multiple carboxylase deficiency 
Explanation: Biotin is a cofactor for carboxylase, so it can be used in the treatment of multiple carboxylase deficiency. Maple syrup urine disease- Thiamine Methylmalonic acidemia- Vitamin B12, L- carnitine, Metronidazole Phenylketonuria- Tetrahydrobiopterin