This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Cardiovascular system, Subject name: Pharmacology
Nitroglycerine causes all except 
Select and explain. 
A. Hypotension and bradycardia, B. Methemoglobinemia, C. Hypotension and tachycardia, D. Vasodilation
A: Hypotension and bradycardia
Answer: A: Hypotension and bradycardia 
Explanation: Methemoglobinemia is not marked in clinically used doses. Nitrates produce some aeriolar dilatation and slightly decrease total peripheral resistance (TPR) or afterload on hea. With usual doses, and if the patient does not stand still (which ors pooling of blood in the legs), tachycardia is not prominent. With large doses and if the mean BP falls significantly, reflex sympathetic stimulation occurs ie tachycardia, increased cardiac contractility leading to increased cardiac work. Ref: Tripathi 8th ed. (REF. ESSENTIALS OF MEDICAL PHARMACOLOGY K.D TRIPATHI-6th edition Page No.523)