This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Amplification of N-Myc is associated with which a tumor? 
Select and explain. 
A. Neuroblastoma, B. Retinoblastoma, C. Osteosarcoma, D. Neuroma
A: Neuroblastoma
Answer: A: Neuroblastoma 
Explanation: Amplification of N-Myc is associated with a variety of tumors, most notably neuroblastomas.
This gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.