This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NEET Jan 2020, Subject name: Pathology
Loss of foot processes seen on electron microscopy of renal biopsy is a classical feature in which of the following? 
Select and explain. 
A. Membranous nephropathy, B. Minimal change disease, C. lgA nephropathy, D. Rapidly progressive gloerulonephritis
B: Minimal change disease
Answer: B: Minimal change disease 
Explanation: IgA nephropathy - Mesangial IgA deposits RPGN - Findings depend on the type of RPGN and cause. Membranous nephropathy - Subepithelial deposits (Spike and dome appearance) Minimal change disease (MCD): Effacement of foot processes of podocytes and damage to podocytes seen on electron microscopy Most common cause of nephrotic syndrome in children is MCD and in adults, it is FSGS.