This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Haematology, Subject name: Medicine
Which disorder is most likely associated with erythroid hyperplasia in the bone marrow? 
Select and explain. 
A. Anemia of chronic disease, B. Thalassemia minor, C. 7 to 10 days after a GI bleed, D. Iron deficiency
C: 7 to 10 days after a GI bleed
Answer: C: 7 to 10 days after a GI bleed 
Explanation: Erythroid hyperplasia in the bone marrow is a response of the erythroid series to erythropoietin stimulation. These stimuli include hypoxemia (e.g., chronic, obstructive pulmonary disease), anemia less than 7 gm/ dl, a left-shifted oxygen dissociation curve (e.g., carbon monoxide poisoning), a bleed more than 5 to 7 days, and testosterone. Anemia of chronic disease, thalassemia minor, and iron deficiency have problems in hemoglobin synthesis, so these would not be expected to have a reticulocyte response. In chronic renal disease, there is a decreased concentration of erythropoietin, which results in a normocytic anemia and no reticulocyte response. Ref - Harrison's internal medicine 20e pg 391, 391f, 684, 696