This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Radiology
Which one of the following is the earliest radiographic manifestation of childhood leukemia? 
Select and explain. 
A. Radiolucent transverse metaphyseal band, B. Diffuse demineralization of bones, C. Osteoblastic lesions in skull, D. Parenchymal pulmonary lesions on chest films
A: Radiolucent transverse metaphyseal band
Answer: A: Radiolucent transverse metaphyseal band 
Explanation: Metaphyseal translucencies are the earliest and most characteristic features of childhood leukemia