This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
The sign or symptom most suggestive of metastatic disease is: 
Select and explain. 
A. Paraesthesia, B. Sudden swelling, C. Root resorption, D. Diffuse radiolucency
A: Paraesthesia
Answer: A: Paraesthesia 
Explanation: None