This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
Which of the following adverse effects is most likely to occur with sulfonamides? 
Select and explain. 
A. Neurologic effects including headache, dizziness, and lethaargy, B. Hematuria, C. Fanconi's anemia, D. Skin reactions
D: Skin reactions
Answer: D: Skin reactions 
Explanation: (Ref: KDT 6/e p684) Rash is the most common adverse effect seen with the use of sulfonamides.