This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Mucopolysacchidosis, which is a lysosomal storage disease, occurs due to abnormality in: 
Select and explain. 
A. Hydrolase enzyme, B. Dehydorgenase enzyme, C. Lipase enzyme, D. Phosphatase
A: Hydrolase enzyme
Answer: A: Hydrolase enzyme 
Explanation: Ans: a. Hydrolase enzyme [Ref Harper 30th/638-39, 29th/589, 599, 600; Lippincott 6th/163-64JThe mucopolysaccharidoses are hereditary diseases caused by a deficiency of any one of the lysosomal hydrolases normally involved in the degradation of heparan sulfate and/or dermatan sulfateThey are progressive disorders characterized by accumulation of glycosaminoglycans in various tissues, causing a range of symptoms, such as skeletal and extracellular matrix deformities, and mental retardation.Children who are homozygous for any one of these diseases are apparently normal at bih, then gradually deteriorate. In severe cases, death occurs in childhood.Diagnosis is confirmed by measuring the patient's cellular level of the lysosomal hydrolases. Bone marrow and cord blood transplants have been used to treat Hurler and Hunter syndrome