This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Pharmacology
Which diuretic acts without requiring access to renal tubular lumen 
Select and explain. 
A. Thiazide, B. Carbonic anhydrase inhibitors, C. Aldosterone antagonists, D. Loop diuretics
C: Aldosterone antagonists
Answer: C: Aldosterone antagonists 
Explanation: Mechanism of action of diuretics: Aldosterone antagonists: Aldosterone acts by combining with an intracellular mineralocoicoid receptor It induces the formation of aldosterone-induced proteins (AIP) . These AIPs promote Na+ reabsorption and K+ secretion Spironolactone is an aldosterone antagonist It acts from the interstitial side of the tubular cell It combines with Mineralocoicoid Receptor and inhibits the formation of AIPs