This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Systemic Bacteriology Pa 1 (Gram Positive Cocci, Gram Negative Cocci), Subject name: Microbiology
Neisserial infection are associated with: 
Select and explain. 
A. Deficiency of early complements, B. Deficiency of late complements, C. There is not such association, D. Any deficiency can be associated
B: Deficiency of late complements
Answer: B: Deficiency of late complements 
Explanation: Option 1 C1-C4 (early complements) deficiencies - SLE, glomerulonephritis ,pyogenic infections Option 2 Deficiency of C5- C9 (Membrane attack complex)( late components) of the complement -- show increased susceptibility to meningococcal disease.