This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which finding on electron microscopy indicates irreversible cell injury- 
Select and explain. 
A. Dilatation of endoplasmic reticulum, B. Dissociation of ribosomes from rough endoplasmic reticulum, C. Flocculent amorphous densities in the mitochondria, D. Myelin figures
C: Flocculent amorphous densities in the mitochondria
Answer: C: Flocculent amorphous densities in the mitochondria 
Explanation: Ans. is 'c' i.e., Flocculent densities in mitochondria Mechanism of irreversible cell injury :? Membrane damage is the central factor in the pathogensis of irreversible cell injury. Note : o Earliest change of reversible cell injury is cellular swelling. o Myelin figures (laminated structure) derived from damaged membrane of organelles and plasma membrane, first appear during reversible injury, but become more pronounced in irreversible injury.