This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
All of the following are contraindications for breast conserving surgery except 
Select and explain. 
A. Tumours more than 4cm in size, B. Multicentricity, C. Centrally located tumour, D. Prior neoadjuvant chemotherapy
D: Prior neoadjuvant chemotherapy
Answer: D: Prior neoadjuvant chemotherapy 
Explanation: Answer- D. Prior neoadjuvant chemotherapyInvolves resection of the primary breast cancer with a margin of normal-appearing breast tissue, adjuvant radiation therapy with or without assessment of axillary lymph node status.