This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Not a specific tumor marker is - 
Select and explain. 
A. CD 99, B. HMB 45, C. b- globulin, D. CEA
D: CEA
Answer: D: CEA 
Explanation: Ans is 'd' i.e., CEA Carcinoembryonic antigen (CEA) is used as tumor marker for colorectal cancer (major use), lung cancer, breast cancer and ovarian cancer.It is alsoincreased in non-neoplastic conditions like alcoholic cirrhosis, hepatitis, IBD (CD, UC), smoking and pancreatitis.CEA lacks sensitivity as well as specificity, hence cannot be used to confirm the diagnosis.About other optionsCD 99 - specific marker for Ewing's sarcomaHMB 45 - specific marker for malignant melanomab - globulin - specific marker for multiple myeloma