This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neuro-Ophthalmology, Subject name: Ophthalmology
Leber's amourotic optic neuropathy inheritance is 
Select and explain. 
A. Mutation in mitochondrial DNA, B. Autosomal Dominant, C. X-linked recessive, D. Autosomal Recessive
A: Mutation in mitochondrial DNA
Answer: A: Mutation in mitochondrial DNA 
Explanation: Ans. a. Mutation in mitochondrial DNALeber hereditary optic neuropathy (LHON) is rare ganglion cell degeneration.Papillomacular bundle is particularly affected in this case.The condition is caused by maternally inherited mitochondrial DNA point mutations, most frequently (50-90%) at nucleotide position 1178 (G to A) in theMT-ND4 gene.Most commonly affects age group 15-35 years.