This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Hepatitis, Subject name: Medicine
Acute Hepatitis B infection is diagnosed by? 
Select and explain. 
A. HbsAg, B. HbcAg, C. HbsAg + IgM anti-HBc antibody, D. HbsAg + HbcAg
C: HbsAg + IgM anti-HBc antibody
Answer: C: HbsAg + IgM anti-HBc antibody 
Explanation: HBsAg Anti-HBs Anti-HBcAg HBeAg Acute hepatitis B, High infectivity + - IgM + Window period - - IgM - Chronic Hepatitis B + - IgG + Cured - + IgG - Vaccination - + - -