This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
For pain control in a patient having history of G I bleeding, which of the following is given? 
Select and explain. 
A. Nimesulide, B. Ibuprofen, C. Rofecoxib, D. Pentazocin
C: Rofecoxib
Answer: C: Rofecoxib 
Explanation: SELECTIVE COX-2 INHIBITORS- Rofecoxib,etoricoxib,celecoxib They cause little gastric mucosal damage; the occurrence of peptic ulcer and ulcer bleeds is clearly lower than with traditional NSAIDs. They do not depress TXA2 Production by platelets (COX-I dependent); do not inhibit platelet aggregation or prolong bleeding time but reduce PGI2 production by vascular endothelium. They increase the risk of cardiovascular events ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION;KD TRIPATHI;PAGE NO 205