This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology, Subject name: Pharmacology
Which of the following is serious adverse effects seen with Zoledronate 
Select and explain. 
A. Acute renal failure, B. Ventricular fibrillation, C. Peptic ulcer, D. Anterior uveitis
A: Acute renal failure
Answer: A: Acute renal failure 
Explanation: Refer Goodman Gilman 12/e p 1296 The serious adverse effects noted with most of bisphoshonates is osteonecrosis of jaw bone Zoledronate can cause serious side effects as Nephrotoxicity and renal failure