This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Medicine
In essential lhypeension the drug prescribed with least cardiovascular effect 
Select and explain. 
A. Clonidine, B. Alpha blocker, C. Beta blocker, D. ACE inhibitor
D: ACE inhibitor
Answer: D: ACE inhibitor 
Explanation: Aldosterone Antagonists Spironolactone is a nonselective aldosterone antagonist that may be used alone or in combination with a thiazide diuretic. It may be a paicularly effective agent in patients with low-renin essential hypeension, resistant hypeension, and primary aldosteronism. ref:Harrison&;s principles of internal medicine,ed 18,pg no 3079