This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nephrotic Syndrome, Subject name: Pathology
Steroid resistant nephrotic syndrome associated with which gene? 
Select and explain. 
A. NPHS 2, B. HOX II, C. PAX, D. ACE
A: NPHS 2
Answer: A: NPHS 2 
Explanation: 2 patterns of autosomal recessive FSGS Steroid-resistant nephrotic syndrome Congenital nephrotic syndrome NPHS 2 gene mutation NPHS 1 mutation Maps to chromosome 1q25-q31 Maps to chromosome 19q13 Encodes the protein podocin Encodes the protein nephrin