This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
BRAF V600E mutationsare seen in all of the following except 
Select and explain. 
A. Langherhan’s cell histiocytosis, B. Erdheim Chester disease, C. Ovarian carcinoma, D. Grade II astrocytoma
D: Grade II astrocytoma
Answer: D: Grade II astrocytoma 
Explanation: BRAF V600E (valine converting to glutamate at 600thposition)is seen in the following cancers

Langerhan’s cell histiocytosis
Hairy cell leukemia
Malignant melanoma
Pilocytic astrocytoma (WHO Grade I astrocytoma)
Ovarian carcinoma
Endometrial carcinoma
Colorectal carcinoma
Papillary carcinoma thyroid
Erdheim Chester disease