This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Small Intestine Malabsorption disorders, Subject name: Pathology
Which of the following is a histological feature of Whipple's disease? 
Select and explain. 
A. Infiltration of histiocytes in the lamina propria, B. Granuloma in the lamina, C. Macrophages with PAS (+) material inside the lamina propria, D. Eosinophils in the lamina propria
C: Macrophages with PAS (+) material inside the lamina propria
Answer: C: Macrophages with PAS (+) material inside the lamina propria 
Explanation: Whipple's disease Hallmark - Presence of PAS +ve, diastase resistant granules inside foamy macrophages containing rod shaped bacilli. The presence of T. Whipplei outside macrophages is more impoant indicator of active disease than their presence inside the macrophages. Multisystem involvement: Joints (Early involvement) Intestine - Impaired lymphatic drainage resulting in malabsorption & diarrhea Lymph nodes CNS (Late involvement) Rx - Antibiotics