This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Childhood Tumors, Subject name: Pediatrics
ADAMTS-13 is a metalloproteinase. It is produced by the: 
Select and explain. 
A. Alfa cells of the pancreas, B. Oligodendrocyte in the brain, C. Stellate cells in the liver, D. Tubular epithelial cells of the kidney
C: Stellate cells in the liver
Answer: C: Stellate cells in the liver 
Explanation: Ans. C. Stellate cells in the liverADAMTS-13 is a metalloproteinase which is produced by the stellate cells of the liver. It cleaves von Willebrand factor. Therefore, when ADAMTS-13 deficiency occurs, large multimer of VWF attach to platelets and cause microcirculatory failure.