This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Anatomy
The Investigation of choice in a 55-year-old postmenopausal women who has presented with postmenopausal bleeding is: 
Select and explain. 
A. Pap smear, B. Fractional curettage, C. Transvaginal ultrasound, D. CA-125 estimation
B: Fractional curettage
Answer: B: Fractional curettage 
Explanation: Common causes of postmenopausal bleeding Genital malignancy (Me) Decubitus ulcer DUB. Urethral caruncle. Senile endometritis DIAGNOSIS Speculum Examination If a growth is found, punch biopsy is to be taken. If no growth is visible and the cervix looks apparently healthy- Cervical smear Aspiration cytology Fractional curettage, if the cervical cytology becomes negative. Hysteroscopic evaluation and directed biopsy Laparoscopy in suspected cases of ovarian or adnexal mass. Detection of a benign lesion should not prevent fuher detailed investigations to rule out malignancy.