This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Miscellaneous, Subject name: Pathology
Which of the following is not associated with actions of siuins? 
Select and explain. 
A. Inhibit metabolic activity, B. Reduce apoptosis, C. Increased insulin sensitivity, D. Reduced by calorie restriction
D: Reduced by calorie restriction
Answer: D: Reduced by calorie restriction 
Explanation: Siuins They are a family of NAD-dependent protein deacetylases. There are at least 7 types They have non-redundant functions designed to adapt bodily functions to various environmental stresses, including Food deprivation and DNA damage. Functions:- These include proteins that inhibit metabolic activity Reduce apoptosis Stimulate protein folding Inhibit the harmful effects of oxygen free radicals. Siuins also increase insulin sensitivity and glucose metabolism, and may be targets for the treatment of diabetes.