This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Biochemistry
Sickling in 'HbS' disease is primarily caused by 
Select and explain. 
A. Decreased Solubility, B. Decreased Stability, C. Altered function, D. Altered 02 binding capacity
A: Decreased Solubility
Answer: A: Decreased Solubility 
Explanation: A i.e. Decreased Solubility