This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Sister Mary Joseph nodule is most commonly seen with: March 2011 
Select and explain. 
A. Ovarian cancer, B. Stomach cancer, C. Colon cancer, D. Pancreatic cancer
B: Stomach cancer
Answer: B: Stomach cancer 
Explanation: Ans. B: Stomach cancer Gastric tumour may spread the abdominal cavity to the umbilicus (Sister Joseph's nodule) Sister May Joseph's nodule: Periumbilical nodule/ hard mass Represents metastatin involvement of the paraumbilical nodes from intrapelvic or intraabdominal malignancies Seen with: - Stomach - Large bowel - Ovary - Pancreatic tumour Indicates poor prognosis