This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Acantholysis, resulting from desmosome weakening by autoantibodies directed against the protein desmoglein, is the disease mechanism attributed to which of the following? 
Select and explain. 
A. Epidermolysis bullosa, B. Mucous membrane pemphigoid, C. Pemphigus vulgaris, D. Herpes simplex infections
C: Pemphigus vulgaris
Answer: C: Pemphigus vulgaris 
Explanation: In pemphigus vulgaris, autoantibodies attach to antigens (desmoglein) found in desmosomes that keep keratinocytes linked to each other. Cells eventually separate from each other (acantholysis), resulting in short-lived intraepithelial vesicles/bullae.