This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
Irreversible cell injury shows 
Select and explain. 
A. Large flocculent mitochondrial densities, B. Cellular swelling, C. Plasma membrane blebbing, D. Loss of microvilli
A: Large flocculent mitochondrial densities
Answer: A: Large flocculent mitochondrial densities 
Explanation: Reversible cell injury: Cellular swelling, fatty change, plasma membrane blebbing and loss of microvilli, mitochondrial swelling, dilation of the ER, eosinophilia (due to decreased cytoplasmic RNA)Features of irreversible cell injury are Cell membrane damage, Large flocculent, mitochondrial densities, Myelin figures, Nuclear changes: pyknosis, karyorrhexis, karyolysisRobbins 9th edition p.45-47