This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Histaminics, Subject name: Pharmacology
About cetirizine all are true except- 
Select and explain. 
A. It is a 2nd generation anti histaminic, B. It is a metabolite of hydroxyzine, C. Good CNS penetration, D. Inhibits release of histamine
C: Good CNS penetration
Answer: C: Good CNS penetration 
Explanation: Ans. is 'c' i.e., Good CNS penetration Cetrizine* Cetrizine is a 2nd generation anti histaminic* It is a metabolite of hydroxyzine with marked affinity for the peripheral H1 receptors,* It penetrates CNS poorly and has mild sedating effect.* It inhibits release of histamine from mast cells and therefore has been used for urticarial and atopic dermatitis.* It is non - arrhythmogenic.