This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Which of the following is not true regarding Medullary Ca thyroid? 
Select and explain. 
A. Hereditary, B. Secrets calcitonin, C. Hormone dependant, D. Amyloid stroma
C: Hormone dependant
Answer: C: Hormone dependant 
Explanation: Medullary thyroid cancer (MTC) originates from the parafollicular cells (C cells), which produce the hormone calcitonin. Approximately 25% of medullary thyroid cancer is genetic in nature, caused by a mutation in the RET proto-oncogene. When it coexists with tumors of the parathyroid gland and medullary component of the adrenal glands (pheochromocytoma) it is called multiple endocrine neoplasia type 2 (MEN2). The majority of C cells are located at the junction of the upper third and lower two thirds of the thyroid gland; hence, this is the most common location of MTC. On FNAC, MTC is characterized by the presence of stromal amyloid and the absence of thyroid follicles.