This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Unknown
Use of valproate during pregnancy may result in: 
Select and explain. 
A. Mental retardation, B. Respiratory depression, C. Hydantoin syndrome, D. Neural tube defect
D: Neural tube defect
Answer: D: Neural tube defect 
Explanation: Valproate crosses the placenta and has been reported to have caused teratogenic effects, including neural tube defects (anencephaly, meningomyelocele, and spina bifida) in the fetus when the mother received valproate during the first trimester of pregnancy.