This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulators, Subject name: Pharmacology
TNF -alpha inhibitors should not be used in: 
Select and explain. 
A. Rheumatoid ahritis with HIV infection, B. Rheumatoid ahritis with hepatitis B, C. Rheumatoid ahritis with hepatitis C, D. Rheumatoid ahritis with pulmonary fibrosis
B: Rheumatoid ahritis with hepatitis B
Answer: B: Rheumatoid ahritis with hepatitis B 
Explanation: Tumor necrosis factor-a (TNF-a) inhibitors are known to increase reactivation of concurrent chronic hepatitis B,Hence not used ESSENTIALS OF MEDICAL PHARMACOLOGY: SEVENTH EDITION K.D TRIPATHI PAGE:804,805,884