This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast Cancer - Treatments, Subject name: Surgery
Conservative surgery is not done in breast carcinoma if there is? 
Select and explain. 
A. Lymph node metastasis, B. Sub-areolar lump, C. Lump of size 4 cms, D. Disease involving the lower quadrant only
B: Sub-areolar lump
Answer: B: Sub-areolar lump 
Explanation: ANSWER: (B) sub-areolar lumpREF: Harrison s principles of internal medicine 17th ed chapter 86Breast-conserving surgery is not suitable for all patients: it is not generally suitable for tumor> 5 cm (or for smaller tumors if the breast is small)For tumors invoking the nipple areola complex.For tumors with extensive intraductal disease involving multiple quadrants of the breastFor women with a history of collagen-vascular disease.Do not have convenient access to radiation therapy.Women who either do not have the motivation for breast conservation