This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which one of the following diseases characteristically causes a fatty change in liver? 
Select and explain. 
A. Hepatitis B virus infection, B. Wilson's disease, C. Hepatitis C virus infection, D. Chronic alcoholism
D: Chronic alcoholism
Answer: D: Chronic alcoholism 
Explanation: Alcoholic liver disease (ALIT) is the most frequent secondary fatty liver disease. The secondary fatty liver can also occur in chronic Viral hepatitis C (HCV), chronic viral hepatitis, chronic autoimmune hepatitis (AIH), and Wilson's disease' 
Thus although fatty liver may be seen secondary to all options mentioned in the question chronic alcoholism being the most common cause is the single best answer here.
Following information have been added in 8th/e of Robbins  Non alcoholic fatty liver disease (NAFLD)
It has become the most common cause of chronic liver disease in united states NAFLD includes:

Simple hepatic steatosis → Stable conditions
Steatosis with inflammation → Stable conditions
Non-alcoholic steatohepatitis (NASH) → Can progress to cirrhosis

NAFLD is the most common cause of cryptogenic cirrhosis (cirrhosis of unknown origin).