This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Physiology
Trans-placental spread is least associated with 
Select and explain. 
A. HBV, B. Rubella, C. HSV, D. HIV
B: Rubella
Answer: B: Rubella 
Explanation: HSV is usually transmitted during delivery through an infected maternal genital tract. Transplacental transmission of virus and hospital-acquired spread from one neonate to another by hospital personnel or family may account for some cases. Ref ganong's review of medical physiology 25e 976