This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2019, Subject name: Anaesthesia
On repeated use, which of the following inhalational anaesthetic agent can cause hepatitis: 
Select and explain. 
A. Isoflurane, B. Halothane, C. Sevoflurane, D. Ether
B: Halothane
Answer: B: Halothane 
Explanation: Halothane causes auto immune hepatitis Halothane produces byproduct during metabolism which causes autoimmune hepatitis Auto immune hepatitis d/t repeated use of halothane, preexisting liver dysfunction More seen in female patients, obese patients & middle age patients