This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All of the following are true about Irinotecan except 
Select and explain. 
A. It is a Topo-isomerase II inhibitor, B. It is excreted though liver, C. It is used for colorectal cancer, D. It can cause diarrhoea because of cholinergic property
A: It is a Topo-isomerase II inhibitor
Answer: A: It is a Topo-isomerase II inhibitor 
Explanation: Irinotecan & Topotecan are Topoisomerase-I inhibitors.
Etoposide & Teniposide are Topoisomerase-II inhibitors.