This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All of the following statements about Erlotinib are true, except: 
Select and explain. 
A. Tyrosine kinase inhibitor, B. Food decreases its absorption, C. Rashes may occur, D. Used in Non small cell lung carcinoma
B: Food decreases its absorption
Answer: B: Food decreases its absorption 
Explanation: Ans is 'b' i.e. Food decreases its absorption Erlotinib o Erlotinib is a human HER1/EGFR tyrosine kinase inhibitor. o It is indicated for treatment of patients with locally advanced or metastatic non small cell lung cancer. It is also used in carcinoma of pancreas, head & neck cancer, hepatocellular carcinoma and carcinoma of unknown primary. o Erlotinib is about 60% absorbed after oral administration and its bioavailability is substantially increased to almost 100% by food The time to peak concentrations is approximately 4 hours after a dose. The half life of erlotinib is about 36 hours and it is eliminated predominately by CYP450 3 A4. Smoking increases the clearance of erlotinib by 24% which may result in treatment failure. o The most common adverse reaction in patients receiving erlotinib are diarrhea and rash. Other side effects are intersitital lung disease, anorexia, pruritis, conjunctivitis, elevated livers enzymes and bleeding.