This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Diagnosis of Hodgkins disease is based on all of the following, except: 
Select and explain. 
A. Reed- Sternberg cells, B. Reactive cellular background, C. Atypical cells in backgriound, D. CD 30 positivity
C: Atypical cells in backgriound
Answer: C: Atypical cells in backgriound 
Explanation: Answer is C (Atypical cells) Atypical cells may be seen in some variants of Hodgkin's disease but they are not required for the diagnosis of Hodgkin's disease