This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Symptomatic Neonatal CNS involvement is most commonly seen in which group of congenital intrauterine infections? 
Select and explain. 
A. CMV and Toxoplasmosis, B. Rubella and Toxoplasmosis, C. Rubella and HSV, D. CMV and Syphillis
C: Rubella and HSV
Answer: C: Rubella and HSV 
Explanation: CNS involvement is a common feature of "TORCH infection". The newborn is asymptomatic at bih. The baby develops symptoms characteristic of the infection in the late neonatal period. Symptomatic CNS manifestations are most common with herpes and rubella infections. Ref: O P Ghai 6th Edition, Page 165; Vope's Neurology of the born 3rd Edition, Page 675