This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: FMGE 2017, Subject name: Pharmacology
All of the following statements about pralidoxime in organophosphate poisoning are true except:- 
Select and explain. 
A. It is given intravenously, B. It should be staed after 24 hours of poisoning, C. It does not cross blood brain barrier, D. Reactivates the AChE enzyme
B: It should be staed after 24 hours of poisoning
Answer: B: It should be staed after 24 hours of poisoning 
Explanation: Organophoshate poisoning - AchE (inhibit Acetyl cholinestrase enzyme) Atropine is drug of choice for organophosphate poisoning Atropine reverses the symptom by blocking receptors Organophosphate poisoning DRUG OF CHOICE- Atropine | | Pralidoxime | | Reactivate Inhibit Receptors Ache enzyme All the oximes are given Intra venously PAM (Pralidoxime ) - periphery (do not cross blood brain barrier) DAM (Diacetyl monoxime) - both in the brain and outside the brain Oximes should be staed as soon as possible after atropine is given If we take long time enzyme aging may occur (enzyme cannot work)