This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
All of the following are vitamin K dependent coagulation factors except: 
Select and explain. 
A. Factor X, B. Factor VII, C. Factor II, D. Factor VIII
D: Factor VIII
Answer: D: Factor VIII 
Explanation: Clotting factors II, VII, IX and X are vitamin K dependent factors.
Six of the proteins involved in clotting require conversion of a number of glutamic acid residues to γ-carboxyglutamic acid residues before being released into the circulation, and hence all six are vitamin K-dependent. These proteins are factors II (prothrombin), VII, IX, and X, protein C and protein S.
Coumarin derivatives such as dicumarol and warfarin are also effective anticoagulants. They inhibit the action of vitamin K, which is a necessary cofactor for the enzyme that catalyzes the conversion of glutamic acid residues to γ-carboxyglutamic acid residues. 
Reference: Ganong’s Review of Medical Physiology TWENTY - FIFTH  EDITION page no 566,567