This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Infectious disease, Subject name: Pediatrics
Symptomatic neonatal CNS involvement is most commonly seen in Which group of congenital intrauterine infection __________ 
Select and explain. 
A. CMV and toxoplasmosis, B. Rubella and toxoplasmosis, C. Rubella and HSV, D. CMV and syphillis
C: Rubella and HSV
Answer: C: Rubella and HSV 
Explanation: Congenital rubella causes chronic meningitis,parenchymal necrosis and vasculitis with calcification. HSV results in HSV encephalitis which is manifested as fever, headache, nuchal rigidity, nausea, vomiting, generalized seizures, and alteration of consciousness. Reference: Nelson textbook of pediatrics 21 st edition Page 1100