This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Drugs in Pregnancy, Subject name: Gynaecology & Obstetrics
Which of the following congential anomalies is seen with maternal use of cocaine 
Select and explain. 
A. Sacral agenesis, B. Hydrops, C. Cleft palate, D. Hyperichosis
C: Cleft palate
Answer: C: Cleft palate 
Explanation: Most adverse outcomes associated with cocaine result from its vasoconstrictive and hypeensive effects. Maternal complications cerebrovascular hemorrhage myocardial damage placental abruption preterm labour, PPROM, precipitous labour Fetal complications cleft palate cardiovascular abnormalities urinary tract abnormalities Skull defects Visceral Infarcts fetal-growth restriction preterm delivery. Children exposed as fetuses are at increased risk for behavioral abnormalities and cognitive impairments.