This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Carbohydrates, Subject name: Biochemistry
In the fed state, major fate of glucose-6-phosphate in tissues is: 
Select and explain. 
A. Storage as fructose, B. Storage as glyceraldehyde-3-phosphate, C. Enters HMP shunt via ribulose-5-phosphate, D. Storage as glycogen
D: Storage as glycogen
Answer: D: Storage as glycogen 
Explanation: Ans. D. Stored as Glycogen(Ref: Harper 31/e page 136,137)The uptake of glucose into the liver GLUT 2 is independent of insulin.In the well fed state, the concentration of glucose entering the liver increases, so does the rate of synthesis of glucose-6-phosphateThis is in excess of the liver's requirement for energy-yielding metabolism. So it is used mainly for synthesis of glycogen.In both liver and skeletal muscle, insulin acts to stimulate glycogen synthetase and inhibit glycogen phosphorylase.