This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Extravascular Changes, Subject name: Pathology
Defective phagolysosome is feature of? 
Select and explain. 
A. Chronic Granulomatous Disease, B. Chediak - Higashi - syndrome, C. Ataxia telangiectasia, D. Fanconi Anemia
B: Chediak - Higashi - syndrome
Answer: B: Chediak - Higashi - syndrome 
Explanation: Inherited defects in phagolysosome function. One such disorder is Chediak-Higashi syndrome, Autosomal recessive condition Defective fusion of phagosomes and lysosomes, resulting in defective phagocytes function and susceptibility to infections. The main leukocyte abnormalities are:- Neutropenia Defective degranulation Delayed microbial killing The gene associated with this disorder encodes a large cytosolic protein called LYST, which is believed to regulate lysosomal trafficking.