This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast, Subject name: Pathology
Which of the following is not true in relation to Osteosarcoma? 
Select and explain. 
A. Paget's disease & prior irradiation are factors, B. Rb gene mutation is associated with hereditary variant, C. c-myc gene implicated in the genesis, D. Codman's triangle is the characteristic x-ray finding
C: c-myc gene implicated in the genesis
Answer: C: c-myc gene implicated in the genesis 
Explanation: c-myc gene implicated in the genesis is wrong. Osteosarcomas occur in all age groups, with a second peak occuring in elderly persons, usually in association with other conditions like pagets disease, etc. A triangular shadow on the x-ray film between coex and raised periosteum (codman triangle) is charecteristics of osteosarcomas. RB gene mutations account for 60%to70% cases of these tumors Robbins basic pathology 9th edition page no 776,777