This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology Pa 1 (Immune Response, Antigen-Antibody Reactions, Hypersensitivity, Structure of Immune System, Immunodeficiency Disorders), Subject name: Microbiology
Which of the following statements concerning immunoglobulins is wrong: 
Select and explain. 
A. IgM does not cross placenta, B. IgE increased in parasitic infection, C. IgM increased in primary response, D. Fetal infection can be diagnosed by detection of IgG
D: Fetal infection can be diagnosed by detection of IgG
Answer: D: Fetal infection can be diagnosed by detection of IgG 
Explanation: Only IgG can cross placenta, other classes cannot cross placenta. Hence fetal infection cannot be diagnosed by IgG, IgM is the predominant antibody present in primary immune response. Levels of IgE are markedly raised in parasitic infections.