This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
True about Trastuzumab are all except: 
Select and explain. 
A. Better combination with paclitaxel, B. Used in metastatic breast cancer, C. Causes upregulation of HER2/neu, D. No bone marrow toxicity
C: Causes upregulation of HER2/neu
Answer: C: Causes upregulation of HER2/neu 
Explanation: Causes upregulation of HER2/neu