This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
TRUE about sepsis related acute kidney injury is: 
Select and explain. 
A. AKI seen in 20% cases of severe sepsis, B. Ove hypotension is the cause of decreased GFR, C. Tubular injury is manifested by tubular debris and casts in urine, D. Generalised aerial vasoconstriction is present
C: Tubular injury is manifested by tubular debris and casts in urine
Answer: C: Tubular injury is manifested by tubular debris and casts in urine 
Explanation: AKI complicates more than 50% of cases of severe sepsis. Decreases in GFR with sepsis can occur even in the absence of ove hypotension Tubular injury associated with AKI in sepsis as manifest by the presence of tubular debris and casts in the urine. The hemodynamic effects of sepsis--arising from generalized aerial vasodilation, mediated in pa by cytokines that upregulate the expression of inducible NO synthase in the vasculature can lead to a reduction in GFR. Ref: Harrison-E-18, P-2294.