This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Breast Cancer - Types and Staging, Subject name: Surgery
False about Paget disease of the nipple: 
Select and explain. 
A. Leads to destruction of whole nipple, B. It is an eczematous condition, C. Associated with underlying carcinoma, D. Associated with poor prognosis
B: It is an eczematous condition
Answer: B: It is an eczematous condition 
Explanation: Ans: b (It is an eczematous condition) Ref: Bailey, 24th ed, p. 837Paget's disease of nippleIs a superficial manifestation of an underlying carcinoma(DCIS or invasive ductal carcinoma)It presents as an eczema - like condition of nipple and areola, which persists despite local treatment.Nipple is eroded slowly and eventually disappears (poor prognosis)- Microscopy - Characterised by presence of large, ovoid cells with abundant clear, pale-staining cytoplasm in the Malpighian layer of epidermis.Eczema of nipplePaget disease of nipple- Often bilateral- Unilateral- Is often seen during lactation- Is seen at menopause- Itches- Does not itch- Vesicles present- No vesicles found- Nipple remain intact- Nipple may be destroyed- No lump felt deep to nipple- May feel a lump deep to the nipple