This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neuromuscular Blocker, Subject name: Anaesthesia
Factors responsible for cardiovascular effects of non depolarizing neuromuscular blockers:- 
Select and explain. 
A. Histamine release, B. Effects mediated by autonomic nicotinic cholinergic receptors, C. Pancuronium produced a profound vagolytic response, D. All of the above
D: All of the above
Answer: D: All of the above 
Explanation: All benzylisoquinoline except cisatracurium causes histamine release - | BP | HR - CVS Effects mediated by autonomic nicotinic Cholinergic receptor ex. Pancuronium (vagal blockade) | BP | HR Pancuronium produced a profound vagolytic response characterized by tachycardia, reduction in hea rate variability and baroreflex sensitivity .