This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Kidney, Subject name: Medicine
Which type of collagen defect in Good pasture Syndrome 
Select and explain. 
A. Type I, B. Type II, C. Type III, D. Type IV
D: Type IV
Answer: D: Type IV 
Explanation: (Type IV) (805- CMDT- 08) (2073-H17th)Good Pasture syndrome - is an uncommon auto immune disease characterized by the presence of circulating auto antibodies targeted against the non collagenous domain of the a3 chain of collagen IV* These antibodies initiate an inflammatory destruction of the basement membrane in kidney, glemeruli and lung alveoli, giving rise to proliferative usually RPGN and a necrotizing hemorrhagic interstitial pneumonitisAlport's syndrome - is hereditary nephritis, characterised by diffuse glomerular basement membrane thinning. There is defect in the synthesis of type IV collagen because there is a mutation in the gene encoding a- 5 chain of collagen type IV (Col 4A5) (AIIMS- 06)