This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Cushing's disease is associated with: 
Select and explain. 
A. Increased ACTH and increased coisol, B. Increased urinary Catecholamines, C. Increased ADH, D. Decreased ACTH and increased coisol levels
A: Increased ACTH and increased coisol
Answer: A: Increased ACTH and increased coisol 
Explanation: Answer is A (Increased ACTH and increased Coisol) Cushing's disease refers to increased production of Coisol (T Coisol) by Adrenals secondary to an ACTH producing tumor (1st ACTH) in the pituitary gland. It is thus associated with increased levels of ACTH and Coisol. Only an individual who has (increased coisol due to) an ACTH producing pituitary tumor is defined as having Cushing's disease, whereas Cushing's syndrome refers to all causes of excess coisol' - Harrison Increased urinary catecholamines is a feature of pheochromocvtoma and not Cushing's disease.