This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacodynamics, Subject name: Pharmacology
Loading dose depends on the following factors except: 
Select and explain. 
A. Drug concentration to be achieved, B. Volume of distribution, C. Clearance of the drug, D. Bioavailability of drug
C: Clearance of the drug
Answer: C: Clearance of the drug 
Explanation: * Loading dose= volume of distribution x target plasma concentration/fractional bioavailability. * Maintenance dose= clearance x target plasma concentration/fractional bioavailability. * So the answer is clearance as it determines maintenance dose instead of loading dose.