This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Liver & Biliary Tract, Subject name: Pathology
Which of the following is feature of arsenic toxicity? 
Select and explain. 
A. Cirrhosis of liver, B. Non-cirrhotic portal fibrosis, C. Hepatocellular carcinoma, D. Hepatoma
B: Non-cirrhotic portal fibrosis
Answer: B: Non-cirrhotic portal fibrosis 
Explanation: Ans. b (Non-cirrhotic portal fibrosis)> C. HCC. (Ref. Robbin's pathology, 7th ed., pg 907; Table 18-8)Hepatocellular damageExamplesAngiosarcomaVinyl chlorideNCPFArsenicMicrovesicular fatty changeTetracycline, salicylates yellow phosphorus, ethanolMacro vesicu lar fatty changeEthanol, methotrexate, amiodaroneCentrilobular necrosisBromobenzane, CCI4, acetaminophen, halothane, rifampinDiffuse or massive necrosisHalothane, isoniazid acetaminophen, methyldopa, trinitrotoluene,Amanita phylloides (mushroom) toxinHepatitis, acute and chronicMethyldopa, isoniazide, nitrofurantoin, phenytoin, oxyphenisatinFibrosis-cirrhosisEthanol, methotrexate, amiodarone, most drugs that cause chronic hepatitisGranuloma formationSulfonamides, methyldopa, quinidine, phenylbutazone, hydrala zine, allopurinolCholestasis (with or without hepato cellular injury) contraceptives, organic arsenicalsChlorpromazine, anabolic steroids, erythromycin estolate, oralContraceptives, organic arsenicals