This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which of the following is true regarding viral hepatitis- 
Select and explain. 
A. Raised transaminase level correlates well with hepatic injury, B. Variable elevation of transaminase in prodromal phase., C. HAV infection is diagnosed by IgG estimation, D. Elevation of enzyme is specific for liver injury
B: Variable elevation of transaminase in prodromal phase.
Answer: B: Variable elevation of transaminase in prodromal phase. 
Explanation: Role of Aminotransferases in the diagnosis of Hepatitis.

Serum aminotransferases are sensitive markers of liver cell injury such as occurring in hepatitis but they are not specific for liver injury. They are also present in heart, skeletal muscle, brain.
Serum aminotransferases show a variable increase during the prodromal phase of acute viral hepatitis, however, the acute level of these enzymes does not correlate well with the degree of liver cell damage.
About choice, C Harrison states " The diagnosis of acute hepatitis A is made by demonstrating anti-HAV of the IgM class".
IgG anti-HAV is not used for diagnosis of the acute phase of HAV because its level remains elevated for an indefinite period of time.