This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anatomy of skin, Subject name: Dental
A teenager girl with moderate acne is also complaining of irregular menses. Drug of choice with be- 
Select and explain. 
A. Oral jsotretinon, B. Oral acitretin, C. Oral minocycline, D. Cyproterone acetate
D: Cyproterone acetate
Answer: D: Cyproterone acetate 
Explanation: In Acne with associated endocrinological abnormalities like polycystic ovarian syndrome (PCOS) manifests with obesity, hirsutism, androgenetic alopecia and acne. Oestrogens and antiandrogens(cyproterone acetate, spirono lactone, flutamide) and agents designed to inhibit the endogenous production of androgens by the ovary(oral contraceptives and gonadotropin releasing agonists) or adrenal gland(low dose glucocoicoids ) are used Reference Harrison20th edition pg 1206