This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Microbiology
Which of the following is the mechanism of action of tetanospasmin ? 
Select and explain. 
A. Inhibition of release of GABA and glycine, B. Inhibition of Ach release from synapse, C. Inhibition of protein synthesis, D. Activation of adenylyl cyclase
A: Inhibition of release of GABA and glycine
Answer: A: Inhibition of release of GABA and glycine 
Explanation: Ans. is 'a' i.e., Inhibition of release of GABA and glycine Pathogenicity CL tetani has little invasive propey and is confined to the primary site of lodgment. Tetanus results from the action of the potent exotoxin it produces.