This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Bleeding and Thrombotic Disorders, Subject name: Medicine
Both PT and APTT are prolonged in - 
Select and explain. 
A. Factor II deficiency, B. Thrombocytopenia, C. Factor VII deficiency, D. Heparin therapy
A: Factor II deficiency
Answer: A: Factor II deficiency 
Explanation: Ans. is 'a' i.e., Factor II deficiencyo Prolongation of both PT and A PPT is typically seen in deficiency of involoved in the common pathway, namely factor //, factor V and factor X (and fibrinogen).o Heparin in clinical concentrations is typically associated with isolated prolongation of APTT while PT is normal be cause heparin acts on the intrinsic pathway. (However Heparin at very high concentrations within the sample may cause prolongation of both PT & APTT).