This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
COX pathway is inhibited by : 
Select and explain. 
A. Aspirin, B. Indomethacin, C. Diclofenac, D. All of these
D: All of these
Answer: D: All of these 
Explanation: Aspirin inhibits COX irreversibly by acetylating one of its serine residues; return of COX activity depends on synthesis of fresh enzyme. Other NSAIDS like indomethacin, diclofenac etc are competitive and reversible inhibitors of COX, return of activity depends on their dissociation from the enzyme which in turn is governed by the pharmacokinetic characteristics of the compound. Corticosteroids like betamethasone act by inhibiting phospholipase A2.