This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Major Depression, Subject name: Psychiatry
In depressions, there is deficiency of - 
Select and explain. 
A. 5-HT, B. Acetylcholine, C. Dopamine, D. GABA
A: 5-HT
Answer: A: 5-HT 
Explanation: Ans. is 'a' i.e., 5 - HT Neurotransmitters in mood disorderso Most accepted biochemical hypothesis for mood disorders is the monoamine hypothesis, according to which serotinin and norepinephrine are the major neurotransmitters involved in mood disorders : -Depression - Decrease in serotonin and norepinephrine. Serotonin is the most important neurotransmitter in depression.Mania - Increased level of norepinephrineo Patients suffering from severe depression with suicidal intent/attempt appear to have a marked decrease inserotinin.o Acetylcholine and GABA are the other neurotransmitters which are involved in mood disorders.