This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy, Subject name: Pharmacology
Alkalinization of urine ameliorates the toxicity of which of the following drugs 
Select and explain. 
A. Arabinoside -cytosine, B. Ifosfamide, C. Cisplatin, D. Methotrexate
D: Methotrexate
Answer: D: Methotrexate 
Explanation: refer Goodman Gilman 12/e p85 Alkalinization of urine speeds the clearance of weakly acidic drugs like. Aspirin Phenobarbitone Chlotpropapamide Methotrexate