This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
High risk of malignancy is seen in? 
Select and explain. 
A. Simple hyperplasia with atypia, B. Simple hyperplasia without atypia, C. Complex hyperplasia with atypia, D. Complex hyperplasia without atypia
C: Complex hyperplasia with atypia
Answer: C: Complex hyperplasia with atypia 
Explanation: Answer is option3, complex hyperplasia with atypia Endometrial hyperplasia with atypia is the least common type of hyperplasia, but is the type most likely to progress to type 1 endometrial carcinoma (1-3) which accounts for 97% of uterine cancers, whereas simple hyperplasia rarely progresses to carcinoma. >