This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Which of the following is not a pyrogenic cytokine 
Select and explain. 
A. Il_1, B. TNF, C. IFN _alpha, D. IL -18
D: IL -18
Answer: D: IL -18 
Explanation: Ref Harrison 18/e p 144;9/e p99 Interleukin-18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. This cytokine is produced by many immune cells and can modulate both innate and adaptive immunity and dysregulation can cause autoimmune or inflammatory diseases