This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Development of Lymphoma in Sjogren's syndrome is suggested by all of the following, except: 
Select and explain. 
A. Persistent parotid gland enlargement, B. Cyoglobulinemia, C. Leukopenia, D. High C4 Compement levels
D: High C4 Compement levels
Answer: D: High C4 Compement levels 
Explanation: Answer is D (High C4 complement levels): Development of Lymphoma in Sjogren's Syndrome is suggested by Low C4 Complement levels Lymphoma in Sjogren's syndrome (Extra-nodal, low grade marginal B cell Lymphomas) The development of Lymphomas in patients with Sjogren Syndrome is suggested BY : Persistent Parotid gland enlargement Purpura Leukopenia Cryoglobulinemia Low C4 complement levels Lymphoma is a well-known complication of Sjogren's syndrome; Most lymphomas are extra-nodal, low grade marginal B cell Lymphomas