This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Collapsing glomerulopathy, features are ? 
Select and explain. 
A. Tuft necrosis, B. Mesangiolysis, C. Parietal epithelial proliferation, D. Hyperophy and necrosis of visceral epithelium
D: Hyperophy and necrosis of visceral epithelium
Answer: D: Hyperophy and necrosis of visceral epithelium 
Explanation: Ans. is 'd' i.e., Hyperophy and necrosis of visceral epithelium o Collapsing glomerulopathy is actually an aggressive form of focal segmental glomerulosclerosis.o Focal segmental glomerulosclerosis is characterized by sclerosis of some but not all glomeruli (thus it is focal) andin the affected glomeruli only a poion of the capillary tuft is involved.o In contrast, collapsing glomerulopathy is characterized by collapse and sclerosis of the entire glomerular tuft (in addition to the usual focal segmental glomerular lesions).o Characteristic feature is proliferation and hiperophv of glomerular visceral epithelial cells.