This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Psychiatric Illness, Subject name: Pharmacology
Which of the following drugs is preferred for management of depression associated with insomnia? 
Select and explain. 
A. Miazapine, B. Venlafaxine, C. Seraline, D. Desipramine
A: Miazapine
Answer: A: Miazapine 
Explanation: In a depressed patient with significant insomnia, miazapine appears to be the most effective therapy. Miazapine is Atypical antidepressant MOA: Blocks a2 auto-( on NA neurons) and hetero (on 5-HT neurons) receptors enhancing both NA and 5-HT release. SSRIs commonly cause insomnia and avoided in patients with significant insomnia.