This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
What is the effect of progesterone on lipids? 
Select and explain. 
A. Lowers LDL, increases HDL, B. Lowers HDL and increases LDL, C. Lowers HDL and lowers LDL, D. Increases LDL and lowers HDL
C: Lowers HDL and lowers LDL
Answer: C: Lowers HDL and lowers LDL 
Explanation: Progesterone tend to lower HDL level. The mechanism appears to involve an increase in (Hepatic lipase)HL activity. It also decreases triglycerides and modestly lowers LDL levels due to decreased production of VLDL apoB. Ref: Principles and Practice of Endocrinology and Metabolism, 3e.