This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
MC gene involved in endometrial carcinoma 
Select and explain. 
A. PTEN, B. BRAF, C. KRAS, D. Mismatch repair genes
A: PTEN
Answer: A: PTEN 
Explanation: PTEN - Phosphatase & tensin homologue Cowden syndrome - AD disorder with tumours of skin appendages & increased incidence of Breast, Endometrium, Prostate & thyroid cancer Acts as TSG by serving as a break in the pro-growth PI3K/AKT pathway (MCly mutated p/w in human ca) By phosphorylating a number of substrates like BAD and MDM2, AKT enhances cell survival.