This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Autacoids, Subject name: Pharmacology
Rofecoxib was withdrawn due to: 
Select and explain. 
A. lschemic hea disease, B. Renal complication, C. Liver adenoma, D. Gastric ulcer
A: lschemic hea disease
Answer: A: lschemic hea disease 
Explanation: celecoxib,etoricoxib,parecoxib are available in India.Rofecoxib and valdecoxib were withdrawn within a few years of marketing for increasing cardiovascular risk by increasing the levels of TXA2 which increases platelet aggregation ESSENTIALS OF MEDICAL PHARMACOLOGY;7TH EDITION;KD TRIPATHI;PAGE NO 205