This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Endocrinology and breast, Subject name: Surgery
Sign seen in "Large duct papilloma" is? 
Select and explain. 
A. Nipple discharge, B. Breast mass, C. Skin excoriation, D. Lymph node involvement
A: Nipple discharge
Answer: A: Nipple discharge 
Explanation: Duct papilloma are epithelium lined true polyps of breast lctiferous duct. C/f: papilliferous swelling near the nipple orifice. Blood stained discharge from nipple is common, serous or serosanguinous dicharge can also occur. SRB's Manual of Surgery.Edition -5. Pg no:528