This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Which is the most specific autoantibody in SLE 
Select and explain. 
A. Anti - nuclear antibody, B. Anti - smith antibody, C. Anti - histone antibody, D. Anti - Ro antibody
B: Anti - smith antibody
Answer: B: Anti - smith antibody 
Explanation: Most sensitive - anti nuclear antibody.
Most specific - anti smith antibody.