This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Anti Microbial, Subject name: Pharmacology
Mechanism of action of Fluoroquinolones is 
Select and explain. 
A. Inhibit cell wall synthesis, B. Inhibit protein synthesis, C. Inhibit DNA gyrase, D. Interfere with DNA synthesis
C: Inhibit DNA gyrase
Answer: C: Inhibit DNA gyrase 
Explanation: (Inhibit DNA gyrase) (628, 647-KDT) (688-KDT 6th)Fluoroquinolones (FQs)* First generation FQs - Norfloxacin, Ciprofloxacin, Ofloxacin, Pefloxacin* Second generation FQs - Lomefloxacin, Sparfloxacin, Levofloxacin, Gatifloxacin, Moxifloxacin.* FQs inhibits the enzyme bacterial DNA gyrase, which nicks double stranded DNA, introduces negative super coils and then reseals the nicked ends.* FQ action is similar enzyme topo isomerase IV, which nicks and separates daughter DNA strands after DNAreplication.