This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: CHF, Angina Pectoris and Myocardial Infarction, Subject name: Pharmacology
Which of the following drug is associated with highest cardiac moality? 
Select and explain. 
A. Rofecoxib, B. Nicorandil, C. Losaan, D. Metoprolol
A: Rofecoxib
Answer: A: Rofecoxib 
Explanation: Rofecoxib is a selective COX-2 inhibitor that was withdrawn due to increased risk of MI. ARBs (losaan) and b blockers (metoprolol) are cardioprotective in CHF. These decrease the moality. Nicorandil is a K+ channel opener used in angina. It is cardioprotective by causing ischemic pre-conditioning.