This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Neurodegenerative Diseases, Subject name: Pathology
Neurofibrillary tangles are seen in? 
Select and explain. 
A. Alzheimer's disease, B. Lewy body disease, C. Neurosyphilis, D. Shy dragger syndrome
A: Alzheimer's disease
Answer: A: Alzheimer's disease 
Explanation: ANSWER: (A) Alzheimer's diseaseREF: Harrison's Internal Medicine 17th ed> Chapter 365. DementiaAlzheimer's disease most often presents with subtle onset of memory loss followed by a slowly progressive dementia that has a course of several years. Pathologically, there is diffuse atrophy of the cerebral cortex with secondary enlargement of the ventricular system. Microscopically, there are neuritic plaques containing A amyloid, silver-staining neurofibrillary tangles (NFTs) in neuronal cytoplasm, and accumulation of A42 amyloid in arterial walls of cerebral blood vessels.NFT also seen in supra nuclear palsy