This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Coagulation defect associated with increased coagulation are seen in 
Select and explain. 
A. Increased protein C, B. Increased protein S, C. Increased anti thrombin 3, D. Protein C resistance
D: Protein C resistance
Answer: D: Protein C resistance 
Explanation: Ref Harrison 16/e p1491 ,9/e p123 Protein C and protein S are two vitamin K-dependent proteins that act in a complex to proteolytically inacti- vate cofactors Va and VIIIa. Protein C activation by thrombomodulin was described earlier; protein S is a cofactor for protein C activity Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism