This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following is the principle disadvantage of depot progestin? 
Select and explain. 
A. Weight gain, B. Breast tenderness, C. Depression, D. Irregular menstrual bleeding and prolonged anovulation
D: Irregular menstrual bleeding and prolonged anovulation
Answer: D: Irregular menstrual bleeding and prolonged anovulation 
Explanation: None