This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Heme is conveed to bilirubin mainly in: 
Select and explain. 
A. Kidney., B. Liver., C. Spleen, D. Bone marrow.
C: Spleen
Answer: C: Spleen 
Explanation: C i.e. Spleen Breakdown of heme to bilirubin occurs in macrophages of the reticuloendothelial system mainly in the spleenQ also in the liver and bone marrow.