This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Sickle Cell Disease, G6PD deficiency and other Hemolytic Anemia, Subject name: Medicine
Life threatening intravascular hemolysis occur with sepsis due to which organism? 
Select and explain. 
A. Clostridium perfringens, B. Mycoplasma pneumonia, C. Pseudomonas, D. Klebsiella
A: Clostridium perfringens
Answer: A: Clostridium perfringens 
Explanation: Clostridium perfringens sepsis leads to life threatening intravascular hemolysis due to lecithinase activity. It occurs following open wounds, septic aboion, or due to a contaminated blood unit. Other infections causing hemolytic anemia: Malaria Shiga toxin-producing E. coli O157:H7