This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Heart, Circulation, and Blood, Subject name: Physiology
An arteriole with a damaged endothelial cell layer will not: 
Select and explain. 
A. Constrict when intravascular pressure is increased, B. Dilate when adenosine is applied to the vessel wall, C. Constrict in response to norepinephrine, D. Dilate in response to adenosine diphosphate (ADP) or acetylcholine
D: Dilate in response to adenosine diphosphate (ADP) or acetylcholine
Answer: D: Dilate in response to adenosine diphosphate (ADP) or acetylcholine 
Explanation: Ans. D. Dilate in response to adenosine diphosphate (ADP) or acetylcholineBoth adenosine diphosphate (ADP) and acetylcholine cause the release of NO from endothelial cells. The other choices involve mechanisms that function without endothelial cells.