This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Nervous system, Subject name: Pathology
Knife edge pattern of neuronal atrophy is associated with which of the degenerative disease of the coex 
Select and explain. 
A. Alzheimer's disease, B. Frontotemporal dementia, C. Pick's disease, D. Progressive supranuclear palsy
C: Pick's disease
Answer: C: Pick's disease 
Explanation: Pick's disease is characterized by a progressive frontotemporal lobar atrophy, gliosis, severe neuronal loss, aB-crystallin-immunoreactive ballooned neurons, and the presence of argyrophilic (but Gallyas-negative) neuronal inclusions, the Pick bodies, in the cerebral coex and some subcoical structures. The "knife-edge" coical atrophy is frequently asymmetric and predominates in the frontal and temporopolar regions Refer robbins 9/e 840