This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Which vitamin deficiency is responsible for neonatal seizure - 
Select and explain. 
A. Pyridoxine, B. Vitamin C, C. Thiamine, D. Cobalamin
A: Pyridoxine
Answer: A: Pyridoxine 
Explanation: Ans. is 'a' i.e., Pyridoxin o Pyridoxine (Vitamin B6) dependency with seizures is an autosomal recessive condition. o It is due to GABA deficiency in the brain, which is presumbly caused by decreased activity of GAD (glutamic acid decarboxylase). o Administration of large doses of pyridoxin usually results in a dramatic improvement of both seizures and EEG abnormalities, as pyridoxin acts as a cofactor for GAD and improves its activity.