This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
A patient presents with a wound on his leg. It heals six weeks later. Which of the following mediators is involved in promoting wound healing? 
Select and explain. 
A. TGF -Beta, B. TNF-Alpha, C. INF-Beta, D. IFN-Alpha
A: TGF -Beta
Answer: A: TGF -Beta 
Explanation: TGF b (Transforming growth factor b) was responsible for the wound healing. It inhibits T- and B-cell proliferation. It acts as a growth factor for fibroblasts and also promotes class switching of B cells to IgA. TGF b is produced by T and B cells. IL-10 is also involved in wound healing and suppression of inflammation. IFN a inhibits viral replication, activate NK cells, and regulates the activity of macrophages and T cells. TNF a is involved in tumour cytotoxicity, phagocytic cell activation, antiviral and antiparasitic effects. it is an acute phase protien. INF b has antiviral activity. Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition