This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Regarding oncogenesis: All are true except: 
Select and explain. 
A. Topoisomerase II causes breaks in strands, B. p53 is the most common oncogene mutation causing malignancy in humans, C. At G2-M phase there is loss of inhibitors controlling cell-cycle, D. Decrease in telomerase activity causes anti-tumor effects
B: p53 is the most common oncogene mutation causing malignancy in humans
Answer: B: p53 is the most common oncogene mutation causing malignancy in humans 
Explanation: None