This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Fixed drug combination have all advantages except ? 
Select and explain. 
A. Increased compliance, B. Decreased incidence of drug resistance, C. No dose adjustment in combination preparations, D. Synergistic effect of some drug combinations
C: No dose adjustment in combination preparations
Answer: C: No dose adjustment in combination preparations 
Explanation: Ans. is 'c' i.e., No dose adjustment in combination preparation. FDCs offer simple dosage schedule which improves patient compliance and therefore improves treatment outcomes. Impoant in elderly patients or patients suffering from multiple disorders. More economic than single ingredient drugs. Such reduced "pill burden" can greatly enhance the overall treatment outcome.