This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
All of the following are poor prognostic markers of CA Breast except 
Select and explain. 
A. PCNA Positivity, B. ER positivity, C. Her 2 neu positivity, D. p53 over expression
B: ER positivity
Answer: B: ER positivity 
Explanation: Answer- B. ER positivityPatients with hormone receptor positive tumor show good response to hormone therapy.Tumors positive for estrogen or progesterone receptors have a higher response rate to endocrine therapy than tumors that do not express estrogen or progesterone receptors.Tumors positive for one receptor and not the other have an intermediate response rate.