This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Nitrates are contraindicated with 
Select and explain. 
A. Sulphonylureas, B. Immunomodulators, C. SSRI's, D. PDE-5 inhibitors
D: PDE-5 inhibitors
Answer: D: PDE-5 inhibitors 
Explanation: Sildenafil & Tadalafil are the PDE-5 inhibitors which are contrainidicated with Nitrates to prevent severe hypotension.