This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: DNA Replication , Subject name: Biochemistry
Function of DNA ligase - 
Select and explain. 
A. Cutting of DNA at specific site, B. Preventing negative supercoil, C. To seal and nick okazaki fragments, D. DNA polymerization
C: To seal and nick okazaki fragments
Answer: C: To seal and nick okazaki fragments 
Explanation: Ans. is 'c' i.e., To seal and nick okazaki fragments ProteinFunctionDNA polymerasesDeoxynucleotide polymerizationHelicasesProcessive unwinding of DNATopoisomerasesRelieve torsional strain that results from helicase-induced unwindingDNA primaseInitiates synthesis of RNA primersSingle-strand binding proteinsPrevent premature reannealling of dsDNADNA ligaseSeals the single strand nick between the nascent chain and Okazaki fragments on lagging strand