This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chemotherapy: General Principles, Subject name: Pharmacology
Which of the followign drugs require dose adjustment in renal failure? 
Select and explain. 
A. Cefoperazone, B. Doxycycline, C. Streptomycin, D. Rifampicin
C: Streptomycin
Answer: C: Streptomycin 
Explanation: Ans. (C) Streptomycin(Ref: Katzung 10/e p835 KDT 8/e p746)Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas doxycycline, rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure.