This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: G.I.T, Subject name: Surgery
Crohn's disease is associated with polymorphisms in 
Select and explain. 
A. NOD2/CARD 15 gene, B. P53 gene, C. Philadelphia chromosome, D. APC/Beta catenin
A: NOD2/CARD 15 gene
Answer: A: NOD2/CARD 15 gene 
Explanation: Individuals with allelic variants of CARD15/NOD2 have a 40 fold relative risk for Crohn's disease compared with general population. Reference : Sabiston Textbook of Surgery, 19th Edition, page no = 1245.