This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Gynaecology & Obstetrics
Non hormonal drug to prevent post menopausal osteoporosis is: 
Select and explain. 
A. Alendronate, B. Estrogen, C. Raloxifene, D. Parathyroid
A: Alendronate
Answer: A: Alendronate 
Explanation: Alenderonate, etidronate, pamidronate, and Ibandronate are bisphosphonates which inhibit bone resorption, and are very effective for both osteoporosis prevention and treatment.
Uses:
• First line drugs for treating postmenopausal osteoporosis
• Paget’s disease
• Osteolytic bone metastasis.
Caution: Patient should be instructed to take these drugs on an empty stomach with a large glass of water and then to remain upright for atleast 30 minutes as its major side effect is GI upset.
Route of administration: Oral or IV infusion
Now lets have a look at other options:
• Raloxifene: It is a selective estrogen receptor modulator which is also useful in management of osteoporosis but it is a hormonal preparation.
• Parathyroid hormone: It is a novel therapy for osteoporosis. Unlike most of the treatments for osteoporosis that inhibit bone resorption, parathyroid hormone stimulates new bone formation. It is given by daily subcutaneous injection.
Also Know:
Other non-hormonal drugs used for treatment of osteoporosis:
a. Calcium
b. Vitamin D
c. Calcitonin
d. Slow releasing sodium fluoride.