This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Epilepsy, Subject name: Pharmacology
Which is gender specific adverse effect of valproate 
Select and explain. 
A. PCOD, B. Weight gain, C. Alopecia, D. Hepatotoxicity
A: PCOD
Answer: A: PCOD 
Explanation: Valproate Adverse effects a) Hepatotoxicity Due to a metabolite of valproate. This metabolite is produced more if given with carbamazepine like drugs. So they produce more hepatotoxicity b) Pancreatitis c) Polycystic ovarian disease