This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Not true about apoptosis ? 
Select and explain. 
A. Increase in lysosomal enzyme, B. Increase in caspases, C. Phosphatidyl serine has impoant role, D. Internucleosomal cleavage of nucleus
A: Increase in lysosomal enzyme
Answer: A: Increase in lysosomal enzyme 
Explanation: Ans. is 'a' i.e., Increase in lysosomal enzyme Apoptosis Caspases are central to the pathogenesis of apoptosis. The lysis in apoptosis is caused due to action of caspase. Mitochondrias are the most impoant organelles involved in initiation and regulation of apoptosis. Hallmark of apoptosis is permeability of the mitochondrial membrane. Normally phosphatidyl serine is located on the inner cytosolic surface of plasma membrane In apoptotic cell this phosphatidyl serine is translocated to the outer (extracellular) surface of plasma membrane. Lysosome and other organelles remain intact.