This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
How is endotoxin shock initiated? 
Select and explain. 
A. Endothelial injury, B. Peripheral vasodilation, C. Increased vascular permeability, D. Cytokines action
A: Endothelial injury
Answer: A: Endothelial injury 
Explanation: . Endothelial injury