This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: C.V.S, Subject name: Pharmacology
Glyceryl trinitrate is given by sublingual route because of: 
Select and explain. 
A. Short t1/2 in plasma, B. High hepatic first pass metabolism, C. High bioavailability by oral route, D. Extensive protein binding
B: High hepatic first pass metabolism
Answer: B: High hepatic first pass metabolism 
Explanation: Ans. (B) High hepatic first pass metabolism(Ref: KDT 8th/e p588)Main advantage of sublingual route of drug administration is that liver is bypassed and drugs with high first pass metabolism are absorbed directly into systemic circulation.