This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General anatomy, Subject name: Anatomy
Catastrophic variant of Ehler Danlos syndrome is 
Select and explain. 
A. I, B. II, C. III, D. IV
D: IV
Answer: D: IV 
Explanation: Ehlers danlos syndrome comprise group of clinically and genetically heterogeneous group of disorder that result from defects in synthesis or structure of fibrillar collagen. Ref Robbin's 9th/146