This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
HMB 45 is a tumor marker for 
Select and explain. 
A. Neuroblastoma, B. Neurofibroma, C. Malignant melanoma, D. Angiosarcoma
C: Malignant melanoma
Answer: C: Malignant melanoma 
Explanation: Malignant melanoma expresses HMB45 ,S-100 and vimentin 
HMB 45 is present in melanosome and is more specific 
S-100 is more sensitive but is non specific (also present in LAngerhan's cell histiocytosis, neural tumors and sarcomas like Liposarcoma and Chondrosarcoma)