This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
AML with worst prognosis is : 
Select and explain. 
A. 8/21 translocation, B. Inversion 16, C. Normal Cytogenetics, D. Monosomy 7
D: Monosomy 7
Answer: D: Monosomy 7 
Explanation: Answer is D (Monosomy 7) Patient with a complex karyotype, inv (3), or -7 (monosomy) have a poor prognosis. - Harrison