This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Congenital Infections, Subject name: Pediatrics
Trans-placental spread is least associated with: 
Select and explain. 
A. Hepatitis B virus, B. Rubella virus, C. Herpes Simplex virus, D. Human Immunodeficiency Virus
C: Herpes Simplex virus
Answer: C: Herpes Simplex virus 
Explanation: For HSV infection most common mode of transmission is direct contact between mucocutaneous surfaces Source of virus in neonatal infections is typically the mother, & transmission generally occurs during delivery.