This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Preoperative assessment and monitoring in anaesthesia, Subject name: Anaesthesia
A 16-year-old adolescent boy with a history of severe hemophilia A is undergoing an elective inguinal hernia repair. Which of the following is the best option for preventing or treating a bleeding complication in the setting of this disease? 
Select and explain. 
A. Fresh-frozen plasma, B. Combination of desmopressin and fresh-frozen plasma, C. Combination of e-aminocaproic acid and desmopressin, D. Factor IX concentrate
C: Combination of e-aminocaproic acid and desmopressin
Answer: C: Combination of e-aminocaproic acid and desmopressin 
Explanation: Hemophilia A is a coagulation disorder resulting from a deficiency or abnormality of factor VIII. Desmopressin (DDAVP) is a synthetic analogue of antidiuretic hormone that increases levels of factor VIII and von Willebrand factor. DDAVP can be used alone for mild hemophilia A, but is ineffective in severe forms of the disease. For severe hemophilia A, DDAVP is given in combination with an inhibitor of fibrinolysis such as eaminocaproic acid (AMICAR). Although FFP contains factor VIII, the levels are too low to prevent or control bleeding in hemophiliacs. Other agents used in treatment of hemophilia A include cryoprecipitate and specific factor VIII concentrates.