This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Intracellular Accumulations, Subject name: Pathology
Birbeck granules in cytoplasm is seen in - 
Select and explain. 
A. Langerhans cell histiocytosis, B. Hodgkin's lymphoma, C. Non hodgkins lymphoma, D. Gastrointestinal stromal tumor
A: Langerhans cell histiocytosis
Answer: A: Langerhans cell histiocytosis 
Explanation: Ans. is 'a' i.e., Langerhans cell histiocytosis Birbeck granules are characteristic of langerhans cell histiocytosisTumour cells in the laneerhan \ cell histiocytosis are derived from dendritic cells and express :-o S-100o CDlao HLA-DRo These cells are characterized by the presence of birbeck granules in their cytoplasm unde rthe electron micro-scope, Birbeck granules have pentalaminar, rodlike tuular appearance and sometimes a dilated terminal end itennis-racket appearance)