This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: General pathology, Subject name: Pathology
HIV mostly affects which cells? 
Select and explain. 
A. CD4 cells, B. CD 8 cells, C. T cells, D. Plasma cells
A: CD4 cells
Answer: A: CD4 cells 
Explanation: harshmohan textbook of pathology 7th edition. *the pathogenesis of HIV infection is largely related to the depletion of CD4 + T cells resulting in preformed immunosuppression .Selective tropism for CD4+ molecule receptors, gp 120 envelope glycoprotein of HIV has selective tropism for the cells containing CD 4 molecules on their surface,most impoantly CD4+T cells