This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Other topics and Adverse effects, Subject name: Pharmacology
Sirolimus is more likely than cyclosporine to cause: 
Select and explain. 
A. Hypeension, B. Osteoporosis, C. Renal insufficiency, D. Thrombocytopenia
D: Thrombocytopenia
Answer: D: Thrombocytopenia 
Explanation: (Ref: KDT 6/e p840) Cyclosporine and tacrolimus cause nephrotoxicity as an adverse effect. Sirolimus (rapamycin) results in bone marrow suppression and thus may cause anemia, thrombocytopenia and leukopenia.