This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Surgery
Local anesthetic with highest local tissue irritancy is 
Select and explain. 
A. Procaine, B. Chloroprocaine, C. Lignocaine, D. Bupivacaine agents
D: Bupivacaine agents
Answer: D: Bupivacaine agents 
Explanation: None