This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Endogenous pyrogens act by ? 
Select and explain. 
A. Increasing heat generation, B. Raising thermostat point of hypothalamus, C. Causing vasoconstriction, D. By Non-shivering thermogenesis
B: Raising thermostat point of hypothalamus
Answer: B: Raising thermostat point of hypothalamus 
Explanation: Ans. is 'b' i.e., Raising thermostat point of hypothalamusBacterial toxins (exogenous pyrogens) stimulate inflammatory cells to secrete pyrogenic cytokines (endogenous pyrogens), e.g. IL-I, TNF-a , and IL-6.These endogenous pyrogenes stimulate PGE2 release in hypothalamus, which raises temperature set point of hypothalamus to cause fever.