This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Hypergonadotropic hypogonadism is sean in all except? 
Select and explain. 
A. Turner syndrome, B. Down syndrome, C. Klinefelter syndrome, D. Swyer's syndrome
B: Down syndrome
Answer: B: Down syndrome 
Explanation: Ans. is 'b' i.e., Down syndrome Hypergonadotropic hypogonadism Also K/a primary or peripheral hypogonadism. Characterised by hypogonadism due to an impaired response of the gonads to the gonadotropin, FSH and LH. In turn a lack of sex steroid production and elevated gonadotropin level. Causes : Chromosomal abnormalitis Turner's syndrome Klinefelter syndrome Swyer's syndrome Enzyme defect 17 , hydroxylase 17, 20 lyase deficiency