This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Physiology
Effect of infusion of hypotonic saline? 
Select and explain. 
A. Increased ICF only, B. Increased ECF only, C. Increased in both ICF and ECF, D. Increased ICF and decreased ECF
C: Increased in both ICF and ECF
Answer: C: Increased in both ICF and ECF 
Explanation: Ans. is 'c' i.e., Increased in both ICF and ECFAfter infusion of hyptonic saline causes a decline in plasma osmolality and a shift of water into interstial space (as water moves from higher osmolarity to lower osmolarity), causing decrease in ICF osmolality.This results in shift of water from ECF to ICF.Finally, both ECF and ICF compaments are increased (due to increases water) and osmolality of both compament are decreased.