This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Chronic Kidney Disease & Diabetic Nephropathy, Subject name: Medicine
Which of the following drug does not cause nephrotoxicity? 
Select and explain. 
A. Cisplatin, B. Cyclophosphamide, C. Cyclosporine, D. Sirolimus
D: Sirolimus
Answer: D: Sirolimus 
Explanation: Sirolimus is a non-nephrotoxic -mTOR inhibitor with a long half-life of 62 hours. It was the first mTOR inhibitor to be developed in solid organ transplantation as it inhibits cell proliferation .