This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following drug is an inverse agonist at H3 receptors used for Narcolepsy? 
Select and explain. 
A. Dexmedetomidine, B. Pitolisant, C. Icatibont, D. Secukinumab
B: Pitolisant
Answer: B: Pitolisant 
Explanation: Pitolisant (Tiprolisant) is a inverse agonist of H3 receptors approved for Narcolepsy. H3 receptors are presynaptic receptors and inverse agonist will lead to increased histamine release and promote wakefulness.