This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Diuretics and Antidiuretics, Subject name: Pharmacology
Which diuretic could be considered appropriate for combining with ACE inhibitors? 
Select and explain. 
A. Spironolactone, B. Eplerenone, C. Hydrochlorothiazide, D. Amiloride
C: Hydrochlorothiazide
Answer: C: Hydrochlorothiazide 
Explanation: Ans. (C) Hydrochlorothiazide(Ref: Katzung 10/e p571; KDT 8/e p632)*ACE inhibitors are contra-indicated in the presence of hyperkalemia. Aldosterone antagonists (like spironolactone and epleronone) and epithelial sodium channel blockers (like amiloride and triamterene) are potassium sparing diuretics and should not be combined with ACE inhibitors. Thiazides on the other hand cause hypokalemia and can be combined with ACE inhibitors.