This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Medicine
Which one of the following is of most serious prognostic significance in a patient of essential hypertension - 
Select and explain. 
A. Diastolic blood pressure greater than 130 mmHg, B. Transient ischaemic attacks, C. Left ventricular hypertrophy, D. Papilloedema and progressive renal failure
D: Papilloedema and progressive renal failure
Answer: D: Papilloedema and progressive renal failure 
Explanation: None