This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Anaesthesia
Local anaesthetics acts by inhibiting: March 2012 
Select and explain. 
A. Sodium channels, B. Potassium channels, C. Calcium channels, D. Magnesium channels
A: Sodium channels
Answer: A: Sodium channels 
Explanation: Ans: A i.e. Sodium channels Local anaesthetics act by inhibiting sodium channels from inside Local anesthetics Generally blocks: Sodium channels Potency of LA depends on: Lipid solubility Susceptibility of fibres to LA: Type B > type C > type A Amide linked LA: - Lidocaine, - Bupivacaine etc. Ester linked LA: - Cocaine,