This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pediatrics
Which among the following can cause congenital hea block? 
Select and explain. 
A. Maternal SLE, B. Down's syndrome, C. Edward's syndrome, D. Phenylketonuria
A: Maternal SLE
Answer: A: Maternal SLE 
Explanation: SLE with high SSA titer is said to predispose to congenital hea block in the child. Complete atrioventricular block (CAVB) occurs in as many as 5% of children born to mothers with anti-Ro antibody, which can be seen with subclinical or clinical maternal lupus erythematosus, maternal Sjogren syndrome, or another maternal autoimmune disease. After bih, the children may present with varying degrees of hea block, including CAVB, cardiomyopathy, and other manifestations of neonatal lupus syndrome. However, the majority of infants who are born to these mothers do not manifest AV block. Hereditary diseases such as Hurler cardiomyopathy and Hunter cardiomyopathy can be associated with CAVB.