This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunology, Subject name: Microbiology
Chediak higashi syndrome, true is - 
Select and explain. 
A. Defect in phagocytosis, B. Neutropenia, C. Agammaglobulinemia, D. IgA defficiency
A: Defect in phagocytosis
Answer: A: Defect in phagocytosis 
Explanation: Chediak-Higashi syndrome is autosomal recessive disorder. Polymorphonuclear leucocytes here possess larger lysosomes. These abnormal lysosomes do not fuse with phagosome. - this leucocytes posses diminished phagocytic activity. Reference : Baveja text book of microbiology, 4th edition, pg no:153 <\p>