This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Pharmacokinetics, Subject name: Pharmacology
All of the following are advantages of transdermal drug delivery systems EXCEPT: 
Select and explain. 
A. They produce high peak plasma concentration of the drug, B. They produce smooth and nonfluctuating plasma concentration of the drug, C. They minimize inter-individual variations in the achieved plasma drug concentration, D. They avoid hepatic first pass metabolism of the drug
A: They produce high peak plasma concentration of the drug
Answer: A: They produce high peak plasma concentration of the drug 
Explanation: Transdermal route is employed for highly lipid soluble drugs that can traverse intact skin. The size of the pores in transdermal patch is adjusted to produce a uniform and smooth absorption of the drug. This will thus, produce a delayed and smaller peak in the plasma concentration. As the drug is going directly in the bloodstream, first pass metabolism is avoided. Eg : Transdermal patch- Rotigotine is used in Parkinson disease