This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Murmurs, Subject name: Medicine
A 75-year-old man presents to his GP for a routine check-up. On examination the GP hears a high-pitched diastolic murmur, heard loudest at the right sternal edge and on expiration. Given the likely diagnosis, which of the following is NOT a risk factor for this condition? 
Select and explain. 
A. Ankylosing spondylitis, B. Marfan's syndrome, C. Holt Oram Syndrome, D. Infective endocarditis
C: Holt Oram Syndrome
Answer: C: Holt Oram Syndrome 
Explanation: Aoic regurgitation, High pitched diastolic murmur heard in case of AR Best heard on the left side. Option A: MC cardiovascular disease in Ankylosing spondylitis =A.R. Option B: Marfan syndrome is a Risk factor. Option C: ASD+ skeletal defects/Absent radius bone - Holt Oram Syndrome = In ASD shunt murmur is absent, in ASD it is flow murmur | Mid diastolic murmur Option D: Inf. endocarditis- bacteria will invade the valve leaflet & will contribute to developing Diastolic Murmur.