This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: All India exam, Subject name: Physiology
All the following are signs of necrosis Except 
Select and explain. 
A. Lipofuscin, B. Cell Membrane Rupture, C. Karyolysis, D. Karyorrhexis
A: Lipofuscin
Answer: A: Lipofuscin 
Explanation: Lipofuscin, also known as "wear and tear pigment," appears in the form of brown granules in the cytoplasm of living cells but is not a sign of necrosis. Pyknosis, karyolysis, and karyorrhexis terms that describe nuclear changes in dead or irreversibly injured cells. Cell membrane rupture is also associated with cell death, and is a sign of irreversible cell injury.