This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
In which of the following carcinomas of breast, loss of E-cadherin plays a vital role in pathogenesis? 
Select and explain. 
A. Paget's disease, B. Ductal carcinoma, C. Lobular carcinoma, D. Medullary carcinoma
C: Lobular carcinoma
Answer: C: Lobular carcinoma 
Explanation: The main pathogenesis underlying Lobular carcinoma is accquired loss of the tumor suppressive adhesion protein E-cadherin, also called as CDH-1.