This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: NSAIDs, Gout and Rheumatoid Ahritis, Subject name: Pharmacology
Which of the following drug can be used for closure of patent ductus aeriosus? 
Select and explain. 
A. Paracetamol, B. Alprostadil, C. Indomethacin, D. Celecoxib
C: Indomethacin
Answer: C: Indomethacin 
Explanation: PGE2 and PGI2 keeps ductus aeriosus patent. If ductus aeriosus fails to close (patent ductus aeriosus) at bih, NSAIDs like aspirin and indomethacin are given to close it. In some congenital hea diseases (like transposition of great vessels), it becomes essential to keep ductus aeriosus patent before surgery. For this indication, alprostadil (PGE1) and epoprostenol (PGI2) can be given intravenously.