This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: Immunomodulators, Subject name: Pharmacology
Capillary leak syndrome is caused by which of the following drug? 
Select and explain. 
A. Fligrastim, B. Sargramostim, C. Peg filgrastim, D. Darbeptoin
B: Sargramostim
Answer: B: Sargramostim 
Explanation: Capillary leak syndrome is usually seen with Sargramostim or GM CSFGM-CSF can cause more severe side effects, paicularly at higher doses. These include fever, malaise, ahralgias, myalgias, and a capillary leak syndrome characterized by peripheral edema and pleural or pericardial effusions.G CSF/GM CSF analogs are used for treatment and prevention of cancer chemotherapy-induced anemia, neutropenia, thrombocytopenia etcRef: Goodman Gillman 12th ed. Pg: 1074