This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pathology
Chronic Active Hepatitis is most reliably distinguished from chronic Persistent hepatitis by the presence of 
Select and explain. 
A. Extrahepatic manifestation, B. Significant titre of antismooth muscle antibody, C. Characteristic liver histology, D. Hepatitis B surface antigen
C: Characteristic liver histology
Answer: C: Characteristic liver histology 
Explanation: Minimal chronic hepatitis (previously called chronic persistent hepatitis).
The portal chronic inflammation is mild and is restricted to the portal triads without extension into the Liver lobule across the limiting plate.
Chronic active hepatitis → characterized by continuing necrosis of Liver cells. The severe inflammation disrupts the limiting plate.