This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: ENT
Mikulicz and Russell bodies are characteristic of 
Select and explain. 
A. Lethal midline granuloma, B. Plasma cell disorder, C. Rhinoscleroma, D. Rhinosporidiosis
C: Rhinoscleroma
Answer: C: Rhinoscleroma 
Explanation: Biopsy shows infiltration of submucosa with plasma cells, lymphocytes, eosinophils, mikulicz cells and Russell bodies.
The latter two are diagnostic features of the disease RHINOSCLEROMA. Mikulicz cells are large foam cells with a central nucleus and vacuolated cytoplasm containing causative bacilli. Russell bodies are homogenous eosinophilic inclusion bodies found in the plasma cells. They occur due to the accumulation of immunoglobulins secreted by the plasma cells.