This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Which of the following inhalational agent should not be used in closed circuit? 
Select and explain. 
A. Desflurane, B. Sevoflurance, C. Both 1 & 2, D. Isoflurane
B: Sevoflurance
Answer: B: Sevoflurance 
Explanation: Sevoflurane, Trilene & Methoxyflurane are avoided in closed circuit.
Sevoflurane reacts with sodalime to produce compound A which is nephrotoxic.
Trilene reacts with sodalime and produces phosgene gas and dichloroacetylene which can cause ARDS & seizures respectively.
Methoxyflurane can react with rubber tubing of closed circuit.