This is a real-world medical entrance exam question, please give the true answer based on the question and selection. Topic name: None, Subject name: Pharmacology
Enzyme inactivation is the main mode of resistance to : 
Select and explain. 
A. Aminoglycosides, B. Quinolones, C. Rifamycins, D. Glycopeptides
A: Aminoglycosides
Answer: A: Aminoglycosides 
Explanation: Resistance to quinolones is due to altered DNA gyrase, to rifamycin is due to mutation in gene rpoB reducing its ability for the target and for glycopeptides like vancomycin due to reduced affinity for target site.