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PMC3131785 | tbl3 | <table-wrap><label>Table 3</label><caption><title>Antiproliferative Activity of Compounds 12, 26, 31, 35, 36, 38, 44–46, 60, Colchicine, Paclitaxel, and Vinblastine on CHO, K562, L1210, P388D1, B16F0, DU-145, HT-1080, MDA-MB-231, SKOV3, and CEM Cells</title></caption><table><colgroup><col/><col/><col/><col/><col/><col/><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th> </th>
<th colspan="10">IC50 (nM)d<hr/></th>
</tr>
<tr>
<th>compd</th>
<th>CHO</th>
<th>K562</th>
<th>L1210</th>
<th>P388D1</th>
<th>B16F0</th>
<th>DU 145</th>
<th>HT-1080</th>
<th>MDA-MB-231</th>
<th>SKOV3</th>
<th>CEM</th>
</tr></thead><tbody>
<tr>
<td>12</td>
<td>240</td>
<td>240</td>
<td>250</td>
<td>260</td>
<td>510</td>
<td>650</td>
<td>240</td>
<td>760</td>
<td>320</td>
<td>250</td>
</tr>
<tr>
<td>26</td>
<td>18</td>
<td>18</td>
<td>21</td>
<td>19</td>
<td>49</td>
<td>57</td>
<td>24</td>
<td>69</td>
<td>29</td>
<td>19</td>
</tr>
<tr>
<td>31</td>
<td>73</td>
<td>65</td>
<td>67</td>
<td>76</td>
<td>91</td>
<td>170</td>
<td>65</td>
<td>100</td>
<td>72</td>
<td>68</td>
</tr>
<tr>
<td>35</td>
<td>32</td>
<td>18</td>
<td>19</td>
<td>20</td>
<td>65</td>
<td>72</td>
<td>34</td>
<td>55</td>
<td>42</td>
<td>20</td>
</tr>
<tr>
<td>36</td>
<td>18</td>
<td>16</td>
<td>17</td>
<td>19</td>
<td>46</td>
<td>58</td>
<td>19</td>
<td>45</td>
<td>22</td>
<td>17</td>
</tr>
<tr>
<td>38</td>
<td>17</td>
<td>14</td>
<td>19</td>
<td>18</td>
<td>30</td>
<td>57</td>
<td>19</td>
<td>48</td>
<td>23</td>
<td>17</td>
</tr>
<tr>
<td>44</td>
<td>7.3</td>
<td>7.5</td>
<td>6.4</td>
<td>7.8</td>
<td>25</td>
<td>25</td>
<td>8.2</td>
<td>14</td>
<td>6.8</td>
<td>7.1</td>
</tr>
<tr>
<td>45</td>
<td>7.4</td>
<td>2.5</td>
<td>5.4</td>
<td>2.7</td>
<td>9.2</td>
<td>8.5</td>
<td>5.9</td>
<td>9.4</td>
<td>6.1</td>
<td>7.1</td>
</tr>
<tr>
<td>46</td>
<td>17</td>
<td>7.2</td>
<td>9.6</td>
<td>7.4</td>
<td>41</td>
<td>66</td>
<td>18</td>
<td>26</td>
<td>16</td>
<td>16</td>
</tr>
<tr>
<td>60</td>
<td>230</td>
<td>180</td>
<td>140</td>
<td>240</td>
<td>250</td>
<td>550</td>
<td>190</td>
<td>360</td>
<td>210</td>
<td>200</td>
</tr>
<tr>
<td>Cola</td>
<td>220</td>
<td>6.8</td>
<td>6.9</td>
<td>28</td>
<td>13</td>
<td>10</td>
<td>1.1</td>
<td>2.9</td>
<td>2.1</td>
<td>7.9</td>
</tr>
<tr>
<td>Pacb</td>
<td>170</td>
<td>0.71</td>
<td>0.40</td>
<td>35</td>
<td>28</td>
<td>1.3</td>
<td>0.15</td>
<td>9.1</td>
<td>2.6</td>
<td>0.27</td>
</tr>
<tr>
<td>Vblc</td>
<td>17</td>
<td>0.36</td>
<td>0.16</td>
<td>1.8</td>
<td>0.099</td>
<td>0.063</td>
<td>0.099</td>
<td>0.12</td>
<td>0.039</td>
<td>0.38</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>Col, colchicine.</p></fn><fn><label>b</label><p>Pac, paclitaxel.</p></fn><fn><label>c</label><p>Vbl, vinblastine.</p></fn><fn><label>d</label><p>IC50: concentration of drug inhibiting cell growth by 50%.</p></fn></table-wrap-foot></table-wrap> | {
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"{\"value\": \"67\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"76\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"91\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"170\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"65\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"100\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"72\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"68\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"35\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"65\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"72\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"34\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"55\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"42\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"36\", \"type\": \"Other\"}",
"{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"46\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"58\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"45\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"22\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"38\", \"type\": \"Other\"}",
"{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"14\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"30\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"57\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"48\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"23\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"44\", \"type\": \"Other\"}",
"{\"value\": \"7.3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"7.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
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"{\"value\": \"25\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"25\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"8.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"14\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
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"{\"value\": \"7.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"45\", \"type\": \"Other\"}",
"{\"value\": \"7.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"2.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
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"{\"value\": \"2.7\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
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"{\"value\": \"8.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"5.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"9.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"6.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"7.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"46\", \"type\": \"Other\"}",
"{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"7.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"9.6\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"7.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"41\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"66\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"26\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"60\", \"type\": \"Other\"}",
"{\"value\": \"230\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"180\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"140\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"240\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
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"{\"value\": \"550\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"190\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"360\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"210\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"200\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"220\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"6.8\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"6.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"28\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"13\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
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"{\"value\": \"170\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"0.71\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"0.40\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"35\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"28\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"1.3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"0.15\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"9.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"2.6\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"0.27\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.36\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"1.8\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.099\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.063\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.099\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.12\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.039\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.38\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}"
]
} |
|
PMC3131785 | tbl4 | <table-wrap><label>Table 4</label><caption><title>Antiproliferative Activity of Compounds 12, 26, 31, 35, 36, 38, 44–46, 60, Colchicine, Paclitaxel, and Vinblastine on Chemoresistant TAX 5-6, CHO-VV 3-2, and CEM-VLB Cells</title></caption><table><colgroup><col/><col/><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>compd</th>
<th>IC50 (nM)dCHO-TAX 5-6e</th>
<th>ratio resistant/wild-typeCHO-TAX 5-6/CHO</th>
<th>IC50 (nM)dCHO-VV 3-2f</th>
<th>ratio resistant/wild-typeCHO-VV 3-2/CHO</th>
<th>IC50 (nM)dCEM-VLBg</th>
<th>ratio resistant/wild-typeCEM-VLB/CEM</th>
</tr></thead><tbody>
<tr>
<td>12</td>
<td>200</td>
<td>0.83</td>
<td>250</td>
<td>1.0</td>
<td>320</td>
<td>1.3</td>
</tr>
<tr>
<td>26</td>
<td>14</td>
<td>0.78</td>
<td>21</td>
<td>1.2</td>
<td>23</td>
<td>1.2</td>
</tr>
<tr>
<td>31</td>
<td>38</td>
<td>0.52</td>
<td>74</td>
<td>1.0</td>
<td>87</td>
<td>1.3</td>
</tr>
<tr>
<td>35</td>
<td>12</td>
<td>0.38</td>
<td>39</td>
<td>1.2</td>
<td>32</td>
<td>1.6</td>
</tr>
<tr>
<td>36</td>
<td>9.3</td>
<td>0.52</td>
<td>20</td>
<td>1.1</td>
<td>20</td>
<td>1.2</td>
</tr>
<tr>
<td>38</td>
<td>8.9</td>
<td>0.52</td>
<td>20</td>
<td>1.2</td>
<td>18</td>
<td>1.1</td>
</tr>
<tr>
<td>44</td>
<td>5.2</td>
<td>0.71</td>
<td>15</td>
<td>2.1</td>
<td>9.2</td>
<td>1.3</td>
</tr>
<tr>
<td>45</td>
<td>3</td>
<td>0.41</td>
<td>8.2</td>
<td>1.1</td>
<td>9.5</td>
<td>1.3</td>
</tr>
<tr>
<td>46</td>
<td>6.1</td>
<td>0.36</td>
<td>20</td>
<td>1.2</td>
<td>19</td>
<td>1.2</td>
</tr>
<tr>
<td>60</td>
<td>86</td>
<td>0.37</td>
<td>260</td>
<td>1.1</td>
<td>270</td>
<td>1.4</td>
</tr>
<tr>
<td>Cola</td>
<td>140</td>
<td>0.64</td>
<td>620</td>
<td>2.8</td>
<td>360</td>
<td>46</td>
</tr>
<tr>
<td>Pacb</td>
<td>520</td>
<td>3.1</td>
<td>140</td>
<td>0.82</td>
<td>3340</td>
<td>12370</td>
</tr>
<tr>
<td>Vblc</td>
<td>6.9</td>
<td>0.41</td>
<td>66</td>
<td>3.9</td>
<td>600</td>
<td>1579</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>Col, colchicine.</p></fn><fn><label>b</label><p>Pac, paclitaxel.</p></fn><fn><label>c</label><p>Vbl, vinblastine.</p></fn><fn><label>d</label><p>IC50: concentration of drug inhibiting cell growth by 50%.</p></fn><fn><label>e</label><p>Paclitaxel-resistant CHO-TAX 5-6 cells.</p></fn><fn><label>f</label><p>Colchicine-and vinblastine-resistant CHO-VV 3-2 cells.</p></fn><fn><label>g</label><p>Multidrug-resistant leukemia CEM-VLB cells.</p></fn></table-wrap-foot></table-wrap> | {
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6,
0,
1,
2,
3,
4,
5,
6,
0,
1,
2,
3,
4,
5,
6,
0,
1,
2,
3,
4,
5,
6,
0,
1,
2,
3,
4,
5,
6,
0,
1,
2,
3,
4,
5,
6,
0,
1,
2,
3,
4,
5,
6,
0,
1,
2,
3,
4,
5,
6,
1,
2,
3,
4,
5,
6,
1,
2,
3,
4,
5,
6,
1,
2,
3,
4,
5,
6
]
} | {
"cell_index": [
"CA(1,0)",
"CA(1,1)",
"CA(1,2)",
"CA(1,3)",
"CA(1,4)",
"CA(1,5)",
"CA(1,6)",
"CA(2,0)",
"CA(2,1)",
"CA(2,2)",
"CA(2,3)",
"CA(2,4)",
"CA(2,5)",
"CA(2,6)",
"CA(3,0)",
"CA(3,1)",
"CA(3,2)",
"CA(3,3)",
"CA(3,4)",
"CA(3,5)",
"CA(3,6)",
"CA(4,0)",
"CA(4,1)",
"CA(4,2)",
"CA(4,3)",
"CA(4,4)",
"CA(4,5)",
"CA(4,6)",
"CA(5,0)",
"CA(5,1)",
"CA(5,2)",
"CA(5,3)",
"CA(5,4)",
"CA(5,5)",
"CA(5,6)",
"CA(6,0)",
"CA(6,1)",
"CA(6,2)",
"CA(6,3)",
"CA(6,4)",
"CA(6,5)",
"CA(6,6)",
"CA(7,0)",
"CA(7,1)",
"CA(7,2)",
"CA(7,3)",
"CA(7,4)",
"CA(7,5)",
"CA(7,6)",
"CA(8,0)",
"CA(8,1)",
"CA(8,2)",
"CA(8,3)",
"CA(8,4)",
"CA(8,5)",
"CA(8,6)",
"CA(9,0)",
"CA(9,1)",
"CA(9,2)",
"CA(9,3)",
"CA(9,4)",
"CA(9,5)",
"CA(9,6)",
"CA(10,0)",
"CA(10,1)",
"CA(10,2)",
"CA(10,3)",
"CA(10,4)",
"CA(10,5)",
"CA(10,6)",
"CA(11,1)",
"CA(11,2)",
"CA(11,3)",
"CA(11,4)",
"CA(11,5)",
"CA(11,6)",
"CA(12,1)",
"CA(12,2)",
"CA(12,3)",
"CA(12,4)",
"CA(12,5)",
"CA(12,6)",
"CA(13,1)",
"CA(13,2)",
"CA(13,3)",
"CA(13,4)",
"CA(13,5)",
"CA(13,6)"
],
"cell_record": [
"{\"value\": \"12\", \"type\": \"Other\"}",
"{\"value\": \"200\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"12\", \"unit\": \"nM\"}",
"{\"value\": \"0.83\", \"type\": \"Other\"}",
"{\"value\": \"250\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"12\", \"unit\": \"nM\"}",
"{\"value\": \"1.0\", \"type\": \"Other\"}",
"{\"value\": \"320\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"12\", \"unit\": \"nM\"}",
"{\"value\": \"1.3\", \"type\": \"Other\"}",
"{\"value\": \"26\", \"type\": \"Other\"}",
"{\"value\": \"14\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}",
"{\"value\": \"0.78\", \"type\": \"Other\"}",
"{\"value\": \"21\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"23\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"31\", \"type\": \"Other\"}",
"{\"value\": \"38\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"0.52\", \"type\": \"Other\"}",
"{\"value\": \"74\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"1.0\", \"type\": \"Other\"}",
"{\"value\": \"87\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}",
"{\"value\": \"1.3\", \"type\": \"Other\"}",
"{\"value\": \"35\", \"type\": \"Other\"}",
"{\"value\": \"12\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"0.38\", \"type\": \"Other\"}",
"{\"value\": \"39\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}",
"{\"value\": \"1.6\", \"type\": \"Other\"}",
"{\"value\": \"36\", \"type\": \"Other\"}",
"{\"value\": \"9.3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"0.52\", \"type\": \"Other\"}",
"{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"1.1\", \"type\": \"Other\"}",
"{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"38\", \"type\": \"Other\"}",
"{\"value\": \"8.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"0.52\", \"type\": \"Other\"}",
"{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}",
"{\"value\": \"1.1\", \"type\": \"Other\"}",
"{\"value\": \"44\", \"type\": \"Other\"}",
"{\"value\": \"5.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"0.71\", \"type\": \"Other\"}",
"{\"value\": \"15\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"2.1\", \"type\": \"Other\"}",
"{\"value\": \"9.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}",
"{\"value\": \"1.3\", \"type\": \"Other\"}",
"{\"value\": \"45\", \"type\": \"Other\"}",
"{\"value\": \"3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"0.41\", \"type\": \"Other\"}",
"{\"value\": \"8.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"1.1\", \"type\": \"Other\"}",
"{\"value\": \"9.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}",
"{\"value\": \"1.3\", \"type\": \"Other\"}",
"{\"value\": \"46\", \"type\": \"Other\"}",
"{\"value\": \"6.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"0.36\", \"type\": \"Other\"}",
"{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"60\", \"type\": \"Other\"}",
"{\"value\": \"86\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"0.37\", \"type\": \"Other\"}",
"{\"value\": \"260\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"1.1\", \"type\": \"Other\"}",
"{\"value\": \"270\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}",
"{\"value\": \"1.4\", \"type\": \"Other\"}",
"{\"value\": \"140\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"0.64\", \"type\": \"Other\"}",
"{\"value\": \"620\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"2.8\", \"type\": \"Other\"}",
"{\"value\": \"360\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}",
"{\"value\": \"46\", \"type\": \"Other\"}",
"{\"value\": \"520\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"3.1\", \"type\": \"Other\"}",
"{\"value\": \"140\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"0.82\", \"type\": \"Other\"}",
"{\"value\": \"3340\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}",
"{\"value\": \"12370\", \"type\": \"Other\"}",
"{\"value\": \"6.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"0.41\", \"type\": \"Other\"}",
"{\"value\": \"66\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"3.9\", \"type\": \"Other\"}",
"{\"value\": \"600\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}",
"{\"value\": \"1579\", \"type\": \"Other\"}"
]
} |
|
PMC3910272 | tbl3 | <table-wrap><label>Table 3</label><caption><title>IC50 Values (μM) for a Panel of Metallo-β-lactamasesa</title></caption><table><colgroup><col/><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>MBL</th>
<th>(S)-7d</th>
<th>(R)-7d</th>
<th>MBL</th>
<th>(S)-7d</th>
<th>(R)-7d</th>
</tr></thead><tbody>
<tr>
<td>SPM-1</td>
<td>23.2 ± 1.1</td>
<td>46.6 ± 1.1</td>
<td>VIM-2</td>
<td>54.7 ± 1.4</td>
<td>55.3 ± 1.3</td>
</tr>
<tr>
<td>IMP-1</td>
<td>75.6 ± 1.5</td>
<td>74.1 ± 1.6</td>
<td>Bc II</td>
<td>61.3 ± 1.3</td>
<td>132.4 ± 1.3</td>
</tr>
<tr>
<td>NDM-1</td>
<td>61.4 ± 1.3</td>
<td>47.1 ± 1.1</td>
<td> </td>
<td> </td>
<td> </td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>IC50 determinations were performed in duplicate over a range of 0.25–200 μM.</p></fn></table-wrap-foot></table-wrap> | {
"cell_value": [
"23.2",
"46.6",
"54.7",
"55.3",
"75.6",
"74.1",
"61.3",
"132.4",
"61.4",
"47.1"
],
"cell_raw": [
"23.2 ± 1.1",
"46.6 ± 1.1",
"54.7 ± 1.4",
"55.3 ± 1.3",
"75.6 ± 1.5",
"74.1 ± 1.6",
"61.3 ± 1.3",
"132.4 ± 1.3",
"61.4 ± 1.3",
"47.1 ± 1.1"
],
"cell_index": [
"CA(1,1)",
"CA(1,2)",
"CA(1,4)",
"CA(1,5)",
"CA(2,1)",
"CA(2,2)",
"CA(2,4)",
"CA(2,5)",
"CA(3,1)",
"CA(3,2)"
],
"cell_row_idx": [
1,
1,
1,
1,
2,
2,
2,
2,
3,
3
],
"cell_col_idx": [
1,
2,
4,
5,
1,
2,
4,
5,
1,
2
]
} | {
"cell_index": [
"CA(1,1)",
"CA(1,2)",
"CA(1,4)",
"CA(1,5)",
"CA(2,1)",
"CA(2,2)",
"CA(2,4)",
"CA(2,5)",
"CA(3,1)",
"CA(3,2)"
],
"cell_record": [
"{\"value\": \"23.2\", \"type\": \"IC50\", \"target\": \"SPM-1\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"46.6\", \"type\": \"IC50\", \"target\": \"SPM-1\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"54.7\", \"type\": \"IC50\", \"target\": \"VIM-2\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"55.3\", \"type\": \"IC50\", \"target\": \"VIM-2\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"75.6\", \"type\": \"IC50\", \"target\": \"IMP-1\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"74.1\", \"type\": \"IC50\", \"target\": \"IMP-1\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"61.3\", \"type\": \"IC50\", \"target\": \"Bc II\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"132.4\", \"type\": \"IC50\", \"target\": \"Bc II\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"61.4\", \"type\": \"IC50\", \"target\": \"NDM-1\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}",
"{\"value\": \"47.1\", \"type\": \"IC50\", \"target\": \"NDM-1\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}"
]
} |
|
PMC4018117 | tbl2 | <table-wrap><label>Table 2</label><caption><title>MRC and GI50 Values for the Substitutions of Indoline Aromatic Ring</title></caption><graphic></graphic><table><colgroup><col/><col/><col/><col/><col/><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>entry</th>
<th>compd</th>
<th>R1</th>
<th>R2</th>
<th>R3</th>
<th>R4</th>
<th>amox/clava,b</th>
<th>cefazolina,b</th>
<th>meropenema,c</th>
<th>GI50d</th>
</tr></thead><tbody>
<tr>
<td>1</td>
<td>1</td>
<td>H</td>
<td>Br</td>
<td>H</td>
<td>H</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>17.1</td>
</tr>
<tr>
<td>2</td>
<td>6a</td>
<td>H</td>
<td>Cl</td>
<td>H</td>
<td>H</td>
<td>8</td>
<td>4</td>
<td>8</td>
<td>35</td>
</tr>
<tr>
<td>3</td>
<td>6b</td>
<td>H</td>
<td>Me</td>
<td>H</td>
<td>H</td>
<td>16</td>
<td>16</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>4</td>
<td>6c</td>
<td>H</td>
<td>MeO</td>
<td>H</td>
<td>H</td>
<td>>32</td>
<td>>32</td>
<td>>32</td>
<td>–</td>
</tr>
<tr>
<td>5</td>
<td>6d</td>
<td>H</td>
<td>F</td>
<td>H</td>
<td>H</td>
<td>16</td>
<td>16</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>6</td>
<td>6e</td>
<td>H</td>
<td>H</td>
<td>H</td>
<td>H</td>
<td>16</td>
<td>16</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>7</td>
<td>6f</td>
<td>H</td>
<td>H</td>
<td colspan="2">phenylene</td>
<td>>32</td>
<td>>32</td>
<td>>32</td>
<td>–</td>
</tr>
<tr>
<td>8</td>
<td>6g</td>
<td>H</td>
<td>H</td>
<td>H</td>
<td>Br</td>
<td>>32</td>
<td>32</td>
<td>8</td>
<td>–</td>
</tr>
<tr>
<td>9</td>
<td>6h</td>
<td>H</td>
<td>H</td>
<td>Br</td>
<td>H</td>
<td>16</td>
<td>16</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>10</td>
<td>6i</td>
<td>Br</td>
<td>H</td>
<td>H</td>
<td>H</td>
<td>32</td>
<td>16</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>11</td>
<td>6j</td>
<td>H</td>
<td>Cl</td>
<td>H</td>
<td>F</td>
<td>16</td>
<td>16</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>12</td>
<td>6k</td>
<td>H</td>
<td>Cl</td>
<td>H</td>
<td>Cl</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>13.6</td>
</tr>
<tr>
<td>13</td>
<td>6l</td>
<td>H</td>
<td>Br</td>
<td>H</td>
<td>F</td>
<td>2</td>
<td>4</td>
<td>4</td>
<td>18.1</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>MRC values are in μg/mL.</p></fn><fn><label>b</label><p>MRSA ATCC BAA-44.</p></fn><fn><label>c</label><p>MRSA ATCC 33592.</p></fn><fn><label>d</label><p>HeLa cells; GI50 values are in μg/mL.</p></fn></table-wrap-foot></table-wrap> | {
"cell_value": [
"1",
"1",
"4",
"4",
"4",
"17.1",
"2",
"8",
"4",
"8",
"35",
"3",
"16",
"16",
"32",
"4",
"32",
"32",
"32",
"5",
"16",
"16",
"16",
"6",
"16",
"16",
"16",
"7",
"32",
"32",
"32",
"8",
"32",
"32",
"8",
"9",
"16",
"16",
"16",
"10",
"32",
"16",
"16",
"11",
"16",
"16",
"32",
"12",
"4",
"4",
"4",
"13.6",
"13",
"2",
"4",
"4",
"18.1"
],
"cell_raw": [
"1",
"1",
"4",
"4",
"4",
"17.1",
"2",
"8",
"4",
"8",
"35",
"3",
"16",
"16",
"32",
"4",
"32",
"32",
"32",
"5",
"16",
"16",
"16",
"6",
"16",
"16",
"16",
"7",
"32",
"32",
"32",
"8",
"32",
"32",
"8",
"9",
"16",
"16",
"16",
"10",
"32",
"16",
"16",
"11",
"16",
"16",
"32",
"12",
"4",
"4",
"4",
"13.6",
"13",
"2",
"4",
"4",
"18.1"
],
"cell_index": [
"CA(1,0)",
"CA(1,1)",
"CA(1,6)",
"CA(1,7)",
"CA(1,8)",
"CA(1,9)",
"CA(2,0)",
"CA(2,6)",
"CA(2,7)",
"CA(2,8)",
"CA(2,9)",
"CA(3,0)",
"CA(3,6)",
"CA(3,7)",
"CA(3,8)",
"CA(4,0)",
"CA(4,6)",
"CA(4,7)",
"CA(4,8)",
"CA(5,0)",
"CA(5,6)",
"CA(5,7)",
"CA(5,8)",
"CA(6,0)",
"CA(6,6)",
"CA(6,7)",
"CA(6,8)",
"CA(7,0)",
"CA(7,6)",
"CA(7,7)",
"CA(7,8)",
"CA(8,0)",
"CA(8,6)",
"CA(8,7)",
"CA(8,8)",
"CA(9,0)",
"CA(9,6)",
"CA(9,7)",
"CA(9,8)",
"CA(10,0)",
"CA(10,6)",
"CA(10,7)",
"CA(10,8)",
"CA(11,0)",
"CA(11,6)",
"CA(11,7)",
"CA(11,8)",
"CA(12,0)",
"CA(12,6)",
"CA(12,7)",
"CA(12,8)",
"CA(12,9)",
"CA(13,0)",
"CA(13,6)",
"CA(13,7)",
"CA(13,8)",
"CA(13,9)"
],
"cell_row_idx": [
1,
1,
1,
1,
1,
1,
2,
2,
2,
2,
2,
3,
3,
3,
3,
4,
4,
4,
4,
5,
5,
5,
5,
6,
6,
6,
6,
7,
7,
7,
7,
8,
8,
8,
8,
9,
9,
9,
9,
10,
10,
10,
10,
11,
11,
11,
11,
12,
12,
12,
12,
12,
13,
13,
13,
13,
13
],
"cell_col_idx": [
0,
1,
6,
7,
8,
9,
0,
6,
7,
8,
9,
0,
6,
7,
8,
0,
6,
7,
8,
0,
6,
7,
8,
0,
6,
7,
8,
0,
6,
7,
8,
0,
6,
7,
8,
0,
6,
7,
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} |
|
PMC4018117 | tbl3 | <table-wrap><label>Table 3</label><caption><title>MRC and GI50 Values for 1 Analogues with Modifications on the Side Chain</title></caption><graphic></graphic><table><colgroup><col/><col/><col/><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>entry</th>
<th>compd</th>
<th>R1</th>
<th>R2</th>
<th>amox/clava,b</th>
<th>cefazolina,b</th>
<th>meropenema,c</th>
<th>GI50d</th>
</tr></thead><tbody>
<tr>
<td>1</td>
<td>1</td>
<td>H</td>
<td>SO2PhpCl</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>17.1</td>
</tr>
<tr>
<td>2</td>
<td>11a</td>
<td>H</td>
<td>H</td>
<td>32</td>
<td>32</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>3</td>
<td>11b</td>
<td>F</td>
<td>H</td>
<td>>32</td>
<td>32</td>
<td>16</td>
<td>16.2</td>
</tr>
<tr>
<td>4</td>
<td>12a</td>
<td>H</td>
<td>TFA</td>
<td>>32</td>
<td>>32</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>5</td>
<td>12b</td>
<td>H</td>
<td>COBu</td>
<td>>32</td>
<td>>32</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>6</td>
<td>12c</td>
<td>H</td>
<td>COPhpCl</td>
<td>>32</td>
<td>>32</td>
<td>>32</td>
<td>–</td>
</tr>
<tr>
<td>7</td>
<td>12d</td>
<td>H</td>
<td>SO2Ph</td>
<td>8</td>
<td>8</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>8</td>
<td>12e</td>
<td>H</td>
<td>SO2PhpMe</td>
<td>>32</td>
<td>>32</td>
<td>>32</td>
<td>–</td>
</tr>
<tr>
<td>9</td>
<td>12f</td>
<td>H</td>
<td>SO2PhpF</td>
<td>>32</td>
<td>>32</td>
<td>>32</td>
<td>–</td>
</tr>
<tr>
<td>10</td>
<td>12g</td>
<td>H</td>
<td>SO2PhpBr</td>
<td>4</td>
<td>4</td>
<td>8</td>
<td>40</td>
</tr>
<tr>
<td>11</td>
<td>12h</td>
<td>H</td>
<td>SO2PhpI</td>
<td>4</td>
<td>4</td>
<td>32</td>
<td>33</td>
</tr>
<tr>
<td>12</td>
<td>12i</td>
<td>H</td>
<td>SO2Ph3,4Cl</td>
<td>4</td>
<td>2</td>
<td>4</td>
<td>12.8</td>
</tr>
<tr>
<td>13</td>
<td>12j</td>
<td>H</td>
<td>SO2Ph2,4Cl</td>
<td>8</td>
<td>>32</td>
<td>4</td>
<td>–</td>
</tr>
<tr>
<td>14</td>
<td>12k</td>
<td>H</td>
<td>SO2PhpCN</td>
<td>16</td>
<td>8</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>15</td>
<td>12l</td>
<td>H</td>
<td>SO2PhpNHAc</td>
<td>>32</td>
<td>>32</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>16</td>
<td>12m</td>
<td>H</td>
<td>SO25Py</td>
<td>32</td>
<td>32</td>
<td>32</td>
<td>–</td>
</tr>
<tr>
<td>17</td>
<td>12n</td>
<td>H</td>
<td>SO2PhpNO2</td>
<td>>32</td>
<td>>32</td>
<td>>32</td>
<td>–</td>
</tr>
<tr>
<td>18</td>
<td>12o</td>
<td>H</td>
<td>SO2PhpNH2</td>
<td>16</td>
<td>16</td>
<td>16</td>
<td>–</td>
</tr>
<tr>
<td>20</td>
<td>13a</td>
<td>F</td>
<td>SO2PhpOMe</td>
<td>8</td>
<td>4</td>
<td>8</td>
<td>49</td>
</tr>
<tr>
<td>21</td>
<td>13b</td>
<td>F</td>
<td>SO2PhpMe</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>22</td>
</tr>
<tr>
<td>22</td>
<td>13c</td>
<td>F</td>
<td>SO2PhpF</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>18.3</td>
</tr>
<tr>
<td>23</td>
<td>6l</td>
<td>F</td>
<td>SO2PhpCl</td>
<td>2</td>
<td>4</td>
<td>4</td>
<td>18.1</td>
</tr>
<tr>
<td>24</td>
<td>13d</td>
<td>F</td>
<td>SO2PhpBr</td>
<td>1</td>
<td>1</td>
<td>1</td>
<td>22</td>
</tr>
<tr>
<td>25</td>
<td>13e</td>
<td>F</td>
<td>SO2PhpI</td>
<td>4</td>
<td>2</td>
<td>4</td>
<td>19.6</td>
</tr>
<tr>
<td>26</td>
<td>13f</td>
<td>F</td>
<td>SO2Ph3,4Cl</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>31</td>
</tr>
<tr>
<td>27</td>
<td>13g</td>
<td>F</td>
<td>SO2PhpNHAc</td>
<td>32</td>
<td>32</td>
<td>16</td>
<td>32</td>
</tr>
<tr>
<td>28</td>
<td>13h</td>
<td>F</td>
<td>SO2PhpCN</td>
<td>8</td>
<td>4</td>
<td>4</td>
<td>17.0</td>
</tr>
<tr>
<td>29</td>
<td>13i</td>
<td>F</td>
<td>SO2PhpCF3</td>
<td>4</td>
<td>4</td>
<td>4</td>
<td>8.7</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>MRC values are in μg/mL.</p></fn><fn><label>b</label><p>MRSA ATCC BAA-44.</p></fn><fn><label>c</label><p>MRSA ATCC 33592.</p></fn><fn><label>d</label><p>HeLa cells; GI50 values are in μg/mL.</p></fn></table-wrap-foot></table-wrap> | {
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"CA(4,0)",
"CA(4,4)",
"CA(4,5)",
"CA(4,6)",
"CA(5,0)",
"CA(5,4)",
"CA(5,5)",
"CA(5,6)",
"CA(6,0)",
"CA(6,4)",
"CA(6,5)",
"CA(6,6)",
"CA(7,0)",
"CA(7,4)",
"CA(7,5)",
"CA(7,6)",
"CA(8,0)",
"CA(8,4)",
"CA(8,5)",
"CA(8,6)",
"CA(9,0)",
"CA(9,4)",
"CA(9,5)",
"CA(9,6)",
"CA(10,0)",
"CA(10,4)",
"CA(10,5)",
"CA(10,6)",
"CA(10,7)",
"CA(11,0)",
"CA(11,4)",
"CA(11,5)",
"CA(11,6)",
"CA(11,7)",
"CA(12,0)",
"CA(12,4)",
"CA(12,5)",
"CA(12,6)",
"CA(12,7)",
"CA(13,0)",
"CA(13,4)",
"CA(13,5)",
"CA(13,6)",
"CA(14,0)",
"CA(14,4)",
"CA(14,5)",
"CA(14,6)",
"CA(15,0)",
"CA(15,4)",
"CA(15,5)",
"CA(15,6)",
"CA(16,0)",
"CA(16,4)",
"CA(16,5)",
"CA(16,6)",
"CA(17,0)",
"CA(17,4)",
"CA(17,5)",
"CA(17,6)",
"CA(18,0)",
"CA(18,4)",
"CA(18,5)",
"CA(18,6)",
"CA(19,0)",
"CA(19,4)",
"CA(19,5)",
"CA(19,6)",
"CA(19,7)",
"CA(20,0)",
"CA(20,4)",
"CA(20,5)",
"CA(20,6)",
"CA(20,7)",
"CA(21,0)",
"CA(21,4)",
"CA(21,5)",
"CA(21,6)",
"CA(21,7)",
"CA(22,0)",
"CA(22,4)",
"CA(22,5)",
"CA(22,6)",
"CA(22,7)",
"CA(23,0)",
"CA(23,4)",
"CA(23,5)",
"CA(23,6)",
"CA(23,7)",
"CA(24,0)",
"CA(24,4)",
"CA(24,5)",
"CA(24,6)",
"CA(24,7)",
"CA(25,0)",
"CA(25,4)",
"CA(25,5)",
"CA(25,6)",
"CA(25,7)",
"CA(26,0)",
"CA(26,4)",
"CA(26,5)",
"CA(26,6)",
"CA(26,7)",
"CA(27,0)",
"CA(27,4)",
"CA(27,5)",
"CA(27,6)",
"CA(27,7)",
"CA(28,0)",
"CA(28,4)",
"CA(28,5)",
"CA(28,6)",
"CA(28,7)"
],
"cell_record": [
"{\"value\": \"1\", \"type\": \"Other\"}",
"{\"value\": \"1\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"17.1\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"1\", \"unit\": \"xx\"}",
"{\"value\": \"2\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"3\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"16.2\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"11b\", \"unit\": \"xx\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"7\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"9\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"10\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"40\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"12g\", \"unit\": \"xx\"}",
"{\"value\": \"11\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"33\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"12h\", \"unit\": \"xx\"}",
"{\"value\": \"12\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"2\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"12.8\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"12i\", \"unit\": \"xx\"}",
"{\"value\": \"13\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"14\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"15\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"17\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"18\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"20\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"49\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13a\", \"unit\": \"xx\"}",
"{\"value\": \"21\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"22\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13b\", \"unit\": \"xx\"}",
"{\"value\": \"22\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"18.3\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13c\", \"unit\": \"xx\"}",
"{\"value\": \"23\", \"type\": \"Other\"}",
"{\"value\": \"2\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"18.1\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"6l\", \"unit\": \"xx\"}",
"{\"value\": \"24\", \"type\": \"Other\"}",
"{\"value\": \"1\", \"type\": \"Other\"}",
"{\"value\": \"1\", \"type\": \"Other\"}",
"{\"value\": \"1\", \"type\": \"Other\"}",
"{\"value\": \"22\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13d\", \"unit\": \"xx\"}",
"{\"value\": \"25\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"2\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"19.6\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13e\", \"unit\": \"xx\"}",
"{\"value\": \"26\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"31\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13f\", \"unit\": \"xx\"}",
"{\"value\": \"27\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"Other\"}",
"{\"value\": \"16\", \"type\": \"Other\"}",
"{\"value\": \"32\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13g\", \"unit\": \"xx\"}",
"{\"value\": \"28\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"17.0\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13h\", \"unit\": \"xx\"}",
"{\"value\": \"29\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"8.7\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13i\", \"unit\": \"xx\"}"
]
} |
|
PMC4106271 | tbl3 | <table-wrap><label>Table 3</label><caption><title>Efficiency and Potency of Further Characterized Piperine Derivatives and Piperinea</title></caption><table><colgroup><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>compd</th>
<th>IGABA-max (%)</th>
<th>EC50 (μM)</th>
<th>nH</th>
<th>n</th>
</tr></thead><tbody>
<tr>
<td>piperine</td>
<td>302 ± 27</td>
<td>52.4 ± 9.3</td>
<td>1.5 ± 0.2</td>
<td>3</td>
</tr>
<tr>
<td>22</td>
<td>1581 ± 74**</td>
<td>86.7 ± 13.9</td>
<td>2.3 ± 0.2</td>
<td>6</td>
</tr>
<tr>
<td>23</td>
<td>1673 ± 146**</td>
<td>51.7 ± 9.5</td>
<td>3.1 ± 0.8</td>
<td>6</td>
</tr>
<tr>
<td>25</td>
<td>760 ± 47**</td>
<td>13.8 ± 1.8**</td>
<td>1.8 ± 0.1</td>
<td>6</td>
</tr>
<tr>
<td>35</td>
<td>733 ± 60**</td>
<td>67.7 ± 11.0</td>
<td>1.9 ± 0.3</td>
<td>6</td>
</tr>
<tr>
<td>43</td>
<td>505 ± 24**</td>
<td>23.1 ± 3.3*</td>
<td>1.6 ± 0.2</td>
<td>6</td>
</tr>
<tr>
<td>47</td>
<td>603 ± 87*</td>
<td>70.8 ± 21.1</td>
<td>1.2 ± 0.2</td>
<td>3</td>
</tr>
<tr>
<td>53</td>
<td>388 ± 64</td>
<td>55.3 ± 17.6</td>
<td>1.5 ± 0.2</td>
<td>3</td>
</tr>
<tr>
<td>56</td>
<td>165 ± 4**</td>
<td>36.8 ± 2.0</td>
<td>1.2 ± 0.0</td>
<td>3</td>
</tr>
<tr>
<td>72</td>
<td>706 ± 58**</td>
<td>102.0 ± 11.2</td>
<td>1.9 ± 0.2</td>
<td>5</td>
</tr>
<tr>
<td>73</td>
<td>480 ± 85</td>
<td>31.8 ± 5.3</td>
<td>2.7 ± 0.2</td>
<td>6</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>From ref (31), including number of experiments n. Asterisks indicate significant differences from piperine: *p < 0.05; **p < 0.01.</p></fn></table-wrap-foot></table-wrap> | {
"cell_value": [
"302",
"52.4",
"1.5",
"3",
"22",
"1581",
"86.7",
"2.3",
"6",
"23",
"1673",
"51.7",
"3.1",
"6",
"25",
"760",
"13.8",
"1.8",
"6",
"35",
"733",
"67.7",
"1.9",
"6",
"43",
"505",
"23.1",
"1.6",
"6",
"47",
"603",
"70.8",
"1.2",
"3",
"53",
"388",
"55.3",
"1.5",
"3",
"56",
"165",
"36.8",
"1.2",
"3",
"72",
"706",
"102.0",
"1.9",
"5",
"73",
"480",
"31.8",
"2.7",
"6"
],
"cell_raw": [
"302 ± 27",
"52.4 ± 9.3",
"1.5 ± 0.2",
"3",
"22",
"1581 ± 74**",
"86.7 ± 13.9",
"2.3 ± 0.2",
"6",
"23",
"1673 ± 146**",
"51.7 ± 9.5",
"3.1 ± 0.8",
"6",
"25",
"760 ± 47**",
"13.8 ± 1.8**",
"1.8 ± 0.1",
"6",
"35",
"733 ± 60**",
"67.7 ± 11.0",
"1.9 ± 0.3",
"6",
"43",
"505 ± 24**",
"23.1 ± 3.3*",
"1.6 ± 0.2",
"6",
"47",
"603 ± 87*",
"70.8 ± 21.1",
"1.2 ± 0.2",
"3",
"53",
"388 ± 64",
"55.3 ± 17.6",
"1.5 ± 0.2",
"3",
"56",
"165 ± 4**",
"36.8 ± 2.0",
"1.2 ± 0.0",
"3",
"72",
"706 ± 58**",
"102.0 ± 11.2",
"1.9 ± 0.2",
"5",
"73",
"480 ± 85",
"31.8 ± 5.3",
"2.7 ± 0.2",
"6"
],
"cell_index": [
"CA(1,1)",
"CA(1,2)",
"CA(1,3)",
"CA(1,4)",
"CA(2,0)",
"CA(2,1)",
"CA(2,2)",
"CA(2,3)",
"CA(2,4)",
"CA(3,0)",
"CA(3,1)",
"CA(3,2)",
"CA(3,3)",
"CA(3,4)",
"CA(4,0)",
"CA(4,1)",
"CA(4,2)",
"CA(4,3)",
"CA(4,4)",
"CA(5,0)",
"CA(5,1)",
"CA(5,2)",
"CA(5,3)",
"CA(5,4)",
"CA(6,0)",
"CA(6,1)",
"CA(6,2)",
"CA(6,3)",
"CA(6,4)",
"CA(7,0)",
"CA(7,1)",
"CA(7,2)",
"CA(7,3)",
"CA(7,4)",
"CA(8,0)",
"CA(8,1)",
"CA(8,2)",
"CA(8,3)",
"CA(8,4)",
"CA(9,0)",
"CA(9,1)",
"CA(9,2)",
"CA(9,3)",
"CA(9,4)",
"CA(10,0)",
"CA(10,1)",
"CA(10,2)",
"CA(10,3)",
"CA(10,4)",
"CA(11,0)",
"CA(11,1)",
"CA(11,2)",
"CA(11,3)",
"CA(11,4)"
],
"cell_row_idx": [
1,
1,
1,
1,
2,
2,
2,
2,
2,
3,
3,
3,
3,
3,
4,
4,
4,
4,
4,
5,
5,
5,
5,
5,
6,
6,
6,
6,
6,
7,
7,
7,
7,
7,
8,
8,
8,
8,
8,
9,
9,
9,
9,
9,
10,
10,
10,
10,
10,
11,
11,
11,
11,
11
],
"cell_col_idx": [
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4,
0,
1,
2,
3,
4
]
} | {
"cell_index": [
"CA(1,1)",
"CA(1,2)",
"CA(1,3)",
"CA(1,4)",
"CA(2,0)",
"CA(2,1)",
"CA(2,2)",
"CA(2,3)",
"CA(2,4)",
"CA(3,0)",
"CA(3,1)",
"CA(3,2)",
"CA(3,3)",
"CA(3,4)",
"CA(4,0)",
"CA(4,1)",
"CA(4,2)",
"CA(4,3)",
"CA(4,4)",
"CA(5,0)",
"CA(5,1)",
"CA(5,2)",
"CA(5,3)",
"CA(5,4)",
"CA(6,0)",
"CA(6,1)",
"CA(6,2)",
"CA(6,3)",
"CA(6,4)",
"CA(7,0)",
"CA(7,1)",
"CA(7,2)",
"CA(7,3)",
"CA(7,4)",
"CA(8,0)",
"CA(8,1)",
"CA(8,2)",
"CA(8,3)",
"CA(8,4)",
"CA(9,0)",
"CA(9,1)",
"CA(9,2)",
"CA(9,3)",
"CA(9,4)",
"CA(10,0)",
"CA(10,1)",
"CA(10,2)",
"CA(10,3)",
"CA(10,4)",
"CA(11,0)",
"CA(11,1)",
"CA(11,2)",
"CA(11,3)",
"CA(11,4)"
],
"cell_record": [
"{\"value\": \"302\", \"type\": \"Other\"}",
"{\"value\": \"52.4\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"piperine\", \"unit\": \"μM\"}",
"{\"value\": \"1.5\", \"type\": \"Other\"}",
"{\"value\": \"3\", \"type\": \"Other\"}",
"{\"value\": \"22\", \"type\": \"Other\"}",
"{\"value\": \"1581\", \"type\": \"Other\"}",
"{\"value\": \"86.7\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"22\", \"unit\": \"μM\"}",
"{\"value\": \"2.3\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"23\", \"type\": \"Other\"}",
"{\"value\": \"1673\", \"type\": \"Other\"}",
"{\"value\": \"51.7\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"23\", \"unit\": \"μM\"}",
"{\"value\": \"3.1\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"25\", \"type\": \"Other\"}",
"{\"value\": \"760\", \"type\": \"Other\"}",
"{\"value\": \"13.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"25\", \"unit\": \"μM\"}",
"{\"value\": \"1.8\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"35\", \"type\": \"Other\"}",
"{\"value\": \"733\", \"type\": \"Other\"}",
"{\"value\": \"67.7\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"μM\"}",
"{\"value\": \"1.9\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"43\", \"type\": \"Other\"}",
"{\"value\": \"505\", \"type\": \"Other\"}",
"{\"value\": \"23.1\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"43\", \"unit\": \"μM\"}",
"{\"value\": \"1.6\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"47\", \"type\": \"Other\"}",
"{\"value\": \"603\", \"type\": \"Other\"}",
"{\"value\": \"70.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"47\", \"unit\": \"μM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"3\", \"type\": \"Other\"}",
"{\"value\": \"53\", \"type\": \"Other\"}",
"{\"value\": \"388\", \"type\": \"Other\"}",
"{\"value\": \"55.3\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"53\", \"unit\": \"μM\"}",
"{\"value\": \"1.5\", \"type\": \"Other\"}",
"{\"value\": \"3\", \"type\": \"Other\"}",
"{\"value\": \"56\", \"type\": \"Other\"}",
"{\"value\": \"165\", \"type\": \"Other\"}",
"{\"value\": \"36.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"56\", \"unit\": \"μM\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"3\", \"type\": \"Other\"}",
"{\"value\": \"72\", \"type\": \"Other\"}",
"{\"value\": \"706\", \"type\": \"Other\"}",
"{\"value\": \"102.0\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"72\", \"unit\": \"μM\"}",
"{\"value\": \"1.9\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}",
"{\"value\": \"73\", \"type\": \"Other\"}",
"{\"value\": \"480\", \"type\": \"Other\"}",
"{\"value\": \"31.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"73\", \"unit\": \"μM\"}",
"{\"value\": \"2.7\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}"
]
} |
|
PMC4106271 | tbl4 | <table-wrap><label>Table 4</label><caption><title>Efficiency and Potency of 23 and 25 on GABAA Receptors of Different Subunit Compositionsa</title></caption><table><colgroup><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>receptor subtype</th>
<th>IGABA,max (%)</th>
<th>EC50 (μM)</th>
<th>nH</th>
<th>n</th>
</tr></thead><tbody>
<tr>
<td colspan="5">Compound 23</td>
</tr>
<tr>
<td>α1β1γ2S</td>
<td>1157 ± 69*</td>
<td>57.5 ± 7.3</td>
<td>1.8 ± 0.1</td>
<td>5</td>
</tr>
<tr>
<td>α1β2γ2S</td>
<td>1673 ± 146</td>
<td>51.7 ± 9.5</td>
<td>3.1 ± 0.8</td>
<td>6</td>
</tr>
<tr>
<td>α1β3γ2S</td>
<td>1240 ± 128</td>
<td>34.7 ± 5.7</td>
<td>1.9 ± 0.2</td>
<td>5</td>
</tr>
<tr>
<td>α2β2γ2S</td>
<td>980 ± 129**</td>
<td>26.4 ± 6.6</td>
<td>1.9 ± 0.4</td>
<td>6</td>
</tr>
<tr>
<td>α3β2γ2S</td>
<td>1285 ± 142</td>
<td>36.6 ± 7.2</td>
<td>1.9 ± 0.3</td>
<td>5</td>
</tr>
<tr>
<td>α4β2γ2S</td>
<td>1316 ± 55*</td>
<td>34.7 ± 3.8</td>
<td>1.7 ± 0.1</td>
<td>7</td>
</tr>
<tr>
<td>α5β2γ2S</td>
<td>1624 ± 156</td>
<td>61.9 ± 10.4</td>
<td>1.4 ± 0.1</td>
<td>7</td>
</tr>
<tr>
<td colspan="5">Compound 25</td>
</tr>
<tr>
<td>α1β1γ2S</td>
<td>152 ± 30**</td>
<td>15.9 ± 4.9</td>
<td>1.3 ± 0.6</td>
<td>5</td>
</tr>
<tr>
<td>α1β2γ2S</td>
<td>760 ± 47</td>
<td>13.8 ± 1.8</td>
<td>1.8 ± 0.1</td>
<td>8</td>
</tr>
<tr>
<td>α1β3γ2S</td>
<td>587 ± 8**</td>
<td>29.5 ± 2.9**</td>
<td>1.5 ± 0.1</td>
<td>4</td>
</tr>
<tr>
<td>α2β2γ2S</td>
<td>512 ± 26**</td>
<td>14.8 ± 1.9</td>
<td>2.2 ± 0.3</td>
<td>4</td>
</tr>
<tr>
<td>α3β2γ2S</td>
<td>617 ± 42*</td>
<td>16.0 ± 2.7</td>
<td>1.8 ± 0.1</td>
<td>6</td>
</tr>
<tr>
<td>α4β2γ2S</td>
<td>419 ± 73**</td>
<td>56.7 ± 21.0</td>
<td>1.3 ± 0.3</td>
<td>4</td>
</tr>
<tr>
<td>α5β2γ2S</td>
<td>387 ± 20**</td>
<td>17.2 ± 1.4</td>
<td>1.7 ± 0.2</td>
<td>5</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>Asterisks indicate significant differences from α1β2γ2S receptor subtype as follows: *p < 0.05; **p < 0.01.</p></fn></table-wrap-foot></table-wrap> | {
"cell_value": [
"1157",
"57.5",
"1.8",
"5",
"1673",
"51.7",
"3.1",
"6",
"1240",
"34.7",
"1.9",
"5",
"980",
"26.4",
"1.9",
"6",
"1285",
"36.6",
"1.9",
"5",
"1316",
"34.7",
"1.7",
"7",
"1624",
"61.9",
"1.4",
"7",
"152",
"15.9",
"1.3",
"5",
"760",
"13.8",
"1.8",
"8",
"587",
"29.5",
"1.5",
"4",
"512",
"14.8",
"2.2",
"4",
"617",
"16.0",
"1.8",
"6",
"419",
"56.7",
"1.3",
"4",
"387",
"17.2",
"1.7",
"5"
],
"cell_raw": [
"1157 ± 69*",
"57.5 ± 7.3",
"1.8 ± 0.1",
"5",
"1673 ± 146",
"51.7 ± 9.5",
"3.1 ± 0.8",
"6",
"1240 ± 128",
"34.7 ± 5.7",
"1.9 ± 0.2",
"5",
"980 ± 129**",
"26.4 ± 6.6",
"1.9 ± 0.4",
"6",
"1285 ± 142",
"36.6 ± 7.2",
"1.9 ± 0.3",
"5",
"1316 ± 55*",
"34.7 ± 3.8",
"1.7 ± 0.1",
"7",
"1624 ± 156",
"61.9 ± 10.4",
"1.4 ± 0.1",
"7",
"152 ± 30**",
"15.9 ± 4.9",
"1.3 ± 0.6",
"5",
"760 ± 47",
"13.8 ± 1.8",
"1.8 ± 0.1",
"8",
"587 ± 8**",
"29.5 ± 2.9**",
"1.5 ± 0.1",
"4",
"512 ± 26**",
"14.8 ± 1.9",
"2.2 ± 0.3",
"4",
"617 ± 42*",
"16.0 ± 2.7",
"1.8 ± 0.1",
"6",
"419 ± 73**",
"56.7 ± 21.0",
"1.3 ± 0.3",
"4",
"387 ± 20**",
"17.2 ± 1.4",
"1.7 ± 0.2",
"5"
],
"cell_index": [
"CA(2,1)",
"CA(2,2)",
"CA(2,3)",
"CA(2,4)",
"CA(3,1)",
"CA(3,2)",
"CA(3,3)",
"CA(3,4)",
"CA(4,1)",
"CA(4,2)",
"CA(4,3)",
"CA(4,4)",
"CA(5,1)",
"CA(5,2)",
"CA(5,3)",
"CA(5,4)",
"CA(6,1)",
"CA(6,2)",
"CA(6,3)",
"CA(6,4)",
"CA(7,1)",
"CA(7,2)",
"CA(7,3)",
"CA(7,4)",
"CA(8,1)",
"CA(8,2)",
"CA(8,3)",
"CA(8,4)",
"CA(10,1)",
"CA(10,2)",
"CA(10,3)",
"CA(10,4)",
"CA(11,1)",
"CA(11,2)",
"CA(11,3)",
"CA(11,4)",
"CA(12,1)",
"CA(12,2)",
"CA(12,3)",
"CA(12,4)",
"CA(13,1)",
"CA(13,2)",
"CA(13,3)",
"CA(13,4)",
"CA(14,1)",
"CA(14,2)",
"CA(14,3)",
"CA(14,4)",
"CA(15,1)",
"CA(15,2)",
"CA(15,3)",
"CA(15,4)",
"CA(16,1)",
"CA(16,2)",
"CA(16,3)",
"CA(16,4)"
],
"cell_row_idx": [
2,
2,
2,
2,
3,
3,
3,
3,
4,
4,
4,
4,
5,
5,
5,
5,
6,
6,
6,
6,
7,
7,
7,
7,
8,
8,
8,
8,
10,
10,
10,
10,
11,
11,
11,
11,
12,
12,
12,
12,
13,
13,
13,
13,
14,
14,
14,
14,
15,
15,
15,
15,
16,
16,
16,
16
],
"cell_col_idx": [
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4,
1,
2,
3,
4
]
} | {
"cell_index": [
"CA(2,1)",
"CA(2,2)",
"CA(2,3)",
"CA(2,4)",
"CA(3,1)",
"CA(3,2)",
"CA(3,3)",
"CA(3,4)",
"CA(4,1)",
"CA(4,2)",
"CA(4,3)",
"CA(4,4)",
"CA(5,1)",
"CA(5,2)",
"CA(5,3)",
"CA(5,4)",
"CA(6,1)",
"CA(6,2)",
"CA(6,3)",
"CA(6,4)",
"CA(7,1)",
"CA(7,2)",
"CA(7,3)",
"CA(7,4)",
"CA(8,1)",
"CA(8,2)",
"CA(8,3)",
"CA(8,4)",
"CA(10,1)",
"CA(10,2)",
"CA(10,3)",
"CA(10,4)",
"CA(11,1)",
"CA(11,2)",
"CA(11,3)",
"CA(11,4)",
"CA(12,1)",
"CA(12,2)",
"CA(12,3)",
"CA(12,4)",
"CA(13,1)",
"CA(13,2)",
"CA(13,3)",
"CA(13,4)",
"CA(14,1)",
"CA(14,2)",
"CA(14,3)",
"CA(14,4)",
"CA(15,1)",
"CA(15,2)",
"CA(15,3)",
"CA(15,4)",
"CA(16,1)",
"CA(16,2)",
"CA(16,3)",
"CA(16,4)"
],
"cell_record": [
"{\"value\": \"1157\", \"type\": \"Other\"}",
"{\"value\": \"57.5\", \"type\": \"EC50\", \"target\": \"α1β1γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"1.8\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}",
"{\"value\": \"1673\", \"type\": \"Other\"}",
"{\"value\": \"51.7\", \"type\": \"EC50\", \"target\": \"α1β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"3.1\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"1240\", \"type\": \"Other\"}",
"{\"value\": \"34.7\", \"type\": \"EC50\", \"target\": \"α1β3γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"1.9\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}",
"{\"value\": \"980\", \"type\": \"Other\"}",
"{\"value\": \"26.4\", \"type\": \"EC50\", \"target\": \"α2β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"1.9\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"1285\", \"type\": \"Other\"}",
"{\"value\": \"36.6\", \"type\": \"EC50\", \"target\": \"α3β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"1.9\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}",
"{\"value\": \"1316\", \"type\": \"Other\"}",
"{\"value\": \"34.7\", \"type\": \"EC50\", \"target\": \"α4β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"1.7\", \"type\": \"Other\"}",
"{\"value\": \"7\", \"type\": \"Other\"}",
"{\"value\": \"1624\", \"type\": \"Other\"}",
"{\"value\": \"61.9\", \"type\": \"EC50\", \"target\": \"α5β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}",
"{\"value\": \"1.4\", \"type\": \"Other\"}",
"{\"value\": \"7\", \"type\": \"Other\"}",
"{\"value\": \"152\", \"type\": \"Other\"}",
"{\"value\": \"15.9\", \"type\": \"EC50\", \"target\": \"α1β1γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"1.3\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}",
"{\"value\": \"760\", \"type\": \"Other\"}",
"{\"value\": \"13.8\", \"type\": \"EC50\", \"target\": \"α1β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"1.8\", \"type\": \"Other\"}",
"{\"value\": \"8\", \"type\": \"Other\"}",
"{\"value\": \"587\", \"type\": \"Other\"}",
"{\"value\": \"29.5\", \"type\": \"EC50\", \"target\": \"α1β3γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"1.5\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"512\", \"type\": \"Other\"}",
"{\"value\": \"14.8\", \"type\": \"EC50\", \"target\": \"α2β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"2.2\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"617\", \"type\": \"Other\"}",
"{\"value\": \"16.0\", \"type\": \"EC50\", \"target\": \"α3β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"1.8\", \"type\": \"Other\"}",
"{\"value\": \"6\", \"type\": \"Other\"}",
"{\"value\": \"419\", \"type\": \"Other\"}",
"{\"value\": \"56.7\", \"type\": \"EC50\", \"target\": \"α4β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"1.3\", \"type\": \"Other\"}",
"{\"value\": \"4\", \"type\": \"Other\"}",
"{\"value\": \"387\", \"type\": \"Other\"}",
"{\"value\": \"17.2\", \"type\": \"EC50\", \"target\": \"α5β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}",
"{\"value\": \"1.7\", \"type\": \"Other\"}",
"{\"value\": \"5\", \"type\": \"Other\"}"
]
} |
|
PMC4203399 | tbl1 | <table-wrap><label>Table 1</label><caption><title>Biological Activities of the Target Pyrazolobenzothiazines 2a–u, 3, 4, and 5</title></caption><graphic></graphic><table><colgroup><col/><col/><col/><col/><col/><col/><col/></colgroup><thead>
<tr>
<th> </th>
<th> </th>
<th> </th>
<th colspan="4">cell-based replicon assay<hr/></th>
</tr>
<tr>
<th>compd</th>
<th>R</th>
<th>anti-NS5B assay, IC50 a (μM)</th>
<th>EC50 b (μM)</th>
<th>EC90 c (μM)</th>
<th>CC50 d (μM)</th>
<th>SI e</th>
</tr></thead><tbody>
<tr>
<td>2a</td>
<td>(3-Cl)Ph</td>
<td>4.3 ± 0.2</td>
<td>9.8 ± 3.2</td>
<td>41 ± 11</td>
<td>>179</td>
<td>>18</td>
</tr>
<tr>
<td>2b</td>
<td>(4-Cl)Ph</td>
<td>7.9 ± 0.3</td>
<td>8.1 ± 4.3</td>
<td>23.3 ± 11.4</td>
<td>>224</td>
<td>>28</td>
</tr>
<tr>
<td>2c</td>
<td>(2-Cl)Ph</td>
<td>17.8 ± 0.5</td>
<td>7.4 ± 2.1</td>
<td>20.8 ± 3.9</td>
<td>>224</td>
<td>>30</td>
</tr>
<tr>
<td>2d</td>
<td>(3-Br)Ph</td>
<td>7.7 ± 0.2</td>
<td>8.3 ± 0.5</td>
<td>26 ± 5</td>
<td>>166</td>
<td>>20</td>
</tr>
<tr>
<td>2e</td>
<td>(4-Br)Ph</td>
<td>12.1 ± 0.5</td>
<td>7.4 ± 0.8</td>
<td>21 ± 5</td>
<td>>166</td>
<td>>22</td>
</tr>
<tr>
<td>2f</td>
<td>(2-Br)Ph</td>
<td>26.5 ± 3.3</td>
<td>12.0 ± 0.4</td>
<td>NDg</td>
<td>107 ± 34</td>
<td>8.9</td>
</tr>
<tr>
<td>2g</td>
<td>(3-Me)Ph</td>
<td>21.2 ± 4.5</td>
<td>5.1 ± 0.6</td>
<td>11.8 ± 1.2</td>
<td>>233</td>
<td>>46</td>
</tr>
<tr>
<td>2h</td>
<td>(4-Me)Ph</td>
<td>14.7 ± 0.2</td>
<td>4.8 ± 1.7</td>
<td>19.6 ± 11.8</td>
<td>>186</td>
<td>39</td>
</tr>
<tr>
<td>2i</td>
<td>(2-Me)Ph</td>
<td>30.8 ± 3.8</td>
<td>14.3 ± 1.1</td>
<td>NDg</td>
<td>>233</td>
<td>>16</td>
</tr>
<tr>
<td>2j</td>
<td>(3-OMe)Ph</td>
<td>NAf</td>
<td>11 ± 2</td>
<td>NDg</td>
<td>>181</td>
<td>>16</td>
</tr>
<tr>
<td>2k</td>
<td>(4-OMe)Ph</td>
<td>NAf</td>
<td>8.1 ± 1.5</td>
<td>25.0 ± 7.3</td>
<td>>226</td>
<td>>28</td>
</tr>
<tr>
<td>2l</td>
<td>(3-CF3)Ph</td>
<td>23.7 ± 0.9</td>
<td>7.7 ± 1.9</td>
<td>33.2 ± 24.9</td>
<td>>211</td>
<td>>28</td>
</tr>
<tr>
<td>2m</td>
<td>(4-CF3)Ph</td>
<td>36.3 ± 4.2</td>
<td>7.3 ± 0.8</td>
<td>31.2</td>
<td>>169</td>
<td>>23</td>
</tr>
<tr>
<td>2n</td>
<td>(2-CF3)Ph</td>
<td>NAf</td>
<td>25.0 ± 3</td>
<td>NDg</td>
<td>>169</td>
<td>>7</td>
</tr>
<tr>
<td>2o</td>
<td>(3,4-diF)Ph</td>
<td>25.4 ± 3.8</td>
<td>13.9 ± 0.4</td>
<td>NDg</td>
<td>138 ± 24</td>
<td>9.9</td>
</tr>
<tr>
<td>2p</td>
<td>(3,4-diCl)Ph</td>
<td>2.7 ± 0.3</td>
<td>9.7 ± 1.8</td>
<td>NDg</td>
<td>>168</td>
<td>>17</td>
</tr>
<tr>
<td>2q</td>
<td>(3,4-diMe)Ph</td>
<td>NAf</td>
<td>6.2 ± 0.3</td>
<td>20 ± 2</td>
<td>>181</td>
<td>>29</td>
</tr>
<tr>
<td>2r</td>
<td>(3-Cl,4-Me)Ph</td>
<td>8.0 ± 1.0</td>
<td>7.0 ± 2.0</td>
<td>37 ± 4</td>
<td>>175</td>
<td>>25</td>
</tr>
<tr>
<td>2s</td>
<td>(3-CF3,4-Cl)Ph</td>
<td>NAf</td>
<td>6.4 ± 1.7</td>
<td>NDg</td>
<td>>160</td>
<td>>25</td>
</tr>
<tr>
<td>2t</td>
<td>Cy</td>
<td>43.0 ± 0.7</td>
<td>4.5 ± 0.6</td>
<td>11 ± 2</td>
<td>44 ± 38</td>
<td>9.7</td>
</tr>
<tr>
<td>2u</td>
<td>H</td>
<td>NAf</td>
<td>88.2 ± 42.8</td>
<td>65.2</td>
<td>155 ± 50.5</td>
<td>2.5</td>
</tr>
<tr>
<td>3</td>
<td> </td>
<td>NAf</td>
<td>4.5 ± 0.6</td>
<td>NDg</td>
<td>56</td>
<td>12</td>
</tr>
<tr>
<td>4</td>
<td> </td>
<td>NAf</td>
<td>15 ± 2</td>
<td>34 ± 7</td>
<td>>192</td>
<td>>13</td>
</tr>
<tr>
<td>5</td>
<td> </td>
<td>NAf</td>
<td>80.8 ± 9.4</td>
<td>NDg</td>
<td>160 ± 18.2</td>
<td>2.3</td>
</tr>
<tr>
<td>1h</td>
<td>(3-F)Ph</td>
<td>21.0 ± 2.8</td>
<td>7.5 ± 2.5</td>
<td>42.0 ± 2.0</td>
<td>>370</td>
<td>>49</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>IC50 = concentration of compound that inhibits 50% enzyme activity in vitro. The reported values represent the mean ± SD of data derived from two independent experiments performed in duplicate.</p></fn><fn><label>b</label><p>EC50 = the effective concentration that is required to inhibit virus replication by 50% as quantified by luciferase reporter signal. The reported values represent the mean ± SD of data derived from at least three dose–response curves.</p></fn><fn><label>c</label><p>EC90 = the effective concentration that is required to inhibit virus replication by 90% as quantified by luciferase reporter signal. The reported values represent the mean ± SD of data derived from at least three independent dose–response curves.</p></fn><fn><label>d</label><p>CC50 = concentration that is required to reduce the bioreduction of MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) into formazan by 50% and is representative of the antimetabolic effect of the compound on the host cell. The reported value represents the mean ± SD of data derived from at least three dose–response curves.</p></fn><fn><label>e</label><p>SI = selectivity index (ratio of CC50 to EC50).</p></fn><fn><label>f</label><p>NA = not active. These compounds were not able to reach ≥50% inhibition of NS5B RdRp activity at 50 μM.</p></fn><fn><label>g</label><p>ND = not determined. These compounds were not able to reach 90% inhibition of HCV replication at any concentration employed.</p></fn><fn><label>h</label><p>Data from ref (17).</p></fn></table-wrap-foot></table-wrap> | {
"cell_value": [
"4.3",
"9.8",
"41",
"179",
"18",
"7.9",
"8.1",
"23.3",
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"{\"value\": \"21.0\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"1h\", \"unit\": \"μM\"}",
"{\"value\": \"7.5\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"1h\", \"unit\": \"μM\"}",
"{\"value\": \"42.0\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"1h\", \"unit\": \"μM\"}",
"{\"value\": \"370\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"1h\", \"unit\": \"μM\"}",
"{\"value\": \"49\", \"type\": \"Other\"}"
]
} |
|
PMC4203399 | tbl2 | <table-wrap><label>Table 2</label><caption><title>NS5B Mutant Inhibition Parameters for Derivative 2aa</title></caption><table><colgroup><col/><col/><col/><col/></colgroup><thead>
<tr>
<th>binding site</th>
<th>NS5B mutant</th>
<th>IC50 (μM)</th>
<th>fold change</th>
</tr></thead><tbody>
<tr>
<td>PSI</td>
<td>M414T</td>
<td>127.7 ± 5.5</td>
<td>29.7</td>
</tr>
<tr>
<td>TSI</td>
<td>P495L</td>
<td>5.1 ± 0.3</td>
<td>1.2</td>
</tr>
<tr>
<td>TSII</td>
<td>M423T</td>
<td>9.3 ± 1.5</td>
<td>2.2</td>
</tr></tbody></table><table-wrap-foot><fn><label>a</label><p>The IC50 values were evaluated against the indicated NS5B mutants as described for the wild-type NS5B and represents an average ± SD of two independent experiments in duplicate. Fold change is indicated relative to NS5B WT (IC50 = 4.3 μM).</p></fn></table-wrap-foot></table-wrap> | {
"cell_value": [
"127.7",
"29.7",
"5.1",
"1.2",
"9.3",
"2.2"
],
"cell_raw": [
"127.7 ± 5.5",
"29.7",
"5.1 ± 0.3",
"1.2",
"9.3 ± 1.5",
"2.2"
],
"cell_index": [
"CA(1,2)",
"CA(1,3)",
"CA(2,2)",
"CA(2,3)",
"CA(3,2)",
"CA(3,3)"
],
"cell_row_idx": [
1,
1,
2,
2,
3,
3
],
"cell_col_idx": [
2,
3,
2,
3,
2,
3
]
} | {
"cell_index": [
"CA(1,2)",
"CA(1,3)",
"CA(2,2)",
"CA(2,3)",
"CA(3,2)",
"CA(3,3)"
],
"cell_record": [
"{\"value\": \"127.7\", \"type\": \"Other\"}",
"{\"value\": \"29.7\", \"type\": \"Other\"}",
"{\"value\": \"5.1\", \"type\": \"Other\"}",
"{\"value\": \"1.2\", \"type\": \"Other\"}",
"{\"value\": \"9.3\", \"type\": \"Other\"}",
"{\"value\": \"2.2\", \"type\": \"Other\"}"
]
} |
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