PE/Cyanine7 anti-human CD49a Antibody
TS2/7 (See other available formats)
α1 integrin, VLA-1 α chain, Integrin α1 chain, ITGA1
Mouse IgG1, κ
HeLa cells (Human cervical cancer cell lines) were stained with CD49a (clone TS2/7) PE/Cyanine7 (filled histogram) or mouse IgG1, κ PE/Cyanine7 isotype control (open histogram).
Quantity Check Availability
328311 25 tests $105
328312 100 tests $255
CD49a is a 200 kD type I transmembrane glycoprotein also known as α1 integrin, VLA-1 α chain, or Integrin α1. It associates with CD29 (β1 integrin) to form VLA-1 complex, a collagen IV and alminin-1 receptor. It is expressed on activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells. CD49a is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.
Human, African Green, Baboon, Cynomolgus, Rhesus
Human CTL line
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Additional reported applications include: immunoprecipitation (1) and immunohistochemical staining (1) of acetone-fixed frozen tissue sections
Hemler ME, et al. 1984. J.Immunol. 132:3011
Hemler ME, et al. 1985. J. Biol. Chem. 260:15246
Fu B et al. 2017. Immunity. 47(6):1100-1113 . PubMed
Marquardt N, et al. 2019. Nat Commun. 10:3841. PubMed
Buggert M, et al. 2020. Cell. 183(7):1946-1961.e15. PubMed
Dai B, et al. 2021. Cell Reports Medicine. 2(8):100381. PubMed
Integrin alpha chain family, Type I membrane protein, alpha chain of heterodimeric integrin receptor, 200 kD. Associates with CD29 to form VLA-1 complex
Activated T cells, monocytes, NK cells, smooth muscle cells, neuronal cells, fibroblasts, and mesenchymal cells
Adhesion, leukocyte migration
With integrin β1 (CD29) forms receptor for laminin-1 and collagen IV
Fibroblasts, Mesenchymal cells, Mesenchymal Stem Cells, Monocytes, NK cells, T cells
Immunology, Stem Cells
Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiley-Liss Press. p122
Boiret N, et al. 2005. Exp. Hematol. 33:219
View information about CD49a on UniProt.org
View All CD49a Reagents Request Custom Conjugation
APC anti-human CD103 (Integrin αE)
Clone: Ber-ACT8
Brilliant Violet 421™ anti-human CD186 (CXCR6)
Clone: K041E5
Brilliant Violet 421™ anti-human CD314 (NKG2D)
Clone: 1D11
APC/Fire™ 750 anti-human CD335 (NKp46)
Clone: 9E2
8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com