Age at first birth and long-term mortality for mothers: The Ohsaki cohort study
Taichi Sakai, Yumi Sugawara, Ikue Watanabe, Takashi Watanabe, Yasutake Tomata, Naoki Nakaya, Ichiro Tsuji
MED - Public Health
Background: Although maternal age at first birth has been rising in many developed countries, its long-term effects on the health of the mothers themselves are unclear. In this study, we investigated the relationship between maternal age at first birth and long-term mortality. Methods: We conducted a cohort study of 20,624 parous Japanese women aged between 40 and 79 years in 1994 and followed up their survival for 14 years. Based on maternal age at first birth, the women were divided into four groups: ≤19 years, 20-24 years, 25-29 years, and ≥30 years. Using the 20-24 years group as a reference, hazards ratios (HRs) for all-cause and cause-specific mortality were calculated. Results: Multivariate HRs for all-cause mortality were 1.17 in the ≤19 years group, 1.09 in the 25-29 years group, and 1.33 in the ≥30 years group. A U-shaped relationship was apparent between maternal age at first birth and mortality. This relationship was also observed for mortality attributable to cancer, cardiovascular disease and other diseases. This U-shaped relationship was observed only for women born before 1935 and the birth year of the first child before 1960. Conclusion: A U-shaped relationship was apparent between maternal age at first birth and mortality. As maternal age at first birth is rising worldwide, the risk it imposes appears to have significance in the context of public health.
Environmental health and preventive medicine
Age at first birth
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Birth Order Medicine & Life Sciences 100%
Maternal Age Medicine & Life Sciences 74%
mortality Social Sciences 67%
Mothers Medicine & Life Sciences 51%
Mortality Medicine & Life Sciences 40%
cause Social Sciences 20%
Sakai, T., Sugawara, Y., Watanabe, I., Watanabe, T., Tomata, Y., Nakaya, N., & Tsuji, I. (2017). Age at first birth and long-term mortality for mothers: The Ohsaki cohort study. Environmental health and preventive medicine, 22(1), [24]. https://doi.org/10.1186/s12199-017-0631-x
Age at first birth and long-term mortality for mothers : The Ohsaki cohort study. / Sakai, Taichi; Sugawara, Yumi; Watanabe, Ikue; Watanabe, Takashi; Tomata, Yasutake; Nakaya, Naoki; Tsuji, Ichiro.
In: Environmental health and preventive medicine, Vol. 22, No. 1, 24, 2017.
Sakai, T, Sugawara, Y, Watanabe, I, Watanabe, T, Tomata, Y, Nakaya, N & Tsuji, I 2017, 'Age at first birth and long-term mortality for mothers: The Ohsaki cohort study', Environmental health and preventive medicine, vol. 22, no. 1, 24. https://doi.org/10.1186/s12199-017-0631-x
Sakai T, Sugawara Y, Watanabe I, Watanabe T, Tomata Y, Nakaya N et al. Age at first birth and long-term mortality for mothers: The Ohsaki cohort study. Environmental health and preventive medicine. 2017;22(1). 24. https://doi.org/10.1186/s12199-017-0631-x
Sakai, Taichi ; Sugawara, Yumi ; Watanabe, Ikue ; Watanabe, Takashi ; Tomata, Yasutake ; Nakaya, Naoki ; Tsuji, Ichiro. / Age at first birth and long-term mortality for mothers : The Ohsaki cohort study. In: Environmental health and preventive medicine. 2017 ; Vol. 22, No. 1.
@article{a16de481d82341c496fab92a478e5a98,
title = "Age at first birth and long-term mortality for mothers: The Ohsaki cohort study",
abstract = "Background: Although maternal age at first birth has been rising in many developed countries, its long-term effects on the health of the mothers themselves are unclear. In this study, we investigated the relationship between maternal age at first birth and long-term mortality. Methods: We conducted a cohort study of 20,624 parous Japanese women aged between 40 and 79 years in 1994 and followed up their survival for 14 years. Based on maternal age at first birth, the women were divided into four groups: ≤19 years, 20-24 years, 25-29 years, and ≥30 years. Using the 20-24 years group as a reference, hazards ratios (HRs) for all-cause and cause-specific mortality were calculated. Results: Multivariate HRs for all-cause mortality were 1.17 in the ≤19 years group, 1.09 in the 25-29 years group, and 1.33 in the ≥30 years group. A U-shaped relationship was apparent between maternal age at first birth and mortality. This relationship was also observed for mortality attributable to cancer, cardiovascular disease and other diseases. This U-shaped relationship was observed only for women born before 1935 and the birth year of the first child before 1960. Conclusion: A U-shaped relationship was apparent between maternal age at first birth and mortality. As maternal age at first birth is rising worldwide, the risk it imposes appears to have significance in the context of public health.",
keywords = "Age at first birth, Cohort study, Japan, Mortality",
author = "Taichi Sakai and Yumi Sugawara and Ikue Watanabe and Takashi Watanabe and Yasutake Tomata and Naoki Nakaya and Ichiro Tsuji",
note = "Funding Information: This work was supported by Health Sciences Research grants (H23-Junkankitou (Seisyu)-Ippan-005, H26-Junkankitou (Seisaku)-Ippan-001) from the Ministry of Health, Labour and Welfare of Japan. Publisher Copyright: {\textcopyright} The Author(s). 2017.",
journal = "Environmental Health and Preventive Medicine",
T1 - Age at first birth and long-term mortality for mothers
T2 - The Ohsaki cohort study
AU - Sakai, Taichi
AU - Sugawara, Yumi
AU - Watanabe, Ikue
AU - Watanabe, Takashi
AU - Tomata, Yasutake
AU - Nakaya, Naoki
AU - Tsuji, Ichiro
N1 - Funding Information: This work was supported by Health Sciences Research grants (H23-Junkankitou (Seisyu)-Ippan-005, H26-Junkankitou (Seisaku)-Ippan-001) from the Ministry of Health, Labour and Welfare of Japan. Publisher Copyright: © The Author(s). 2017.
N2 - Background: Although maternal age at first birth has been rising in many developed countries, its long-term effects on the health of the mothers themselves are unclear. In this study, we investigated the relationship between maternal age at first birth and long-term mortality. Methods: We conducted a cohort study of 20,624 parous Japanese women aged between 40 and 79 years in 1994 and followed up their survival for 14 years. Based on maternal age at first birth, the women were divided into four groups: ≤19 years, 20-24 years, 25-29 years, and ≥30 years. Using the 20-24 years group as a reference, hazards ratios (HRs) for all-cause and cause-specific mortality were calculated. Results: Multivariate HRs for all-cause mortality were 1.17 in the ≤19 years group, 1.09 in the 25-29 years group, and 1.33 in the ≥30 years group. A U-shaped relationship was apparent between maternal age at first birth and mortality. This relationship was also observed for mortality attributable to cancer, cardiovascular disease and other diseases. This U-shaped relationship was observed only for women born before 1935 and the birth year of the first child before 1960. Conclusion: A U-shaped relationship was apparent between maternal age at first birth and mortality. As maternal age at first birth is rising worldwide, the risk it imposes appears to have significance in the context of public health.
AB - Background: Although maternal age at first birth has been rising in many developed countries, its long-term effects on the health of the mothers themselves are unclear. In this study, we investigated the relationship between maternal age at first birth and long-term mortality. Methods: We conducted a cohort study of 20,624 parous Japanese women aged between 40 and 79 years in 1994 and followed up their survival for 14 years. Based on maternal age at first birth, the women were divided into four groups: ≤19 years, 20-24 years, 25-29 years, and ≥30 years. Using the 20-24 years group as a reference, hazards ratios (HRs) for all-cause and cause-specific mortality were calculated. Results: Multivariate HRs for all-cause mortality were 1.17 in the ≤19 years group, 1.09 in the 25-29 years group, and 1.33 in the ≥30 years group. A U-shaped relationship was apparent between maternal age at first birth and mortality. This relationship was also observed for mortality attributable to cancer, cardiovascular disease and other diseases. This U-shaped relationship was observed only for women born before 1935 and the birth year of the first child before 1960. Conclusion: A U-shaped relationship was apparent between maternal age at first birth and mortality. As maternal age at first birth is rising worldwide, the risk it imposes appears to have significance in the context of public health.
KW - Age at first birth
KW - Cohort study
KW - Japan
KW - Mortality
JO - Environmental Health and Preventive Medicine
JF - Environmental Health and Preventive Medicine