Hepatocellular tumors: Characterization with Mn-DPDP-enhanced MR imaging
Neil M. Rofsky, Jeffrey C. Weinreb, Michael E. Bernardino, Stuart W. Young, Joseph K T Lee, Marilyn E. Noz
Advanced Imaging Research Center
RAD Admin
Fifty-eight patients suspected of having focal hepatic disease were studied prior to and following the intravenous administration of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP), a hepatobiliary magnetic resonance (MR) contrast agent. Four doses (3, 5, 8, or 10 μmol/kg) of Mn-DPDP were used to test the hypothesis that Mn-DPDP-enhanced MR imaging would display enhancement in tumors of hepatocellular origin. A total of 203 lesions were evaluated. Histologic proof was available in 32 cases, and in 26 cases lesions were evaluated on the basis of characteristic imaging findings. Statistical calculations for distinction of tumors of hepatocellular origin yielded a sensitivity of 100%, a specificity of 92.0%, an accuracy of 93.6%, a positive predictive value of 75.9%, and a negative predictive value of 100%. The authors conclude that the presence and patterns of enhancement at Mn-DPDP-enhanced MR imaging permit reliable distinction between hepatocellular and nonhepatocellular tumors.
https://doi.org/10.1148/radiology.188.1.8390072
Liver neoplasms
Liver, MR
Liver, cysts
Liver, fatty
Liver, focal nodular hyperplasia
10.1148/radiology.188.1.8390072
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N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid Medicine & Life Sciences 100%
Magnetic Resonance Imaging Medicine & Life Sciences 37%
Manganese Medicine & Life Sciences 17%
Intravenous Administration Medicine & Life Sciences 13%
Contrast Media Medicine & Life Sciences 13%
Phosphates Medicine & Life Sciences 12%
Magnetic Resonance Spectroscopy Medicine & Life Sciences 11%
Rofsky, N. M., Weinreb, J. C., Bernardino, M. E., Young, S. W., Lee, J. K. T., & Noz, M. E. (1993). Hepatocellular tumors: Characterization with Mn-DPDP-enhanced MR imaging. Radiology, 188(1), 53-59. https://doi.org/10.1148/radiology.188.1.8390072
Hepatocellular tumors : Characterization with Mn-DPDP-enhanced MR imaging. / Rofsky, Neil M.; Weinreb, Jeffrey C.; Bernardino, Michael E. et al.
In: Radiology, Vol. 188, No. 1, 01.01.1993, p. 53-59.
Rofsky, NM, Weinreb, JC, Bernardino, ME, Young, SW, Lee, JKT & Noz, ME 1993, 'Hepatocellular tumors: Characterization with Mn-DPDP-enhanced MR imaging', Radiology, vol. 188, no. 1, pp. 53-59. https://doi.org/10.1148/radiology.188.1.8390072
Rofsky NM, Weinreb JC, Bernardino ME, Young SW, Lee JKT, Noz ME. Hepatocellular tumors: Characterization with Mn-DPDP-enhanced MR imaging. Radiology. 1993 Jan 1;188(1):53-59. doi: 10.1148/radiology.188.1.8390072
Rofsky, Neil M. ; Weinreb, Jeffrey C. ; Bernardino, Michael E. et al. / Hepatocellular tumors : Characterization with Mn-DPDP-enhanced MR imaging. In: Radiology. 1993 ; Vol. 188, No. 1. pp. 53-59.
@article{a7c65cd3f4b64710bfb1b209b322267d,
title = "Hepatocellular tumors: Characterization with Mn-DPDP-enhanced MR imaging",
abstract = "Fifty-eight patients suspected of having focal hepatic disease were studied prior to and following the intravenous administration of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP), a hepatobiliary magnetic resonance (MR) contrast agent. Four doses (3, 5, 8, or 10 μmol/kg) of Mn-DPDP were used to test the hypothesis that Mn-DPDP-enhanced MR imaging would display enhancement in tumors of hepatocellular origin. A total of 203 lesions were evaluated. Histologic proof was available in 32 cases, and in 26 cases lesions were evaluated on the basis of characteristic imaging findings. Statistical calculations for distinction of tumors of hepatocellular origin yielded a sensitivity of 100%, a specificity of 92.0%, an accuracy of 93.6%, a positive predictive value of 75.9%, and a negative predictive value of 100%. The authors conclude that the presence and patterns of enhancement at Mn-DPDP-enhanced MR imaging permit reliable distinction between hepatocellular and nonhepatocellular tumors.",
keywords = "Liver neoplasms, Liver, MR, Liver, cysts, Liver, fatty, Liver, focal nodular hyperplasia, Manganese",
author = "Rofsky, {Neil M.} and Weinreb, {Jeffrey C.} and Bernardino, {Michael E.} and Young, {Stuart W.} and Lee, {Joseph K T} and Noz, {Marilyn E.}",
doi = "10.1148/radiology.188.1.8390072",
T1 - Hepatocellular tumors
T2 - Characterization with Mn-DPDP-enhanced MR imaging
AU - Rofsky, Neil M.
AU - Weinreb, Jeffrey C.
AU - Bernardino, Michael E.
AU - Young, Stuart W.
AU - Lee, Joseph K T
AU - Noz, Marilyn E.
N2 - Fifty-eight patients suspected of having focal hepatic disease were studied prior to and following the intravenous administration of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP), a hepatobiliary magnetic resonance (MR) contrast agent. Four doses (3, 5, 8, or 10 μmol/kg) of Mn-DPDP were used to test the hypothesis that Mn-DPDP-enhanced MR imaging would display enhancement in tumors of hepatocellular origin. A total of 203 lesions were evaluated. Histologic proof was available in 32 cases, and in 26 cases lesions were evaluated on the basis of characteristic imaging findings. Statistical calculations for distinction of tumors of hepatocellular origin yielded a sensitivity of 100%, a specificity of 92.0%, an accuracy of 93.6%, a positive predictive value of 75.9%, and a negative predictive value of 100%. The authors conclude that the presence and patterns of enhancement at Mn-DPDP-enhanced MR imaging permit reliable distinction between hepatocellular and nonhepatocellular tumors.
AB - Fifty-eight patients suspected of having focal hepatic disease were studied prior to and following the intravenous administration of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP), a hepatobiliary magnetic resonance (MR) contrast agent. Four doses (3, 5, 8, or 10 μmol/kg) of Mn-DPDP were used to test the hypothesis that Mn-DPDP-enhanced MR imaging would display enhancement in tumors of hepatocellular origin. A total of 203 lesions were evaluated. Histologic proof was available in 32 cases, and in 26 cases lesions were evaluated on the basis of characteristic imaging findings. Statistical calculations for distinction of tumors of hepatocellular origin yielded a sensitivity of 100%, a specificity of 92.0%, an accuracy of 93.6%, a positive predictive value of 75.9%, and a negative predictive value of 100%. The authors conclude that the presence and patterns of enhancement at Mn-DPDP-enhanced MR imaging permit reliable distinction between hepatocellular and nonhepatocellular tumors.
KW - Liver neoplasms
KW - Liver, MR
KW - Liver, cysts
KW - Liver, fatty
KW - Liver, focal nodular hyperplasia
KW - Manganese
U2 - 10.1148/radiology.188.1.8390072
DO - 10.1148/radiology.188.1.8390072