Department of Radiology /
European Heart Journal /
R. Nakanishi (Rine), D.S. Berman (Daniel), M.J. Budoff (Matthew J.), H. Gransar (Heidi), S. Achenbach (Stephan), M. Al-Mallah (Mouaz), D. Andreini (Daniele), F. Cademartiri (Filippo), T.Q. Callister (Tracy), H.-J. Chang (Hyuk-Jae), et al. V.Y. Cheng (Victor Y.), K. Chinnaiyan (Kavitha), B.J.W. Chow (Benjamin), R.C. Cury (Ricardo), A. Delago (Augustin), M. Hadamitzky (Martin), J. Hausleiter (Jörg), G.M. Feuchtner (Gudrun), Y.-J. Kim (Yong-Jin), P.A. Kaufmann (Philipp A.), J. Leipsic (Jonathon), F.Y. Lin (Fay), E. Maffei (Erica), G. Pontone (Gianluca), G.L. Raff (Gilbert), L.J. Shaw (Leslee J.), T.C. Villines (Todd), A. Dunning (Allison) and J.K. Min (James)
Current but not past smoking increases the risk of cardiac events: Insights from coronary computed tomographic angiography
European Heart Journal , Volume 36 - Issue 17 p. 1031- 1040
Aims We evaluated coronary artery disease (CAD) extent, severity, and major adverse cardiac events (MACEs) in never, past, and current smokers undergoing coronary CT angiography (CCTA). Methods and results We evaluated 9456 patients (57.1 ± 12.3 years, 55.5% male) without known CAD (1588 current smokers; 2183 past smokers who quit ≥ 3 months before CCTA; and 5685 never smokers). By risk-adjusted Cox proportional-hazards models, we related smoking status to MACE (all-cause death or non-fatal myocardial infarction). We further performed 1:1:1 propensity matching for 1000 in each group evaluate event risk among individuals with similar age, gender, CAD risk factors, and symptom presentation. During a mean follow-up of 2.8 ± 1.9 years, 297 MACE occurred. Compared with never smokers, current and past smokers had greater atherosclerotic burden including extent of plaque defined as segments with any plaque (2.1 ± 2.8 vs. 2.6 ± 3.2 vs. 3.1 ± 3.3, P < 0.0001) and prevalence of obstructive CAD [1-vessel disease (VD): 10.6% vs. 14.9% vs. 15.2%, P < 0.001; 2-VD: 4.4% vs. 6.1% vs. 6.2%, P = 0.001; 3-VD: 3.1% vs. 5.2% vs. 4.3%, P < 0.001]. Compared with never smokers, current smokers experienced higher MACE risk [hazard ratio (HR) 1.9, 95% confidence interval (CI) 1.4-2.6, P < 0.001], while past smokers did not (HR 1.2, 95% CI 0.8-1.6, P = 0.35). Among matched individuals, current smokers had higher MACE risk (HR 2.6, 95% CI 1.6-4.2, P < 0.001), while past smokers did not (HR 1.3, 95% CI 0.7-2.4, P = 0.39). Similar findings were observed for risk of all-cause death. Conclusion Among patients without known CAD undergoing CCTA, current and past smokers had increased burden of atherosclerosis compared with never smokers; however, risk of MACE was heightened only in current smokers.
Keywords Coronary atherosclerosis, Coronary computed tomographic angiography, Major adverse cardiovascular risk, Smoking risk
Persistent URL doi.org/10.1093/eurheartj/ehv013, hdl.handle.net/1765/83504
Journal European Heart Journal
Organisation Department of Radiology
Nakanishi, R, Berman, D.S, Budoff, M.J, Gransar, H, Achenbach, S, Al-Mallah, M, … Min, J.K. (2015). Current but not past smoking increases the risk of cardiac events: Insights from coronary computed tomographic angiography. European Heart Journal, 36(17), 1031–1040. doi:10.1093/eurheartj/ehv013
View at Publisher
View at Scopus
Free Full Text (Manuscript at PubMed Central)
Sign in to view additional files