Clare Louise Hawkins
Clare.hawkins@sund.ku.dk
Absolute quantitative analysis of intact and oxidized amino acids by LC-MS without prior derivatization
Gamon, Luke Francis, Guo, Chaorui, He, Jianfei, Hägglund, Per Mårten, Hawkins, Clare Louise & Davies, Michael Jonathan, Sep 2020, In : Redox Biology. 36, 9 p., 101586.
Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages
Guo, Chaorui, Davies, Michael Jonathan & Hawkins, Clare Louise, Sep 2020, In : Redox Biology. 36, 14 p., 101666.
Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway
Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael Jonathan, Jan 2020, In : Redox Biology. 29, UNSP 101400.
Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis
Zhang, Y., Cartland, S. P., Henriquez, R., Patel, S., Gammelgaard, Bente, Flouda, Konstantina, Hawkins, Clare Louise & Rayner, B. S., Jan 2020, In : Redox Biology. 29, 11 p., 101409.
8-chloroadenosine alters the metabolic profile and downregulates antioxidant and DNA damage repair pathways in macrophages
Macer-Wright, J., Sileikaite, Inga, Rayner, B. & Hawkins, Clare Louise, 2020, In : Chemical Research in Toxicology. 33, 2, p. 402-413
Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification
Cai, H., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael Jonathan, 2020, In : Scientific Reports. 13 p., 666.
Dermal fibroblasts have different extracellular matrix profiles induced by TGF-beta, PDGF and IL-6 in a model for skin fibrosis
Juhl, P., Bondesen, S., Hawkins, Clare Louise, Karsdal, M. A., Bay-Jensen, A., Davies, Michael Jonathan & Siebuhr, A. S., 2020, In : Scientific Reports. 10, 1, 10 p., 17300.
Hypochlorous acid-mediated modification of proteins and its consequences
Hawkins, Clare Louise, 2020, In : Essays in Biochemistry. 64, 1, p. 75-86
Myeloperoxidase-derived damage to human plasma fibronectin: Modulation by protein binding and thiocyanate ions (SCN−)
Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael Jonathan, 2020, In : Redox Biology. 36, 13 p., 101641.
The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease
Davies, Michael Jonathan & Hawkins, Clare Louise, 2020, In : Antioxidants & Redox Signaling. 32, 13, p. 957-981
The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages
Love, D. T., Guo, Chaorui, Nikelshparg, E. I., Brazhe, N. A., Sosnovtseva, Olga & Hawkins, Clare Louise, 2020, In : Redox Biology. 36, 12 p., 101602.
8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response
Tang, V., Fu, S., Rayner, B. S. & Hawkins, Clare Louise, 2019, In : Redox Biology. 26, 11 p., UNSP 101274.
A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation
Macer-Wright, J. L., Stanley, N. R., Portman, N., Tan, J. T., Bursill, C., Rayner, B. S. & Hawkins, Clare Louise, 2019, In : Chemical Research in Toxicology. 32, 6, p. 1223-1234
Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury
Reyes, L., Bishop, D. P., Hawkins, Clare Louise & Rayner, B. S., 2019, In : Antioxidants. 8, 546 .
Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts
Reyes, L., Hawkins, Clare Louise & Rayner, B. S., 2019, In : Archives of Biochemistry and Biophysics. 665, p. 132-142
Detection, identification, and quantification of oxidative protein modifications
Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Journal of Biological Chemistry. 294, 51, p. 19683-19708
Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase
Lim, Y. J., Foo, T. C., Yeung, A. W. S., Tu, X., Ma, Y., Hawkins, Clare Louise, Witting, P. K., Jameson, G. N. L., Terentis, A. C. & Thomas, S. R., 2019, In : Biochemistry. 58, 7, p. 974-986
Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells
Cai, H., Chuang, Christine, Vanichkitrungruang, S., Hawkins, Clare Louise & Davies, Michael Jonathan, 2019, In : Free Radical Biology and Medicine. 134, p. 526-536
In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages
Zhang, Y., Rayner, B. S., Jensen, M. & Hawkins, Clare Louise, 2019, In : Journal of Visualized Experiments. 153, e60541 .
Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function
Vanichkitrungruang, S., Chuang, Christine, Hawkins, Clare Louise, Hammer, A., Hoefler, G., Malle, E. & Davies, Michael Jonathan, 2019, In : Free Radical Biology and Medicine. 136, p. 118-134
A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid
Pan, G., Rayner, B., Zhang, Y., van Reyk, D. & Hawkins, Clare Louise, 2018, In : Archives of Biochemistry and Biophysics. 642, p. 23-30 8 p.
A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?
Hawkins, Clare Louise, 2018, In : Acta Physiologica. 223, 4, 3 p., e13106 .
Research output: Contribution to journal › Editorial › Research › peer-review
Cellular responses to radical propagation from ion-implanted plasma polymer surfaces
Stewart, C. A. C., Akhavan, B., Santos, M., Hung, J., Hawkins, Clare Louise, Bao, S., Wise, S. G. & Bilek, M. M. M., 2018, In : Applied Surface Science. 456, p. 701-710
Protein carbamylation: a key driver of vascular calcification during chronic kidney disease
Hawkins, Clare Louise, 2018, In : Kidney International. 94, 1, p. 12-14
Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation
Rayner, B. S., Zhang, Y., Brown, B. E., Reyes, L., Cogger, V. C. & Hawkins, Clare Louise, 2018, In : Free Radical Biology and Medicine. 129, p. 25-34
The dys-regulation of anti-oxidant defense via an impairment of Nrf2 response in the pathology of Friedreich's ataxia: [Meeting Abstract]
Chiang, S., Anzovino, A., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L. -., 2018, In : Free Radical Biology and Medicine. 120, p. S35-S35 OP-19 .
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis
Anzovino, A., Chiang, S., Brown, B. E., Hawkins, Clare Louise, Richardson, D. R. & Huang, M. L., Dec 2017, In : American Journal of Pathology. 187, 12, p. 2858-2875 18 p.
CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis
Ridiandries, A., Tan, J. T. M., Ravindran, D., Williams, H., Medbury, H. J., Lindsay, L., Hawkins, Clare Louise, Prosser, H. C. G. & Bursill, C. A., Mar 2017, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31, 3, p. 1179-1192 14 p.
Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael Jonathan & Hawkins, Clare Louise, 2017, In : Redox Biology. 12, p. 872-882 12 p.
Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction
Abdo, A., Rayner, B. S., van Reyk, D. M. & Hawkins, Clare Louise, 2017, In : Redox Biology. 13, p. 623-632 10 p.
Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
Indo, H. P., Hawkins, Clare Louise, Nakanishi, I., Matsumoto, K., Matsui, H., Suenaga, S., Davies, Michael Jonathan, St Clair, D. K., Ozawa, T. & Majima, H. J., 2017, Pharmacology of Mitochondria. Springer, Vol. 240. p. 439-456 18 p. (Handbook of Experimental Pharmacology, Vol. 240).
A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity
Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, Clare Louise & Richardson, D. R., 30 Dec 2016, In : The Journal of Biological Chemistry. 291, 53, p. 27042-27061 20 p.
Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space
Indo, H. P., Majima, H. J., Terada, M., Suenaga, S., Tomita, K., Yamada, S., Higashibata, A., Ishioka, N., Kanekura, T., Nonaka, I., Hawkins, Clare Louise, Davies, Michael Jonathan, Clair, D. K. S. & Mukai, C., 16 Dec 2016, In : Scientific Reports. 6, 10 p., 39015.
Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development
Tweeddale, H. J., Hawkins, Clare Louise, Janmie, J. F., Truscott, R. J. W. & Davies, Michael Jonathan, Oct 2016, In : Free Radical Research. 50, 10, p. 1116-1130 15 p.
β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia
Karimi Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N. A., Hamilton, E. J., Hawkins, Clare Louise & Figtree, G. A., 19 Feb 2016, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 5, 2, e002824.
Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages
Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, Michael Jonathan & Hawkins, Clare Louise, 2016, In : Free Radical Biology & Medicine. 94, p. 88-98 11 p.
Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
Ismael, F. O., Barrett, T. J., Sheipouri, D., Brown, B. E., Davies, Michael Jonathan & Hawkins, Clare Louise, 2016, In : P L o S One. 11, 12, 16 p., e0168844.
Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin and enhances rat gastric tumor cell invasion
Indo, H. P., Matsui, H., Chen, J., Zhu, H., Hawkins, Clare Louise, Davies, Michael Jonathan, Yarana, C., Clair, D. K. S. & Majima, H. J., 1 Jul 2015, In : Journal of Clinical Biochemistry and Nutrition. 57, 1, p. 13-20 8 p.
Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage
Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, Michael Jonathan & Hawkins, Clare Louise, Jul 2015, In : Free Radical Biology & Medicine. 84, p. 279-288 10 p.
Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants
Bonifay, V., Barrett, T. J., Pattison, D. I., Davies, Michael Jonathan, Hawkins, Clare Louise & Ashby, M. T., 15 Dec 2014, In : Archives of Biochemistry and Biophysics. 564, p. 1-11 11 p.
Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?
Hawkins, Clare Louise, Nov 2014, In : Kidney International. 86, 5, p. 875-7 3 p.
Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells
Rayner, B. S., Love, D. T. & Hawkins, Clare Louise, Jun 2014, In : Free Radical Biology & Medicine. 71, p. 240-55 16 p.
Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides
Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael Jonathan, May 2014, In : Free Radical Biology & Medicine. 70, p. 96-105 10 p.
Detection and characterisation of radicals in biological materials using EPR methodology
Hawkins, Clare Louise & Davies, Michael Jonathan, Feb 2014, In : B B A - Reviews on Cancer. 1840, 2, p. 708-21 14 p.
Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction
Galougahi, K. K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, Michael Jonathan, Hawkins, Clare Louise, Rasmussen, H. H. & Figtree, G. A., 2014, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731
Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells
Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, Michael Jonathan & Hawkins, Clare Louise, Dec 2013, In : Free Radical Biology & Medicine. 65, p. 1352-62 11 p.
Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)
Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael Jonathan & Hawkins, Clare Louise, 15 Jan 2013, In : Biochemical Journal. 449, 2, p. 531-42 12 p.
Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines
Summers, F. A., Forsman Quigley, A. & Hawkins, Clare Louise, 24 Aug 2012, In : Biochemical and Biophysical Research Communications. 425, 2, p. 157-61 5 p.
Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids
Pattison, D. I., Davies, Michael Jonathan & Hawkins, Clare Louise, Aug 2012, In : Free Radical Research. 46, 8, p. 975-95 21 p.
Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome
Boon, A., Hawkins, Clare Louise, Bisht, K., Coombes, J. S., Bakrania, B., Wagner, K. & Bulmer, A. C., 15 May 2012, In : Free Radical Biology & Medicine. 52, 10, p. 2120-7 8 p.