Epidemiology & Infection
Volume 145 Issue 2
Goats with aspartic acid or ser...
Ricci, Antonia Allende, Ana Bolton, Declan Chemaly, Marianne Davies, Robert Fernández Escámez, Pablo Salvador Gironés, Rosina Herman, Lieve Koutsoumanis, Kostas Lindqvist, Roland Nørrung, Birgit Robertson, Lucy Ru, Giuseppe Sanaa, Moez Skandamis, Panagiotis Speybroeck, Niko Simmons, Marion Kuile, Benno Ter Threlfall, John Wahlström, Helene Acutis, Pier‐Luigi Andreoletti, Olivier Goldmann, Wilfred Langeveld, Jan Windig, Jack J Ortiz Pelaez, Angel and Snary, Emma 2017. Genetic resistance to transmissible spongiform encephalopathies (TSE) in goats. EFSA Journal, Vol. 15, Issue. 8,
Papasavva-Stylianou, Penelope Simmons, Marion Mathieson Ortiz-Pelaez, Angel Windl, Otto Spiropoulos, John Georgiadou, Soteria and Caughey, Byron 2017. Effect of Polymorphisms at Codon 146 of the Goat PRNP Gene on Susceptibility to Challenge with Classical Scrapie by Different Routes. Journal of Virology, Vol. 91, Issue. 22,
Cinar, M.U. Schneider, D.A. Waldron, D.F. O'Rourke, K.I. and White, S.N. 2018. Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years. The Veterinary Journal, Vol. 233, Issue. , p. 19.
Jeong, Min-Ju Kim, Yong-Chan Jeong, Byung-Hoon and Rezaei, Human 2018. Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats. PLOS ONE, Vol. 13, Issue. 10, p. e0206209.
Simmons, Marion M. Thorne, Leigh Ortiz-Pelaez, Angel Spiropoulos, John Georgiadou, Soteria Papasavva-Stylianou, Penelope Andreoletti, Olivier Hawkins, Stephen A.C. Meloni, Daniela and Cassar, Claire 2020. Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype?. Journal of Veterinary Diagnostic Investigation, p. 104063871989632.
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus
S. GEORGIADOU (a1), A. ORTIZ-PELAEZ (a2), M. M. SIMMONS (a2), O. WINDL (a2), M. DAWSON (a2), P. NEOCLEOUS (a1) and P. PAPASAVVA-STYLIANOU (a1)...
1 Veterinary Services, Nicosia, Cyprus
2 Animal and Plant Health Agency, New Haw, Addlestone, Surrey, UK
Published online by Cambridge University Press: 18 October 2016
The results of the study reported here are part of an ongoing integrated research programme aimed at producing additional, robust, evidence on the genetic resistance to classical scrapie in goats, with particular reference to codon 146. The study targeted animals aged ⩾6 years, which were born and raised in infected herds and were being culled for management reasons. A total of 556 animals were tested, and all positive animals (n = 117) were of the susceptible NN genotype. A total of 246 goats heterozygous or homozygous for putatively resistant alleles (S146 and D146) were screened with no positive results. The outcome of this study supports the hypothesis that the D146 and S146 alleles could be used as the basis for a nationwide strategy for breeding for resistance in the Cypriot goat population.
S. GEORGIADOU (a1), A. ORTIZ-PELAEZ (a2), M. M. SIMMONS (a2), O. WINDL (a2), M. DAWSON (a2), P. NEOCLEOUS (a1) and P. PAPASAVVA-STYLIANOU (a1)
COPYRIGHT: © Cambridge University Press 2016
*Author for correspondence: Dr A. Ortiz-Pelaez. (Email: angortpel@yahoo.com)
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