George Staples Leight Jr.
The SEON Laboratory (George Leight, M.D., Sanford Garner, Ph.D., and Kenneth McCarty, Ph.D.) is pursuing several lines of research that have evolved from our primary interest in regulation of parathyroid hormone (PTH) secretion and calcium homeostasis.
1) We have developed a reverse transcription-polymerase chain reaction (RT-PCR)-based assay for the expression of mRNA for the calcium-sensing receptor (CaR) of the parathyroid gland and other tissues. This recently described protein has already been shown to be involved in some inherited abnormalities of calcium homeostasis. We have measured the level of expression of this gene in parathyroid tissue from patients undergoing surgery for primary hyperparathyroidism, and an abstract on the results is being submitted to the American Association of Endocrine Surgeons. Additional analyses of both normal parathyroid tissue and parathyroids removed from patients with secondary hyperparathyroidism will be performed in the coming year. This project is also proposed to eventually include assay of expression levels of mRNAs for the vitamin D receptor and PTH. Coupled with characterization of in vitro secretion of PTH over a range of calcium concentrations, information on expression of these genes will allow a more complete exploration of the etiology of hyperparathyroidism and possible treatment of these disorders.
2) Another clinically-related project in our laboratory is the rapid, intraoperative assay of PTH that can be completed within 15 minutes after blood sampling during surgery for either primary or secondary hyperparathyroidism. The half-life of circulating PTH is <3 minutes; therefore a sample taken 5 minutes after tissue excision has already proven to be informative of completeness of removal of adenomatous or hyperplastic parathyroid tissue. We have accumulated data during 1996 on a total of 49 cases of parathyroid surgery, 38 for primary hyperparathyroidism and 11 for secondary hyperparathyroidism. The utility of this assay in the surgical treatment of hyperparathyroidism has been clearly demonstrated. We are currently applying to the Diagnostic Technology Committee for recognition of this test procedure at Duke University Medical Center as a billable test. Significant reductions in the cost of parathyroid surgery are anticipated as a result of implementing this test for all cases. The time required for surgical exploration in primary hyperparathyroidism can be reduced by approximately one hour per case. In addition, the assay provides additional information beyond that currently obtained from frozen section pathology, and the need for this expensive test will be greatly reduced. Finally, the shorter time for surgery and the less extensive exploration made possible by the information obtained with the intraoperative PTH procedure will allow many (approximately 50% by published report) to be completed on an outpatient basis. The cumulative effect of these various savings and the higher reimbursement percentage for outpatient vs. inpatient surgery will result in a net savings of approximately $100,000 to DUMC even after the cost of the procedure is factored in.
3) An additional basic research project that is ongoing in our laboratory is an exploration of the mechanism of hyperparathyroidism in animal models using neonatal and lactating rats that exhibit relatively nonsuppressible PTH secretion in the presence of elevated serum calcium concentrations. The role of vitamin D as a physiologic inhibitor of PTH secretion is also being explored in these models, in addition to the modulation of the parathyroid calcium receptor. A grant proposal was submitted to NIH in June of 1996 on this project. The proposal was not submitted to complete review, but the comments of the initial reviewers should be helpful in revising and resubmitting this proposal with additional data.
Professor of Surgery, Surgical Oncology, Surgery 1993
101 Bell Bldg, Durham, NC 27710
Box 3513 Med Ctr, Durham, NC 27710
leigh001@mc.duke.edu (919) 684-6849
Chief Resident, Surgery, Duke University 1978 - 1979
Senior Resident in Surgery, Surgery, Duke University 1976 - 1978
Resident, Surgery, Duke University 1973 - 1974
Intern, Surgery, Duke University 1972 - 1973
M.D., Duke University 1972
Associate Professor of Surgery in the Department of Surgery, Surgery, Clinical Science Departments 1984 - 1993
Parathyroid and Thymus Transplants in DiGeorge Syndrome awarded by National Institutes of Health 2004 - 2006
Untch, Brian R., Mohamed Abdelgadir Adam, Randall P. Scheri, Kyla M. Bennett, Darshana Dixit, Cynthia Webb, George S. Leight, and John A. Olson. "Surgeon-performed ultrasound is superior to 99Tc-sestamibi scanning to localize parathyroid adenomas in patients with primary hyperparathyroidism: results in 516 patients over 10 years.." J Am Coll Surg 212, no. 4 (April 2011): 522–29. https://doi.org/10.1016/j.jamcollsurg.2010.12.038.
Olson, John A., G Thomas Budd, Lisa A. Carey, Lyndsay A. Harris, Laura J. Esserman, Gini F. Fleming, Paul K. Marcom, et al. "Improved surgical outcomes for breast cancer patients receiving neoadjuvant aromatase inhibitor therapy: results from a multicenter phase II trial.." J Am Coll Surg 208, no. 5 (May 2009): 906–14. https://doi.org/10.1016/j.jamcollsurg.2009.01.035.
Untch, Brian R., Michael E. Barfield, Moahad Dar, Darshana Dixit, George S. Leight, and John A. Olson. "Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism.." Surgery 142, no. 6 (December 2007): 1022–26. https://doi.org/10.1016/j.surg.2007.09.026.
Irvin, George L., Denise M. Carneiro, and Carmen C. Solorzano. "Progress in the operative management of sporadic primary hyperparathyroidism over 34 years.." Ann Surg 239, no. 5 (May 2004): 704–8. https://doi.org/10.1097/01.sla.0000124448.49794.74.
Leight, G. S. "Progress in the operative management of sporadic primary hyperparathyroidism over 34 years - Discussion." Annals of Surgery 239, no. 5 (May 1, 2004): 708–11.
Miller, Keith L., Lawrence B. Marks, Robert C. Barrier, George S. Leight, Robert W. Clough, Robert G. Prosnitz, and Rex C. Bentley. "Increased sectioning of pathologic specimens with ductal carcinoma in situ of the breast: are there clinical consequences?." Clin Breast Cancer 4, no. 3 (August 2003): 198–202. https://doi.org/10.3816/cbc.2003.n.025.
Olson, John A., and George S. Leight. "Surgical management of secondary hyperparathyroidism.." Adv Ren Replace Ther 9, no. 3 (July 2002): 209–18. https://doi.org/10.1053/jarr.2002.34840.
Shivers, Steve, Charles Cox, George Leight, Daniel Beauchamp, Peter Blumencranz, Merrick Ross, and Douglas Reintgen. "Final results of the Department of Defense multicenter breast lymphatic mapping trial.." Ann Surg Oncol 9, no. 3 (April 2002): 248–55. https://doi.org/10.1007/bf02573062.
Dupont, E. L., V. J. Kamath, E. M. Ramnath, S. C. Shivers, C. Cox, C. Berman, G. S. Leight, et al. "The role of lymphoscintigraphy in the management of the patient with breast cancer.." Ann Surg Oncol 8, no. 4 (May 2001): 354–60. https://doi.org/10.1007/s10434-001-0354-4.
Wilkinson, R. H., G. S. Leight, S. C. Garner, and S. Borges-Neto. "Complementary nature of radiotracer parathyroid imaging and intraoperative parathyroid hormone assays in the surgical management of primary hyperparathyroid disease: case report and review.." Clin Nucl Med 25, no. 3 (March 2000): 173–78. https://doi.org/10.1097/00003072-200003000-00002.
Garner, S. C., and G. S. Leight. "Initial experience with intraoperative PTH determinations in the surgical management of 130 consecutive cases of primary hyperparathyroidism.." Surgery 126, no. 6 (December 1999): 1132–37. https://doi.org/10.1067/msy.2099.101429.
Louis, J. D. S. T., G. S. Leicht, and D. S. Tyler. "Follicular neoplasms: The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery." Seminars in Surgical Oncology 16, no. 1 (December 1, 1999): 5–11.
St Louis, J. D., G. S. Leight, and D. S. Tyler. "Follicular neoplasms: the role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery.." Semin Surg Oncol 16, no. 1 (January 1999): 5–11. https://doi.org/10.1002/(sici)1098-2388(199901/02)16:1<5::aid-ssu2>3.0.co;2-u.
Warmuth, M. A., G. Bowen, L. R. Prosnitz, L. Chu, G. Broadwater, B. Peterson, G. Leight, and E. P. Winer. "Complications of axillary lymph node dissection for carcinoma of the breast: a report based on a patient survey.." Cancer 83, no. 7 (October 1, 1998): 1362–68. https://doi.org/10.1002/(sici)1097-0142(19981001)83:7<1362::aid-cncr13>3.0.co;2-2.
Coveney, E., C. R. Weltz, R. Greengrass, J. D. Iglehart, G. S. Leight, S. M. Steele, and H. K. Lyerly. "Use of paravertebral block anesthesia in the surgical management of breast cancer: experience in 156 cases.." Ann Surg 227, no. 4 (April 1998): 496–501. https://doi.org/10.1097/00000658-199804000-00008.
Clary, B. M., S. C. Garner, and G. S. Leight. "Intraoperative parathyroid hormone monitoring during parathyroidectomy for secondary hyperparathyroidism.." Surgery 122, no. 6 (December 1997): 1034–38. https://doi.org/10.1016/s0039-6060(97)90206-3.
Danto, L. A., L. A. Carty, N. W. Thompson, G. L. Irvin, J. G. Norman, P. LoGerfo, J. A. Macfie, G. S. Leight, and R. Udelsman. "Concise parathyroidectomy: The impact of preoperative SPECT Tc-99m sestamibi scanning and intraoperative quick parathormone assay - Discussion." Surgery 122, no. 6 (December 1, 1997): 1114–16.
Garner, S. C., T. K. Hinson, K. S. McCarty, M. Leight, G. S. Leight, and L. D. Quarles. "Quantitative analysis of the calcium-sensing receptor messenger RNA in parathyroid adenomas.." Surgery 122, no. 6 (December 1997): 1166–75. https://doi.org/10.1016/s0039-6060(97)90223-3.
Klein, S. M., R. A. Greengrass, N. Knudsen, G. Leight, and D. S. Warner. "Regional anesthesia for thyroidectomy in two patients with amiodarone-induced hyperthyroidism.." Anesth Analg 85, no. 1 (July 1997): 222–24. https://doi.org/10.1097/00000539-199707000-00041.
Lee, V. S., C. E. Spritzer, R. E. Coleman, R. H. Wilkinson, A. C. Coogan, and G. S. Leight. "The complementary roles of fast spin-echo MR imaging and double-phase 99m Tc-sestamibi scintigraphy for localization of hyperfunctioning parathyroid glands.." Ajr Am J Roentgenol 167, no. 6 (December 1996): 1555–62. https://doi.org/10.2214/ajr.167.6.8956597.
Molinari, A. S., G. L. Irvin, G. T. Deriso, and L. Bott. "Incidence of multiglandular disease in primary hyperparathyroidism determined by parathyroid hormone secretion.." Surgery 120, no. 6 (December 1996): 934–36. https://doi.org/10.1016/s0039-6060(96)80036-5.
Monchik, J. M., C. Proye, C. Irvin, I. B. Rosen, G. S. Leight, B. Duarte, and J. P. Wei. "Incidence of multiglandular disease in primary hyperparathyroidism determined by parathyroid hormone secretion - Discussion." Surgery 120, no. 6 (December 1, 1996): 936–37.
Lee, V. S., M. S. Webb, S. Martinez, C. P. McKay, and G. S. Leight. "Uremic leontiasis ossea: "bighead" disease in humans? Radiologic, clinical, and pathologic features.." Radiology 199, no. 1 (April 1996): 233–40. https://doi.org/10.1148/radiology.199.1.8633151.
Lee, V. S., R. H. Wilkinson, G. S. Leight, A. C. Coogan, and R. E. Coleman. "Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging.." Radiology 197, no. 3 (December 1995): 627–33. https://doi.org/10.1148/radiology.197.3.7480730.
Carling, T., J. Rastad, P. Ridefelt, A. Gobl, P. Hellman, K. Oberg, L. Rask, C. Larsson, C. Juhlin, and E. al. "Hyperparathyroidism of multiple endocrine neoplasia type 1: Candidate gene and parathyroid calcium sensing protein expression." Surgery 118, no. 6 (1995): 924–31. https://doi.org/10.1016/S0039-6060(05)80095-9.
Weigel, R. J., S. A. Wells, J. C. Gunnells, and G. S. Leight. "Surgical treatment of primary hyperaldosteronism.." Ann Surg 219, no. 4 (April 1994): 347–52. https://doi.org/10.1097/00000658-199404000-00004.
Anscher, M. S., P. Jones, L. R. Prosnitz, W. Blackstock, M. Hebert, R. Reddick, A. Tucker, R. Dodge, G. Leight, and J. D. Iglehart. "Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy.." Ann Surg 218, no. 1 (July 1993): 22–28. https://doi.org/10.1097/00000658-199307000-00005.
Dunnick, N. R., G. S. Leight, M. A. Roubidoux, R. A. Leder, E. Paulson, and L. Kurylo. "CT in the diagnosis of primary aldosteronism: sensitivity in 29 patients.." Ajr Am J Roentgenol 160, no. 2 (February 1993): 321–24. https://doi.org/10.2214/ajr.160.2.8424342.
Lairmore, T. C., D. W. Ball, S. B. Baylin, S. A. W. Jr, J. B. Hanks, J. V. Heerden, and G. S. L. Jr. "Management of pheochromocytomas in patients with multiple endocrine neoplasia type 2 syndromes." Annals of Surgery 217, no. 6 (1993): 595–603.
Leight, G. S., and J. E. Varhaug. "Preoperative endocrine tumor localization utilizing a cost-effective approach.." Curr Opin Gen Surg, 1993, 108–14.
Schachter, P. P., M. D. Christy, I. S. Avigad, M. Shabtay, and G. S. Leight. "Non-autonomy of parathyroid hormone secretion in acute primary hyperparathyroidism.." Clin Endocrinol (Oxf) 37, no. 6 (December 1992): 565–69. https://doi.org/10.1111/j.1365-2265.1992.tb01489.x.
Leight, G. S. "Angiographic ablation of mediastinal parathyroid adenoma.." Ann Surg 215, no. 2 (February 1992): 99–100. https://doi.org/10.1097/00000658-199202000-00001.
Schachter, P. P., M. D. Christy, M. Shabtay, A. Ayalon, and G. S. Leight. "The role of circulating N-terminal parathyroid hormone fragments in the early postparathyroid adenomectomy period.." Surgery 110, no. 6 (December 1991): 1048–52.
Hanson, M. W., J. M. Feldman, C. A. Beam, G. S. Leight, and R. E. Coleman. "Iodine 131-labeled metaiodobenzylguanidine scintigraphy and biochemical analyses in suspected pheochromocytoma.." Arch Intern Med 151, no. 7 (July 1991): 1397–1402.
Branum, G. D., R. E. Epstein, G. S. Leight, and H. F. Seigler. "The role of resection in the management of melanoma metastatic to the adrenal gland.." Surgery 109, no. 2 (February 1991): 127–31.
Schachter, P. P., M. D. Christy, B. Lobaugh, and G. S. Leight. "Parathyroid hormone secretion and target organ response in experimental acute pancreatitis.." Arch Surg 126, no. 2 (February 1991): 139–42. https://doi.org/10.1001/archsurg.1991.01410260023003.
Schachter, P., M. D. Christy, G. S. Leight, and B. Lobaugh. "Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism.." Surgery 108, no. 6 (December 1990): 1040–46.
McCarty, K. S., L. B. Kinsel, G. Georgiade, and G. Leight. "Long-term prognostic implications of sex-steroid receptors in human cancer.." Prog Clin Biol Res 322 (1990): 279–93.
Lobaugh, B., F. A. Neelon, H. Oyama, N. Buckley, S. Smith, M. Christy, and G. S. Leight. "Circadian rhythms for calcium, inorganic phosphorus, and parathyroid hormone in primary hyperparathyroidism: functional and practical considerations.." Surgery 106, no. 6 (December 1989): 1009–16.
Schachter, P., N. Buckley, H. Oyama, M. Christy, G. Leight, and B. Lobaugh. "Primary hyperparathyroidism: a new experimental animal model.." Surgery 106, no. 6 (December 1989): 997–1001.
Baker, M. E., R. Blinder, C. Spritzer, G. S. Leight, R. J. Herfkens, and N. R. Dunnick. "MR evaluation of adrenal masses at 1.5 T.." Ajr Am J Roentgenol 153, no. 2 (August 1989): 307–12. https://doi.org/10.2214/ajr.153.2.307.
Burton, G. V., L. L. Hart, G. S. Leight, J. D. Iglehart, K. S. McCarty, and E. B. Cox. "Cystosarcoma phyllodes. Effective therapy with cisplatin and etoposide chemotherapy.." Cancer 63, no. 11 (June 1, 1989): 2088–92. https://doi.org/10.1002/1097-0142(19890601)63:11<2088::aid-cncr2820631103>3.0.co;2-c.
Ljung, B. M., B. Mayall, C. Lottich, C. Boyer, S. S. Sylvester, G. S. Leight, H. F. Siegler, and H. S. Smith. "Cell dissociation techniques in human breast cancer--variations in tumor cell viability and DNA ploidy.." Breast Cancer Res Treat 13, no. 2 (March 1989): 153–59. https://doi.org/10.1007/bf01806527.
Kinsel, L. B., E. Szabo, G. L. Greene, J. Konrath, G. S. Leight, and K. S. McCarty. "Immunocytochemical analysis of estrogen receptors as a predictor of prognosis in breast cancer patients: comparison with quantitative biochemical methods.." Cancer Res 49, no. 4 (February 15, 1989): 1052–56.
Donnal, J. F., M. E. Baker, B. S. Mahony, and G. S. Leight. "Benign retroperitoneal schwannoma.." Urology 31, no. 4 (April 1988): 332–34. https://doi.org/10.1016/0090-4295(88)90093-3.
Burton, G. V., J. L. Flowers, E. B. Cox, G. S. Leight, G. A. Dent, K. R. Geisinger, and K. S. McCarty. "Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response.." Breast Cancer Res Treat 10, no. 3 (December 1987): 287–91. https://doi.org/10.1007/bf01805766.
Burton, G. V., E. B. Cox, G. S. Leight, L. R. Prosnitz, J. D. Iglehart, G. A. Olsen, H. F. Seigler, and L. L. Hart. "Inflammatory breast carcinoma. Effective multimodal approach.." Arch Surg 122, no. 11 (November 1987): 1329–32. https://doi.org/10.1001/archsurg.1987.01400230117020.
Kochersberger, G., N. J. Buckley, G. S. Leight, S. Martinez, S. Studenski, J. Vogler, and K. W. Lyles. "What is the clinical significance of bone loss in primary hyperparathyroidism?." Arch Intern Med 147, no. 11 (November 1987): 1951–53.
Kier, R., R. A. Blinder, R. J. Herfkens, G. S. Leight, C. E. Spritzer, and B. A. Carroll. "MR imaging with surface coils in primary hyperparathyroidism.." J Comput Assist Tomogr 11, no. 5 (September 1987): 863–68. https://doi.org/10.1097/00004728-198709000-00023.
Baker, M. E., C. Spritzer, R. Blinder, R. J. Herfkens, G. S. Leight, and N. R. Dunnick. "Benign adrenal lesions mimicking malignancy on MR imaging: report of two cases.." Radiology 163, no. 3 (June 1987): 669–71. https://doi.org/10.1148/radiology.163.3.3575711.
BUCKLEY, N., G. S. LEIGHT, F. A. NEELON, H. OYAMA, M. CHRISTY, and B. LOBAUGH. "DISTURBANCE OF THE CIRCADIAN-RHYTHM FOR PARATHYROID-HORMONE IN PRIMARY HYPERPARATHYROIDISM - A DEFECT RESOLVED BY SURGERY." Clinical Research 35, no. 3 (April 1, 1987): A499–A499.
Farndon, J. R., J. M. Geraghty, W. G. Dilley, S. Handwerger, and G. S. Leight. "Serum gastrin, calcitonin, and prolactin as markers of multiple endocrine neoplasia syndromes in patients with primary hyperparathyroidism.." World J Surg 11, no. 2 (April 1987): 252–57. https://doi.org/10.1007/bf01656411.
BUCKLEY, N., G. S. LEIGHT, F. A. NEELON, H. OYAMA, M. CHRISTY, and B. LOBAUGH. "DISTURBANCE OF THE CIRCADIAN-RHYTHM FOR PARATHYROID-HORMONE IN PRIMARY HYPERPARATHYROIDISM - A DEFECT RESOLVED BY SURGERY." Clinical Research 35, no. 1 (January 1, 1987): A22–A22.
Buckley, N. J., B. Lobaugh, M. D. Christy, and G. S. Leight. "Does parathormone stimulate gastrin secretion? A study of hormonal interrelationships." Surgical Forum 38 (January 1, 1987): 79–81.
Buckley, N. J., W. M. Burch, and G. S. Leight. "Malignant teratoma in the thyroid gland of an adult: a case report and a review of the literature.." Surgery 100, no. 5 (November 1986): 932–37.
McCarty, K. S., E. Szabo, J. L. Flowers, E. B. Cox, G. S. Leight, L. Miller, J. Konrath, J. T. Soper, D. A. Budwit, and W. T. Creasman. "Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors." Cancer Research 46, no. 8 SUPPL. (October 15, 1986).
Kier, R., R. J. Herfkens, R. A. Blinder, G. S. Leight, J. A. Utz, and P. M. Silverman. "MRI with surface coils for parathyroid tumors: preliminary investigation.." Ajr Am J Roentgenol 147, no. 3 (September 1986): 497–500. https://doi.org/10.2214/ajr.147.3.497.
MCCARTY, K. S., E. SZABO, J. L. FLOWERS, E. B. COX, G. S. LEIGHT, L. MILLER, J. KONRATH, et al. "USE OF A MONOCLONAL ANTIESTROGEN RECEPTOR ANTIBODY IN THE IMMUNOHISTOCHEMICAL EVALUATION OF HUMAN-TUMORS." Cancer Research 46, no. 8 (August 1, 1986): 4244–48.
McCarty, K. S., E. Szabo, J. L. Flowers, E. B. Cox, G. S. Leight, L. Miller, J. Konrath, J. T. Soper, D. A. Budwit, and W. T. Creasman. "Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors.." Cancer Res 46, no. 8 Suppl (August 1986): 4244s-4248s.
Neuss, M. N., J. T. Garbutt, G. S. Leight, and J. O. Moore. "Intraluminal thrombus and bowel obstruction in acute leukemia due to bleeding Meckel's diverticulum.." Am J Med 80, no. 6 (June 1986): 1194–96. https://doi.org/10.1016/0002-9343(86)90685-6.
Farndon, J. R., G. S. Leight, W. G. Dilley, S. B. Baylin, R. C. Smallridge, T. S. Harrison, and S. A. Wells. "Familial medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity.." Br J Surg 73, no. 4 (April 1986): 278–81. https://doi.org/10.1002/bjs.1800730411.
Brunt, L. M., J. D. Veldhuis, W. G. Dilley, J. R. Farndon, R. J. Santen, G. S. Leight, and S. A. Wells. "Stimulation of insulin secretion by a rapid intravenous calcium infusion in patients with beta-cell neoplasms of the pancreas.." J Clin Endocrinol Metab 62, no. 1 (January 1986): 210–16. https://doi.org/10.1210/jcem-62-1-210.
Dilley, W. G., D. E. Haagensen, G. S. Leight, S. Ammirata, S. R. Davis, J. S. Silva, N. Zamcheck, J. J. Lokich, and S. A. Wells. "Fluoxymesterone stimulation of tumor marker secretion in patients with breast carcinoma.." Breast Cancer Res Treat 8, no. 3 (1986): 205–15. https://doi.org/10.1007/bf01807333.
Wells, S. A., G. S. Leight, M. Hensley, and W. G. Dilley. "Hyperparathyroidism associated with the enlargement of two or three parathyroid glands.." Ann Surg 202, no. 5 (November 1985): 533–38. https://doi.org/10.1097/00000658-198511000-00001.
Wells, S. A., W. G. Dilley, J. A. Farndon, G. S. Leight, and S. B. Baylin. "Early diagnosis and treatment of medullary thyroid carcinoma.." Arch Intern Med 145, no. 7 (July 1985): 1248–52.
Cantley, L. K., D. A. Ontjes, C. W. Cooper, C. G. Thomas, G. S. Leight, and S. A. Wells. "Parathyroid hormone secretion from dispersed human hyperparathyroid cells: increased secretion in cells from hyperplastic glands versus adenomas.." J Clin Endocrinol Metab 60, no. 5 (May 1985): 1032–37. https://doi.org/10.1210/jcem-60-5-1032.
Kier, R., P. M. Silverman, M. Korobkin, S. Wain, G. Leight, and W. Burch. "Malignant teratoma of the thyroid in an adult: CT appearance.." J Comput Assist Tomogr 9, no. 1 (January 1985): 174–76. https://doi.org/10.1097/00004728-198501000-00030.
Ingram, D. L., J. A. Mossler, J. Snowhite, G. S. Leight, and K. S. McCarty. "Granular cell tumors of the breast. Steroid receptor analysis and localization of carcinoembryonic antigen, myoglobin, and S100 protein.." Arch Pathol Lab Med 108, no. 11 (November 1984): 897–901.
Leight, G. S., S. A. Wells, and K. S. McCarty. "Sex steroid receptor concentration in breast carcinoma tissue: effect of devascularization during mastectomy.." Surgery 95, no. 3 (March 1984): 256–60.
BRUNT, L. M., W. G. DILLEY, J. R. FARNDON, G. S. LEIGHT, R. J. SANTEN, J. D. VELDHUIS, and S. A. WELLS. "EVALUATION OF CALCIUM AS AN INSULIN SECRETAGOGUE IN PATIENTS WITH INSULINOMA." Surgical Forum 35 (January 1, 1984): 49–52.
Cantley, L. K., D. L. Scott, C. W. Cooper, D. D. Mahaffee, G. S. Leight, C. G. Thomas, and D. A. Ontjes. "Divergent effects of forskolin on 3',5' cyclic adenosine monophosphate production and parathyroid hormone secretion.." Calcif Tissue Int 36, no. 1 (January 1984): 87–94. https://doi.org/10.1007/bf02405299.
McCarty, K. S., K. B. Hiatt, D. A. Budwit, E. B. Cox, G. Leight, D. Reintgen, G. Georgiade, and H. F. Siegler. "Clinical response to hormone therapy correlated with estrogen receptor analyses. Biochemical v histochemical methods.." Arch Pathol Lab Med 108, no. 1 (January 1984): 24–26.
Posillico, J. T., G. S. Leight, and N. C. Anderson. "Electrophysiological correlates of secretion in normal human parathyroid cells.." Prog Clin Biol Res 168 (1984): 145–50.
Romanus, M. E., J. A. Neal, W. G. Dilley, G. S. Leight, W. M. Linehan, R. J. Santen, J. R. Farndon, R. S. Jones, and S. A. Wells. "Comparison of four provocative tests for the diagnosis of gastrinoma.." Ann Surg 197, no. 5 (May 1983): 608–17. https://doi.org/10.1097/00000658-198305000-00015.
McCarty, K. S., J. S. Silva, E. B. Cox, G. S. Leight, and S. A. Wells. "Relationship of age and menopausal status to estrogen receptor content in primary carcinoma of the breast.." Ann Surg 197, no. 2 (February 1983): 123–27. https://doi.org/10.1097/00000658-198302000-00001.
Dilley, W. G., G. S. Leight, J. S. Silva, S. Ammirata, D. E. Haagensen, and S. A. Wells. "Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma.." J Natl Cancer Inst 70, no. 1 (January 1983): 69–74.
Silva, J. S., E. B. Cox, and G. S. Leight. "Multivariate analysis of prognostic factors in patients with primary breast carcinoma: Effect of lymph node status, age, menopausal status, and cytosolic estrogen receptor." Surgical Forum VOL. 34 (January 1, 1983): 427–29.
Wells, S. A., S. B. Baylin, G. S. Leight, J. K. Dale, W. G. Dilley, and J. R. Farndon. "The importance of early diagnosis in patients with hereditary medullary thyroid carcinoma.." Ann Surg 195, no. 5 (May 1982): 595–99. https://doi.org/10.1097/00000658-198205000-00008.
Silva, J. S., G. S. Leight, D. E. Haagensen, P. B. Tallos, E. B. Cox, W. G. Dilley, and S. A. Wells. "Quantitation of response to therapy in patients with metastatic breast carcinoma by serial analysis of plasma gross cystic disease fluid protein and carcinoembryonic antigen.." Cancer 49, no. 6 (March 15, 1982): 1236–42. https://doi.org/10.1002/1097-0142(19820315)49:6<1236::aid-cncr2820490627>3.0.co;2-t.
Cantley, L. K., C. W. Cooper, and G. S. Leight. "Stimulation of parathyroid adenylate cyclase by forskolin does not cause stimulation of parathyroid hormone release in human adenomas or rat parathyroids." Calcified Tissue International 34, no. Suppl. 1 (January 1, 1982).
Dilley, W. G., G. S. Leight, and S. A. Wells. "Androgen stimulation of breast cyst fluid antigen levels in plasma of patients with metastatic breast carcinoma." Proceedings of the American Association for Cancer Research Vol. 23 (January 1, 1982).
MCCARTY, K. S., and G. S. LEIGHT. "DETERMINATION OF ESTROGEN-RECEPTOR STATUS." Jama Journal of the American Medical Association 247, no. 3 (January 1, 1982): 367-.
McCarty, K. S., D. E. Nichols, and G. Leight. "Comparison of clinical response to hormone therapy using estrogen receptor analyses by biochemical versus histochemical methods." Laboratory Investigation 46, no. 1 (January 1, 1982).
FARNDON, J. R., P. A. ROUTLEDGE, G. S. LEIGHT, W. G. DILLEY, and S. A. WELLS. "BETA-ADRENERGIC EFFECTS ON PARATHYROID-HORMONE RELEASE." Surgical Forum 32 (January 1, 1981): 28–30.
Farndon, J. R., P. A. Routledge, and G. S. Leight. "Beta-adrenergic effects on parathyroid (PTH) release." British Journal of Surgery 68, no. 11 (January 1, 1981).
Feier, C. D., and G. Leight. "A communication-cognition program for elderly nursing home residents." Gerontologist 21, no. 4 (1981): 408–16.
Haagensen, D. E., J. S. Silva, and G. S. Leight. "Fluoxymesterone stimulates plasma concentrations of gross cystic disease fluid protein in patients with metastatic breast carcinoma." Surgical Forum Vol. 32 (January 1, 1981): 413–14.
ROMANUS, M. E., W. G. DILLEY, G. S. LEIGHT, and S. A. WELLS. "INSULIN RELEASE FROM HUMAN AND HAMSTER INSULINOMAS STIMULATED BY RAPID CALCIUM INFUSION." Surgical Forum 32 (January 1, 1981): 207–9.
Wells, S. A., G. S. Leight, and A. J. Ross. "Primary hyperparathyroidism.." Curr Probl Surg 17, no. 8 (August 1980): 398–463.
Wells, S. A., G. S. Leight, and A. J. Ross. "Primary hyperparathyroidism." Current Problems in Surgery 17, no. 8 (January 1, 1980): 397–463. https://doi.org/10.1016/S0011-3840(80)80006-2.
Wells, S. A., J. R. Farndon, J. K. Dale, G. S. Leight, and W. G. Dilley. "Long-term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation.." Ann Surg 192, no. 4 (1980): 451–58. https://doi.org/10.1097/00000658-198010000-00003.
Sears, H. F., G. A. Parker, S. J. Marx, G. S. Leight, and R. E. Terrill. "Parathyroid autotransplantation: use of cryopreserved glands in an investigation of hypocalcemia.." Cryobiology 16, no. 5 (October 1979): 411–16. https://doi.org/10.1016/0011-2240(79)90053-1.
Kirkman, R. L., R. B. Colvin, M. W. Flye, G. S. Leight, S. A. Rosenberg, G. M. Williams, and D. H. Sachs. "Transplantation in miniature swine. VI. Factors influencing survival of renal allografts.." Transplantation 28, no. 1 (July 1979): 18–23.
Leight, G. S., R. Kirkman, B. A. Rasmusen, S. A. Rosenberg, D. H. Sachs, R. Terrill, and G. M. Williams. "Transplantation in miniature swine. III: effects of MSLA and A-O blood group matching on skin allograft survival.." Tissue Antigens 12, no. 2 (August 1978): 65–74. https://doi.org/10.1111/j.1399-0039.1978.tb01301.x.
Leight, G. S., G. A. Parker, H. F. Sears, S. J. Marx, and R. E. Terrill. "Experimental cryopreservation and autotransplantation of parathyroid glands: technique and demonstration of function.." Ann Surg 188, no. 1 (July 1978): 16–21. https://doi.org/10.1097/00000658-197807000-00002.
Leight, G. S., and L. L. Michaelis. "Open lung biopsy for the diagnosis of acute, diffuse pulmonary infiltrates in the immunosuppressed patient.." Chest 73, no. 4 (April 1978): 477–82. https://doi.org/10.1378/chest.73.4.477.
Leight, G. S., D. H. Sachs, G. M. Williams, and S. A. Rosenberg. "Transplantation in miniature swine.." Transplant Proc 9, no. 1 (March 1977): 575–77.
Leight, G. S., D. H. Sachs, and S. A. Rosenberg. "Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs.." Transplantation 23, no. 3 (March 1977): 271–76.
Sachs, D. H., G. Leight, J. Cone, S. Schwarz, L. Stuart, and S. Rosenberg. "Transplantation in miniature swine. I. Fixation of the major histocompatibility complex.." Transplantation 22, no. 6 (December 1976): 559–67. https://doi.org/10.1097/00007890-197612000-00004.
Michaelis, L. L., G. S. Leight, R. D. Pouell, and V. T. DeVita. "Pneumocystis pneumonia: the importance of early open lung biopsy.." Ann Surg 183, no. 3 (March 1976): 301–6. https://doi.org/10.1097/00000658-197603000-00016.
Jhaver, P. S., J. E. Davis, H. Lee, J. F. Hulka, and G. Leight. "Reversibility of sterilization produced by vas occlusion clip.." Fertil Steril 22, no. 4 (April 1971): 263–69.
Tebbit, C. L., J. Pittman, M. J. Ellis, R. Bentley, H. Dressman, G. Mann, G. S. Leight, J. Nevins, J. R. Marks, and J. A. Olson. "Application of clinico-genomic models that predict breast cancer characteristics in a prospective study." In Annals of Surgical Oncology, 12:S68–S68. SPRINGER, 2005.
Gallagher, Scott F., Daphne W. Denham, Michel M. Murr, and James G. Norman. "The impact of minimally invasive parathyroidectomy on the way endocrinologists treat primary hyperparathyroidism.." In Surgery, 134:910–17, 2003. https://doi.org/10.1016/s0039-6060(03)00414-8.
Miller, K. L., L. B. Marks, R. C. Bentley, R. W. Clough, R. G. Prosnitz, and G. S. Leight. "Does increased sectioning of ductal carcinoma in-situ (DCIS) pathologic specimens have clinical consequences?." In Breast Cancer Research and Treatment, 76:S61–S61, 2002.
White, D. C., A. Hamza, K. Nielson, H. K. Lyerly, S. M. Steele, S. K. Pruitt, G. S. Leight, and J. A. Olson. "Thoracic paravertebral blockade for breast sentinel lymph node biopsy: Experience in 137 patients." In Annals of Surgical Oncology, 9:S56–57. LIPPINCOTT WILLIAMS & WILKINS, 2002.
Garner, S. C., P. Gao, T. Cantor, and G. S. Leight. "Potential of a "whole PTH" assay to improve the discrimination of intraoperative parathyroid hormone assays.." In Journal of Bone and Mineral Research, 15:S482–S482. AMER SOC BONE & MINERAL RES, 2000.
McDermott, V. G., J. J. Norconk, V. S. Lee, H. D. Sostman, G. S. Leight, and C. E. Spritzer. "Parathyroid lesion localization: MR imaging and surgical correlation." In Radiology, 201:602–602. RADIOLOGICAL SOC NORTH AMER, 1996.
Garner, S. C., K. S. McCarthy, and G. S. Leight. "Benefits of intraoperative parathyroid hormone monitoring during surgery for hyperparathyroidism.." In Journal of Bone and Mineral Research, 11:T750–T750. BLACKWELL SCIENCE INC, 1996.
GARNER, S. C., T. K. HINSON, K. S. MCCARTY, G. S. LEIGHT, and L. D. QUARLES. "QUANTITATIVE-ANALYSIS OF THE CALCIUM-SENSING RECEPTOR BY COMPETITIVE RT-PCR." In Journal of Bone and Mineral Research, 10:S487–S487. BLACKWELL SCIENCE PUBL INC CAMBRIDGE, 1995.
LJUNG, B. M., B. H. MAYALL, C. LOTTICH, C. BOYER, G. S. LEIGHT, H. F. SIEGLER, S. S. SYLVESTER, and H. S. SMITH. "TUMOR-CELL VIABILITY IN SUBPOPULATIONS OF HUMAN-BREAST CANCER." In Proceedings of the American Association for Cancer Research, 28:34–34. AMER ASSOC CANCER RESEARCH, 1987.
LJUNG, B. M., B. H. MAYALL, C. LOTTICH, C. BOYER, G. S. LEIGHT, H. F. SIEGLER, S. S. SYLVESTER, and H. S. SMITH. "TUMOR-CELL VIABILITY OF HUMAN-BREAST CANCER." In Breast Cancer Research and Treatment, 10:119–119. KLUWER ACADEMIC PUBL, 1987.
CANTLEY, L. K., C. W. COOPER, G. S. LEIGHT, C. G. THOMAS, and D. A. ONTJES. "FORSKOLIN STIMULATES PARATHYROID ADENYLATE-CYCLASE BUT NOT PARATHYROID-HORMONE RELEASE." In Clinical Research, 30:A387–A387. SLACK INC, 1982.
CANTLEY, L. K., C. W. COOPER, G. S. LEIGHT, and D. A. ONTJES. "THE EFFECTS OF CHOLERA-TOXIN ON HUMAN PARATHYROID-GLAND FUNCTION-INVITRO." In Clinical Research, 30:A877–A877. SLACK INC, 1982.
DILLEY, W. G., G. S. LEIGHT, and S. A. WELLS. "ANDROGEN STIMULATION OF BREAST CYST FLUID ANTIGEN LEVELS IN PLASMA OF PATIENTS WITH METASTATIC BREAST-CARCINOMA." In Proceedings of the American Association for Cancer Research, 23:153–153. AMER ASSOC CANCER RESEARCH, 1982.
FARNDON, J. R., P. A. ROUTLEDGE, G. S. LEIGHT, W. G. DILLEY, and S. A. WELLS. "BETA-ADRENERGIC EFFECTS ON PARATHYROID (PTH) RELEASE." In British Journal of Surgery, 68:821–821. BLACKWELL SCIENCE LTD, 1981.
LEIGHT, G. S., R. E. FARRELL, S. A. WELLS, and J. M. FALLETTA. "EFFECT OF CHEMOTHERAPY ON CALCITONIN (CT) LEVELS IN PATIENTS WITH METASTATIC MEDULLARY-THYROID CARCINOMA (MTC)." In Proceedings of the American Association for Cancer Research, 21:155–155. AMER ASSOC CANCER RESEARCH, 1980.