Embryo development after heterotopic transplantation of cryopreserved ovarian tissue
Kutluk Oktay, Erkan Buyuk, Lucinda Veeck, Nikica Zaninovic, Kangpu Xu, Takumi Takeuchi, Michael Opsahl, Zev Rosenwaks
Obstetrics & Gynecology and Women's Health
Background Cancer treatments, including chemotherapy, radiotherapy, and radical surgery, can induce premature menopause and infertility in hundreds of thousands of women of reproductive age every year. One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue. Methods Ovarian tissue was cryopreserved from a 30-year-old woman with breast cancer before chemotherapy-induced menopause, and this tissue was transplanted beneath the skin of her abdomen 6 years later. Findings Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and oestrogen production. The patient underwent eight oocyte retrievals percutaneously and 20 oocytes were retrieved. Of the eight oocytes suitable for in-vitro fertilisation, one fertilised normally and developed into a four-cell embryo. Interpretation Fertility and ovarian endocrine function can be preserved in women by long-term ovarian tissue banking.
Published - Mar 13 2004
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Heterotopic Transplantation Medicine & Life Sciences
Fertility Medicine & Life Sciences
Embryonic Development Medicine & Life Sciences
Tissue Transplantation Medicine & Life Sciences
Oocytes Medicine & Life Sciences
Premature Menopause Medicine & Life Sciences
Tissue Banks Medicine & Life Sciences
Oocyte Retrieval Medicine & Life Sciences
Oktay, K., Buyuk, E., Veeck, L., Zaninovic, N., Xu, K., Takeuchi, T., Opsahl, M., & Rosenwaks, Z. (2004). Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet, 363(9412), 837-840. https://doi.org/10.1016/S0140-6736(04)15728-0
Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. / Oktay, Kutluk; Buyuk, Erkan; Veeck, Lucinda; Zaninovic, Nikica; Xu, Kangpu; Takeuchi, Takumi; Opsahl, Michael; Rosenwaks, Zev.
In: Lancet, Vol. 363, No. 9412, 13.03.2004, p. 837-840.
Oktay, K, Buyuk, E, Veeck, L, Zaninovic, N, Xu, K, Takeuchi, T, Opsahl, M & Rosenwaks, Z 2004, 'Embryo development after heterotopic transplantation of cryopreserved ovarian tissue', Lancet, vol. 363, no. 9412, pp. 837-840. https://doi.org/10.1016/S0140-6736(04)15728-0
Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004 Mar 13;363(9412):837-840. https://doi.org/10.1016/S0140-6736(04)15728-0
Oktay, Kutluk ; Buyuk, Erkan ; Veeck, Lucinda ; Zaninovic, Nikica ; Xu, Kangpu ; Takeuchi, Takumi ; Opsahl, Michael ; Rosenwaks, Zev. / Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. In: Lancet. 2004 ; Vol. 363, No. 9412. pp. 837-840.
@article{3927adade6334e11a3fa04347b6c972e,
title = "Embryo development after heterotopic transplantation of cryopreserved ovarian tissue",
abstract = "Background Cancer treatments, including chemotherapy, radiotherapy, and radical surgery, can induce premature menopause and infertility in hundreds of thousands of women of reproductive age every year. One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue. Methods Ovarian tissue was cryopreserved from a 30-year-old woman with breast cancer before chemotherapy-induced menopause, and this tissue was transplanted beneath the skin of her abdomen 6 years later. Findings Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and oestrogen production. The patient underwent eight oocyte retrievals percutaneously and 20 oocytes were retrieved. Of the eight oocytes suitable for in-vitro fertilisation, one fertilised normally and developed into a four-cell embryo. Interpretation Fertility and ovarian endocrine function can be preserved in women by long-term ovarian tissue banking.",
author = "Kutluk Oktay and Erkan Buyuk and Lucinda Veeck and Nikica Zaninovic and Kangpu Xu and Takumi Takeuchi and Michael Opsahl and Zev Rosenwaks",
journal = "The Lancet",
publisher = "Elsevier Limited",
T1 - Embryo development after heterotopic transplantation of cryopreserved ovarian tissue
AU - Oktay, Kutluk
AU - Buyuk, Erkan
AU - Veeck, Lucinda
AU - Zaninovic, Nikica
AU - Xu, Kangpu
AU - Takeuchi, Takumi
AU - Opsahl, Michael
AU - Rosenwaks, Zev
N2 - Background Cancer treatments, including chemotherapy, radiotherapy, and radical surgery, can induce premature menopause and infertility in hundreds of thousands of women of reproductive age every year. One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue. Methods Ovarian tissue was cryopreserved from a 30-year-old woman with breast cancer before chemotherapy-induced menopause, and this tissue was transplanted beneath the skin of her abdomen 6 years later. Findings Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and oestrogen production. The patient underwent eight oocyte retrievals percutaneously and 20 oocytes were retrieved. Of the eight oocytes suitable for in-vitro fertilisation, one fertilised normally and developed into a four-cell embryo. Interpretation Fertility and ovarian endocrine function can be preserved in women by long-term ovarian tissue banking.
AB - Background Cancer treatments, including chemotherapy, radiotherapy, and radical surgery, can induce premature menopause and infertility in hundreds of thousands of women of reproductive age every year. One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplantation of ovarian tissue. Methods Ovarian tissue was cryopreserved from a 30-year-old woman with breast cancer before chemotherapy-induced menopause, and this tissue was transplanted beneath the skin of her abdomen 6 years later. Findings Ovarian function returned in the patient 3 months after transplantation, as shown by follicle development and oestrogen production. The patient underwent eight oocyte retrievals percutaneously and 20 oocytes were retrieved. Of the eight oocytes suitable for in-vitro fertilisation, one fertilised normally and developed into a four-cell embryo. Interpretation Fertility and ovarian endocrine function can be preserved in women by long-term ovarian tissue banking.
JO - The Lancet
JF - The Lancet