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Risk factors for peritoneal dissemination of colorectal cancer
Shung Haur Yang*, Jen Kou Lin, Chiung Ru Lai, Chien Chih Chen, Fen Yau A. Li, Wen Yih Liang, Jeng Kae Jiang
Background and Objectives: The aim of this study was to clarify the risk factors associated with positive peritoneal dissemination (PPD) of colorectal cancer (CRC). Methods: From June 2000 to September 2002, 143 CRC patients who underwent elective curative (79.0%) or non-curative (21.0%) open laparotomy were prospectively studied. Clinical evaluations including classical factors, colonoscopic evaluation, intraoperative evaluation, and pathological features were recorded. PPD was diagnosed when macro- (MAPD) or microscopic peritoneal dissemination (MIPD) was evident. Positive peritoneal cytology from initially existing ascites or washing lavage indicated MIPD. Various factors were analyzed with univariate (Chi-square test) and then multivariate analyses (logistic regression test) to search for the risk factors of PPD. Results: Overall, MIPD, MAPD, and PPD were found in 2.8%, 6.3%, and 9.1%, respectively. Univariate analysis identified age (≤59 years), CA19-9 (≥34.6 U/ml), poor differentiation, circumferential involvement (≥3 quadrants), ascites volume (>80 ml), pN+, and pT4 as risk factors of PPD. PPD did not occur in patients with well-differentiated tumors, less circumferential involvement (<2 quadrants), or no lymph node metastasis. After multivariate analysis, CA19-9 (Odds ratio (95% CI), 8.6 (1.7-43.1)), pT4 (9.0 (1.3-61.0)), and age (5.26 (1.1-25.0)) remained significant risk factors. Conclusion: CA19-9 (≥34.6 U/ml), pT4, and age (≤59 years) were significant risk factors of PPD.
Journal of Surgical Oncology
https://doi.org/10.1002/jso.20109
Peritoneal dissemination
10.1002/jso.20109
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Colorectal Neoplasms Medicine & Life Sciences 100%
Ascites Medicine & Life Sciences 49%
Therapeutic Irrigation Medicine & Life Sciences 28%
Laparotomy Medicine & Life Sciences 23%
Cell Biology Medicine & Life Sciences 21%
Lymph Nodes Medicine & Life Sciences 17%
Neoplasms Medicine & Life Sciences 8%
Yang, S. H., Lin, J. K., Lai, C. R., Chen, C. C., Li, F. Y. A., Liang, W. Y., & Jiang, J. K. (2004). Risk factors for peritoneal dissemination of colorectal cancer. Journal of Surgical Oncology, 87(4), 167-173. https://doi.org/10.1002/jso.20109
Yang, Shung Haur ; Lin, Jen Kou ; Lai, Chiung Ru et al. / Risk factors for peritoneal dissemination of colorectal cancer. In: Journal of Surgical Oncology. 2004 ; Vol. 87, No. 4. pp. 167-173.
@article{a324554e688c49e1b6d8b6823556a834,
title = "Risk factors for peritoneal dissemination of colorectal cancer",
abstract = "Background and Objectives: The aim of this study was to clarify the risk factors associated with positive peritoneal dissemination (PPD) of colorectal cancer (CRC). Methods: From June 2000 to September 2002, 143 CRC patients who underwent elective curative (79.0%) or non-curative (21.0%) open laparotomy were prospectively studied. Clinical evaluations including classical factors, colonoscopic evaluation, intraoperative evaluation, and pathological features were recorded. PPD was diagnosed when macro- (MAPD) or microscopic peritoneal dissemination (MIPD) was evident. Positive peritoneal cytology from initially existing ascites or washing lavage indicated MIPD. Various factors were analyzed with univariate (Chi-square test) and then multivariate analyses (logistic regression test) to search for the risk factors of PPD. Results: Overall, MIPD, MAPD, and PPD were found in 2.8%, 6.3%, and 9.1%, respectively. Univariate analysis identified age (≤59 years), CA19-9 (≥34.6 U/ml), poor differentiation, circumferential involvement (≥3 quadrants), ascites volume (>80 ml), pN+, and pT4 as risk factors of PPD. PPD did not occur in patients with well-differentiated tumors, less circumferential involvement (<2 quadrants), or no lymph node metastasis. After multivariate analysis, CA19-9 (Odds ratio (95% CI), 8.6 (1.7-43.1)), pT4 (9.0 (1.3-61.0)), and age (5.26 (1.1-25.0)) remained significant risk factors. Conclusion: CA19-9 (≥34.6 U/ml), pT4, and age (≤59 years) were significant risk factors of PPD.",
keywords = "Colorectal cancer, Cytology, Peritoneal dissemination, Risk factors",
author = "Yang, {Shung Haur} and Lin, {Jen Kou} and Lai, {Chiung Ru} and Chen, {Chien Chih} and Li, {Fen Yau A.} and Liang, {Wen Yih} and Jiang, {Jeng Kae}",
doi = "10.1002/jso.20109",
journal = "Journal of Surgical Oncology",
publisher = "Wiley-Liss Inc.",
Yang, SH, Lin, JK, Lai, CR, Chen, CC, Li, FYA, Liang, WY & Jiang, JK 2004, 'Risk factors for peritoneal dissemination of colorectal cancer', Journal of Surgical Oncology, vol. 87, no. 4, pp. 167-173. https://doi.org/10.1002/jso.20109
Risk factors for peritoneal dissemination of colorectal cancer. / Yang, Shung Haur; Lin, Jen Kou; Lai, Chiung Ru et al.
In: Journal of Surgical Oncology, Vol. 87, No. 4, 15.09.2004, p. 167-173.
T1 - Risk factors for peritoneal dissemination of colorectal cancer
AU - Yang, Shung Haur
AU - Lin, Jen Kou
AU - Lai, Chiung Ru
AU - Chen, Chien Chih
AU - Li, Fen Yau A.
AU - Liang, Wen Yih
AU - Jiang, Jeng Kae
N2 - Background and Objectives: The aim of this study was to clarify the risk factors associated with positive peritoneal dissemination (PPD) of colorectal cancer (CRC). Methods: From June 2000 to September 2002, 143 CRC patients who underwent elective curative (79.0%) or non-curative (21.0%) open laparotomy were prospectively studied. Clinical evaluations including classical factors, colonoscopic evaluation, intraoperative evaluation, and pathological features were recorded. PPD was diagnosed when macro- (MAPD) or microscopic peritoneal dissemination (MIPD) was evident. Positive peritoneal cytology from initially existing ascites or washing lavage indicated MIPD. Various factors were analyzed with univariate (Chi-square test) and then multivariate analyses (logistic regression test) to search for the risk factors of PPD. Results: Overall, MIPD, MAPD, and PPD were found in 2.8%, 6.3%, and 9.1%, respectively. Univariate analysis identified age (≤59 years), CA19-9 (≥34.6 U/ml), poor differentiation, circumferential involvement (≥3 quadrants), ascites volume (>80 ml), pN+, and pT4 as risk factors of PPD. PPD did not occur in patients with well-differentiated tumors, less circumferential involvement (<2 quadrants), or no lymph node metastasis. After multivariate analysis, CA19-9 (Odds ratio (95% CI), 8.6 (1.7-43.1)), pT4 (9.0 (1.3-61.0)), and age (5.26 (1.1-25.0)) remained significant risk factors. Conclusion: CA19-9 (≥34.6 U/ml), pT4, and age (≤59 years) were significant risk factors of PPD.
AB - Background and Objectives: The aim of this study was to clarify the risk factors associated with positive peritoneal dissemination (PPD) of colorectal cancer (CRC). Methods: From June 2000 to September 2002, 143 CRC patients who underwent elective curative (79.0%) or non-curative (21.0%) open laparotomy were prospectively studied. Clinical evaluations including classical factors, colonoscopic evaluation, intraoperative evaluation, and pathological features were recorded. PPD was diagnosed when macro- (MAPD) or microscopic peritoneal dissemination (MIPD) was evident. Positive peritoneal cytology from initially existing ascites or washing lavage indicated MIPD. Various factors were analyzed with univariate (Chi-square test) and then multivariate analyses (logistic regression test) to search for the risk factors of PPD. Results: Overall, MIPD, MAPD, and PPD were found in 2.8%, 6.3%, and 9.1%, respectively. Univariate analysis identified age (≤59 years), CA19-9 (≥34.6 U/ml), poor differentiation, circumferential involvement (≥3 quadrants), ascites volume (>80 ml), pN+, and pT4 as risk factors of PPD. PPD did not occur in patients with well-differentiated tumors, less circumferential involvement (<2 quadrants), or no lymph node metastasis. After multivariate analysis, CA19-9 (Odds ratio (95% CI), 8.6 (1.7-43.1)), pT4 (9.0 (1.3-61.0)), and age (5.26 (1.1-25.0)) remained significant risk factors. Conclusion: CA19-9 (≥34.6 U/ml), pT4, and age (≤59 years) were significant risk factors of PPD.
KW - Colorectal cancer
KW - Cytology
KW - Peritoneal dissemination
U2 - 10.1002/jso.20109
DO - 10.1002/jso.20109
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
Yang SH, Lin JK, Lai CR, Chen CC, Li FYA, Liang WY et al. Risk factors for peritoneal dissemination of colorectal cancer. Journal of Surgical Oncology. 2004 Sep 15;87(4):167-173. doi: 10.1002/jso.20109