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Merck Acquires Grzybowski Scientific Inventions to Expand Chemical Synthesis Offering
Revolutionary computer-aided retro-synthesis software optimizes productivity, organic synthesis
Complements Merck's leading e-commerce platform and chemistry portfolio of more than 400,000 building blocks, catalysts and reagents for chemical synthesis
Darmstadt, Germany, May 9, 2017 — Merck, a leading science and technology company, today announced the acquisition of Grzybowski Scientific Inventions (GSI), a company that developed the revolutionary computer-aided retro-synthesis tool, Chematica. Chematica uses advanced reaction rules and proprietary algorithms to identify synthesis pathways that meet user-defined constraints. Financial details of the transaction were not disclosed.
"With a 350-year legacy in the pharmaceutical and chemistry business, we recognize the attractiveness of the chemical synthesis and cheminformatics market and how it complements our existing leadership position in chemicals and reagents," said Udit Batra, Member of the Merck Executive Board and CEO, Life Science.
Virtual synthesis significantly reduces the time between chemical target conception and route evaluation by using a lab's preferences to filter millions of data points. The tool quickly and efficiently provides optimized routes, providing significant benefit to all researchers, especially those working in medicinal chemistry and drug discovery.
GSI's knowledge base of tens of thousands of expert-defined rules of chemical reactivity, combined with proprietary algorithms, enables the program to scrutinize millions of synthetic pathways and to choose the routes that lead to desired targets in the most cost-effective way.
"As chemists who grew up with Sigma-Aldrich and Millipore in the lab, we couldn't be more proud to be acquired by a company with such a long legacy and sincere interest in chemistry," said Bartosz Grzybowski, founder of GSI and inventor of Chematica. "Combining our revolutionary planning tool with Merck's large number of available starting materials, and its industry leading e-commerce platform, will provide immense value to our customers."
The Chematica tool is available now through a limited release for users in academia and in industry.
About Grzybowski Scientific Inventions (GSI)
Grzybowski Scientific Inventions (GSI) is a start-up company with exclusive licensing, development, marketing and sales rights to the revolutionary chemistry decision-making and synthetic planning software product Chematica. Since its establishment in December 2013, GSI has successfully engaged a clientele composed of a wide range of industries as well as academic and government institutions from all over the world. Today, Chematica is widely recognized as the first computer program capable of "chemical thinking" and the only expert system able to design chemically viable synthetic pathways for complex targets – including drugs, natural products as well as theoretical molecules – within seconds.
About Merck
Merck, a leading science and technology company, operates across healthcare, life science and performance materials. Around 57,000 employees work to make a positive difference to millions of people's lives every day by creating more joyful and sustainable ways to live. From advancing gene editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2019, Merck generated sales of €16.2 billion in 66 countries.
Scientific exploration and responsible entrepreneurship have been key to Merck's technological and scientific advances. This is how Merck has thrived since its founding in 1668. The founding family remains the majority owner of the publicly listed company. Merck holds the global rights to the Merck name and brand. The only exceptions are the United States and Canada, where the business sectors of Merck operate as EMD Serono in healthcare, MilliporeSigma in life science and EMD Performance Materials.