Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex
Masashi Niimi, Yutaka Nakai, Yoko Aida
cDNA clones encoding the bovine major histocompatility complex (MHC) class II DM α- and β-chains were isolated and characterized. The BoLA-DMA cDNA clone, MA7, encoded a primary translated product of 260 amino acids, which included a signal peptide of 26 amino acids and a mature polypeptide of 234 amino acids. The BoLA-DMB cDNA clone, MB6, encoded a primary translated product of 262 amino acids, with a signal peptide of 18 amino acids and a mature polypeptide of 244 amino acids. Comparison of the sequences and construction of a phylogenetic tree revealed that both clones are more closely related to human and mouse DM genes than to genes for conventional bovine class II α- and β-chains. Thus, since the bovine DMA and DMB genes are so different from other class II sequences and show evidence of strong conservation (>70%) among the bovine, mouse and human homologues, it seems likely that each of these cDNA clones encodes a functional product, which might perform an important function, as previously established in studies in mouse and man.
https://doi.org/10.1006/bbrc.1995.2807
10.1006/bbrc.1995.2807
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Amino Acids Agricultural and Biological Sciences 100%
Amino Acid Medicine and Dentistry 100%
Genes Agricultural and Biological Sciences 66%
Complementary DNA Medicine and Dentistry 66%
Gene Medicine and Dentistry 66%
Nested Gene Biochemistry, Genetics and Molecular Biology 66%
Molecular Cloning Biochemistry, Genetics and Molecular Biology 66%
Mice Agricultural and Biological Sciences 50%
Niimi, M., Nakai, Y., & Aida, Y. (1995). Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex. Biochemical and biophysical research communications, 217(2), 522-528. https://doi.org/10.1006/bbrc.1995.2807
Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex. / Niimi, Masashi; Nakai, Yutaka; Aida, Yoko.
In: Biochemical and biophysical research communications, Vol. 217, No. 2, 14.12.1995, p. 522-528.
Niimi, M, Nakai, Y & Aida, Y 1995, 'Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex', Biochemical and biophysical research communications, vol. 217, no. 2, pp. 522-528. https://doi.org/10.1006/bbrc.1995.2807
Niimi M, Nakai Y, Aida Y. Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex. Biochemical and biophysical research communications. 1995 Dec 14;217(2):522-528. doi: 10.1006/bbrc.1995.2807
Niimi, Masashi ; Nakai, Yutaka ; Aida, Yoko. / Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex. In: Biochemical and biophysical research communications. 1995 ; Vol. 217, No. 2. pp. 522-528.
@article{3784ff76c54c42bca4d85c600a5823d1,
title = "Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex",
abstract = "cDNA clones encoding the bovine major histocompatility complex (MHC) class II DM α- and β-chains were isolated and characterized. The BoLA-DMA cDNA clone, MA7, encoded a primary translated product of 260 amino acids, which included a signal peptide of 26 amino acids and a mature polypeptide of 234 amino acids. The BoLA-DMB cDNA clone, MB6, encoded a primary translated product of 262 amino acids, with a signal peptide of 18 amino acids and a mature polypeptide of 244 amino acids. Comparison of the sequences and construction of a phylogenetic tree revealed that both clones are more closely related to human and mouse DM genes than to genes for conventional bovine class II α- and β-chains. Thus, since the bovine DMA and DMB genes are so different from other class II sequences and show evidence of strong conservation (>70%) among the bovine, mouse and human homologues, it seems likely that each of these cDNA clones encodes a functional product, which might perform an important function, as previously established in studies in mouse and man.",
author = "Masashi Niimi and Yutaka Nakai and Yoko Aida",
doi = "10.1006/bbrc.1995.2807",
journal = "Biochemical and Biophysical Research Communications",
T1 - Nucleotide sequences and the molecular evolution of the DMA and DMB genes of the bovine major histocompatibility complex
AU - Niimi, Masashi
AU - Nakai, Yutaka
AU - Aida, Yoko
N2 - cDNA clones encoding the bovine major histocompatility complex (MHC) class II DM α- and β-chains were isolated and characterized. The BoLA-DMA cDNA clone, MA7, encoded a primary translated product of 260 amino acids, which included a signal peptide of 26 amino acids and a mature polypeptide of 234 amino acids. The BoLA-DMB cDNA clone, MB6, encoded a primary translated product of 262 amino acids, with a signal peptide of 18 amino acids and a mature polypeptide of 244 amino acids. Comparison of the sequences and construction of a phylogenetic tree revealed that both clones are more closely related to human and mouse DM genes than to genes for conventional bovine class II α- and β-chains. Thus, since the bovine DMA and DMB genes are so different from other class II sequences and show evidence of strong conservation (>70%) among the bovine, mouse and human homologues, it seems likely that each of these cDNA clones encodes a functional product, which might perform an important function, as previously established in studies in mouse and man.
AB - cDNA clones encoding the bovine major histocompatility complex (MHC) class II DM α- and β-chains were isolated and characterized. The BoLA-DMA cDNA clone, MA7, encoded a primary translated product of 260 amino acids, which included a signal peptide of 26 amino acids and a mature polypeptide of 234 amino acids. The BoLA-DMB cDNA clone, MB6, encoded a primary translated product of 262 amino acids, with a signal peptide of 18 amino acids and a mature polypeptide of 244 amino acids. Comparison of the sequences and construction of a phylogenetic tree revealed that both clones are more closely related to human and mouse DM genes than to genes for conventional bovine class II α- and β-chains. Thus, since the bovine DMA and DMB genes are so different from other class II sequences and show evidence of strong conservation (>70%) among the bovine, mouse and human homologues, it seems likely that each of these cDNA clones encodes a functional product, which might perform an important function, as previously established in studies in mouse and man.
U2 - 10.1006/bbrc.1995.2807
DO - 10.1006/bbrc.1995.2807
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications