Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules
Azad A. Jabiev, Marcos H. Ikeda, Isildinha Reis, Carmen C. Solorzano, John Lew
Introduction: Certain surgeon-performed ultrasound (SUS) features may predict differentiated thyroid cancer (DTC). The purpose of this study was to determine the SUS characteristics that are strongly associated with DTC in patients with solitary thyroid nodules. Methods: A retrospective review of 115 patients with solitary thyroid nodules who had SUS before thyroid surgery was performed. Patients were subdivided into two groups based on final pathology results: patients with DTC(n = 61) and those with benign disease (BD) (n = 54). SUS characteristics of thyroid nodules were studied, including size, type, calcifications, borders, shape, and echogenicity. For SUS features, odds ratio (OR), confidence interval (CI), and P values are presented. Results: Of 115 operated patients with solitary thyroid nodules, 53% (61/115) had DTC [papillary, 59%; follicular variant/papillary, 34%; Hürthle cell, 5%; and follicular, 2%] and 47% (54/115) had BD [hyperplastic, 56%; follicular adenoma, 31%; lymphocytic thyroiditis, 7%; and Hürthle cell adenoma, 6%]. Univariate analysis showed that hypoechogenicity, irregular borders, and microcalcifications were associated with an increased risk for DTC compared to hyper/isoechogenicity, regular borders, and coarse/no calcifications. Association strength was confirmed using a multivariate model, including the five SUS characteristics. Hypoechogenicity (OR = 4.27; 95% CI, 1.74-10.47; P < 0.002), irregular borders (OR = 3.10; 95% CI, 1.25-7.7; P < 0.015), and microcalcifications (OR = 2.65; 95%CI, 1.04-6.76; P < 0.05) had a greater association with DTC after adjustment for the other four SUS features. Additionally, the combination of hypoechogenicity, irregular borders, and microcalcifications had the strongest association with DTC (OR = 30.1; 95% CI, 7.76-119.2; P < 0.0001). Conclusions: Hypoechogenicity, irregular borders, and microcalcifications were most strongly associated with an increased risk for DTC. These SUS characteristics may have additional clinical value in predicting DTC in patients with solitary thyroid nodules.
Thyroid Nodule
Thyroid Neoplasms
Calcinosis
Autoimmune Thyroiditis
Jabiev, A. A., Ikeda, M. H., Reis, I., Solorzano, C. C., & Lew, J. (2009). Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules. Annals of Surgical Oncology, 16(11), 3140-3145. https://doi.org/10.1245/s10434-009-0652-9
Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules. / Jabiev, Azad A.; Ikeda, Marcos H.; Reis, Isildinha; Solorzano, Carmen C.; Lew, John.
In: Annals of Surgical Oncology, Vol. 16, No. 11, 01.11.2009, p. 3140-3145.
Jabiev, AA, Ikeda, MH, Reis, I, Solorzano, CC & Lew, J 2009, 'Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules', Annals of Surgical Oncology, vol. 16, no. 11, pp. 3140-3145. https://doi.org/10.1245/s10434-009-0652-9
Jabiev AA, Ikeda MH, Reis I, Solorzano CC, Lew J. Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules. Annals of Surgical Oncology. 2009 Nov 1;16(11):3140-3145. https://doi.org/10.1245/s10434-009-0652-9
Jabiev, Azad A. ; Ikeda, Marcos H. ; Reis, Isildinha ; Solorzano, Carmen C. ; Lew, John. / Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules. In: Annals of Surgical Oncology. 2009 ; Vol. 16, No. 11. pp. 3140-3145.
@article{375d908bbb7a4767972617e39c048f0c,
title = "Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules",
abstract = "Introduction: Certain surgeon-performed ultrasound (SUS) features may predict differentiated thyroid cancer (DTC). The purpose of this study was to determine the SUS characteristics that are strongly associated with DTC in patients with solitary thyroid nodules. Methods: A retrospective review of 115 patients with solitary thyroid nodules who had SUS before thyroid surgery was performed. Patients were subdivided into two groups based on final pathology results: patients with DTC(n = 61) and those with benign disease (BD) (n = 54). SUS characteristics of thyroid nodules were studied, including size, type, calcifications, borders, shape, and echogenicity. For SUS features, odds ratio (OR), confidence interval (CI), and P values are presented. Results: Of 115 operated patients with solitary thyroid nodules, 53{\%} (61/115) had DTC [papillary, 59{\%}; follicular variant/papillary, 34{\%}; H{\"u}rthle cell, 5{\%}; and follicular, 2{\%}] and 47{\%} (54/115) had BD [hyperplastic, 56{\%}; follicular adenoma, 31{\%}; lymphocytic thyroiditis, 7{\%}; and H{\"u}rthle cell adenoma, 6{\%}]. Univariate analysis showed that hypoechogenicity, irregular borders, and microcalcifications were associated with an increased risk for DTC compared to hyper/isoechogenicity, regular borders, and coarse/no calcifications. Association strength was confirmed using a multivariate model, including the five SUS characteristics. Hypoechogenicity (OR = 4.27; 95{\%} CI, 1.74-10.47; P < 0.002), irregular borders (OR = 3.10; 95{\%} CI, 1.25-7.7; P < 0.015), and microcalcifications (OR = 2.65; 95{\%}CI, 1.04-6.76; P < 0.05) had a greater association with DTC after adjustment for the other four SUS features. Additionally, the combination of hypoechogenicity, irregular borders, and microcalcifications had the strongest association with DTC (OR = 30.1; 95{\%} CI, 7.76-119.2; P < 0.0001). Conclusions: Hypoechogenicity, irregular borders, and microcalcifications were most strongly associated with an increased risk for DTC. These SUS characteristics may have additional clinical value in predicting DTC in patients with solitary thyroid nodules.",
author = "Jabiev, {Azad A.} and Ikeda, {Marcos H.} and Isildinha Reis and Solorzano, {Carmen C.} and John Lew",
journal = "Annals of Surgical Oncology",
T1 - Surgeon-performed ultrasound can predict differentiated thyroid cancer in patients with solitary thyroid nodules
AU - Jabiev, Azad A.
AU - Ikeda, Marcos H.
AU - Reis, Isildinha
AU - Solorzano, Carmen C.
AU - Lew, John
N2 - Introduction: Certain surgeon-performed ultrasound (SUS) features may predict differentiated thyroid cancer (DTC). The purpose of this study was to determine the SUS characteristics that are strongly associated with DTC in patients with solitary thyroid nodules. Methods: A retrospective review of 115 patients with solitary thyroid nodules who had SUS before thyroid surgery was performed. Patients were subdivided into two groups based on final pathology results: patients with DTC(n = 61) and those with benign disease (BD) (n = 54). SUS characteristics of thyroid nodules were studied, including size, type, calcifications, borders, shape, and echogenicity. For SUS features, odds ratio (OR), confidence interval (CI), and P values are presented. Results: Of 115 operated patients with solitary thyroid nodules, 53% (61/115) had DTC [papillary, 59%; follicular variant/papillary, 34%; Hürthle cell, 5%; and follicular, 2%] and 47% (54/115) had BD [hyperplastic, 56%; follicular adenoma, 31%; lymphocytic thyroiditis, 7%; and Hürthle cell adenoma, 6%]. Univariate analysis showed that hypoechogenicity, irregular borders, and microcalcifications were associated with an increased risk for DTC compared to hyper/isoechogenicity, regular borders, and coarse/no calcifications. Association strength was confirmed using a multivariate model, including the five SUS characteristics. Hypoechogenicity (OR = 4.27; 95% CI, 1.74-10.47; P < 0.002), irregular borders (OR = 3.10; 95% CI, 1.25-7.7; P < 0.015), and microcalcifications (OR = 2.65; 95%CI, 1.04-6.76; P < 0.05) had a greater association with DTC after adjustment for the other four SUS features. Additionally, the combination of hypoechogenicity, irregular borders, and microcalcifications had the strongest association with DTC (OR = 30.1; 95% CI, 7.76-119.2; P < 0.0001). Conclusions: Hypoechogenicity, irregular borders, and microcalcifications were most strongly associated with an increased risk for DTC. These SUS characteristics may have additional clinical value in predicting DTC in patients with solitary thyroid nodules.
AB - Introduction: Certain surgeon-performed ultrasound (SUS) features may predict differentiated thyroid cancer (DTC). The purpose of this study was to determine the SUS characteristics that are strongly associated with DTC in patients with solitary thyroid nodules. Methods: A retrospective review of 115 patients with solitary thyroid nodules who had SUS before thyroid surgery was performed. Patients were subdivided into two groups based on final pathology results: patients with DTC(n = 61) and those with benign disease (BD) (n = 54). SUS characteristics of thyroid nodules were studied, including size, type, calcifications, borders, shape, and echogenicity. For SUS features, odds ratio (OR), confidence interval (CI), and P values are presented. Results: Of 115 operated patients with solitary thyroid nodules, 53% (61/115) had DTC [papillary, 59%; follicular variant/papillary, 34%; Hürthle cell, 5%; and follicular, 2%] and 47% (54/115) had BD [hyperplastic, 56%; follicular adenoma, 31%; lymphocytic thyroiditis, 7%; and Hürthle cell adenoma, 6%]. Univariate analysis showed that hypoechogenicity, irregular borders, and microcalcifications were associated with an increased risk for DTC compared to hyper/isoechogenicity, regular borders, and coarse/no calcifications. Association strength was confirmed using a multivariate model, including the five SUS characteristics. Hypoechogenicity (OR = 4.27; 95% CI, 1.74-10.47; P < 0.002), irregular borders (OR = 3.10; 95% CI, 1.25-7.7; P < 0.015), and microcalcifications (OR = 2.65; 95%CI, 1.04-6.76; P < 0.05) had a greater association with DTC after adjustment for the other four SUS features. Additionally, the combination of hypoechogenicity, irregular borders, and microcalcifications had the strongest association with DTC (OR = 30.1; 95% CI, 7.76-119.2; P < 0.0001). Conclusions: Hypoechogenicity, irregular borders, and microcalcifications were most strongly associated with an increased risk for DTC. These SUS characteristics may have additional clinical value in predicting DTC in patients with solitary thyroid nodules.
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology