Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome
Jung Rae Cho, Sanghoon Shin, Jung Sun Kim, Young Guk Ko, Myeong Ki Hong, Yangsoo Jang, Ki Bae Seung, Hun Sik Park, Seung Jea Tahk, Do Sun Lim, Dong Wun Jeon, In Ho Chae, Duk Kyung Kim, Junghan Yoon, Myung Ho Jeong, Donghoon Choi
Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M:F=297:231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.
Korean Circulation Journal
https://doi.org/10.4070/kcj.2012.42.8.528
Published - 2012 Aug
10.4070/kcj.2012.42.8.528
Dive into the research topics of 'Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome'. Together they form a unique fingerprint.
Acute Aortic Syndrome Medicine and Dentistry 100%
Prospective Study Pharmacology, Toxicology and Pharmaceutical Science 27%
Follow up Medicine and Dentistry 18%
Hematoma Medicine and Dentistry 18%
Venous Ulcer Medicine and Dentistry 18%
Aortic Dissection Medicine and Dentistry 18%
Therapeutic Procedure Medicine and Dentistry 18%
Cho, J. R., Shin, S., Kim, J. S., Ko, Y. G., Hong, M. K., Jang, Y., Seung, K. B., Park, H. S., Tahk, S. J., Lim, D. S., Jeon, D. W., Chae, I. H., Kim, D. K., Yoon, J., Jeong, M. H., & Choi, D. (2012). Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome. Korean Circulation Journal, 42(8), 528-537. https://doi.org/10.4070/kcj.2012.42.8.528
Cho, Jung Rae ; Shin, Sanghoon ; Kim, Jung Sun et al. / Clinical characteristics of Acute Aortic syndrome in Korean patients : From the Korean Multi-Center Registry of Acute Aortic syndrome. In: Korean Circulation Journal. 2012 ; Vol. 42, No. 8. pp. 528-537.
@article{74efa09294b74e2abc8353a5dd0aa66f,
title = "Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome",
abstract = "Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M:F=297:231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.",
author = "Cho, {Jung Rae} and Sanghoon Shin and Kim, {Jung Sun} and Ko, {Young Guk} and Hong, {Myeong Ki} and Yangsoo Jang and Seung, {Ki Bae} and Park, {Hun Sik} and Tahk, {Seung Jea} and Lim, {Do Sun} and Jeon, {Dong Wun} and Chae, {In Ho} and Kim, {Duk Kyung} and Junghan Yoon and Jeong, {Myung Ho} and Donghoon Choi",
doi = "10.4070/kcj.2012.42.8.528",
journal = "Korean Circulation Journal",
publisher = "Korean Society of Circulation",
Cho, JR, Shin, S, Kim, JS, Ko, YG, Hong, MK, Jang, Y, Seung, KB, Park, HS, Tahk, SJ, Lim, DS, Jeon, DW, Chae, IH, Kim, DK, Yoon, J, Jeong, MH & Choi, D 2012, 'Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome', Korean Circulation Journal, vol. 42, no. 8, pp. 528-537. https://doi.org/10.4070/kcj.2012.42.8.528
Clinical characteristics of Acute Aortic syndrome in Korean patients : From the Korean Multi-Center Registry of Acute Aortic syndrome. / Cho, Jung Rae; Shin, Sanghoon; Kim, Jung Sun et al.
In: Korean Circulation Journal, Vol. 42, No. 8, 08.2012, p. 528-537.
T1 - Clinical characteristics of Acute Aortic syndrome in Korean patients
T2 - From the Korean Multi-Center Registry of Acute Aortic syndrome
AU - Cho, Jung Rae
AU - Shin, Sanghoon
AU - Kim, Jung Sun
AU - Ko, Young Guk
AU - Hong, Myeong Ki
AU - Jang, Yangsoo
AU - Seung, Ki Bae
AU - Park, Hun Sik
AU - Tahk, Seung Jea
AU - Lim, Do Sun
AU - Jeon, Dong Wun
AU - Chae, In Ho
AU - Kim, Duk Kyung
AU - Yoon, Junghan
AU - Choi, Donghoon
N2 - Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M:F=297:231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.
AB - Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M:F=297:231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.
U2 - 10.4070/kcj.2012.42.8.528
DO - 10.4070/kcj.2012.42.8.528
JO - Korean Circulation Journal
JF - Korean Circulation Journal
Cho JR, Shin S, Kim JS, Ko YG, Hong MK, Jang Y et al. Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome. Korean Circulation Journal. 2012 Aug;42(8):528-537. doi: 10.4070/kcj.2012.42.8.528