Pew Biomedical Scholars /
Directory of Scholars /
Katherine A. Jones, Ph.D.
Regulatory Biology Laboratory
10010 North Torrey Pines Road
http://www.salk.edu/faculty/kjones.html
Our laboratory is interested in the transcriptional mechanisms responsible for rapid induction of mammalian genes. We are currently focused on the control of RNAPII elongation at the HIV-1 promoter by the HIV-1 Tat protein, which acts through an RNA element to recruit the host cell P-TEFb (CycT1:CDK9) elongation factor. We recently found that an alternative splicing factor, SKIP, also regulates RNAPII transcription elongation. SKIP associates with P-TEFb and is required for Tat activation, and current studies are seeking to identify how SKIP and associated factors control transcription elongation at HIV-1 and cellular genes. We are also examining how non-coding regulatory RNAs control transcription elongation and P-TEFb activity, and how transcription elongation is coupled to specific chromatin modifications, including H3K4 methylation and H3K36 methylation in vivo. These studies should help us better understand the intricate links between transcription elongation, nucleosome methylation, and RNA processing and export in human cells. Another area of interest is the mechanisms that regulate Wnt and Notch signaling in human colon cancers. We recently showed that the Wnt co-activator, beta-catenin, interacts with factors required for H3K4 methylation of target genes, and that the APC tumor suppressor functions to down-regulate beta-catenin transcription at target genes. Recent studies indicate that Notch transcription is strongly regulated at the level of transcription elongation through P-TEFb and SKIP, and are studying how these factors are recruited and function in response to Notch signaling.
Search Pew Scholars
Institution Albert Einstein College of Medicine Amicrobe, Inc Arizona State University ARMGO Pharma, Inc. Asymmetrex LLC Baylor College of Medicine Beth Israel Deaconess Medical Center Biomedical Research Foundation, Academy of Athens Boston Children's Hospital Boston University Bowdoin College Brandeis University Brigham and Women's Hospital Brown University Buck Institute for Research on Aging California Institute of Technology California NanoSystems Institute Cardiovascular Consultants, Inc. Cardiovascular Research Institute Carnegie Institution for Science Case Western Reserve University Cedars-Sinai Medical Center Central South University Centre of Advanced European Studies and Research, Max-Planck Institutes Centro de Estudios Científicos Children's Hospital of Philadelphia Children's Hospital of Pittsburgh Cincinnati Children's Hospital Medical Center City of Hope National Medical Center Cold Spring Harbor Laboratory Colorado State University Columbia University Columbia University Mailman School of Public Health Columbia University Zuckerman Institute Cornell University Dana-Farber Cancer Institute Dartmouth College Department of biochemistry and molecular genetics Department of microbiology Duke University Ecole Polytechnique Fédérale de Lausanne (EPFL) Emory University Fox Chase Cancer Center Fred Hutchinson Cancer Research Center Friedrich-Alexander University of Erlangen-Nuremberg Geisel School of Medicine at Dartmouth Genentech, Inc. Georgia Institute of Technology Gladstone Institutes Harvard Medical School Harvard University Icahn School of Medicine at Mount Sinai Imperial College London Institut Jacques Monod Institute for Stem Cell Biology and Regenerative Medicine Iowa State University Janelia Farm Research Campus, HHMI Johannes Gutenberg University Mainz Johns Hopkins Bloomberg School of Public Health Johns Hopkins University Katholieke Universiteit Leuven Kavli Institute for Brain Science La Jolla Institute for Allergy and Immunology Lankenau Institute for Medical Research Lawrence Berkeley National Laboratory Lerner Research Institute, Cleveland Clinic Marine Biological Labratory Massachusetts General Hospital Massachusetts Institute of Technology Max Planck Institute for Brain Research Max Planck Institute for Molecular Genetics Medical College of Wisconsin MedPharm Consulting, Inc. Memorial Sloan-Kettering Cancer Center Merck and Co., Inc. Mortimer B. Zuckerman Mind Brain Behavior Institute National Cancer Institute National Heart, Lung, and Blood Institute National Institute of Genetics National Institute of Neurological Disorders and Stroke National Institutes of Health National Jewish Health National University of Singapore New York University New York University School of Medicine Newcastle University North Carolina State University Northern Arizona University Northwestern University Ohio State University Oklahoma Medical Research Foundation Oregon Health and Science University Pennsylvania State University Princeton University Proteogenomics Research Institute for Systems Medicine Purdue University Quinnipiac University Reactome Rensselaer Polytechnic Institute RIKEN Rockefeller University Rutgers University Rutgers University, Newark Saint Louis University Salk Institute for Biological Studies Sanford Burnham Prebys Medical Discovery Institute Scintillon Institute Scripps Research Institute Seattle Biomedical Research Institute Skirball Institute of Biomolecular Medicine St. Jude Children's Research Hospital Stanford University Stanford University School of Medicine State University of New York at Albany State University of New York at Buffalo Stony Brook University Stowers Institute for Medical Research Swiss Federal Institute of Technology Zurich Texas A & M University The Children's Hospital of Philadelphia The Commonwealth Medical College The Rockefeller University The Salk Institute for Biological Studies The Scripps Research Institute Thomas Jefferson University Tufts University School of Medicine U.S. Department of Energy UNITY Biotechnology Universidad de la Republica University at Buffalo, The State University of New York University Hospitals university of alberta University of Arizona University of Bristol University of British Columbia University of California, Berkeley University of California, Davis University of California, Irvine University of California, Los Angeles University of California, San Francisco University of California, Santa Cruz University of California, Merced University of California, Riverside University of California, San Diego University of Cambridge University of Chicago University of Cincinnati University of Colorado, Boulder University of Colorado, Denver University of Delaware University of Geneva University of Georgia university of houston University of Illinois at Chicago University of Iowa University of Kansas University of Kentucky University of Maryland, Baltimore University of Massachusetts, Amherst University of Massachusetts Medical School University of Medicine & Dentistry of New Jersey University of Miami University of Michigan University of Minnesota University of Missouri University of North Carolina at Chapel Hill University of Oregon University of Oslo University of Pennsylvania University of Pittsburgh University of Rochester University of Southern California University of Tennessee University of Texas at Austin University of Texas Health Science Center at Houston University of Texas Health Science Center at San Antonio University of Texas M.D. Anderson Cancer Center University of Texas Medical Branch at Galveston University of Texas Southwestern Medical Center University of Utah University of Vermont University of Virginia University of Würzburg University of Washington University of Wisconsin-Madison University of Wyoming U.S. Department of Health and Human Services Van Andel Institute Vanderbilt University Washington State University Washington University Washington University School of Medicine in St. Louis Weill Cornell Medical College Weinberg College of Arts and Sciences Western Michigan University Whitehead Institute for Biomedical Research Wistar Institute of Anatomy and Biology Yale University Yale University School of Medicine Zhejiang University Zuckerman Mind Brain and Behavior Institute Vanderbilt University Medical Center Cancer Research UK Cambridge Institute Universidad del Desarrollo
Award Year 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
State NY Alberta AZ CA CO CT DC DE FL GA Germany IA IL IL IN KS KY MA MA MD ME MI MN MO NC NH NJ NY OH OK OR PA RI TN TX United Kingdom UT VA VT WA WI WY
Innovation Fund Investigator
Scholar Keywords
HIV-1 promoter
Human colon cancers
P-TEFb
RNA Polymerase II elongation
1987 Search Pew Scholars
Robert E. Boswell, Ph.D.
Roger Brent, Ph.D.
Shing Y. Chiu, Ph.D.
Tucker Collins, M.D., Ph.D.
Sandra J.F. Degen, Ph.D.
Diane O. Etchison, Ph.D.
Lawrence C. Kuo, Ph.D.
Jeffrey L. Noebels, M.D., Ph.D.
Marilyn C. Pike, M.D., Ph.D.
Marilyn D. Resh, Ph.D.
Adrienne A. Rogalski-Wilk, Ph.D.
Philip M. Rosoff, M.D.
Christopher A. Ross, M.D., Ph.D.
Nilabh Shastri, Ph.D.
Michael P. Snyder, Ph.D.
Alison A. Weiss, Ph.D.
Morris F. White, Ph.D.
Alexander S. Whitehead, D. Phil.
Submit an update to this directory entry for Katherine A. Jones, Ph.D.