The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief
Hiroyuki Seki, Masanori Kashiwagi, Junichi Masuda, Nami Ohyama, Michihiro Kamata
麻酔学
Background: Dexamethasone is known to reduce the incidence of postoperative nausea and vomiting, associated with perioperative intrathecal, epidural, or intravenous morphine. However, the effect of dexamethasone on subcutaneous morphine is unclear. Therefore, we evaluated the antiemetic effect of intravenous dexamethasone during continuous subcutaneous infusion of morphine for post-operative pain relief. Methods: Twenty patients scheduled for spinal surgery under general anesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. The dexamethasone group (n = 10) received dexamethasone 8 mg and the saline group (n = 10) received the same amount of saline before the induction of anesthesia. Anesthesia was maintained with propofol and fentanyl. Postoperative pain was treated with continuous subcutaneous morphine via a patient-controlled analgesia device. Postoperatively patients were assessed during 48 hours for nausea and vomiting. Results: Nausea or vomiting ascribable to the subcutaneous morphine developed in 40% of the patients in each group (P:NS). Conclusions: Our results suggest that the single dose of dexamethasone (8 mg) does not reduce postoperative nausea and vomiting associated with continuous subcutaneous infusion of morphine after spinal surgery.
Japanese Journal of Anesthesiology
麻酔学および疼痛医療
「The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。
Subcutaneous Infusions Medicine & Life Sciences 100%
Antiemetics Medicine & Life Sciences 91%
Postoperative Pain Medicine & Life Sciences 76%
Morphine Medicine & Life Sciences 71%
Dexamethasone Medicine & Life Sciences 69%
Postoperative Nausea and Vomiting Medicine & Life Sciences 32%
Nausea Medicine & Life Sciences 22%
Vomiting Medicine & Life Sciences 21%
Seki, H., Kashiwagi, M., Masuda, J., Ohyama, N., & Kamata, M. (2005). The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief. Japanese Journal of Anesthesiology, 54(4), 381-386.
The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief. / Seki, Hiroyuki; Kashiwagi, Masanori; Masuda, Junichi その他.
In: Japanese Journal of Anesthesiology, Vol. 54, No. 4, 04.2005, p. 381-386.
Seki, H, Kashiwagi, M, Masuda, J, Ohyama, N & Kamata, M 2005, 'The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief', Japanese Journal of Anesthesiology, vol. 54, no. 4, pp. 381-386.
Seki H, Kashiwagi M, Masuda J, Ohyama N, Kamata M. The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief. Japanese Journal of Anesthesiology. 2005 4月;54(4):381-386.
Seki, Hiroyuki ; Kashiwagi, Masanori ; Masuda, Junichi その他. / The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief. In: Japanese Journal of Anesthesiology. 2005 ; Vol. 54, No. 4. pp. 381-386.
@article{5418e86f5ff4434986caf13a38b59e93,
title = "The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief",
abstract = "Background: Dexamethasone is known to reduce the incidence of postoperative nausea and vomiting, associated with perioperative intrathecal, epidural, or intravenous morphine. However, the effect of dexamethasone on subcutaneous morphine is unclear. Therefore, we evaluated the antiemetic effect of intravenous dexamethasone during continuous subcutaneous infusion of morphine for post-operative pain relief. Methods: Twenty patients scheduled for spinal surgery under general anesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. The dexamethasone group (n = 10) received dexamethasone 8 mg and the saline group (n = 10) received the same amount of saline before the induction of anesthesia. Anesthesia was maintained with propofol and fentanyl. Postoperative pain was treated with continuous subcutaneous morphine via a patient-controlled analgesia device. Postoperatively patients were assessed during 48 hours for nausea and vomiting. Results: Nausea or vomiting ascribable to the subcutaneous morphine developed in 40% of the patients in each group (P:NS). Conclusions: Our results suggest that the single dose of dexamethasone (8 mg) does not reduce postoperative nausea and vomiting associated with continuous subcutaneous infusion of morphine after spinal surgery.",
keywords = "Dexamethasone, Morphine, Nausea and vomiting",
author = "Hiroyuki Seki and Masanori Kashiwagi and Junichi Masuda and Nami Ohyama and Michihiro Kamata",
journal = "Japanese Journal of Anesthesiology",
publisher = "Kokuseido Publishing Co. Ltd",
T1 - The antiemetic effect of dexamethasone during continuous subcutaneous infusion of morphine for postoperative pain relief
AU - Seki, Hiroyuki
AU - Kashiwagi, Masanori
AU - Masuda, Junichi
AU - Ohyama, Nami
AU - Kamata, Michihiro
N2 - Background: Dexamethasone is known to reduce the incidence of postoperative nausea and vomiting, associated with perioperative intrathecal, epidural, or intravenous morphine. However, the effect of dexamethasone on subcutaneous morphine is unclear. Therefore, we evaluated the antiemetic effect of intravenous dexamethasone during continuous subcutaneous infusion of morphine for post-operative pain relief. Methods: Twenty patients scheduled for spinal surgery under general anesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. The dexamethasone group (n = 10) received dexamethasone 8 mg and the saline group (n = 10) received the same amount of saline before the induction of anesthesia. Anesthesia was maintained with propofol and fentanyl. Postoperative pain was treated with continuous subcutaneous morphine via a patient-controlled analgesia device. Postoperatively patients were assessed during 48 hours for nausea and vomiting. Results: Nausea or vomiting ascribable to the subcutaneous morphine developed in 40% of the patients in each group (P:NS). Conclusions: Our results suggest that the single dose of dexamethasone (8 mg) does not reduce postoperative nausea and vomiting associated with continuous subcutaneous infusion of morphine after spinal surgery.
AB - Background: Dexamethasone is known to reduce the incidence of postoperative nausea and vomiting, associated with perioperative intrathecal, epidural, or intravenous morphine. However, the effect of dexamethasone on subcutaneous morphine is unclear. Therefore, we evaluated the antiemetic effect of intravenous dexamethasone during continuous subcutaneous infusion of morphine for post-operative pain relief. Methods: Twenty patients scheduled for spinal surgery under general anesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. The dexamethasone group (n = 10) received dexamethasone 8 mg and the saline group (n = 10) received the same amount of saline before the induction of anesthesia. Anesthesia was maintained with propofol and fentanyl. Postoperative pain was treated with continuous subcutaneous morphine via a patient-controlled analgesia device. Postoperatively patients were assessed during 48 hours for nausea and vomiting. Results: Nausea or vomiting ascribable to the subcutaneous morphine developed in 40% of the patients in each group (P:NS). Conclusions: Our results suggest that the single dose of dexamethasone (8 mg) does not reduce postoperative nausea and vomiting associated with continuous subcutaneous infusion of morphine after spinal surgery.
KW - Dexamethasone
KW - Morphine
KW - Nausea and vomiting
JO - Japanese Journal of Anesthesiology
JF - Japanese Journal of Anesthesiology