Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings
John D. Kugler, William W. Pinsky, John P. Cheatham, Philip J. Hofschire, Paul K. Mooring, William H. Fleming
Pediatrics Cardiology
Cardiology, Children's Hospital
Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle. Using serial studies, the same sustained ventricular tachycardia was induced during therapeutic serum concentrations of phenytoin but not after propranolol. No patient had ventricular arrhythmia during a 24-hour electrocardiogram or during exercise. Although no patient had normal hemodynamic function, only 1 patient had right ventricular pressure greater than two-thirds systemic pressure. Each patient had undergone initial intracardiac repair at a relatively late age (3, 9, and 9 years).
The American Journal of Cardiology
Fingerprint Dive into the research topics of 'Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings'. Together they form a unique fingerprint.
Tetralogy of Fallot Medicine & Life Sciences
Ventricular Tachycardia Medicine & Life Sciences
Cardiac Arrhythmias Medicine & Life Sciences
Phenytoin Medicine & Life Sciences
Septum of Brain Medicine & Life Sciences
Patient Rights Medicine & Life Sciences
Kugler, J. D., Pinsky, W. W., Cheatham, J. P., Hofschire, P. J., Mooring, P. K., & Fleming, W. H. (1983). Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings. The American Journal of Cardiology, 51(7), 1137-1143. https://doi.org/10.1016/0002-9149(83)90359-4
Sustained ventricular tachycardia after repair of tetralogy of Fallot : New electrophysiologic findings. / Kugler, John D.; Pinsky, William W.; Cheatham, John P.; Hofschire, Philip J.; Mooring, Paul K.; Fleming, William H.
In: The American Journal of Cardiology, Vol. 51, No. 7, 04.1983, p. 1137-1143.
Kugler, JD, Pinsky, WW, Cheatham, JP, Hofschire, PJ, Mooring, PK & Fleming, WH 1983, 'Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings', The American Journal of Cardiology, vol. 51, no. 7, pp. 1137-1143. https://doi.org/10.1016/0002-9149(83)90359-4
Kugler JD, Pinsky WW, Cheatham JP, Hofschire PJ, Mooring PK, Fleming WH. Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings. The American Journal of Cardiology. 1983 Apr;51(7):1137-1143. https://doi.org/10.1016/0002-9149(83)90359-4
Kugler, John D. ; Pinsky, William W. ; Cheatham, John P. ; Hofschire, Philip J. ; Mooring, Paul K. ; Fleming, William H. / Sustained ventricular tachycardia after repair of tetralogy of Fallot : New electrophysiologic findings. In: The American Journal of Cardiology. 1983 ; Vol. 51, No. 7. pp. 1137-1143.
@article{95f530f88fd2456e9a8eaebaace1cbda,
title = "Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings",
abstract = "Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle. Using serial studies, the same sustained ventricular tachycardia was induced during therapeutic serum concentrations of phenytoin but not after propranolol. No patient had ventricular arrhythmia during a 24-hour electrocardiogram or during exercise. Although no patient had normal hemodynamic function, only 1 patient had right ventricular pressure greater than two-thirds systemic pressure. Each patient had undergone initial intracardiac repair at a relatively late age (3, 9, and 9 years).",
author = "Kugler, {John D.} and Pinsky, {William W.} and Cheatham, {John P.} and Hofschire, {Philip J.} and Mooring, {Paul K.} and Fleming, {William H.}",
journal = "American Journal of Cardiology",
T1 - Sustained ventricular tachycardia after repair of tetralogy of Fallot
T2 - New electrophysiologic findings
AU - Kugler, John D.
AU - Pinsky, William W.
AU - Cheatham, John P.
AU - Hofschire, Philip J.
AU - Mooring, Paul K.
AU - Fleming, William H.
N2 - Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle. Using serial studies, the same sustained ventricular tachycardia was induced during therapeutic serum concentrations of phenytoin but not after propranolol. No patient had ventricular arrhythmia during a 24-hour electrocardiogram or during exercise. Although no patient had normal hemodynamic function, only 1 patient had right ventricular pressure greater than two-thirds systemic pressure. Each patient had undergone initial intracardiac repair at a relatively late age (3, 9, and 9 years).
AB - Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle. Using serial studies, the same sustained ventricular tachycardia was induced during therapeutic serum concentrations of phenytoin but not after propranolol. No patient had ventricular arrhythmia during a 24-hour electrocardiogram or during exercise. Although no patient had normal hemodynamic function, only 1 patient had right ventricular pressure greater than two-thirds systemic pressure. Each patient had undergone initial intracardiac repair at a relatively late age (3, 9, and 9 years).
JO - American Journal of Cardiology
JF - American Journal of Cardiology