Molecular & Computational biology
What can you do with two omes that you can't do with one?
by American Society for Biochemistry and Molecular Biology
As analytical tools improve, researchers are combining proteomic, genomic, transcriptomic and other omic data to better understand biological systems. The current issue of Molecular and Cellular Proteomics focuses on multiomics tools and research results. Credit: Molecular & Cellular Proteomics
What can you learn from two omes that you can't tell from one? You might determine how different bacterial strains in a water sample contribute specific functions to its overall microbiome. You might find that duplication of a section of a chromosome in cancer cells has wide-reaching effects on important proteins—or that it has a smaller effect than expected. First, though, you need to find a way to wrangle gigabytes of data saved in numerous, perhaps incompatible formats.
As high-throughput analytical tools improve, allowing researchers to collect more and more data, the challenge becomes how to interpret it all. When transcriptomic, genomic, metabolomic and proteomic analyses are layered together, parsing out a signal can be a monumental task. The field needs new analytical strategies, and new user-friendly software, to condense RNA counts, genotypes, and mass spectra showing proteins, post-translational modifications, complex carbohydrates and metabolites into coherent, interpretable results.
Researchers surfing this multiomics wave report a plethora of new tools and approaches this month in a special issue of the journal Molecular & Cellular Proteomics devoted to integrating multiple omics. The issue, edited by Bernhard Kuster of the Technical University of Munich and Bing Zhang of the Baylor College of Medicine, includes sixteen articles that explore ways to combine data from two or more omes at a time.
Artificial intelligence boosts proteome research
More information: Weiping Ma et al, Integrative proteo-genomic analysis to construct CNA-protein regulatory map in breast and ovarian tumors, Molecular & Cellular Proteomics (2019). DOI: 10.1074/mcp.RA118.001229
Journal information: Molecular and Cellular Proteomics , Molecular & Cellular Proteomics
Provided by American Society for Biochemistry and Molecular Biology
Citation: What can you do with two omes that you can't do with one? (2019, August 6) retrieved 22 January 2020 from https://phys.org/news/2019-08-omes.html
Analyzing colon cancer proteins and genes uncovers new potential treatments
Milestone for the analysis of human proteomes
New open-source software for analyzing intact proteins
The new age of proteomics: An integrative vision of the cellular world
Integrated, multi-'omic' studies of asthma could lead to precision treatment
Method triggers selective degradation of proteins for analysis
Surveying all the proteins on a neuron's surface
Plant organ growth is not so different from animals
'Living fossil' may upend basic tenet of evolutionary theory