Allotransplantation de tissus composites et chirurgie plastique: Les premières applications cliniques
: Reconstructive surgery using composite tissue allografts: Perspectives from the first clinical cases
F. Petit, L. Lantieri, J. C. Guimberteau, D. Hannouche, W. P.Andrew Lee
Tissue allotransplantation is defined by the transfer of tissues harvested from a cadaveric donor (in a brain dead condition) and revascularized to a recipient subject. This is based on the mastery of microsurgical techniques and on the induction of a therapeutic immunosuppression for the recipient. The first allografts (flexor tendon systems, knees and femoral diaphysis, hands, nerves, larynx) opened the field of composite tissue allotransplantation (C.T.A.) in reconstructive surgery. Immunosuppressive agents are now efficient enough to prevent the rejection of the allografts. The first patients operated on did not suffer from major or irreversible complications, but some potential side-effects of the immunosuppression remain an obstacle to the development of allografts in reconstructive surgery. The early functional results of the allografts are encouraging but their long term evolution remains uncertain. Some immunological (the chronic rejection) or psychological (the refusal of the graft and of its constraints) phenomenon might curtail the functional, aesthetic and psychological result. Currently considered as an extreme solution to exceptional indications, C.T.A. represents a tremendous hope for the future of reconstructive surgery.
Reconstructive surgery using composite tissue allografts: Perspectives from the first clinical cases
Annales de Chirurgie Plastique Esthetique
Allotransplantation
Hand allograft
Dive into the research topics of 'Reconstructive surgery using composite tissue allografts: Perspectives from the first clinical cases'. Together they form a unique fingerprint.
Composite Tissue Allografts Medicine & Life Sciences 100%
Reconstructive Surgical Procedures Medicine & Life Sciences 64%
Allografts Medicine & Life Sciences 50%
Vascularized Composite Allotransplantation Medicine & Life Sciences 47%
Psychology Rejection Medicine & Life Sciences 33%
Immunosuppression Medicine & Life Sciences 26%
Diaphyses Medicine & Life Sciences 18%
Brain Death Medicine & Life Sciences 17%
Petit, F., Lantieri, L., Guimberteau, J. C., Hannouche, D., & Lee, W. P. A. (2002). Allotransplantation de tissus composites et chirurgie plastique: Les premières applications cliniques. Annales de Chirurgie Plastique Esthetique, 47(3), 222-231. https://doi.org/10.1016/S0294-1260(02)00114-0
Allotransplantation de tissus composites et chirurgie plastique : Les premières applications cliniques. / Petit, F.; Lantieri, L.; Guimberteau, J. C.; Hannouche, D.; Lee, W. P.Andrew.
In: Annales de Chirurgie Plastique Esthetique, Vol. 47, No. 3, 2002, p. 222-231.
Petit, F, Lantieri, L, Guimberteau, JC, Hannouche, D & Lee, WPA 2002, 'Allotransplantation de tissus composites et chirurgie plastique: Les premières applications cliniques', Annales de Chirurgie Plastique Esthetique, vol. 47, no. 3, pp. 222-231. https://doi.org/10.1016/S0294-1260(02)00114-0
Petit F, Lantieri L, Guimberteau JC, Hannouche D, Lee WPA. Allotransplantation de tissus composites et chirurgie plastique: Les premières applications cliniques. Annales de Chirurgie Plastique Esthetique. 2002;47(3):222-231. https://doi.org/10.1016/S0294-1260(02)00114-0
Petit, F. ; Lantieri, L. ; Guimberteau, J. C. ; Hannouche, D. ; Lee, W. P.Andrew. / Allotransplantation de tissus composites et chirurgie plastique : Les premières applications cliniques. In: Annales de Chirurgie Plastique Esthetique. 2002 ; Vol. 47, No. 3. pp. 222-231.
@article{544353a11e77491e9f8a2db3205eb99f,
title = "Allotransplantation de tissus composites et chirurgie plastique: Les premi{\`e}res applications cliniques",
abstract = "Tissue allotransplantation is defined by the transfer of tissues harvested from a cadaveric donor (in a brain dead condition) and revascularized to a recipient subject. This is based on the mastery of microsurgical techniques and on the induction of a therapeutic immunosuppression for the recipient. The first allografts (flexor tendon systems, knees and femoral diaphysis, hands, nerves, larynx) opened the field of composite tissue allotransplantation (C.T.A.) in reconstructive surgery. Immunosuppressive agents are now efficient enough to prevent the rejection of the allografts. The first patients operated on did not suffer from major or irreversible complications, but some potential side-effects of the immunosuppression remain an obstacle to the development of allografts in reconstructive surgery. The early functional results of the allografts are encouraging but their long term evolution remains uncertain. Some immunological (the chronic rejection) or psychological (the refusal of the graft and of its constraints) phenomenon might curtail the functional, aesthetic and psychological result. Currently considered as an extreme solution to exceptional indications, C.T.A. represents a tremendous hope for the future of reconstructive surgery.",
keywords = "Allotransplantation, Hand allograft, Immunosuppression, Reconstructive surgery",
author = "F. Petit and L. Lantieri and Guimberteau, {J. C.} and D. Hannouche and Lee, {W. P.Andrew}",
language = "French",
journal = "Annales de Chirurgie Plastique et Esthetique",
publisher = "Elsevier Masson",
T1 - Allotransplantation de tissus composites et chirurgie plastique
T2 - Les premières applications cliniques
AU - Petit, F.
AU - Lantieri, L.
AU - Guimberteau, J. C.
AU - Hannouche, D.
AU - Lee, W. P.Andrew
N2 - Tissue allotransplantation is defined by the transfer of tissues harvested from a cadaveric donor (in a brain dead condition) and revascularized to a recipient subject. This is based on the mastery of microsurgical techniques and on the induction of a therapeutic immunosuppression for the recipient. The first allografts (flexor tendon systems, knees and femoral diaphysis, hands, nerves, larynx) opened the field of composite tissue allotransplantation (C.T.A.) in reconstructive surgery. Immunosuppressive agents are now efficient enough to prevent the rejection of the allografts. The first patients operated on did not suffer from major or irreversible complications, but some potential side-effects of the immunosuppression remain an obstacle to the development of allografts in reconstructive surgery. The early functional results of the allografts are encouraging but their long term evolution remains uncertain. Some immunological (the chronic rejection) or psychological (the refusal of the graft and of its constraints) phenomenon might curtail the functional, aesthetic and psychological result. Currently considered as an extreme solution to exceptional indications, C.T.A. represents a tremendous hope for the future of reconstructive surgery.
AB - Tissue allotransplantation is defined by the transfer of tissues harvested from a cadaveric donor (in a brain dead condition) and revascularized to a recipient subject. This is based on the mastery of microsurgical techniques and on the induction of a therapeutic immunosuppression for the recipient. The first allografts (flexor tendon systems, knees and femoral diaphysis, hands, nerves, larynx) opened the field of composite tissue allotransplantation (C.T.A.) in reconstructive surgery. Immunosuppressive agents are now efficient enough to prevent the rejection of the allografts. The first patients operated on did not suffer from major or irreversible complications, but some potential side-effects of the immunosuppression remain an obstacle to the development of allografts in reconstructive surgery. The early functional results of the allografts are encouraging but their long term evolution remains uncertain. Some immunological (the chronic rejection) or psychological (the refusal of the graft and of its constraints) phenomenon might curtail the functional, aesthetic and psychological result. Currently considered as an extreme solution to exceptional indications, C.T.A. represents a tremendous hope for the future of reconstructive surgery.
KW - Allotransplantation
KW - Hand allograft
KW - Immunosuppression
KW - Reconstructive surgery
JO - Annales de Chirurgie Plastique et Esthetique
JF - Annales de Chirurgie Plastique et Esthetique