tRNA fragments are involved in poststroke immune reactions
Sebastian Lobentanzer of Goethe University, Frankfurt, has been studying small RNA dynamics in various contexts using bioinformatic methods. Recently, small RNAs have become more and more interesting for researchers, primarily because of their extensive regulatory functions. To examine these functions in stroke, Lobentanzer joined Katarzyna Winek of Hebrew University, Jerusalem, to study microRNAs and tRNA fragments in blood samples from ischemic stroke patients collected at Charité, Berlin. "tRNA fragments, which until now were only thought to be debris of the amino acid-transporting tRNAs, have recently been shown to possess biological functions; naturally, we were very interested in that," explains the pharmacologist.
The project was initiated and led by Hermona Soreq (Hebrew University, Jerusalem, Israel) and Andreas Meisel (Charité, Berlin), who jointly study the contributions of small RNA regulators of cholinergic signaling in blood cells of stroke patients, funded by the Einstein Foundation. Katarzyna Winek from The Edmond and Lily Safra Center of Brain Science at The Hebrew University collaborated with Sebastian Lobentanzer at the Institute for Pharmacology and Clinical Pharmacy (AK Jochen Klein) at Goethe University Frankfurt, Germany.
This collaborative effort was able to show, for the first time, the involvement of monocytic tRNA fragments in the poststroke immune response. "Simply put, there may be a 'changing of the guards,' in which tRNA fragments replace microRNAs in monocytes," explains Lobentanzer. "Bioinformatic network analyses show that these two small RNA species have vastly different functional roles in the immune response, and thus may work in synergy in the regulation of homeostasis." In the long run, the researchers want to find therapeutics to modify these processes. Indeed, if the immune status of each patient after a stroke could be individually determined, many complications could be avoided.
Related Immune Response Articles from Brightsurf:
Boosting chickens' own immune response could curb disease
Broiler chicken producers the world over are all too familiar with coccidiosis, a parasite-borne intestinal disease that stalls growth and winnows flocks.
Cells sacrifice themselves to boost immune response to viruses
Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection.
Children's immune response more effective against COVID-19
Children and adults exhibit distinct immune system responses to infection by the virus that causes COVID-19, a finding that helps explain why COVID-19 outcomes tend to be much worse in adults, researchers from Yale and Albert Einstein College of Medicine report Sept.
Which immune response could cause a vaccine against COVID-19?
Immune reactions caused by vaccination can help protect the organism, or sometimes may aggravate the condition.
Obesity may alter immune system response to COVID-19
Obesity may cause a hyperactive immune system response to COVID-19 infection that makes it difficult to fight off the virus, according to a new manuscript published in the Endocrine Society's journal, Endocrinology.
Immune response to Sars-Cov-2 following organ transplantation
Even patients with suppressed immune systems can achieve a strong immune response to Sars-Cov-2.
'Relaxed' T cells critical to immune response
Rice University researchers model the role of relaxation time as T cells bind to invaders or imposters, and how their ability to differentiate between the two triggers the body's immune system.
A novel mechanism that triggers a cellular immune response
Researchers at Baylor College of Medicine present comprehensive evidence that supports a novel trigger for a cell-mediated response and propose a mechanism for its action.
Platelets exacerbate immune response
Platelets not only play a key role in blood clotting, but can also significantly intensify inflammatory processes.
How to boost immune response to vaccines in older people
Identifying interventions that improve vaccine efficacy in older persons is vital to deliver healthy ageing for an ageing population.
Read More: Immune Response News and Immune Response Current Events