The ketogenic diet: Scientific principles underlying its use
Kristopher J. Bough, Carl E. Stafstrom
The ketogenic diet (KD) is a high-fat, low-carbohydrate, low-protein diet that was initially formulated in the early 1920s as a treatment for intractable epilepsy (Wilder, 1921). Physicians in the 1920s and 1930s were well aware of the effectiveness of the diet; at that time, phenobarbital was the only other epilepsy treatment in widespread use. With the discovery of phenytoin in 1935, and other anticonvulsant medications over subsequent decades, the KD was used much less frequently; however, over the past 15 years, the KD has re-emerged as a viable alternative to standard anticonvulsants in the treatment of refractory epilepsy, especially in children (Freeman et al., 2007b; Kossoff et al., 2009). The history of the KD, including its origin and the reasons for the recent resurgence in its use, is reviewed elsewhere in detail (Freeman et al., 2007a, b; Swink et al., 1997; Wheless, 2004).
Mechanisms, Models, and Translational Perspectives
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Ketogenic Diet Medicine & Life Sciences 100%
Drug Resistant Epilepsy Medicine & Life Sciences 40%
Anticonvulsants Medicine & Life Sciences 33%
Protein-Restricted Diet Medicine & Life Sciences 23%
Phenytoin Medicine & Life Sciences 20%
Phenobarbital Medicine & Life Sciences 19%
Carbohydrates Medicine & Life Sciences 15%
Epilepsy Medicine & Life Sciences 15%
Bough, K. J., & Stafstrom, C. E. (2010). The ketogenic diet: Scientific principles underlying its use. In Epilepsy: Mechanisms, Models, and Translational Perspectives (pp. 417-439). CRC Press. https://doi.org/10.1201/9781420085594
The ketogenic diet : Scientific principles underlying its use. / Bough, Kristopher J.; Stafstrom, Carl E.
Epilepsy: Mechanisms, Models, and Translational Perspectives. CRC Press, 2010. p. 417-439.
Bough, KJ & Stafstrom, CE 2010, The ketogenic diet: Scientific principles underlying its use. in Epilepsy: Mechanisms, Models, and Translational Perspectives. CRC Press, pp. 417-439. https://doi.org/10.1201/9781420085594
Bough KJ, Stafstrom CE. The ketogenic diet: Scientific principles underlying its use. In Epilepsy: Mechanisms, Models, and Translational Perspectives. CRC Press. 2010. p. 417-439 https://doi.org/10.1201/9781420085594
Bough, Kristopher J. ; Stafstrom, Carl E. / The ketogenic diet : Scientific principles underlying its use. Epilepsy: Mechanisms, Models, and Translational Perspectives. CRC Press, 2010. pp. 417-439
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title = "The ketogenic diet: Scientific principles underlying its use",
abstract = "The ketogenic diet (KD) is a high-fat, low-carbohydrate, low-protein diet that was initially formulated in the early 1920s as a treatment for intractable epilepsy (Wilder, 1921). Physicians in the 1920s and 1930s were well aware of the effectiveness of the diet; at that time, phenobarbital was the only other epilepsy treatment in widespread use. With the discovery of phenytoin in 1935, and other anticonvulsant medications over subsequent decades, the KD was used much less frequently; however, over the past 15 years, the KD has re-emerged as a viable alternative to standard anticonvulsants in the treatment of refractory epilepsy, especially in children (Freeman et al., 2007b; Kossoff et al., 2009). The history of the KD, including its origin and the reasons for the recent resurgence in its use, is reviewed elsewhere in detail (Freeman et al., 2007a, b; Swink et al., 1997; Wheless, 2004).",
author = "Bough, {Kristopher J.} and Stafstrom, {Carl E.}",
booktitle = "Epilepsy",
publisher = "CRC Press",
T1 - The ketogenic diet
T2 - Scientific principles underlying its use
AU - Bough, Kristopher J.
AU - Stafstrom, Carl E.
N2 - The ketogenic diet (KD) is a high-fat, low-carbohydrate, low-protein diet that was initially formulated in the early 1920s as a treatment for intractable epilepsy (Wilder, 1921). Physicians in the 1920s and 1930s were well aware of the effectiveness of the diet; at that time, phenobarbital was the only other epilepsy treatment in widespread use. With the discovery of phenytoin in 1935, and other anticonvulsant medications over subsequent decades, the KD was used much less frequently; however, over the past 15 years, the KD has re-emerged as a viable alternative to standard anticonvulsants in the treatment of refractory epilepsy, especially in children (Freeman et al., 2007b; Kossoff et al., 2009). The history of the KD, including its origin and the reasons for the recent resurgence in its use, is reviewed elsewhere in detail (Freeman et al., 2007a, b; Swink et al., 1997; Wheless, 2004).
AB - The ketogenic diet (KD) is a high-fat, low-carbohydrate, low-protein diet that was initially formulated in the early 1920s as a treatment for intractable epilepsy (Wilder, 1921). Physicians in the 1920s and 1930s were well aware of the effectiveness of the diet; at that time, phenobarbital was the only other epilepsy treatment in widespread use. With the discovery of phenytoin in 1935, and other anticonvulsant medications over subsequent decades, the KD was used much less frequently; however, over the past 15 years, the KD has re-emerged as a viable alternative to standard anticonvulsants in the treatment of refractory epilepsy, especially in children (Freeman et al., 2007b; Kossoff et al., 2009). The history of the KD, including its origin and the reasons for the recent resurgence in its use, is reviewed elsewhere in detail (Freeman et al., 2007a, b; Swink et al., 1997; Wheless, 2004).
BT - Epilepsy
PB - CRC Press