Inwardly Rectifying Potassium Channels
H. T. Kurata, C. G. Nichols
Department of Cell Biology & Physiology
DBBS - Neurosciences
DBBS - Biochemistry, Biophysics, and Structural Biology
Inwardly rectifying potassium (Kir) channels exhibit little or no intrinsic voltage dependence, but their activity can be dramatically influenced by a number of ligands and naturally occurring channel blockers. Kir channels play a critical role in a number of physiological processes and genetic diseases, and recent structural descriptions of a bacterial Kir homolog and isolated domains of eukaryotic Kirs have contributed to our detailed understanding of the function and regulation of these channels. This article describes the critical structural features of Kir channels and the mechanisms underlying channel regulation by polyamine blockers and various ligands, including nucleotides, G βγ subunits, and phospholipids.
Encyclopedia of Neuroscience
Elsevier Ltd
https://doi.org/10.1016/B978-008045046-9.01635-1
GIRK
Inward rectifier
KATP
PIP2
Polyamine
Potassium channel
Spermine
10.1016/B978-008045046-9.01635-1
Dive into the research topics of 'Inwardly Rectifying Potassium Channels'. Together they form a unique fingerprint.
Inwardly Rectifying Potassium Channels Medicine & Life Sciences 100%
Polyamines Medicine & Life Sciences 42%
Physiological Phenomena Medicine & Life Sciences 37%
Phospholipids Medicine & Life Sciences 32%
Nucleotides Medicine & Life Sciences 29%
Kurata, H. T., & Nichols, C. G. (2009). Inwardly Rectifying Potassium Channels. In Encyclopedia of Neuroscience (pp. 213-219). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.01635-1
Kurata, H. T. ; Nichols, C. G. / Inwardly Rectifying Potassium Channels. Encyclopedia of Neuroscience. Elsevier Ltd, 2009. pp. 213-219
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title = "Inwardly Rectifying Potassium Channels",
abstract = "Inwardly rectifying potassium (Kir) channels exhibit little or no intrinsic voltage dependence, but their activity can be dramatically influenced by a number of ligands and naturally occurring channel blockers. Kir channels play a critical role in a number of physiological processes and genetic diseases, and recent structural descriptions of a bacterial Kir homolog and isolated domains of eukaryotic Kirs have contributed to our detailed understanding of the function and regulation of these channels. This article describes the critical structural features of Kir channels and the mechanisms underlying channel regulation by polyamine blockers and various ligands, including nucleotides, G βγ subunits, and phospholipids.",
keywords = "GIRK, Inward rectifier, KATP, PIP2, Polyamine, Potassium channel, Spermidine, Spermine",
author = "Kurata, {H. T.} and Nichols, {C. G.}",
doi = "10.1016/B978-008045046-9.01635-1",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",
Kurata, HT & Nichols, CG 2009, Inwardly Rectifying Potassium Channels. in Encyclopedia of Neuroscience. Elsevier Ltd, pp. 213-219. https://doi.org/10.1016/B978-008045046-9.01635-1
Inwardly Rectifying Potassium Channels. / Kurata, H. T.; Nichols, C. G.
Encyclopedia of Neuroscience. Elsevier Ltd, 2009. p. 213-219.
T1 - Inwardly Rectifying Potassium Channels
AU - Kurata, H. T.
AU - Nichols, C. G.
N2 - Inwardly rectifying potassium (Kir) channels exhibit little or no intrinsic voltage dependence, but their activity can be dramatically influenced by a number of ligands and naturally occurring channel blockers. Kir channels play a critical role in a number of physiological processes and genetic diseases, and recent structural descriptions of a bacterial Kir homolog and isolated domains of eukaryotic Kirs have contributed to our detailed understanding of the function and regulation of these channels. This article describes the critical structural features of Kir channels and the mechanisms underlying channel regulation by polyamine blockers and various ligands, including nucleotides, G βγ subunits, and phospholipids.
AB - Inwardly rectifying potassium (Kir) channels exhibit little or no intrinsic voltage dependence, but their activity can be dramatically influenced by a number of ligands and naturally occurring channel blockers. Kir channels play a critical role in a number of physiological processes and genetic diseases, and recent structural descriptions of a bacterial Kir homolog and isolated domains of eukaryotic Kirs have contributed to our detailed understanding of the function and regulation of these channels. This article describes the critical structural features of Kir channels and the mechanisms underlying channel regulation by polyamine blockers and various ligands, including nucleotides, G βγ subunits, and phospholipids.
KW - GIRK
KW - Inward rectifier
KW - KATP
KW - PIP2
KW - Polyamine
KW - Potassium channel
KW - Spermidine
KW - Spermine
U2 - 10.1016/B978-008045046-9.01635-1
DO - 10.1016/B978-008045046-9.01635-1
BT - Encyclopedia of Neuroscience
PB - Elsevier Ltd
Kurata HT, Nichols CG. Inwardly Rectifying Potassium Channels. In Encyclopedia of Neuroscience. Elsevier Ltd. 2009. p. 213-219 doi: 10.1016/B978-008045046-9.01635-1