Dr. (Prof) Col OP Garg, VSM
is a senior Rheumatologist with 30 years of robust experience in treating 100 types of arthritis and other joint pain diseases. He is presently the Director of 'Rheumed Clinic - The Centre for Arthritis Control' in Dwarka, Delhi & senior consultant Rheumatologist, Artemis Hospital, Dwarka. Formerly, he has been Senior Rheumatologist at Army Hospital R&R, Delhi & HoD, Rheumatology at BL Kapur Hospital, Delhi. He has also been awarded for his excellent service by the President of India. In this blog, he talks about various conditions related to joint pains like Osteoarthritis, Rheumatoid Arthritis, Ankolysing Spondylitis, Juvenile Rheumatoid Arthritis etc.
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Local placement of Estrogen & Androgen may prove beneficial in Advanced Osteoarthritis
by Dr. OP Garg on Aug 2, 2016 • 7:35 AM2 Comments
The April issue of Arthritis & Rheumatism brings with it good news, which I would like to share with all the readers. I'm excited to know that even in the case of a degenerative arthritis called Osteoarthritis, lot of new researches are happening and the latest evidence has shown the presence of CPC ie, chondrogenic progenitor cells even in the late stages of Osteoarthritis and cartilage tissues had receptor for estrogen and androgen. Local placement of these hormones may prove beneficial in future studies. I'm eagerly awaiting results. If you want to read the full article please see below,
TUESDAY, March 30 (HealthDay News) —
Hormone replacement therapy directed to joint fluid may help regenerate damaged cartilage tissue in people with advanced osteoarthritis, according to German researchers.
Their study aimed to examine the regenerative potential of a type of cell — chondrogenic progenitor cells, or CPCS — that is present in the late stages of osteoarthritis. The researchers speculated that these cells might be influenced by the sex hormones estrogen, which has been shown to affect bone metabolism, and testosterone.
They analyzed tissue samples from 372 men and women with arthritis who'd had a total knee replacement. Most were in their early 70s.
In the joint fluid of the participants, they found 17 beta-estradiol, a form of estrogen, which they said increases calcium deposition in both sexes. And, in the osteoarthritic tissue, they found CPCs positive for estrogen receptors and androgen receptors.
The researchers, also found that unique CPCs were present in the cartilage of people with late-stage osteoarthritis (OA).
"We were able to isolate CPCs in 95.48% of female patients and 96.97% of male patients, making these cells a good target for future therapeutic intervention for a very large number of OA patients," Dr. Nicolai Miosge, from August University in Goettingen, said in a news release from Wiley-Blackwell, which publishes Arthritis & Rheumatism.
The findings are reported in the journal's April issue.
"Hormone replacement therapy in joint fluid may help mitigate the effects of OA," Miosge concluded, adding that further investigation was needed.
— Robert Preidt
Copyright © 2010 HealthDay. All rights reserved.
SOURCE: Wiley-Blackwell, news release, March 30, 2010
Link-http://www.medicinenet.com/script/main/art.asp?articlekey=114856
Tags: Arthritis, Delhi, hormones, India, OA, Osteoarthritis, Rheumatologist, Therapy
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Thank you Sheena for such nice words.
Posted by Dr. OP Garg on Sunday, 26 July 2015
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