Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome
Kazuyoshi Gotoh, Yoshihiko Sakaguchi, Haru Kato, Hayato Osaki, Yasutaka Jodai, Mitsutaka Wakuda, Akira Také, Shunji Hayashi, Eri Morita, Takehiko Sugie, Yoichiro Ito, Naoki Ohmiya
Recurrent Clostridioides difficile infection (rCDI) is a frustrating condition that may affect a person's quality of life for months. Microbiome-based therapy such as fecal microbiota transplantation (FMT) has been effective for the treatment of rCDI by correcting the imbalance of the gut microbiota. Appropriate antibiotic treatment is recommended for at least two recurrences before offering FMT. Here, we report the case of a 92-year-old woman who experienced five recurrences of Clostridioides difficile infection (CDI) (six episodes in total) complicated by dementia and delirium, both of which were dramatically improved by FMT, which was associated with alterations in fecal microbiota and the metabolome. Analyses of whole microbial communities and metabolomic analyses were performed on stool specimens collected from the patient on the first episode, the third episode, the day of FMT (before FMT), and 2, 8, and 23 weeks after the FMT and from the donor. The patient had various fecal dysbioses on the first and third episodes and on the day of FMT. Two weeks after FMT, diversity of the gut bacteriome as well as the virome increased dramatically and was reflected in a positive clinical outcome for this patient. Metabolomic analysis revealed that short-chain fatty acids, which have been reported to be associated with improved memory function, were increased after FMT.
https://doi.org/10.1016/j.anaerobe.2021.102502
10.1016/j.anaerobe.2021.102502
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Fecal Microbiota Transplantation Medicine & Life Sciences 100%
Delirium Medicine & Life Sciences 79%
Metabolome Medicine & Life Sciences 78%
Microbiota Medicine & Life Sciences 68%
Metabolomics Medicine & Life Sciences 16%
Volatile Fatty Acids Medicine & Life Sciences 9%
Gotoh, K., Sakaguchi, Y., Kato, H., Osaki, H., Jodai, Y., Wakuda, M., Také, A., Hayashi, S., Morita, E., Sugie, T., Ito, Y., & Ohmiya, N. (2022). Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome. Anaerobe, 73, [102502]. https://doi.org/10.1016/j.anaerobe.2021.102502
Gotoh, Kazuyoshi ; Sakaguchi, Yoshihiko ; Kato, Haru et al. / Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome. In: Anaerobe. 2022 ; Vol. 73.
@article{255a35fe82c8412c8f585333a03f9ea6,
title = "Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome",
abstract = "Recurrent Clostridioides difficile infection (rCDI) is a frustrating condition that may affect a person's quality of life for months. Microbiome-based therapy such as fecal microbiota transplantation (FMT) has been effective for the treatment of rCDI by correcting the imbalance of the gut microbiota. Appropriate antibiotic treatment is recommended for at least two recurrences before offering FMT. Here, we report the case of a 92-year-old woman who experienced five recurrences of Clostridioides difficile infection (CDI) (six episodes in total) complicated by dementia and delirium, both of which were dramatically improved by FMT, which was associated with alterations in fecal microbiota and the metabolome. Analyses of whole microbial communities and metabolomic analyses were performed on stool specimens collected from the patient on the first episode, the third episode, the day of FMT (before FMT), and 2, 8, and 23 weeks after the FMT and from the donor. The patient had various fecal dysbioses on the first and third episodes and on the day of FMT. Two weeks after FMT, diversity of the gut bacteriome as well as the virome increased dramatically and was reflected in a positive clinical outcome for this patient. Metabolomic analysis revealed that short-chain fatty acids, which have been reported to be associated with improved memory function, were increased after FMT.",
author = "Kazuyoshi Gotoh and Yoshihiko Sakaguchi and Haru Kato and Hayato Osaki and Yasutaka Jodai and Mitsutaka Wakuda and Akira Tak{\'e} and Shunji Hayashi and Eri Morita and Takehiko Sugie and Yoichiro Ito and Naoki Ohmiya",
note = "Funding Information: This work was supported by JSPS KAKENHI Grant Number JP19K07560 , Kurozumi Medical Foundation , Yakult Bio-Science Foundation , The Research Foundation for Pharmaceutical Sciences , and by research grants from the Kitasato University, School of Medicine , Parents{\textquoteright} Association Grant of Kitasato University, School of Medicine , and the Japan Agency for Medical Research and Development ( JP 20fk0108139 ). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
doi = "10.1016/j.anaerobe.2021.102502",
journal = "Anaerobe",
Gotoh, K, Sakaguchi, Y, Kato, H, Osaki, H, Jodai, Y, Wakuda, M, Také, A, Hayashi, S, Morita, E, Sugie, T, Ito, Y & Ohmiya, N 2022, 'Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome', Anaerobe, vol. 73, 102502. https://doi.org/10.1016/j.anaerobe.2021.102502
Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome. / Gotoh, Kazuyoshi; Sakaguchi, Yoshihiko; Kato, Haru et al.
In: Anaerobe, Vol. 73, 102502, 02.2022.
T1 - Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome
AU - Gotoh, Kazuyoshi
AU - Sakaguchi, Yoshihiko
AU - Kato, Haru
AU - Osaki, Hayato
AU - Jodai, Yasutaka
AU - Wakuda, Mitsutaka
AU - Také, Akira
AU - Hayashi, Shunji
AU - Morita, Eri
AU - Sugie, Takehiko
AU - Ito, Yoichiro
AU - Ohmiya, Naoki
N1 - Funding Information: This work was supported by JSPS KAKENHI Grant Number JP19K07560 , Kurozumi Medical Foundation , Yakult Bio-Science Foundation , The Research Foundation for Pharmaceutical Sciences , and by research grants from the Kitasato University, School of Medicine , Parents' Association Grant of Kitasato University, School of Medicine , and the Japan Agency for Medical Research and Development ( JP 20fk0108139 ). Publisher Copyright: © 2021 Elsevier Ltd
N2 - Recurrent Clostridioides difficile infection (rCDI) is a frustrating condition that may affect a person's quality of life for months. Microbiome-based therapy such as fecal microbiota transplantation (FMT) has been effective for the treatment of rCDI by correcting the imbalance of the gut microbiota. Appropriate antibiotic treatment is recommended for at least two recurrences before offering FMT. Here, we report the case of a 92-year-old woman who experienced five recurrences of Clostridioides difficile infection (CDI) (six episodes in total) complicated by dementia and delirium, both of which were dramatically improved by FMT, which was associated with alterations in fecal microbiota and the metabolome. Analyses of whole microbial communities and metabolomic analyses were performed on stool specimens collected from the patient on the first episode, the third episode, the day of FMT (before FMT), and 2, 8, and 23 weeks after the FMT and from the donor. The patient had various fecal dysbioses on the first and third episodes and on the day of FMT. Two weeks after FMT, diversity of the gut bacteriome as well as the virome increased dramatically and was reflected in a positive clinical outcome for this patient. Metabolomic analysis revealed that short-chain fatty acids, which have been reported to be associated with improved memory function, were increased after FMT.
AB - Recurrent Clostridioides difficile infection (rCDI) is a frustrating condition that may affect a person's quality of life for months. Microbiome-based therapy such as fecal microbiota transplantation (FMT) has been effective for the treatment of rCDI by correcting the imbalance of the gut microbiota. Appropriate antibiotic treatment is recommended for at least two recurrences before offering FMT. Here, we report the case of a 92-year-old woman who experienced five recurrences of Clostridioides difficile infection (CDI) (six episodes in total) complicated by dementia and delirium, both of which were dramatically improved by FMT, which was associated with alterations in fecal microbiota and the metabolome. Analyses of whole microbial communities and metabolomic analyses were performed on stool specimens collected from the patient on the first episode, the third episode, the day of FMT (before FMT), and 2, 8, and 23 weeks after the FMT and from the donor. The patient had various fecal dysbioses on the first and third episodes and on the day of FMT. Two weeks after FMT, diversity of the gut bacteriome as well as the virome increased dramatically and was reflected in a positive clinical outcome for this patient. Metabolomic analysis revealed that short-chain fatty acids, which have been reported to be associated with improved memory function, were increased after FMT.
U2 - 10.1016/j.anaerobe.2021.102502
DO - 10.1016/j.anaerobe.2021.102502
JO - Anaerobe
JF - Anaerobe
Gotoh K, Sakaguchi Y, Kato H, Osaki H, Jodai Y, Wakuda M et al. Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome. Anaerobe. 2022 Feb;73:102502. doi: 10.1016/j.anaerobe.2021.102502