More info on CLIC5
CLIC5: Wikis
Categories: Ion channels
Chloride intracellular channel 5
CLIC5; CLIC5B; FLJ90663; MST130; MSTP130; dJ447E21.4
OMIM: 607293 MGI: 1917912 HomoloGene: 987 GeneCards: CLIC5 Gene
• voltage-gated chloride channel activity
• protein binding
• chloride ion binding
• insoluble fraction
• microvillus
• actin cytoskeleton
• membrane
• ion transport
• chloride transport
• female pregnancy
RNA expression pattern
More reference expression data
ENSG00000112782 ENSMUSG00000023959
Q9NZA1 Q8BXK9
NM_016929 NM_172621
Chr 6:
45.98 - 46.16 Mb Chr 17:
43.65 - 43.74 Mb
Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene.[1][2] Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli.[supplied by OMIM][2]It can form ion channel in bilayers and is regulated by actin.
^ Berryman M, Bretscher A (Aug 2000). "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli". Mol Biol Cell 11 (5): 1509-21. PMID 10793131.
^ a b "Entrez Gene: CLIC5 chloride intracellular channel 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53405.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.
Suzuki T, Morita R, Sugimoto Y, et al. (2002). "Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5.". Epilepsy Res. 50 (3): 265–75. doi:10.1016/S0920-1211(02)00052-9. PMID 12200217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Berryman M, Bruno J, Price J, Edwards JC (2004). "CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.". J. Biol. Chem. 279 (33): 34794–801. doi:10.1074/jbc.M402835200. PMID 15184393.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gonzalez A, Ciobanu D, Sayers M, et al. (2007). "Gene transcript amplification from cell lysates in continuous-flow microfluidic devices.". Biomedical microdevices 9 (5): 729–36. doi:10.1007/s10544-007-9083-1. PMID 17492382.
Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.". FEBS J. 274 (24): 6306–6316. PMID 18028448.
MeSH CLIC5+protein,+human
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Membrane transport protein: ion channels
Ca2+: Calcium channel
Voltage-gated
L-type/Cavα (1.1, 1.2, 1.3, 1.4) · N-type/Cavα2.2 · P-type/Cavα(2.1) · Q-type/Cavα2.1 · R-type/Cavα2.3 · T-type/Cavα(3.1, 3.2, 3.3)
α2δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)
Ligand-gated
Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Navβ (1, 2, 3, 4)
Constitutively active
Epithelial sodium channel (α, β, γ, δ)
K+: Potassium channel
Kvα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4)
Kvα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3)
Kvβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene
Calcium-activated
BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · KCa ( 1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
Inward-rectifier
Kir (1.1, 2.1, 2.2, 2.3, 2.4) · GIRK/ Kir (3.1, 3.2, 3.3, 3.4) · Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
Tandem pore domain
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)
Cyclic nucleotide-gated (FC)
α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)
Porin
Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family
Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel
see also disorders
Categories: Human proteins | Chromosome 6 gene stubs | Ion channels
Hidden categories: Wikipedia articles incorporating text from the United States National Library of Medicine
Entrez Gene: CLIC5 chloride intracellular channel 5