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The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism
Benjamin Metz, Ronald P de Vries, Stefan Polak, Verena Seidl, Bernhard Seiboth
Onderzoeksoutput: Bijdrage aan wetenschappelijk tijdschrift/periodieke uitgave › Artikel › Wetenschappelijk › peer review
The Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery.
FEBS Letters
Gepubliceerd - 17 apr 2009
10.1016/j.febslet.2009.03.027
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Mannitol Dehydrogenases Medicine & Life Sciences 100%
L-Xylulose Chemical Compounds 99%
Hypocrea Medicine & Life Sciences 96%
Trichoderma Medicine & Life Sciences 76%
L-Arabinose Chemical Compounds 73%
D-Mannitol Chemical Compounds 71%
Arabinose Medicine & Life Sciences 70%
L-xylulose reductase Medicine & Life Sciences 68%
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Metz, B., de Vries, R. P., Polak, S., Seidl, V., & Seiboth, B. (2009). The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism. FEBS Letters, 583(8), 1309-13. https://doi.org/10.1016/j.febslet.2009.03.027
Metz, Benjamin ; de Vries, Ronald P ; Polak, Stefan ; Seidl, Verena ; Seiboth, Bernhard. / The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism. In: FEBS Letters. 2009 ; Vol. 583, Nr. 8. blz. 1309-13.
@article{db28ec9333424aa79d35723fb3751c70,
title = "The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism",
abstract = "The Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery.",
keywords = "Arabinose, Genes, Fungal, Mannitol Dehydrogenases, Trichoderma",
author = "Benjamin Metz and {de Vries}, {Ronald P} and Stefan Polak and Verena Seidl and Bernhard Seiboth",
doi = "10.1016/j.febslet.2009.03.027",
pages = "1309--13",
journal = "FEBS Letters",
publisher = "Elsevier B.V.",
Metz, B, de Vries, RP, Polak, S, Seidl, V & Seiboth, B 2009, 'The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism', FEBS Letters, vol. 583, nr. 8, blz. 1309-13. https://doi.org/10.1016/j.febslet.2009.03.027
The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism. / Metz, Benjamin; de Vries, Ronald P; Polak, Stefan; Seidl, Verena; Seiboth, Bernhard.
In: FEBS Letters, Vol. 583, Nr. 8, 17.04.2009, blz. 1309-13.
T1 - The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism
AU - Metz, Benjamin
AU - de Vries, Ronald P
AU - Polak, Stefan
AU - Seidl, Verena
AU - Seiboth, Bernhard
N2 - The Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery.
AB - The Hypocrea jecorina LXR1 was described as the first fungal L-xylulose reductase responsible for NADPH dependent reduction of L-xylulose to xylitol in L-arabinose catabolism. Phylogenetic analysis now reveals that LXR1 forms a clade with fungal D-mannitol 2-dehydrogenases. Lxr1 and the orthologous Aspergillus niger mtdA are not induced by L-arabinose but expressed at low levels during growth on different carbon sources. Deletion of lxr1 does not affect growth on L-arabinose and L-xylulose reductase activity remains unaltered whereas D-mannitol 2-dehydrogenase activities are reduced. We conclude that LXR1 is a D-mannitol 2-dehydrogenase and that a true LXR1 is still awaiting discovery.
KW - Arabinose
KW - Genes, Fungal
KW - Mannitol Dehydrogenases
KW - Trichoderma
U2 - 10.1016/j.febslet.2009.03.027
DO - 10.1016/j.febslet.2009.03.027
JO - FEBS Letters
JF - FEBS Letters
Metz B, de Vries RP, Polak S, Seidl V, Seiboth B. The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism. FEBS Letters. 2009 apr 17;583(8):1309-13. https://doi.org/10.1016/j.febslet.2009.03.027
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