Department of Nephrology and Rheumatology
Peter Korsten
Universitätsmedizin Göttingen · Department of Nephrology and Rheumatology
Doctor of Medicine (M.D.)
Focusing on clinical outcome research in Systemic Diseases, such as Systemic Sclerosis, SLE, Myositis, and Sarcoidosis.
Peter Korsten currently works at the Department of Nephrology and Rheumatology, Universitätsmedizin Göttingen. Peter does research in Emergency Medicine/Critical Care, Nephrology, and Rheumatology. He has a special interest in rare systemic diseases, such as Sarcoidosis, Systemic Lupus erythematosus, and Systemic Sclerosis. Current research projects include 'Circulating CpG DNA in Lupus nephritis' and 'Outcome of immunosuppressive therapy in CTD-ILD'.
Clinical Nephrology
October 2016 - present
Task force member
April 2016 - October 2020
Göttingen, Germany
Rheumatologist I Intensivist
Nephrology and Rheumatology
Nursing education in Nephrology and Critical Care
Nephrology and Rheumatology, Critical Care, Emergency Medicine
Hospital Civil de Guadalajara Juan I. Menchaca
Internship in Ob/Gyn and Internal Medicine
July 2007 - October 2007
Sana Kliniken Düsseldorf
Internship Surgery
Renal disease in sarcoidosis patients in a German multicentric retrospective cohort study
Raoul Bergner
Stefan M. Weiner
Gabriele Kehl
Editorial: Multidisciplinary Critical Care Medicine - Getting Things Done Across Specialties
Björn Tampe
Reproducibility and rigor in rheumatology research
Fatima Alnaimat
Nadia Sweis
Jaleel Jerry G. Sweis
Nadera Sweiss
The pillars of scientific progress in rheumatology are experimentation and observation, followed by the publication of reliable and credible results. These data must then be independently verified, validated, and replicated. Peer and journal-specific technical and statistical reviews are paramount to improving rigor and reproducibility. In addition...
Myositis
Eugen Feist
Zusammenfassung Unter der Federführung der Deutschen Gesellschaft für Neurologie und Beteiligung vieler weiterer Fachgesellschaften wurde die S2k-Leitlinie zu Myositissyndromen vollständig aktualisiert und überarbeitet. Bei der Klassifikation der Myositiden werden nun die immunmediierte nekrotisierende Myopathie und das Antisynthetasesyndrom als ei...
Systemic Sclerosis Associated Interstitial Lung Disease: A Conceptual Framework for Subclinical, Clinical, and Progressive Disease
David Roofeh
Kevin K Brown
Ella A Kazerooni
Dinesh Khanna
Objectives: Establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). Methods: A conceptual framework for subclinical, clinical, and progressive ILD was provided to eighty-three experts, asking them to use the framework and classify actual SSc-ILD patients. Each patient pr...
Anti-acid therapy in SSc-associated interstitial lung disease: long-term outcomes from the German Network for Systemic Sclerosis
Michael Kreuter
Francesco Bonella
Nobert Blank
Nicolas Hunzelmann
Objectives: Gastroesophageal reflux disease (GERD) occurs frequently in patients with systemic sclerosis (SSc). We investigated whether the presence of GERD and/or the use of anti-acid therapy, specifically proton-pump inhibitors (PPIs), are associated with long-term outcomes, especially in SSc-associated interstitial lung disease (SSc-ILD). Meth...
PO.5.101 The effect of belimumab on renal outcomes in a pre-specified subgroup analysis of a phase 3 randomised trial in a european population with lupus nephritis
Laura Andreoli
Z Amoura
E Morales
Purpose To evaluate the efficacy and safety of intravenous (IV) belimumab (BEL) in the European subgroup of patients with lupus nephritis (LN) from the previously published BLISS-LN study.1 Methods BLISS-LN was a Phase 3, double-blind, placebo (PBO)-controlled 104-week study (GSK Study BEL114054; NCT01639339). Adult patients with biopsy-proven LN...
Editorial: Sarcoidosis—The great mimicker
Mehdi Mirsaeidi
Clinical Vignette: IRF6 mutation in systemic sclerosis – innocent bystander or contributing factor?
Jan-Gerd Rademacher
A 42-year-old woman with systemic sclerosis presented to our clinic. The diagnosis was based on sclerodactyly, mutilating arthritis, interstitial lung disease and positive antibodies (ANA, Scl70). She reported progressive dyspnoea and debilitating joint pain. Her medical history included surgery for cleft lip/palate (CL/P); a surgically corrected C...
Rapid Response of Refractory Systemic Lupus Erythematosus Skin Manifestations to Anifrolumab—A Case-Based Review of Clinical Trial Data Suggesting a Domain-Based Therapeutic Approach
Marlene Plüß
Silvia Piantoni
Chris Wincup
Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease, and organ manifestations, such as lupus nephritis (LN) or skin disease, may be refractory to standard treatment. Therefore, new agents are required to allow for a more personalized therapeutic approach. Recently, several new therapies have been approved internation...
POS0929 MICRO VASCULAR IMAGING AS A NOVEL TOOL TO QUANTIFY BLOOD FLOW IN THE FINGERTIPS IN PATIENTS WITH SYSTEMIC SCLEROSIS VS. HEALTHY CONTROLS: A SINGLE-CENTER FEASIBILITY STUDY
R. M. Buschfort
Background Systemic sclerosis (SSc) is characterized by tissue fibrosis and vasculopathy. Raynaud's phenomenon is present in almost all patients (1). Nailfold video capillaroscopy is an established imaging tool for a morphologic assessment but is not able to quantify blood flow (2). Micro Vascular Imaging (MVI) is a novel ultrasound technique for b...
Rapid Response of Refractory Systemic Lupus Erythematosus Skin Manifestations to Anifrolumab – A Case-Based Review of Clinical Trial Data Suggesting A Domain-Based Therapeutic Approach
Belimumab for Systemic Lupus Erythematosus – focus on Lupus Nephritis
In recent years, advances in the treatment and the management of patients with systemic lupus erythematosus (SLE) have improved their life expectancy and quality of life. However, lupus nephritis (LN) still represents a major life-threatening complication of the disease. Belimumab (BEL), a fully human monoclonal IgG1λ antibody neutralizing soluble...
pANCA autoantibody testing by indirect immunofluorescence indicates interstitial arteritis independent of MPO-ANCA immunoassays in ANCA-associated glomerulonephritis
Samy Hakroush
Ingmar Alexander Kluge
Eva Baier
The discovery of antineutrophil cytoplasmic antibodies (ANCAs) in ANCA-associated vasculitis (AAV) marked a breakthrough in diagnostics. Subsequently, ANCAs were found in distinct small vessel vasculitides, including microscopic polyangiitis (MPA) and eosinophilic GPA (formerly known as Churg-Strauss syndrome). The current recommended diagnostic ap...
40620_2022_1320_MOESM1_ESM.pdf
Ansprechen eines mit rheumatoider Arthritis assoziierten Pyoderma gangraenosum auf den JAK1‐Inhibitor Upadacitinib
Neda Rahbar Kooybaran
Michael P. Schön
Rotraut Mössner
Study Protocol: A Randomized Controlled Prospective Single-Center Feasibility Study of Rheopheresis for Raynaud's Syndrome and Digital Ulcers in Systemic Sclerosis (RHEACT Study)
Angela Borisch
Introduction Raynaud's phenomenon (RP) and digital ulcers (DU) are frequent manifestations of Systemic Sclerosis (SSc). Despite being very common in SSc patients, both conditions have proven to be notoriously difficult to study. There are very few available approved drugs with varying efficacy. It has been shown that the presence of DU is associate...
Response of rheumatoid arthritis-associated pyoderma gangrenous to the JAK1 inhibitor upadacitinib
Comparison of liver stiffness in patients with systemic sclerosis and primary biliary cirrhosis: a prospective single-center cohort study
Viktor Korendovych
Golo Petzold
- Patients with SSc without PBC do not have increased liver stiffness compared to healthy controls - Patients with SSc/PBC overlap and PBC have comparable liver stiffness - PBC, if present, is the main driver of increased liver stiffness/fibrosis in SSc/PBC overlap patients
Sarcoidosis: rheumatological manifestations
Comparative analysis of SGLT-2 expression in renal vasculitis and lupus nephritis
Desiree Tampe
The nephroprotective efficacy of sodium-glucose cotransporter-2 (SGLT-2) inhibitors (SGLT-2i) in patients with chronic kidney disease, with or without type 2 diabetes, has already been described.1 Although patients with autoimmune diseases were excluded from large renal outcome trials, the use of SGLT-2i in antineutrophil cytoplasmic antibody-assoc...
Supplemental material for annrheumdis-2022-222167
Microvascular Imaging as a Novel Tool for the Assessment of Blood Flow Velocity in Patients with Systemic Sclerosis: A Single-Center Feasibility Study
Rosa Marie Buschfort
Thomas Asendorf
Systemic sclerosis is an autoimmune disease characterized by organ fibrosis and vasculopathy. Almost all patients suffer from Raynaud's phenomenon. Nailfold video capillaroscopy is the most widely imaging technique available, but flow quantification is impossible. Therefore, novel imaging techniques are of interest. We performed a single-center fea...
Rituximab -a B cell targeted therapy in Systemic Lupus Erythematosus: where do we stand?
Rituximab-a B cell target therapy in Systemic Lupus Erythematosus: where do we stand?
Fulminant Lyme myocarditis without any other signs of Lyme disease in a 37-year-old male patient with microscopic polyangiitis-a case report
Marco R Schroeter
Karin Klingel
Gerd Hasenfuß
Background Lyme disease is a tick-borne multisystem infection. The most common cardiac manifestation is an acute presentation of Lyme carditis, which often manifests as conduction disorder and rarely as myocarditis. Case Summary We report the case of a 37-year-old male with a history of microscopic polyangiitis receiving immunosuppressive therapy....
Treatment and outcomes in anti-HMG-CoA reductase-associated immune-mediated necrotising myopathy. Comparative analysis of a single-centre cohort and published data
Stefanie Glaubitz
Sabrina Zechel
OBJECTIVES: Anti-hydroxy-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody-associated myopathy was recognised as a new form of immune-mediated necrotising myopathy (IMNM) a decade ago. Due to the rarity of the disease, only limited data on clinical manifestations and therapeutic outcomes are available. METHODS: We retrospectively analysed a mo...
Kinetics of Bilirubin and Ammonia Elimination during Hemadsorption Therapy in Secondary Sclerosing Cholangitis Following ECMO Therapy and Severe COVID-19
Sebastian C. B. Bremer
In critically ill patients, liver dysfunction often results in coagulopathy and encephalopathy and is associated with high mortality. Extracorporeal clearance of hepatotoxic metabolites, including bilirubin and ammonia, aims to attenuate further hepatocyte damage and liver injury, resulting in decreased mortality. The efficacy of hemadsorption comb...
Superb Micro Vascular Imaging as a Novel Tool for the Assessment of Blood Flow Velocity in Patients with Systemic Sclerosis: A Single-Center Feasibility Study
Systemic sclerosis is an autoimmune disease characterized by organ fibrosis and vasculopathy. Almost all patients suffer from Raynaud's phenomenon. Nailfold video capillaroscopy is the most widely available imaging technique, but flow quantification is impossible. Therefore, novel imaging techniques are of interest. We performed a single-center fea...
Introducing the international Myositis Society (iMyoS): a novel multiprofessional society to foster the care, education and research on myositis
Jens Schmidt
Silke Schlüter
First Report of Two Cases of Löfgren's Syndrome after SARS-CoV-2 Vaccination-Coincidence or Causality?
Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren's syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, repor...
Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis
Philipp Ströbel
Background: Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), potentially leading to chronic kidney disease (CKD), end-stage renal disease (ESRD), or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) and myeloperoxidase (MPO), trigger a deleterious immu...
Low Efficacy of Chromogranin A Elimination by Therapeutic Plasma Exchange for Treatment of Chromogranin A Tubulopathy
Laura Schridde
Manuel Wallbach
Previous seminal work has shown that chromogranin A (CgA) can mediate tubular injury, either by intraluminal precipitation with cast formation or excessive tubular CgA uptake. We report an additional case of kidney injury in the context of CgA tubulopathy and explored the efficacy of CgA elimination by therapeutic plasma exchange (PEX). A 69-year-o...
Comprehensive Analysis of Sex Differences at Disease Manifestation in ANCA-Associated Glomerulonephritis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis affecting multiple organ systems, including the kidney. Besides investigations focusing on renal outcomes, sex differences associated with distinct clinical and histopathological findings in ANCA glomerulonephritis (GN) have not been systematically...
Sarcoidosis Following Hematopoietic Stem Cell Transplantation: Clinical Characteristics and HLA Associations
Rebecca Isabell Wurm-Kuczera
Judith Büntzel
Julia Felicitas Leni Koenig
Gerald G Wulf
Purpose: Extrinsic factors and genetic predisposition contribute to the etiology of sarcoidosis, converging in a phenotype of altered immune response associated with multisystemic inflammatory granulomatous tissue infiltration. Immunological reconstitution after hematopoietic stem cell transplantation (HSCT) may represent a unique window for the pa...
Therapie und Outcome einer monozentrischen Patientenkohorte mit Anti-HMG-CoA-Reduktase-Antikörper immunvermittelter nekrotisierender Myopathie
Shear Wave Elastographie zum nicht-invasiven Assessment von Leberfibrose bei Patienten mit systemischer Sklerodermie und primär biliärer Zirrhose
Lupus nephritis in male and female patients: Same same but different?
Noah Niebusch
Das Sarcoidosis-Lymphoma Syndrome als seltene Entität bei Patienten mit systemischer Symptomatik -eine systematische Literaturübersicht
Nils Schubert
The Rapid Atrial Swirl Sign for Ultrasound-Guided Tip Positioning of Retrograde-Tunneled Hemodialysis Catheters: A Cross-Sectional Study from a Single Center
Tim Kuczera
Background: Chronic kidney disease (CKD) is a common medical problem in patients worldwide, with an increasing prevalence of patients with end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT). In patients requiring RRT for more than two weeks or those who develop ESKD, tunneled hemodialysis catheter (HDC) insertion is preferre...
Different Patterns of Kidney Fibrosis Are Indicative of Injury to Distinct Renal Compartments
Kidney fibrosis is a common manifestation and hallmark of a wide variety of chronic kidney disease (CKD) that appears in different morphological patterns, suggesting distinct pathogenic causes. Broad macroscopically visible scars are the sequelae of severe focal injury and complete parenchymal destruction, reflecting a wound healing response as a c...
Anti–Jo-1 Syndrome Often Misdiagnosed as Rheumatoid Arthritis (for Many Years)—A Single-Center Experience Think of RA-ASyS Overlap!
Julia Felicitas Leni König
Purpose Extrinsic factors and genetic predisposition contribute to the etiology of sarcoidosis, converging in a phenotype of altered immune response associated with multisystemic inflammatory granulomatous tissue infiltration. Immunological reconstitution after hematopoietic stem cell transplantation (HSCT) may represent a unique window for the pat...
Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases
Jonathan Samuel Hausmann
Kevin Kennedy
Julia F Simard
Moré A. Kodek
Background The impact and consequences of the COVID-19 pandemic on people with rheumatic disease are unclear. We developed the COVID-19 Global Rheumatology Alliance Patient Experience Survey to assess the effects of the COVID-19 pandemic on people with rheumatic disease worldwide. Methods Survey questions were developed by key stakeholder groups a...
Impact of the COVID-19 Pandemic on Kidney Diseases Requiring Renal Biopsy: A Single Center Observational Study
Background The coronavirus disease-2019 (COVID-19) pandemic impacted healthcare services for kidney disease patients. Lockdown and social distancing were mandated worldwide, resulting in closure of medical services. The diagnosis of various kidney diseases may have been delayed during the COVID-19 pandemic because non-urgent tests and visits were p...
Complement Components C3 and C4 Indicate Vasculitis Manifestations to Distinct Renal Compartments in ANCA-Associated Glomerulonephritis
Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) causing progressive chronic kidney disease (CKD), end-stage renal disease (ESRD) or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) and myeloperoxidase (MPO), trigger a deleterious immune response resul...
Systematic Scoring of Tubular Injury Patterns Reveals Interplay between Distinct Tubular and Glomerular Lesions in ANCA-Associated Glomerulonephritis
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Acute tubular injury with the presence of tubulitis was previously reported to be of prognostic value in ANCA glomerulonephritis (GN)...
Consideration of Therapeutic Plasma Exchange in Association With Inflammatory Lesions in ANCA-Associated Glomerulonephritis: A Real-World Retrospective Study From a Single Center
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Pathogenic ANCAs trigger a deleterious immune response resulting in pauci-immune necrotizing and crescentic glomerulonephritis (GN). Standard therap...
ERS clinical practice guidelines on treatment of sarcoidosis
Robert P. Baughman
Dominique Valeyre
Daniel R. Ouellette
Background: The major reasons to treat sarcoidosis are to lower the morbidity and mortality risk or to improve quality of life (QoL). The indication for treatment varies depending on which manifestation is the cause of symptoms: lungs, heart, brain, skin or other manifestations. While glucocorticoids remain the first choice for initial treatment o...
POS0722 HISTOPATHOLOGICAL ANALYSIS OF LUPUS NEPHRITIS INCORPORATING BANFF CRITERIA EMPHASIZES THE IMPORTANCE OF TUBULOINTERSTITIAL CHANGES FOR CREATININE AND PROTEINURIA AT 12 MONTHS AFTER RENAL BIOPSY
M. Plüß
Background Lupus nephritis (LN) occurs in about 30-60% of patients with systemic lupus erythematosus (SLE). LN is associated with increased mortality. Currently, the diagnosis relies on histopathologic characteristics according to the ISN/RPS classification (1). This classification relies heavily on glomerular changes and may not accurately reflect...
POS0834 LONG-TERM OUTCOME OF SSC ASSOCIATED ILD: IMPROVED SURVIVAL IN PPI TREATED PATIENTS
M. Kreuter
K. Kathrin
N. Hunzelmann
Background Gastroesophageal reflux disease (GERD) occurs frequently in patients with systemic sclerosis (SSc) and SSc-associated interstitial lung disease (SSc-ILD). PPI use has to been shown to improve survival in patients with idiopathic pulmonary fibrosis, whereas to date there are no data on the use of PPI in SSc-ILD. Objectives This study was...
POS0825 DEVELOPMENT OF A NEW AND SIMPLIFIED FORMULA TO PREDICT MORTALITY IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS ADMITTED TO THE INTENSIVE CARE UNIT
F. Kück
K. Tejiozem Donfack
Background ANCA-associated vasculitis (AAV) can present with a wide range of symptoms, including acute kidney injury (AKI) requiring renal replacement therapy or diffuse alveolar hemorrhage (1). These two manifestations often require admission to an intensive care unit (ICU) and are associated with increased mortality. To predict ICU mortality, the...
AB0818 ADVERSE EVENTS UNDER B-CELL DIRECTED THERAPIES IN A LARGE SINGLE-CENTER COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS, ANCA-ASSOCIATED VASCULITIS AND RENAL DISEASES
Background The anti-CD20 antibody rituximab (RTX) is approved for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV). In addition, RTX is used in a wide range of autoimmune diseases. Belimumab (BEL) is an anti-BAFF antibody approved for the treatment of non-renal systemic lupus erythematosus (SLE) in Europe. These agent...
AB0283 CHOREOATHETHOSIS AND LONGITUDINALLY EXTENSIVE TRANSVERSE MYELITIS AS RARE AND SEVERE MANIFESTATIONS OF NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS AND PRIMARY SJÖGREN'S SYNDROME – A TWO-CENTER EXPERIENCE
Background Systemic lupus erythematosus (SLE) can affect almost any organ system. Nevertheless, Lupus nephritis and neuropsychiatric manifestations (NPSLE) are associated with increased mortality (1). Therapeutic options include glucocorticoids, often pulse methylprednisolone (MP), and other immunosuppressive therapies. In refractory cases, therape...
AB0418 SHEAR WAVE ELASTOGRAPHY FOR THE ASSESSMENT OF LIVER FIBROSIS IN PATIENTS WITH SYSTEMIC SCLEROSIS AND SYSTEMIC SCLEROSIS/PRIMARY BILIARY CHOLANGITIS OVERLAP COMPARED TO PRIMARY BILIARY CHOLANGITIS
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and skin as well as organ fibrosis. The lungs, skin, and gastrointestinal care frequently affected. Primary biliary cholangitis (PBC) is an autoimmune disease of the liver associated with potential progression to liver fibrosis. More recently, these two disor...
Correspondence on 'Second COVID-19 infection in a patient with granulomatosis with polyangiitis on rituximab'
Klinische Manifestation der extrapulmonalen Sarkoidose im Kopf-Hals-Bereich
Thorsten Send
M Bertlich
Sebastian Strieth
Clinical features of sarcoidosis patients presenting with head and neck manifestations
Mattis Bertlich
COVID-19 and Sarcoidosis, Readiness for Vaccination: Challenges and Opportunities
Michael Manansala
Robert P Baughman
Sarcoidosis is an immune mediated chronic inflammatory disorder that is best characterized by non-caseating granulomas found in one or more affected organs. The COVID-19 pandemic poses a challenge for clinicians caring for sarcoidosis patients who may be at increased risk of infection compared to the general population. With the recent availability...
Incorporation of Banff classification in Lupus nephritis histopathology assessment emphasizes the importance of tubulointerstitial changes
Lupus nephritis (LN) occurs in about 30-60% of patients with SLE. Currently, the diagnosis relies on histopathologic characteristics according to the ISN/RPS classification but is centered on glomerular changes. For the description of transplanted kidneys, the BANFF classification has been established which also incorporates tubulointerstitial find...
Treatment and outcomes of severe Neuropsychiatric Lupus and Neuro-Sjögren manifestations – a two-center experience
Neuropsychiatric manifestations (NPSLE) are associated with increased mortality and can be particularly difficult to treat. Severe manifestations include movement disorders and transverse myelitis (TM), which can also occur in primary Sjögren's syndrome (pSS). We retrospectively analyzed clinical data and outcomes in NPSLE and pSS at two academic c...
Adverse events with intravenous Belimumab are low in clinical practice – analysis of a single-center cohort
Immunosuppressive therapy with Belimumab is employed in SLE patients with active disease (high SLEDAI, glucocorticoid dependency, high serological activity) and has a potential for serious adverse events, including infections or laboratory changes. Here, we report our experience of reported adverse events with Belimumab in a single-center academic...
Bowman's capsule rupture links glomerular damage to tubulointerstitial inflammation in ANCA-associated glomerulonephritis
Objectives: We have recently described the frequency of Bowman's capsule (BC) rupture in a considerable subset of patients with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). Interestingly, recent reports established a better performance of glomerulocentric ANCA scoring systems after adding BC rupture to these classi...
Proteinuria Indicates Decreased Normal Glomeruli in ANCA-Associated Glomerulonephritis Independent of Systemic Disease Activity
Background: Renal involvement is a common and severe complication of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), potentially resulting in a pauci-immune necrotizing and crescentic ANCA glomerulonephritis (GN) with acute kidney injury (AKI), end-stage renal disease (ESRD) or death. There is recent evidence that the degre...
Systemischer Lupus erythematodes und primäres Sjögren-Syndrom: On- und Off-Label-Therapie – aktueller Stand 2021
Johanna Mucke
ZUSAMMENFASSUNG Die Therapie des systemischen Lupus erythematodes (SLE) und des primären Sjögren-Syndroms (pSS) stellt eine Herausforderung dar. Dies liegt nicht nur an der Heterogenität der Ausprägung beider Erkrankungen, sondern auch an den wenigen erprobten und zugelassenen Therapiemöglichkeiten. Für die Behandlung des SLE zugelassen sind Hydrox...
Systematic Histological Scoring Reveals More Prominent Interstitial Inflammation in Myeloperoxidase-ANCA Compared to Proteinase 3-ANCA Glomerulonephritis
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Kidney involvement is a common and severe complication of ANCA AAV which is observed in a considerable subset of patients, mainly affect...
Improvement of Lupus-associated fatigue with modafinil: report of two cases
Fatigue is a frequently reported and disabling symptom in patients with systemic lupus erythematosus (SLE). The management of Lupus-associated fatigue (LAF) is complex and requires the exclusion of disease activity and comorbidities as potentially treatable causes. Standard of care recommendations includes psychological counselling and regular phys...
DataSheet_1_Variable Expression of Programmed Cell Death Protein 1-Ligand 1 in Kidneys Independent of Immune Checkpoint Inhibition.pdf
Sarah Birgit Kopp
Correspondence on 'Preliminary predictive criteria for COVID-19 cytokine storm'
Martin Sebastian Winkler
Editorial: Interstitial Lung Disease in the Context of Systemic Disease: Pathophysiology, Treatment and Outcomes
Maximilian F. Konig
Histopathological Findings Predict Renal Recovery in Severe ANCA-Associated Vasculitis Requiring Intensive Care Treatment
Renal involvement is a common and severe complication of AAV as it can cause ESRD. Histopathological subgrouping and ARRS are helpful to predict long-term ESRD in patients with AAV. Because a subgroup of critically ill patients with severe AAV present with deterioration of kidney function requiring dialysis at admission, we here aimed to evaluate h...
Antisynthetase Syndrome-Associated Interstitial Lung Disease: Monitoring of Immunosuppressive Treatment Effects by Chest Computed Tomography
Linn Riedel
Radovan Vasko
Background Antisynthetase syndrome (ASyS) is a rare autoimmune disease characterized by inflammatory myopathy, arthritis, fever, and interstitial lung disease (ILD). Pulmonary involvement in ASyS significantly increases morbidity and mortality and, therefore, requires prompt and effective immunosuppressive treatment. Owing to the rarity of ASyS, li...
Variable Expression of Programmed Cell Death Protein 1-Ligand 1 in Kidneys Independent of Immune Checkpoint Inhibition
Context: Due to recent advantages in cancer therapy, immune checkpoint inhibitors (ICIs) are new classes of drugs targeting programmed cell death protein 1 (PD-1) or its ligand programmed cell death protein 1-ligand 1 (PD-L1) used in many cancer therapies. Acute interstitial nephritis (AIN) is a potential and deleterious immune-related adverse even...