Uterine Perforation
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A hole or break through the wall of the UTERUS, usually made by the placement of an instrument or INTRAUTERINE DEVICES.
Perforation, Uterine; Perforations, Uterine; Uterine Perforations
Networked: 315 relevant articles (8 outcomes, 11 trials/studies)
Female Urogenital Diseases and Pregnancy Complications
Female Urogenital Diseases
Female Genital Diseases: 236
Uterine Diseases: 242
Uterine Rupture: 823
Uterine Perforation: 315
Wounds and Injuries: 94065
Rupture: 18017
1. Infection
2. Hemorrhage
3. Abscess
4. Septic Abortion
5. Lacerations
1. Promsonthi, Patama: 3 articles (01/2015 - 01/2009)
2. Chanrachakul, Boonsri: 3 articles (01/2015 - 01/2009)
3. Harrison-Woolrych, Mira: 3 articles (01/2011 - 01/2003)
4. Yu, Dan: 3 articles (07/2005 - 05/2003)
5. Duan, Hua: 3 articles (07/2005 - 05/2003)
6. Zheng, Jie: 3 articles (07/2005 - 05/2003)
7. Xia, En-lan: 3 articles (07/2005 - 05/2003)
8. Lemyre, Madeleine: 2 articles (04/2015 - 01/2012)
9. Ki, K D: 2 articles (01/2015 - 01/2012)
10. Seol, H J: 2 articles (01/2015 - 01/2012)
Drugs and Important Biological Agents (IBA) related to Uterine Perforation:
1. Oxidized CelluloseIBA
12/01/2003 - "To test the efficacy and safety of laparoscopic oxidized cellulose application at the uterine perforation site. "
12/01/2003 - "Laparoscopic oxidized cellulose application appears to be a safe and effective treatment for small uterine perforations that are bleeding moderately."
12/01/2003 - "Laparoscopic oxidized cellulose (Surgicel) application for small uterine perforations."
2. Levonorgestrel (Plan B)FDA LinkGeneric
11/01/2011 - "After examination and treatment in an out-patient department, a 38-year-old woman was referred to our hospital due to suspected spontaneous uterine perforation caused by hormonal IUD (Mirena) one month after its application. "
03/01/2006 - "To determine an estimated incidence of uterine perforations related to the insertion of a levonorgestrel-releasing intrauterine system (LNG IUS) and to identify possible risk factors. "
03/01/2006 - "Uterine perforation in women using a levonorgestrel-releasing intrauterine system."
08/01/2004 - "Management of levonorgestrel-releasing intrauterine system (LNG-IUS) uterine perforation."
07/01/2003 - "Approximately, 2% of the Mirena insertions were carried out under GA and there were three uterine perforations (0.9 per 1000 insertions) in the total cohort. "
3. CopperIBA
01/01/1975 - "A study of uterine perforation by Copper-T and Copper-7 IUDs is described. "
04/01/2015 - "Overall, 81 uterine perforations were reported: 61 for LNG-IUSs [1.4 per 1000 insertions (95% confidence interval {CI}: 1.1-1.8)] and 20 for copper IUDs [1.1 per 1000 insertions (95% CI: 0.7-1.7)], for an adjusted risk ratio (RRadj) of 1.6 (95% CI: 1.0-2.7) when adjusted for age, body mass index, breastfeeding at time of insertion and parity. "
07/01/2010 - "The only case of uterine perforation was in the user of Copper-T. "
07/01/1999 - "This article describes a case of uterine perforation which occurred 2 months after the insertion of a Gynefix, a frameless filiform copper IUD inserted into the fundal myometrium. "
06/01/1989 - "No reports of cervical perforation were found, and the uterine perforation rate was 0.12/1000 insertions compared to a rate of 0.68/1000 insertions for other copper-bearing IUDs. "
4. Misoprostol (Cytotec)FDA LinkGeneric
05/12/2012 - "No women in the misoprostol group had cervical tears and three had uterine perforations compared with two women in the placebo group who had cervical tears and one who had perforation. "
09/01/2008 - "This review of our experience with surgical abortion performed from 12 to 16 weeks estimated gestational age following cervical preparation with misoprostol alone shows that the rate of SAEs, specifically uterine perforation, in this group was no greater than that previously reported in the literature."
04/01/2008 - "Uterine perforation occurred in two patients in the oral misoprostol group and in none in the vaginal misoprostol group. "
07/01/2007 - "Cervical injury and uterine perforation occurred in 12 and 3 women respectively in the control group compared to 1 and 0 women respectively in the misoprostol group. "
07/01/2006 - "Uterine perforation as a rare complication of attempted pregnancy termination with misoprostol: a case report."
5. 2,2'-thiobis(ethyl acetoacetate)IBA
01/01/2004 - "In Garfield and colleagues' review: TBEA had significantly shorter operating and theatre times (P < .05, < .01, and .0001).TBEA had fewer intraoperative adverse effects (e.g., reported rates of uterine perforation with RB ablation: from 1% to 5%; TBEA: 0%; rates of cervical laceration with RB: 2% to 5%; TBEA 0%).They found no studies have directly compared second-generation techniques and hysterectomy; therefore, the comparison can only be indirectly inferred from studies of first-generation techniques and hysterectomy.Compared"
01/01/2004 - "This included uterine perforation (RB, 5%; TBEA, 0%) and suspicion of perforation (RB, 2%; TBEA, 0%).A multicentre long-term case series (level 4 evidence) that examined avoidance of hysterectomy after TBEA for menorrhagia reported that 86% of women who had TBEA did not require a hysterectomy, and 75% did not have any further surgery during a follow-up period of 4 to 6 years. "
6. Glycine (Aminoacetic Acid)FDA LinkGeneric
04/01/1997 - "Intra-operative complications were rare, mainly uterine perforations (7 cases) or metabolic syndromes due to reabsorption of glycine (5 cases). "
10/01/1991 - "Complications included uterine perforation in three women, excessive glycine absorption in two, and two women had problems with haemorrhage. "
10/01/2000 - "Operative complications were defined as uterine perforation, excessive glycine absorption (1 L or more), hyponatremia, hemorrhage (500 mL or more), bowel or bladder injury, inability to dilate the cervix, and procedure-related hospital admissions. "
09/30/2001 - "Uterine perforation occurred in three cases (0.9%) (leading to one laparotomy), bleeding in 18 (5.2%), glycine overload in ten (2.9%), and infection in five (1.4%). "
7. Dacarbazine (DIC)FDA LinkGeneric
01/01/2013 - "Serious complications like uterine perforation with or without bowel injury were accounted in 13% of women, septicaemia in 61%, peritonitis in 15% and DIC in 2%. "
01/01/1980 - "Ten women had early complications, mainly fever for a few days; there were no instances of uterine perforations or disseminated intravascular coagulopathy (DIC). "
10/01/2002 - "More medical students cited complications that were technical like uterine perforation (p<0.001), cervical trauma (p<0.001), DIC (p<0.001), and sepsis (p<0.001). "
8. Anti-Bacterial Agents (Antibiotics)IBA
05/01/2001 - "The rates of uterine perforation, blood transfusion, pelvic sepsis requiring intravenous antibiotics, and overnight hospital admission were 0.24, 0, 0.97, and 1.69% respectively. "
05/01/2001 - "The following outcomes were measured: surgical curettage for presumed retained products of conception; continuing pregnancy; uterine perforation; pelvic sepsis requiring intravenous antibiotics; and blood transfusion required. "
08/01/1998 - "Operative complications were 3%; three women had fever and received oral antibiotics; no uterine perforation occurred; one case of post-operative bleeding was controlled by intrauterine balloon inflation; the average operation time was 21 min; The mean fluid deficit was 435 ml. Ninety-nine out of 127 women (78%) had adequately controlled menorrhagia (18.1% had amenorrhea, 42.5% hypomenorrhea and 17.3% had normal menstrual flow), while 27 women (21.2%) were failed due to unchanged or heavier menstrual flow after surgery. "
01/01/1950 - "[Antibiotics in the treatment and prognosis of uterine perforation; observations on the use of associated penicillin and streptomycin]."
9. Syntex adjuvant formulationIBA
03/01/1969 - "The problem of uterine perforation resulting from the insertion of an IUD is reviewed, and 3 personal cases with the Saf-T-Coil 33 S are described. "
11/01/1968 - "Uterine perforation by a SAF-T-coil intrauterine contraceptive device."
10. glucuronyl glucosamine glycan sulfate (Vessel)IBA
12/01/1999 - "There were 3 cases of complications including pulmonary edema and uterine perforation in the resectoscopic myomectomy group, and 4 cases of complications including bladder, ureter, and epigastric vessel injury in the LAVH group. "
03/01/1988 - " Other complications were adnexal injuries in 17, 0.22% (0.04% of minilap); trocar injuries to uterus, retroperitoneum or mesenteric vessel (5 total); skin burn in 1; bladder injuries in 2; and bowel injuries in 4. Minilaparotomy occasioned more uterine perforations related to mobilizing the uterus, and bladder injuries occurring during entering the abdomen. "
1. Blood Transfusion (Blood Transfusions)
09/01/2001 - "There was a high associated morbidity, with 84% requiring hospital admission, 63% surgical evacuation, 17% blood transfusion, with three women suffering a uterine perforation, one managed by hysterectomy. "
01/01/2015 - "There were no serious complications (infection requiring antibiotic treatment, blood transfusion, complications requiring unintended operation, cervical injury, uterine perforation, death or serious morbidity) in the included trials.NO donors were more effective in cervical ripening when compared with placebo or no treatment. "
01/01/2011 - "There were no serious complications (infection requiring antibiotic treatment, blood transfusion, complications requiring unintended operation, cervical injury, uterine perforation, death or serious morbidity) in the trials included.NO donors were more effective in cervical ripening comparing with placebo or no treatment. "
01/01/2009 - "There were no serious complications (infection requiring antibiotic treatment, blood transfusion, complications requiring unintended operation, cervical injury, uterine perforation, death or serious morbidity) in the trials included.NO donors were ineffective in cervical ripening comparing with placebo or no treatment. "
06/01/2005 - "Evaluation criteria were: duration of operation, need for use of forceps, and complications: uterine perforation, cervical laceration, bleeding > 500 ml and need for blood transfusion. "
2. Intrauterine Devices (Intrauterine Device)
12/01/1985 - "Uterine perforation and deep embedding by an intrauterine device (IUD) require exact determination of its location as a necessary step to safe and effective retrieval. "
09/01/2012 - "DESIGN AND DATA COLLECTION METHOD: This retrospective population-based registry study included 68 patients surgically treated for uterine perforation by an intrauterine device (IUD)/intrauterine system (IUS) at clinics in the Helsinki and Uusimaa hospital district. "
04/01/2015 - "Uterine perforation in an adolescent using an intrauterine device with memory function: a case report and review of the published work."
06/01/2013 - "Uterine perforation caused by intrauterine devices: clinical course and treatment."
05/01/2013 - "Eleven cases of uterine perforation after intrauterine device insertion were listed at Tourcoing hospital between 2005 and 2009. "
3. Vacuum Curettage (Vacuum Pump)
03/01/1996 - "Dilatation and suction curettage was the first-line treatment; uterine perforation developed in two patients (0.6%). "
02/01/1985 - "This study analyzed the 37 cases of uterine perforation that occurred in a series of 9344 1st-trimester vacuum aspiration abortions performed at a hospital in New Delhi, in 1972-81. "
11/01/1995 - "Presented is the case of a 30-year-old US woman who sustained uterine perforation during vacuum aspiration abortion that was not detected until over two weeks after the procedure. "
12/01/1989 - "Uterine perforation is a rare complication of suction curettage. "
12/01/1989 - "Transabdominal and transvaginal ultrasonography of uterine perforation following suction curettage."
4. Hysterectomy
01/01/2014 - "Uterine manipulator may cause uterine perforation and bowel penetration at the beginning of the hysterectomy procedure. "
11/01/2004 - "There were a few minor complications but no uterine perforation or emergency hysterectomies in the group studied."
01/01/2002 - "Hysterectomy was performed in the 3 failed and uterine perforation was revealed by laprotomy. "
10/01/2001 - "Eleven cases of uterine perforation were treated by conservativetherapy, laparoscopy or hysterectomy. "
01/01/1975 - " Hysterectomy was performed for uterine perforation, and the colonic perforation was walled off from the peritoneal cavity. "
5. Contraception (Birth Control)
09/01/2012 - "Intrauterine contraception: incidence and factors associated with uterine perforation--a population-based study."
12/19/1983 - "[Uterine perforation in contraception with an IUD]."
10/02/1978 - "[Intrauterine contraception (IUD) and uterine perforation]."
08/01/2011 - "The potential migration of an IUD and resultant uterine perforation must be considered in the differential diagnosis of any woman using this type of contraception who presents with abdominal pain. "
03/01/2010 - "Intrauterine device (IUD), a conventional method of contraception is rarely associated with uterine perforation and extra uterine dislocation. "