Detrusor after-contraction on ambulatory urodynamics in symptomatic women
Lookup NU author(s): James Coates, Rob Pickard, Dr Michael DrinnanORCiD, Professor Christopher HardingORCiD
ObjectivesTo investigate the association between detrusor after-contraction and urodynamic parameters in a cohort of patients undergoing urodynamic studies by ambulatory monitoring.MethodsAll symptomatic adult female patients with non-neurogenic lower urinary tract dysfunction having ambulatory monitoring over the period January 1998 to January 2014 were included. Urodynamic traces were reviewed to identify detrusor after-contraction. Measured urodynamic variables were Q(max) (mL/s), V-void (mL) and P-det.Qmax (cmH(2)O). Student's unpaired t-test was used to compare the mean of the variable in the detrusor after-contraction and non-detrusor after-contraction groups.ResultsWe identified 331 women with a median age of 50years (range 16-82). Detrusor after-contraction was seen after at least one void in 122 patients giving a prevalence of 37%. A total of 167 (51%) patients had detrusor overactivity. Diagnosis of detrusor overactivity was associated with the presence of detrusor after-contraction (P<0.05). Overall, patients with detrusor after-contraction had a statistically higher mean P-det.Qmax (32 vs 28cmH(2)O, P=0.04) and lower mean voided volume (300 vs 378mL, P<0.001).ConclusionThese findings suggest a relatively high prevalence of detrusor after-contraction during ambulatory monitoring, and an association between detrusor overactivity, V-void, P-det.Qmax and detrusor after-contraction recorded during ambulatory monitoring. Therefore, a link between detrusor after-contractions and the syndrome of overactive bladder can be postulated.
Author(s): Veeratterapillay R, Coates J, Leonard A, Pickard R, Drinnan M, Harding C
Journal: International Journal of Urology
Publisher: Wiley-Blackwell
URL: http://dx.doi.org/10.1111/iju.12887
DOI: 10.1111/iju.12887