Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease
Peter S. Spencer, C. Edwin Garner, Valerie S. Palmer, Glen E. Kisby
Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) is a prototypical neurodegenerative disease with a dominant or exclusive environmental etiology that is acquired early in life and expressed clinically decades later. Although the precise cause of this tauopathy is unknown, much evidence points to the traditional use of cycad seed (. Cycas spp.) for medicine and/or food, cultural practices that have declined coincident with the changing clinical face and gradual disappearance of high-incidence ALS-PDC foci on Guam, Japan (Honshu Island), and New Guinea (West Papua, Indonesia). Two neurotoxic agents in cycad seed occupy current research attention: (1) the genotoxin methylazoxymethanol (MAM, aglycone of the principal cycad toxin, cycasin), which can dramatically disrupt brain development in rodents, and (2) β-. N-methylamino-. l-alanine (. l-BMAA), a minor cycad component and globally widespread cyanobacterial product with neurotoxic properties. Solving the etiology and pathogenesis of ALS-PDC should support the identification of environmental risk factors for neuropathologically related diseases, including sporadic ALS and Alzheimer's disease.
Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders
https://doi.org/10.1016/B978-0-12-800228-5.00011-X
Alzheimer's disease (AD)
Azoxyglycosides
Methylazoxymethanol (MAM)
Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC)
β-N-methylamino-l-alanine (BMAA)
10.1016/B978-0-12-800228-5.00011-X
Dive into the research topics of 'Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease'. Together they form a unique fingerprint.
Indonesia Medicine & Life Sciences 100%
Neurotoxins Medicine & Life Sciences 96%
Seeds Medicine & Life Sciences 86%
Cycasin Medicine & Life Sciences 82%
Cycas Medicine & Life Sciences 77%
Neurodegenerative Diseases Medicine & Life Sciences 73%
methylazoxymethanol Medicine & Life Sciences 73%
Guam Medicine & Life Sciences 68%
Spencer, P. S., Garner, C. E., Palmer, V. S., & Kisby, G. E. (2015). Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease. In Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders (pp. 211-252). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800228-5.00011-X
Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease. / Spencer, Peter S.; Garner, C. Edwin; Palmer, Valerie S. et al.
Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Elsevier Inc., 2015. p. 211-252.
Spencer, PS, Garner, CE, Palmer, VS & Kisby, GE 2015, Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease. in Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Elsevier Inc., pp. 211-252. https://doi.org/10.1016/B978-0-12-800228-5.00011-X
Spencer PS, Garner CE, Palmer VS, Kisby GE. Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease. In Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Elsevier Inc. 2015. p. 211-252 doi: 10.1016/B978-0-12-800228-5.00011-X
Spencer, Peter S. ; Garner, C. Edwin ; Palmer, Valerie S. et al. / Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Elsevier Inc., 2015. pp. 211-252
@inbook{1bf7fd33687d436caf6cc3bd1990aabf,
title = "Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease",
abstract = "Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) is a prototypical neurodegenerative disease with a dominant or exclusive environmental etiology that is acquired early in life and expressed clinically decades later. Although the precise cause of this tauopathy is unknown, much evidence points to the traditional use of cycad seed (. Cycas spp.) for medicine and/or food, cultural practices that have declined coincident with the changing clinical face and gradual disappearance of high-incidence ALS-PDC foci on Guam, Japan (Honshu Island), and New Guinea (West Papua, Indonesia). Two neurotoxic agents in cycad seed occupy current research attention: (1) the genotoxin methylazoxymethanol (MAM, aglycone of the principal cycad toxin, cycasin), which can dramatically disrupt brain development in rodents, and (2) β-. N-methylamino-. l-alanine (. l-BMAA), a minor cycad component and globally widespread cyanobacterial product with neurotoxic properties. Solving the etiology and pathogenesis of ALS-PDC should support the identification of environmental risk factors for neuropathologically related diseases, including sporadic ALS and Alzheimer's disease.",
keywords = "Alzheimer's disease (AD), Azoxyglycosides, Cycads, Methylazoxymethanol (MAM), Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC), β-N-methylamino-l-alanine (BMAA)",
author = "Spencer, {Peter S.} and Garner, {C. Edwin} and Palmer, {Valerie S.} and Kisby, {Glen E.}",
note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
doi = "10.1016/B978-0-12-800228-5.00011-X",
booktitle = "Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders",
T1 - Environmental Neurotoxins Linked to a Prototypical Neurodegenerative Disease
AU - Spencer, Peter S.
AU - Garner, C. Edwin
AU - Palmer, Valerie S.
AU - Kisby, Glen E.
N1 - Publisher Copyright: © 2015 Elsevier Inc. All rights reserved.
N2 - Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) is a prototypical neurodegenerative disease with a dominant or exclusive environmental etiology that is acquired early in life and expressed clinically decades later. Although the precise cause of this tauopathy is unknown, much evidence points to the traditional use of cycad seed (. Cycas spp.) for medicine and/or food, cultural practices that have declined coincident with the changing clinical face and gradual disappearance of high-incidence ALS-PDC foci on Guam, Japan (Honshu Island), and New Guinea (West Papua, Indonesia). Two neurotoxic agents in cycad seed occupy current research attention: (1) the genotoxin methylazoxymethanol (MAM, aglycone of the principal cycad toxin, cycasin), which can dramatically disrupt brain development in rodents, and (2) β-. N-methylamino-. l-alanine (. l-BMAA), a minor cycad component and globally widespread cyanobacterial product with neurotoxic properties. Solving the etiology and pathogenesis of ALS-PDC should support the identification of environmental risk factors for neuropathologically related diseases, including sporadic ALS and Alzheimer's disease.
AB - Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS/PDC) is a prototypical neurodegenerative disease with a dominant or exclusive environmental etiology that is acquired early in life and expressed clinically decades later. Although the precise cause of this tauopathy is unknown, much evidence points to the traditional use of cycad seed (. Cycas spp.) for medicine and/or food, cultural practices that have declined coincident with the changing clinical face and gradual disappearance of high-incidence ALS-PDC foci on Guam, Japan (Honshu Island), and New Guinea (West Papua, Indonesia). Two neurotoxic agents in cycad seed occupy current research attention: (1) the genotoxin methylazoxymethanol (MAM, aglycone of the principal cycad toxin, cycasin), which can dramatically disrupt brain development in rodents, and (2) β-. N-methylamino-. l-alanine (. l-BMAA), a minor cycad component and globally widespread cyanobacterial product with neurotoxic properties. Solving the etiology and pathogenesis of ALS-PDC should support the identification of environmental risk factors for neuropathologically related diseases, including sporadic ALS and Alzheimer's disease.
KW - Alzheimer's disease (AD)
KW - Azoxyglycosides
KW - Cycads
KW - Methylazoxymethanol (MAM)
KW - Western Pacific amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC)
KW - β-N-methylamino-l-alanine (BMAA)
U2 - 10.1016/B978-0-12-800228-5.00011-X
DO - 10.1016/B978-0-12-800228-5.00011-X
BT - Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders