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From the American Academy of Pediatrics| November 01 2007
Management of Children With Autism Spectrum Disorders
Scott M. Myers, MD;
Scott M. Myers, MD
Chris Plauché Johnson, MD, MEd;
Chris Plauché Johnson, MD, MEd
the Council on Children With Disabilities
Pediatrics (2007) 120 (5): 1162–1182.
https://doi.org/10.1542/peds.2007-2362
This article has been reaffirmed: AAP Publications Reaffirmed
This article has been reaffirmed: AAP Publications Retired and Reaffirmed
This article has been reaffirmed: AAP Publications Reaffirmed or Retired
Scott M. Myers, Chris Plauché Johnson, the Council on Children With Disabilities; Management of Children With Autism Spectrum Disorders. Pediatrics November 2007; 120 (5): 1162–1182. 10.1542/peds.2007-2362
Pediatricians have an important role not only in early recognition and evaluation of autism spectrum disorders but also in chronic management of these disorders. The primary goals of treatment are to maximize the child's ultimate functional independence and quality of life by minimizing the core autism spectrum disorder features, facilitating development and learning, promoting socialization, reducing maladaptive behaviors, and educating and supporting families. To assist pediatricians in educating families and guiding them toward empirically supported interventions for their children, this report reviews the educational strategies and associated therapies that are the primary treatments for children with autism spectrum disorders. Optimization of health care is likely to have a positive effect on habilitative progress, functional outcome, and quality of life; therefore, important issues, such as management of associated medical problems, pharmacologic and nonpharmacologic intervention for challenging behaviors or coexisting mental health conditions, and use of complementary and alternative medical treatments, are also addressed.
The term autism spectrum disorders (ASDs) has been used to include the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)1 diagnostic categories autistic disorder, Asperger disorder, and pervasive developmental disorder–not otherwise specified.2 Recent estimates of the prevalence of ASDs are in the range of 6.5 to 6.6 per 1000, and pediatricians, therefore, are likely to care for children and adolescents with these diagnoses.3–5 In the companion document to this clinical report,2 the American Academy of Pediatrics has summarized pertinent background information on ASDs and emphasized the importance of surveillance and screening as well as other potential physician roles in the diagnostic process. However, the role of the primary health care professional extends beyond recognizing signs of ASDs, referring for diagnostic evaluation, conducting an etiologic investigation, providing genetic counseling, and educating caregivers about ASDs and includes ongoing care and management.
ASDs, similar to other neurodevelopmental disabilities, are generally not "curable," and chronic management is required. Although outcomes are variable and specific behavioral characteristics change over time, most children with ASDs remain within the spectrum as adults and, regardless of their intellectual functioning, continue to experience problems with independent living, employment, social relationships, and mental health.6–8 The primary goals of treatment are to minimize the core features and associated deficits, maximize functional independence and quality of life, and alleviate family distress. Facilitating development and learning, promoting socialization, reducing maladaptive behaviors, and educating and supporting families can help accomplish these goals. Ideally, interventions should help mitigate the core features of ASDs, which include impairment in social reciprocity, deficits in communication, and restricted, repetitive behavioral repertoire.
Educational interventions, including behavioral strategies and habilitative therapies, are the cornerstones of management of ASDs. These interventions address communication, social skills, daily-living skills, play and leisure skills, academic achievement, and maladaptive behaviors.
Optimization of medical care is also likely to have a positive impact on habilitative progress and quality of life. In addition to routine preventive care and treatment of acute illnesses, management of sleep dysfunction, coexisting challenging behaviors or psychiatric conditions, and associated medical problems, such as seizures, may be particularly important. Medications have not been proven to correct the core deficits of ASDs and are not the primary treatment. However, associated maladaptive behaviors or psychiatric comorbidities may interfere with educational progress, socialization, health or safety, and quality of life. These behaviors may be amenable to psychopharmacologic intervention or, in some cases, treatment of underlying medical conditions that are causing or exacerbating the behaviors. Effective medical management may allow a child with an ASD to benefit more optimally from educational interventions.
Education has been defined as the fostering of acquisition of skills and knowledge to assist a child to develop independence and personal responsibility; it encompasses not only academic learning but also socialization, adaptive skills, communication, amelioration of interfering behaviors, and generalization of abilities across multiple environments.9 Physicians and other clinicians are often in a position to guide families to empirically supported practices and help them evaluate the appropriateness of the educational services that are being offered.
Comprehensive Programs for Young Children
In the last 2 decades, research and program development in the area of educational intervention have focused largely on very young children with ASDs because of earlier identification and evidence that early intensive intervention may result in substantially better outcomes.9,10 Model early childhood educational programs for children with ASDs have been described in thorough reviews.9,11,12 These model programs are often categorized as behavior analytic, developmental, or structured teaching on the basis of the primary philosophical orientation. Although the approaches have important differences, they also overlap. For example, contemporary comprehensive behavioral curricula borrow from developmental or cognitive approaches (such as addressing joint attention, reciprocal imitation, symbolic play, and theory of mind and using indirect language stimulation and contingent imitation techniques), and some developmental models (eg, the Denver model) and the structured teaching approach of the Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) program use behavioral techniques to fulfill their curriculum goals.10,13
Although programs may differ in philosophy and relative emphasis on particular strategies, they share many common goals, and there is a growing consensus that important principles and components of effective early childhood intervention for children with ASDs include the following9,10,14–16 :
entry into intervention as soon as an ASD diagnosis is seriously considered rather than deferring until a definitive diagnosis is made;
provision of intensive intervention, with active engagement of the child at least 25 hours per week, 12 months per year, in systematically planned, developmentally appropriate educational activities designed to address identified objectives;
low student-to-teacher ratio to allow sufficient amounts of 1-on-1 time and small-group instruction to meet specific individualized goals;
inclusion of a family component (including parent training as indicated);
promotion of opportunities for interaction with typically developing peers to the extent that these opportunities are helpful in addressing specified educational goals;
ongoing measurement and documentation of the individual child's progress toward educational objectives, resulting in adjustments in programming when indicated;
incorporation of a high degree of structure through elements such as predictable routine, visual activity schedules, and clear physical boundaries to minimize distractions;
implementation of strategies to apply learned skills to new environments and situations (generalization) and to maintain functional use of these skills; and
use of assessment-based curricula that address:
functional, spontaneous communication;
social skills, including joint attention, imitation, reciprocal interaction, initiation, and self-management;
functional adaptive skills that prepare the child for increased responsibility and independence;
reduction of disruptive or maladaptive behavior by using empirically supported strategies, including functional assessment;
cognitive skills, such as symbolic play and perspective taking; and
traditional readiness skills and academic skills as developmentally indicated.
Specific Strategies
A variety of specific methodologies are used in educational programs for children with ASDs. Detailed reviews of intervention strategies to enhance communication,9,17–20 teach social skills,21–24 and reduce interfering maladaptive behaviors21,25,26 have been published in recent years. Brief descriptions of selected methodologies are provided below.
Applied behavior analysis (ABA) is the process of applying interventions that are based on the principles of learning derived from experimental psychology research to systematically change behavior and to demonstrate that the interventions used are responsible for the observable improvement in behavior. ABA methods are used to increase and maintain desirable adaptive behaviors, reduce interfering maladaptive behaviors or narrow the conditions under which they occur, teach new skills, and generalize behaviors to new environments or situations. ABA focuses on the reliable measurement and objective evaluation of observable behavior within relevant settings including the home, school, and community. The effectiveness of ABA-based intervention in ASDs has been well documented through 5 decades of research by using single-subject methodology21,25,27,28 and in controlled studies of comprehensive early intensive behavioral intervention programs in university and community settings.29–40 Children who receive early intensive behavioral treatment have been shown to make substantial, sustained gains in IQ, language, academic performance, and adaptive behavior as well as some measures of social behavior, and their outcomes have been significantly better than those of children in control groups.31–40
Highly structured comprehensive early intervention programs for children with ASDs, such as the Young Autism Project developed by Lovaas35,41 at the University of California Los Angeles, rely heavily on discrete trial training (DTT) methodology, but this is only one of many techniques used within the realm of ABA. DTT methods are useful in establishing learning readiness by teaching foundation skills such as attention, compliance, imitation, and discrimination learning, as well as a variety of other skills. However, DTT has been criticized because of problems with generalization of learned behaviors to spontaneous use in natural environments and because the highly structured teaching environment is not representative of natural adult-child interactions. Traditional ABA techniques have been modified to address these issues. Naturalistic behavioral interventions, such as incidental teaching and natural language paradigm/pivotal response training, may enhance generalization of skills.13
Functional behavior analysis, or functional assessment, is an important aspect of behaviorally based treatment of unwanted behaviors. Most problem behaviors serve an adaptive function of some type and are reinforced by their consequences, such as attainment of (1) adult attention, (2) a desired object, activity, or sensation, or (3) escape from an undesired situation or demand. Functional assessment is a rigorous, empirically based method of gathering information that can be used to maximize the effectiveness and efficiency of behavioral support interventions.42 It includes formulating a clear description of the problem behavior (including frequency and intensity); identifying the antecedents, consequences, and other environmental factors that maintain the behavior; developing hypotheses that specify the motivating function of the behavior; and collecting direct observational data to test the hypothesis. Functional analysis also is useful in identifying antecedents and consequences that are associated with increased frequency of desirable behaviors so that they can be used to evoke new adaptive behaviors.
Structured Teaching
The TEACCH method, developed by Schopler and colleagues,43 emphasizes structure and has come to be called "structured teaching." Important elements of structured teaching include organization of the physical environment, predictable sequence of activities, visual schedules, routines with flexibility, structured work/activity systems, and visually structured activities.43 There is an emphasis on both improving skills of individuals with ASDs and modifying the environment to accommodate their deficits. Several reports have documented progress in children who have received TEACCH services as well as parent satisfaction and improvement in parent teaching skills, but these reports were not from controlled studies of treatment outcomes.44–49 In a controlled trial, Ozonoff and Cathcart50 found that children treated with a TEACCH-based home program for 4 months in addition to their local day treatment programs improved significantly more than children in the control group who received local day treatment services only.
Developmental Models
Developmental models are based on use of developmental theory to organize hypotheses regarding the fundamental nature of ASDs and design approaches to address the deficits. The Denver model, for example, is based largely on remediating key deficits in imitation, emotion sharing, theory of mind, and social perception by using play, interpersonal relationships, and activities to foster symbolic thought and teach the power of communication.12 This program has shifted from a center-based treatment unit to service delivery in homes and inclusive school environments. Several studies have demonstrated improvements in cognitive, motor, play, and social skills beyond what would be expected on the basis of initial developmental rates in children who are treated according to the Denver model, but controlled trials are lacking.51–54
Relationship-focused early intervention models include Greenspan and Wieder's developmental, individual-difference, relationship-based (DIR) model,55 Gutstein and Sheely's relationship-development intervention (RDI),56 and the responsive-teaching (RT) curriculum developed by Mahoney et al.57,58 The DIR approach focuses on (1) "floor-time" play sessions and other strategies that are purported to enhance relationships and emotional and social interactions to facilitate emotional and cognitive growth and development and (2) therapies to remediate "biologically based processing capacities," such as auditory processing and language, motor planning and sequencing, sensory modulation, and visual-spatial processing. Published evidence of the efficacy of the DIR model is limited to an unblinded review of case records (with significant methodologic flaws, including inadequate documentation of the intervention, comparison to a suboptimal control group, and lack of documentation of treatment integrity and how outcomes were assessed by informal procedures55 ) and a descriptive follow-up study of a small subset (8%) of the original group of patients.59 RDI focuses on activities that elicit interactive behaviors with the goal of engaging the child in a social relationship so that he or she discovers the value of positive interpersonal activity and becomes more motivated to learn the skills necessary to sustain these relationships.56 Some reviewers have praised the face validity of this model, which targets the core impairment in social reciprocity. However, the evidence of efficacy of RDI is anecdotal; published empirical scientific research is lacking at this time. One study reported beneficial effects of RT on young children with ASDs or other developmental disabilities.58 Parents were taught to use RT strategies to encourage their children to acquire and use pivotal developmental behaviors (attention, persistence, interest, initiation, cooperation, joint attention, and affect). Children in both groups improved significantly on nonstandardized play-based measures of cognition and communication and standardized parent ratings of socioemotional functioning. Although a control group was lacking and the potential role of concurrent educational services was unclear, the improvements were beyond what the authors expected from maturational factors alone.58
A variety of approaches have been reported to be effective in producing gains in communication skills in children with ASDs.9,17,20 Didactic and naturalistic behavioral methodologies (eg, DTT, verbal behavior, natural language paradigm, pivotal response training, milieu teaching) have been studied most thoroughly, but there is also some empirical support for developmental-pragmatic approaches (eg, Social Communication Emotional Regulation Transactional Support, Denver model, RDI, Hanen model).
People with ASDs have deficits in social communication, and treatment by a speech-language pathologist usually is appropriate. Most children with ASDs can develop useful speech, and chronologic age, lack of typical prerequisite skills, failure to benefit from previous language intervention, and lack of discrepancy between language and IQ scores should not exclude a child from receiving speech-language services.60 However, traditional, low-intensity pull-out service delivery models often are ineffective, and speech-language pathologists are likely to be most effective when they train and work in close collaboration with teachers, support personnel, families, and the child's peers to promote functional communication in natural settings throughout the day.60
The use of augmentative and alternative communication modalities, including gestures, sign language, and picture communication programs, often is effective in enhancing communication.17,20,61 The Picture Exchange Communication System (PECS)62,63 is used widely. The PECS method incorporates ABA and developmental-pragmatic principles, and the child is taught to initiate a picture request and persist with the communication until the partner responds. Some nonverbal people with ASDs may benefit from the use of voice-output communication aids, but published evidence for these aids is scant.20,64 Introduction of augmentative and alternative communication systems to nonverbal children with ASDs does not keep them from learning to talk, and there is some evidence that they may be more stimulated to learn speech if they already understand something about symbolic communication.61,62,65
Social Skills Instruction
There is some objective evidence to support traditional and newer naturalistic behavioral strategies and other approaches to teaching social skills.22–24,66–68 Joint attention training may be especially beneficial in young, preverbal children with ASDs, because joint attention behaviors precede and predict social language development.69,70 A recent randomized, controlled trial demonstrated that joint attention and symbolic play skills can be taught and that these skills generalize to different settings and people.71 Families can facilitate joint attention and other reciprocal social interaction experiences throughout the day in the child's regular activities. Examples of these techniques are described in the American Academy of Pediatrics parent booklet "Understanding Autism Spectrum Disorders."72
A social skills curriculum should target responding to the social overtures of other children and adults, initiating social behavior, minimizing stereotyped perseverative behavior while using a flexible and varied repertoire of responses, and self-managing new and established skills.10 Social skills groups, social stories, visual cueing, social games, video modeling, scripts, peer-mediated techniques, and play and leisure curricula are supported primarily by descriptive and anecdotal literature, but the quantity and quality of research is increasing.10,15,73 A number of social skills curricula and guidelines are available for use in school programs and at home.10,66,74,75
Occupational Therapy and Sensory Integration Therapy
Traditional occupational therapy often is provided to promote development of self-care skills (eg, dressing, manipulating fasteners, using utensils, personal hygiene) and academic skills (eg, cutting with scissors, writing). Occupational therapists also may assist in promoting development of play skills, modifying classroom materials and routines to improve attention and organization, and providing prevocational training. However, research regarding the efficacy of occupational therapy in ASDs is lacking. Sensory integration (SI) therapy often is used alone or as part of a broader program of occupational therapy for children with ASDs. The goal of SI therapy is not to teach specific skills or behaviors but to remediate deficits in neurologic processing and integration of sensory information to allow the child to interact with the environment in a more adaptive fashion. Unusual sensory responses are common in children with ASDs, but there is not good evidence that these symptoms differentiate ASDs from other developmental disorders, and the efficacy of SI therapy has not been demonstrated objectively.76–78 Available studies are plagued by methodologic limitations, but proponents of SI note that higher-quality SI research is forthcoming.79 "Sensory" activities may be helpful as part of an overall program that uses desired sensory experiences to calm the child, reinforce a desired behavior, or help with transitions between activities.
Comparative Efficacy of Educational Interventions for Young Children
All treatments, including educational interventions, should be based on sound theoretical constructs, rigorous methodologies, and empirical studies of efficacy.15 Proponents of behavior analytic approaches have been the most active in using scientific methods to evaluate their work, and most studies of comprehensive treatment programs that meet minimal scientific standards involve treatment of preschoolers using behavioral approaches.16,38 However, there is still a need for additional research, including large controlled studies with randomization and assessment of treatment fidelity. Empirical scientific support for developmental models and other interventions is more limited, and well-controlled systematic studies of efficacy are needed.
Most educational programs available to young children with ASDs are based in their communities, and often, an "eclectic" treatment approach is used, which draws on a combination of methods including applied behavior analytic methods such as DTT; structured teaching procedures; speech-language therapy, with or without picture communication or related augmentative or alternative communication strategies; SI therapy; and typical preschool activities. Three studies that compared intensive ABA programs (25–40 hours/week) to equally intensive eclectic approaches have suggested that ABA programs were significantly more effective.31,32,34 Another study that involved children with ASDs and global developmental delay/mental retardation retrospectively compared a less intensive ABA program (mean: 12 hours) to a comparably intensive eclectic approach and found statistically significant but clinically modest outcomes that favored those in the ABA group.33 Although the groups of children were similar on key dependent measures before treatment began, these studies were limited because of parent-determined rather than random assignment to treatment group. Additional studies to evaluate and compare educational treatment approaches are warranted.
Programs for Older Children and Adolescents
Some model programs provide programming throughout childhood and into adulthood.11 More commonly, the focus of specialized programs is on early childhood, and published research evaluating comprehensive educational programs for older children and adolescents with ASDs is lacking. However, there is empirical support for the use of certain educational strategies, particularly those that are based on ABA, across all age groups to increase and maintain desirable adaptive behaviors, reduce interfering maladaptive behaviors or narrow the conditions under which they occur, teach new skills, and generalize behaviors to new environments or situations.13,21,28
When children with ASDs move beyond preschool and early elementary programs, educational intervention continues to involve assessment of existing skills, formulation of individualized goals and objectives, selection and implementation of appropriate intervention strategies and supports, assessment of progress, and adaptation of teaching strategies as necessary to enable students to acquire target skills. The focus on achieving social communication competence, emotional and behavioral regulation, and functional adaptive skills necessary for independence continues. Educational programs should be individualized to address the specific impairments and needed supports while capitalizing on the child's assets rather than being based on a particular diagnostic label.
Specific goals and objectives and the supports that are required to achieve them are listed in a child's individualized education plan and should be the driving force behind decisions regarding the most appropriate, least restrictive classroom placement. Appropriate settings may range from self-contained special education classrooms to full inclusion in regular classrooms. Often, a mix of specialized and inclusive experience is appropriate. Even highly functioning students with ASDs often require accommodations and other supports such as provision of explicit directions, modification of classroom and homework assignments, organizational supports, access to a computer and word-processing software for writing tasks, and social communication skills training. When a paraprofessional aide is assigned, it is important that there be an infrastructure of expertise and support for the child beyond the immediate presence of the aide.80 The specific duties of the aide should be outlined, the strategies to be used should be defined, and the aide should receive adequate training.
In adolescence, the term "transition" is used to describe the movement from child-centered activities to adult-oriented activities. The major transitions are from the school environment to the workplace and from home to community living. In schools, transition-planning activities may begin at as early as 14 years of age, and by 16 years of age, the individualized education plan should include an individualized transition plan. The emphasis may shift from academic to vocational services and from remediating deficits to fostering abilities. A vocational assessment is often conducted to evaluate the adolescent's interests and strengths and to determine the services and supports needed to promote independence in the workplace and in the community. Comprehensive transition planning involves the student, parents, teachers, the medical home, and representatives from all concerned community agencies. Depending on the individual's cognitive level, social skills, health condition, work habits, and behavioral challenges, preparation for competitive, supported, or sheltered employment is targeted. Regardless of the type of employment, attention to skill development should never stop. Skills necessary for independent living should be taught to the degree possible given the abilities of the person. Sexuality education instruction should be included, and there is a growing body of literature that has addressed the topic.81–83
Children with ASDs have the same basic health care needs as children without disabilities and benefit from the same health-promotion and disease-prevention activities, including immunizations. In addition, they may have unique health care needs that relate to underlying etiologic conditions, such as fragile X syndrome or tuberous sclerosis, or to other conditions, such as epilepsy, that often are associated with ASDs. Those with pica or persistent mouthing of fingers or objects should be monitored for elevated blood lead concentrations, particularly if the history suggests potential for environmental exposure.84 These health care needs are most appropriately met within the context of a medical home.85,86
To deliver appropriate and effective medical care, the history, approach to the patient, physical evaluation, and treatment options must be considered in the context of the patient's ASD.87,88 Familiarizing the patient with the office setting and staff, allowing ample time while talking before touching the patient, allowing the child to manipulate instruments and materials, keeping instructions simple, using visual cues and supports, slowing down the pace, exaggerating social cues, and having family and/or familiar staff available may be helpful in reducing the obstacles to health care provision presented by patients' difficulties with social interaction, communication, and accepting novelty.88 Often, more time is required for outpatient appointments. In a nationally representative sample, it was found that children with ASDs spent twice as much time with the physician per outpatient visit compared with children in control groups.89
Associated Morbidity and Mortality
Health care utilization and costs are substantially higher for children and adolescents with ASDs compared with children without ASDs,89–91 and available data suggest that mortality is increased as well (standardized mortality ratio: 2.4–2.6).92,93 The increased mortality in ASDs is thought to be largely, but not completely, accounted for by the increased mortality associated with mental retardation and epilepsy. Cases of suicide in higher-functioning individuals have been reported.6
The reported prevalence of epilepsy among people with ASDs ranges from 11% to 39%.94 Comorbid severe global developmental delay/mental retardation and motor deficits are associated with a high prevalence of seizures (42%),95 whereas the prevalence of seizures is only 6% to 8% in children with ASDs without severe mental retardation, a motor deficit, an associated etiologic medical disorder, or a positive family history of epilepsy.95,96 The prevalence of epilepsy also was higher in studies that included adolescents and young adults, because the onset of epilepsy in ASDs has 2 peaks: 1 before 5 years of age and another in adolescence.97 Anticonvulsant treatment in children with ASDs is based on the same criteria that are used for other children with epilepsy, including accurate diagnosis of the particular seizure type.98
Epileptiform abnormalities on electroencephalography (EEG) are common in children with ASDs, with reported frequencies ranging from 10% to 72%.99 Some studies have suggested that epileptiform abnormalities on EEG100 and/or epilepsy101 are more common in the subgroup of children with ASDs who have a history of regression, whereas other studies have not demonstrated this association.102,103 Autistic regression with epileptiform abnormalities on EEG has been compared by analogy with Landau-Kleffner syndrome and electrical status epilepticus in sleep, but there are important differences between these conditions, and the treatment implications are unclear.94,104 Whether subclinical seizures have adverse effects on language, cognition, and behavior is debated, and there is no evidence-based recommendation for the treatment of children with ASDs and epileptiform abnormalities on EEG, with or without regression.104 Universal screening of patients with ASDs by EEG in the absence of a clinical indication is not currently supported.2,99 However, because of the increased prevalence of seizures in this population, a high index of clinical suspicion should be maintained, and EEG should be considered when there are clinical spells that might represent seizures.
The relationship between gastrointestinal problems and ASDs is unclear, because most studies have not examined representative groups of children with ASDs compared with appropriate controls.105,106 Surveys published in the gastroenterology literature have stated that gastrointestinal problems, such as chronic constipation or diarrhea, occur in 46% to 85% of children with ASDs.107–109 Lower rates in the range of 17% to 24% have been reported in other population-based studies,110–112 and a nested case-control study in the United Kingdom found that only 9% of children with ASDs and the same percentage of controls had a history of gastrointestinal complaints.113 However, in a recent cross-sectional study that used structured interviews and matched control groups, a lifetime history of gastrointestinal symptoms (including abnormal stool pattern, frequent constipation, frequent vomiting, and frequent abdominal pain) was elicited in 70% of the children with ASDs, compared with 42% of the children with other developmental disabilities (P = .03) and 28% of the children without developmental disabilities (P < .001).114
In children with ASDs undergoing endoscopy, who may or may not be representative of the general population of children with ASDs, high rates of lymphoid nodular hyperplasia and, often, histologically subtle esophagitis, gastritis, duodenitis, and colitis have been described, and preliminary evidence suggests that some immunohistochemical features may be unique to inflammation associated with ASDs.105,115,116 The existing literature does not support routine specialized gastroenterological testing for asymptomatic children with ASDs.105 However, if a child with an ASD presents with symptoms such as chronic or recurrent abdominal pain, vomiting, diarrhea, or constipation, it is reasonable to evaluate the gastrointestinal tract. Occult gastrointestinal discomfort also should be considered in a child who presents with a change in behavior, such as outbursts of aggression or self-injury. Radiographic evidence of constipation has been found to be more common in children with ASDs than in controls with abdominal pain (36% vs 10%),117 and effective management may provide global benefit.
Sleep problems are common in children and adolescents with ASDs at all levels of cognitive functioning.118–122 Sleep problems correlate with family distress and may have significant effects on daytime functioning and quality of life of children with ASDs.123–125 In some cases, there may be an identifiable etiology such as obstructive sleep apnea or gastroesophageal reflux; assessment and treatment are guided by history and physical examination. When there is not an identifiable medical cause, behavioral interventions including sleep-hygiene measures, restriction of daytime sleep, positive bedtime routines, and extinction procedures often are effective.118,126–129
Relatively little empirical information is available regarding pharmacologic management of sleep problems in children with ASDs or other developmental disabilities. Recommendations typically are based on case reports and open-label trials, extrapolation from the adult literature, and expert consensus (Table 1). 128 There is some evidence of abnormality of melatonin regulation in children with ASDs,125,130 and melatonin may be effective for improving sleep onset in children with ASDs as well as children with other developmental disabilities131–134 and otherwise healthy children with sleep/wake disorders.135 A recent open-label study suggested that controlled-release melatonin improved sleep in a group of 25 children with ASDs and that treatment gains were maintained at 1- and 2-year follow-up,136 but randomized, double-blind, placebo-controlled studies are needed. Recently, a child and a young adult with ASDs with significant insomnia were reported to have responded well, with no apparent adverse effects, to open-label treatment with the high-affinity melatonin receptor agonist ramelteon.137 Antihistamines, α2-agonists, benzodiazepines, chloral hydrate, trazodone, and newer nonbenzodiazepine hypnotic agents, such as zolpidem and zaleplon, sometimes are used to treat pediatric insomnia.128 In some cases, other conditions or symptoms, such as epilepsy, depression, anxiety, or aggressive out bursts, warrant pharmacologic treatment, and an agent that also may assist with sleep can be chosen.118
Evaluation of Challenging Behaviors
Problematic emotional reactions and behaviors such as aggression and self-injury are common in children and adolescents with ASDs. In some cases, medical factors may cause or exacerbate maladaptive behaviors, and recognition and treatment of medical conditions may eliminate the need for psychopharmacologic agents. For example, in the case of an acute onset or exacerbation of aggressive or self-injurious behavior, a source of pain or discomfort may be identified and treated.138 Sources of discomfort may include otitis media, otitis externa, pharyngitis, sinusitis, dental abscess, constipation, urinary tract infection, fracture, headache, esophagitis, gastritis, colitis, allergic rhinitis, and others. When behavioral deterioration is temporally related to menstrual cycles in an adolescent female,139 use of an analgesic or oral or injectable contraceptive may be helpful. Obstructive sleep apnea may contribute to behavioral deterioration and may be amenable to weight reduction, tonsillectomy and adenoidectomy, or continuous positive airway pressure.140 Extreme food selectivity has the potential to lead to protein-calorie malnutrition or specific vitamin or mineral deficiencies; however, most studies that evaluated nutritional status in children with ASDs have suggested that despite dietary selectivity, malnutrition is uncommon.105,141 Although the prevalence in children with ASDs is unknown, pica related to iron or zinc deficiency may respond to supplementation with the appropriate mineral. It should be noted that it is not clear how frequently medical factors cause or exacerbate serious maladaptive behaviors in children with ASDs, and the efficacy of these interventions is based on anecdotes, case reports, and conventional clinical practice rather than empirical support from clinical trials.
It is also important to consider environmental factors that may precipitate challenging behaviors. Parents, teachers, or other caregivers may inadvertently reinforce maladaptive behaviors, and in such cases, the most appropriate and effective interventions are behavioral. In some instances, a mismatch between educational or behavioral expectations and cognitive ability of the child is responsible for disruptive behavior (eg, when the diagnosis of mental retardation has not been recognized), and adjustment of expectations is the most appropriate intervention. In both situations, a functional analysis of behavior, completed by a behavior specialist in the settings in which the problems occur, will identify factors in the environment that exacerbate or maintain the problematic behavior. A strategy for intervention through behavioral techniques and environmental manipulations can then be formulated and tested.
Pharmacologic interventions may be considered for maladaptive behaviors such as aggression, self-injurious behavior, repetitive behaviors (eg, perseveration, obsessions, compulsions, and stereotypic movements), sleep disturbance, mood lability, irritability, anxiety, hyperactivity, inattention, destructive behavior, or other disruptive behaviors. After treatable medical causes and modifiable environmental factors have been ruled out, a therapeutic trial of medication may be considered if the behavioral symptoms cause significant impairment in functioning and are suboptimally responsive to behavioral interventions. In some cases, the diagnosis of a comorbid disorder, such as major depression, bipolar disorder, or an anxiety disorder, can be made reasonably and the patient can be treated with medications that are useful for treating these conditions in otherwise typically developing children and adolescents. Modifications of diagnostic criteria may be necessary to account for clinical presentations of psychiatric conditions in individuals with developmental disabilities,142,143 and tools such as behavior checklists144 and structured interviews145 may be helpful. In other cases, clinicians opt to target specific interfering maladaptive behaviors or symptom clusters in the absence of a clear comorbid psychiatric diagnosis (a target-symptom approach).146–151
Recent surveys indicate that approximately 45% of children and adolescents152–154 and up to 75% of adults8,155 with ASDs are treated with psychotropic medication. Greater age, lower adaptive skills and social competence, and higher levels of challenging behavior are associated with the likelihood of medication use.154 The evidence regarding the efficacy of psychopharmacologic interventions in patients with ASDs has been detailed in recent reviews.148,150,151,156 Although most psychotropic medications have been used in children with ASDs, there is currently insufficient literature to establish consensus regarding an evidence-based approach to pharmacologic management. However, in recent years, there has been an increase in publication of randomized, double-blind, placebo-controlled clinical trials to guide clinical practice.
Surveys performed in the United States suggest that selective serotonin-reuptake inhibitors (SSRIs), atypical antipsychotic agents, stimulants, and α2-adrenergic agonist antihypertensive agents are the most commonly prescribed classes of psychotropic medications for children with ASDs.152,153 Double-blind, placebo-controlled trials have demonstrated efficacy of the SSRIs fluoxetine157 and fluvoxamine158,159 in the treatment of repetitive and other maladaptive behaviors in patients with ASDs, and open-label trials of these and other SSRIs have shown improvements in target symptoms, including repetitive behaviors, irritability, depressive symptoms, tantrums, anxiety, aggression, difficulty with transitions, and aspects of social interaction and language.157–161 Potential adverse effects of SSRIs include but are not limited to nausea, drowsiness, sexual dysfunction, constipation, abdominal discomfort, fatigue, headache, dizziness, dry mouth, agitation, behavioral activation, hypomania or mania, apathy, suicidal ideation, and alteration of sleep.
Risperidone has become the first medication with US Food and Drug Administration–approved labeling for the symptomatic treatment of irritability (including aggressive behavior, deliberate self-injury, and temper tantrums) in children and adolescents with ASDs. Two large, multisite, randomized, controlled trials have confirmed the short-term efficacy of risperidone for these severe disruptive behaviors in youth with ASDs,162–165 and 2 open-label studies, each with a double-blind discontinuation component, have suggested long-term benefits and tolerance.166,167 Potential adverse effects include but are not limited to excessive appetite and weight gain, insulin resistance, dyslipidemia, hyperprolactinemia, extrapyramidal symptoms, tardive dyskinesia, neuroleptic malignant syndrome, QTc prolongation, dry mouth, urinary retention, constipation, seizures, hematologic abnormalities, and sedation.
Although early studies of the effects of stimulants yielded negative results, recent double-blind, placebo-controlled trials of methylphenidate have demonstrated improvement in hyperactivity, impulsivity, and inattention in children with ASDs.168–170 Methylphenidate is effective in some children with ASDs, but the response rate is lower than that in children with isolated attention-deficit/hyperactivity disorder, adverse effects are more frequent, and it is unclear whether the results can be generalized to other stimulants.170,171 Potential adverse effects of stimulant medications include but are not limited to appetite reduction, inhibition of growth, delayed sleep onset, jitteriness, exacerbation of tics, abdominal discomfort, increased blood pressure, increased heart rate, irritability, increased anxiety, and repetitive behaviors.
Two small double-blind, placebo-controlled trials have documented modest benefits of clonidine in reducing hyperarousal symptoms including hyperactivity, irritability and outbursts, impulsivity, and repetitive behaviors in children with ASDs.172,173 A prospective open-label trial174 and a retrospective record review175 have suggested that guanfacine was similarly effective in some patients. Potential adverse effects of these centrally acting α2-agonists include but are not limited to drowsiness, sedation, dry mouth, decreased blood pressure, dizziness, constipation, and irritability, and these drugs can be dangerous in overdose. Recently, a retrospective study,176 an open-label trial,177 and a small double-blind, placebo-controlled crossover trial178 suggested that atomoxetine may be effective for attention-deficit/hyperactivity disorder–like symptoms in children and adolescents with ASDs, and additional research is warranted. Appetite suppression, nausea, fatigue, mood swings, suicidal ideation, dizziness, and liver injury are among the potential adverse effects of atomoxetine.
A summary of selected target symptoms, potential psychiatric diagnoses, and medication options is provided in Table 1. Pediatricians and other practitioners should only prescribe medications with which they have sufficient expertise, including knowledge of indications and contraindications, dosing, potential adverse effects, drug-drug interactions, and monitoring requirements. It will be important for future research to address the need for more rigorous evaluation of safety and efficacy of psychotropic agents in children with ASDs; the value of combining behavioral and medical interventions; the practice of polypharmacy; delineation of clinical and biological subgroups of patients who may be responsive to particular treatments; the role of drugs in treating deficits in language and nonlanguage cognition, social interaction, and behavioral rigidity; and the potential to alter the neural substrate during early critical periods to affect brain development and future function. Several multisite trials are underway, and others undoubtedly will be forthcoming.179
Principles to guide the approach to psychopharmacologic management of ASDs in clinical practice have been proposed by several authors in recent years, and an approach is outlined in Table 2. 148–151 When medications are used, potential benefits and adverse effects should be explained, informed consent should be obtained, baseline data regarding behaviors and somatic complaints should be collected, and potential strategies for dealing with treatment failure or partial response should be reviewed. It is important to have some quantifiable means of assessing the efficacy of the medication and to obtain input from a variety of sources, such as parents, teachers, therapists, and aides. Consistent use of validated, treatment-sensitive rating scales and medication adverse-effect scales is desirable. A wide variety of outcome measures have been used in research trials and in clinical practice to measure maladaptive behavior treatment effects.199 Among the most common are the Clinical Global Impression Scale, Aberrant Behavior Checklist, and Nisonger Child Behavior Rating Form.
Complementary and alternative medicine (CAM) is defined by the National Center for Complementary and Alternative Medicine as "a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine."200 The definition of CAM adopted by the Cochrane Collaboration is "a broad domain of healing resources that encompasses all health systems, modalities, and practices and their accompanying theories and beliefs, other than those intrinsic to the politically dominant health systems of a particular society or culture in a given historical period."201 Detailed reviews of CAM as related to developmental disabilities and ASD-specific CAM have been published recently.202–204
Use of CAM is common in children with ASDs.152,205–207 Levy et al206 reported that by the time their clinical population received a formal diagnostic evaluation for a suspected ASD, almost one third of the children already had received a complementary or alternative therapy, and a survey conducted in a predominantly white, middle-to-upper socioeconomic-status private-practice population found that 92% of parents who responded had used CAM therapies for their children with ASDs.205 Another recent parent survey found that 52% of the children with an ASD had been treated with at least 1 CAM therapy, compared with 28% of a group of control children without disabilities.207 Surveys indicate that only 36% to 62% of caregivers who used CAM therapies for their children with ASDs had informed the child's primary care physician,207,208 although more information on CAM is something that families indicate that they want from their child's primary health care professionals.209
It is important that health care professionals understand how to evaluate the evidence used to support all treatments, including CAM, psychopharmacologic, and other interventions. Ideally, the evidence supporting or refuting a treatment should include peer-reviewed studies with appropriately diagnosed, well-defined homogeneous study populations; a randomized, double-blind, placebo-controlled design; an adequate sample size to support the statistical analysis presented; control for confounding factors; and use of appropriate, validated outcome measures. When evaluating the efficacy of studies, it is particularly important to keep in mind confounding factors, such as the placebo effect, and the natural history of the disorder. Participation in a study may alter the way a parent interacts with a child and confound the perceived outcome,210 and improvements are expected with maturation and educational interventions. Only appropriately controlled studies are helpful in proving that an effect is attributable to the intervention being studied.
The practitioner should encourage families to seek additional information when they encounter the following claims or situations211 :
treatments that are based on overly simplified scientific theories;
therapies that are claimed to be effective for multiple different, unrelated conditions or symptoms;
claims that children will respond dramatically and some will be cured;
use of case reports or anecdotal data rather than carefully designed studies to support claims for treatment;
lack of peer-reviewed references or denial of the need for controlled studies; or
treatments that are said to have no potential or reported adverse effects.
To help to describe their proposed rationales and mechanisms, CAM therapies used to treat ASDs have been categorized as "nonbiological" or "biological."204 Examples of nonbiological interventions include treatments such as auditory integration training, behavioral optometry, craniosacral manipulation, dolphin-assisted therapy, music therapy, and facilitated communication. Examples of biological therapies include immunoregulatory interventions (eg, dietary restriction of food allergens or administration of immunoglobulin or antiviral agents), detoxification therapies (eg, chelation), gastrointestinal treatments (eg, digestive enzymes, antifungal agents, probiotics, "yeast-free diet," gluten/casein-free diet, and vancomycin), and dietary supplement regimens that are purported to act by modulating neurotransmission or through immune factors or epigenetic mechanisms (eg, vitamin A, vitamin C, vitamin B6 and magnesium, folic acid, folinic acid, vitamin B12, dimethylglycine and trimethylglycine, carnosine, omega-3 fatty acids, inositol, various minerals, and others).203,204
For most of the aforementioned CAM interventions, there is not enough scientific evidence yet to support or refute their use as treatment for ASDs. However, evaluation of treatments is possible, and a few CAM treatments have been appropriately studied. For example, more than a dozen randomized, double-blind, placebo-controlled trials involving more than 700 patients have demonstrated that secretin (a biological treatment) is not an effective treatment for ASDs.212,213 Evaluation of nonbiological treatments also is feasible. This has been demonstrated in the case of facilitated communication, a technique that uses a trained facilitator to provide physical support to a nonverbal person's hand or arm while that person uses a computer keyboard or other device to spell. Evidence suggests that the communications produced actually originate from the facilitator214,215 and that facilitated communication is not a valid treatment for ASDs.216–218
Because of methodologic flaws, insufficient numbers of patients, or lack of replication, many CAM therapies have been inadequately evaluated; therefore, evidence-based recommendations for their use are not possible. The most recent and most appropriately designed trials have demonstrated no significant benefit of dimethylglycine,219,220 vitamin B6 and magnesium,221,222 or auditory integration training.223–225 Both positive226 and negative227,228 results have been described for small, methodologically flawed studies of intravenous immunoglobulin. A recent double-blind, placebo-controlled trial revealed no statistically significant differences on Aberrant Behavior Checklist subscale scores between small groups of children with ASDs who were given omega-3 fatty acids and those who were given placebo.229 However, the investigators noted a trend toward superiority of omega-3 fatty acids over placebo for hyperactivity, which suggests that further investigation may be warranted.229 The gluten/casein-free diet is based on a hypothesis of abnormal gut permeability and exogenous opiate excess. Although use of the gluten/casein-free diet for children with ASDs is popular, there is little evidence to support or refute this intervention, and reviewers have determined that meaningful conclusions cannot be drawn from the existing literature.230,231 Subsequent to these reviews, a randomized, double-blind pilot study demonstrated no significant benefit.232 Double-blind, placebo-controlled elimination and challenge studies are in progress, and it is anticipated that these studies will provide substantially more useful information regarding the efficacy of the gluten/casein-free diet.204,230 Measurement of urinary peptides has not been proven to be clinically useful as a marker for ASDs or as a tool to determine if dietary restriction is warranted or would be effective.
Many popular interventions, such as chelation of heavy metals, antifungal agents to decrease presumed yeast overgrowth, and antiviral agents to modulate the immune system, have not yet been studied in people with ASDs; their popularity is based on unproven theories and anecdotes or case reports. None of these interventions can be endorsed as treatment for ASDs outside of well-designed and appropriately monitored clinical trials. Some treatments, such as intravenous chelation, may be particularly dangerous and should be discouraged. One child with autism died as a result of chelation with edetate disodium (Na2EDTA) despite the facts that a causal association between mercury and ASDs has not been demonstrated, there is no scientific evidence that chelation is an effective treatment for ASDs, and the effectiveness of chelation therapy to improve nervous system symptoms of chronic mercury toxicity has not been established.233 Unless there is clear evidence of current heavy metal toxicity, chelation by any method is not indicated outside of monitored clinical trials.
In some cases, interesting findings await replication or further investigation. For example, in a double-blind, placebo-controlled trial of vitamin C, improvement was found in total and sensory motor scores on the Ritvo-Freeman Real Life Rating Scale,234 and several small studies have suggested that music therapy had some short-term benefit on communication skills but not on behavior problems of children with ASDs.235 Recently, a group of 20 children with ASDs were compared with children without ASDs and found to have an imbalance of methionine and homocysteine metabolism, which was interpreted to represent impaired capacity for methylation and increased oxidative stress.236 Treatment with trimethylglycine, folinic acid, and methylcobalamin resulted in normalization of laboratory findings. The study did not measure clinical response to the intervention, but anecdotal improvements were noted. Interpretation of these preliminary findings awaits further investigation.
Health care practitioners who diagnose and treat children with ASDs should recognize that many of their patients will use nonstandard therapies. The importance of becoming knowledgeable about CAM therapies, inquiring about current and past CAM use, providing balanced information and advice about treatment options, identifying risks or potential harmful effects, avoiding becoming defensive or dismissing CAM in ways that convey a lack of sensitivity or concern, maintaining open communication, and continuing to work with families even if there is disagreement about treatment choices has been emphasized.237 It also is essential to critically evaluate the scientific merits of specific therapies and share this information with families, educate families about how to evaluate information and recognize pseudoscience, and insist that studies that examine CAM be held to the same scientific and ethical standards as all clinical research.202,238
Parents of children with ASDs will understandably pursue interventions that they believe may present some hope of helping their child, particularly if the therapies are viewed as being unlikely to have any adverse effects. Unfortunately, families are often exposed to unsubstantiated, pseudoscientific theories and related clinical practices that are, at best, ineffective and, at worst, compete with validated treatments or lead to physical, emotional, or financial harm. Time, effort, and financial resources expended on ineffective therapies can create an additional burden on families. Health care professionals can help parents and other caregivers to distinguish empirically validated treatment approaches from treatments that have been proven to be ineffective and those that are unproven and potentially ineffective and/or harmful.
Management should focus not only on the child but also on the family. Although parents once were viewed erroneously as the cause of a child's ASD, it is now recognized that parents play a key role in effective treatment.9 Having a child with an ASD has a substantial effect on a family. Parents and siblings of children with ASDs experience more stress and depression than those of children who are typically developing or even those who have other disabilities.239–243 Supporting the family and ensuring its emotional and physical health is an extremely important aspect of overall management of ASDs.
Physicians and other health care professionals can provide support to parents by educating them about ASDs; providing anticipatory guidance; training and involving them as cotherapists; assisting them in obtaining access to resources; providing emotional support through traditional strategies such as empathetic listening and talking through problems; and assisting them in advocating for their child's or sibling's needs.244 In some cases, referral of parents for counseling or other appropriate mental health services may be required. The need for support is longitudinal, although the specific needs may vary throughout the family life cycle.
One of the chief strategies for helping families raise children with ASDs is helping to provide them with access to needed ongoing supports and additional services during critical periods and/or crises. Natural supports include spouses, extended family members, neighbors, religious institutions, and friends who can help with caregiving and who can provide psychological and emotional support. Informal supports include social networks of other families of children with ASDs and community agencies that provide training, respite, social events, and recreational activities. Formal supports include publicly funded, state-administrated programs such as early intervention, special education, vocational and residential/living services, respite services, Medicaid, in-home and community-based waiver services, Supplemental Security Income benefits, and other financial subsidies. The breadth and depth of services vary, even within the same state or region. Few services exist in many rural areas, and public programs may have long waiting lists.
Sibling support groups offer the opportunity to learn important information and skills while sharing experiences and connecting with other siblings of children with ASDs.244 Although the research on support groups for siblings of children with disabilities is difficult to interpret because of study-design problems and inconsistent outcome effects on sibling adjustment, these groups generally have been evaluated positively by participating siblings and parents,244 and there is some evidence of beneficial effects for siblings of children with ASDs.245
Because each state has organized its services and access mechanisms differently, physicians and families must learn their own state's unique rules to access supports by contacting the state or county offices of the states' Department of Health and Human Services or Mental Health and Mental Retardation or the state developmental disabilities organization. In addition, local parent advocacy organizations, national autism and related developmental disability organizations, early intervention administrators, and school district special education coordinators often are knowledgeable about various programs and their respective eligibility requirements.
ASDs are chronic conditions that affect nearly 1 of every 150 children and require ongoing medical and nonmedical intervention. There is a growing body of evidence that supports the efficacy of certain interventions in ameliorating symptoms and enhancing functioning, but much remains to be learned. In addition to their important roles in identifying ASDs through screening and surveillance, establishing the diagnosis, conducting an etiologic evaluation, and providing genetic counseling after a diagnosis is made,2 pediatricians and other primary health care professionals are in a position to provide important longitudinal medical care and to support and educate families and guide them to empirically supported interventions for their children.
Council on Children With Disabilities Executive Committee, 2006–2007
Paul H. Lipkin, MD, Chairperson
J. Daniel Cartwright, MD
Larry W. Desch, MD
John C. Duby, MD
Ellen Roy Elias, MD
Eric B. Levey, MD
Gregory S. Liptak, MD
Nancy A. Murphy, MD
Ann Henderson Tilton, MD
Donald Lollar, EdD
Michelle Macias, MD
Section on Developmental and Behavioral Pediatrics
Merle McPherson, MD, MPH
Maternal and Child Health Bureau
Donna Gore Olson
Family Voices
Bonnie Strickland, PhD
Stephanie Mucha Skipper, MPH
Jill Ackermann, MS
Mark Del Monte, JD
Thomas D. Challman, MD
Susan L. Hyman, MD
Susan E. Levy, MD
S. Andrew Spooner, MD
Partnership for Policy Implementation
Marshalyn Yeargin-Allsopp, MD
All clinical reports from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.
The guidance in this report does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate.
Guidance for the Clinician in Rendering Pediatric Care
American Psychiatric Association.
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR)
. Washington, DC: American Psychiatric Publishing;
Johnson CP, Myers SM; American Academy of Pediatrics, Council on Children With Disabilities. Identification and evaluation of children with autism spectrum disorders.
Pediatrics.
Fombonne E, Zakarian R, Bennett A, Meng L, McLean-Heywood D. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations.
. Available at: www.pediatrics.org/cgi/content/full/118/1/e139
Dosreis S, Weiner CL, Johnson L, Newschaffer CJ. Autism spectrum disorder screening and management practices among general pediatric providers.
J Dev Behav Pediatr.
27(2 suppl)
Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators; Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders: Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2002.
MMWR Surveill Summ.
Howlin P. Outcomes in autism spectrum disorders. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Handbook of Autism and Pervasive Developmental Disorders
. 3rd ed. Vol II. Hoboken, NJ: John Wiley & Sons;
Howlin P, Goode S, Hutton J, Rutter M. Adult outcome for children with autism.
J Child Psychol Psychiatry.
Seltzer MM, Shattuck P, Abbeduto L, Greenberg JS. Trajectory of development in adolescents and adults with autism.
Ment Retard Dev Disabil Res Rev.
National Research Council, Committee on Educational Interventions for Children with Autism.
Educating Children With Autism
. Lord C, McGee JP, eds. Washington, DC: National Academies Press;
Olley JG. Curriculum and classroom structure. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Handleman JS, Harris SL.
Preschool Education Programs for Children With Autism
. 2nd ed. Austin, TX: Pro-Ed;
Harris SL, Handleman JS, Jennett HK. Models of educational intervention for students with autism: home, center, and school-based programming. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Schreibman L, Ingersoll B. Behavioral interventions to promote learning in individuals with autism. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Dawson G, Osterling J. Early intervention in autism. In: Guralnick MJ, ed.
The Effectiveness of Early Intervention: Second Generation Research
. Baltimore, MD: Brookes;
Mastergeorge AM, Rogers SJ, Corbett BA, et al. Nonmedical interventions for autism spectrum disorders. In: Ozonoff S, Rogers SJ, Hendren RL, eds.
Autism Spectrum Disorders: A Research Review for Practitioners
Rogers SJ. Empirically supported comprehensive treatments for young children with autism.
J Clin Child Psychol.
Goldstein H. Communication intervention for children with autism: a review of treatment efficacy.
J Autism Dev Disord.
Koegel LK. Interventions to facilitate communication in autism.
Marans WD, Rubin E, Laurent A. Addressing social communication skills in individuals with high-functioning autism and Asperger syndrome: critical priorities in educational programming. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Paul R, Sutherland D. Enhancing early language in children with autism spectrum disorders. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Bregman JD, Zager D, Gerdtz J. Behavioral interventions. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
. 3rd ed. Vol II. Hoboken NJ: John Wiley & Sons;
Lorimer PA, Simpson RL, Myles BS, et al. The use of social stories as a preventative behavioral intervention in a home setting with a child with autism.
J Posit Behav Interv.
Taylor BA. Teaching peer social skills to children with autism. In: Maurice C, Green G, Foxx RM, eds.
Making a Difference: Behavioral Intervention for Autism
. Austin, TX: Pro-Ed;
Weiss MJ, Harris SL. Teaching social skills to people with autism.
Behav Modif.
Campbell JM. Efficacy of behavioral interventions for reducing problem behavior in persons with autism: a quantitative synthesis of single-subject research.
Res Dev Disabil.
Horner RH, Carr EG, Strain PS, Todd AW, Reed HK. Problem behavior interventions for young children with autism: a research synthesis.
DeMyer MK, Hingtgen JN, Jackson RK. Infantile autism reviewed: a decade of research.
Schizophr Bull.
Matson JL, Benavidez DA, Compton LS, Paclawskyj T, Baglio C. Behavioral treatment of autistic persons: a review of research from 1980 to the present.
Anderson SR, Avery DL, DiPietro EK, Edwards GL, Christian WP. Intensive home-based intervention with autistic children.
Educ Treat Child.
Birnbrauer JS, Leach DJ. The Murdoch Early Intervention Program after 2 years.
Behav Change.
Cohen H, Amerine-Dickens M, Smith T. Early intensive behavioral treatment: replication of the UCLA model in a community setting.
Eikeseth S, Smith T, Jahr E, Eldevik S. Intensive behavioral treatment at school for 4- to 7-year-old children with autism: a 1-year comparison controlled study.
Eldevik S, Eikeseth S, Jahr E, Smith T. Effects of low-intensity behavioral treatment for children with autism and mental retardation.
Howard JS, Sparkman CR, Cohen HG, Green G, Stanislaw H. A comparison of intensive behavior analytic and eclectic treatments for young children with autism.
Lovaas OI. Behavioral treatment and normal educational and intellectual functioning in young autistic children.
J Consult Clin Psychol.
McEachin JJ, Smith T, Lovaas OI. Long-term outcome for children with autism who received early intensive behavioral treatment.
Am J Ment Retard.
Sallows GO, Graupner TD. Intensive behavioral treatment for children with autism: four-year outcome and predictors.
Smith T. Outcome of early intervention for children with autism.
Clin Psychol Sci Pract.
Smith T, Groen AD, Wynne JW. Randomized trial of intensive early intervention for children with pervasive developmental disorder.
Weiss M. Differential rates of skill acquisition and outcomes of early intensive behavioral intervention for autism.
Behav Interv.
Lovaas OI, ed.
Teaching Individuals With Developmental Delays: Basic Intervention Techniques
O'Neill R, Horner R, Albin R, et al.
Functional Assessment and Program Development for Problem Behavior: A Practical Handbook
. Pacific Grove, CA: Brookes/Cole Publishing;
Mesibov GB, Shea V, Schopler E.
The TEACCH Approach to Autism Spectrum Disorders
. New York, NY: Kluwer Academic/Plenum;
Lord C, Schopler E. The role of age at assessment, developmental level, and test in the stability of intelligence scores in young autistic children.
Marcus LM, Lansing M, Andrews CE, Schopler E. Improvement of teaching effectiveness in parents of autistic children.
J Am Acad Child Psychiatry.
Mesibov GB. Formal and informal measures on the effectiveness or the TEACCH programme.
Autism.
Schopler E, Mesibov GB, Baker A. Evaluation of treatment for autistic children and their parents.
Short AB. Short-term treatment outcome using parents as co-therapists for their own autistic children.
Venter AC, Lord C, Schopler E. A follow-up study of high-functioning autistic children.
Ozonoff S, Cathcart K. Effectiveness of a home program intervention for young children with autism.
Rogers SJ, Herbison JM, Lewis HC, et al. An approach for enhancing the symbolic, communicative, and interpersonal functioning of young children with autism or severe emotional handicaps.
J Div Early Child.
Rogers SJ, DiLalla DL. A comparative study of the effects of a developmentally based instructional model on young children with autism and young children with other disorders of behavior and development.
Top Early Child Spec Educ.
Rogers SJ, Lewis H. An effective day treatment model for young children with pervasive developmental disorders.
J Am Acad Child Adolesc Psychiatry.
Rogers SJ, Lewis HC, Reis K. An effective procedure for training early special education teams to implement a model program.
Greenspan SI, Wieder S. Developmental patterns and outcomes in infants and children with disorders in relating and communicating: a chart review of 200 cases of children with autistic spectrum diagnoses.
J Dev Learn Disord.
Gutstein SE, Sheely RK.
Relationship Development Intervention With Children, Adolescents, and Adults
. New York, NY: Jessica Kingsley;
Mahoney G, McDonald J.
Responsive Teaching: Parent-Mediated Developmental Intervention
. Baltimore, MD: Paul H. Brookes;
Mahoney G, Perales F. Relationship-focused early intervention with children with pervasive developmental disorders and other disabilities: a comparative study.
Wieder S, Greenspan SI. Can children with autism master the core deficits and become empathetic, creative, and reflective? A ten to fifteen year follow-up of a subgroup of children with autism spectrum disorders (ASD) who received a comprehensive developmental, individual-difference, relationship-based (DIR) approach.
American Speech-Language-Hearing Association, Ad Hoc Committee on Autism Spectrum Disorders. Principles for speech-language pathologists in diagnosis, assessment, and treatment of autism spectrum disorders across the life span. Available at: www.asha.org/NR/rdonlyres/D0370FEA-98EF-48EE-A9B6-952913FB131B/0/v3TR_autismLSpan.pdf. Accessed February 22,
Millar DC, Light JC, Schlosser RW. The impact of augmentative and alternative communication intervention on the speech production of individuals with developmental disabilities: a research review.
J Speech Lang Hear Res.
Bondy A, Frost L. The picture exchange communication system.
Focus Autistic Behav.
Semin Speech Lang.
Schepis MM, Reid DH, Behrmann MM, Sutton KA. Increasing communicative interactions of young children with autism using a voice output communication aid and naturalistic teaching.
J Appl Behav Anal.
Layton TL. Language training with autistic children using four different modes of presentation.
J Commun Disord.
Krasny L, Williams BJ, Provencal S, Ozonoff S. Social skills interventions for the autism spectrum: essential ingredients and a model curriculum.
Child Adolesc Psychiatr Clin N Am.
McConnell S. Interventions to facilitate social interaction for young children with autism: review of available research and recommendations for educational intervention and future research.
Rogers SJ. Interventions that facilitate socialization in children with autism.
Bruinsma Y, Koegel RL, Koegel LK. Joint attention and children with autism: a review of the literature.
Whalen C, Schreibman L. Joint attention training for children with autism using behavior modification procedures.
Kasari C, Freeman S, Paparella T. Joint attention and symbolic play in young children with autism: a randomized controlled intervention study.
American Academy of Pediatrics.
Understanding Autism Spectrum Disorders
[pamphlet]. Elk Grove Village, IL: American Academy of Pediatrics;
Reynhout G, Carter M. Social stories for children with disabilities.
Gray C, McAndrew S.
My Social Stories Book
. London, England: Jessica Kingsley;
Taylor BA, Jasper S. Teaching programs to increase peer interaction. In: Maurice C, Green G, Foxx RM, eds.
Baranek GT. Efficacy of sensory and motor interventions for children with autism.
Dawson G, Watling R. Interventions to facilitate auditory, visual, and motor integration in autism: a review of the evidence.
Rogers SJ, Ozonoff S. Annotation: what do we know about sensory dysfunction in autism? A critical review of the empirical evidence.
Schaaf RC, Miller LJ. Occupational therapy using a sensory integrative approach for children with developmental disabilities.
Klin A, Volkmar FR. Treatment and intervention guidelines for individuals with Asperger syndrome. In: Klin A, Volkmar FR, Sparrow SS, eds.
. New York, NY: Guilford Press;
Konstantareas MM, Lunsky YJ. Sociosexual knowledge, experience, attitudes, and interests of individuals with autistic disorder and developmental delay.
Murphy N. Sexuality in children and adolescents with disabilities.
Dev Med Child Neurol.
Murphy NA, Elias ER; American Academy of Pediatrics, Council on Children With Disabilities. Sexuality of children and adolescents with developmental disabilities.
Shannon M, Graef JW. Lead intoxication in children with pervasive developmental disorders.
J Toxicol Clin Toxicol.
American Academy of Pediatrics, Medical Home Initiatives for Children With Special Needs Project Advisory Committee. The medical home.
113(5 suppl)
Cooley WC. Redefining primary pediatric care for children with special health care needs: the primary care medical home.
Curr Opin Pediatr.
La Camera RG, La Camera AC. Routine health care. In: Cohen DJ, Volkmar FR, eds.
. 2nd ed. New York, NY: John Wiley & Sons;
Volkmar FR, Wiesner LA, Westphal A. Healthcare issues for children on the autism spectrum.
Curr Opin Psychiatry.
Liptak GS, Stuart T, Auinger P. Health care utilization and expenditures for children with autism: data from U.S. national samples.
Croen LA, Najjar DV, Ray GT, Lotspeich L, Bernal P. A comparison of health care utilization and costs of children with and without autism spectrum disorders in a large group-model health plan.
. Available at: www.pediatrics.org/cgi/content/full/118/4/e1203
Mandell DS, Cao J, Ittenbach R, Pinto-Martin J. Medicaid expenditures for children with autistic spectrum disorders: 1994 to 1999.
Shavelle RM, Strauss DJ, Pickett J. Causes of death in autism.
Pickett JA, Paculdo DR, Shavelle RM, Strauss DJ. 1998–2002 update on "Causes of Death in Autism.
" J Autism Dev Disord.
Ballaban-Gil K, Tuchman R. Epilepsy and epileptiform EEG: association with autism and language disorders.
Tuchman R, Rapin I, Shinnar S. Autistic and dysphasic children II: epilepsy [published correction appears in Pediatrics. 1992;90:264].
Pavone P, Incorpora G, Fiumara A, Parano E, Trifiletti RR, Ruggieri M. Epilepsy is not a prominent feature of primary autism.
Neuropediatrics.
Volkmar FR, Nelson DS. Seizure disorders in autism.
Sankar E. Initial treatment of epilepsy with antiepileptic drugs: pediatric issues.
Neurology.
63(10 suppl 4)
Kagan-Kushnir T, Roberts SW, Snead OC III. Screening electroencephalograms in autism spectrum disorders: evidence-based guideline.
J Child Neurol.
Tuchman RF, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates.
Hrdlicka M, Komarek V, Propper L, et al. Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism.
Eur Child Adolesc Psychiatry.
Canitano R, Luchetti A, Zappella M. Epilepsy, electroencephalographic abnormalities, and regression in children with autism.
Chez MG, Chang M, Krasne V, Coughlan C, Kominsky M, Schwartz A. Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005.
Epilepsy Behav.
Tuchman R, Rapin I. Epilepsy in autism.
Lancet Neurol.
Erickson CA, Stigler KA, Corkins MR, Posey DJ, Fitzgerald JF, McDougle CJ. Gastrointestinal factors in autistic disorder: a critical review.
Kuddo T, Nelson KB. How common are gastrointestinal disorders in children with autism?
Horvath K, Perman JA. Autism and gastrointestinal symptoms.
Curr Gastroenterol Rep.
Lightdale JR, Siegel B, Heyman MB. Gastrointestinal symptoms in autistic children.
Clin Perspect Gastroenterol.
Melmed RD, Schneider CK, Fabes RA, Philips J, Reichelt K. Metabolic markers and gastrointestinal symptoms in children with autism and related disorders [abstract].
J Pediatr Gastroenterol Nutr.
31(suppl 2)
Fombonne E, Chakrabarti S. No evidence for a new variant of measles-mumps-rubella-induced autism.
. Available at: www.pediatrics.org/cgi/content/full/108/4/e58
Molloy CA, Manning-Courtney P. Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders.
Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population-based study.
BMJ.
Black C, Kaye JA, Jick H. Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database.
Valicenti-McDermott M, McVicar K, Rapin I, Wershil BK, Cohen H, Shinnar S. Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease.
Horvath K, Papadimitriou JC, Rabsztyn A, Drachenberg C, Tildon JT. Gastrointestinal abnormalities in children with autistic disorder.
J Pediatr.
Torrente F, Anthony A, Heuschkel RB, Thomson MA, Ashwood P, Murch SH. Focal-enhanced gastritis in regressive autism with features distinct from Crohn's and Helicobacter pylori gastritis.
Am J Gastroenterol.
Afzal N, Murch S, Thirrupathy K, Berger L, Fagbemi A, Heuschkel R. Constipation with acquired megarectum in children with autism.
Malow BA. Sleep disorders, epilepsy, and autism.
Oyane NM, Bjorvatn B. Sleep disturbances in adolescents and young adults with autism and Asperger syndrome.
Polimeni MA, Richdale AL, Francis AJ. A survey of sleep problems in autism, Asperger's disorder and typically developing children.
J Intellect Disabil Res.
Wiggs L, Stores G. Sleep patterns and sleep disorders in children with autistic spectrum disorders: insights using parent report and actigraphy.
Williams G, Sears LL, Allaed A. Sleep problems in children with autism.
J Sleep Res.
Patzold LM, Richdale AL, Tonge BJ. An investigation into sleep characteristics of children with autism and Asperger's disorder.
J Paediatr Child Health.
Schreck KA, Mulick JA, Smith AF. Sleep problems as possible predictors of intensified symptoms of autism.
Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder.
Biol Psychiatry.
Christodulu KV, Durand VM. Reducing bedtime disturbance and night waking using positive bedtime routines and sleep restriction.
Focus Autism Other Dev Disabl.
Meltzer LJ, Mindell JA. Nonpharmacologic treatments for pediatric sleeplessness.
Pediatr Clin North Am.
Owens JA, Babcock D, Blumer J, et al. The use of pharmacotherapy in the treatment of pediatric insomnia in primary care: rational approaches—a consensus meeting summary.
J Clin Sleep Med.
Weiskop S, Richdale A, Matthews J. Behavioural treatment to reduce sleep problems in children with autism or fragile X syndrome.
Kulman G, Lissoni P, Rovelli F, Roselli MG, Brivio, Sequeri P. Evidence of pineal endocrine hypofunction in autistic children.
Neuro Endocrinol Lett.
Jan JE, Freeman RD. Melatonin therapy for circadian rhythm sleep disorders in children with multiple disabilities: what have we learned in the last decade?
Paavonen EJ, Nieminen-von Wendt T, Vanhala R, Aronen ET, von Wendt L. Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder.
J Child Adolesc Psychopharmacol.
Phillips L, Appleton RE. Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment.
Turk J. Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary.
J Med Genet.
Smits MG, van Stel HF, van der Heijden K, Meijer AM, Coenan AM, Kerkhof GA. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial.
Giannotti F, Cortesi F, Cerquiglini A, Bernabei P. An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism.
Stigler KA, Posey DJ, McDougle CJ. Ramelteon for insomnia in two youths with autistic disorder.
Bosch J, Van Dyke C, Smith SM, Poulton S. Role of medical conditions in the exacerbation of self-injurious behavior: an exploratory study.
Ment Retard.
Lee DO. Menstrually related self-injurious behavior in adolescents with autism.
Malow BA, McGrew SG, Harvey M, et al. Impact of treating sleep apnea in a child with autism spectrum disorder.
Pediatr Neurol.
Bowers L. An audit of referrals of children with autistic spectrum disorder to the dietetic service.
J Hum Nutr Diet.
Perry, DW, Marston GM, Hinder SA. The phenomenology of depressive illness in people with a learning disability and autism.
Syzmanski LS, King B, Goldberg B, et al. Diagnosis of mental disorders in people with mental retardation. In: Reiss S, Aman MG, eds.
Psychotropic Medications and Developmental Disabilities: The International Consensus Handbook
. Columbus, OH: Ohio State University Nisonger Center;
Brereton AV, Tonge BJ, Einfeld SL. Psychopathology in children and adolescents with autism compared to young people with intellectual disability.
Leyfer OT, Folstein SE, Bacalman S, et al. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders.
Bostic JQ, Rho Y. Target-symptom psychopharmacology: between the forest and the trees.
Hollander E, Phillips AT, Yeh CC. Targeted treatments for symptom domains in child and adolescent autism.
Lancet.
Myers SM. The status of pharmacotherapy for autism spectrum disorders.
Expert Opin Pharmacother.
Myers SM, Challman TD. Psychopharmacology: an approach to management in autism and intellectual disabilities. In: Accardo PJ, ed.
Capute & Accardo's Neurodevelopmental Disabilities in Infancy and Childhood: Vol I. Neurodevelopmental Diagnosis and Treatment
. 3rd ed. Baltimore, MD: Paul H. Brookes;
Steingard RJ, Connor DF, Au T. Approaches to psychopharmacology. In: Bauman ML, Kemper TL, eds.
The Neurobiology of Autism
. 2nd ed. Baltimore, MD: Johns Hopkins University Press;
Towbin KE. Strategies for pharmacologic treatment of high functioning autism and Asperger syndrome.
Aman MG, Lam KS, Collier-Crespin A. Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of Ohio.
Langworthy-Lam KS, Aman MG, Van Bourgondien ME. Prevalence and patterns of use of psychoactive medicines in individuals with autism in the autism society of North Carolina.
Witwer A, Lecavalier L. Treatment incidence and patterns in children and adolescents with autism spectrum disorders.
Tsakanikos E, Costello H, Holt G, et al. Psychopathology in adults with autism and intellectual disability.
Posey DJ, McDougle CJ. The pharmacotherapy of target symptoms associated with autistic disorder and other pervasive developmental disorders.
Harv Rev Psychiatry.
Hollander E, Phillips A, Chaplin W, et al. A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism.
Neuropsychopharmacology.
McDougle CJ, Naylor ST, Cohen DJ, Volkmar FR, Heninger GR, Price LH. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder.
Arch Gen Psychiatry.
Sugie Y, Sugie H, Fukuda T, et al. Clinical efficacy of fluvoxamine and functional polymorphism in a serotonin transporter gene on childhood autism.
Moore ML, Eichner SF, Jones JR. Treating functional impairment of autism with selective serotonin-reuptake inhibitors.
Ann Pharmacother.
Posey DJ, Erickson CA, Stigler KA, McDougle CJ. The use of selective serotonin reuptake inhibitors in autism and related disorders.
McCracken JT, McGough J, Shah B, et al. Risperidone in children with autism and serious behavioral problems.
N Engl J Med.
Arnold LE, Vitiello B, McDougle C, et al. Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trials.
McDougle CJ, Scahill L, Aman MG, et al. Risperidone for the core symptom domains of autism: results from the study by the Autism Network of the Research Units on Pediatric Psychopharmacology.
Am J Psychiatry.
Shea S, Turgay A, Carroll A, et al. Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders.
Research Units on Pediatric Psychopharmacology Autism Network. Risperidone treatment of autistic disorder: longer-term benefits and blinded discontinuation after 6 months.
Troost PW, Lahuis BE, Steenuis MP, et al. Long-term effects of risperidone in children with autism spectrum disorders: a placebo discontinuation study.
Quintana H, Birmaher B, Stedge D, et al. Use of methylphenidate in the treatment of children with autistic disorder.
Handen BL, Johnson CR, Lubetsky M. Efficacy of methylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder.
Research Units on Pediatric Psychopharmacology Autism Network. Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity.
Aman MG. Management of hyperactivity and other acting-out problems in autism spectrum disorder.
Semin Pediatr Neurol.
Fankhauser MP, Karumanchi VC, German ML, Yates A, Karumanchi SD. A double-blind, placebo-controlled study of the efficacy of transdermal clonidine in autism.
J Clin Psychiatry.
Jaselskis CA, Cook EH, Fletcher E, Leventhal BL. Clonidine treatment of hyperactive and impulsive children with autistic disorder.
J Clin Psychopharmacol.
Scahill L, Aman MG, McDougle CJ, et al. A prospective open trial of guanfacine in children with pervasive developmental disorders. Research Units on Pediatric Psychopharmacology (RUPP) Autism Network.
Posey DJ, Puntney JI, Sasher TM, Kem DL, McDougle CJ. Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases.
Jou RJ, Handen BL, Hardan AY. Retrospective assessment of atomoxetine in children and adolescents with pervasive developmental disorders.
Posey DJ, Wiegand RE, Wilkerson J, Maynard M, Stigler KA, McDougle CJ. Open-label atomoxetine for attention-deficit/hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders.
Arnold LE, Aman MG, Cook AM, et al. Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial.
Vitiello B. An update on publicly funded multisite trials in pediatric psychopharmacology.
Buchsbaum MS, Hollander E, Haznedar MM, et al. Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: a pilot study.
Int J Neuropsychopharmacol.
Namerow LB, Thomas P, Bostic JQ, Prince J, Monuteaux MC. Use of citalopram in pervasive developmental disorders.
Owley T, Walton L, Salt J, et al. An open-label trial of escitalopram in pervasive developmental disorders.
Hollander E, Soorya L, Wasserman S, Esposito K, Chaplin W, Anagnostou E. Divalproex sodium vs. placebo in the treatment of repetitive behaviours in autism spectrum disorder.
Hollander E, Dolgoff-Kaspar R, Cartwright C, Rawitt R, Novotny S. An open trial of divalproex sodium in autism spectrum disorders.
Rugino TA, Samsock TC. Levetiracetam in autistic children: an open-label study.
Hardan AY, Jou RJ, Handen BL. A retrospective assessment of topiramate in children and adolescents with pervasive developmental disorders.
Connor DF, Ozbayrak KR, Benjamin S, Ma Y, Fletcher KE. A pilot study of nadolol for overt aggression in developmentally delayed individuals.
Ratey JJ, Mikkelsen E, Sorgi P, et al. Autism: the treatment of aggressive behaviors.
Reed MD, Findling RL. Overview of current management of sleep disturbances in children: I—pharmacotherapy.
Curr Ther Res.
63(suppl B)
Mehta UC, Patel I, Castello FV. EEG sedation for children with autism.
Ingrassia A, Turk J. The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders: a case series.
Posey DJ, Guenin KD, Kohn AE, Swiezy NB, McDougle CJ. A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders.
Buitelaar JK, van der Gaag RJ, van der Hoeven J. Buspirone in the management of anxiety and irritability in children with pervasive developmental disorders: results of an open-label study.
Kowatch RA, DelBello MD. Pediatric bipolar disorder: emerging diagnostic and treatment approaches.
Cheng-Shannon J, McGough JJ, Pataki C, McCracken JT. Second-generation antipsychotic medications in children and adolescents.
DeLong R. Children with autistic spectrum disorder and a family history of affective disorder.
Kerbeshian J, Burd L, Fisher W. Lithium carbonate in the treatment of two patients with infantile autism and atypical bipolar symptomatology.
Steingard R, Biederman J. Lithium responsive manic-like symptoms in two individuals with autism and mental retardation.
Aman MG, Novotny S, Samango-Sprouse C, et al. Outcome measures for clinical drug trials in autism.
CNS Spectr.
National Center for Complementary and Alternative Medicine. Expanding horizons of healthcare: five year strategic plan 2001–2005. Washington, DC: US Department of Health and Human Services;
Zollman C, Vickers A. What is complementary medicine?
Challman TD, Voigt RG, Myers SM. Nonstandard therapies in developmental disabilities. In: Accardo PJ, ed.
Gupta VB. Complementary and alternative treatments for autism. In: Gupta VB, ed.
Autistic Spectrum Disorders in Children (Pediatric Habilitation Series Volume 12)
. New York, NY: Marcel Dekker;
Levy SE, Hyman SL. Novel treatments for autistic spectrum disorders.
Harrington JW, Rosen L, Garnecho A, Patrick PA. Parental perceptions and use of complementary and alternative medicine practices for children with autistic spectrum disorders in private practice.
Levy SE, Mandell DS, Merhar S, Ittenbach RF, Pinto-Martin JA. Use of complementary and alternative medicine among children recently diagnosed with autistic spectrum disorder.
Wong HHL, Smith RG. Patterns of complementary and alternative medical therapy use in children diagnosed with autism spectrum disorders.
Sibinga EM, Ottolini MC, Duggan AK, Wilson MH. Parent-pediatrician communication about complementary and alternative medicine use for children.
Clin Pediatr (Phila).
Liptak GS, Orlando M, Yingling JT, et al. Satisfaction with primary health care received by families of children with developmental disabilities.
J Pediatr Health Care.
Sandler A. Placebo effects in developmental disabilities: implications for research and practice.
Nickel R. Controversial therapies for young children with developmental disabilities.
Infants Young Child.
Sturmey P. Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials.
Williams KW, Wray JJ, Wheeler DM. Intravenous secretin for autism spectrum disorder.
Cochrane Database Syst Rev.
):CD003495
Smith MD, Haas PJ, Belcher RG. Facilitated communication: the effects of facilitator knowledge and level of assistance on output.
Cardinal DN, Hanson D, Wakeham J. Investigation of authorship in facilitated communication.
American Academy of Pediatrics, Committee on Children With Disabilities. Auditory integration training and facilitated communication for autism.
Jacobson JW, Mulick JA, Schwartz AA. A history of facilitated communication: science, pseudoscience, and antiscience. Science Working Group on Facilitated Communication.
Am Psychol.
Mostert MP. Facilitated communication since 1995: a review of published studies.
Bolman WM, Richmond JA. A double-blind, placebo controlled pilot trial of low dose dimethylglycine in patients with autistic disorder.
Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M. Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.
Findling RL, Maxwell K, Scotese-Wojtila L, Huang J, Yamashita T, Wiznitzer M. High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study.
Nye C, Brice A. Combined vitamin B6-magnesium treatment in autism spectrum disorder.
Mudford OC, Cross BA, Breen S, et al. Auditory integration training for children with autism: no behavioral benefits detected.
Sinha Y, Silove N, Wheeler D, Williams K. Auditory integration training and other sound therapies for autism spectrum disorders.
Sinha Y, Silove N, Wheeler D, Williams K. Auditory integration training and other sound therapies for autism spectrum disorders: a systematic review.
Arch Dis Child.
Gupta S, Aggarwal S, Heads C. Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic characteristics.
DelGiudice-Asch G, Simon L, Schmeidler J, Cunningham-Rundles C, Hollander E. Brief report: a pilot open clinical trial of intravenous immunoglobulin in childhood autism.
Plioplys AV. Intravenous immunoglobulin treatment of children with autism.
Amminger GP, Berger GE, Schafer MR, Klier C, Friedrich MH, Feucht M. Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study.
Christison GW, Ivany K. Elimination diets in autism spectrum disorders: any wheat amidst the chaff?
Milward C, Ferriter M, Calver S, et al. Gluten- and casein-free diets for autistic spectrum disorder.
Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherill L. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial.
Brown MJ, Willis T, Omalu B, Leiker R. Deaths resulting from hypocalcemia after administration of edetate disodium: 2003–2005.
Dolske MC, Spollen J, McKay S, Lancashire E, Tolbert L. A preliminary trial of ascorbic acid as supplemental therapy for autism.
Prog Neuropsychopharmacol Biol Psychiatry.
Gold C, Wigram T, Elefant C. Music therapy in autistic spectrum disorder.
James SJ, Cutler P, Melnyks S, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Am J Clin Nutr.
American Academy of Pediatrics, Committee on Children With Disabilities. Counseling families who choose complementary and alternative medicine for their child with chronic illness or disability [published correction appears in Pediatrics. 2001;108:507].
Hyman SL, Levy SE. Introduction: novel therapies in developmental disabilities—hope, reason, and evidence.
Bågenholm A, Gillberg C. Psychosocial effects on siblings of children with autism and mental retardation: a population-based study.
J Ment Defic Res.
Bouma R, Schweitzer R. The impact of chronic childhood illness on family stress: a comparison between autism and cystic fibrosis.
J Clin Psychol.
Dumas JE, Wolf LC, Fisman SN, et al. Parenting stress, child behavior problems, and dysphoria in parents of children with autism, Down syndrome, behavior disorders, and normal development.
Exceptionality.
Gold N. Depression and social adjustment in siblings of boys with autism.
Gray DE. Ten years on: a longitudinal study of families of children with autism.
J Intellect Dev Disabil.
Marcus LM, Kunce LJ, Schopler E. Working with families. In: Volkmar FR, Paul R, Klin A, Cohen D, eds.
Smith T, Perry A. A sibling support group for brothers and sisters of children with autism.
J Dev Disabil.
RESOURCE FOR FAMILIES
Autism: Caring for Children With Autism Spectrum Disorders: A Resource Toolkit for Clinicians
. Elk Grove Village, IL: American Academy of Pediatrics;
Copyright © 2007 by the American Academy of Pediatrics
Selected Potential Medication Options for Common Target Symptoms or Coexisting Diagnoses in Children With ASDs
Target Symptom Cluster .
Potential Coexisting Diagnoses .
Selected Medication Considerations .
Selected References .
Repetitive behavior, behavioral rigidity, obsessive-compulsive symptoms Obsessive-compulsive disorder, stereotypic movement disorder SSRIs (fluoxetine,a fluvoxamine,a citalopram, escitalopram, paroxetine, sertraline) McDougle et al,158 ,b Buchsbaum et al,180 ,b Sugie et al,159 ,b Hollander et al,157 ,b Moore et al,160 ,c Namerow et al,181 ,d Owley et al182 ,d
Atypical antipsychotic agents (risperidone,a aripiprazole, olanzapine, quetiapine, ziprasidone) McDougle et al164 ,b
Valproic acida Hollander et al183 ,b
Hyperactivity, impulsivity, inattention Attention-deficit/hyperactivity disorder Stimulants (methylphenidate,a dextroamphetamine, mixed amphetamine salts) Quintana et al,168 ,b Handen et al,169 ,b RUPP Autism Network170 ,b
α2-agonists (clonidine,a guanfacine) Fankhauser et al,172 ,b Jaselskis et al,173 ,b Posey et al,175 ,d Scahill et al (RUPP Autism Network)174 ,d
Atomoxetinea Arnold et al,178 ,b Jou et al,176 ,d Posey et al177 ,d
Atypical antipsychotic agents (risperidone,a aripiprazole, olanzapine,a quetiapine, ziprasidone) McCracken et al,162 ,b Arnold et al,163 ,b Shea et al,165 ,b RUPP Autism Network,166 ,b Troost et al167 ,d
Aggression, explosive outbursts, self-injury Intermittent explosive disorder Atypical antipsychotic agents (risperidone,a aripiprazole, olanzapine, quetiapine, ziprasidone) McCracken et al,162 ,b Arnold et al,163 ,b Shea et al,165 ,b RUPP Autism Network,166 ,b Troost et al167 ,d
α2-agonists (clonidine,a guanfacine) Fankhauser et al,172 ,b Jaselskis et al,173 ,b Posey et al175 ,d
Anticonvulsant mood stabilizers (levetiracetam, topiramate, valproic acid) Hollander et al184 ,d, Rugino and Samsock185 ,d, Hardan et al186 ,d, Myers148 ,c, Myers and Challman149 ,c
SSRIs (fluoxetine,a fluvoxamine,a citalopram, escitalopram, paroxetine, sertraline) McDougle et al,158 ,b Moore et al,160 ,c Namerow et al,181 ,d Owley et al182 ,d
β-blockers (propranolol, nadolol, metoprolol, pindolol) Connor et al,187 ,d Ratey et al,188 ,d Myers and Challman149 ,c
Sleep dysfunction Circadian rhythm sleep disorder, dyssomnia–not otherwise specified Melatonin Giannotti et al,136 ,d Jan and Freeman,131 ,c Phillips and Appleton,133 ,c Turk,134 ,c Owens et al128 ,c
Ramelteon Stigler et al137 ,e
Antihistamines (diphenhydramine, hydroxyzine) Reed and Findling,189 ,c Owens et al128 ,c
α2-agonists (clonidine, guanfacine) Mehta et al,190 ,d Ingrassia and Turk,191 ,d Posey et al,175 ,d Owens et al128 ,c
Mirtazapine Posey et al192 ,d
Anxiety Generalized anxiety disorder, anxiety disorder–not otherwise specified SSRIs (fluoxetine,a fluvoxamine,a citalopram, escitalopram, paroxetine, sertraline) McDougle et al,158 ,b Buchsbaum et al,180 ,b Sugie et al,159 ,b Hollander et al,157 ,b Moore et al,160 ,c Namerow et al,181 ,d Owley et al182 ,d
Buspirone Buitelaar et al193 ,d
Depressive phenotype (marked change from baseline including symptoms such as social withdrawal, irritability, sadness or crying spells, decreased energy, anorexia, weight loss, sleep dysfunction) Major depressive disorder, depressive disorder–not otherwise specified SSRIs (fluoxetine,a fluvoxamine,a citalopram, escitalopram, paroxetine, sertraline) McDougle et al,158 ,b Moore et al,160 ,c Namerow et al,181 ,d Owley et al182 ,d
Bipolar phenotype (behavioral cycling with rages and euphoria, decreased need for sleep, manic-like hyperactivity, irritability, aggression, self-injury, sexual behaviors) Bipolar I disorder, bipolar disorder–not otherwise specified Anticonvulsant mood stabilizers (carbamazepine, gabapentin, lamotrigine, oxcarbazepine, topiramate, valproic acid) Kowatch and DelBello,194 ,c Myers and Challman149 ,c
Atypical antipsychotic agents (risperidone, aripiprazole, olanzapine, quetiapine, ziprasidone) Cheng-Shannon et al,195 ,c Kowatch and DelBello,194 ,c Myers,148 ,c Myers and Challman149 ,c
Lithium DeLong,196 ,e Kerbeshian et al,197 ,e Steingard and Biederman,198 ,e Myers,148 ,c Myers and Challman149 ,c
RUPP indicates Research Units on Pediatric Psychopharmacology.
At least 1 published double-blind, placebo-controlled trial supports use in patients with an ASD.
Double-blind, placebo-controlled trial.
Review article.
Open-label trial or retrospective chart study.
Case report.
Clinical Approach to Psychopharmacologic Management
Identify and assess target behaviors
Parent/caregiver interview
Exacerbating factors/triggers (time, setting/location, demand situations, denials, transitions, etc)
Ameliorating factors and response to behavioral interventions
Time trends (increasing, decreasing, stable)
Degree of interference with functioning
Consider baseline behavior-rating scales and/or baseline performance measures/direct observational data
Include input from school staff and other caregivers
Assess existing and available supports
Behavioral services and supports
Educational program, habilitative therapies
Respite care, family psychosocial supports
Search for medical factors that may be causing or exacerbating target behavior(s)
Consider sources of pain or discomfort (infectious, gastrointestinal, dental, allergic, etc)
Consider other medical causes or contributors (sleep disorders, seizures, menstrual cycle, etc)
Complete any medical tests that may have a bearing on treatment choice
Consider psychotropic medication on the basis of the presence of
Evidence that the target symptoms are interfering substantially with learning/academic progress, socialization, health/safety (of the patient and/or others around him or her), or quality of life
Suboptimal response to available behavioral interventions and environmental modifications
Research evidence that the target behavioral symptoms or coexisting psychiatric diagnoses are amenable to pharmacologic intervention
Choose a medication on the basis of
Likely efficacy for the specific target symptoms
Practical considerations such as formulations available, dosing schedule, cost, and requirement for laboratory or electrocardiographic monitoring
Informed consent (verbal or written) from parent/guardian and, when possible, assent from the patient
Establish plan for monitoring of effects
Identify outcome measures
Discuss time course of expected effects
Arrange follow-up telephone contact, completion of rating scales, reassessment of behavioral data, and visits accordingly
Outline a plan regarding what might be tried next if there is a negative or suboptimal response or to address additional target symptoms
Change to a different medication
Add another medication to augment a partial or suboptimal therapeutic response to the initial medication (same target symptoms)
Add a different medication to address additional target symptoms that remain problematic
Obtain baseline laboratory data if necessary for the drug being prescribed and plan appropriate follow-up monitoring
Explore the reasonable dose range for a single medication for an adequate length of time before changing to or adding a different medication
Monitor for adverse effects systematically
Consider careful withdrawal of the medication after 6–12 mo of therapy to determine whether it is still needed
Adapted from Myers SM. The status of pharmacotherapy for autism spectrum disorders. Expert Opin Pharmacother. 2007;8:1579–1603; and Myers SM, Challman TD. Psychopharmacology: an approach to management in autism and intellectual disabilities. In: Accardo PJ, ed. Capute & Accardo's Neurodevelopmental Disabilities in Infancy and Childhood. 3rd ed. Baltimore, MD: Paul H. Brookes; 2007: In press.
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