Time course of alterations in lung lymph and bronchial blood flows after inhalation injury
S. Abdi, David Herndon, J. McGuire, L. Traber, D. L. Traber
The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633% of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.
Journal of Burn Care and Rehabilitation
https://doi.org/10.1097/00004630-199011000-00005
Lymph
Smoke Inhalation Injury
Lung Injury
Abdi, S., Herndon, D., McGuire, J., Traber, L., & Traber, D. L. (1990). Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. Journal of Burn Care and Rehabilitation, 11(6), 510-515. https://doi.org/10.1097/00004630-199011000-00005
Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. / Abdi, S.; Herndon, David; McGuire, J.; Traber, L.; Traber, D. L.
In: Journal of Burn Care and Rehabilitation, Vol. 11, No. 6, 1990, p. 510-515.
Abdi, S, Herndon, D, McGuire, J, Traber, L & Traber, DL 1990, 'Time course of alterations in lung lymph and bronchial blood flows after inhalation injury', Journal of Burn Care and Rehabilitation, vol. 11, no. 6, pp. 510-515. https://doi.org/10.1097/00004630-199011000-00005
Abdi S, Herndon D, McGuire J, Traber L, Traber DL. Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. Journal of Burn Care and Rehabilitation. 1990;11(6):510-515. https://doi.org/10.1097/00004630-199011000-00005
Abdi, S. ; Herndon, David ; McGuire, J. ; Traber, L. ; Traber, D. L. / Time course of alterations in lung lymph and bronchial blood flows after inhalation injury. In: Journal of Burn Care and Rehabilitation. 1990 ; Vol. 11, No. 6. pp. 510-515.
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title = "Time course of alterations in lung lymph and bronchial blood flows after inhalation injury",
abstract = "The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633{\%} of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.",
author = "S. Abdi and David Herndon and J. McGuire and L. Traber and Traber, {D. L.}",
doi = "10.1097/00004630-199011000-00005",
journal = "Journal of Burn Care and Research",
T1 - Time course of alterations in lung lymph and bronchial blood flows after inhalation injury
AU - Abdi, S.
AU - Herndon, David
AU - McGuire, J.
AU - Traber, L.
AU - Traber, D. L.
N2 - The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633% of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.
AB - The effects of inhalation injury on the pulmonary microvascular fluid flux and bronchial blood flow were examined in a long-term study of sheep (N = 13). They were insufflated with either 48 breaths of cotton smoke (n = 8) or air (n = 5) while they were deeply anesthetized with halothane. After injury, anesthesia was discontinued and the animals were mechanically ventilated throughout the experimental period (24 hours). Bronchial blood flow increased significantly at all time points recorded and reached its peak 20 minutes after the inhalation trauma (11 ± 1 ml/hr to 106 ± 18 ml/hr; p < 0.05). Thereafter, bronchial blood flow decreased to a value that was six to eight times above the baseline measurement for the remainder of the study period. With these changes in blood flow, there was a concomitant increase in lung lymph flow. This variable gradually increased and was 633% of the baseline value (6 ± 1 ml/hr to 44 ± 8 ml/hr) 24 hours after the challenge with smoke. The control animals showed little or no change in cardiopulmonary function during the experimental period. There is no correlation between the increase in bronchial blood flow and lung lymph flow patterns after cotton smoke inhalation injury.
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DO - 10.1097/00004630-199011000-00005
JO - Journal of Burn Care and Research
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10.1097/00004630-199011000-00005