Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations
Stanley H. Appel, Vicki Stockton Appel, S. Scott Stewart, Ronald H. Kerman
Stanley H. Appel Department of Neurology
Neurosciences Research Program
Neurological Institute
We examined the family history and associated disease in 58 patients with amyotrophic lateral sclerosis (ALS), as well as the T-cell phenotypes and functions in 46 consecutive patients with this disorder. A family history of thyroid distribution was present in 19%, and an additional 21% of patients described family members with other possible autoimmune disorders. In 19% of the patients with ALS either past or present thyroid disease was documented. Eleven of 47 additional patients with ALS had significant elevations of microsomal and/or thyroglobulin antibody levels. The T-cell phenotypes and functions were comparable in the ALS and control groups, with the exception of the presence of Ia antigen. In patients with ALS, 11.9% of the T cells were positive for the Ia antigen, while in both a normal control population and a non-ALS neurologic disease population, only 6.4% of T cells have this antigenic determinant. These data support involvement of autoimmune mechanisms in ALS.
Archives of neurology
https://doi.org/10.1001/archneur.1986.00520030026007
Arts and Humanities (miscellaneous)
10.1001/archneur.1986.00520030026007
Dive into the research topics of 'Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations'. Together they form a unique fingerprint.
Amyotrophic Lateral Sclerosis Arts & Humanities 100%
Evaluation Arts & Humanities 33%
Cells Arts & Humanities 29%
Phenotype Arts & Humanities 23%
Family History Arts & Humanities 23%
Population Control Arts & Humanities 15%
Appel, S. H., Stockton Appel, V., Stewart, S. S., & Kerman, R. H. (1986). Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations. Archives of neurology, 43(3), 234-238. https://doi.org/10.1001/archneur.1986.00520030026007
Amyotrophic Lateral Sclerosis : Associated Clinical Disorders and Immunological Evaluations. / Appel, Stanley H.; Stockton Appel, Vicki; Stewart, S. Scott et al.
In: Archives of neurology, Vol. 43, No. 3, 01.01.1986, p. 234-238.
Appel, SH, Stockton Appel, V, Stewart, SS & Kerman, RH 1986, 'Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations', Archives of neurology, vol. 43, no. 3, pp. 234-238. https://doi.org/10.1001/archneur.1986.00520030026007
Appel SH, Stockton Appel V, Stewart SS, Kerman RH. Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations. Archives of neurology. 1986 Jan 1;43(3):234-238. https://doi.org/10.1001/archneur.1986.00520030026007
Appel, Stanley H. ; Stockton Appel, Vicki ; Stewart, S. Scott et al. / Amyotrophic Lateral Sclerosis : Associated Clinical Disorders and Immunological Evaluations. In: Archives of neurology. 1986 ; Vol. 43, No. 3. pp. 234-238.
@article{c9f8c9936eae45b2b76051b5866b9daf,
title = "Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations",
abstract = "We examined the family history and associated disease in 58 patients with amyotrophic lateral sclerosis (ALS), as well as the T-cell phenotypes and functions in 46 consecutive patients with this disorder. A family history of thyroid distribution was present in 19%, and an additional 21% of patients described family members with other possible autoimmune disorders. In 19% of the patients with ALS either past or present thyroid disease was documented. Eleven of 47 additional patients with ALS had significant elevations of microsomal and/or thyroglobulin antibody levels. The T-cell phenotypes and functions were comparable in the ALS and control groups, with the exception of the presence of Ia antigen. In patients with ALS, 11.9% of the T cells were positive for the Ia antigen, while in both a normal control population and a non-ALS neurologic disease population, only 6.4% of T cells have this antigenic determinant. These data support involvement of autoimmune mechanisms in ALS.",
author = "Appel, {Stanley H.} and {Stockton Appel}, Vicki and Stewart, {S. Scott} and Kerman, {Ronald H.}",
doi = "10.1001/archneur.1986.00520030026007",
journal = "Archives of neurology",
publisher = "American Medical Association",
T1 - Amyotrophic Lateral Sclerosis
T2 - Associated Clinical Disorders and Immunological Evaluations
AU - Appel, Stanley H.
AU - Stockton Appel, Vicki
AU - Stewart, S. Scott
AU - Kerman, Ronald H.
N2 - We examined the family history and associated disease in 58 patients with amyotrophic lateral sclerosis (ALS), as well as the T-cell phenotypes and functions in 46 consecutive patients with this disorder. A family history of thyroid distribution was present in 19%, and an additional 21% of patients described family members with other possible autoimmune disorders. In 19% of the patients with ALS either past or present thyroid disease was documented. Eleven of 47 additional patients with ALS had significant elevations of microsomal and/or thyroglobulin antibody levels. The T-cell phenotypes and functions were comparable in the ALS and control groups, with the exception of the presence of Ia antigen. In patients with ALS, 11.9% of the T cells were positive for the Ia antigen, while in both a normal control population and a non-ALS neurologic disease population, only 6.4% of T cells have this antigenic determinant. These data support involvement of autoimmune mechanisms in ALS.
AB - We examined the family history and associated disease in 58 patients with amyotrophic lateral sclerosis (ALS), as well as the T-cell phenotypes and functions in 46 consecutive patients with this disorder. A family history of thyroid distribution was present in 19%, and an additional 21% of patients described family members with other possible autoimmune disorders. In 19% of the patients with ALS either past or present thyroid disease was documented. Eleven of 47 additional patients with ALS had significant elevations of microsomal and/or thyroglobulin antibody levels. The T-cell phenotypes and functions were comparable in the ALS and control groups, with the exception of the presence of Ia antigen. In patients with ALS, 11.9% of the T cells were positive for the Ia antigen, while in both a normal control population and a non-ALS neurologic disease population, only 6.4% of T cells have this antigenic determinant. These data support involvement of autoimmune mechanisms in ALS.
U2 - 10.1001/archneur.1986.00520030026007
DO - 10.1001/archneur.1986.00520030026007
JO - Archives of neurology
JF - Archives of neurology