size_categories:100K<n<1M license:cc-by-4.0 region:us
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license: cc-by-4.0
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- 100K<n<1M
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# Paired SARS-COV-2 heavy/light chain sequences from the Observed Antibody Space database

Human paired heavy/light chain amino acid sequences from the Observed Antibody Space (OAS) database obtained from SARS-COV-2 studies.

https://opig.stats.ox.ac.uk/webapps/oas/

Please include the following citation in your work:

```
 Olsen, TH, Boyles, F, Deane, CM. Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences. Protein Science. 2022; 31: 141–146. https://doi.org/10.1002/pro.4205
```
## Data Preparation
This data was obtained on August 3, 2023 by searching the OAS Paired Sequence database with the following criteria:
- Species = "human"
- Disease = "SARS-COV-2"

This returned 704,652 filtered sequences from 3 studies split across 63 .csv.gz data unit files. These were extracted and filtered for records where both the `complete_vdj_heavy` and `complete_vdj_light` values were "T". Finally, the `sequence_alignment_aa_heavy` and `sequence_alignment_aa_light` fields were extracted into dataset and a 90/10 train/test applied. The resulting data was saved in pyarrow format.