The 16th century Florentine Cosimo de Medici ruled the duchy of this Italian region
The most outstanding figure 
of the 16th century Medici was Cosimo I, who,... [DOC] [TLE] Italian Renaissance - Wikipedia [PAR] The Italian Renaissance was the earliest manifestation of the general European 
Renaissance, a period of great cultural change and achievement that began in 
Italy during the 14th century and lasted until the 16th century, ..... Until the late 
14th century, prior to the Medici, Florence's leading family were the House of 
Albizzi.