In the 1600s Thomas Sydenham pioneered the use of this drug to treat malaria
The 
British physician, Thomas Sydenham introduces quinine-containing Cinchona [DOC] [TLE] Artemisia annua, Artemisinin, ACTs and Malaria Control in Africa ... [PAR] Sep 20, 2010 ... of technical and scientific aspects of malarial drugs is provided by Eastman ..... 
Quinine, a plant-based extract, has been used to treat malaria for centuries.