The 16th century Florentine Cosimo de Medici ruled the duchy of this Italian region
[DOC] [TLE] The Medici Family - Facts & Summary - HISTORY.com [PAR] Beginning in 1434 with the rise to power of Cosimo de' Medici (or Cosimo the 
Elder), ... without a male heir in 1737, ending the family dynasty after almost three 
centuries.