In the mid 1500's Sofonisba Anguissola was a painter at the court of this Spanish king & did his portrait
...... 
mid 1500's Isabel de Portugal attributed to Joos van Cleve (Museu Nacional de 
Arte... [DOC] [TLE] Mannerism and Mannerisms in Painting [PAR] Not the least of the unusual things about this painting is the way the figures are 
arrayed ... matter in these paintings, although perplexing, does have familiar 
overtones.