The 16th century Florentine Cosimo de Medici ruled the duchy of this Italian region
The Medici reigned as 
Grand Dukes of Tuscany, starting with Cosimo I de' Medici in 1569 and... [DOC] [TLE] THE ITALIAN CITY-STATES OF THE RENAISSANCE [PAR] In the fifteenth century, Naples, Milan, and Venice ranked among the five most .... 
is to compare the maps of Italy in the mid-fourteenth and early sixteenth centuries
.