Q:

Can Spider-Man get drunk?

Captain America is shown to not be able to get drunk.
With Spider-Man's body operating at even higher levels than Cap, has he ever been shown to be drunk?

A:

Yes, Peter Parker/Spider-Man has been drunk in the comics, and it got in the way of his vigilanteing heroing.
This happened back in Web of Spider-Man #38(1988).
Peter is at a party and gets drunk, and ends up running off to fight the Hobgoblin.
After he almosts gets some innocents hurt, he pretty much swears off drinking.

