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4RESULTS
| Brachial-ankle PWV was significantly higher among A-positive participants at baseline and follow-up .
| 700 |
4RESULTS
| Femoral-ankle PWV was only higher among A-positive participants at follow-up .
| 701 |
4RESULTS
| Measures of central stiffness and blood pressure were not associated with A status at baseline or follow-up , but central stiffness was associated with a change in A deposition over time .
| 702 |
4RESULTS
| Each standard deviation increase in central stiffness ( carotid-femoral PWV , P = .001 ; heart-femoral PWV , P = .004 ) was linked with increases in A deposition over 2 years .
| 703 |
1CONCLUSIONS
| This study showed that A deposition increases with age in nondemented individuals and that arterial stiffness is strongly associated with the progressive deposition of A in the brain , especially in this age group .
| 704 |
1CONCLUSIONS
| The association between A deposition changes over time and generalized arterial stiffness indicated a relationship between the severity of subclinical vascular disease and progressive cerebral A deposition .
| 705 |
0BACKGROUND
| In a low socioeconomic-status population of Latina women , we evaluated the potential of storytelling ( ST ) as a culturally aligned narrative method to promote colorectal cancer ( CRC ) prevention and screening , compared to a risk tool ( RT ) - based intervention .
| 706 |
2METHODS
| Seventy-eight women were randomized in this pilot study to one of two brief interventions to communicate CRC risk reduction options : ST or an RT. .
| 707 |
2METHODS
| Measures of behavioral intentions relative to CRC prevention and screening were obtained following the intervention .
| 708 |
4RESULTS
| Mean scores for intent to obtain and recommend endoscopy to others were significantly better for participants receiving ST than RT ( P = .038 and P = .011 , respectively ) .
| 709 |
4RESULTS
| All participants expressed intent to increase fruit and vegetable consumption and physical activity in response to interventions .
| 710 |
4RESULTS
| Post-intervention perceptions of cancer risk and fear of CRC were not significantly different for participants receiving ST compared with RT. .
| 711 |
4RESULTS
| Pre - to post-intervention perceptions of risk increased in ST and decreased in RT , while decreases in fear were similar across both intervention groups .
| 712 |
1CONCLUSIONS
| Storytelling may be an effective approach for changing CRC risk-related behavioral intentions among Latinas .
| 713 |
1CONCLUSIONS
| Mediating factors ( such as perceived risk or fear ) often used to predict behavior change may not adequately explain the potential persuasive mechanisms of storytelling .
| 714 |
3OBJECTIVE
| To evaluate enhanced recovery after surgery ( ERAS ) protocol in colorectal surgery .
| 715 |
2METHODS
| From september 2006 to February 2007 , 74 patients with colorectal cancer were randomly assigned to ERAS group and control group .
| 716 |
2METHODS
| The stress index , nutrition and metabolism index , intraoperative index and postoperative index were evaluated .
| 717 |
4RESULTS
| Six patients were excluded , 3 in ERAS group ( 2 cases received hepatectomy concomitantly and 1 case received partial ileum resection ) , and 3 in control group ( 1 case received hepatectomy and 1 case received colorectomy concomitantly , another presented asthma paroxysm ) .
| 718 |
4RESULTS
| So there were 34 cases in ERAS group and 34 cases in control , with no statistical differences in sex , age , BMI index and operation types .
| 719 |
4RESULTS
| Deviation of HOMA-IR index of ERAS was lower than the control ( P > 0.05 ) , the same as plasma cortisol at the 1st day after operation ( P < 0.05 ) , but plasma glucagons in the operation of ERAS group was higher than that of control ( P < 0.05 ) .
| 720 |
4RESULTS
| Plasma glucose 1st day after operation of ERAS group was lower than control ( P < 0.05 ) , while plasma triglyceride intraoperation , at 1st day , 2nd day after operation of ERAS was higher than control ( P < 0.05 ) .
| 721 |
4RESULTS
| Nitrogen negative balance of ERAS group was higher than control at 2nd day after surgery , but is lower intraoperation and at 6th day after operation ( P < 0.05 ) .
| 722 |
4RESULTS
| The time of exhaust gas and stool , time to eat fluidity and semi-fluidity , out-of-bed time and exercise time per-day , residual time and complication rate in ERAS group were better than those of control ( P < 0.05 ) .
| 723 |
4RESULTS
| Post-operative expenses of ERAS was lower than that of control ( P < 0.05 ) .
| 724 |
1CONCLUSIONS
| ERAS can decrease surgical stress , increase functional recovery and reduce complication rate .
| 725 |
3OBJECTIVE
| To demonstrate equivalent efficacy for menopausal symptoms between Aerodiol nasal spray and reference oral estradiol therapy , and to investigate the endometrial safety and tolerability of Aerodiol in the long term .
| 726 |
2METHODS
| The efficacy of Aerodiol 300 microg , once daily , was compared with oral estradiol 2 mg/day in a randomized , double-blind trial .
| 727 |
2METHODS
| A statistical test of noninferiority was performed on the mean absolute Kupperman index ( KI ) obtained after 14 and 23 weeks of the two treatments .
| 728 |
2METHODS
| Long-term safety was assessed in a 1-year open-label study .
| 729 |
2METHODS
| The initial Aerodiol dose was 300 microg/day , and was adjusted if required .
| 730 |
2METHODS
| Endometrial biopsies were obtained at inclusion and at the end of the trial and examined independently by two pathologists .
| 731 |
4RESULTS
| In the equivalence trial , the KI improved similarly in the Aerodiol group ( n = 317 ) and the oral estradiol group ( n = 342 ) .
| 732 |
4RESULTS
| Aerodiol was shown statistically to be at least as effective as oral therapy ( P < 0.001 ) , but the incidences of mastalgia and withdrawal bleeding were significantly lower in the Aerodiol group ( P < 0.01 and P < 0.001 , respectively ) .
| 733 |
4RESULTS
| In the long-term safety trial ( n = 408 ) , the rate of Aerodiol treatment continuation at 12 months was 85 % , and there was no incidence of endometrial hyperplasia or cancer .
| 734 |
4RESULTS
| Aerodiol dose adaptation was performed by 29 % of women .
| 735 |
1CONCLUSIONS
| Aerodiol was shown to have equivalent efficacy to reference oral estradiol therapy , but with better gynaecological acceptability .
| 736 |
1CONCLUSIONS
| The endometrial safety of Aerodiol was confirmed in the long term , and the ability to adjust the dosage easily was of benefit to a substantial proportion of women .
| 737 |
3OBJECTIVE
| To observe the operative technique and clinical effects of hidden tension suture after tibiofibular fracture fixation with absorbable thread .
| 738 |
2METHODS
| From October 2003 to October 2008 , 203 patients ( 220 sides ) with tibiofibular fracture underwent hidden tension suture ( test group , 102 cases of 112 sides ) and the common interrupted suture ( control group , 101 cases of 108 sides ) , including 179 males and 24 females with an median age of 36 years ( 3-75 years ) .
| 739 |
2METHODS
| Fracture was caused by traffic accident in 170 cases , by heavy bruise in 21 cases , and by falling from height in 12 cases .
| 740 |
2METHODS
| There were 186 cases of single-side fracture , and 17 cases of double-side fracture .
| 741 |
2METHODS
| Of them , 127 sides were closed fracture , and 93 sides were open fracture ( including 38 sides of type I , 45 sides of type II , and 10 sides of type IIIA according to Gustilo classification for the open fracture ) .
| 742 |
2METHODS
| The locations were upper tibia in 55 sides , middle tibia in 126 sides , and lower tibia in 39 sides .
| 743 |
2METHODS
| The X-ray films showed that there were transverse fractures in 65 sides , oblique fractures in 53 sides , spiral fractures in 45 sides , and comminuted fractures in 57 sides .
| 744 |
2METHODS
| No blood vessel injury , osteofascial compartment syndrome and pressure syndrome were observed .
| 745 |
2METHODS
| The time from injury to operation was 2 hours to 7 days with an average of 2 days .
| 746 |
2METHODS
| Of 220 sides , 45 sides were fixed by interlocking nails , others by internal steel plate .
| 747 |
4RESULTS
| In control group , healing by first intention was achieved in 70 cases ( 69.3 % ) and healing by secondary intention in 31 cases ( 30.7 % ) ; in test group , healing by first intention was achieved in 93 cases ( 91.2 % ) and healing by secondary intention in 9 cases ( 8.8 % ) ; and showing significant difference ( P < 0.05 ) .
| 748 |
4RESULTS
| All patients were followed up for 6 months to 2 years ( average 9 months ) .
| 749 |
4RESULTS
| No complication occurred in test group , and scar was obvious in the control group .
| 750 |
1CONCLUSIONS
| The hidden tension suture with absorbable thread can be a good alternative for the incision healing after tibiofibular fracture fixation .
| 751 |
1CONCLUSIONS
| It deals with the problems of the incision tension and difficult-to-suture , and is good for the incision healing after operation .
| 752 |
3OBJECTIVE
| To observe the effect of regular yogic practices and self-discipline in reducing body fat and elevated lipids in CAD patients .
| 753 |
2METHODS
| In this study one hundred seventy ( 170 ) subjects , of both sexes having coronary artery disease were randomly selected form Department of Cardiology .
| 754 |
2METHODS
| Subjects were divided in to two groups randomly in yoga group and in non-yoga group , eighty five ( 85 ) in each group .
| 755 |
2METHODS
| Out of these ( 170 subjects ) , one hundred fifty four ( 154 ) completed the study protocol .
| 756 |
2METHODS
| TIME LINE : The yogic intervention consisted of 35-40 min/day , five days in a week till six months in the Department of Physiology CSMMU UP Lucknow .
| 757 |
2METHODS
| Body fat testing and estimation of lipid profile were done of the both groups at zero time and after six months of yogic intervention in yoga group and without yogic intervention in non yoga group .
| 758 |
4RESULTS
| In present study , BMI ( p < 0.04 ) , fat % ( p < 0.0002 ) , fat free mass ( p < 0.04 ) , SBP ( p < 0.002 ) , DBP ( p < 0.009 ) , heart rate ( p < 0.0001 ) , total cholesterol ( p < 0.0001 ) , triglycerides ( p < 0.0001 ) , HDL ( p < 0.0001 ) and low density lipoprotein ( p < 0.04 ) were changed significantly .
| 759 |
1CONCLUSIONS
| Reduction of SBP , DBP , heart rate , body fat % , total cholesterol , triglycerides and LDL after regular yogic practices is beneficial for cardiac and hypertensive patients .
| 760 |
1CONCLUSIONS
| Therefore yogic practices included in this study are helpful for the patients of coronary artery disease .
| 761 |
3OBJECTIVE
| To observe the effect of Chinese medicine therapy for strengthening-Pi and nourishing-Shen ( SPNS ) in preventing lamivudine induced YMDD mutation and its immunological mechanism .
| 762 |
2METHODS
| One hundred and sixty chronic hepatitis B ( CHB ) patients with positive HBeAg were equally assigned to two groups at random : the observation group and the control group .
| 763 |
2METHODS
| Patients in the observation group were treated with lamivudine combined with SPNS , and those in the control group were treated with lamivudine only , with the treatment lasting for 52 weeks in total .
| 764 |
2METHODS
| Changes in indexes , including liver function , HbeAg , HBV-DNA , YMDD variation , CD ( 4 ) , CD ( 4 ) / CD ( 8 ) ratio , interferon-gamma ( IFN-gamma ) , interleukin-4 ( IL-4 ) , blood routine , renal function , as well as any adverse reactions that occurred in patients , were observed at different time points .
| 765 |
4RESULTS
| The ALT , AST recovery rate and HBV-DNA negatively inversing rate at the 24th week , the 36th week and the 52nd week were all higher ( P < 0.05 ) ; meanwhile , the YMDD mutation rate at the 36th week and the 52nd week was lower ( P < 0.05 ) in the observation group than in the control group .
| 766 |
4RESULTS
| The posttreatment levels of CD ( 4 ) , CD ( 4 ) / CD ( 8 ) ratio , IFN-gamma , and IL-4 as well as the pre-post treatment difference of these indexes in the observation group were significantly different from those in the control group ( P < 0.05 ) .
| 767 |
1CONCLUSIONS
| Chinese medicine SPNS therapy can significantly reduce the YMDD variation of HBV , and the mechanism may be related to its regulation of the CD ( 4 ) level , CD ( 4 ) / CD ( 8 ) ratio and Th1/Th2 balance .
| 768 |
0BACKGROUND
| Inhaled anesthetics can alter the arrhythmogenicity of exogenously administered epinephrine .
| 769 |
0BACKGROUND
| Although swine anesthetized with desflurane or isoflurane do not differ in their arrhythmic response to exogenous epinephrine , the relative effect of epinephrine in the presence of these anesthetics in humans is untested .
| 770 |
2METHODS
| The authors compared the arrhythmogenicity of submucosally administered epinephrine in 36 ASA physical status 1 and 2 patients undergoing transsphenoidal resection of pituitary tumors who were randomly assigned to receive 1.0-1 .3 MAC desflurane or isoflurane anesthesia .
| 771 |
2METHODS
| A surgeon , blinded to the administered anesthetic and the concentration of epinephrine , injected 1:50,000 , 1:75,000 , or 1:100,000 ( 20 , 13.3 , or 10 micrograms/ml ) epinephrine in saline of volumes sufficient for surgical need .
| 772 |
2METHODS
| The authors defined a positive response as three or more premature ventricular contractions ( PVCs ) in the 5 min after starting the injection .
| 773 |
4RESULTS
| No patient given either anesthetic developed any PVCs with epinephrine doses less than 7.0 micrograms/kg .
| 774 |
4RESULTS
| Greater doses of epinephrine ( 7.0-13 .0 micrograms/kg ) produced positive responses at equal frequencies in the two anesthetic groups .
| 775 |
1CONCLUSIONS
| The authors concluded that isoflurane and desflurane do not differ in their sensitization of human myocardium to the arrhythmogenic effects of exogenously administered epinephrine .
| 776 |
0BACKGROUND
| Black subjects with a family history of premature coronary heart disease ( CHD ) have a marked excess risk , yet barriers prevent effective risk reduction .
| 777 |
0BACKGROUND
| We tested a community-based multiple risk factor intervention ( community-based care [ CBC ] ) and compared it with `` enhanced '' primary care ( EPC ) to reduce CHD risk in high-risk black families .
| 778 |
4RESULTS
| Black 30 - to 59-year-old siblings of a proband with CHD aged < 60 years were randomized for care of BP > or = 140/90 mm Hg , LDL cholesterol > or = 3.37 mmol/L , or current smoking to EPC ( n = 168 ) or CBC ( n = 196 ) and monitored for 1 year .
| 779 |
4RESULTS
| EPC and CBC were designed to eliminate barriers to care .
| 780 |
4RESULTS
| The CBC group received care by a nurse practitioner and a community health worker in a community setting .
| 781 |
4RESULTS
| The CBC group was 2 times more likely to achieve goal levels of LDL cholesterol and blood pressure compared with the EPC group ( 95 % CI , 1.11 to 4.20 and 1.39 to 3.88 , respectively ) with adjustment for baseline levels of age , sex , education , and baseline use of medications .
| 782 |
4RESULTS
| The CBC group demonstrated a significant reduction in global CHD risk , whereas no reduction was seen in the EPC group ( P < 0.0001 ) .
| 783 |
1CONCLUSIONS
| Eliminating known barriers may not be sufficient to reduce CHD risk in primary care settings .
| 784 |
1CONCLUSIONS
| An alternative community care model that addresses barriers may be a more effective way to ameliorate CHD risk in high-risk black families .
| 785 |
3OBJECTIVE
| This study was undertaken to compare the healing outcome of a short period ( 2 weeks ) of intermaxillary fixation ( IMF ) with conventional ( 4-6 weeks ) IMF in the management of fractures of the mandibular tooth-bearing area .
| 786 |
2METHODS
| This was a randomized controlled study conducted at the Lagos University Teaching Hospital , Lagos , Nigeria , between November 2007 and January 2009 .
| 787 |
2METHODS
| Subjects with minimally displaced mandibular fractures in the tooth-bearing area were randomly allocated into 2 treatment groups : IMF for 2 weeks ( study group ) or IMF for 4 to 6 weeks ( control group ) .
| 788 |
2METHODS
| For the purpose of study analysis , the primary predictor variable was the treatment ( IMF for 2 weeks vs IMF for 4-6 weeks ) .
| 789 |
2METHODS
| Other predictor variables were the age and gender of subjects .
| 790 |
2METHODS
| The primary healing outcome was considered either satisfactory or unsatisfactory .
| 791 |
2METHODS
| The following outcome variables that described the healing process were also compared in the 2 groups : healing time , postoperative infection , paresthesia , and maximal interincisal opening .
| 792 |
2METHODS
| Loss of body weight and oral hygiene status at the end of treatment were compared in the 2 groups .
| 793 |
2METHODS
| A value of P < .05 was considered significant .
| 794 |
4RESULTS
| Satisfactory healing was observed in all cases in both groups .
| 795 |
4RESULTS
| However , satisfactory healing was observed earlier ( 5.4 0.9 weeks ) in the control group than in patients with the short IMF period ( 7.2 0.9 weeks ) ( P < .001 ) .
| 796 |
4RESULTS
| Malocclusion that was amenable to selective grinding was the only complication seen in both groups ( n = 2 in study group and n = 1 in control group ) ( P = .492 ) .
| 797 |
4RESULTS
| Subjects in the control group lost more weight after treatment than those in the study group ( P < .001 ) .
| 798 |
4RESULTS
| The recovery of interincisal mouth opening was also better in the study group than in the control group ( P < .001 ) .
| 799 |