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<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Characteristic</th> <th>Cases (n = 1125)</th> <th>Controls (n = 1197)</th> <th>P-valuea</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Demographic factors</td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Age (years [mean ± SD])</td> <td>47.63 ± 8.00</td> <td>47.20 ± 8.78</td> <td>0.217</td> </tr> <tr> <th>2</th> <td>Education, lower than middle school (%)</td> <td>12.27</td> <td>14.79</td> <td>0.124</td> </tr> <tr> <th>3</th> <td>Major risk factors</td> <td></td> <td></td> <td></td> </tr> <tr> <th>4</th> <td>Breast cancer in first-degree relatives (%)</td> <td>3.38</td> <td>2.26</td> <td>0.101</td> </tr> <tr> <th>5</th> <td>Ever had breast fibroadenoma (%)</td> <td>9.78</td> <td>5.26</td> <td>&lt; 0.001</td> </tr> <tr> <th>6</th> <td>Age at menarche (years [mean ± SD])</td> <td>14.41 ± 1.64</td> <td>14.71 ± 1.73</td> <td>0.004</td> </tr> <tr> <th>7</th> <td>Age at first live birthb (years [mean ± SD])</td> <td>26.82 ± 4.07</td> <td>26.17 ± 3.83</td> <td>&lt; 0.001</td> </tr> <tr> <th>8</th> <td>Age at menopausec (years [mean ± SD])</td> <td>48.17 ± 4.65</td> <td>47.46 ± 4.95</td> <td>0.036</td> </tr> <tr> <th>9</th> <td>Physically active in past 10 years (%)</td> <td>19.40</td> <td>26.00</td> <td>&lt; 0.001</td> </tr> <tr> <th>10</th> <td>Body mass index (mean ± SD)</td> <td>23.54 ± 3.39</td> <td>23.25 ± 3.45</td> <td>0.047</td> </tr> <tr> <th>11</th> <td>Waist-to-hip ratio (mean ± SD)</td> <td>0.81 ± 0.06</td> <td>0.80 ± 0.06</td> <td>0.004</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Stratified variable (by median)</th> <th></th> <th></th> <th>MnSOD</th> <th>genotypes</th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Val/Val</td> <td></td> <td></td> <td>Val/Ala</td> <td></td> <td>Ala/Ala</td> </tr> <tr> <th>1</th> <td></td> <td>na</td> <td>ORb (95% CI)</td> <td>na</td> <td>ORb (95% CI)</td> <td>na</td> <td>ORb (95% CI)</td> </tr> <tr> <th>2</th> <td></td> <td></td> <td>Premenopausal women</td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>3</th> <td>BMI</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>4</th> <td>≤ Median</td> <td>250/275</td> <td>1.0 (ref.)</td> <td>73/99</td> <td>0.9 (0.6–1.2)</td> <td>8/7</td> <td>1.3 (0.5–3.7)</td> </tr> <tr> <th>5</th> <td>&gt; Median</td> <td>300/288</td> <td>1.0 (ref.)</td> <td>106/89</td> <td>1.1 (0.8–1.6)</td> <td>13/5</td> <td>2.5 (0.9–7.0)</td> </tr> <tr> <th>6</th> <td>Years of menstruationc</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>7</th> <td>≤ Median</td> <td>203/286</td> <td>1.0 (ref.)</td> <td>77/91</td> <td>1.2 (0.8–1.7)</td> <td>8/8</td> <td>1.4 (0.5–3.7)</td> </tr> <tr> <th>8</th> <td>&gt; Median</td> <td>347/277</td> <td>1.0 (ref.)</td> <td>102/97</td> <td>0.8 (0.6–1.2)</td> <td>13/4</td> <td>2.6 (0.8–8.0)</td> </tr> <tr> <th>9</th> <td></td> <td></td> <td>Postmenopausal women</td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>10</th> <td>BMI</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>11</th> <td>≤ Median</td> <td>126/156</td> <td>1.0 (ref.)</td> <td>39/52</td> <td>1.0 (0.6–1.6)</td> <td>4/7</td> <td>0.7 (0.2–2.5)</td> </tr> <tr> <th>12</th> <td>&gt; Median</td> <td>152/161</td> <td>1.0 (ref.)</td> <td>46/50</td> <td>1.0 (0.6–1.6)</td> <td>3/4</td> <td>0.8 (0.2–3.7)</td> </tr> <tr> <th>13</th> <td>Years of menstruationc</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>14</th> <td>≤ Median</td> <td>128/172</td> <td>1.0 (ref.)</td> <td>44/54</td> <td>1.1 (0.7–1.8)</td> <td>2/6</td> <td>0.4 (0.1–2.2)</td> </tr> <tr> <th>15</th> <td>&gt; Median</td> <td>150/145</td> <td>1.0 (ref.)</td> <td>41/48</td> <td>0.8 (0.5–1.3)</td> <td>5/5</td> <td>1.0 (0.3–3.5)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Protein</th> <th>Percentage</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>PCNA</td> <td>15.93 ± 4.38</td> </tr> <tr> <th>1</th> <td>hMLH1</td> <td>0.25 ± 1.11</td> </tr> <tr> <th>2</th> <td>in hPMS1</td> <td>0.6 ± 0.99</td> </tr> <tr> <th>3</th> <td>the hPMS2</td> <td>0 ± 0</td> </tr> <tr> <th>4</th> <td>hMSH2</td> <td>72.7 ± 20.33</td> </tr> <tr> <th>5</th> <td>TP53</td> <td>0 ± 0</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Group</th> <th>RNA source</th> <th>Treatment</th> <th>Days after injection</th> <th>No. of animals</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>AN</td> <td>Naive control (absolute negative) BALB/cSCID paw</td> <td>None</td> <td>N/A</td> <td>3</td> </tr> <tr> <th>1</th> <td>PA</td> <td>Normal paw from arthritic BALB/cSCID mouse</td> <td>Cell transfer</td> <td>6</td> <td>3</td> </tr> <tr> <th>2</th> <td>AA</td> <td>Acute arthritic paw of BALB/cSCID mouse</td> <td>Cell transfer</td> <td>6</td> <td>5</td> </tr> <tr> <th>3</th> <td>CA</td> <td>Chronically arthritic paw of BALB/cSCID mouse</td> <td>Cell transfer</td> <td>12–14</td> <td>3</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Mean fluorescence</th> <th>of CXCR3a</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Patient no.</td> <td>In PB cells</td> <td>In SF cells</td> <td>D/sb</td> </tr> <tr> <th>1</th> <td>1</td> <td>35.79</td> <td>55.8</td> <td>36.5</td> </tr> <tr> <th>2</th> <td>2</td> <td>23.02</td> <td>77.13</td> <td>36</td> </tr> <tr> <th>3</th> <td>3</td> <td>20.27</td> <td>48.88</td> <td>22.4</td> </tr> <tr> <th>4</th> <td>4</td> <td>15.84</td> <td>27.75</td> <td>34</td> </tr> <tr> <th>5</th> <td>5</td> <td>16.44</td> <td>20.59</td> <td>20.2</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Course</th> <th>No. of patients</th> <th>Age (years)</th> <th>Disease duration (years)</th> <th>No. of joints with active/ limited range of motion</th> <th>PGI</th> <th>ESR (mm/h)</th> <th>Treatment; n</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Polyarticular</td> <td>12</td> <td>11.5 (4.3–14.3)</td> <td>3.4 (0.5–1.2)</td> <td>5.3 (1–13)/18.3 (1–22)</td> <td>7.8 (5–10)</td> <td>78 (24–137)</td> <td>NSAID, MTX; 8</td> </tr> <tr> <th>1</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>NSAID, CS, MTX; 2</td> </tr> <tr> <th>2</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>NSAID, CS; 1</td> </tr> <tr> <th>3</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>NSAID alone; 1</td> </tr> <tr> <th>4</th> <td>Oligoarticular</td> <td>16</td> <td>7.5 (2.1–15.9)</td> <td>2.4 (0.3–14)</td> <td>1.8 (1–4)/1.9 (1–4)</td> <td>6.9 (5–10)</td> <td>31.5 (5–65)</td> <td>NSAID alone; 11</td> </tr> <tr> <th>5</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>NSAID, MTX; 2</td> </tr> <tr> <th>6</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>Nil; 3</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Patient no.</th> <th>Age (year)</th> <th>Form</th> <th>Pattern</th> <th>CD3</th> <th>CCR7</th> <th></th> <th></th> <th>CXCR3</th> <th></th> <th></th> <th>CCR5</th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td>Lining</td> <td>Sublining</td> <td>Aggregates</td> <td>Lining</td> <td>Sublining</td> <td>Aggregates</td> <td>Lining</td> <td>Sublining</td> <td>Aggregates</td> </tr> <tr> <th>1</th> <td>1</td> <td>14</td> <td>Oligo per.</td> <td>Diffuse</td> <td>+++</td> <td>+</td> <td>+++</td> <td>NP</td> <td>+++</td> <td>+++</td> <td>NP</td> <td>+++</td> <td>++</td> <td>NP</td> </tr> <tr> <th>2</th> <td>2</td> <td>19</td> <td>Poly RF-</td> <td>Diffuse</td> <td>+</td> <td>-</td> <td>++</td> <td>NP</td> <td>+</td> <td>+++</td> <td>NP</td> <td>+</td> <td>-</td> <td>NP</td> </tr> <tr> <th>3</th> <td>3</td> <td>10</td> <td>Oligo per.</td> <td>T-B</td> <td>++</td> <td>-</td> <td>+</td> <td>++</td> <td>+</td> <td>++</td> <td>++</td> <td>++</td> <td>+</td> <td>-</td> </tr> <tr> <th>4</th> <td>4</td> <td>12</td> <td>Oligo ext.</td> <td>T-B</td> <td>+++</td> <td>++</td> <td>+++</td> <td>+++</td> <td>++</td> <td>+++</td> <td>+++</td> <td>++</td> <td>+</td> <td>++</td> </tr> <tr> <th>5</th> <td>5</td> <td>7</td> <td>Poly RF-</td> <td>T-B</td> <td>++</td> <td>-</td> <td>-</td> <td>+</td> <td>++</td> <td>+++</td> <td>+++</td> <td>+++</td> <td>+</td> <td>+</td> </tr> <tr> <th>6</th> <td>6</td> <td>15</td> <td>Poly RF-</td> <td>GC</td> <td>+++</td> <td>-</td> <td>+</td> <td>++</td> <td>+++</td> <td>+++</td> <td>+++</td> <td>+++</td> <td>+</td> <td>-</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th></th> <th></th> <th>100 × CD4+CD25+/CD4+</th> <th>(N)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Treatment</td> <td>Expt no.</td> <td>Organ</td> <td>IFN-γR KO</td> <td>WT</td> </tr> <tr> <th>1</th> <td>Naive</td> <td>1</td> <td>Thymus</td> <td>3.2 ± 0.6 (5)</td> <td>2.2 ± 0.7 (5)</td> </tr> <tr> <th>2</th> <td></td> <td></td> <td>Spleen</td> <td>10.1 ± 0.9 (3) *</td> <td>7.4 ± 0.2 (3)</td> </tr> <tr> <th>3</th> <td></td> <td></td> <td>Lymph nodes</td> <td>6.9 ± 1.1 (5)</td> <td>5.1 ± 1.1 (5)</td> </tr> <tr> <th>4</th> <td></td> <td>2</td> <td>Spleen</td> <td>14.4 (1)</td> <td>9.9 (1)</td> </tr> <tr> <th>5</th> <td></td> <td></td> <td>Lymph nodes</td> <td>9.1 ± 0.9 (4)</td> <td>6.6 ± 0.7 (4)</td> </tr> <tr> <th>6</th> <td></td> <td>3</td> <td>Lymph nodes</td> <td>11.2 (1)</td> <td>7.0 (1)</td> </tr> <tr> <th>7</th> <td>CIA</td> <td>4</td> <td>Thymus</td> <td>3.5 ± 0.9 (3)</td> <td>4.0 ± 1.6 (3)</td> </tr> <tr> <th>8</th> <td></td> <td></td> <td>Spleen</td> <td>11.0 ± 1.3 (2)</td> <td>7.9 ± 0.7 (2)</td> </tr> <tr> <th>9</th> <td></td> <td></td> <td>Lymph nodes</td> <td>10.2 ± 0.8 (6)</td> <td>7.7 ± 0.6 (6)</td> </tr> <tr> <th>10</th> <td></td> <td>5</td> <td>Spleen</td> <td>12.1 ± 2.9 (3)</td> <td>9.2 ± 0.8 (3)</td> </tr> <tr> <th>11</th> <td></td> <td></td> <td>Lymph nodes</td> <td>12.9 ± 1.4 (4)</td> <td>10.3 ± 1.1 (4)</td> </tr> <tr> <th>12</th> <td></td> <td>6</td> <td>Lymph nodes</td> <td>13.4 ± 0.4 (4) *</td> <td>9.2 ± 0.7 (4)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>SAGE library</th> <th>Total testis</th> <th>Adult testis somatic cells</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>TT 1+2</td> <td>ATSC</td> </tr> <tr> <th>1</th> <td>Total tags</td> <td>76 854</td> <td>81 478</td> </tr> <tr> <th>2</th> <td>Unique tags</td> <td>24 529</td> <td>22 809</td> </tr> <tr> <th>3</th> <td>Unique tags with count &gt; 1</td> <td>7 481</td> <td>7 435</td> </tr> <tr> <th>4</th> <td>Proportions of unique tags with count &gt; 1</td> <td></td> <td></td> </tr> <tr> <th>5</th> <td>% of total tags</td> <td>77.8</td> <td>81.1</td> </tr> <tr> <th>6</th> <td>% of unique tags</td> <td>30.5</td> <td>32.6</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Predicted</th> <th>Observed</th> <th>N of observations</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>0.001</td> <td>0.001</td> <td>1116</td> </tr> <tr> <th>1</th> <td>0.010</td> <td>0.007</td> <td>2621</td> </tr> <tr> <th>2</th> <td>0.020</td> <td>0.017</td> <td>2478</td> </tr> <tr> <th>3</th> <td>0.030</td> <td>0.024</td> <td>2309</td> </tr> <tr> <th>4</th> <td>0.040</td> <td>0.033</td> <td>2043</td> </tr> <tr> <th>5</th> <td>0.050</td> <td>0.042</td> <td>1789</td> </tr> <tr> <th>6</th> <td>0.060</td> <td>0.051</td> <td>1450</td> </tr> <tr> <th>7</th> <td>0.070</td> <td>0.062</td> <td>1113</td> </tr> <tr> <th>8</th> <td>0.080</td> <td>0.069</td> <td>835</td> </tr> <tr> <th>9</th> <td>0.090</td> <td>0.076</td> <td>595</td> </tr> <tr> <th>10</th> <td>0.099</td> <td>0.081</td> <td>459</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Level of Evidence</th> <th>Preventive Manoeuvre</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>AΩ &amp; B¥-categories: (Appropriate)</td> <td>1. Folic acid for primary prevention of neural tube defects</td> </tr> <tr> <th>1</th> <td></td> <td>2. Smoking cessation and nicotine replacement</td> </tr> <tr> <th>2</th> <td></td> <td>3. Treatment for Hypertension</td> </tr> <tr> <th>3</th> <td></td> <td>4. Mammography and exam in women over 50</td> </tr> <tr> <th>4</th> <td></td> <td>5. STD screening for high risk groups</td> </tr> <tr> <th>5</th> <td></td> <td>6. Papanicolaou smears for sexually active women</td> </tr> <tr> <th>6</th> <td></td> <td>7. Influenza vaccination to patients 65 and older</td> </tr> <tr> <th>7</th> <td></td> <td>8. Blood pressure measurement for patients 21 to 64 years of age</td> </tr> <tr> <th>8</th> <td>Dψ- category: (Inappropriate)</td> <td>1. Proteinuria screening for general population</td> </tr> <tr> <th>9</th> <td></td> <td>2. Blood glucose for the general population</td> </tr> <tr> <th>10</th> <td></td> <td>3. Prostate-specific antigen testing for men over 50</td> </tr> <tr> <th>11</th> <td></td> <td>4. Chest radiography</td> </tr> <tr> <th>12</th> <td></td> <td>5. Mammography in women under 50</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Measure</th> <th>Intervention Group (N = 22)</th> <th>Control Group (N = 23)</th> <th>Significance (P value)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Percentage of Group Practices</td> <td>77.3%</td> <td>60.9%</td> <td>.34</td> </tr> <tr> <th>1</th> <td>Percentage Teaching Affiliated</td> <td>54.5%</td> <td>52.2%</td> <td>1.00</td> </tr> <tr> <th>2</th> <td>Percentage in communities greater than 50,000</td> <td>86.4%</td> <td>65.2%</td> <td>.17</td> </tr> <tr> <th>3</th> <td>Mean number of physicians in group practices</td> <td>2.91</td> <td>2.70</td> <td>.71</td> </tr> <tr> <th>4</th> <td>Mean number of registered nurses in practices</td> <td>1.16</td> <td>1.64</td> <td>.48</td> </tr> <tr> <th>5</th> <td>Mean year of graduation from medical school</td> <td>1975</td> <td>1975</td> <td>.92</td> </tr> <tr> <th>6</th> <td>Mean proportion of female physicians</td> <td>12.6</td> <td>20.4</td> <td>.37</td> </tr> <tr> <th>7</th> <td>Mean roster size</td> <td>4317</td> <td>3874</td> <td>.55</td> </tr> <tr> <th>8</th> <td>Mean number of patients seen per day</td> <td>34.4</td> <td>33.0</td> <td>.59</td> </tr> <tr> <th>9</th> <td>Percentage of female patients served</td> <td>53.4</td> <td>53.8</td> <td>.89</td> </tr> <tr> <th>10</th> <td>Mean age of patients served</td> <td>46.4</td> <td>46.8</td> <td>.87</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Variable</th> <th>Value and Rangea</th> <th>Source</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>A &amp; B Manœuvres</td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Folic Acid</td> <td></td> <td></td> </tr> <tr> <th>2</th> <td>Difference in no. of eligible patients counseled</td> <td>1495 (854, 2136)</td> <td>(36)</td> </tr> <tr> <th>3</th> <td>Probability of reducing neural tube defects</td> <td>.00058</td> <td>(55)</td> </tr> <tr> <th>4</th> <td>Life-time treatment costs of Spina Bifida</td> <td>$201,822b</td> <td>(51)</td> </tr> <tr> <th>5</th> <td>Smoking Cessation Counselling/NRT</td> <td></td> <td></td> </tr> <tr> <th>6</th> <td>Difference in no. of eligible patients counseled</td> <td>253 (-1072, 1577)</td> <td>(36)</td> </tr> <tr> <th>7</th> <td>Efficacy of NRT</td> <td>.06</td> <td>(3)</td> </tr> <tr> <th>8</th> <td>Incidence of lung cancer in smokers</td> <td>.0024</td> <td>(48)</td> </tr> <tr> <th>9</th> <td>Treatment costs for lung cancer</td> <td>$7,074</td> <td>(56)</td> </tr> <tr> <th>10</th> <td>Mammography 50 to 69 years of age</td> <td></td> <td></td> </tr> <tr> <th>11</th> <td>Difference in no. of eligible women screened</td> <td>1513 (505, 2521)</td> <td>(36)</td> </tr> <tr> <th>12</th> <td>Incidence of breast cancer</td> <td>.003165</td> <td>(42)</td> </tr> <tr> <th>13</th> <td>Cost of a mammogram</td> <td>$76.54</td> <td>(57)</td> </tr> <tr> <th>14</th> <td>Treatment costs saved for each breast cancer</td> <td>$2,522</td> <td>(42)</td> </tr> <tr> <th>15</th> <td>Hypertension Treatment</td> <td></td> <td></td> </tr> <tr> <th>16</th> <td>Difference in no. of eligible patients treated</td> <td>-145 (-739, 449)</td> <td>(36)</td> </tr> <tr> <th>17</th> <td>Efficacy of treatment of stroke</td> <td>.42</td> <td>(3)</td> </tr> <tr> <th>18</th> <td>Incidence of stroke</td> <td>.0018</td> <td>(47)</td> </tr> <tr> <th>19</th> <td>Efficacy of treatment of heart disease</td> <td>.14</td> <td>(3)</td> </tr> <tr> <th>20</th> <td>Incidence of heart disease</td> <td>.00196</td> <td>(47)</td> </tr> <tr> <th>21</th> <td>Treatment cost per case for stroke</td> <td>$3,815</td> <td>(56)</td> </tr> <tr> <th>22</th> <td>Treatment cost per case for heart disease</td> <td>$3,303</td> <td>(56)</td> </tr> <tr> <th>23</th> <td>STD Screening</td> <td></td> <td></td> </tr> <tr> <th>24</th> <td>Difference in no. of eligible patients screened</td> <td>645 (-253, 1542)</td> <td>(36)</td> </tr> <tr> <th>25</th> <td>Cost of gonorrhoeae and chlamydia culture</td> <td>$55</td> <td>(57)</td> </tr> <tr> <th>26</th> <td>Incidence of gonorrhoeae or Chlamydia infection</td> <td>.08</td> <td>(49)</td> </tr> <tr> <th>27</th> <td>Pelvic inflammatory disease (PID) prevented</td> <td>.14</td> <td>(50)</td> </tr> <tr> <th>28</th> <td>Treatment cost per case for PID</td> <td>$1,782</td> <td>(49)</td> </tr> <tr> <th>29</th> <td>Flu Vaccination</td> <td></td> <td></td> </tr> <tr> <th>30</th> <td>Difference in no. of eligible patients vaccinated</td> <td>3364(1928,4799)</td> <td>(36)</td> </tr> <tr> <th>31</th> <td>Cost of flu vaccination</td> <td>$3.75</td> <td>(43)</td> </tr> <tr> <th>32</th> <td>Pneumonia hospitalizations averted</td> <td>4.1 per 1000</td> <td>(43)</td> </tr> <tr> <th>33</th> <td>Chronic respiratory hospitalizations averted</td> <td>10.4 per 1000</td> <td>(43)</td> </tr> <tr> <th>34</th> <td>Congestive heart failure hospitalizations averted</td> <td>2 per 1000</td> <td>(43)</td> </tr> <tr> <th>35</th> <td>Emergency room visits avoided</td> <td>21.6 per 1000</td> <td>(43)</td> </tr> <tr> <th>36</th> <td>Emergency room visit cost</td> <td>$76.00</td> <td>(44)</td> </tr> <tr> <th>37</th> <td>Cost of pneumonia hospitalization</td> <td>$4,462</td> <td>(56)</td> </tr> <tr> <th>38</th> <td>Cost of chronic respiratory hospitalization</td> <td>$4,445</td> <td>(56)</td> </tr> <tr> <th>39</th> <td>Cost of heart failure hospitalization</td> <td>$5,417</td> <td>(56)</td> </tr> <tr> <th>40</th> <td>Cervical Cytology</td> <td></td> <td></td> </tr> <tr> <th>41</th> <td>Difference in no. of eligible patients screened</td> <td>2196 (559, 3833)</td> <td>(36)</td> </tr> <tr> <th>42</th> <td>Cost of PAP test</td> <td>$57.17</td> <td>(57)</td> </tr> <tr> <th>43</th> <td>Incidence of cervical cancer</td> <td>.00013</td> <td>(46)</td> </tr> <tr> <th>44</th> <td>Treatment costs saved for each women screened</td> <td>$9,813</td> <td>(41)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Variable</th> <th>Value and Rangea</th> <th>Source</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>D Manoeuvres</td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Blood Glucose Screening</td> <td></td> <td></td> </tr> <tr> <th>2</th> <td>Difference in eligible patients not screened</td> <td>4709 (2329,7089)</td> <td>(36)</td> </tr> <tr> <th>3</th> <td>Specificity of blood glucose test</td> <td>89%</td> <td>(3)</td> </tr> <tr> <th>4</th> <td>Cost of fasting glucose test</td> <td>$10.34</td> <td>(57)</td> </tr> <tr> <th>5</th> <td>Cost of glucose tolerance test</td> <td>$23.26</td> <td>(57)</td> </tr> <tr> <th>6</th> <td>Cost of HgA1c</td> <td>$19.12</td> <td>(57)</td> </tr> <tr> <th>7</th> <td>PSA Testing</td> <td></td> <td></td> </tr> <tr> <th>8</th> <td>Difference in eligible patients not screened</td> <td>95 (-932, 1122)</td> <td>(36)</td> </tr> <tr> <th>9</th> <td>Cost of PSA Test</td> <td>$25</td> <td>(57)</td> </tr> <tr> <th>10</th> <td>Specificity of PSA test</td> <td>40%</td> <td>(3)</td> </tr> <tr> <th>11</th> <td>Cost of Biopsy*</td> <td>$232.83</td> <td>(58)</td> </tr> <tr> <th>12</th> <td>Mammography 40 to 49</td> <td></td> <td></td> </tr> <tr> <th>13</th> <td>Difference in eligible patients not screened</td> <td>295 (-296, 887)</td> <td>(36)</td> </tr> <tr> <th>14</th> <td>Cost of mammogram</td> <td>$76.54</td> <td>(57)</td> </tr> <tr> <th>15</th> <td>Incidence of breast cancer</td> <td>.001616</td> <td>(42)</td> </tr> <tr> <th>16</th> <td>Specificity of mammogram</td> <td>96.5%</td> <td>(3)</td> </tr> <tr> <th>17</th> <td>Cost of Biopsy</td> <td>$2,164</td> <td>(42)</td> </tr> <tr> <th>18</th> <td>Chest X-Ray</td> <td></td> <td></td> </tr> <tr> <th>19</th> <td>Difference in eligible patients not screened</td> <td>276 (-271, 822)</td> <td>(36)</td> </tr> <tr> <th>20</th> <td>Cost of chest x-ray</td> <td>$233</td> <td>(40)</td> </tr> <tr> <th>21</th> <td>Urine Proteinuria Screening</td> <td></td> <td></td> </tr> <tr> <th>22</th> <td>Difference in eligible patients not screened</td> <td>9947 (7934,11961)</td> <td>(36)</td> </tr> <tr> <th>23</th> <td>Specificity of urine dipstick test</td> <td>95%</td> <td>(3)</td> </tr> <tr> <th>24</th> <td>Cost of Urine culture and urinalysis</td> <td>$27.18</td> <td>(57)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Condition</th> <th>Baseline</th> <th>Low</th> <th>High</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Breast Cancer</td> <td>$12,075.20</td> <td>$4,026.97</td> <td>$20,123.44</td> </tr> <tr> <th>1</th> <td>Influenza</td> <td>$254,633.54</td> <td>$145,976.01</td> <td>$363,291.07</td> </tr> <tr> <th>2</th> <td>Neural Tube Defects</td> <td>$174,999.39</td> <td>$99,997.21</td> <td>$250,001.56</td> </tr> <tr> <th>3</th> <td>Cervical cancer</td> <td>$2,154.49</td> <td>$548.05</td> <td>$3,760.92</td> </tr> <tr> <th>4</th> <td>Lung Cancer</td> <td>$122.27</td> <td>($518.51)</td> <td>$763.06</td> </tr> <tr> <th>5</th> <td>Heart Disease</td> <td>($808.13)</td> <td>($4,116.12)</td> <td>$2,499.86</td> </tr> <tr> <th>6</th> <td>STD Treatment</td> <td>$12,862.75</td> <td>($5,044.91)</td> <td>$30,770.42</td> </tr> <tr> <th>7</th> <td>Stroke</td> <td>($575.90)</td> <td>($2,933.28)</td> <td>$1,781.48</td> </tr> <tr> <th>8</th> <td>TOTAL</td> <td>$455,463.61</td> <td>$237,935.42</td> <td>$672,991.81</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Baseline</th> <th>Low</th> <th>High</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Costs</td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Intervention Cost</td> <td>$238,388</td> <td>$238,388</td> <td>$238,388</td> </tr> <tr> <th>2</th> <td>Manoeuvre Costs</td> <td>$192,911.62</td> <td>$42,581.43</td> <td>$343,241.78</td> </tr> <tr> <th>3</th> <td>Total Costs</td> <td>$431,299.62</td> <td>$280,969.43</td> <td>$581,629.78</td> </tr> <tr> <th>4</th> <td>Savings</td> <td></td> <td></td> <td></td> </tr> <tr> <th>5</th> <td>Inappropriate manoeuvre savings</td> <td>$148,568.44</td> <td>($175,897.93)</td> <td>$473,034.80</td> </tr> <tr> <th>6</th> <td>Treatment cost savings</td> <td>$455,463.61</td> <td>$237,935.42</td> <td>$672,991.81</td> </tr> <tr> <th>7</th> <td>Total Savings</td> <td>$604,032.05</td> <td>$62,037.49</td> <td>$1,146,026.61</td> </tr> <tr> <th>8</th> <td>NET Savings</td> <td>$172,732.44</td> <td>($218,931.95)</td> <td>$564,396.83</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Purpose</th> <th>Family Medicine [%]</th> <th>Specialist [%]</th> <th>χ2</th> <th>df</th> <th>p-value</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Personal use</td> <td>83.0</td> <td>86.4</td> <td>3.87</td> <td>1</td> <td>0.049</td> </tr> <tr> <th>1</th> <td>E-mail personal</td> <td>78.7</td> <td>81.7</td> <td>2.16</td> <td>1</td> <td>.14</td> </tr> <tr> <th>2</th> <td>Literature searching</td> <td>61.5</td> <td>74.2</td> <td>31.29</td> <td>1</td> <td>&lt; .0001</td> </tr> <tr> <th>3</th> <td>Accessing online journals</td> <td>57.6</td> <td>67.0</td> <td>14.40</td> <td>1</td> <td>.0001</td> </tr> <tr> <th>4</th> <td>Searching for patient-specific information</td> <td>66.7</td> <td>54.4</td> <td>21.23</td> <td>1</td> <td>.0001</td> </tr> <tr> <th>5</th> <td>Professional association updates</td> <td>47.3</td> <td>48.6</td> <td>0.32</td> <td>1</td> <td>.57</td> </tr> <tr> <th>6</th> <td>Consultation with colleagues</td> <td>11.7</td> <td>21.5</td> <td>21.66</td> <td>1</td> <td>&lt;.0001</td> </tr> <tr> <th>7</th> <td>Prescription/patient orders</td> <td>6.0</td> <td>3.4</td> <td>5.85</td> <td>1</td> <td>.02</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Percentiles</th> <th></th> <th>Boys</th> <th></th> <th>Girls</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>Q-max</td> <td>Q-Ave</td> <td>Q-max</td> <td>Q-Ave</td> </tr> <tr> <th>1</th> <td>5th</td> <td>A</td> <td>+0.155</td> <td>+0.087</td> <td>+0.55</td> <td>+0.51</td> </tr> <tr> <th>2</th> <td></td> <td>B</td> <td>+1.22</td> <td>+0.82</td> <td>-0.21</td> <td>+0.48</td> </tr> <tr> <th>3</th> <td>10th</td> <td>A</td> <td>+0.164</td> <td>+0.093</td> <td>+0.63</td> <td>+0.58</td> </tr> <tr> <th>4</th> <td></td> <td>B</td> <td>+1.39</td> <td>+0.92</td> <td>-0.36</td> <td>-0.65</td> </tr> <tr> <th>5</th> <td>25th</td> <td>A</td> <td>+0.189</td> <td>+0.124</td> <td>+0.54</td> <td>+0.67</td> </tr> <tr> <th>6</th> <td></td> <td>B</td> <td>+1.59</td> <td>+0.99</td> <td>+0.27</td> <td>-0.69</td> </tr> <tr> <th>7</th> <td>50th</td> <td>A</td> <td>+0.229</td> <td>+0.131</td> <td>+0.38</td> <td>+0.82</td> </tr> <tr> <th>8</th> <td></td> <td>B</td> <td>+1.67</td> <td>+1.25</td> <td>+1.23</td> <td>-1.09</td> </tr> <tr> <th>9</th> <td>75th</td> <td>A</td> <td>+0.245</td> <td>+0.138</td> <td>+0.28</td> <td>+0.85</td> </tr> <tr> <th>10</th> <td></td> <td>B</td> <td>2.11</td> <td>+1.53</td> <td>+1.90</td> <td>-0.89</td> </tr> <tr> <th>11</th> <td>90th</td> <td>A</td> <td>+0.207</td> <td>+0.14</td> <td>+0.33</td> <td>+0.86</td> </tr> <tr> <th>12</th> <td></td> <td>B</td> <td>+3.06</td> <td>+1.87</td> <td>+1.87</td> <td>-0.65</td> </tr> <tr> <th>13</th> <td>95th</td> <td>A</td> <td>+0.179</td> <td>+0.134</td> <td>+0.24</td> <td>+0.73</td> </tr> <tr> <th>14</th> <td></td> <td>B</td> <td>+3.77</td> <td>+2.29</td> <td>+2.39</td> <td>+0.33</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Scale</th> <th></th> <th></th> <th>Scale statistics</th> <th></th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Mean (SD) Total UK Sample</td> <td>Mean (SD) Total US Sample</td> <td>Percentage floor chronic health condition/healthy (UK Sample)</td> <td>Percentage floor chronic health condition/healthy (US Sample)</td> <td>Percentage ceiling chronic health condition/healthy (UK Sample)</td> <td>Percentage ceiling chronic health condition/healthy (US Sample)</td> </tr> <tr> <th>1</th> <td>Self-report</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>2</th> <td>Total score</td> <td>82.25 (13.09)</td> <td>79.62 (15.26)</td> <td>0.0/0.0</td> <td>0.0/0.0</td> <td>1.4/3.2</td> <td>1.9/7.2</td> </tr> <tr> <th>3</th> <td>Physical health</td> <td>86.08 (14.06)</td> <td>80.19 (19.30)</td> <td>0.3/0.0</td> <td>0.0/0.0</td> <td>12.1/20.5</td> <td>13.1/25.8</td> </tr> <tr> <th>4</th> <td>Psychosocial health</td> <td>80.50 (14.06)</td> <td>79.37 (15.70)</td> <td>0.0/0.0</td> <td>0.0/0.0</td> <td>2.5/4.1</td> <td>5.2/12.0</td> </tr> <tr> <th>5</th> <td>Emotional functioning</td> <td>76.99 (18.43)</td> <td>78.10 (20.66)</td> <td>0.0/0.0</td> <td>0.3/0.8</td> <td>4.9/15.6</td> <td>22.4/29.8</td> </tr> <tr> <th>6</th> <td>Social functioning</td> <td>86.85 (16.86)</td> <td>84.09 (18.50)</td> <td>0.3/0.2</td> <td>0.0/0.0</td> <td>35.3/41.4</td> <td>33.2/47.1</td> </tr> <tr> <th>7</th> <td>School functioning</td> <td>77.29 (16.92)</td> <td>75.87 (19.71)</td> <td>0.0/0.1</td> <td>0.3/0.5</td> <td>8.2/11.1</td> <td>13.0/23.1</td> </tr> <tr> <th>8</th> <td>Proxy-report</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>9</th> <td>Total score</td> <td>81.12 (13.85)</td> <td>80.87 (16.73)</td> <td>0.0/0.0</td> <td>0.2/0.0</td> <td>0.7/3.6</td> <td>4.1/10.3</td> </tr> <tr> <th>10</th> <td>Physical health</td> <td>84.99 (16.08)</td> <td>81.38 (23.18)</td> <td>0.0/0.1</td> <td>2.3/0.0</td> <td>7.4/26.7</td> <td>18.5/39.6</td> </tr> <tr> <th>11</th> <td>Psychosocial health</td> <td>79.00 (14.70)</td> <td>80.53 (16.52)</td> <td>0.0/0.0</td> <td>0.2/0.0</td> <td>1.7/4.6</td> <td>5.6/13.8</td> </tr> <tr> <th>12</th> <td>Emotional functioning</td> <td>74.67 (17.67)</td> <td>77.95 (20.67)</td> <td>0.0/0.1</td> <td>1.4/0.1</td> <td>6.1/12.1</td> <td>19.5/29.5</td> </tr> <tr> <th>13</th> <td>Social functioning</td> <td>84.62 (17.24)</td> <td>85.38 (19.17)</td> <td>0.3/0.0</td> <td>0.5/0.0</td> <td>26.3/37.6</td> <td>34.4/58.1</td> </tr> <tr> <th>14</th> <td>School functioning</td> <td>77.72 (18.50)</td> <td>77.80 (22.00)</td> <td>0.3/0.0</td> <td>1.7/0.3</td> <td>8.5/17.9</td> <td>15.5/34.5</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Scale</th> <th></th> <th>Self-report</th> <th></th> <th></th> <th></th> <th>Proxy-report</th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>N</td> <td>Mean (sd)</td> <td>df</td> <td>F</td> <td>N</td> <td>Mean (sd)</td> <td>df</td> <td>F</td> </tr> <tr> <th>1</th> <td>Total Score</td> <td></td> <td></td> <td>4,1393</td> <td>23.84</td> <td></td> <td></td> <td>4,965</td> <td>41.07</td> </tr> <tr> <th>2</th> <td>Asthma</td> <td>99</td> <td>75.31(16.90) ***</td> <td></td> <td></td> <td>74</td> <td>71.79(17.53)***</td> <td></td> <td></td> </tr> <tr> <th>3</th> <td>Diabetes</td> <td>124</td> <td>82.46(12.76)</td> <td></td> <td></td> <td>103</td> <td>77.54(12.21) ***</td> <td></td> <td></td> </tr> <tr> <th>4</th> <td>Cancer</td> <td>66</td> <td>75.68(15.40) ***</td> <td></td> <td></td> <td>61</td> <td>70.96(17.06) ***</td> <td></td> <td></td> </tr> <tr> <th>5</th> <td>IBD</td> <td>76</td> <td>74.18(14.66) ***</td> <td></td> <td></td> <td>67</td> <td>72.65(17.62) ***</td> <td></td> <td></td> </tr> <tr> <th>6</th> <td>Healthy</td> <td>1033</td> <td>83.89(11.84)</td> <td></td> <td></td> <td>665</td> <td>84.61(11.19)</td> <td></td> <td></td> </tr> <tr> <th>7</th> <td>Physical Health</td> <td></td> <td></td> <td>4,1392</td> <td>41.60</td> <td></td> <td></td> <td>4,964</td> <td>46.87</td> </tr> <tr> <th>8</th> <td>Asthma</td> <td>99</td> <td>76.14(19.10)***</td> <td></td> <td></td> <td>75</td> <td>73.36(20.60) ***</td> <td></td> <td></td> </tr> <tr> <th>9</th> <td>Diabetes</td> <td>124</td> <td>84.75(13.65)**</td> <td></td> <td></td> <td>103</td> <td>82.97(13.67) ***</td> <td></td> <td></td> </tr> <tr> <th>10</th> <td>Cancer</td> <td>66</td> <td>78.10(17.64) ***</td> <td></td> <td></td> <td>61</td> <td>75.04(18.79) ***</td> <td></td> <td></td> </tr> <tr> <th>11</th> <td>IBD</td> <td>76</td> <td>75.08(18.21) ***</td> <td></td> <td></td> <td>67</td> <td>71.54(21.98) ***</td> <td></td> <td></td> </tr> <tr> <th>12</th> <td>Healthy</td> <td>1032</td> <td>88.51(11.62)</td> <td></td> <td></td> <td>665</td> <td>89.06(12.27)</td> <td></td> <td></td> </tr> <tr> <th>13</th> <td>Psychosocial Health</td> <td></td> <td></td> <td>4,1393</td> <td>14.53</td> <td></td> <td></td> <td>4,964</td> <td>28.16</td> </tr> <tr> <th>14</th> <td>Asthma</td> <td>99</td> <td>74.9(17.48) ***</td> <td></td> <td></td> <td>74</td> <td>71.20(17.95) ***</td> <td></td> <td></td> </tr> <tr> <th>15</th> <td>Diabetes</td> <td>124</td> <td>81.24(13.77)</td> <td></td> <td></td> <td>103</td> <td>74.62(13.27) ***</td> <td></td> <td></td> </tr> <tr> <th>16</th> <td>Cancer</td> <td>66</td> <td>74.37(15.85) ***</td> <td></td> <td></td> <td>61</td> <td>68.83(17.92) ***</td> <td></td> <td></td> </tr> <tr> <th>17</th> <td>IBD</td> <td>76</td> <td>73.64(14.35) ***</td> <td></td> <td></td> <td>67</td> <td>73.21(17.43) ***</td> <td></td> <td></td> </tr> <tr> <th>18</th> <td>Healthy</td> <td>1033</td> <td>81.84(13.21)</td> <td></td> <td></td> <td>664</td> <td>82.21(12.67)</td> <td></td> <td></td> </tr> <tr> <th>19</th> <td>Emotional functioning</td> <td></td> <td></td> <td>4,1393</td> <td>9.85</td> <td></td> <td></td> <td>4,962</td> <td>23.24</td> </tr> <tr> <th>20</th> <td>Asthma</td> <td>99</td> <td>70.66(20.06) ***</td> <td></td> <td></td> <td>74</td> <td>67.23(21.20) ***</td> <td></td> <td></td> </tr> <tr> <th>21</th> <td>Diabetes</td> <td>124</td> <td>78.85(18.28)</td> <td></td> <td></td> <td>102</td> <td>66.01(17.80) ***</td> <td></td> <td></td> </tr> <tr> <th>22</th> <td>Cancer</td> <td>66</td> <td>73.56(18.39) *</td> <td></td> <td></td> <td>61</td> <td>68.36(18.04) ***</td> <td></td> <td></td> </tr> <tr> <th>23</th> <td>IBD</td> <td>76</td> <td>68.11(18.90) ***</td> <td></td> <td></td> <td>67</td> <td>67.26(21.41) ***</td> <td></td> <td></td> </tr> <tr> <th>24</th> <td>Healthy</td> <td>1033</td> <td>78.49(17.94)</td> <td></td> <td></td> <td>663</td> <td>78.28(15.54)</td> <td></td> <td></td> </tr> <tr> <th>25</th> <td>Social functioning</td> <td></td> <td></td> <td>4,1393</td> <td>5.89</td> <td></td> <td></td> <td>4,964</td> <td>14.09</td> </tr> <tr> <th>26</th> <td>Asthma</td> <td>99</td> <td>81.76(21.35) ***</td> <td></td> <td></td> <td>74</td> <td>76.96(21.69) ***</td> <td></td> <td></td> </tr> <tr> <th>27</th> <td>Diabetes</td> <td>124</td> <td>89.15(13.91)</td> <td></td> <td></td> <td>103</td> <td>85.28(15.98)</td> <td></td> <td></td> </tr> <tr> <th>28</th> <td>Cancer</td> <td>66</td> <td>81.27(18.36) **</td> <td></td> <td></td> <td>61</td> <td>73.28(22.93) ***</td> <td></td> <td></td> </tr> <tr> <th>29</th> <td>IBD</td> <td>76</td> <td>83.82(16.61)</td> <td></td> <td></td> <td>67</td> <td>82.12(18.09) *</td> <td></td> <td></td> </tr> <tr> <th>30</th> <td>Healthy</td> <td>1033</td> <td>87.65(16.46)</td> <td></td> <td></td> <td>664</td> <td>86.82(15.42)</td> <td></td> <td></td> </tr> <tr> <th>31</th> <td>School functioning</td> <td></td> <td></td> <td>4,1386</td> <td>14.12</td> <td></td> <td></td> <td>4,960</td> <td>26.90</td> </tr> <tr> <th>32</th> <td>Asthma</td> <td>99</td> <td>72.37(19.62) ***</td> <td></td> <td></td> <td>74</td> <td>69.02(22.55) ***</td> <td></td> <td></td> </tr> <tr> <th>33</th> <td>Diabetes</td> <td>124</td> <td>77.70(17.39)</td> <td></td> <td></td> <td>103</td> <td>72.62(17.64) ***</td> <td></td> <td></td> </tr> <tr> <th>34</th> <td>Cancer</td> <td>63</td> <td>67.38(20.36) ***</td> <td></td> <td></td> <td>58</td> <td>63.45(21.71) ***</td> <td></td> <td></td> </tr> <tr> <th>35</th> <td>IBD</td> <td>73</td> <td>69.52(17.28) ***</td> <td></td> <td></td> <td>66</td> <td>70.46(20.95) ***</td> <td></td> <td></td> </tr> <tr> <th>36</th> <td>Healthy</td> <td>1032</td> <td>78.87(15.89)</td> <td></td> <td></td> <td>664</td> <td>81.52(16.09)</td> <td></td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Scale:</th> <th>Total Sample</th> <th>Healthy children</th> <th>Children with chronic health condition</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Total score</td> <td>0.56*</td> <td>0.32*</td> <td>0.67*</td> </tr> <tr> <th>1</th> <td>Physical health</td> <td>0.53*</td> <td>0.20*</td> <td>0.61*</td> </tr> <tr> <th>2</th> <td>Psychosocial health</td> <td>0.51*</td> <td>0.34*</td> <td>0.63*</td> </tr> <tr> <th>3</th> <td>Emotional functioning</td> <td>0.41*</td> <td>0.27*</td> <td>0.51*</td> </tr> <tr> <th>4</th> <td>Social functioning</td> <td>0.50*</td> <td>0.42*</td> <td>0.60*</td> </tr> <tr> <th>5</th> <td>School functioning</td> <td>0.49*</td> <td>0.32*</td> <td>0.56*</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Base Model</th> <th>Spatial Distribution Function of Alternative Model</th> <th>Base Model Observed Dataset</th> <th>More Explicit Model Observed Dataset</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Null</td> <td>Distance Decline</td> <td>Relative Risk = 1</td> <td>Distance Decline Relative Risk</td> </tr> <tr> <th>1</th> <td>Null</td> <td>Direction</td> <td>Relative Risk = 1</td> <td>Directional Relative Risk</td> </tr> <tr> <th>2</th> <td>Null</td> <td>Peaked Distance Decline</td> <td>Relative Risk = 1</td> <td>Peaked Distance Decline Relative Risk</td> </tr> <tr> <th>3</th> <td>Null</td> <td>Distance Decline and Direction</td> <td>Relative Risk = 1</td> <td>Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>4</th> <td>Null</td> <td>Peaked Distance Decline and Direction</td> <td>Relative Risk = 1</td> <td>Peaked Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>5</th> <td>Distance Decline</td> <td>Distance Decline and Direction</td> <td>Distance Decline Relative Risk</td> <td>Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>6</th> <td>Distance Decline</td> <td>Peaked Distance Decline</td> <td>Distance Decline Relative Risk</td> <td>Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>7</th> <td>Distance Decline</td> <td>Peaked Distance Decline and Direction</td> <td>Distance Decline Relative Risk</td> <td>Peaked Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>8</th> <td>Direction</td> <td>Distance Decline and Direction</td> <td>Directional Relative Risk</td> <td>Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>9</th> <td>Direction</td> <td>Peaked Distance Decline and Direction</td> <td>Directional Relative Risk</td> <td>Peaked Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>10</th> <td>Peaked Distance Decline</td> <td>Peaked Distance Decline and Direction</td> <td>Peaked Distance Decline Relative Risk</td> <td>Peaked Distance Decline and Direction Relative Risk</td> </tr> <tr> <th>11</th> <td>Distance Decline and Direction</td> <td>Peaked Distance Decline and Direction</td> <td>Distance Decline and Direction Relative Risk</td> <td>Peaked Distance Decline and Direction Relative Risk</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Author</th> <th>Year</th> <th>No of cases</th> <th>Results</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Zahner et al [15]</td> <td>1994</td> <td>1</td> <td>Positive</td> </tr> <tr> <th>1</th> <td>Cadigan et al [7]</td> <td>1995</td> <td>1</td> <td>Positive</td> </tr> <tr> <th>2</th> <td>Teh et al [16]</td> <td>1998</td> <td>3</td> <td>Positive</td> </tr> <tr> <th>3</th> <td>Lastoria et al [8]</td> <td>1998</td> <td>3</td> <td>Positive</td> </tr> <tr> <th>4</th> <td>Satta et al [9]</td> <td>1999</td> <td>2</td> <td>Positive</td> </tr> <tr> <th>5</th> <td>Grimfjard et al [17]</td> <td>2002</td> <td>3</td> <td>2 positive/1 Negative</td> </tr> <tr> <th>6</th> <td>Gibril et al [5]*</td> <td>2003</td> <td>8</td> <td>Positive</td> </tr> <tr> <th>7</th> <td>Plachcinska et al [18]**</td> <td>2004</td> <td>1</td> <td>Positive</td> </tr> <tr> <th>8</th> <td>Loehrer et al [10]</td> <td>2004</td> <td>6</td> <td>Positive</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Time (h)</th> <th>Type</th> <th></th> <th></th> <th>Duration</th> <th></th> <th></th> <th>Time (h)</th> <th></th> <th></th> <th>Duration</th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>Oscillation</td> <td>type</td> <td>Fetal movements</td> <td></td> <td>Recording</td> <td></td> <td>Oscillation</td> <td>type</td> <td>Fetal movements</td> <td></td> <td>Recording</td> </tr> <tr> <th>1</th> <td></td> <td></td> <td>Min</td> <td>Sec.</td> <td>Min</td> <td>Sec.</td> <td>Min</td> <td></td> <td>Min</td> <td>Sec.</td> <td>Min</td> <td>Sec.</td> <td>Min</td> </tr> <tr> <th>2</th> <td>19–20</td> <td>I</td> <td>3 ± 0.1</td> <td>-</td> <td>4</td> <td>50 ± 0</td> <td>54 ± 0.1</td> <td>24–1</td> <td>2 ± 0.2</td> <td>-</td> <td>4 ± 0.1</td> <td>-</td> <td>53 ± 0.2</td> </tr> <tr> <th>3</th> <td></td> <td>II</td> <td>15 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>14 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>4</th> <td></td> <td>III</td> <td>4 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>4 ± 0.4</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>5</th> <td></td> <td>IV</td> <td>32 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>33 ± 0.4</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>6</th> <td>20–21</td> <td>I</td> <td>-</td> <td>10 ± 0.2</td> <td>4 ± 0.2</td> <td>-</td> <td>30 ± 0.2</td> <td>1 – 2</td> <td>1 ± 0.1</td> <td>-</td> <td>6 ± 0.3</td> <td>-</td> <td>34 ± 0.4</td> </tr> <tr> <th>7</th> <td></td> <td>II</td> <td>10 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>11 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>8</th> <td></td> <td>III</td> <td>5 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>7 ± 0.4</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>9</th> <td></td> <td>IV</td> <td>15 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>15 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>10</th> <td>21–22</td> <td>I</td> <td>-</td> <td>-</td> <td>3 ± 0.1</td> <td>-</td> <td>39 ± 0.3</td> <td>2 – 3</td> <td>1 ± 0.2</td> <td>-</td> <td>4 ± 0.2</td> <td>-</td> <td>53 ± 0.1</td> </tr> <tr> <th>11</th> <td></td> <td>II</td> <td>12 ± 0.4</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>18 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>12</th> <td></td> <td>III</td> <td>22 ± 0.4</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>7 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>13</th> <td></td> <td>IV</td> <td>15 ± 0.3</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>27 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>14</th> <td>22–23</td> <td>I</td> <td>I</td> <td>40 ± 0.2</td> <td>16 ± 0.2</td> <td>-</td> <td>26 ± 0.3</td> <td>3 – 4</td> <td>-</td> <td>30 ± 0.3</td> <td>3</td> <td>30 ± 0.2</td> <td>31 ± 0.2</td> </tr> <tr> <th>15</th> <td></td> <td>II</td> <td>7 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>9 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>16</th> <td></td> <td>III</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>7 ± 0.1</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>17</th> <td></td> <td>IV</td> <td>18 ± 0.3</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>15 ± 0.3</td> <td>-</td> <td>-</td> <td>-</td> <td></td> </tr> <tr> <th>18</th> <td>23–24</td> <td>I</td> <td>1 ± 0.3</td> <td>-</td> <td>3 ± 0.2</td> <td>-</td> <td>58 ± 0.1</td> <td>Total from 19-4</td> <td>12</td> <td>20 ± 0.21</td> <td>43</td> <td>20 ± 0.16</td> <td>388 ± 0.21</td> </tr> <tr> <th>19</th> <td></td> <td>II</td> <td>23 ± 0.3</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>123 ± 0.15</td> <td>-</td> <td></td> <td></td> <td></td> </tr> <tr> <th>20</th> <td></td> <td>III</td> <td>5 ± 0.2</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>44 ± 0.17</td> <td>-</td> <td></td> <td></td> <td></td> </tr> <tr> <th>21</th> <td></td> <td>IV</td> <td>29 ± 0.4</td> <td>-</td> <td>-</td> <td>-</td> <td></td> <td></td> <td>200 ± 0.26</td> <td>-</td> <td></td> <td></td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Sitea</th> <th>Enzymeb</th> <th>Gene Card</th> <th>UniGenec</th> <th>SAGEc</th> <th>Full Name</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>163</td> <td>EGFR Kinase</td> <td>EGFR</td> <td>Yes</td> <td>No</td> <td>EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb- b) oncogene homolog, avian))</td> </tr> <tr> <th>1</th> <td></td> <td>Insulin Receptor Kinase</td> <td>INSR</td> <td>Yes</td> <td>Yes</td> <td>INSR (insulin receptor)</td> </tr> <tr> <th>2</th> <td></td> <td>p85 SH2</td> <td>PIK3R1</td> <td>Yes</td> <td>Yes</td> <td>PIK3R1 (phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha))</td> </tr> <tr> <th>3</th> <td></td> <td>Shc SH2</td> <td>SHC1</td> <td>No</td> <td>No</td> <td>SHC1 (SHC (Src homology 2 domain containing) transforming protein 1)</td> </tr> <tr> <th>4</th> <td>286</td> <td>EGFR Kinase</td> <td>EGFR</td> <td>Yes</td> <td>No</td> <td>EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb- b) oncogene homolog, avian))</td> </tr> <tr> <th>5</th> <td>313</td> <td>EGFR Kinase</td> <td>EGFR</td> <td>Yes</td> <td>No</td> <td>EGFR (epidermal growth factor receptor (erythroblastic leukemia viral (v-erb- b) oncogene homolog, avian))</td> </tr> <tr> <th>6</th> <td></td> <td>Fgr Kinase</td> <td>FGR</td> <td>No</td> <td>No</td> <td>FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog)</td> </tr> <tr> <th>7</th> <td></td> <td>PDGFR Kin</td> <td>PDGFRB</td> <td>No</td> <td>Yes</td> <td>PDGFRB (platelet-derived growth factor receptor, beta polypeptide)</td> </tr> <tr> <th>8</th> <td></td> <td>Itk SH2</td> <td>ITK</td> <td>No</td> <td>No</td> <td>ITK (IL2-inducible T-cell kinase)</td> </tr> <tr> <th>9</th> <td></td> <td>Fgr SH2</td> <td>FGR</td> <td>No</td> <td>No</td> <td>FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog)</td> </tr> <tr> <th>10</th> <td>719</td> <td>Lck Kinase</td> <td>LCK</td> <td>No</td> <td>No</td> <td>LCK (lymphocyte-specific protein tyrosine kinase)</td> </tr> <tr> <th>11</th> <td></td> <td>Abl Kinase</td> <td>ABL1</td> <td>No</td> <td>Yes</td> <td>ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1)</td> </tr> <tr> <th>12</th> <td></td> <td>Itk SH2</td> <td>ITK</td> <td>No</td> <td>No</td> <td>ITK (IL2-inducible T-cell kinase)</td> </tr> <tr> <th>13</th> <td></td> <td>Src Kinase</td> <td>SRC</td> <td>Yes</td> <td>No</td> <td>SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))</td> </tr> <tr> <th>14</th> <td>149 2</td> <td>Src Kinase</td> <td>SRC</td> <td>Yes</td> <td>No</td> <td>SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))</td> </tr> <tr> <th>15</th> <td></td> <td>Lck SH2</td> <td>LCK</td> <td>No</td> <td>No</td> <td>LCK (lymphocyte-specific protein tyrosine kinase)</td> </tr> <tr> <th>16</th> <td></td> <td>Fgr SH2</td> <td>FGR</td> <td>No</td> <td>No</td> <td>FGR (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog)</td> </tr> <tr> <th>17</th> <td></td> <td>Src SH2</td> <td>SRC</td> <td>Yes</td> <td>No</td> <td>SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))</td> </tr> <tr> <th>18</th> <td>185 6</td> <td>Lck Kinase</td> <td>LCK</td> <td>No</td> <td>No</td> <td>LCK (lymphocyte-specific protein tyrosine kinase)</td> </tr> <tr> <th>19</th> <td></td> <td>Src Kinase</td> <td>SRC</td> <td>Yes</td> <td>No</td> <td>SRC (v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian))</td> </tr> <tr> <th>20</th> <td></td> <td>Abl Kinase</td> <td>ABL1</td> <td>No</td> <td>Yes</td> <td>ABL1 (v-abl Abelson murine leukemia viral oncogene homolog 1)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Nature (12/00)</th> <th>Release 1 (8/01)</th> <th>Release 2 (1/02)</th> <th>Release 3 (8/02)</th> <th>Release 4 (4/03)</th> <th>Release 5 (1/04)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Genome size (Mb)</td> <td>115.410</td> <td>116.238</td> <td>117.227</td> <td>117.077</td> <td>119.055</td> <td>118.998</td> </tr> <tr> <th>1</th> <td>protein-coding genes</td> <td>25,498</td> <td>25,554</td> <td>26,156</td> <td>27,117</td> <td>27,170</td> <td>26,207</td> </tr> <tr> <th>2</th> <td>transposons and pseudogenes</td> <td>NA</td> <td>1,274</td> <td>1,305</td> <td>1,967</td> <td>2,218</td> <td>3,786</td> </tr> <tr> <th>3</th> <td>Genes annotated as alternatively spliced</td> <td>NA</td> <td>0</td> <td>28</td> <td>162</td> <td>1,267</td> <td>2,330</td> </tr> <tr> <th>4</th> <td>genes with UTRs</td> <td>NA</td> <td>4,140</td> <td>10,219</td> <td>11,691</td> <td>17,060</td> <td>18,099</td> </tr> <tr> <th>5</th> <td>Protein-coding genes similar to transposon ORFsa</td> <td>NA</td> <td>487</td> <td>485</td> <td>528</td> <td>531</td> <td>6</td> </tr> <tr> <th>6</th> <td>gene density (kb per gene)</td> <td>4.5</td> <td>4.55</td> <td>4.48</td> <td>4.32</td> <td>4.38</td> <td>4.54</td> </tr> <tr> <th>7</th> <td>exons / gene</td> <td>5.2</td> <td>5.23</td> <td>5.25</td> <td>5.24</td> <td>5.31</td> <td>5.42</td> </tr> <tr> <th>8</th> <td>average exon length (bp)</td> <td>250</td> <td>256</td> <td>265</td> <td>266</td> <td>279</td> <td>276</td> </tr> <tr> <th>9</th> <td>average intron length (bp)</td> <td>168</td> <td>168</td> <td>167</td> <td>166</td> <td>166</td> <td>164</td> </tr> <tr> <th>10</th> <td>Gene structures altered since previous release. (u,a,d,m,s)</td> <td>NA</td> <td>-</td> <td>u: 2,853 a: 690 d: 231 m: 14 s: 167</td> <td>u:1,366 a: 1,906 d: 221 m: 62 s: 14</td> <td>u: 2,347 a: 527 d: 143 m: 153 s: 24</td> <td>u: 2,858 a: 1,393 d: 730 m: 169 s: 28</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Transposable element classification</th> <th># Annotated genomic regions</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Class I (Retrotransposons)</td> <td>1652</td> </tr> <tr> <th>1</th> <td>gypsy-like retrotransposon family (Athila)</td> <td>511</td> </tr> <tr> <th>2</th> <td>gypsy-like retrotransposon family</td> <td>374</td> </tr> <tr> <th>3</th> <td>copia-like retrotransposon family</td> <td>494</td> </tr> <tr> <th>4</th> <td>non-LTR retrotransposon family (LINE)</td> <td>264</td> </tr> <tr> <th>5</th> <td>other</td> <td>9</td> </tr> <tr> <th>6</th> <td>Class II (DNA transposons)</td> <td>703</td> </tr> <tr> <th>7</th> <td>hAT-like transposase family (hobo/Ac/Tam3)</td> <td>77</td> </tr> <tr> <th>8</th> <td>CACTA-like transposase family (En/Spm)</td> <td>69</td> </tr> <tr> <th>9</th> <td>CACTA-like transposase family (Ptta/En/Spm)</td> <td>127</td> </tr> <tr> <th>10</th> <td>CACTA-like transposase family (Tnp1/En/Spm)</td> <td>37</td> </tr> <tr> <th>11</th> <td>CACTA-like transposase family (Tnp2/En/Spm)</td> <td>102</td> </tr> <tr> <th>12</th> <td>Mutator-like transposase family</td> <td>268</td> </tr> <tr> <th>13</th> <td>Mariner-like transposase family</td> <td>9</td> </tr> <tr> <th>14</th> <td>other</td> <td>14</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Amino Acid</th> <th>Overall composition</th> <th>All Genes (3462)</th> <th>Proteins (&gt;100 residues)</th> <th>Membrane Proteins</th> <th>Non-Membrane Proteins</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>A</td> <td>5.49</td> <td>0.336</td> <td>0.361</td> <td>0.401</td> <td>0.340</td> </tr> <tr> <th>1</th> <td>C</td> <td>1.26</td> <td>-0.003</td> <td>-0.102</td> <td>0.030</td> <td>0.000</td> </tr> <tr> <th>2</th> <td>D</td> <td>5.58</td> <td>-0.168</td> <td>-0.152</td> <td>-0.147</td> <td>-0.207</td> </tr> <tr> <th>3</th> <td>E</td> <td>6.54</td> <td>-0.061</td> <td>-0.045</td> <td>-0.105</td> <td>-0.088</td> </tr> <tr> <th>4</th> <td>F</td> <td>4.42</td> <td>-0.122</td> <td>-0.109</td> <td>-0.093</td> <td>-0.107</td> </tr> <tr> <th>5</th> <td>G</td> <td>4.98</td> <td>0.215</td> <td>0.217</td> <td>0.127</td> <td>0.231</td> </tr> <tr> <th>6</th> <td>H</td> <td>2.23</td> <td>-0.052</td> <td>-0.056</td> <td>-0.131</td> <td>-0.048</td> </tr> <tr> <th>7</th> <td>I</td> <td>6.56</td> <td>-0.136</td> <td>-0.116</td> <td>-0.091</td> <td>-0.128</td> </tr> <tr> <th>8</th> <td>K</td> <td>7.35</td> <td>0.166</td> <td>0.158</td> <td>-0.117</td> <td>0.182</td> </tr> <tr> <th>9</th> <td>L</td> <td>9.50</td> <td>-0.208</td> <td>-0.191</td> <td>-0.131</td> <td>-0.212</td> </tr> <tr> <th>10</th> <td>M</td> <td>2.08</td> <td>-0.087</td> <td>-0.098</td> <td>-0.003</td> <td>-0.094</td> </tr> <tr> <th>11</th> <td>N</td> <td>6.17</td> <td>-0.210</td> <td>-0.220</td> <td>-0.209</td> <td>-0.226</td> </tr> <tr> <th>12</th> <td>P</td> <td>4.37</td> <td>-0.064</td> <td>-0.057</td> <td>0.039</td> <td>-0.086</td> </tr> <tr> <th>13</th> <td>Q</td> <td>3.96</td> <td>-0.052</td> <td>-0.061</td> <td>-0.072</td> <td>-0.065</td> </tr> <tr> <th>14</th> <td>R</td> <td>4.43</td> <td>0.204</td> <td>0.183</td> <td>-0.260</td> <td>0.240</td> </tr> <tr> <th>15</th> <td>S</td> <td>8.98</td> <td>-0.152</td> <td>-0.159</td> <td>0.013</td> <td>-0.180</td> </tr> <tr> <th>16</th> <td>T</td> <td>5.92</td> <td>0.008</td> <td>0.003</td> <td>0.279</td> <td>-0.036</td> </tr> <tr> <th>17</th> <td>V</td> <td>5.56</td> <td>0.269</td> <td>0.298</td> <td>0.214</td> <td>0.294</td> </tr> <tr> <th>18</th> <td>W</td> <td>1.04</td> <td>-0.072</td> <td>-0.077</td> <td>-0.043</td> <td>-0.055</td> </tr> <tr> <th>19</th> <td>Y</td> <td>3.38</td> <td>-0.009</td> <td>-0.018</td> <td>-0.030</td> <td>0.018</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Method</th> <th>FP</th> <th>FN</th> <th>TP</th> <th>TN</th> <th>S(M)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>GEM</td> <td>4</td> <td>6</td> <td>115</td> <td>2340</td> <td>226</td> </tr> <tr> <th>1</th> <td>AACM</td> <td>8</td> <td>22</td> <td>99</td> <td>2336</td> <td>190</td> </tr> <tr> <th>2</th> <td>GEM + AACM</td> <td>4</td> <td>2</td> <td>119</td> <td>2340</td> <td>234</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Percent Composition</th> <th>Ala</th> <th></th> <th>Gly</th> <th></th> <th>Arg</th> <th></th> <th>Val</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Genes *</td> <td>E. Level **</td> <td>Genes</td> <td>E. Level</td> <td>Genes</td> <td>E. Level</td> <td>Genes</td> <td>E. Level</td> </tr> <tr> <th>1</th> <td>1 – 3</td> <td>152</td> <td>2.15</td> <td>333</td> <td>2.82</td> <td>543</td> <td>3.70</td> <td>543</td> <td>3.70</td> </tr> <tr> <th>2</th> <td>3 – 5</td> <td>1063</td> <td>2.05</td> <td>1166</td> <td>2.39</td> <td>1728</td> <td>2.86</td> <td>1728</td> <td>2.86</td> </tr> <tr> <th>3</th> <td>5 – 7</td> <td>1204</td> <td>2.75</td> <td>1176</td> <td>3.61</td> <td>798</td> <td>2.85</td> <td>798</td> <td>2.85</td> </tr> <tr> <th>4</th> <td>7 – 9</td> <td>613</td> <td>4.86</td> <td>510</td> <td>6.14</td> <td>194</td> <td>7.52</td> <td>194</td> <td>7.52</td> </tr> <tr> <th>5</th> <td>9 – 11</td> <td>242</td> <td>9.19</td> <td>155</td> <td>7.39</td> <td>55</td> <td>19.58</td> <td>55</td> <td>19.58</td> </tr> <tr> <th>6</th> <td>11 – 13</td> <td>61</td> <td>15.19</td> <td>33</td> <td>12.64</td> <td>23</td> <td>17.30</td> <td>23</td> <td>17.30</td> </tr> <tr> <th>7</th> <td>13 – 15</td> <td>30</td> <td>15.81</td> <td>15</td> <td>12.73</td> <td>5</td> <td>29.86</td> <td>5</td> <td>29.86</td> </tr> <tr> <th>8</th> <td>&gt; 15</td> <td>32</td> <td>16.52</td> <td>7</td> <td>13.54</td> <td>2</td> <td>12.85</td> <td>2</td> <td>12.85</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Percent Composition</th> <th>Asp</th> <th></th> <th>Leu</th> <th></th> <th>Asn</th> <th></th> <th>Ser</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Genes*</td> <td>E. Level**</td> <td>Genes</td> <td>E. Level</td> <td>Genes</td> <td>E. Level</td> <td>Genes</td> <td>E. Level</td> </tr> <tr> <th>1</th> <td>1 – 3</td> <td>260</td> <td>9.81</td> <td>20</td> <td>14.06</td> <td>249</td> <td>8.69</td> <td>31</td> <td>12.52</td> </tr> <tr> <th>2</th> <td>3 – 5</td> <td>847</td> <td>3.97</td> <td>114</td> <td>12.19</td> <td>1195</td> <td>5.21</td> <td>264</td> <td>7.85</td> </tr> <tr> <th>3</th> <td>5 – 7</td> <td>1505</td> <td>3.35</td> <td>467</td> <td>6.20</td> <td>1323</td> <td>2.96</td> <td>907</td> <td>5.39</td> </tr> <tr> <th>4</th> <td>7 – 9</td> <td>657</td> <td>3.10</td> <td>1033</td> <td>4.05</td> <td>478</td> <td>1.72</td> <td>1202</td> <td>3.41</td> </tr> <tr> <th>5</th> <td>9 – 11</td> <td>117</td> <td>3.15</td> <td>1118</td> <td>3.09</td> <td>148</td> <td>1.83</td> <td>645</td> <td>2.06</td> </tr> <tr> <th>6</th> <td>11 – 13</td> <td>32</td> <td>2.38</td> <td>526</td> <td>2.42</td> <td>34</td> <td>3.15</td> <td>221</td> <td>2.77</td> </tr> <tr> <th>7</th> <td>13 – 15</td> <td>10</td> <td>2.86</td> <td>151</td> <td>1.98</td> <td>11</td> <td>0.95</td> <td>103</td> <td>1.98</td> </tr> <tr> <th>8</th> <td>15</td> <td>5</td> <td>1.22</td> <td>32</td> <td>2.57</td> <td>9</td> <td>1.14</td> <td>87</td> <td>3.16</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Amino Acid</th> <th>Alternate</th> <th>Dataset 1 (Untreated)</th> <th>Alternate</th> <th>Dataset 2 (Treated)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>All Genes</td> <td>&gt; 100 residues</td> <td>All Genes</td> <td>&gt; 100 residues</td> </tr> <tr> <th>1</th> <td>A</td> <td>0.341</td> <td>0.348</td> <td>0.331</td> <td>0.338</td> </tr> <tr> <th>2</th> <td>C</td> <td>-0.052</td> <td>-0.062</td> <td>-0.045</td> <td>-0.051</td> </tr> <tr> <th>3</th> <td>D</td> <td>-0.084</td> <td>-0.083</td> <td>-0.055</td> <td>-0.057</td> </tr> <tr> <th>4</th> <td>E</td> <td>0.004</td> <td>0.016</td> <td>-0.012</td> <td>-0.004</td> </tr> <tr> <th>5</th> <td>F</td> <td>-0.072</td> <td>-0.069</td> <td>-0.057</td> <td>-0.052</td> </tr> <tr> <th>6</th> <td>G</td> <td>0.156</td> <td>0.165</td> <td>0.173</td> <td>0.184</td> </tr> <tr> <th>7</th> <td>H</td> <td>-0.075</td> <td>-0.059</td> <td>-0.064</td> <td>-0.051</td> </tr> <tr> <th>8</th> <td>I</td> <td>-0.075</td> <td>-0.085</td> <td>-0.060</td> <td>-0.071</td> </tr> <tr> <th>9</th> <td>K</td> <td>0.070</td> <td>0.062</td> <td>0.017</td> <td>0.007</td> </tr> <tr> <th>10</th> <td>L</td> <td>-0.157</td> <td>-0.155</td> <td>-0.137</td> <td>-0.131</td> </tr> <tr> <th>11</th> <td>M</td> <td>-0.046</td> <td>-0.057</td> <td>-0.053</td> <td>-0.060</td> </tr> <tr> <th>12</th> <td>N</td> <td>-0.162</td> <td>-0.156</td> <td>-0.159</td> <td>-0.158</td> </tr> <tr> <th>13</th> <td>P</td> <td>-0.026</td> <td>-0.035</td> <td>-0.006</td> <td>-0.010</td> </tr> <tr> <th>14</th> <td>Q</td> <td>-0.037</td> <td>-0.049</td> <td>-0.036</td> <td>-0.047</td> </tr> <tr> <th>15</th> <td>R</td> <td>0.018</td> <td>0.022</td> <td>-0.046</td> <td>-0.040</td> </tr> <tr> <th>16</th> <td>S</td> <td>-0.102</td> <td>-0.099</td> <td>-0.108</td> <td>-0.109</td> </tr> <tr> <th>17</th> <td>T</td> <td>0.029</td> <td>0.022</td> <td>0.041</td> <td>0.032</td> </tr> <tr> <th>18</th> <td>V</td> <td>0.178</td> <td>0.188</td> <td>0.193</td> <td>0.209</td> </tr> <tr> <th>19</th> <td>W</td> <td>-0.056</td> <td>-0.064</td> <td>-0.034</td> <td>-0.043</td> </tr> <tr> <th>20</th> <td>Y</td> <td>-0.031</td> <td>-0.040</td> <td>-0.002</td> <td>-0.009</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Amino Acid</th> <th>Correlation with log(Fold change)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>A</td> <td>-0.184</td> </tr> <tr> <th>1</th> <td>C</td> <td>0.055</td> </tr> <tr> <th>2</th> <td>D</td> <td>0.029</td> </tr> <tr> <th>3</th> <td>E</td> <td>-0.036</td> </tr> <tr> <th>4</th> <td>F</td> <td>0.136</td> </tr> <tr> <th>5</th> <td>G</td> <td>-0.118</td> </tr> <tr> <th>6</th> <td>H</td> <td>-0.014</td> </tr> <tr> <th>7</th> <td>I</td> <td>0.158</td> </tr> <tr> <th>8</th> <td>K</td> <td>-0.111</td> </tr> <tr> <th>9</th> <td>L</td> <td>0.220</td> </tr> <tr> <th>10</th> <td>M</td> <td>0.046</td> </tr> <tr> <th>11</th> <td>N</td> <td>0.143</td> </tr> <tr> <th>12</th> <td>P</td> <td>0.064</td> </tr> <tr> <th>13</th> <td>Q</td> <td>0.068</td> </tr> <tr> <th>14</th> <td>R</td> <td>-0.036</td> </tr> <tr> <th>15</th> <td>S</td> <td>-0.113</td> </tr> <tr> <th>16</th> <td>T</td> <td>-0.110</td> </tr> <tr> <th>17</th> <td>V</td> <td>-0.068</td> </tr> <tr> <th>18</th> <td>W</td> <td>0.185</td> </tr> <tr> <th>19</th> <td>Y</td> <td>0.076</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Total Samples</th> <th></th> <th>Scanty Growth</th> <th></th> <th>Semi-confluent</th> <th>growth</th> <th>Confluent</th> <th>growth</th> <th>P-value2</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Nugent's score1</td> <td>0–6</td> <td>7–10</td> <td>0–6</td> <td>7–10</td> <td>0–6</td> <td>7–10</td> <td>0–6</td> <td>7–10</td> <td></td> </tr> <tr> <th>1</th> <td>Isolate</td> <td>N</td> <td>N</td> <td>% (n)</td> <td>% (n)</td> <td>% (n)</td> <td>% (n)</td> <td>% (n)</td> <td>% (n)</td> <td></td> </tr> <tr> <th>2</th> <td>Aerobic flora</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>3</th> <td>Lactobacillus spp.</td> <td>119</td> <td>106</td> <td>5.0 (6)</td> <td>8.5 (9)</td> <td>16.8 (20)</td> <td>4.7 (5)</td> <td>33.6 (40)</td> <td>4.7 (5)</td> <td>&lt;0.001</td> </tr> <tr> <th>4</th> <td>Coliform spp.</td> <td>119</td> <td>106</td> <td>12.6 (15)</td> <td>9.4 (10)</td> <td>1.7 (2)</td> <td>6.6 (7)</td> <td>5.0 (6)</td> <td>4.7 (5)</td> <td>0.868</td> </tr> <tr> <th>5</th> <td>Staphylococcus spp.</td> <td>119</td> <td>105</td> <td>24.4 (29)</td> <td>37.1 (39)</td> <td>9.24 (11)</td> <td>4.8 (5)</td> <td>0.8 (1)</td> <td>0.9 (1)</td> <td>0.217</td> </tr> <tr> <th>6</th> <td>Streptococcus spp.</td> <td>119</td> <td>105</td> <td>13.4 (16)</td> <td>15.2 (16)</td> <td>11.8 (14)</td> <td>12.4 (13)</td> <td>13.4 (16)</td> <td>10.9 (11)</td> <td>1.000</td> </tr> <tr> <th>7</th> <td>Candida spp.</td> <td>93</td> <td>81</td> <td>11.8 (11)</td> <td>14.8 (12)</td> <td>16.1 (15)</td> <td>7.4 (6)</td> <td>15.1 (14)</td> <td>8.6 (7)</td> <td>0.117</td> </tr> <tr> <th>8</th> <td>Microaerophilic flora</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>9</th> <td>Gardnerella vaginalis</td> <td>117</td> <td>106</td> <td>1.7 (2)</td> <td>8.5 (9)</td> <td>6.8 (8)</td> <td>21.7 (23)</td> <td>13.7 (16)</td> <td>38.7 (41)</td> <td>&lt;0.001</td> </tr> <tr> <th>10</th> <td>Anaerobic flora</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>11</th> <td>Any anaerobic isolate3</td> <td>34</td> <td>32</td> <td>1 (3)</td> <td>2 (6)</td> <td>2 (6)</td> <td>9 (28)</td> <td>3 (9)</td> <td>6 (19)</td> <td>0.0054</td> </tr> <tr> <th>12</th> <td>Bacteroides spp.</td> <td>34</td> <td>32</td> <td>0</td> <td>6.2 (2)</td> <td>0</td> <td>12.5 (4)</td> <td>2.9 (1)</td> <td>12.5 (4)</td> <td>0.002</td> </tr> <tr> <th>13</th> <td>Prevotella spp.</td> <td>34</td> <td>32</td> <td>2.9 (1)</td> <td>0</td> <td>2.9 (1)</td> <td>9.4 (3)</td> <td>2.9 (1)</td> <td>12.5 (4)</td> <td>0.180</td> </tr> <tr> <th>14</th> <td>Peptostreptococcus spp.</td> <td>34</td> <td>32</td> <td>0</td> <td>0</td> <td>0</td> <td>3.1 (1)</td> <td>0</td> <td>0</td> <td>0.485</td> </tr> <tr> <th>15</th> <td>Other anaerobes5</td> <td>34</td> <td>32</td> <td>0</td> <td>0</td> <td>1 (3)</td> <td>2 (6)</td> <td>1 (3)</td> <td>0</td> <td>0.801</td> </tr> <tr> <th>16</th> <td>Mobiluncus spp.</td> <td>35</td> <td>33</td> <td>0</td> <td>0</td> <td>0</td> <td>0</td> <td>0</td> <td>0</td> <td>-</td> </tr> <tr> <th>17</th> <td>Mycoplasma hominis</td> <td>115</td> <td>105</td> <td>0</td> <td>0</td> <td>2.6 (3)</td> <td>0.9 (1)</td> <td>14.8 (17)</td> <td>24.8 (26)</td> <td>0.142</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Genital micro-organisms</th> <th>Prevalence</th> <th>of genital micro-organism</th> <th></th> <th>in those with:</th> <th></th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>No lactobacilli</td> <td></td> <td>Non H2O2</td> <td>producing lactobacilli</td> <td>H2O2 producing</td> <td>lactobacilli</td> <td>P-value1</td> </tr> <tr> <th>1</th> <td></td> <td>n/N</td> <td>(%)</td> <td>n/N</td> <td>(%)</td> <td>n/N</td> <td>(%)</td> <td></td> </tr> <tr> <th>2</th> <td>C trachomatis</td> <td>21/140</td> <td>(15.0)</td> <td>4/18</td> <td>(22.2)</td> <td>1/42</td> <td>(2.4)</td> <td>0.024</td> </tr> <tr> <th>3</th> <td>N gonorrhoeae</td> <td>12/138</td> <td>(8.7)</td> <td>0/17</td> <td>(0)</td> <td>1/42</td> <td>(2.4)</td> <td>0.303</td> </tr> <tr> <th>4</th> <td>Candida spp</td> <td>34/110</td> <td>(30.9)</td> <td>6/14</td> <td>(42.9)</td> <td>16/32</td> <td>(50.0)</td> <td>0.108</td> </tr> <tr> <th>5</th> <td>T vaginalis</td> <td>19/140</td> <td>(13.6)</td> <td>1/18</td> <td>(5.6)</td> <td>3/39</td> <td>(7.1)</td> <td>0.509</td> </tr> <tr> <th>6</th> <td>G vaginalis</td> <td>78/140</td> <td>(55.7)</td> <td>5/18</td> <td>(27.8)</td> <td>9/40</td> <td>(22.5)</td> <td>&lt;0.001</td> </tr> <tr> <th>7</th> <td>Anaerobes</td> <td>16/34</td> <td>(47.1)</td> <td>0/3</td> <td>(0)</td> <td>3/21</td> <td>(14.3)</td> <td>0.016</td> </tr> <tr> <th>8</th> <td>M hominis</td> <td>33/137</td> <td>(24.1)</td> <td>5/17</td> <td>(29.4)</td> <td>5/40</td> <td>(12.5)</td> <td>0.214</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Prevalence</th> <th>of BV (Nugent's score</th> <th>7–10)</th> <th></th> <th>Prevalence of HIV</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>n/N</td> <td>%</td> <td>P-value4</td> <td>n/N</td> <td>%</td> <td>P-value4</td> </tr> <tr> <th>1</th> <td>Douching1</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>2</th> <td>No</td> <td>12/22</td> <td>54.5</td> <td>0.507</td> <td>3/22</td> <td>13.6</td> <td>1.000</td> </tr> <tr> <th>3</th> <td>Yes</td> <td>94/202</td> <td>46.5</td> <td></td> <td>24/185</td> <td>13.0</td> <td></td> </tr> <tr> <th>4</th> <td>Menstrual hygiene</td> <td>protection method</td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>5</th> <td>Traditional2</td> <td>70/138</td> <td>50.7</td> <td>0.323</td> <td>17/129</td> <td>13.2</td> <td>1.000</td> </tr> <tr> <th>6</th> <td>Sanitary pads</td> <td>34/79</td> <td>43.0</td> <td></td> <td>9/71</td> <td>12.7</td> <td></td> </tr> <tr> <th>7</th> <td>Female genital cutting3</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>8</th> <td>No</td> <td>38/68</td> <td>55.9</td> <td>0.146</td> <td>12/63</td> <td>19.1</td> <td>0.115</td> </tr> <tr> <th>9</th> <td>Yes</td> <td>70/157</td> <td>44.6</td> <td></td> <td>15/145</td> <td>10.3</td> <td></td> </tr> <tr> <th>10</th> <td>BV</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>11</th> <td>No</td> <td></td> <td></td> <td></td> <td>12/110</td> <td>10.9</td> <td>0.414</td> </tr> <tr> <th>12</th> <td>Yes</td> <td></td> <td></td> <td></td> <td>15/100</td> <td>15.0</td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Season</th> <th>Onset</th> <th>Peak</th> <th>Offset</th> <th>Duration</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>1995/1996 late season</td> <td>1</td> <td>12</td> <td>17</td> <td>17</td> </tr> <tr> <th>1</th> <td>1996/1997 early season</td> <td>49</td> <td>8</td> <td>13</td> <td>16</td> </tr> <tr> <th>2</th> <td>1997/1998 late season</td> <td>2</td> <td>13</td> <td>20</td> <td>19</td> </tr> <tr> <th>3</th> <td>1998/1999 early season</td> <td>48</td> <td>5</td> <td>18</td> <td>24</td> </tr> <tr> <th>4</th> <td>1999/2000 late season</td> <td>50</td> <td>14</td> <td>19</td> <td>23</td> </tr> <tr> <th>5</th> <td>2000/2001 early season</td> <td>48</td> <td>6</td> <td>15</td> <td>21</td> </tr> <tr> <th>6</th> <td>2001/2002 late season</td> <td>6</td> <td>20</td> <td>23</td> <td>18</td> </tr> <tr> <th>7</th> <td>2002/2003 early season</td> <td>45</td> <td>51</td> <td>6</td> <td>14</td> </tr> <tr> <th>8</th> <td>2003/2004 late season</td> <td>1</td> <td>14</td> <td>19</td> <td>19</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Gene</th> <th>No. of Species</th> <th>TP</th> <th>TN</th> <th>FP</th> <th>FN</th> <th>Specificity</th> <th>Sensitivity</th> <th>Accuracy</th> <th>Balanced Accuracy</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Complex I</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>nad1</td> <td>10</td> <td>135</td> <td>1632</td> <td>14</td> <td>33 (2)</td> <td>99.1</td> <td>80.4 (98.5)</td> <td>97.4 (99.1)</td> <td>89.8 (98.8)</td> </tr> <tr> <th>2</th> <td>nad2</td> <td>9</td> <td>140</td> <td>2337</td> <td>22</td> <td>42 (9)</td> <td>99.1</td> <td>76.9 (94.0)</td> <td>97.5 (98.8)</td> <td>88.0 (96.5)</td> </tr> <tr> <th>3</th> <td>nad3</td> <td>22</td> <td>274</td> <td>1217</td> <td>8</td> <td>47 (4)</td> <td>99.3</td> <td>85.4 (98.6)</td> <td>96.4 (99.2)</td> <td>92.4 (99.0)</td> </tr> <tr> <th>4</th> <td>nad4</td> <td>9</td> <td>133</td> <td>2358</td> <td>19</td> <td>12 (1)</td> <td>99.2</td> <td>91.7 (99.3)</td> <td>98.8 (99.2)</td> <td>95.5 (99.2)</td> </tr> <tr> <th>5</th> <td>nad4L</td> <td>8</td> <td>49</td> <td>303</td> <td>5</td> <td>0 (0)</td> <td>98.4</td> <td>100.0 (100.0)</td> <td>98.6 (98.6)</td> <td>99.2 (99.2)</td> </tr> <tr> <th>6</th> <td>nad5</td> <td>10</td> <td>122</td> <td>3647</td> <td>29</td> <td>10 (4)</td> <td>99.2</td> <td>92.4 (96.8)</td> <td>99.0 (99.1)</td> <td>95.8 (98.0)</td> </tr> <tr> <th>7</th> <td>nad6</td> <td>10</td> <td>70</td> <td>995</td> <td>16</td> <td>15 (3)</td> <td>98.4</td> <td>82.4 (95.9)</td> <td>97.2 (98.2)</td> <td>90.4 (97.2)</td> </tr> <tr> <th>8</th> <td>nad7</td> <td>8</td> <td>117</td> <td>1655</td> <td>5</td> <td>22 (1)</td> <td>99.7</td> <td>84.2 (99.2)</td> <td>98.5 (99.7)</td> <td>91.9 (99.4)</td> </tr> <tr> <th>9</th> <td>nad9</td> <td>12</td> <td>75</td> <td>1236</td> <td>7</td> <td>5 (3)</td> <td>99.4</td> <td>93.8 (96.2)</td> <td>99.1 (99.2)</td> <td>96.6 (97.8)</td> </tr> <tr> <th>10</th> <td>Complex II</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>11</th> <td>sdh3</td> <td>7</td> <td>6</td> <td>391</td> <td>12</td> <td>11 (2)</td> <td>97.0</td> <td>35.3 (75.0)</td> <td>94.5 (96.6)</td> <td>66.2 (86.0)</td> </tr> <tr> <th>12</th> <td>sdh4</td> <td>8</td> <td>10</td> <td>361</td> <td>14</td> <td>16 (3)</td> <td>96.3</td> <td>38.5 (76.9)</td> <td>92.5 (95.6)</td> <td>67.4 (86.6)</td> </tr> <tr> <th>13</th> <td>Complex III</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>14</th> <td>cob</td> <td>13</td> <td>117</td> <td>2834</td> <td>19</td> <td>25 (8)</td> <td>99.3</td> <td>82.4 (93.6)</td> <td>98.5 (99.1)</td> <td>90.9 (96.5)</td> </tr> <tr> <th>15</th> <td>Complex IV</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>16</th> <td>cox1</td> <td>9</td> <td>38</td> <td>2936</td> <td>7</td> <td>7 (5)</td> <td>99.8</td> <td>84.4 (88.4)</td> <td>99.5 (99.6)</td> <td>92.1 (94.1)</td> </tr> <tr> <th>17</th> <td>cox2</td> <td>19</td> <td>193</td> <td>2644</td> <td>22</td> <td>33 (11)</td> <td>99.2</td> <td>85.4 (94.6)</td> <td>98.1 (98.9)</td> <td>92.3 (96.9)</td> </tr> <tr> <th>18</th> <td>cox3</td> <td>12</td> <td>80</td> <td>1793</td> <td>21</td> <td>11 (2)</td> <td>98.8</td> <td>87.9 (97.6)</td> <td>98.3 (98.8)</td> <td>93.4 (98.2)</td> </tr> <tr> <th>19</th> <td>Complex V</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>20</th> <td>atp1</td> <td>10</td> <td>21</td> <td>2926</td> <td>10</td> <td>8 (1)</td> <td>99.7</td> <td>72.4 (95.5)</td> <td>99.4 (99.6)</td> <td>86.0 (97.6)</td> </tr> <tr> <th>21</th> <td>atp4</td> <td>7</td> <td>51</td> <td>730</td> <td>21</td> <td>18 (8)</td> <td>97.2</td> <td>73.9 (86.4)</td> <td>95.2 (96.4)</td> <td>85.6 (91.8)</td> </tr> <tr> <th>22</th> <td>atp6</td> <td>12</td> <td>88</td> <td>1893</td> <td>11</td> <td>10 (2)</td> <td>99.4</td> <td>89.8 (97.8)</td> <td>99.0 (99.3)</td> <td>94.6 (98.6)</td> </tr> <tr> <th>23</th> <td>atp8</td> <td>8</td> <td>16</td> <td>757</td> <td>10</td> <td>10 (2)</td> <td>98.7</td> <td>61.5 (88.9)</td> <td>97.5 (98.5)</td> <td>80.1 (93.8)</td> </tr> <tr> <th>24</th> <td>atp9</td> <td>19</td> <td>91</td> <td>792</td> <td>1</td> <td>17 (0)</td> <td>99.9</td> <td>84.3 (100.0)</td> <td>98.0 (99.9)</td> <td>92.1 (99.9)</td> </tr> <tr> <th>25</th> <td>Cytochrome</td> <td>c biogenesis</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>26</th> <td>ccmB</td> <td>9</td> <td>216</td> <td>1013</td> <td>14</td> <td>63 (6)</td> <td>98.6</td> <td>77.4 (97.3)</td> <td>94.1 (98.4)</td> <td>88.0 (98.0)</td> </tr> <tr> <th>27</th> <td>ccmC</td> <td>9</td> <td>187</td> <td>1212</td> <td>24</td> <td>26 (1)</td> <td>98.1</td> <td>87.8 (99.5)</td> <td>96.5 (98.2)</td> <td>92.9 (98.8)</td> </tr> <tr> <th>28</th> <td>ccmFc</td> <td>6</td> <td>84</td> <td>1631</td> <td>23</td> <td>30 (10)</td> <td>98.6</td> <td>73.7 (89.4)</td> <td>97.0 (98.1)</td> <td>86.1 (94.0)</td> </tr> <tr> <th>29</th> <td>ccmFn</td> <td>6</td> <td>155</td> <td>2249</td> <td>39</td> <td>38 (21)</td> <td>98.3</td> <td>80.3 (88.1)</td> <td>96.9 (97.6)</td> <td>89.3 (93.2)</td> </tr> <tr> <th>30</th> <td>Ribosomal proteins</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>31</th> <td>rpl2</td> <td>4</td> <td>2</td> <td>1057</td> <td>14</td> <td>6 (4)</td> <td>98.7</td> <td>25.0 (33.3)</td> <td>98.1 (98.3)</td> <td>61.8 (66.0)</td> </tr> <tr> <th>32</th> <td>rpl5</td> <td>9</td> <td>45</td> <td>919</td> <td>14</td> <td>5 (3)</td> <td>98.5</td> <td>90.0</td> <td>98.1 (98.3)</td> <td>94.2 (96.1)</td> </tr> <tr> <th>33</th> <td>rpl6</td> <td>3</td> <td>0</td> <td>138</td> <td>3</td> <td>0 (0)</td> <td>97.9</td> <td>-</td> <td>97.9 (97.9)</td> <td>-</td> </tr> <tr> <th>34</th> <td>rpl16</td> <td>9</td> <td>33</td> <td>692</td> <td>6</td> <td>13 (2)</td> <td>99.1</td> <td>71.7 (94.3)</td> <td>97.4 (98.9)</td> <td>85.4 (96.7)</td> </tr> <tr> <th>35</th> <td>rps1</td> <td>3</td> <td>2</td> <td>295</td> <td>4</td> <td>5 (5)</td> <td>98.7</td> <td>28.6 (28.6)</td> <td>97.1 (97.1)</td> <td>63.6 (63.6)</td> </tr> <tr> <th>36</th> <td>rps2</td> <td>7</td> <td>25</td> <td>1489</td> <td>15</td> <td>7 (5)</td> <td>99.0</td> <td>78.1 (83.3)</td> <td>98.6 (98.7)</td> <td>88.6 (91.2)</td> </tr> <tr> <th>37</th> <td>rps3</td> <td>7</td> <td>54</td> <td>2183</td> <td>19</td> <td>33 (11)</td> <td>99.1</td> <td>62.1 (83.1)</td> <td>97.7 (98.7)</td> <td>80.6 (91.1)</td> </tr> <tr> <th>38</th> <td>rps4</td> <td>6</td> <td>83</td> <td>1116</td> <td>22</td> <td>18 (6)</td> <td>98.1</td> <td>82.2 (93.3)</td> <td>96.8 (97.7)</td> <td>90.1 (95.7)</td> </tr> <tr> <th>39</th> <td>rps7</td> <td>8</td> <td>6</td> <td>664</td> <td>19</td> <td>2 (1)</td> <td>97.2</td> <td>75.0 (85.7)</td> <td>97.0 (97.1)</td> <td>86.1 (91.5)</td> </tr> <tr> <th>40</th> <td>rps10</td> <td>5</td> <td>8</td> <td>266</td> <td>9</td> <td>0 (0)</td> <td>96.7</td> <td>100.0 (100.0)</td> <td>96.8 (96.8)</td> <td>98.4 (98.4)</td> </tr> <tr> <th>41</th> <td>rps11</td> <td>3</td> <td>0</td> <td>222</td> <td>1</td> <td>0 (0)</td> <td>99.6</td> <td>-</td> <td>99.6 (99.6)</td> <td>-</td> </tr> <tr> <th>42</th> <td>rps12</td> <td>17</td> <td>87</td> <td>1142</td> <td>13</td> <td>5 (1)</td> <td>98.9</td> <td>94.6 (98.9)</td> <td>98.6 (98.9)</td> <td>96.7 (98.9)</td> </tr> <tr> <th>43</th> <td>rps13</td> <td>10</td> <td>34</td> <td>554</td> <td>8</td> <td>5 (2)</td> <td>98.6</td> <td>87.2 (94.4)</td> <td>97.8 (98.3)</td> <td>92.9 (96.5)</td> </tr> <tr> <th>44</th> <td>rps14</td> <td>5</td> <td>2</td> <td>239</td> <td>7</td> <td>0 (0)</td> <td>97.2</td> <td>100.0 (100.0)</td> <td>(97.2) (97.2)</td> <td>98.6 (98.6)</td> </tr> <tr> <th>45</th> <td>rps19</td> <td>6</td> <td>16</td> <td>242</td> <td>11</td> <td>9 (3)</td> <td>95.7</td> <td>64.0 (84.2)</td> <td>92.8 (94.9)</td> <td>79.8 (89.9)</td> </tr> <tr> <th>46</th> <td>Other</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>47</th> <td>matR</td> <td>8</td> <td>73</td> <td>4109</td> <td>30</td> <td>20 (7)</td> <td>99.3</td> <td>78.5 (91.3)</td> <td>98.8 (99.1)</td> <td>88.9 (95.3)</td> </tr> <tr> <th>48</th> <td>mttB</td> <td>8</td> <td>100</td> <td>1087</td> <td>41</td> <td>23 (12)</td> <td>96.4</td> <td>81.3 (89.3)</td> <td>94.9 (95.7)</td> <td>88.8 (92.8)</td> </tr> <tr> <th>49</th> <td>Overall</td> <td>370</td> <td>3,038</td> <td>55,956</td> <td>609</td> <td>660 (171)</td> <td>98.9</td> <td>82.2 (94.7)</td> <td>97.9 (98.7)</td> <td>90.5 (96.8)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Gene</th> <th>Species</th> <th>TP</th> <th>FP</th> <th>FN</th> <th>Score</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>atp1</td> <td>Secale cereale</td> <td>0</td> <td>5</td> <td>1 (0)</td> <td>0.96</td> </tr> <tr> <th>1</th> <td>cox3</td> <td>Oryza sativa</td> <td>1</td> <td>13</td> <td>0 (0)</td> <td>0.93</td> </tr> <tr> <th>2</th> <td>rpl2</td> <td>Arabidopsis thaliana</td> <td>0</td> <td>3</td> <td>1 (0)</td> <td>0.78</td> </tr> <tr> <th>3</th> <td>four rpl2</td> <td>Brassica napus</td> <td>1</td> <td>3</td> <td>1 (0)</td> <td>0.78</td> </tr> <tr> <th>4</th> <td>rpl2</td> <td>Oenothera berteriana</td> <td>1</td> <td>5</td> <td>3 (3)</td> <td>0.67</td> </tr> <tr> <th>5</th> <td>rpl2</td> <td>Oryza sativa</td> <td>0</td> <td>3</td> <td>1 (1)</td> <td>0.67</td> </tr> <tr> <th>6</th> <td>rps1</td> <td>Oenothera berteriana</td> <td>0</td> <td>3</td> <td>0 (0)</td> <td>1.00</td> </tr> <tr> <th>7</th> <td>rps7</td> <td>Arabidopsis thaliana</td> <td>0</td> <td>2</td> <td>0 (0)</td> <td>0.93</td> </tr> <tr> <th>8</th> <td>rps12</td> <td>Oryza sativa</td> <td>0</td> <td>6</td> <td>0 (0)</td> <td>0.95</td> </tr> <tr> <th>9</th> <td>of rps14</td> <td>Brassica napus</td> <td>0</td> <td>3</td> <td>0 (0)</td> <td>0.67</td> </tr> <tr> <th>10</th> <td>sdh4</td> <td>Gymnocladus dioica</td> <td>0</td> <td>4</td> <td>0 (0)</td> <td>0.68</td> </tr> <tr> <th>11</th> <td>sdh4</td> <td>Podophyllum peltatum</td> <td>1</td> <td>4</td> <td>4 (0)</td> <td>0.68</td> </tr> <tr> <th>12</th> <td>Overall</td> <td></td> <td>4</td> <td>54</td> <td>11 (4)</td> <td>0.83</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Mantoux</th> <th>Children</th> <th>Evaluation</th> <th>of scar formation</th> <th>[n (%)]</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Induration (mm)</td> <td>n</td> <td>Real scar (&gt;2 mm)</td> <td>Tiny scar (≤ 2 mm)</td> <td>No scar (?)</td> </tr> <tr> <th>1</th> <td>Negative (0–3,9)</td> <td>43</td> <td>17 (39.5)*</td> <td>20 (46.5)**,***</td> <td>6 (14)***,***</td> </tr> <tr> <th>2</th> <td>Weak positive (4–5,9)</td> <td>45</td> <td>32 (71.1)</td> <td>13 (28.9)**,***</td> <td>0 (0)***,***</td> </tr> <tr> <th>3</th> <td>Positive (&gt;6)</td> <td>1036</td> <td>1030 (99.4)*</td> <td>6 (0.6)***,***</td> <td>0 (0)***,***</td> </tr> <tr> <th>4</th> <td>Total</td> <td>1124</td> <td>1079 (96.0)</td> <td>39 (3.5)</td> <td>6 (0.5)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Method</th> <th>ref1</th> <th>ref2</th> <th>ref3</th> <th>Total</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>DIALIGN-T</td> <td>82.28%</td> <td>78.36%</td> <td>79.71%</td> <td>80.12%</td> </tr> <tr> <th>1</th> <td>DIALIGN 2.2</td> <td>79.46%</td> <td>77.82%</td> <td>78.24%</td> <td>78.51%</td> </tr> <tr> <th>2</th> <td>T-COFFEE 1.37</td> <td>75.35%</td> <td>66.60%</td> <td>69.21%</td> <td>70.19%</td> </tr> <tr> <th>3</th> <td>PROBCONS 1.09</td> <td>33.13%</td> <td>37.95%</td> <td>51.26%</td> <td>40.78%</td> </tr> <tr> <th>4</th> <td>POA V2</td> <td>73.00%</td> <td>12.46%</td> <td>07.45%</td> <td>30.97%</td> </tr> <tr> <th>5</th> <td>MUSCLE 3.5</td> <td>09.41%</td> <td>10.89%</td> <td>22.37%</td> <td>14.22%</td> </tr> <tr> <th>6</th> <td>CLUSTAL W 1.83</td> <td>00.00%</td> <td>00.83%</td> <td>05.14%</td> <td>01.92%</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Method</th> <th>ref1</th> <th>ref2</th> <th>ref3</th> <th>ref4</th> <th>ref5</th> <th>Total</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>DIALIGN-T</td> <td>82.76%</td> <td>91.28%</td> <td>75.34%</td> <td>86.43%</td> <td>93.30%</td> <td>84.69%</td> </tr> <tr> <th>1</th> <td>DIALIGN 2.2</td> <td>81.40%</td> <td>89.56%</td> <td>68.93%</td> <td>91.24%</td> <td>94.14%</td> <td>83.59%</td> </tr> <tr> <th>2</th> <td>T-COFFEE 1.37</td> <td>84.67%</td> <td>93.24%</td> <td>80.32%</td> <td>75.80%</td> <td>96.20%</td> <td>85.95%</td> </tr> <tr> <th>3</th> <td>PROBCONS 1.09</td> <td>90.37%</td> <td>94.61%</td> <td>84.34%</td> <td>89.20%</td> <td>98.07%</td> <td>91.11%</td> </tr> <tr> <th>4</th> <td>POA V2</td> <td>74.66%</td> <td>88.32%</td> <td>63.14%</td> <td>82.62%</td> <td>76.71%</td> <td>76.76%</td> </tr> <tr> <th>5</th> <td>MUSCLE 3.5</td> <td>88.25%</td> <td>93.59%</td> <td>82.36%</td> <td>85.62%</td> <td>97.80%</td> <td>89.21%</td> </tr> <tr> <th>6</th> <td>CLUSTAL W 1.83</td> <td>86.43%</td> <td>93.22%</td> <td>75.79%</td> <td>81.09%</td> <td>86.10%</td> <td>86.15%</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Method</th> <th>ref1</th> <th>ref2</th> <th>ref3</th> <th>Total</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>DIALIGN 2.2</td> <td>20.00%+</td> <td>23.33%0</td> <td>23.33%+</td> <td>22.22%+</td> </tr> <tr> <th>1</th> <td>T-COFFEE 1.37</td> <td>40.00%0</td> <td>31.67%+</td> <td>41.67%+</td> <td>37.78%+</td> </tr> <tr> <th>2</th> <td>PROBCONS 1.09</td> <td>20.00%+</td> <td>15.00%+</td> <td>21.67%+</td> <td>18.89%+</td> </tr> <tr> <th>3</th> <td>POA V2</td> <td>16.67%+</td> <td>0.00%+</td> <td>0.00%+</td> <td>5.55%+</td> </tr> <tr> <th>4</th> <td>MUSCLE 3.5</td> <td>5.00%+</td> <td>5.00%+</td> <td>0.00%+</td> <td>3.33%+</td> </tr> <tr> <th>5</th> <td>CLUSTAL W 1.83</td> <td>0.00%+</td> <td>0.00%0</td> <td>0.00%0</td> <td>0.0%+</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Method</th> <th>ref1</th> <th>ref2</th> <th>ref3</th> <th>Total</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>DIALIGN 2.2</td> <td>11.67%+</td> <td>21.67%0</td> <td>23.33%+</td> <td>18.89%+</td> </tr> <tr> <th>1</th> <td>T-COFFEE 1.37</td> <td>36.67%0</td> <td>30.00%+</td> <td>26.67%+</td> <td>31.11%+</td> </tr> <tr> <th>2</th> <td>PROBCONS 1.09</td> <td>18.33%+</td> <td>01.67%+</td> <td>16.67%+</td> <td>16.67%+</td> </tr> <tr> <th>3</th> <td>POA V2</td> <td>15.00%+</td> <td>00.00%+</td> <td>00.00%+</td> <td>05.00%+</td> </tr> <tr> <th>4</th> <td>MUSCLE 3.5</td> <td>05.00%+</td> <td>05.00%+</td> <td>00.00%+</td> <td>03.33%+</td> </tr> <tr> <th>5</th> <td>CLUSTAL W 1.83</td> <td>00.00%+</td> <td>00.00%+</td> <td>00.00%+</td> <td>00.00%+</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Pfam</th> <th>Type</th> <th>SCOP</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>DHH</td> <td>Family</td> <td>c.107.1.1; c.107.1.2</td> </tr> <tr> <th>1</th> <td>OsmC</td> <td>Family</td> <td>d.227.1.2; d.227.1.1</td> </tr> <tr> <th>2</th> <td>Pec_lyase_C</td> <td>Domain</td> <td>b.80.1.2; b.80.1.1</td> </tr> <tr> <th>3</th> <td>Glyoxalase</td> <td>Domain</td> <td>d.32.1.3; d.32.1.1; d.32.1.4; d.32.1.2</td> </tr> <tr> <th>4</th> <td>TOBE</td> <td>Domain</td> <td>b.40.6.1; b.40.6.3; b.40.6.2</td> </tr> <tr> <th>5</th> <td>HhH-GPD</td> <td>Domain</td> <td>a.96.1.2; a.96.1.3; a.96.1.1</td> </tr> <tr> <th>6</th> <td>NAD_binding_1</td> <td>Domain</td> <td>c.25.1.4; c.25.1.1; c.25.1.5; c.25.1.2</td> </tr> <tr> <th>7</th> <td>Glyco_hydro_15</td> <td>Family</td> <td>a.102.1.1; a.102.1.5</td> </tr> <tr> <th>8</th> <td>Ricin_B_lectin</td> <td>Repeat</td> <td>b.42.2.1; b.42.2.2</td> </tr> <tr> <th>9</th> <td>Prenyltrans</td> <td>Repeat</td> <td>a.102.4.3; a.102.4.2</td> </tr> <tr> <th>10</th> <td>HHH</td> <td>Motif</td> <td>a.60.2.1; a.60.4.1; a.60.2.3; a.60.2.2</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th colspan="2" halign="left"></th> </tr> <tr> <th></th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Signs and symptoms of HF</td> <td>Effort dyspnoea, Hortopnoea, III-IV tones, Pulmonary rales</td> </tr> <tr> <th>1</th> <td>Normal or mildly reduced LV systolic function</td> <td>EF ≥ 45 % e LVIDDi &gt; 3.2 cm·m -2</td> </tr> <tr> <th>2</th> <td>Evidence of abnormalities LV of relaxation/filling and/or distensibility</td> <td>IVRT &lt;30 years &gt; 92 ms, 30–50 years &gt; 100 ms, &gt;50 years &gt; 105 msc E/A&lt;1 + DT&gt;220 ms + S/D&lt;1.5 &lt;50 years E/A&lt;0.5 + DT&gt;280 msec + S/S&gt;2.5 &gt;-50 years</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Event</th> <th>Happened to</th> <th>Me</th> <th>Happened to Someone</th> <th>I Know Well</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Number</td> <td>%</td> <td>Number</td> <td>%</td> </tr> <tr> <th>1</th> <td>Badly bitten by a dog or another animal</td> <td>8</td> <td>13.8</td> <td>15</td> <td>25.9</td> </tr> <tr> <th>2</th> <td>Badly scared or hurt by a gang or criminal</td> <td>4</td> <td>6.9</td> <td>17</td> <td>29.3</td> </tr> <tr> <th>3</th> <td>Badly beaten</td> <td>1</td> <td>1.7</td> <td>14</td> <td>24.1</td> </tr> <tr> <th>4</th> <td>Shot or stabbed</td> <td>0</td> <td>0</td> <td>16</td> <td>27.6</td> </tr> <tr> <th>5</th> <td>Terrible fire or explosion</td> <td>0</td> <td>0</td> <td>7</td> <td>12.1</td> </tr> <tr> <th>6</th> <td>Chemical or other deadly poisoning</td> <td>1</td> <td>1.7</td> <td>4</td> <td>6.9</td> </tr> <tr> <th>7</th> <td>Bad storm, flood, tornado, hurricane or earthquake</td> <td>2</td> <td>3.4</td> <td>6</td> <td>10.3</td> </tr> <tr> <th>8</th> <td>Bad car, boat, bike, train, or plane accident</td> <td>3</td> <td>5.2</td> <td>18</td> <td>31</td> </tr> <tr> <th>9</th> <td>Other very bad accident</td> <td>5</td> <td>8.6</td> <td>9</td> <td>15.5</td> </tr> <tr> <th>10</th> <td>Got sick and almost died or died</td> <td>5</td> <td>8.6</td> <td>28</td> <td>48.3</td> </tr> <tr> <th>11</th> <td>Kidnapped or held captive</td> <td>0</td> <td>0</td> <td>5</td> <td>8.6</td> </tr> <tr> <th>12</th> <td>Suicide attempt or died from suicide</td> <td>4</td> <td>6.9</td> <td>19</td> <td>32.8</td> </tr> <tr> <th>13</th> <td>I was taken away from my family</td> <td>1</td> <td>1.7</td> <td></td> <td></td> </tr> <tr> <th>14</th> <td>I saw something terrible happen to a stranger</td> <td>16</td> <td>27.6</td> <td></td> <td></td> </tr> <tr> <th>15</th> <td>Other shocking or terrifying event</td> <td>5</td> <td>8.6</td> <td>2</td> <td>3.4</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Rate of PTSD symptoms on the K-SADS</th> <th></th> <th>Rate of PTSD symptoms on the CATS</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>symptom</td> <td>%</td> <td>symptom</td> <td>%</td> </tr> <tr> <th>1</th> <td></td> <td>Comparable</td> <td>Symptoms</td> <td></td> </tr> <tr> <th>2</th> <td>Recurrent thoughts or images of events</td> <td>28</td> <td>I go over and over what happened in my mind</td> <td>40</td> </tr> <tr> <th>3</th> <td>Efforts to avoid thoughts or images associated with the trauma</td> <td>28</td> <td>I try not to think about what happened</td> <td>47</td> </tr> <tr> <th>4</th> <td>Insomnia</td> <td>22</td> <td>I sleep poorly</td> <td>26</td> </tr> <tr> <th>5</th> <td>Irritability or outbursts of anger</td> <td>24</td> <td>I am grouch and irritable</td> <td>36</td> </tr> <tr> <th>6</th> <td>Distress at reminders of event</td> <td>16</td> <td>When something reminds me of what happened I get tense and upset</td> <td>21</td> </tr> <tr> <th>7</th> <td>Exaggerated startle response</td> <td>17</td> <td>I am jumpy and nervous</td> <td>29</td> </tr> <tr> <th>8</th> <td>Nightmares</td> <td>16</td> <td>I have bad dreams about what happened</td> <td>9</td> </tr> <tr> <th>9</th> <td>Difficulty concentrating</td> <td>19</td> <td>I have trouble keeping my mind on things</td> <td>28</td> </tr> <tr> <th>10</th> <td>Efforts to avoid activities or situations that arouse recollections of the trauma</td> <td>21</td> <td>I try to stay away from things that remind me of what happened</td> <td>21</td> </tr> <tr> <th>11</th> <td></td> <td>Non-comparable</td> <td>Symptoms</td> <td></td> </tr> <tr> <th>12</th> <td>Sense of foreshortened future</td> <td>3</td> <td>I worry that what happened will happen again</td> <td>57</td> </tr> <tr> <th>13</th> <td>Feelings of detachment or estrangement</td> <td>21</td> <td>I get scared when I think about what happened</td> <td>38</td> </tr> <tr> <th>14</th> <td>Inability to recall important aspects of the trauma</td> <td>10</td> <td>I have unwanted thoughts about what happened</td> <td>21</td> </tr> <tr> <th>15</th> <td>Restricted affect</td> <td>28</td> <td></td> <td></td> </tr> <tr> <th>16</th> <td>Hypervigilance</td> <td>17</td> <td></td> <td></td> </tr> <tr> <th>17</th> <td>Physiological reactivity upon exposure to reminders</td> <td>9</td> <td></td> <td></td> </tr> <tr> <th>18</th> <td>Dissociative episodes, illusions or hallucinations</td> <td>21</td> <td></td> <td></td> </tr> <tr> <th>19</th> <td>Diminished interest in activities</td> <td>22</td> <td></td> <td></td> </tr> <tr> <th>20</th> <td>Repetitive play related to event / reenactment</td> <td>2</td> <td></td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>PTSD Symptom</th> <th></th> <th></th> <th></th> <th>95% Confidence</th> <th>Interval</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>Observed Kappa</td> <td>Standard Error</td> <td>Lower Limit</td> <td>Upper Limit</td> </tr> <tr> <th>1</th> <td>Recurrent thoughts or images of event</td> <td>(i)</td> <td>0.02</td> <td>0.14</td> <td>-0.31</td> <td>0.26</td> </tr> <tr> <th>2</th> <td></td> <td>(ii)</td> <td>-0.57</td> <td>0.22</td> <td>-1.01</td> <td>-0.13</td> </tr> <tr> <th>3</th> <td></td> <td>(iii)</td> <td>0.01</td> <td>0.18</td> <td>-0.33</td> <td>0.35</td> </tr> <tr> <th>4</th> <td>Trying not to think about the event</td> <td>(i)</td> <td>0.25</td> <td>0.13</td> <td>-0.003</td> <td>0.51</td> </tr> <tr> <th>5</th> <td></td> <td>(ii)</td> <td>-0.14</td> <td>0.56</td> <td>-1.24</td> <td>0.96</td> </tr> <tr> <th>6</th> <td></td> <td>(iii)</td> <td>0.07</td> <td>0.17</td> <td>-0.26</td> <td>0.41</td> </tr> <tr> <th>7</th> <td>Sleep problems</td> <td>(i)</td> <td>0.44</td> <td>0.15</td> <td>0.15</td> <td>0.72</td> </tr> <tr> <th>8</th> <td></td> <td>(ii)</td> <td>0.61</td> <td>0.25</td> <td>0.11</td> <td>1</td> </tr> <tr> <th>9</th> <td></td> <td>(iii)</td> <td>0.16</td> <td>0.23</td> <td>-0.3</td> <td>0.62</td> </tr> <tr> <th>10</th> <td>Anger and irritability</td> <td>(i)</td> <td>0.24</td> <td>0.14</td> <td>-0.05</td> <td>0.52</td> </tr> <tr> <th>11</th> <td></td> <td>(ii)</td> <td>0.24</td> <td>0.3</td> <td>-0.35</td> <td>0.83</td> </tr> <tr> <th>12</th> <td></td> <td>(iii)</td> <td>0.13</td> <td>0.19</td> <td>-0.24</td> <td>0.49</td> </tr> <tr> <th>13</th> <td>Distress at reminders of event</td> <td>(i)</td> <td>0.48</td> <td>0.16</td> <td>0.17</td> <td>0.79</td> </tr> <tr> <th>14</th> <td></td> <td>(ii)</td> <td>0.44</td> <td>0.28</td> <td>-0.1</td> <td>0.98</td> </tr> <tr> <th>15</th> <td></td> <td>(iii)</td> <td>0.17</td> <td>0.29</td> <td>-0.4</td> <td>0.74</td> </tr> <tr> <th>16</th> <td>Exaggerated startle response</td> <td>(i)</td> <td>0.39</td> <td>0.15</td> <td>0.09</td> <td>0.68</td> </tr> <tr> <th>17</th> <td></td> <td>(ii)</td> <td>0.3</td> <td>0.35</td> <td>-0.38</td> <td>0.98</td> </tr> <tr> <th>18</th> <td></td> <td>(iii)</td> <td>0</td> <td>0.3</td> <td>-0.59</td> <td>0.59</td> </tr> <tr> <th>19</th> <td>Nightmares</td> <td>(i)</td> <td>0.2</td> <td>0.23</td> <td>-0.26</td> <td>0.65</td> </tr> <tr> <th>20</th> <td></td> <td>(ii)</td> <td>0.23</td> <td>0.26</td> <td>-0.28</td> <td>0.73</td> </tr> <tr> <th>21</th> <td></td> <td>(iii)</td> <td>-0.05</td> <td>0.45</td> <td>-0.93</td> <td>0.82</td> </tr> <tr> <th>22</th> <td>Difficulty concentrating</td> <td>(i)</td> <td>0.19</td> <td>0.17</td> <td>-0.04</td> <td>0.51</td> </tr> <tr> <th>23</th> <td></td> <td>(ii)</td> <td>0.35</td> <td>0.26</td> <td>-0.15</td> <td>0.86</td> </tr> <tr> <th>24</th> <td></td> <td>(iii)</td> <td>0.03</td> <td>0.23</td> <td>-0.41</td> <td>0.48</td> </tr> <tr> <th>25</th> <td>Efforts to avoid reminders of event</td> <td>(i)</td> <td>0.27</td> <td>0.15</td> <td>-0.03</td> <td>0.56</td> </tr> <tr> <th>26</th> <td></td> <td>(ii)</td> <td>-0.31</td> <td>0.3</td> <td>-0.89</td> <td>0.28</td> </tr> <tr> <th>27</th> <td></td> <td>(iii)</td> <td>0.34</td> <td>0.18</td> <td>-0.02</td> <td>0.7</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Interested</th> <th>Non-interested</th> <th>OR (95% CI)1)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>(n = 225)</td> <td>(n = 553)</td> <td></td> </tr> <tr> <th>1</th> <td></td> <td>%</td> <td>%</td> <td></td> </tr> <tr> <th>2</th> <td>Physician visit in past year</td> <td>76</td> <td>68</td> <td>1.53 (1.06–2.20)</td> </tr> <tr> <th>3</th> <td>Gynaecologist visit in past year</td> <td>53</td> <td>39</td> <td>1.40 (1.01–1.94)</td> </tr> <tr> <th>4</th> <td>Used calcium drugs in last 2 weeks</td> <td>32</td> <td>23</td> <td>1.49 (1.04–2.13)</td> </tr> <tr> <th>5</th> <td>Used PHT at some time 2)</td> <td>26</td> <td>11</td> <td>2.62 (1.58–4.35)</td> </tr> <tr> <th>6</th> <td>Used PHT at some time 3)</td> <td>16</td> <td>8</td> <td>2.05 (1.26–3.35)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Complication</th> <th>Patients (n)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Pin site infection grade 2 [13]</td> <td>5</td> </tr> <tr> <th>1</th> <td>Loose pin at removal of fixator/pins</td> <td>6</td> </tr> <tr> <th>2</th> <td>Septic arthritis</td> <td>1</td> </tr> <tr> <th>3</th> <td>Deep venous thrombosis</td> <td>2</td> </tr> <tr> <th>4</th> <td>Loss of correction</td> <td>1</td> </tr> <tr> <th>5</th> <td>Pseudoarthrosis</td> <td>1</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th></th> <th></th> <th>Univeriate analysis</th> <th></th> <th></th> <th>Multivariate</th> <th>analysisII</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Predictor Variable</td> <td>Na</td> <td>Cb</td> <td>(95% CI)</td> <td>pc</td> <td>R2 adjd</td> <td>Cb</td> <td>(95% CI)</td> <td>pc</td> </tr> <tr> <th>1</th> <td>Age (year)</td> <td>52</td> <td>0.27</td> <td>(-0.62–1.17)</td> <td>0.54</td> <td>0%</td> <td></td> <td>Not included</td> <td></td> </tr> <tr> <th>2</th> <td>BMI (kg/m2)</td> <td>48</td> <td>0.62</td> <td>(-0.89–2.12)</td> <td>0.41</td> <td>0%</td> <td></td> <td>Not included</td> <td></td> </tr> <tr> <th>3</th> <td>Preop pain (0–100)</td> <td>52</td> <td>'-0.61</td> <td>(-0.92–-0.29)</td> <td>0.0003</td> <td>21%</td> <td>'-0.6</td> <td>(-0.9–-0.2,8)</td> <td>0.0004</td> </tr> <tr> <th>4</th> <td>Sex</td> <td>52</td> <td>1.42</td> <td>(-10.77–13.6)</td> <td>0.82</td> <td>0%</td> <td></td> <td>Not included</td> <td></td> </tr> <tr> <th>5</th> <td>0: female</td> <td>26</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>6</th> <td>1: male</td> <td>26</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>7</th> <td>Acceptable 2 year HKA-angle</td> <td>42</td> <td>8.78</td> <td>(-12.81–30.38)</td> <td>0.41</td> <td>0%</td> <td></td> <td>Not included</td> <td></td> </tr> <tr> <th>8</th> <td>0: no</td> <td>7</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>9</th> <td>1: yes</td> <td>37</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>10</th> <td>Smoker</td> <td>52</td> <td>'-0.35</td> <td>(-15.27–14.56)</td> <td>0.96</td> <td>0%</td> <td></td> <td>Not included</td> <td></td> </tr> <tr> <th>11</th> <td>0: no</td> <td>40</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>12</th> <td>1: yes</td> <td>12</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>13</th> <td>Complication</td> <td>51</td> <td>'-15.8</td> <td>(-16.6–7.94)</td> <td>0.06</td> <td>0.5%</td> <td>'-14.7</td> <td>(-29.4–0.08)</td> <td>0.05</td> </tr> <tr> <th>14</th> <td>0: no</td> <td>43</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>15</th> <td>1: yes</td> <td>8</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Characteristics</th> <th></th> <th></th> <th>Income Quintile</th> <th></th> <th></th> <th>P-value</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>1</td> <td>2</td> <td>3</td> <td>4</td> <td>5</td> <td></td> </tr> <tr> <th>1</th> <td></td> <td>N = 15057</td> <td>N = 14655</td> <td>N = 12268</td> <td>N = 10310</td> <td>N = 8167</td> <td></td> </tr> <tr> <th>2</th> <td>Neighborhood Income ($)</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>0.0039</td> </tr> <tr> <th>3</th> <td>Median</td> <td>16433</td> <td>18572</td> <td>20256</td> <td>22982</td> <td>26786</td> <td></td> </tr> <tr> <th>4</th> <td>Interquartile Range</td> <td>15408–16988</td> <td>18056–19201</td> <td>20043–21020</td> <td>22186–24258</td> <td>25899–29710</td> <td></td> </tr> <tr> <th>5</th> <td>Mean Age (yr)</td> <td>78.03+/- 7.65</td> <td>77.94+/- 7.55</td> <td>78.07+/- 7.59</td> <td>78.29+/- 7.58</td> <td>78.51+/- 7.72</td> <td>0.0370</td> </tr> <tr> <th>6</th> <td>Female sex (%)</td> <td>47.23</td> <td>48.29</td> <td>47.21</td> <td>49.20</td> <td>49.44</td> <td>0.0007</td> </tr> <tr> <th>7</th> <td>Comorbid conditions (%)</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>8</th> <td>Chronic Lung Disease</td> <td>6.91</td> <td>7.55</td> <td>6.33</td> <td>7.59</td> <td>6.61</td> <td>0.5382</td> </tr> <tr> <th>9</th> <td>Congestive Heart Failure</td> <td>4.30</td> <td>4.79</td> <td>4.73</td> <td>4.76</td> <td>3.87</td> <td>0.4348</td> </tr> <tr> <th>10</th> <td>Ischemic Heart Disease</td> <td>11.60</td> <td>12.90</td> <td>14.11</td> <td>14.31</td> <td>13.22</td> <td>&lt;0.0001</td> </tr> <tr> <th>11</th> <td>Peripheral Vascular Disease</td> <td>1.34</td> <td>1.30</td> <td>1.36</td> <td>1.26</td> <td>1.04</td> <td>0.1003</td> </tr> <tr> <th>12</th> <td>Chronic Renal Failure</td> <td>0.90</td> <td>0.87</td> <td>1.04</td> <td>1.09</td> <td>0.73</td> <td>0.9210</td> </tr> <tr> <th>13</th> <td>Diabetes</td> <td>6.97</td> <td>8.02</td> <td>7.44</td> <td>7.38</td> <td>6.09</td> <td>0.0199</td> </tr> <tr> <th>14</th> <td>Cancer</td> <td>2.89</td> <td>3.43</td> <td>3.73</td> <td>3.77</td> <td>4.04</td> <td>&lt;0.0001</td> </tr> <tr> <th>15</th> <td>Charlson score &gt; 1 (%)</td> <td>28.76</td> <td>28.98</td> <td>30.91</td> <td>31.74</td> <td>31.50</td> <td>&lt;0.0001</td> </tr> <tr> <th>16</th> <td>Specialty of Attending Physician (%):</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>&lt;0.0001</td> </tr> <tr> <th>17</th> <td>General Practice</td> <td>54.78</td> <td>62.27</td> <td>56.26</td> <td>43.96</td> <td>42.07</td> <td></td> </tr> <tr> <th>18</th> <td>Internal Medicine</td> <td>26.69</td> <td>23.82</td> <td>26.18</td> <td>34.24</td> <td>35.14</td> <td></td> </tr> <tr> <th>19</th> <td>Respirology</td> <td>6.16</td> <td>5.43</td> <td>5.98</td> <td>7.19</td> <td>8.90</td> <td></td> </tr> <tr> <th>20</th> <td>Other</td> <td>12.37</td> <td>8.47</td> <td>11.57</td> <td>14.62</td> <td>13.89</td> <td></td> </tr> <tr> <th>21</th> <td>Teaching Hospital (%)</td> <td>17.63</td> <td>11.31</td> <td>17.12</td> <td>23.66</td> <td>23.58</td> <td>&lt;0.0001</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Outcome/Treatment N (%)</th> <th>Income Quintile</th> <th></th> <th></th> <th></th> <th></th> <th>P-value</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>1</td> <td>2</td> <td>3</td> <td>4</td> <td>5</td> <td></td> </tr> <tr> <th>1</th> <td></td> <td>N = 15057</td> <td>N = 14655</td> <td>N = 12268</td> <td>N = 10310</td> <td>N = 8167</td> <td></td> </tr> <tr> <th>2</th> <td>Length of Stay</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>0.1448</td> </tr> <tr> <th>3</th> <td>Mean +/- SD (days)</td> <td>9.41 +/- 13.0</td> <td>8.95 +/- 12.5</td> <td>9.54 +/- 13.9</td> <td>9.59 +/- 14.0</td> <td>9.96 +/- 14.0</td> <td></td> </tr> <tr> <th>4</th> <td>Median (Interquartile Range)</td> <td>6 (4–10)</td> <td>6 (4–10)</td> <td>6 (4–10)</td> <td>6 (4–10)</td> <td>6 (4–11)</td> <td></td> </tr> <tr> <th>5</th> <td>Acute Length of Stay</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>0.2362</td> </tr> <tr> <th>6</th> <td>Mean +/- SD (days)</td> <td>8.39 +/- 8.52</td> <td>7.93 +/- 7.58</td> <td>8.29 +/- 8.12</td> <td>8.37 +/- 8.44</td> <td>8.86 +/- 9.60</td> <td></td> </tr> <tr> <th>7</th> <td>Median (Interquartile Range)</td> <td>6 (4–10)</td> <td>6 (4–10)</td> <td>6 (4–10)</td> <td>6 (4–10)</td> <td>6 (4–11)</td> <td></td> </tr> <tr> <th>8</th> <td>Discharge Destination</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td>&lt;0.0001</td> </tr> <tr> <th>9</th> <td>Acute Care Hospital</td> <td>433 (2.88)</td> <td>284 (1.94)</td> <td>224 (1.83)</td> <td>128 (1.24)</td> <td>99 (1.21)</td> <td></td> </tr> <tr> <th>10</th> <td>Chronic Care Hospital</td> <td>263 (1.75)</td> <td>365 (2.49)</td> <td>285 (2.32)</td> <td>211 (2.05)</td> <td>140 (1.71)</td> <td></td> </tr> <tr> <th>11</th> <td>Rehabilitation Hospital</td> <td>57 (0.38)</td> <td>106 (0.72)</td> <td>92 (0.75)</td> <td>102 (0.99)</td> <td>93 (1.14)</td> <td></td> </tr> <tr> <th>12</th> <td>Nursing Home</td> <td>361 (2.40)</td> <td>289 (1.97)</td> <td>229 (1.87)</td> <td>187 (1.81)</td> <td>174 (2.13)</td> <td></td> </tr> <tr> <th>13</th> <td>Home Care Program</td> <td>2101 (13.95)</td> <td>1890 (12.90)</td> <td>1754 (14.30)</td> <td>1561 (15.14)</td> <td>1123 (13.75)</td> <td></td> </tr> <tr> <th>14</th> <td>Home</td> <td>11648 (77.36)</td> <td>11484 (78.36)</td> <td>9511 (77.53)</td> <td>7998 (77.58)</td> <td>6455 (79.04)</td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Season correlated with malaria cases in 1800–1870</th> <th></th> <th>Source of temperature</th> <th>series</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Helsinki 1830–1870 41 years</td> <td>Tornedalen 1818–1870 53 years</td> <td>Stockholm 1800–1870 71 years</td> <td>St. Petersburg 1806–1870 65 years</td> </tr> <tr> <th>1</th> <td>malaria year-1; winter</td> <td>-0.1932</td> <td>-0.1209</td> <td>-0.1652</td> <td>-0.0789</td> </tr> <tr> <th>2</th> <td>malaria year-1; spring</td> <td>-0.0091</td> <td>-0.0228</td> <td>0.0248</td> <td>-0.0312</td> </tr> <tr> <th>3</th> <td>malaria year-1; summer</td> <td>0.5120 ***</td> <td>0.5208 ***</td> <td>0.4708 ***</td> <td>0.3981 ***</td> </tr> <tr> <th>4</th> <td>malaria year-1; autumn</td> <td>0.1218</td> <td>0.1621</td> <td>0.1055</td> <td>0.1598</td> </tr> <tr> <th>5</th> <td>malaria year; winter</td> <td>-0.1254</td> <td>-0.0743</td> <td>-0.1214</td> <td>-0.1543</td> </tr> <tr> <th>6</th> <td>malaria year; spring</td> <td>0.1140</td> <td>0.0880</td> <td>0.0223</td> <td>0.0546</td> </tr> <tr> <th>7</th> <td>malaria year; summer</td> <td>-0.0740</td> <td>-0.0332</td> <td>0.0201</td> <td>-0.0439</td> </tr> <tr> <th>8</th> <td>malaria year; autumn</td> <td>-0.0831</td> <td>-0.0819</td> <td>-0.0211</td> <td>-0.0797</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Month of preceding year correlated with malaria cases in 1800–1870</th> <th></th> <th>Source of temperature</th> <th>series</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Helsinki 1830–1870 41 years</td> <td>Tornedalen 1818–1870 53 years</td> <td>Stockholm 1800–1870 71 years</td> <td>St. Petersburg 1806–1870 65 years</td> </tr> <tr> <th>1</th> <td>malaria year-1; May</td> <td>0.1487</td> <td>0.0269</td> <td>0.0511</td> <td>0.1338</td> </tr> <tr> <th>2</th> <td>malaria year-1; June</td> <td>0.4301 **</td> <td>0.5289 ***</td> <td>0.3372 **</td> <td>0.3587 **</td> </tr> <tr> <th>3</th> <td>malaria year-1; July</td> <td>0.4628 **</td> <td>0.4135 **</td> <td>0.4543 ***</td> <td>0.2888 *</td> </tr> <tr> <th>4</th> <td>malaria year-1; August</td> <td>0.2672°</td> <td>0.1570</td> <td>0.2740 *</td> <td>0.1793</td> </tr> <tr> <th>5</th> <td>malaria year-1; September</td> <td>0.1156</td> <td>0.0655</td> <td>0.0637</td> <td>0.0678</td> </tr> <tr> <th>6</th> <td>malaria year-1; October</td> <td>0.1566</td> <td>0.0200</td> <td>0.1326</td> <td>0.2657 *</td> </tr> <tr> <th>7</th> <td>malaria year-1; November</td> <td>0.1462</td> <td>0.1958</td> <td>0.0000</td> <td>0.0220</td> </tr> <tr> <th>8</th> <td>malaria year-1; December</td> <td>0.0037</td> <td>-0.002</td> <td>-0.1144</td> <td>-0.1221</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Tortoise no.</th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th>Nucleotide</th> <th></th> <th></th> <th>position</th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th>Origin</th> <th>12S haplotype</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td></td> <td></td> <td></td> <td>1</td> <td>1</td> <td>1</td> <td>1</td> <td>2</td> <td>2</td> <td>2</td> <td>2</td> <td>2</td> <td>2</td> <td>3</td> <td>3</td> <td>3</td> <td>3</td> <td>3</td> <td>3</td> <td></td> <td></td> </tr> <tr> <th>1</th> <td></td> <td>4</td> <td>4</td> <td>5</td> <td>9</td> <td>1</td> <td>7</td> <td>7</td> <td>9</td> <td>0</td> <td>0</td> <td>3</td> <td>4</td> <td>5</td> <td>9</td> <td>1</td> <td>1</td> <td>2</td> <td>3</td> <td>7</td> <td>7</td> <td></td> <td></td> </tr> <tr> <th>2</th> <td></td> <td>8</td> <td>9</td> <td>8</td> <td>9</td> <td>3</td> <td>0</td> <td>4</td> <td>3</td> <td>1</td> <td>8</td> <td>6</td> <td>4</td> <td>8</td> <td>4</td> <td>3</td> <td>6</td> <td>2</td> <td>2</td> <td>5</td> <td>7</td> <td></td> <td></td> </tr> <tr> <th>3</th> <td>TGKL</td> <td>T</td> <td>T</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Morocco (Al-Hoceima)</td> <td>Tg1.0</td> </tr> <tr> <th>4</th> <td>703888</td> <td>T</td> <td>T</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Tunisia</td> <td>Tg1.0</td> </tr> <tr> <th>5</th> <td>704089</td> <td>T</td> <td>T</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Morocco</td> <td>Tg1.0</td> </tr> <tr> <th>6</th> <td>SNA1</td> <td>T</td> <td>T</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Algeria</td> <td>Tg1.0</td> </tr> <tr> <th>7</th> <td>TGG0042</td> <td>A</td> <td>C</td> <td>-</td> <td>T</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Tunisia (Sibkur)</td> <td>Tg2.0</td> </tr> <tr> <th>8</th> <td>TGG0043</td> <td>A</td> <td>C</td> <td>-</td> <td>T</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Tunisia (Sibkur)</td> <td>Tg2.0</td> </tr> <tr> <th>9</th> <td>TGG0041</td> <td>A</td> <td>C</td> <td>-</td> <td>T</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>Tunisia</td> <td>Tg2.0</td> </tr> <tr> <th>10</th> <td>A2SN</td> <td>A</td> <td>C</td> <td>-</td> <td>T</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>G</td> <td>G</td> <td>C</td> <td>Algeria</td> <td>Tg2.0</td> </tr> <tr> <th>11</th> <td>TGGLY1</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>?</td> <td>Tg3.0</td> </tr> <tr> <th>12</th> <td>TGLKX</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>A</td> <td>A</td> <td>G</td> <td>C</td> <td>?</td> <td>Tg3.1</td> </tr> <tr> <th>13</th> <td>TGLM1</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>Morocco (Laroche)</td> <td>Tg5.1</td> </tr> <tr> <th>14</th> <td>TGLM2</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>Morocco (Laroche)</td> <td>Tg4.2</td> </tr> <tr> <th>15</th> <td>703157</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>?</td> <td>Tg4.1</td> </tr> <tr> <th>16</th> <td>TGTURBO</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>?</td> <td>Tg5.0</td> </tr> <tr> <th>17</th> <td>F1621</td> <td>A</td> <td>C</td> <td>T</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>Lebanon</td> <td>Tg6.0</td> </tr> <tr> <th>18</th> <td>HZTGIAN</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>C</td> <td>South-Turkey</td> <td>Tg6.0</td> </tr> <tr> <th>19</th> <td>TGRW5</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>G</td> <td>T</td> <td>Israel (Hasharon Park)</td> <td>Tg6.0</td> </tr> <tr> <th>20</th> <td>TGRW4</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>T</td> <td>Israel (Golan Heights)</td> <td>Tg6.0</td> </tr> <tr> <th>21</th> <td>TGRW1</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>T</td> <td>Israel (Petah Tiqwa)</td> <td>Tg6.0</td> </tr> <tr> <th>22</th> <td>TGRW3</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>T</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>A</td> <td>T</td> <td>Israel (Golan Heights)</td> <td>Tg6.0</td> </tr> <tr> <th>23</th> <td>TGRW2</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>T</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>A</td> <td>T</td> <td>A</td> <td>A</td> <td>G</td> <td>T</td> <td>Israel (Petah Tiqwa)</td> <td>Tg6.0</td> </tr> <tr> <th>24</th> <td>703837</td> <td>A</td> <td>C</td> <td>-</td> <td>C</td> <td>C</td> <td>C</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>G</td> <td>G</td> <td>A</td> <td>A</td> <td>A</td> <td>T</td> <td>G</td> <td>A</td> <td>G</td> <td>C</td> <td>?</td> <td>Tg7.0</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>A.</th> <th>HPV</th> <th>cLIA time</th> <th>(weeks)</th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>HPV type</td> <td>0</td> <td>2</td> <td>4</td> <td>8</td> <td>10</td> <td>12</td> <td>16</td> <td>20</td> <td>24</td> <td>26</td> <td>28</td> <td>52</td> </tr> <tr> <th>1</th> <td>HPV 6</td> <td>1.1</td> <td>3.2</td> <td>2.4</td> <td>4.3</td> <td>10.0</td> <td>12.6</td> <td>36.3</td> <td>10.9</td> <td>6.3</td> <td>22.7</td> <td>41.9</td> <td>4.3</td> </tr> <tr> <th>2</th> <td>HPV 11</td> <td>0.8</td> <td>2.9</td> <td>2.2</td> <td>5.5</td> <td>23.5</td> <td>18.1</td> <td>16.2</td> <td>8.2</td> <td>6.1</td> <td>18.4</td> <td>36.8</td> <td>5.3</td> </tr> <tr> <th>3</th> <td>HPV 16</td> <td>1.0</td> <td>5.2</td> <td>8.8</td> <td>8.4</td> <td>21.4</td> <td>15.7</td> <td>16.1</td> <td>11.4</td> <td>17.7</td> <td>4.8</td> <td>12.7</td> <td>6.4</td> </tr> <tr> <th>4</th> <td>HPV 18</td> <td>1.0</td> <td>4.8</td> <td>13.7</td> <td>19.4</td> <td>70.5</td> <td>18.6</td> <td>27.1</td> <td>35.4</td> <td>26.3</td> <td>6.7</td> <td>26.8</td> <td>26.7</td> </tr> <tr> <th>5</th> <td>B.</td> <td>HPV</td> <td>Total IgG</td> <td>antibodies</td> <td>time</td> <td>(weeks)</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>6</th> <td>HPV type</td> <td>0</td> <td>2</td> <td>4</td> <td>8</td> <td>10</td> <td>12</td> <td>16</td> <td>20</td> <td>24</td> <td>26</td> <td>28</td> <td>52</td> </tr> <tr> <th>7</th> <td>HPV 6</td> <td>1.9</td> <td>9.5</td> <td>9.5</td> <td>13.1</td> <td>125.0</td> <td>328.3</td> <td>125.0</td> <td>65.7</td> <td>34.4</td> <td>34.5</td> <td>65.7</td> <td>18.1</td> </tr> <tr> <th>8</th> <td>HPV 11</td> <td>1.9</td> <td>13.1</td> <td>25.0</td> <td>25.0</td> <td>125.0</td> <td>90.6</td> <td>125.0</td> <td>47.6</td> <td>34.5</td> <td>34.5</td> <td>90.6</td> <td>18.1</td> </tr> <tr> <th>9</th> <td>HPV 16</td> <td>0.9</td> <td>5.0</td> <td>9.5</td> <td>6.9</td> <td>65.7</td> <td>65.7</td> <td>90.6</td> <td>65.7</td> <td>13.1</td> <td>13.1</td> <td>65.7</td> <td>25.0</td> </tr> <tr> <th>10</th> <td>HPV 18</td> <td>0.7</td> <td>9.5</td> <td>13.1</td> <td>25.0</td> <td>125.0</td> <td>47.6</td> <td>65.7</td> <td>65.7</td> <td>25.0</td> <td>47.6</td> <td>125.0</td> <td>90.6</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Index</th> <th>N</th> <th>Groups</th> <th></th> <th>P &lt; :</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>Control (+/+)</td> <td>Diabetes (db/db)</td> <td></td> </tr> <tr> <th>1</th> <td>Body Weight (g)</td> <td>5</td> <td>21 ± 3</td> <td>47 ± 5</td> <td>0.001</td> </tr> <tr> <th>2</th> <td>Blood Glucose (mg/dl)</td> <td>5</td> <td>103 ± 8</td> <td>428 ± 16</td> <td>0.001</td> </tr> <tr> <th>3</th> <td>Uterine Weight (mg)</td> <td>5</td> <td>44 ± 3</td> <td>13 ± 4</td> <td>0.01</td> </tr> <tr> <th>4</th> <td>Serum Triglycerides (mg/ ml)</td> <td>5</td> <td>143 ± 8</td> <td>312 ± 24</td> <td>0.001</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Source of E. coli</th> <th>Lambda</th> <th>M13</th> <th>P1</th> <th>øX174</th> <th>T4</th> <th>T7</th> <th>none</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Mouse feces and GI tracts (n = 22)</td> <td>0 (0%)</td> <td>0 (0%)</td> <td>8 (36%)</td> <td>3 (14%)</td> <td>4 (18%)</td> <td>3 (14%)</td> <td>13 (59%)</td> </tr> <tr> <th>1</th> <td>Human clinical specimens (n=15)</td> <td>1 (7%)</td> <td>1 (7%)</td> <td>6 (40%)</td> <td>1 (7%)</td> <td>1 (7%)</td> <td>2 (13%)</td> <td>7 (47%)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Study Group</th> <th>No.</th> <th>11</th> <th>12</th> <th>22</th> <th>12 + 22</th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>n (%)</td> <td>n (%)</td> <td>n (%)</td> <td>n (%)</td> <td>p valuea</td> <td>ORb (95% CI)</td> </tr> <tr> <th>1</th> <td>Control</td> <td>256</td> <td>112 (43.8)</td> <td>115 (44.9)</td> <td>29 (11.3)</td> <td>144 (56.2)</td> <td></td> <td></td> </tr> <tr> <th>2</th> <td>All Breast Cancer</td> <td>352</td> <td>164 (46.6)</td> <td>150 (42.6)</td> <td>38 (10.8)</td> <td>188 (53.4)</td> <td>0.51</td> <td>0.89 (0.64–1.23)</td> </tr> <tr> <th>3</th> <td>Diagnosis ≤ 40 years</td> <td>203</td> <td>104 (51.2)</td> <td>79 (38.9)</td> <td>20 (9.9)</td> <td>99 (48.8)</td> <td>0.13</td> <td>0.74 (0.51–1.07</td> </tr> <tr> <th>4</th> <td>Family History</td> <td>105</td> <td>39 (37.1)</td> <td>53 (50.5)</td> <td>13 (12.4)</td> <td>66 (62.9)</td> <td>0.29</td> <td>1.32 (0.83–2.10)</td> </tr> <tr> <th>5</th> <td>Bilateral Disease</td> <td>44</td> <td>21 (47.7)</td> <td>18 (40.9)</td> <td>5 (11.4)</td> <td>23 (52.3)</td> <td>0.63</td> <td>0.85 (0.45–1.62)</td> </tr> <tr> <th>6</th> <td>All Ovarian Tumours</td> <td>390</td> <td>202 (51.8)</td> <td>153 (39.2)</td> <td>35 (9.0)</td> <td>188 (48.2)</td> <td>0.05</td> <td>0.72 (0.53–0.99)</td> </tr> <tr> <th>7</th> <td>All Malignant</td> <td>313</td> <td>157 (50.2)</td> <td>126 (40.2)</td> <td>30 (9.6)</td> <td>156 (49.8)</td> <td>0.13</td> <td>0.77 (0.55–1.08)</td> </tr> <tr> <th>8</th> <td>Serous</td> <td>127</td> <td>62 (48.8)</td> <td>52 (40.9)</td> <td>13 (10.2)</td> <td>65 (51.1)</td> <td>0.38</td> <td>0.81 (0.53–1.25)</td> </tr> <tr> <th>9</th> <td>Endometrioid</td> <td>82</td> <td>44 (53.6)</td> <td>29 (35.4)</td> <td>9 (11.0)</td> <td>38 (46.4)</td> <td>0.13</td> <td>0.67 (0.41–1.11)</td> </tr> <tr> <th>10</th> <td>Mucinous</td> <td>42</td> <td>23 (54.8)</td> <td>16 (38.1)</td> <td>3 (7.1)</td> <td>19 (45.2)</td> <td>0.24</td> <td>0.64 (0.33–1.24)</td> </tr> <tr> <th>11</th> <td>Clear Cell</td> <td>13</td> <td>4 (30.8)</td> <td>8 (61.5)</td> <td>1 (7.7)</td> <td>9 (69.2)</td> <td>0.40</td> <td>1.75 (0.52–5.83)</td> </tr> <tr> <th>12</th> <td>Adenocarcinoma</td> <td>49</td> <td>24 (49.0)</td> <td>21 (42.8)</td> <td>4 (8.2)</td> <td>25 (51.0)</td> <td>0.53</td> <td>0.81 (0.44–1.49)</td> </tr> <tr> <th>13</th> <td>Borderline</td> <td>15</td> <td>6 (40.0)</td> <td>8 (53.3)</td> <td>1 (6.7)</td> <td>9 (60.0)</td> <td>1.00</td> <td>1.16 (0.40–3.37)</td> </tr> <tr> <th>14</th> <td>Benign</td> <td>62</td> <td>39 (62.9)</td> <td>19 (30.6)</td> <td>4 (6.4)</td> <td>23 (37.0)</td> <td>0.007</td> <td>0.46 (0.26–0.81)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Functional type</th> <th>Fluffy tails (F&gt;2)</th> <th>No fluffy tails (F&lt;2)</th> <th>Positive rate</th> <th>Negative rate</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Regulatory regions</td> <td>51</td> <td>9</td> <td>85 %</td> <td>15 %</td> </tr> <tr> <th>1</th> <td>Exons</td> <td>1</td> <td>59</td> <td>1.6 %</td> <td>98.4 %</td> </tr> <tr> <th>2</th> <td>Non-coding presumed non- regulatory</td> <td>10</td> <td>50</td> <td>16 %</td> <td>84 %</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Arabidopsis thaliana</th> <th>Haemophilus influenzae</th> <th>Helicobacter pylori 26695</th> <th>Helicobacter pylori J99</th> <th>Homo sapien</th> <th>Saccharomyces cerevisiae</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Total Hits In Genome</td> <td>30,056</td> <td>1077</td> <td>81</td> <td>119</td> <td>67,881</td> <td>4027</td> </tr> <tr> <th>1</th> <td>Hits With 'Phosphatase' Present In Annotation</td> <td>267</td> <td>1</td> <td>0</td> <td>0</td> <td>535</td> <td>51</td> </tr> <tr> <th>2</th> <td>Percentage Of Hits With 'Phosphatase' Where Hit Is In Promoter (3000 Base Pairs Upstream)</td> <td>53.9</td> <td>100</td> <td>0</td> <td>0</td> <td>28.8</td> <td>52.9</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>14,349 Unique NCBI One Term Windows</th> <th>18,934 Unique NCBI Two Term Windows</th> <th>24,747 Unique NCBI Three Term Windows</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>GO Term Equality</td> <td>16,001</td> <td>9096</td> <td>4313</td> </tr> <tr> <th>1</th> <td>GO Term Similarity</td> <td>16,001</td> <td>9096</td> <td>4313</td> </tr> <tr> <th>2</th> <td>GO Phrase Similarity</td> <td>19,137,006</td> <td>228,624</td> <td>28,556</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Characteristics</th> <th>Stage I</th> <th>Stage II</th> <th>Stage III</th> <th>Stage IV</th> <th>P value</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Age at Cohort Entrance</td> <td>14.3 ± 2.3</td> <td>15.4 ± 2.9</td> <td>15.2 ± 2.6</td> <td>16</td> <td>.06</td> </tr> <tr> <th>1</th> <td>Caucasian</td> <td>3</td> <td>9</td> <td>10</td> <td>1</td> <td>.73</td> </tr> <tr> <th>2</th> <td>African American</td> <td>1</td> <td>2</td> <td>2</td> <td>0</td> <td>.35</td> </tr> <tr> <th>3</th> <td>STD's</td> <td>0</td> <td>2</td> <td>2</td> <td>0</td> <td>.50</td> </tr> <tr> <th>4</th> <td>Contraception Use</td> <td>1</td> <td>4</td> <td>4</td> <td>1</td> <td>.08</td> </tr> <tr> <th>5</th> <td>Desire for Conception</td> <td>3</td> <td>9</td> <td>10</td> <td>-</td> <td>.73</td> </tr> <tr> <th>6</th> <td>Male Partner's Evaluation</td> <td>0</td> <td>1</td> <td>1</td> <td>-</td> <td>.12</td> </tr> <tr> <th>7</th> <td>Other Therapies Used</td> <td>1</td> <td>2</td> <td>3</td> <td>-</td> <td>.25</td> </tr> <tr> <th>8</th> <td>Age at Stage of Endometriosis</td> <td>15.2 ± 2.1</td> <td>16.8 ± 2.7</td> <td>16.7 ± 2.3</td> <td>16.9</td> <td>.535</td> </tr> <tr> <th>9</th> <td>Time Trying to Conceive (Month)</td> <td>15.1 ± 4.5</td> <td>12.8 ± 3.8</td> <td>13.1 ± 4.2</td> <td>-</td> <td>.310</td> </tr> <tr> <th>10</th> <td>Age at Follow-up</td> <td>22.3 ± 5.4</td> <td>24.7 ± 4.6</td> <td>25.3 ± 4.9</td> <td>-</td> <td>.125</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Level of clinical suspicion</th> <th>Ultrasound</th> <th>No Ultrasound</th> <th>Risk ratio for harm (95% CI)</th> <th>Risk ratio for benefit (95% CI)</th> <th>Odds ratio (95% CI)</th> <th>Risk difference (95% CI)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>All</td> <td>21/314 (7%)</td> <td>25/315 (8%)</td> <td>0.84 (0.48 to 1.47)</td> <td>1.01 (0.97 to 1.06)</td> <td>0.83 (0.46 to 1.52)</td> <td>-0.01 (-0.05 to 0.03)</td> </tr> <tr> <th>1</th> <td>Strong</td> <td>7/95 (7%)</td> <td>11/89 (12%)</td> <td>0.60 (0.24 to 1.47)</td> <td>1.06 (0.96 to 1.16)</td> <td>0.56 (0.21 to 1.53)</td> <td>-0.05 (-0.14 to 0.04)</td> </tr> <tr> <th>2</th> <td>Moderate</td> <td>14/219 (6%)</td> <td>14/226 (6%)</td> <td>1.03 (0.50 to 2.11)</td> <td>1.00 (0.95 to 1.05)</td> <td>1.03 (0.48 to 2.22)</td> <td>0.00 (-0.04 to 0.05)</td> </tr> <tr> <th>3</th> <td>Test of interaction1</td> <td></td> <td></td> <td>P = 0.35</td> <td>P = 0.29</td> <td>P = 0.34</td> <td>P = 0.30</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>PSZ threshold</th> <th># phylogenetic motifs</th> <th># sequences</th> </tr> </thead> <tbody> <tr> <th>0</th> <td># phylogenetic motifs</td> <td>0.15</td> <td></td> <td></td> </tr> <tr> <th>1</th> <td># sequences</td> <td>0.08</td> <td>-0.07</td> <td></td> </tr> <tr> <th>2</th> <td>MSA length</td> <td>-0.32</td> <td>0.68</td> <td>0.00</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Protein family</th> <th>PDB ID</th> <th>Correct</th> <th>Useful info</th> <th>Wrong</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>A. Proteins from Table 1</td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Acetyglucosamine-6-phoshate deacyetylaseb</td> <td>1O12</td> <td>6</td> <td>1</td> <td>0</td> </tr> <tr> <th>2</th> <td>Alcohol dehydrogenase</td> <td>1JVB</td> <td>2</td> <td>1</td> <td>1</td> </tr> <tr> <th>3</th> <td>CuZnSOD</td> <td>1SPD</td> <td>3</td> <td>2</td> <td>1</td> </tr> <tr> <th>4</th> <td>Cytochrome P450</td> <td>1N4G</td> <td>6</td> <td>4</td> <td>0</td> </tr> <tr> <th>5</th> <td>Enolase</td> <td>2ONE</td> <td>6</td> <td>2</td> <td>0</td> </tr> <tr> <th>6</th> <td>Glyceroladhyde-3-phosphate dehydrogenase</td> <td>1DC4</td> <td>2</td> <td>2</td> <td>3</td> </tr> <tr> <th>7</th> <td>Glycerol kinase</td> <td>1B05</td> <td>7</td> <td>1</td> <td>0</td> </tr> <tr> <th>8</th> <td>Glutamate dehydrogenase</td> <td>1HWZ</td> <td>7</td> <td>0</td> <td>0</td> </tr> <tr> <th>9</th> <td>Inorganic pyrophosphatase</td> <td>1I6T</td> <td>3</td> <td>2</td> <td>0</td> </tr> <tr> <th>10</th> <td>Myoglobin</td> <td>1MBA</td> <td>4</td> <td>1</td> <td>0</td> </tr> <tr> <th>11</th> <td>Succinate dehydrogenase – FAD</td> <td>1NEK</td> <td>4</td> <td>1</td> <td>2</td> </tr> <tr> <th>12</th> <td>Succinate dehydrogenase – Fe/S</td> <td>1NEK</td> <td>4</td> <td>0</td> <td>0</td> </tr> <tr> <th>13</th> <td>Succinate dehydrogenase – Heme</td> <td>1NEK</td> <td>5</td> <td>0</td> <td>0</td> </tr> <tr> <th>14</th> <td>TATA box binding protein</td> <td>1TBP</td> <td>n/ac</td> <td></td> <td></td> </tr> <tr> <th>15</th> <td>Triosephosphate isomerase</td> <td>7TIM</td> <td>3</td> <td>4</td> <td>1</td> </tr> <tr> <th>16</th> <td>B. Additional examples</td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>17</th> <td>Acetate kinase</td> <td>1G99</td> <td>4</td> <td>4</td> <td>0</td> </tr> <tr> <th>18</th> <td>Aconitase A</td> <td>7ACN</td> <td>8</td> <td>3</td> <td>5</td> </tr> <tr> <th>19</th> <td>Alanine racemase</td> <td>1L6F</td> <td>4</td> <td>1</td> <td>1</td> </tr> <tr> <th>20</th> <td>Arginyl-tRNA synthetase</td> <td>1F7U</td> <td>2</td> <td>2</td> <td>1</td> </tr> <tr> <th>21</th> <td>Biotin carboxylaseb</td> <td>1DV2</td> <td>3</td> <td>3</td> <td>2</td> </tr> <tr> <th>22</th> <td>Catalase</td> <td>1GGF</td> <td>9</td> <td>0</td> <td>0</td> </tr> <tr> <th>23</th> <td>Citrate synthase</td> <td>1NXG</td> <td>8</td> <td>1</td> <td>0</td> </tr> <tr> <th>24</th> <td>Isocitrate dehydrogenases</td> <td>1IA2</td> <td>3</td> <td>0</td> <td>0</td> </tr> <tr> <th>25</th> <td>Malate/lactate dehydrogenases</td> <td>1EMD</td> <td>6</td> <td>1</td> <td>0</td> </tr> <tr> <th>26</th> <td>Malate synthase</td> <td>1P7T</td> <td>6</td> <td>0</td> <td>0</td> </tr> <tr> <th>27</th> <td>Phosphomannomutase</td> <td>1P5D</td> <td>5</td> <td>2</td> <td>0</td> </tr> <tr> <th>28</th> <td>Selenocysteine lyase</td> <td>1ECX</td> <td>5</td> <td>2</td> <td>1</td> </tr> <tr> <th>29</th> <td>Threonine aldolase</td> <td>1LW5</td> <td>6</td> <td>2</td> <td>0</td> </tr> <tr> <th>30</th> <td>Thymidylate synthase</td> <td>1AIQ</td> <td>4</td> <td>0</td> <td>1</td> </tr> <tr> <th>31</th> <td>Transaldolase</td> <td>1ONR</td> <td>1</td> <td>1</td> <td>1</td> </tr> <tr> <th>32</th> <td>Trehalose-6-phosphate synthase</td> <td>1UQU</td> <td>5</td> <td>3</td> <td>3</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Age of the patienta</th> <th>Detected pathogenic microbial strain(s)</th> <th>Antimicrobial agent(s) used</th> <th>Special remarks</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>11 months</td> <td>E. coli (group C)</td> <td>Trimethoprim and sulphamethoxazole</td> <td>Severe diarrhea and vomiting, metabolic acidosis, hospitalization and i.v. rehydration required</td> </tr> <tr> <th>1</th> <td>21 months (1 y. 9 mo.)</td> <td>E. coli (group C)</td> <td>Cefuroxime</td> <td>Initially applied trimethoprim and sulphamethoxazole did not give a therapeutic effect</td> </tr> <tr> <th>2</th> <td>27 months (2 y. 3 mo.)</td> <td>E. coli (group A)</td> <td>Nifuroxazide</td> <td>None</td> </tr> <tr> <th>3</th> <td>28 months (2 y. 4 mo.)</td> <td>P. aeruginosa</td> <td>None</td> <td>Tablets containing Lactobacillus rhamnosus were used to normalize intestinal flora</td> </tr> <tr> <th>4</th> <td>29 months (2 y. 5 mo.)</td> <td>E. coli (group C)</td> <td>Furazidin</td> <td>None</td> </tr> <tr> <th>5</th> <td>45 months (3 y. 9 mo.)</td> <td>Adenoviruses, C. albicans (in addition, H. parainfluenzae, S. viridans and Neiserria sp. were isolated from oral cavity)</td> <td>Cefuroxime, fluconazole, trimethoprim and sulphamethoxazole</td> <td>Very severe diarrhea and vomiting, severe dehydration and electrolyte depletion, metabolic acidosis, severe stomatitis. Hospitalization and parenteral nutrition required</td> </tr> <tr> <th>6</th> <td>49 months (4 y. 1 mo.)</td> <td>Adenoviruses</td> <td>None</td> <td>None</td> </tr> <tr> <th>7</th> <td>50 months (4 y. 2 mo.)</td> <td>E. coli (group C)</td> <td>Furazidin, trimethoprim and sulphamethoxazole</td> <td>Severe diarrhea, hospitalization and i.v. rehydration required</td> </tr> <tr> <th>8</th> <td>54 months (4 y. 6 mo.)</td> <td>Adenoviruses</td> <td>None</td> <td>None</td> </tr> <tr> <th>9</th> <td>55 months (4 y. 7 mo.)</td> <td>E. coli (group C)</td> <td>Furazidin</td> <td>None</td> </tr> <tr> <th>10</th> <td>56 months (4 y. 8 mo.)</td> <td>E. coli (group C), S. aureus, C. albicans</td> <td>Furazidin, fluconazole</td> <td>None</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Threshold of clinical benefit that would make offering</th> <th>PDT as a treatment worthwhile</th> <th></th> <th>Survey</th> <th>year</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>2000</td> <td>2001</td> <td>2002</td> <td>2003</td> </tr> <tr> <th>1</th> <td>To prevent the loss of 3 lines of visual acuity over 2 years</td> <td>At least In 1 person for every 7 treated</td> <td>22 (19%)</td> <td>31 (27%)</td> <td>30 (28%)</td> <td>36 (37%)</td> </tr> <tr> <th>2</th> <td></td> <td>In 1 person for every 4 treated</td> <td>35 (30%)</td> <td>37 (32%)</td> <td>38 (35%)</td> <td>34 (35%)</td> </tr> <tr> <th>3</th> <td></td> <td>In 1 person for every 2 treated</td> <td>21 (18%)</td> <td>27 (23%)</td> <td>20 (19%)</td> <td>16 (17%)</td> </tr> <tr> <th>4</th> <td>Further evidence of effectiveness required</td> <td></td> <td>39 (33%)</td> <td>20 (19%)</td> <td>20 (17%)</td> <td>11 (11%)</td> </tr> <tr> <th>5</th> <td>Total</td> <td></td> <td>117</td> <td>108</td> <td>115</td> <td>97</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Dependent variable</th> <th>Independent variables</th> <th>β</th> <th>R</th> <th>R2</th> <th>Adjusted R2</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Attitude concerning the use of PDT</td> <td>Social pressure from local colleagues</td> <td>-0.38**</td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td></td> <td>Social pressure from the RCO</td> <td>-0.03</td> <td></td> <td></td> <td></td> </tr> <tr> <th>2</th> <td></td> <td>Social pressure from NICE</td> <td>-0.05</td> <td></td> <td></td> <td></td> </tr> <tr> <th>3</th> <td></td> <td>Social pressure from other ophthalmologists</td> <td>-0.14</td> <td></td> <td></td> <td></td> </tr> <tr> <th>4</th> <td></td> <td></td> <td></td> <td>0.51***</td> <td>0.26</td> <td>0.22</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Characteristic</th> <th></th> <th></th> <th>Genotype</th> <th>[n (%)]</th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>CYP2D6*1/*1</td> <td>CYP2D6*1/*4</td> <td>CYP2D6*4/*4</td> <td>SULT1A1*1/*1</td> <td>SULT1A1*1/*2</td> <td>SULT1A1*2/*2</td> </tr> <tr> <th>1</th> <td>Nodal involvementa, tumour</td> <td>size</td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>2</th> <td>Node-, &gt;30 mm</td> <td>19 (76.0)</td> <td>5 (20.0)</td> <td>1 (4.0)</td> <td>6 (24.0)</td> <td>11 (44.0)</td> <td>8 (32.0)</td> </tr> <tr> <th>3</th> <td>Node+, ≤ 20 mm</td> <td>66 (74.2)</td> <td>18 (20.2)</td> <td>5 (5.6)</td> <td>30 (33.7)</td> <td>49 (55.1)</td> <td>10 (11.2)</td> </tr> <tr> <th>4</th> <td>Node+, &gt;20 mm</td> <td>77 (68.8)</td> <td>32 (28.6)</td> <td>3 (2.7)</td> <td>43 (38.4)</td> <td>59 (52.7)</td> <td>10 (8.9)</td> </tr> <tr> <th>5</th> <td>Receptor statusb</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>6</th> <td>ER-negative</td> <td>50 (74.6)</td> <td>12 (17.9)</td> <td>5 (7.5)</td> <td>23 (34.3)</td> <td>35 (52.2)</td> <td>9 (13.4)</td> </tr> <tr> <th>7</th> <td>ER-positive</td> <td>109 (69.9)</td> <td>43 (27.6)</td> <td>4 (2.6)</td> <td>56 (35.9)</td> <td>82 (52.6)</td> <td>18 (11.5)</td> </tr> <tr> <th>8</th> <td>Endocrine therapy</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>9</th> <td>Tamoxifen</td> <td>77 (68.8)</td> <td>28 (25.0)</td> <td>7 (6.3)</td> <td>37 (33.0)</td> <td>60 (53.6)</td> <td>15 (13.4)</td> </tr> <tr> <th>10</th> <td>No tamoxifen</td> <td>85 (74.6)</td> <td>27 (23.7)</td> <td>2 (1.8)</td> <td>42 (36.8)</td> <td>59 (51.8)</td> <td>13 (11.4)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Clone</th> <th>Monkey</th> <th>Longest time to Syncytia Formation</th> <th>Longest time to Detectable p27</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Group 1</td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>109</td> <td>225</td> <td>7 days</td> <td>7 days</td> </tr> <tr> <th>2</th> <td>129</td> <td>225</td> <td>7 days</td> <td>7 days</td> </tr> <tr> <th>3</th> <td>141</td> <td>225</td> <td>7 days</td> <td>7 days</td> </tr> <tr> <th>4</th> <td>142</td> <td>225</td> <td>7 days</td> <td>7 days</td> </tr> <tr> <th>5</th> <td>169</td> <td>321</td> <td>7 days</td> <td>7 days</td> </tr> <tr> <th>6</th> <td>Group 2</td> <td></td> <td></td> <td></td> </tr> <tr> <th>7</th> <td>108</td> <td>225</td> <td>12 days</td> <td>12 days</td> </tr> <tr> <th>8</th> <td>122</td> <td>225</td> <td>12 days</td> <td>12 days</td> </tr> <tr> <th>9</th> <td>144</td> <td>225</td> <td>12 days</td> <td>12 days</td> </tr> <tr> <th>10</th> <td>146</td> <td>225</td> <td>15 days</td> <td>18 days</td> </tr> <tr> <th>11</th> <td>153</td> <td>321</td> <td>9 days</td> <td>10 days</td> </tr> <tr> <th>12</th> <td>159</td> <td>321</td> <td>12 days</td> <td>12 days</td> </tr> <tr> <th>13</th> <td>Group 3</td> <td></td> <td></td> <td></td> </tr> <tr> <th>14</th> <td>104</td> <td>225</td> <td>18 days</td> <td>14 days</td> </tr> <tr> <th>15</th> <td>115</td> <td>225</td> <td>18 days</td> <td>14 days</td> </tr> <tr> <th>16</th> <td>116</td> <td>225</td> <td>18 days</td> <td>18 days</td> </tr> <tr> <th>17</th> <td>134</td> <td>225</td> <td>18 days</td> <td>18 days</td> </tr> <tr> <th>18</th> <td>143</td> <td>225</td> <td>Never</td> <td>18 days</td> </tr> <tr> <th>19</th> <td>164</td> <td>321</td> <td>12 days</td> <td>12 days</td> </tr> <tr> <th>20</th> <td>171</td> <td>321</td> <td>Never</td> <td>15 days</td> </tr> <tr> <th>21</th> <td>173</td> <td>321</td> <td>Never</td> <td>15 days</td> </tr> <tr> <th>22</th> <td>Control</td> <td></td> <td></td> <td></td> </tr> <tr> <th>23</th> <td>SIVmac239</td> <td></td> <td>4 days</td> <td>7 days</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Env – gp41</th> <th>573</th> <th>631</th> <th>676</th> <th>713</th> <th>734</th> <th>737</th> <th>741</th> <th>751</th> <th>752</th> <th>760</th> <th>764</th> <th>767</th> <th>785</th> <th>802</th> <th>821</th> <th>850</th> <th>855</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>SIVmac239</td> <td>K</td> <td>K</td> <td>D</td> <td>M</td> <td>Q</td> <td>I</td> <td>P</td> <td>R</td> <td>D</td> <td>S</td> <td>W</td> <td>E</td> <td>S</td> <td>L</td> <td>T</td> <td>G</td> <td>T</td> </tr> <tr> <th>1</th> <td>SIVmac316</td> <td>T</td> <td>K</td> <td>D</td> <td>V</td> <td>Q</td> <td>I</td> <td>P</td> <td>G</td> <td>D</td> <td>S</td> <td>W</td> <td>Stop</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <th>2</th> <td>SIV17E-Cl</td> <td>K</td> <td>K</td> <td>N</td> <td>V</td> <td>Q</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> <td>*</td> </tr> <tr> <th>3</th> <td>SIV17E/Fr</td> <td>K</td> <td>K</td> <td>D</td> <td>M</td> <td>Q</td> <td>I</td> <td>P</td> <td>G</td> <td>D</td> <td>S</td> <td>Stop</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <th>4</th> <td>SIVmac251</td> <td>K</td> <td>N</td> <td>D</td> <td>M</td> <td>Q</td> <td>I</td> <td>P</td> <td>G</td> <td>D</td> <td>S</td> <td>W</td> <td>E</td> <td>S</td> <td>L</td> <td>T</td> <td>G</td> <td>T</td> </tr> <tr> <th>5</th> <td>SIVmac32H</td> <td>K</td> <td>D</td> <td>D</td> <td>M</td> <td>Q</td> <td>I</td> <td>P</td> <td>G</td> <td>D</td> <td>S</td> <td>W</td> <td>E</td> <td>S</td> <td>L</td> <td>T</td> <td>G</td> <td>T</td> </tr> <tr> <th>6</th> <td>SIVmac1A11</td> <td>K</td> <td>K</td> <td>D</td> <td>M</td> <td>Stop</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <th>7</th> <td>Clone 129</td> <td>K</td> <td>D</td> <td>D</td> <td>M</td> <td>Q</td> <td>T</td> <td>Q</td> <td>G</td> <td>D</td> <td>R</td> <td>W</td> <td>E</td> <td>N</td> <td>F</td> <td>A</td> <td>R</td> <td>T</td> </tr> <tr> <th>8</th> <td>Clone 169</td> <td>K</td> <td>D</td> <td>D</td> <td>M</td> <td>Q</td> <td>T</td> <td>Q</td> <td>G</td> <td>G</td> <td>R</td> <td>W</td> <td>E</td> <td>N</td> <td>F</td> <td>A</td> <td>R</td> <td>A</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>695</th> <th>737</th> <th>741</th> <th>747</th> <th>748</th> <th>751</th> <th>758</th> <th>760</th> <th>785</th> <th>794</th> <th>802</th> <th>808</th> <th>821</th> <th>831</th> <th>837</th> <th>850</th> <th>858</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>SIVmac239 (clone)</td> <td>V</td> <td>I</td> <td>P</td> <td>E</td> <td>S</td> <td>R</td> <td>G</td> <td>S</td> <td>S</td> <td>V</td> <td>L</td> <td>T</td> <td>T</td> <td>H</td> <td>V</td> <td>G</td> <td>R</td> </tr> <tr> <th>1</th> <td>SIVmac251 (stock)</td> <td>V</td> <td>I</td> <td>P</td> <td>E</td> <td>S</td> <td>G</td> <td>S</td> <td>S</td> <td>S</td> <td>A</td> <td>L</td> <td>A</td> <td>T</td> <td>Q</td> <td>G</td> <td>G</td> <td>G</td> </tr> <tr> <th>2</th> <td>SIVmac182 (stock)</td> <td>I</td> <td>I</td> <td>Q</td> <td>G/E</td> <td>G</td> <td>G</td> <td>G</td> <td>R</td> <td>S</td> <td>V</td> <td>F</td> <td>T</td> <td>T</td> <td>Q</td> <td>G</td> <td>R</td> <td>R</td> </tr> <tr> <th>3</th> <td>225 microglia</td> <td>I</td> <td>T</td> <td>Q</td> <td>G</td> <td>G</td> <td>G</td> <td>G</td> <td>R</td> <td>N</td> <td>V</td> <td>F</td> <td>T</td> <td>A</td> <td>Q</td> <td>G</td> <td>R</td> <td>R</td> </tr> <tr> <th>4</th> <td>321 microglia</td> <td>I</td> <td>T</td> <td>Q</td> <td>G</td> <td>G</td> <td>G</td> <td>G</td> <td>R</td> <td>N</td> <td>V</td> <td>F</td> <td>T</td> <td>A</td> <td>Q</td> <td>G</td> <td>R</td> <td>R</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Observed Unordered</th> <th>Genotypes/Number</th> <th>of A Alleles in Pool</th> <th>j | True Unordered Genotype</th> <th>AABB</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>α</td> <td>BBBB/ 0</td> <td>ABBB/ 1</td> <td>AABB/ 2</td> <td>AAAB/ 3</td> <td>AAAA/ 4</td> </tr> <tr> <th>1</th> <td>1</td> <td>0.063</td> <td>0.250</td> <td>0.375</td> <td>0.250</td> <td>0.063</td> </tr> <tr> <th>2</th> <td>5</td> <td>0.0002</td> <td>0.131</td> <td>0.737</td> <td>0.131</td> <td>0.0002</td> </tr> <tr> <th>3</th> <td>25</td> <td>0.000</td> <td>0.006</td> <td>0.988</td> <td>0.006</td> <td>0.000</td> </tr> <tr> <th>4</th> <td>125</td> <td>0.000</td> <td>0.000</td> <td>1.000</td> <td>0.000</td> <td>0.000</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Group (G)</th> <th>Sample</th> <th>Year</th> <th>n</th> <th>Age years mean (SD)</th> <th>Sex % males</th> <th>Education median level (range)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>1</td> <td>First population sample</td> <td>1988</td> <td>1156</td> <td>48.9 (16.0)</td> <td>50.4</td> <td>3 (1–4)*</td> </tr> <tr> <th>1</th> <td>2</td> <td>Eligible sample</td> <td>1995</td> <td>1428</td> <td>49.9 (17.2)</td> <td>49.9</td> <td>3 (1–4)**</td> </tr> <tr> <th>2</th> <td>3</td> <td>Population sample</td> <td>1995</td> <td>911</td> <td>49.2 (16.46)</td> <td>47.0</td> <td>3 (1–4)</td> </tr> <tr> <th>3</th> <td>4</td> <td>Sample group FGID</td> <td>1995</td> <td>244</td> <td>45.5 (15.3)</td> <td>36.1</td> <td>3 (2–4)</td> </tr> <tr> <th>4</th> <td>5</td> <td>Sample Group SSF</td> <td>1995</td> <td>219</td> <td>51.7 (17.6)</td> <td>51.6</td> <td>3 (1–4)</td> </tr> <tr> <th>5</th> <td>6</td> <td>Study Group FGID</td> <td>1996</td> <td>141</td> <td>45.7 (14.3)</td> <td>34.0</td> <td>3 (2–4)</td> </tr> <tr> <th>6</th> <td>7</td> <td>Study Group SSF</td> <td>1996</td> <td>97</td> <td>52.4 (15.3)</td> <td>48.0</td> <td>3 (1–4)</td> </tr> <tr> <th>7</th> <td>G2 vs G3</td> <td></td> <td></td> <td></td> <td>ns</td> <td>ns</td> <td></td> </tr> <tr> <th>8</th> <td>G2 vs G3</td> <td></td> <td></td> <td></td> <td>ns</td> <td>ns</td> <td>ns</td> </tr> <tr> <th>9</th> <td>G4 vs G6</td> <td></td> <td></td> <td></td> <td>ns</td> <td>ns</td> <td>ns</td> </tr> <tr> <th>10</th> <td>G5 vs G7</td> <td></td> <td></td> <td></td> <td>ns</td> <td>ns</td> <td>ns</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Variable</th> <th>OR (CI)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Psychological illness low</td> <td>1</td> </tr> <tr> <th>1</th> <td>High</td> <td>2.2 (1.2–4.0)</td> </tr> <tr> <th>2</th> <td>Abdominal illness low</td> <td>1</td> </tr> <tr> <th>3</th> <td>High</td> <td>2.0 (1.1–3.8)</td> </tr> <tr> <th>4</th> <td>Age (continuous)</td> <td>1.0 (0.99–1.0)</td> </tr> <tr> <th>5</th> <td>Sex female</td> <td>1</td> </tr> <tr> <th>6</th> <td>Male</td> <td>0.7 (0.40–1.3)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>N = 43</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Retrospective</td> <td>7</td> </tr> <tr> <th>1</th> <td>Planning</td> <td>4</td> </tr> <tr> <th>2</th> <td>Not in 3rd trimester</td> <td>32</td> </tr> <tr> <th>3</th> <td>Discontinued drug (3 abruptly)</td> <td>5</td> </tr> <tr> <th>4</th> <td>Considered discontinuing drug but did not</td> <td>6</td> </tr> <tr> <th>5</th> <td>Recommendations to discontinue (MD)</td> <td>5</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Bronchus</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Superficial Epithelium</td> <td>AQP5 (Apical), AQP4 (Basolateral)</td> </tr> <tr> <th>1</th> <td>Basal Cells</td> <td>AQP3</td> </tr> <tr> <th>2</th> <td>Submucosal Glands</td> <td>AQP5 (Apical), AQP3,4 (Basolateral)</td> </tr> <tr> <th>3</th> <td>Bronchioles</td> <td></td> </tr> <tr> <th>4</th> <td>Pseudostratified</td> <td>AQP3 (Apical), AQP4 (Basolateral)</td> </tr> <tr> <th>5</th> <td>Alveolar Cells</td> <td></td> </tr> <tr> <th>6</th> <td>Type I</td> <td>AQP5 (Apical), AQP4 (Human only--?)</td> </tr> <tr> <th>7</th> <td>Type II</td> <td>AQP5 (Mouse only, apical)</td> </tr> <tr> <th>8</th> <td></td> <td>AQP3 (Human only, basolateral)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>B</th> <th>S.E.</th> <th>Wald</th> <th>df</th> <th>Sig.</th> <th>Odds ratio Exp(B) (90% C.I.)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>INITIAL MODEL*</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Diagnosis</td> <td>-2.471</td> <td>0.617</td> <td>16.036</td> <td>1</td> <td>0.000</td> <td>0.085 (0.031–0.233)</td> </tr> <tr> <th>2</th> <td>Expectation</td> <td>-0.012</td> <td>0.407</td> <td>0.001</td> <td>1</td> <td>0.977</td> <td>0.988 (0.506–1.929)</td> </tr> <tr> <th>3</th> <td>Health insurance</td> <td>1.015</td> <td>0.453</td> <td>5.030</td> <td>1</td> <td>0.025</td> <td>2.760 (1.311–5.810)</td> </tr> <tr> <th>4</th> <td>Gender</td> <td>-0.571</td> <td>0.388</td> <td>2.165</td> <td>1</td> <td>0.141</td> <td>0.565 (0.298–1.070)</td> </tr> <tr> <th>5</th> <td>Age</td> <td>-0.006</td> <td>0.009</td> <td>0.410</td> <td>1</td> <td>0.522</td> <td>0.994 (0.980–1.009)</td> </tr> <tr> <th>6</th> <td>Patient satisfaction</td> <td>-0.353</td> <td>0.374</td> <td>0.887</td> <td>1</td> <td>0.346</td> <td>0.703 (0.380–1.301)</td> </tr> <tr> <th>7</th> <td>Performance score</td> <td>-0.286</td> <td>0.176</td> <td>2.637</td> <td>1</td> <td>0.104</td> <td>0.752 (0.563–1.004)</td> </tr> <tr> <th>8</th> <td>Severity</td> <td>0.614</td> <td>0.465</td> <td>1.743</td> <td>1</td> <td>0.187</td> <td>1.848 (0.860–3.970)</td> </tr> <tr> <th>9</th> <td>Urgency</td> <td>-0.189</td> <td>0.506</td> <td>0.140</td> <td>1</td> <td>0.708</td> <td>0.827 (0.360–1.902)</td> </tr> <tr> <th>10</th> <td>Worried</td> <td>-0.170</td> <td>0.531</td> <td>0.103</td> <td>1</td> <td>0.748</td> <td>0.844 (0.352–2.019)</td> </tr> <tr> <th>11</th> <td>Education Low</td> <td></td> <td></td> <td>1.724</td> <td>2</td> <td>0.422</td> <td></td> </tr> <tr> <th>12</th> <td>Middle</td> <td>-0.567</td> <td>0.451</td> <td>1.585</td> <td>1</td> <td>0.208</td> <td>0.567 (0.270–1.190)</td> </tr> <tr> <th>13</th> <td>High</td> <td>0.036</td> <td>0.473</td> <td>0.006</td> <td>1</td> <td>0.939</td> <td>1.037 (0.476–2.258)</td> </tr> <tr> <th>14</th> <td>Constant</td> <td>4.101</td> <td>2.355</td> <td>3.031</td> <td>1</td> <td>0.082</td> <td>60.372</td> </tr> <tr> <th>15</th> <td>FINAL MODEL#</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>16</th> <td>Diagnosis a</td> <td>-2.749</td> <td>0.478</td> <td>33.081</td> <td>1</td> <td>0.000</td> <td>0.064 (0.029–0.140)</td> </tr> <tr> <th>17</th> <td>Health Insurance b</td> <td>0.860</td> <td>0.388</td> <td>4.905</td> <td>1</td> <td>0.027</td> <td>2.363 (1.248–4.476)</td> </tr> <tr> <th>18</th> <td>Severity c</td> <td>0.578</td> <td>0.349</td> <td>2.734</td> <td>1</td> <td>0.098</td> <td>1.782 (1.003–3.166)</td> </tr> <tr> <th>19</th> <td>Constant</td> <td>0.863</td> <td>0.573</td> <td>2.266</td> <td>1</td> <td>0.132</td> <td>2.369</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>CONSULTATION AT GP COOPERATIVE</th> <th>B</th> <th>S.E.</th> <th>Wald</th> <th>df</th> <th>Sig.</th> <th>Odds ratio Exp(B) (90% C.I.)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>INITIAL MODEL*</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Diagnosis</td> <td>-1.934</td> <td>0.662</td> <td>8.525</td> <td>1</td> <td>0.004</td> <td>0.145 (0.049–0.430)</td> </tr> <tr> <th>2</th> <td>Expectation</td> <td>0.502</td> <td>0.660</td> <td>0.577</td> <td>1</td> <td>0.447</td> <td>1.652 (0.557–4.894)</td> </tr> <tr> <th>3</th> <td>Health insurance</td> <td>-0.038</td> <td>0.555</td> <td>0.005</td> <td>1</td> <td>0.945</td> <td>0.962 (0.386–2.397)</td> </tr> <tr> <th>4</th> <td>Gender</td> <td>-0.079</td> <td>0.418</td> <td>0.036</td> <td>1</td> <td>0.850</td> <td>0.924 (0.464–1.839)</td> </tr> <tr> <th>5</th> <td>Age</td> <td>0.003</td> <td>0.010</td> <td>0.106</td> <td>1</td> <td>0.745</td> <td>1.003 (0.987–1.020)</td> </tr> <tr> <th>6</th> <td>Patient satisfaction</td> <td>0.211</td> <td>0.486</td> <td>0.188</td> <td>1</td> <td>0.664</td> <td>1.235 (0.555–2.745)</td> </tr> <tr> <th>7</th> <td>Performance score</td> <td>0.035</td> <td>0.239</td> <td>0.021</td> <td>1</td> <td>0.884</td> <td>1.035 (0.699–1.534)</td> </tr> <tr> <th>8</th> <td>Severity</td> <td>0.549</td> <td>0.549</td> <td>0.999</td> <td>1</td> <td>0.318</td> <td>1.732 (0.701–4.274)</td> </tr> <tr> <th>9</th> <td>Urgency</td> <td>-0.531</td> <td>0.513</td> <td>1.072</td> <td>1</td> <td>0.300</td> <td>0.588 (0.253–1.367)</td> </tr> <tr> <th>10</th> <td>Worried</td> <td>1.014</td> <td>0.689</td> <td>2.165</td> <td>1</td> <td>0.141</td> <td>2.757 (0.887–8.566)</td> </tr> <tr> <th>11</th> <td>Education Low</td> <td></td> <td></td> <td>0.341</td> <td>2</td> <td>0.843</td> <td></td> </tr> <tr> <th>12</th> <td>Middle</td> <td>0.244</td> <td>0.510</td> <td>0.229</td> <td>1</td> <td>0.632</td> <td>1.277 (0.551–2.957)</td> </tr> <tr> <th>13</th> <td>High</td> <td>-0.130</td> <td>0.565</td> <td>0.053</td> <td>1</td> <td>0.818</td> <td>0.878 (0.347–2.223)</td> </tr> <tr> <th>14</th> <td>Constant</td> <td>-1.564</td> <td>3.021</td> <td>0.268</td> <td>1</td> <td>0.605</td> <td>0.209</td> </tr> <tr> <th>15</th> <td>FINAL MODEL#</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>16</th> <td>Diagnosis a</td> <td>-2.075</td> <td>0.484</td> <td>18.359</td> <td>1</td> <td>0.000</td> <td>0.126 (0.057–0.279)</td> </tr> <tr> <th>17</th> <td>Worried b</td> <td>1.073</td> <td>0.520</td> <td>4.266</td> <td>1</td> <td>0.039</td> <td>2.925 (1.244–6.876)</td> </tr> <tr> <th>18</th> <td>Constant</td> <td>-0.083</td> <td>0.651</td> <td>0.016</td> <td>1</td> <td>0.899</td> <td>0.920</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Ka, M-1</th> <th>-∆H, kcal/mole</th> <th>-∆G, kcal/mole</th> <th>-∆S, cal/moleK</th> <th>Nr exp.</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>27°C</td> <td>192 ± 5</td> <td>6.27 ± 0.10</td> <td>3.122</td> <td>10.5</td> <td>2</td> </tr> <tr> <th>1</th> <td>27°C, 10% PEG</td> <td>280 ± 4</td> <td>5.82 ± 0.05</td> <td>3.347</td> <td>8.2</td> <td>4</td> </tr> <tr> <th>2</th> <td>10°C</td> <td>362 ± 3</td> <td>6.25 ± 0.03</td> <td>3.301</td> <td>10.4</td> <td>2</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Treatment</th> <th></th> <th></th> <th>Response</th> <th>(%)</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>N</td> <td>Complete</td> <td>Partial</td> <td>Death or peritoneal metastasis</td> <td>None</td> </tr> <tr> <th>1</th> <td>Ad.p35 + Ad.p40 + Ad.CD/5-FC</td> <td>15</td> <td>4 (27)</td> <td>4 (27)</td> <td>0 (0)</td> <td>7 (46)</td> </tr> <tr> <th>2</th> <td>Ad.p35 + Ad.p40</td> <td>15</td> <td>1 (7)</td> <td>2 (14)</td> <td>‡2 (13)</td> <td>10 (66)</td> </tr> <tr> <th>3</th> <td>Ad.CD/5-FC</td> <td>15</td> <td>1 (7)</td> <td>0 (0)</td> <td>†1 (7)</td> <td>13 (86)</td> </tr> <tr> <th>4</th> <td>Ad.GFP</td> <td>15</td> <td>0 (0)</td> <td>0 (0)</td> <td>†1 (7)</td> <td>14 (93)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>DA sample (N = 60)</th> <th>Historical controls (No./Total)</th> <th>Fisher's Exact Test P-value</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Knowledge of personal pathology results</td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Knew PSA</td> <td>56 (93%)</td> <td>160/181 (88%)</td> <td>0.34</td> </tr> <tr> <th>2</th> <td>Informed of stage of cancer</td> <td>53 (88%)</td> <td>178/181 (98%)</td> <td>0.00</td> </tr> <tr> <th>3</th> <td>Knew grade of cancer</td> <td>57 (95%)</td> <td>178/184 (97%)</td> <td>0.69</td> </tr> <tr> <th>4</th> <td>Knowledge of treatment options</td> <td></td> <td></td> <td></td> </tr> <tr> <th>5</th> <td>Knew all of age, grade, stage, health, and PSA are at least somewhat important for treatment decision.</td> <td>52 (87%)</td> <td>142/184 (77%)</td> <td>0.14</td> </tr> <tr> <th>6</th> <td>Believed watchful waiting to be a standard treatment</td> <td>52 (87%)</td> <td>138/184 (75%)</td> <td>0.07</td> </tr> <tr> <th>7</th> <td>Believed external radiation to be a standard treatment</td> <td>53 (88%)</td> <td>173/184 (94%)</td> <td>0.16</td> </tr> <tr> <th>8</th> <td>Believed brachytherapy to be a standard treatment</td> <td>47 (78%)</td> <td>143/184 (78%)</td> <td>&gt;0.99</td> </tr> <tr> <th>9</th> <td>Believed surgery to be a standard treatment</td> <td>57 (95%)</td> <td>177/184 (96%)</td> <td>0.71</td> </tr> <tr> <th>10</th> <td>Discussed watchful waiting with physician</td> <td>28 (47%)</td> <td>72/184 (39%)</td> <td>0.36</td> </tr> <tr> <th>11</th> <td>Discussed external radiation with physician</td> <td>53 (88%)</td> <td>166/184 (90%)</td> <td>0.63</td> </tr> <tr> <th>12</th> <td>Discussed brachytherapy with physician</td> <td>38 (63%)</td> <td>121/184 (66%)</td> <td>0.76</td> </tr> <tr> <th>13</th> <td>Discussed surgery with physician</td> <td>59 (98%)</td> <td>163/184 (89%)</td> <td>0.02</td> </tr> <tr> <th>14</th> <td>Knowledge of side effects</td> <td></td> <td></td> <td></td> </tr> <tr> <th>15</th> <td>Knew surgery associated with incontinence</td> <td>59 (98%)</td> <td>172/184 (93%)</td> <td>0.20</td> </tr> <tr> <th>16</th> <td>Knew surgery associated with impotence</td> <td>58 (97%)</td> <td>172/184 (93%)</td> <td>0.53</td> </tr> <tr> <th>17</th> <td>Knew surgery associated with painful bowel movements</td> <td>33 (55%)</td> <td>82/184 (45%)</td> <td>0.18</td> </tr> <tr> <th>18</th> <td>Knew radiation associated with incontinence</td> <td>48 (80%)</td> <td>113/184 (61%)</td> <td>0.01</td> </tr> <tr> <th>19</th> <td>Knew radiation associated with impotence</td> <td>56 (93%)</td> <td>145/183 (79%)</td> <td>0.01</td> </tr> <tr> <th>20</th> <td>Knew radiation associated with painful bowel movements</td> <td>46 (77%)</td> <td>118/184 (64%)</td> <td>0.08</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th colspan="7" halign="left"></th> </tr> <tr> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Amount of information</td> <td>Much less than needed 5%</td> <td>A little less than needed 14%</td> <td>About right 77%</td> <td>A little more than needed 4%</td> <td></td> <td>DK or refused 7%</td> </tr> <tr> <th>1</th> <td>Length</td> <td>Much too short 0%</td> <td>A little too short 11%</td> <td>About right 84%</td> <td>A little too long 5%</td> <td></td> <td>DK or refused 5%</td> </tr> <tr> <th>2</th> <td>Clarity of words</td> <td>All clear 44%</td> <td>Mostly clear 51%</td> <td>Some clear/ not 5%</td> <td>Most unclear 0%</td> <td>All unclear 0%</td> <td>DK or refused 2%</td> </tr> <tr> <th>3</th> <td>Difficulty of numbers</td> <td>Very easy 64%</td> <td>Somewhat Easy 24%</td> <td>Somewhat difficult 12%</td> <td>Very difficult 0%</td> <td></td> <td>DK or refused 3%</td> </tr> <tr> <th>4</th> <td>Treatment description balance</td> <td>Complete balance 80%</td> <td>Slanted to surgery 9%</td> <td>Slanted to radiation 4%</td> <td>Slanted to WW 7%</td> <td></td> <td>DK or refused 8%</td> </tr> <tr> <th>5</th> <td>Recommend DA to a friend?</td> <td>Definitely would 78%</td> <td>Probably would 20%</td> <td>Unsure 0%</td> <td>Probably would not 0%</td> <td>Definitely Would not 2%</td> <td>DK or refused 2%</td> </tr> <tr> <th>6</th> <td>DA improved understanding</td> <td>Definitely did 49%</td> <td>Probably did 42%</td> <td>Unsure 2%</td> <td>Probably did not 2%</td> <td>Definitely did not 5%</td> <td>DK or refused 2%</td> </tr> <tr> <th>7</th> <td>Numbers influenced my decision</td> <td>Definitely did 12%</td> <td>Probably did 41%</td> <td>Unsure 2%</td> <td>Probably did not 22%</td> <td>Definitely did not 22%</td> <td>DK or refused 3%</td> </tr> <tr> <th>8</th> <td>DA helped decision making</td> <td>A lot 14%</td> <td>Quite a bit 30%</td> <td>Moderate 32%</td> <td>A little 16%</td> <td>Not at all 9%</td> <td>DK or refused 5%</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Surgical complications</th> <th>General complications</th> <th>Perioperative Mortality</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Surgical procedure (p = 0.0004)</td> <td>Surgical procedure (p = 0.0001)</td> <td>Surgical procedure (p = 0.0068)</td> </tr> <tr> <th>1</th> <td>Tumor location (p = 0.0204)</td> <td>Packed erythrocyte transfusion (p = 0.0009)</td> <td>Pulmonary PD (p = 0.0096)</td> </tr> <tr> <th>2</th> <td>Packed erythrocyte transfusion (p = 0.0493)</td> <td>Patient age (p = 0.0039)</td> <td>Packed erythrocyte transfusion (p = 0.0099)</td> </tr> <tr> <th>3</th> <td></td> <td>Nutritional status (p = 0.0284)</td> <td></td> </tr> <tr> <th>4</th> <td></td> <td>ASA-classification (p = 0.0486)</td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>parameter</th> <th>Squamous cell carcinoma (n = 229)</th> <th>Adenocarcinoma (n = 150)</th> <th>p-value</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>- Surgical procedure (% transhiatal)</td> <td>30.6</td> <td>68.7</td> <td>0.0001*</td> </tr> <tr> <th>1</th> <td>- Esophageal substitute (% gastric tube)</td> <td>90.8</td> <td>97.3</td> <td>0.027*</td> </tr> <tr> <th>2</th> <td>- Repositioning (% esophageal bed)</td> <td>83.7</td> <td>95.3</td> <td>0.001*</td> </tr> <tr> <th>3</th> <td>- Number of removed abdominal LN (n)</td> <td>11 (0–55)</td> <td>13 (0–51)</td> <td>0.0146*</td> </tr> <tr> <th>4</th> <td>- Number of removed thoracic LN (n)</td> <td>11 (0–47)</td> <td>6 (0–83)</td> <td>0.0011*</td> </tr> <tr> <th>5</th> <td>- Operative time (min)</td> <td>305 (115–560)</td> <td>270 (160–540)</td> <td>0.0001*</td> </tr> <tr> <th>6</th> <td>- Intraoperative blood loss (ml)</td> <td>1000 (200–5000)</td> <td>800 (0–7500)</td> <td>0.2224</td> </tr> <tr> <th>7</th> <td>- Units of transfused packed erythrocytes (n)</td> <td>1.5 (0–38)</td> <td>0 (0–14)</td> <td>0.0495*</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th></th> <th>Putative S/MARs</th> <th>in 5' regions (%)*</th> <th>Putative S/MARs</th> <th>in 3' regions (%)*</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Prediction scheme</td> <td>Hkg#</td> <td>Tsg§</td> <td>Hkg#</td> <td>Tsg§</td> </tr> <tr> <th>1</th> <td>presence of S/MAR</td> <td>26.1</td> <td>34.1</td> <td>19.1</td> <td>20.6</td> </tr> <tr> <th>2</th> <td>absence of S/MAR</td> <td>26.1</td> <td>19.2</td> <td>34.5</td> <td>25.1</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Length (bp)*</th> <th></th> <th>P-value in intervals</th> <th>of scores</th> <th></th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>-1.2 to -1</td> <td>-1 to -0.8</td> <td>0.8 to 1</td> <td>1 to 1.2</td> </tr> <tr> <th>1</th> <td>400</td> <td>3.53E-13</td> <td>8.73E-17</td> <td>1.28E-17</td> <td>4.45E-23</td> </tr> <tr> <th>2</th> <td>800</td> <td>1.16E-24</td> <td>6.27E-24</td> <td>6.64E-12</td> <td>6.65E-22</td> </tr> <tr> <th>3</th> <td>1200</td> <td>6.91E-26</td> <td>1.44E-24</td> <td>2.10E-09</td> <td>1.64E-18</td> </tr> <tr> <th>4</th> <td>1600</td> <td>1.72E-24</td> <td>6.99E-24</td> <td>2.72E-07</td> <td>5.63E-15</td> </tr> <tr> <th>5</th> <td>2000</td> <td>2.55E-25</td> <td>1.84E-25</td> <td>3.22E-05</td> <td>6.71E-13</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Repeat category</th> <th>No. of copies</th> <th></th> <th>% of the total sequences</th> <th>covered by the repeat</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td>Hkg#</td> <td>Tsg*</td> <td>Hkg#</td> <td>Tsg*</td> </tr> <tr> <th>1</th> <td>Alu</td> <td>866</td> <td>575</td> <td>20.1</td> <td>12.3</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Unified Nomenclature</th> <th>Domain</th> <th>Human</th> <th>S. cerevisiae (Core subunits)</th> <th>S. pombe Csn7Bp complex</th> <th>S. pombe Int6p complex</th> <th>S. pombe eIF3b complex</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>eIF3a</td> <td>PCI</td> <td>p170</td> <td>Tif32p</td> <td>p107</td> <td>p107</td> <td>p107</td> </tr> <tr> <th>1</th> <td>eIF3b</td> <td>RRM</td> <td>p116</td> <td>Prt1p</td> <td>p84</td> <td>p84</td> <td>p84</td> </tr> <tr> <th>2</th> <td>eIF3c</td> <td>PCI</td> <td>p110</td> <td>Nip1p</td> <td>p104</td> <td>p104</td> <td>p104</td> </tr> <tr> <th>3</th> <td>eIF3d</td> <td>-</td> <td>p66</td> <td>-</td> <td>-</td> <td>Moe1p</td> <td>Moe1p</td> </tr> <tr> <th>4</th> <td>eIF3e</td> <td>PCI</td> <td>p48</td> <td>-</td> <td>-</td> <td>Int6p</td> <td>Int6p</td> </tr> <tr> <th>5</th> <td>eIF3f</td> <td>MPN</td> <td>p47</td> <td>-</td> <td>Csn6p</td> <td>Csn6p</td> <td>Csn6p</td> </tr> <tr> <th>6</th> <td>eIF3g</td> <td>RRM/Zn finger</td> <td>p44</td> <td>Tif35p</td> <td>Tif35p</td> <td>Tif35p</td> <td>Tif35p</td> </tr> <tr> <th>7</th> <td>eIF3h</td> <td>MPN</td> <td>p40</td> <td>-</td> <td>p40</td> <td>-</td> <td>p40</td> </tr> <tr> <th>8</th> <td>eIF3i</td> <td>WD repeat</td> <td>p36</td> <td>Tif34p</td> <td>Sum1p</td> <td>Sum1p</td> <td>Sum1p</td> </tr> <tr> <th>9</th> <td>eIF3j</td> <td>-</td> <td>p35</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <th>10</th> <td>eIF3k</td> <td>PCI</td> <td>p28</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <th>11</th> <td>eIF3l</td> <td>PCI</td> <td>p67</td> <td>-</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <th>12</th> <td>eIF3m</td> <td>PCI</td> <td>GA17 (?)</td> <td>-</td> <td>Csn7Bp</td> <td>-</td> <td>Csn7Bp</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Name</th> <th>Genotype</th> <th></th> <th>Source</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>DS448/1</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>h+</td> <td>Lab stock</td> </tr> <tr> <th>1</th> <td>DS448/2</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>h-</td> <td>Lab stock</td> </tr> <tr> <th>2</th> <td>C399/3</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>csn5.13myc kan h-</td> <td>Lab stock</td> </tr> <tr> <th>3</th> <td>C485/3</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3m.13myc kan h-</td> <td>Lab stock</td> </tr> <tr> <th>4</th> <td>C617/1</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3m.CBP.tev.5proA kan h-</td> <td>Lab stock</td> </tr> <tr> <th>5</th> <td>C642/1</td> <td>leu1-32 ura4-d18</td> <td>diploid, eif3f/eif3f::ura4</td> <td>This study</td> </tr> <tr> <th>6</th> <td>C642/2</td> <td>leu1-32 ura4-d18</td> <td>diploid, eif3f/eif3f::ura4</td> <td>This study</td> </tr> <tr> <th>7</th> <td>C648</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3e.cbp.tev.5proA kan h+</td> <td>This study</td> </tr> <tr> <th>8</th> <td>C650/1</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3f::ura4 pRep81.6xhis.myc.eif3f h-</td> <td>This study</td> </tr> <tr> <th>9</th> <td>C650/2</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3m::ura4 pRep81.6xhis.myc.eif3m h-</td> <td>This study</td> </tr> <tr> <th>10</th> <td>C652/1</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3e::ura4 h+</td> <td>This study</td> </tr> <tr> <th>11</th> <td>C663/1</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3m.gfp kan h-</td> <td>This study</td> </tr> <tr> <th>12</th> <td>C663/2</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3e.gfp kan h-</td> <td>This study</td> </tr> <tr> <th>13</th> <td>C665</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3e.13myc kan h-</td> <td>This study</td> </tr> <tr> <th>14</th> <td>C701</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3b.gfp kan, h-</td> <td>This study</td> </tr> <tr> <th>15</th> <td>C702</td> <td>leu1-32 ura4-d18 ade6-704</td> <td>eif3b.cbp.tev.5proA kan h-</td> <td>This study</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Gene Name</th> <th>Sequence</th> <th>Product Size (bp)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>actinF</td> <td>GAGCTTCCTGATGGTCAAGT</td> <td>200</td> </tr> <tr> <th>1</th> <td>actinR</td> <td>GGATACATAGTGGTACCACC</td> <td></td> </tr> <tr> <th>2</th> <td>cdc16F</td> <td>AAGTTAGCGCCCAAATCACC</td> <td>150</td> </tr> <tr> <th>3</th> <td>cdc16R</td> <td>TTTTGAATGCCCCCCCACGG</td> <td></td> </tr> <tr> <th>4</th> <td>gar2F</td> <td>GGTGCCATTGAGAAACCTTC</td> <td>150</td> </tr> <tr> <th>5</th> <td>gar2R</td> <td>CCGAACCTTCAAAGAAATCA</td> <td></td> </tr> <tr> <th>6</th> <td>pof6F</td> <td>TCTGATCGGCCTAAGCTGTC</td> <td>150</td> </tr> <tr> <th>7</th> <td>pof6R</td> <td>CAATCTTGCAAATTCAACTC</td> <td></td> </tr> <tr> <th>8</th> <td>rpn5F</td> <td>TGAGAAGCAAGTTCGTCAGG</td> <td>160</td> </tr> <tr> <th>9</th> <td>rpn5R</td> <td>TGAAACAATCGATGACAAGT</td> <td></td> </tr> <tr> <th>10</th> <td>rps8-1F</td> <td>AAGCGTATTCACGAGGTCCG</td> <td>150</td> </tr> <tr> <th>11</th> <td>rps8-1R</td> <td>CAACTCGTTGTTAGAAGGGT</td> <td></td> </tr> <tr> <th>12</th> <td>scd1F</td> <td>TCAGAGTTGGCTGCTTTCTT</td> <td>150</td> </tr> <tr> <th>13</th> <td>scd1R</td> <td>ATCCATTGTGTGCCCTGTTC</td> <td></td> </tr> <tr> <th>14</th> <td>SPAC1348.05F</td> <td>CTTAGTGAACAGTTTGGAAG</td> <td>150</td> </tr> <tr> <th>15</th> <td>SPAC1348.05R</td> <td>TGATAAACCAACGGATCCGA</td> <td></td> </tr> <tr> <th>16</th> <td>SPAC21E11.04F</td> <td>GAGACATCACCTGCTCCAGA</td> <td>150</td> </tr> <tr> <th>17</th> <td>SPAC21E11.04R</td> <td>TTTGCTCCGGTGACTAGGTG</td> <td></td> </tr> <tr> <th>18</th> <td>SPBC12C2.06F</td> <td>TCTGTTCCCAAACCTCAAGC</td> <td>150</td> </tr> <tr> <th>19</th> <td>SPBC12C2.06R</td> <td>ATCGATTTTTGCACCTTTAG</td> <td></td> </tr> <tr> <th>20</th> <td>SPBC1683.01F</td> <td>GGCCGTAAATTTGTCTACGG</td> <td>150</td> </tr> <tr> <th>21</th> <td>SPBC1683.01R</td> <td>ACCACCAATACCAACACCAA</td> <td></td> </tr> <tr> <th>22</th> <td>SPBC36B7.03F</td> <td>CTCTCAATTAAATTTCACCC</td> <td>150</td> </tr> <tr> <th>23</th> <td>SPBC36B7.03R</td> <td>AGGAGTACCGTATAAAGCAT</td> <td></td> </tr> <tr> <th>24</th> <td>SPCC70.05cF</td> <td>GTACCTGGAAATAACTCTCC</td> <td>150</td> </tr> <tr> <th>25</th> <td>SPCC70.05cR</td> <td>CATAGCCTTTTCTAAGAGAT</td> <td></td> </tr> <tr> <th>26</th> <td>tf2-12F</td> <td>AAGCATGTACCAGAGATAGG</td> <td>150</td> </tr> <tr> <th>27</th> <td>tf2-12R</td> <td>TGAATCACCTAGAAGAATTA</td> <td></td> </tr> <tr> <th>28</th> <td>ung1F</td> <td>ACTTTGGAGAGTTCTTGGTT</td> <td>150</td> </tr> <tr> <th>29</th> <td>ung1R</td> <td>TGGAGTATGATGTGACCATG</td> <td></td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Class of mutants</th> <th>Gene or ORF name deleted</th> <th>Functional group</th> <th>Response HAP in spot tests†</th> <th>Induced mutant frequency (×10-7) by HAP#</th> <th>Survival in presence of HAP#</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Wild type</td> <td></td> <td></td> <td>-</td> <td>400</td> <td>100%</td> </tr> <tr> <th>1</th> <td>Class I: mutants hypersensitive to HAP</td> <td>HAM1</td> <td>DNA1</td> <td>HM, HS</td> <td>13000</td> <td>17%</td> </tr> <tr> <th>2</th> <td></td> <td>ADE12*</td> <td>DNA</td> <td>HM, HS</td> <td>10000</td> <td>30%</td> </tr> <tr> <th>3</th> <td></td> <td>AAH1*</td> <td>DNA</td> <td>M, S</td> <td>5500</td> <td>30%</td> </tr> <tr> <th>4</th> <td></td> <td>ADE2</td> <td>DNA</td> <td>M, S</td> <td>4400</td> <td>70%</td> </tr> <tr> <th>5</th> <td>II class: Mutants sensitive to mutagenic effect of HAP</td> <td>VIP1</td> <td>Cell2</td> <td>M, S</td> <td>840</td> <td>76%</td> </tr> <tr> <th>6</th> <td></td> <td>VID27</td> <td>Metabolic3</td> <td>M, S</td> <td>600°</td> <td>82%</td> </tr> <tr> <th>7</th> <td></td> <td>IPK1</td> <td>Metabolic</td> <td>M, S</td> <td>1400</td> <td>100%</td> </tr> <tr> <th>8</th> <td></td> <td>ADE5,7</td> <td>DNA</td> <td>M</td> <td>1900</td> <td>100%</td> </tr> <tr> <th>9</th> <td></td> <td>ADE8</td> <td>DNA</td> <td>M</td> <td>1500</td> <td>100%</td> </tr> <tr> <th>10</th> <td></td> <td>ADE6</td> <td>DNA</td> <td>M</td> <td>1100</td> <td>100%</td> </tr> <tr> <th>11</th> <td></td> <td>RIM101</td> <td>meiosis</td> <td>M</td> <td>1100</td> <td>100%</td> </tr> <tr> <th>12</th> <td></td> <td>ADE3</td> <td>DNA</td> <td>M</td> <td>940</td> <td>100%</td> </tr> <tr> <th>13</th> <td></td> <td>ADE1</td> <td>DNA</td> <td>M</td> <td>860</td> <td>100%</td> </tr> <tr> <th>14</th> <td></td> <td>YGR035c</td> <td>unknown</td> <td>M</td> <td>500°</td> <td>100%</td> </tr> <tr> <th>15</th> <td></td> <td>Yjl055w*</td> <td>Metabolic</td> <td>M</td> <td>500°</td> <td>100%</td> </tr> <tr> <th>16</th> <td>Class III: Mutants sensitive to killing</td> <td>YMl013c-a</td> <td>Unknown</td> <td>S</td> <td>230°</td> <td>60%</td> </tr> <tr> <th>17</th> <td></td> <td>SHE4</td> <td>Cell</td> <td>S</td> <td>600°</td> <td>30%</td> </tr> <tr> <th>18</th> <td></td> <td>TRP2</td> <td>Metabolic</td> <td>HS</td> <td>250°</td> <td>60%</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Finding</th> <th>BASDAI</th> <th>BASMI</th> <th>BASFI</th> <th>PatGA</th> <th>PhysGA</th> <th>NRS-P</th> <th>ESR (mm/h)</th> <th>CRP (mg/l)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>At time point 1a</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>1</th> <td>Mean ± SD</td> <td>2.5 ± 1.8**</td> <td>2.7 ± 2.0*</td> <td>2.9 ± 2.4**</td> <td>2.6 ± 1.5**</td> <td>2.6 ± 2.1**</td> <td>2.6 ± 2.1**</td> <td>10.5 ± 7.3**</td> <td>3.1 ± 4.2**</td> </tr> <tr> <th>2</th> <td>Median</td> <td>2.4</td> <td>2.0</td> <td>2.5</td> <td>4.0</td> <td>2.0</td> <td>2.0</td> <td>8.0</td> <td>1.1</td> </tr> <tr> <th>3</th> <td>Range</td> <td>0.0 - 6.8</td> <td>0.0 - 7.0</td> <td>0.0 - 8.3</td> <td>0.0 - 8.0</td> <td>0.0 - 4.0</td> <td>0.0 - 7.0</td> <td>2.0 - 32.0</td> <td>0.0 - 19.0</td> </tr> <tr> <th>4</th> <td>At time point 2a</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>5</th> <td>Mean ± SD</td> <td>6.1 ± 1.4**</td> <td>3.2 ± 2.2*</td> <td>5.8 ± 1.8**</td> <td>6.9 ± 2.1**</td> <td>7.0 ± 1.5**</td> <td>7.1 ± 1.7**</td> <td>31.5 ± 29.7**</td> <td>20.7 ± 23.7**</td> </tr> <tr> <th>6</th> <td>Median</td> <td>6.2</td> <td>3.0</td> <td>5.7</td> <td>7.0</td> <td>7.0</td> <td>7.0</td> <td>23.0</td> <td>14.0</td> </tr> <tr> <th>7</th> <td>Range</td> <td>4.0 - 9.2</td> <td>0.0 - 9.0</td> <td>1.2 - 9.1</td> <td>4.0 - 10.0</td> <td>4.0 - 10.0</td> <td>0.0 - 10.0</td> <td>4.0 - 150.0</td> <td>0.3 - 126.0</td> </tr> <tr> <th>8</th> <td>Change between</td> <td>time points 1 and</td> <td>2</td> <td></td> <td></td> <td></td> <td></td> <td></td> <td></td> </tr> <tr> <th>9</th> <td>Mean ± SD</td> <td>3.6 ± 1.7</td> <td>0.5 ± 1.5</td> <td>2.9 ± 2.0</td> <td>4.3 ± 1.9</td> <td>4.4 ± 1.8</td> <td>4.5 ± 2.2</td> <td>21.0 ± 29.7</td> <td>17.6 ± 23.4</td> </tr> <tr> <th>10</th> <td>Median</td> <td>3.6</td> <td>0.5</td> <td>2.5</td> <td>4.0</td> <td>4.0</td> <td>4.0</td> <td>12.0</td> <td>11.5</td> </tr> <tr> <th>11</th> <td>Range</td> <td>-1.2 - 6.7</td> <td>-4.0 - 3.0</td> <td>-0.5 - 7.8</td> <td>-2.0 - 8.0</td> <td>-2.0 - 8.0</td> <td>-1.0 - 8.0</td> <td>-6.0 - 146.0</td> <td>-6.3 - 123.0</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Parameter</th> <th>RA patients (n = 8)</th> <th>AC patients (n = 3)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>Age (years)</td> <td>58 (34–69)</td> <td>56 (49–68)</td> </tr> <tr> <th>1</th> <td>Sex (no. of males/females)</td> <td>4/4</td> <td>3/0</td> </tr> <tr> <th>2</th> <td>Disease duration (months)</td> <td>60 (4–360)</td> <td>2 (1–12)</td> </tr> <tr> <th>3</th> <td>Rheumatoid factor</td> <td>7 positive; 1 negative</td> <td>1 positive; 2 negative</td> </tr> <tr> <th>4</th> <td>Tender joint count</td> <td>9 (5–15)</td> <td>1 (1–2)</td> </tr> <tr> <th>5</th> <td>Swollen joint count</td> <td>11 (5–19)</td> <td>2 (1–23)</td> </tr> <tr> <th>6</th> <td>ESR (mm/h)</td> <td>46 (25–69)</td> <td>38 (28–43)</td> </tr> <tr> <th>7</th> <td>Erosive disease</td> <td>6 positive; 2 negative</td> <td>None</td> </tr> <tr> <th>8</th> <td>No. of DMARDs</td> <td>4.5 (1–5)</td> <td>0</td> </tr> <tr> <th>9</th> <td>Leukocytes in SF (109/l)</td> <td>6.3 (4.5–7.0)</td> <td>4.3 (4.2–4.5)</td> </tr> <tr> <th>10</th> <td>CRP (mg/l)</td> <td>34 (8–97)</td> <td>4 (&lt;3–26)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Origin</th> <th>mAb</th> <th>Synovial fluid</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>CD4+ cells</td> <td>CD4</td> <td>191 (&lt;10–711)</td> </tr> <tr> <th>1</th> <td>CD8+ cells</td> <td>CD8</td> <td>&lt;10 (&lt;10–331)</td> </tr> <tr> <th>2</th> <td>Monocytic cells</td> <td>CD14</td> <td>1,315 (57–13,326)</td> </tr> <tr> <th>3</th> <td>B-cells</td> <td>CD20</td> <td>&lt;10 (&lt;10–104)</td> </tr> <tr> <th>4</th> <td>Platelets</td> <td>CD61</td> <td>&lt;10 (&lt;10–17)</td> </tr> <tr> <th>5</th> <td>Erythrocytes</td> <td>Glycophorin A</td> <td>&lt;10 (&lt;10–3,104)</td> </tr> <tr> <th>6</th> <td>Granulocytes</td> <td>CD66e</td> <td>2,380 (&lt;10–20,864)</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Target</th> <th>Forward primer</th> <th>Probe</th> <th>Reverse primer</th> <th>Threshold</th> </tr> </thead> <tbody> <tr> <th>0</th> <td>GAPDH</td> <td>PDAR</td> <td>PDAR</td> <td>PDAR</td> <td>0.047</td> </tr> <tr> <th>1</th> <td>Collagen type I</td> <td>5' CAG CCG CTT CAC CTA CAG C 3'</td> <td>5' CCG GTG TGA CTC GTG CAG CCA TC 3'</td> <td>5' TTT TGT ATT CAA TCA CTG TCT TGC C 3'</td> <td>0.078</td> </tr> <tr> <th>2</th> <td>Collagen type II</td> <td>5' GGC AAT AGC AGG TTC ACG TAC A 3'</td> <td>5' CCG GTA TGT TTC GTG CAG CCA TCC T 3'</td> <td>5' CGA TAA CAG TCT TGC CCC ACT T 3'</td> <td>0.100</td> </tr> <tr> <th>3</th> <td>Aggrecan</td> <td>5' TCG AGG ACA GCG AGG CC 3'</td> <td>5' ATG GAA CAC GAT GCC TTT CAC CAC GA 3'</td> <td>5' TCG AGG GTG TAG CGT GTA GAG A 3'</td> <td>0.050</td> </tr> <tr> <th>4</th> <td>SOX9</td> <td>5' GAC TTC CGC GAC GTG GAC 3'</td> <td>5' CGA CGT CAT CTC CAA CAT CGA GAC 3'</td> <td>5' GTT GGG CGG CAG GTA CTG 3'</td> <td>0.0562</td> </tr> <tr> <th>5</th> <td>SOX6</td> <td>5' CCG TGA GAT AAT GAC CAG TGT TAC TT 3'</td> <td>5' AAC CCC AGA GCG CCG CAA A 3'</td> <td>5' GTC CAC CAC ATC GGC AAG AC 3'</td> <td>0.052</td> </tr> <tr> <th>6</th> <td>IL-1α</td> <td>PDAR</td> <td>PDAR</td> <td>PDAR</td> <td>0.107</td> </tr> <tr> <th>7</th> <td>IL-1β</td> <td>PDAR</td> <td>PDAR</td> <td>PDAR</td> <td>0.122</td> </tr> <tr> <th>8</th> <td>IL-1Ra</td> <td>5' CCT GCA GGG CCA AGC A 3'</td> <td>5' AGC CTC GCT CTT GGC AGG TAC TCA GT 3'</td> <td>5' GCA CCC AAC ATA TAC AGC ATT CA 3'</td> <td>0.122</td> </tr> <tr> <th>9</th> <td>IL-1RI</td> <td>5' ATT TCT GGC TTC TAG TCT GGT GTT C 3'</td> <td>5' ACT TGA TTT CAG GTC AAT AAC GGT CCC C 3'</td> <td>5' AAC GTG CCA GTG TGG AGT GA 3'</td> <td>0.163</td> </tr> <tr> <th>10</th> <td>MMP-3</td> <td>5' TGA AGA GTC TTC CAA TCC TAC TGT TG 3'</td> <td>5' CGT GGC AGT TTG CTC AGC CTA TCC AT 3'</td> <td>5' CTA GAT ATT TCT GAA CAA GGT TCA TGC A 3'</td> <td>0.108</td> </tr> <tr> <th>11</th> <td>MMP-9</td> <td>5' CCC GGA GTG AGT TGA ACC A 3'</td> <td>5' CCA AGT GGG CTA CGT GAC CTA TGA CAT CC 3'</td> <td>5' CAG GAC GGG AGC CCT AGT C 3'</td> <td>0.041</td> </tr> <tr> <th>12</th> <td>MMP-13</td> <td>5' GGA CAA GTA GTT CCA AAG GCT ACA A 3'</td> <td>5' CTC CAA GGA CCC TGG AGC ACT CAT GTT 3'</td> <td>5' CTT TTG CCG GTG TAG GTG TAG ATA G 3'</td> <td>0.108</td> </tr> <tr> <th>13</th> <td>ADAMTS-4</td> <td>5' ACT GGT GGT GGC AGA TGA CA 3'</td> <td>5' ATG GCC GCA TTC CAC GGT G 3'</td> <td>5' TCA CTG TTA GCA GGT AGC GCT TT 3'</td> <td>0.052</td> </tr> <tr> <th>14</th> <td>ADAMTS-5</td> <td>5' GGA CCT ACC ACG AAA GCA GAT C 3'</td> <td>5' CCC AGG ACA GAC CTA CGA TGC CAC C 3'</td> <td>5' GCC GGG ACA CAC GGA GTA 3'</td> <td>0.122</td> </tr> </tbody> </table>

<table border="1" class="dataframe"> <thead> <tr> <th></th> <th>Target</th> <th>General trend</th> <th>Tissues affected</th> <th></th> <th>Significant changesa (P &lt; 0.05)</th> </tr> </thead> <tbody> <tr> <th>0</th> <td></td> <td></td> <td>Origin of cells</td> <td>Disease state</td> <td></td> </tr> <tr> <th>1</th> <td>MMP-3</td> <td>Increase (5- to 10-fold)</td> <td>NP, AF</td> <td>N, D</td> <td>Non-degenerate NP and AF</td> </tr> <tr> <th>2</th> <td>MMP-13</td> <td>Increase (5- to 10-fold)</td> <td>NP</td> <td>N, D</td> <td>Non-degenerate NP</td> </tr> <tr> <th>3</th> <td>ADAMTS-4</td> <td>Increase (8-fold)</td> <td>NP</td> <td>D</td> <td>Degenerate NP</td> </tr> <tr> <th>4</th> <td>ADAMTS-5</td> <td>No real trend</td> <td>-</td> <td>-</td> <td>None</td> </tr> <tr> <th>5</th> <td>SOX6</td> <td>Decrease (3- to 9-fold)</td> <td>NP, AF</td> <td>N</td> <td>Non-degenerate NP</td> </tr> <tr> <th>6</th> <td>SOX9</td> <td>Decrease (3-fold)</td> <td>NP, AF</td> <td>N</td> <td>None</td> </tr> <tr> <th>7</th> <td>Collagen I</td> <td>Decrease (5- to 10-fold)</td> <td>NP, AF</td> <td>N, D</td> <td>Degenerate NP</td> </tr> <tr> <th>8</th> <td>Collagen II</td> <td>Decrease (5- to 50-fold)</td> <td>AF</td> <td>N, D</td> <td>None</td> </tr> <tr> <th>9</th> <td>Aggrecan</td> <td>Decrease (3- to 7-fold)</td> <td>NP, AF</td> <td>N, D</td> <td>Non-degenerate NP and AF</td> </tr> <tr> <th>10</th> <td>IL-1α</td> <td>Increase (100-fold)</td> <td>NP, AF</td> <td>D</td> <td>Degenerate NP</td> </tr> <tr> <th>11</th> <td>IL-1β</td> <td>Increase (100-fold)</td> <td>NP, AF</td> <td>D</td> <td>Degenerate NP</td> </tr> <tr> <th>12</th> <td>IL-1Ra</td> <td>No real trend</td> <td>-</td> <td>-</td> <td>None</td> </tr> <tr> <th>13</th> <td>IL-1RI</td> <td>Decrease (2- to 10-fold)</td> <td>NP, AF</td> <td>N</td> <td>None</td> </tr> </tbody> </table>