Desktop + Laptop, or just Laptop?
amatheus: I have a desktop and a notebook. I put my personal projects on Dropbox, plus some other things, use imap with Mail, rss with NetNewswire, so everything syncs and it works really well - I get the mobility when I need but use the desktop at home (I don't think I could stand using a notebook at home).
I think you could have problems if you use applications you can't sync between the too, or projects with really large files that are hard to sync.
My only gripe with my setup is browsing; I'm working (well, sort of, when I have time) at some utility to save snapshots of my tabs and send them between the computers, so I can close the notebook with tabs open and get the same tabs on the desktop.