What do you want to be able to customize?
froo: I think it might be interesting to see some sort of user-voted category system so that people who aren't interested in certain topics can filter them.Conversely, if someone was more interested in one topic at any particular time (eg, depending on mood) they can instantly grab all topics in that category without having to trawl through the whole site.But that's not really a personalised customisation thing.Another thing might be the ability to grab someone's "about" box just by hovering the mouse over their username (when reading the comments on an article) - so you can get some more perspective on their point of view without necessarily leaving the page. That would be something I'd personally like to see.