Do you buy related domains early on (.net, .org, similar spellings)?
petesalty: I used to buy all of them but these days I usually go .com, .net and .org. I'll also do any spellings that I think are useful. For example, I have a Twitter app that uses a bot under the username glu. I was originally going to call the app gluenote but I thought people might have an easier time with the name if it was directly related to the Twitter name so I got both gluenote and glunote. It turned out to be a good decision. For the $8 I think it's worth it.