Bet the farm. Python or PHP?
jrockway: Why throw away Perl?  You already know Perl, and Perl has lots of things that PHP and Python don't.  Before you ditch Perl, look at DBIx::Class, Moose, and Catalyst.  And the other 10,000 libraries on CPAN.Then look at the 500 or so libraries available for PHP.Perl has a really insane library culture, and it's very hard to give that up.  I like the syntax of other languages better (Lisp is my favorite), but it's hard to give up the millions of hours of free work called the CPAN.  Perl also has great tools for testing (see how many Test:: modules there are), and it has a culture of testing.  So the libraries you download from the CPAN aren't some untested i-hacked-it-together-while-drunk snippets of code; they're all very carefully tested.  What it boils down to is that when you move your app from development to production, you'll be reasonably sure that your libraries (and app) still work.One line summary: Perl has more features and libraries than the alternatives, and you already know it!  I think the choice is a no-brainer.