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] | LA's Totally Awesome Products - FAQs Let surface dry and then set it back up for the pet. Return the pet to the room. Are LA’s Totally Awesome All Purpose Cleaner ® containers recyclable? Please refer to the logo on the container. With a little bit of care much plastic can be recycled, and collection of plastics for recycling is increasing rapidly. The plastic industry has responded to this problem by developing a series of cryptic markers, commonly seen on the bottom of plastic containers. These markers do not mean the plastic can be recycled, these makers do not mean the container uses recycled plastic. You should place in your bin only those types of plastic listed by your local recycling agency! What is the shelf life of your products? All of our products are tested for a shelf life of a minimum of two years from the date of manufacture. | http://004f876.netsolhost.com/html/faqs.html |
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] | LA's Totally Awesome Products - FAQs The plastic industry has responded to this problem by developing a series of cryptic markers, commonly seen on the bottom of plastic containers. These markers do not mean the plastic can be recycled, these makers do not mean the container uses recycled plastic. You should place in your bin only those types of plastic listed by your local recycling agency! What is the shelf life of your products? All of our products are tested for a shelf life of a minimum of two years from the date of manufacture. However, we do recommend using the product within one year of opening it to guarantee freshness and efficacy. What is LA’s Totally Awesome All Purpose Cleaner ® made from? LA’s Totally Awesome All Purpose Cleaner ® is a blend of water, surfactant (surface-active) agents, color and scent. Surfactant agents lift grease and oil up off of the surface. LA’s Totally Awesome All Purpose Cleaner ® is a safe, naturally gentle soap, specially formulated for cleaning a variety of surfaces like floors, furniture, and other household surfaces. | http://004f876.netsolhost.com/html/faqs.html |
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] | LA's Totally Awesome Products - FAQs However, we do recommend using the product within one year of opening it to guarantee freshness and efficacy. What is LA’s Totally Awesome All Purpose Cleaner ® made from? LA’s Totally Awesome All Purpose Cleaner ® is a blend of water, surfactant (surface-active) agents, color and scent. Surfactant agents lift grease and oil up off of the surface. LA’s Totally Awesome All Purpose Cleaner ® is a safe, naturally gentle soap, specially formulated for cleaning a variety of surfaces like floors, furniture, and other household surfaces. And it leaves your home smelling fresh and clean. LA’s Totally Awesome All Purpose Cleaner ® contains no harsh detergents, ammonia, or bleach. Why aren't the ingredients listed on the label? LA’s Totally Awesome All Purpose Cleaner ® is non-toxic. Therefore, the listing of ingredients on the label is not required by law. | http://004f876.netsolhost.com/html/faqs.html |
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] | LA's Totally Awesome Products - FAQs And it leaves your home smelling fresh and clean. LA’s Totally Awesome All Purpose Cleaner ® contains no harsh detergents, ammonia, or bleach. Why aren't the ingredients listed on the label? LA’s Totally Awesome All Purpose Cleaner ® is non-toxic. Therefore, the listing of ingredients on the label is not required by law. LA’s Totally Awesome All Purpose Cleaner ® unique formula is protected under the US Trade Secrecy Act and has been extensively tested to verify the product's credentials. LA’s Totally Awesome All Purpose Cleaner ® complies with all current labeling requirements for ingredient disclosure on cleaning products. If you have an allergy, medical reason, or technical reason for wanting to know if LA’s Totally Awesome All Purpose Cleaner ® contains a particular item, please contact us at 800-482-2875 and we will help you as best we can. I have a LA’s Totally Awesome All Purpose Cleaner ® and I can't seem to get the product to squirt out. Am I doing something wrong? | http://004f876.netsolhost.com/html/faqs.html |
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] | LA's Totally Awesome Products - FAQs LA’s Totally Awesome All Purpose Cleaner ® unique formula is protected under the US Trade Secrecy Act and has been extensively tested to verify the product's credentials. LA’s Totally Awesome All Purpose Cleaner ® complies with all current labeling requirements for ingredient disclosure on cleaning products. If you have an allergy, medical reason, or technical reason for wanting to know if LA’s Totally Awesome All Purpose Cleaner ® contains a particular item, please contact us at 800-482-2875 and we will help you as best we can. I have a LA’s Totally Awesome All Purpose Cleaner ® and I can't seem to get the product to squirt out. Am I doing something wrong? Product may settle during shipment and develop an air pocket so it may take multiple clicks to get the product started. My home is on a septic system. Is it safe to use LA’s Totally Awesome All Purpose Cleaner ® for cleaning tubs and showers? Yes. Under normal household use, LA’s Totally Awesome All Purpose Cleaner ® won't harm the helpful bacterial and enzymes that are used to keep septic systems free-flowing. | http://004f876.netsolhost.com/html/faqs.html |
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] | LA's Totally Awesome Products - FAQs Product may settle during shipment and develop an air pocket so it may take multiple clicks to get the product started. My home is on a septic system. Is it safe to use LA’s Totally Awesome All Purpose Cleaner ® for cleaning tubs and showers? Yes. Under normal household use, LA’s Totally Awesome All Purpose Cleaner ® won't harm the helpful bacterial and enzymes that are used to keep septic systems free-flowing. Is LA’s Totally Awesome All Purpose Cleaner ® a disinfectant? No LA’s Totally Awesome All Purpose Cleaner ® is not a disinfectant. How do I avoid the LA’s Totally Awesome All Purpose Cleaner ® container leaking? We use the best possible plastic for our products, so leaking is very unusual. The container may have been dropped either at the store or at the home. | http://004f876.netsolhost.com/html/faqs.html |
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] | LA's Totally Awesome Products - FAQs Is LA’s Totally Awesome All Purpose Cleaner ® a disinfectant? No LA’s Totally Awesome All Purpose Cleaner ® is not a disinfectant. How do I avoid the LA’s Totally Awesome All Purpose Cleaner ® container leaking? We use the best possible plastic for our products, so leaking is very unusual. The container may have been dropped either at the store or at the home. Also make sure spray end is not damaged and spray/cap is securely tightened. Is LA’s Totally Awesome Oil Soap ® safe for cleaning wood floors? Yes, LA’s Totally Awesome Oil Soap ® is safe to use on all finished wood surfaces, such as wood floors. Be sure to use according to label directions. | http://004f876.netsolhost.com/html/faqs.html |
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] | Home - Riverdale High School To Obtain your LICENSE you will need to go to this link: https://dds.georgia.gov/ georgia-licenseid/new- licenseid/how-do-i-class-c- license - guidelines are changing daily so make sure you read thoroughly, schedule an appointment and bring all necessary documentation. Then email [email protected]. us and ask her for your Certificate of enrollment (yes AGAIN). You will need to contact YOUR health teacher with whom you took ADAP class/test with and have them send you your ADAP certificate. COVID 19 Vaccination Flyers
Please be sure to check out the information that CCPS is making available to students, families, and the community. Flyers are available in English | Spanish | Vietnamese
Seniors >>> Class of 2021
HERFF JONES WILL BE HERE!!! Cap and Gown Delivery
March 10 - 3 to 5 pm
April 28 - 2 to 5 pm
Please aim to pick up your regalia on these dates. Otherwise, you'd need to pick them up from the Herff Jones office. If you do not make the pickups on either day and time posted above, you would need to pick up cap and gowns from the Herff Jones office address below. | http://005.clayton.k12.ga.us/ |
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] | Home - Riverdale High School COVID 19 Vaccination Flyers
Please be sure to check out the information that CCPS is making available to students, families, and the community. Flyers are available in English | Spanish | Vietnamese
Seniors >>> Class of 2021
HERFF JONES WILL BE HERE!!! Cap and Gown Delivery
March 10 - 3 to 5 pm
April 28 - 2 to 5 pm
Please aim to pick up your regalia on these dates. Otherwise, you'd need to pick them up from the Herff Jones office. If you do not make the pickups on either day and time posted above, you would need to pick up cap and gowns from the Herff Jones office address below. Herff Jones
4634 Lawrenceville Hwy Suite B
Lilburn, GA 30047
Your Input Matters
Click to download the pdf that has two survey links. Please complete both surveys. Any questions, please contact our Title I Liason
Christie George
[email protected]
DOWNLOAD
Monthly and Weekly Calendar of Activities and Events
Below are links to the monthly and weekly calendar of events and activities. Title I Calendar
April 26-30
Senior Newsletter
Student Handbook
Parents and Students,
Please download the student handbook linked below. There are 3 different versions – English, Spanish, and Vietnamese. | http://005.clayton.k12.ga.us/ |
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] | Home - Riverdale High School Herff Jones
4634 Lawrenceville Hwy Suite B
Lilburn, GA 30047
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April 26-30
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Meal Services Announcement
Breakfast and Lunch is Served! All CCPS students may receivemeals at the school bus stop closest to their home (see CCPS Transportation website) or curbside at the nearest school (9 am – Noon) . Breakfast and lunch meals will be served at the same time. Only CCPS students are eligible to receive meals. | http://005.clayton.k12.ga.us/ |
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] | Home - Riverdale High School StudentID numbers may be required to identify students. Parents/guardians may pick up meals for students. Attendance Matters
Please make sure that documentation related to student absences needs to be emailed or faxed to our attendance clerk – Connie Young. Connie Young, Attendance Clerk
[email protected]
770-473-2905 ex. 505124
770-473-2913 fax
Students will be marked tardy if they are 6 minutes late to their virtual classes. Cameras are required to be on during SEL (social-emotional learning) and Live instruction (20-25 mins). If a teacher is unable to see or no responses are given when called, that will lead to the student being marked absent. Parents and families, please remember to check your parent portal to view your child’s attendance and grades. Online Registration System
Since May 2020, Clayton County Public Schools (CCPS) has been offering anOnlineRegistration
(OLR) process for students who areregisteringfor new/returning students who arenot currently enrolled with CCPS for the 2020-2021 school year. For more information regarding 2020-2021 Online Registration, please view the video at http://youtu.be/cct5TjGH7Twor visit the CCPS website (http://www.clayton.k12.ga.us). | http://005.clayton.k12.ga.us/ |
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] | Home - Riverdale High School Cameras are required to be on during SEL (social-emotional learning) and Live instruction (20-25 mins). If a teacher is unable to see or no responses are given when called, that will lead to the student being marked absent. Parents and families, please remember to check your parent portal to view your child’s attendance and grades. Online Registration System
Since May 2020, Clayton County Public Schools (CCPS) has been offering anOnlineRegistration
(OLR) process for students who areregisteringfor new/returning students who arenot currently enrolled with CCPS for the 2020-2021 school year. For more information regarding 2020-2021 Online Registration, please view the video at http://youtu.be/cct5TjGH7Twor visit the CCPS website (http://www.clayton.k12.ga.us). Registration Central Page
https://www.clayton.k12.ga.us/cms/One.aspx?portalId=54515&pageId=237811
CCPS Withdrawal Request Google Form
For more information about counseling related topics, please visit the counseling page. Online Textbooks and Digital Resources
We are working to make sure that all students and parents have access to textbooks and resources. As info, there are two documents you can reference. The first is the CCPS flyer about available resources. The second provides resources available for our students and parents at RHS. | http://005.clayton.k12.ga.us/ |
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] | Landmark Cases in Special Education Landmark Cases in Special Education
Landmark Cases in Special Education
Details
Created on Wednesday, 30 August 2006 07:24
The first federal laws designed to assist individuals with disabilities date back to the early days of the nation. In 1798, the Fifth Congress passed the first federal law concerned with the care of persons with disabilities ( Braddock, 1987; cited in NICHCY, 1997 ). This law authorized a Maine Hospital Service to provide medical services to sick and disabled seamen. By 1912, this service became known as Public Health Service. However, prior to World War II, there were relatively few federal laws authorizing special benefits for persons with disabilities. Those that existed were intended to address the needs of war veterans with service-connected disabilities. This meant that, for most of our nation's history, schools were allowed to exclude-and often did exclude-certain children, especially those with disabilities. In 1948, only 12% of all children with disabilities received some form of special education. By the early 1950s, special education services and programs were available in school districts, but often, undesirable results occurred. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education However, prior to World War II, there were relatively few federal laws authorizing special benefits for persons with disabilities. Those that existed were intended to address the needs of war veterans with service-connected disabilities. This meant that, for most of our nation's history, schools were allowed to exclude-and often did exclude-certain children, especially those with disabilities. In 1948, only 12% of all children with disabilities received some form of special education. By the early 1950s, special education services and programs were available in school districts, but often, undesirable results occurred. For example, students in special classes were considered unable to perform academic tasks. Consequently, they went to special schools or classes that focused on learning manual skills such as weaving and bead stringing. Although programs existed, it was clear that discrimination was still as strong as ever for those with disabilities in schools. Legislation and court cases to prevent discrimination in education first came to notice in 1954 with the famous case Brown v. Board of Education of Topeka, Kansas. In Brown, the Court ruled that it was illegal practice under the Fourteenth Amendment of the U.S. Constitution to arbitrarily discriminate against any group of people. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education For example, students in special classes were considered unable to perform academic tasks. Consequently, they went to special schools or classes that focused on learning manual skills such as weaving and bead stringing. Although programs existed, it was clear that discrimination was still as strong as ever for those with disabilities in schools. Legislation and court cases to prevent discrimination in education first came to notice in 1954 with the famous case Brown v. Board of Education of Topeka, Kansas. In Brown, the Court ruled that it was illegal practice under the Fourteenth Amendment of the U.S. Constitution to arbitrarily discriminate against any group of people. The Court then applied this principle to the schooling of children, holding that a separate education for African American students is not an equal education. In its famous ruling, separate but equal would no longer be accepted ( 347 U.S. 483 ). Brown set the precedent for future discrimination cases in education. People with disabilities were recognized as another group whose rights had been violated because of arbitrary discrimination. For children, the discrimination occurred because they were denied access to schools due to their disabilities. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education The Court then applied this principle to the schooling of children, holding that a separate education for African American students is not an equal education. In its famous ruling, separate but equal would no longer be accepted ( 347 U.S. 483 ). Brown set the precedent for future discrimination cases in education. People with disabilities were recognized as another group whose rights had been violated because of arbitrary discrimination. For children, the discrimination occurred because they were denied access to schools due to their disabilities. Using Brown as their legal precedent, students with disabilities claimed that their segregation and exclusion from school violated their opportunity for an equal education under the Fourteenth Amendment of the U.S. Constitution -the Equal Protection Clause. If Brown could not segregate by race, then schools should not be able to segregate or otherwise discriminate by ability and disability. In the 1960s, parents began to become advocates for better educational opportunities for their children. Around the same time, many authorities began to agree that segregated special classes were not the most appropriate educational setting for many students with disabilities. By the end of the 1960s, landmark court cases set the stage for enactment of federal laws to protect the rights of children with disabilities and their parents. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education Using Brown as their legal precedent, students with disabilities claimed that their segregation and exclusion from school violated their opportunity for an equal education under the Fourteenth Amendment of the U.S. Constitution -the Equal Protection Clause. If Brown could not segregate by race, then schools should not be able to segregate or otherwise discriminate by ability and disability. In the 1960s, parents began to become advocates for better educational opportunities for their children. Around the same time, many authorities began to agree that segregated special classes were not the most appropriate educational setting for many students with disabilities. By the end of the 1960s, landmark court cases set the stage for enactment of federal laws to protect the rights of children with disabilities and their parents. This section presents an overview of some of the most historical court cases in special education in their order of occurrence. Hobson v. Hansen (1967). In Hobson v. Hansen, a U.S. district court declared that the District of Columbia school tracking system was invalid. However, special classes were allowed, provided that testing procedures were rigorous and that retesting was frequent ( Sattler, 1992 ). Diana v. State Board of Education (1970). | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education This section presents an overview of some of the most historical court cases in special education in their order of occurrence. Hobson v. Hansen (1967). In Hobson v. Hansen, a U.S. district court declared that the District of Columbia school tracking system was invalid. However, special classes were allowed, provided that testing procedures were rigorous and that retesting was frequent ( Sattler, 1992 ). Diana v. State Board of Education (1970). In this case, California was mandated by the Court to correct bias in assessment procedures used with Chinese American and Mexican American students. Diana had three very important holdings that would later influence the enactment of federal special education laws: 1. If a student's primary language was not English, the student had to be tested in both English and his or her primary language. 2. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education In this case, California was mandated by the Court to correct bias in assessment procedures used with Chinese American and Mexican American students. Diana had three very important holdings that would later influence the enactment of federal special education laws: 1. If a student's primary language was not English, the student had to be tested in both English and his or her primary language. 2. Culturally unfair items had to be eliminated from all tests used in the assessment process. 3. If intelligence tests were to be used in the assessment process, they had to be developed to reflect Mexican American culture ( Diana v. State Board of Education, C-70: 37RFT (N.D. Cal., 1970 ). | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education Culturally unfair items had to be eliminated from all tests used in the assessment process. 3. If intelligence tests were to be used in the assessment process, they had to be developed to reflect Mexican American culture ( Diana v. State Board of Education, C-70: 37RFT (N.D. Cal., 1970 ). PARC v. Commonwealth of Pennsylvania (1972). In this case, a U.S. federal court in Pennsylvania ratified a consent agreement assuring that schools may not exclude students who have been classified with mental retardation. Also, the Court mandated that all students must be provided with a free public education. Testimony in this case indicated that all mentally retarded persons are capable of benefiting from an educational program. Some are capable of self-sufficiency and some achieve self-care. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education PARC v. Commonwealth of Pennsylvania (1972). In this case, a U.S. federal court in Pennsylvania ratified a consent agreement assuring that schools may not exclude students who have been classified with mental retardation. Also, the Court mandated that all students must be provided with a free public education. Testimony in this case indicated that all mentally retarded persons are capable of benefiting from an educational program. Some are capable of self-sufficiency and some achieve self-care. It also shows that the earlier the program is started, the more the person will learn. The Commonwealth of Pennsylvania had taken it upon themselves to provide a free public education to all of its children between the ages of six and twenty-one, including exceptional children. This caused the
Commonwealth not to be able to dent any mentally retarded child access to a free public education. It became their responsibility to make this education and training appropriate for the child. Wyatt v. Stickney (1972). | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education It also shows that the earlier the program is started, the more the person will learn. The Commonwealth of Pennsylvania had taken it upon themselves to provide a free public education to all of its children between the ages of six and twenty-one, including exceptional children. This caused the
Commonwealth not to be able to dent any mentally retarded child access to a free public education. It became their responsibility to make this education and training appropriate for the child. Wyatt v. Stickney (1972). In Alabama, a federal court ruled that mentally retarded children in state institutions had a constitutional right to treatment (Wyatt v. Stickney, 344 F. Supp. 387, M.D. Ala 1972). Larry P. V Riles (1972) : Larry P. Was a black student in California, and his complaint led to an
expansion of the ruling in the Diana case. The court ruled that schools are responsible for providing
tests that do not discriminate on the basis of race. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
msmarco_v2.1_doc_00_133351#10_232363 | [
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] | Landmark Cases in Special Education In Alabama, a federal court ruled that mentally retarded children in state institutions had a constitutional right to treatment (Wyatt v. Stickney, 344 F. Supp. 387, M.D. Ala 1972). Larry P. V Riles (1972) : Larry P. Was a black student in California, and his complaint led to an
expansion of the ruling in the Diana case. The court ruled that schools are responsible for providing
tests that do not discriminate on the basis of race. In the class-action case of PASE v. Hannon (1980),
however, the fudge stated he could find little evidence of bias in the test items. The Larry P. Case also
set a precedent for the use of data indicating disproportionate placement of minority groups as prima
facie (sufficient to establish a fact or case unless disproved) evidence of discrimination. However,
subsequent cases have undermined this precedent ( Marshall et a. v. Georgia [1984] and S-I v. Turlington
[1986]). Guadalupe v. Tempe Elementary School (1972). In Arizona, a U.S. district court agreed to a stipulated agreement that children could not be placed in educable mentally retarded classes unless they scored lower than two standard deviations below the population mean on an approved IQ test administered in the child's own language. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education In the class-action case of PASE v. Hannon (1980),
however, the fudge stated he could find little evidence of bias in the test items. The Larry P. Case also
set a precedent for the use of data indicating disproportionate placement of minority groups as prima
facie (sufficient to establish a fact or case unless disproved) evidence of discrimination. However,
subsequent cases have undermined this precedent ( Marshall et a. v. Georgia [1984] and S-I v. Turlington
[1986]). Guadalupe v. Tempe Elementary School (1972). In Arizona, a U.S. district court agreed to a stipulated agreement that children could not be placed in educable mentally retarded classes unless they scored lower than two standard deviations below the population mean on an approved IQ test administered in the child's own language. Guadalupe v. Tempe Elementary School also stipulated that other assessment procedures must be used in addition to intelligence tests, and that parental permission must be obtained for such placements ( Sattler, 1992, p. 779 ). Mills v. Board of Education of District of Columbia (1972). This case set forth future guidelines for federal legislation, including the rights of students with disabilities to have access to a free public education, due process protection, and a mandated requirement to receive special education services regardless of the school district's financial capability ( Mills v. Board of Education of District of Columbia, 348 Supp. 866, CD. DC 1972; | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education Guadalupe v. Tempe Elementary School also stipulated that other assessment procedures must be used in addition to intelligence tests, and that parental permission must be obtained for such placements ( Sattler, 1992, p. 779 ). Mills v. Board of Education of District of Columbia (1972). This case set forth future guidelines for federal legislation, including the rights of students with disabilities to have access to a free public education, due process protection, and a mandated requirement to receive special education services regardless of the school district's financial capability ( Mills v. Board of Education of District of Columbia, 348 Supp. 866, CD. DC 1972; contempt proceedings, EHLR 551:643 CD. DC 1980 ). Lau v. Nichols 1974
This civil rights case was brought by limited-English proficient Chinese students living in San Francisco. The students claimed that they were not receiving special help in school due to their inability to speak
English, help which they argued they were entitled to under Title VI of the Civil Rights Act of 1964 becauseof its ban on educational discrimination on the basis of national origin. Finding that the lack of
linguistically-appropriate accommodations (e.g., educational services in Chinese) effectively denied the
Chinese students equal educational opportunities on the basis of their ethnicity, the Supreme Court in
1974 ruled in favor of the students, thus expanding the rights of limited English proficient students around
the nation. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education contempt proceedings, EHLR 551:643 CD. DC 1980 ). Lau v. Nichols 1974
This civil rights case was brought by limited-English proficient Chinese students living in San Francisco. The students claimed that they were not receiving special help in school due to their inability to speak
English, help which they argued they were entitled to under Title VI of the Civil Rights Act of 1964 becauseof its ban on educational discrimination on the basis of national origin. Finding that the lack of
linguistically-appropriate accommodations (e.g., educational services in Chinese) effectively denied the
Chinese students equal educational opportunities on the basis of their ethnicity, the Supreme Court in
1974 ruled in favor of the students, thus expanding the rights of limited English proficient students around
the nation. Among other things, Lau reflects the now-widely accepted view that one's language is so closely intertwined with one's national origin (the country someone or her ancestors came from) that language-based discrimination is effectively a proxy for national origin discrimination. Lau remains an important decision in the areas of civil rights and language rights, and is frequently relied upon as authority in many cases. ( The San Francisco Unified School District remains covered by the consent decree that was ultimately entered into in the Lau case, and civil rights groups continue to monitor SFUSD 's compliance with that decree.) PASE (Parents in Action on Special Education) v. Joseph P. Hannon (1980). In this case regarding bias in IQ testing, the judge ( Judge Grady in Illinois) found that on the IQ tests he examined, only nine of the 488 test questions were racially biased. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education Among other things, Lau reflects the now-widely accepted view that one's language is so closely intertwined with one's national origin (the country someone or her ancestors came from) that language-based discrimination is effectively a proxy for national origin discrimination. Lau remains an important decision in the areas of civil rights and language rights, and is frequently relied upon as authority in many cases. ( The San Francisco Unified School District remains covered by the consent decree that was ultimately entered into in the Lau case, and civil rights groups continue to monitor SFUSD 's compliance with that decree.) PASE (Parents in Action on Special Education) v. Joseph P. Hannon (1980). In this case regarding bias in IQ testing, the judge ( Judge Grady in Illinois) found that on the IQ tests he examined, only nine of the 488 test questions were racially biased. Consequently, IQ tests were found not to be discriminatory. Furthermore, Judge Grady indicated that clinical judgment also plays a large role in interpreting IQ test results. He stated: " There is no evidence in this record that such misassessments as do occur are the result of racial bias in test items or in any aspect of the assessment process currently in use in the Chicago public school system." Therefore, the decision in PASE resolved some of the controversy about the use of IQ tests for special education classification. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education Consequently, IQ tests were found not to be discriminatory. Furthermore, Judge Grady indicated that clinical judgment also plays a large role in interpreting IQ test results. He stated: " There is no evidence in this record that such misassessments as do occur are the result of racial bias in test items or in any aspect of the assessment process currently in use in the Chicago public school system." Therefore, the decision in PASE resolved some of the controversy about the use of IQ tests for special education classification. As a result, the use of intelligence tests was acceptable in psychoeducational assessment as long as they followed all other procedural safeguards under federal law ( PASE v. Joseph P. Hannon, No. 74 C 3586 N.D. Ill. 1980 ). Luke S. and Hans S. v. Nix et al. ( 1982). In the state of Louisiana, all evaluations had to be completed within a 60-day time period. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Landmark Cases in Special Education As a result, the use of intelligence tests was acceptable in psychoeducational assessment as long as they followed all other procedural safeguards under federal law ( PASE v. Joseph P. Hannon, No. 74 C 3586 N.D. Ill. 1980 ). Luke S. and Hans S. v. Nix et al. ( 1982). In the state of Louisiana, all evaluations had to be completed within a 60-day time period. The plaintiffs in this case argued that thousands of students were not being appropriately ev | http://0051b07.netsolhost.com/index.php/more-info/sdsu/22-sped-651/58-landmark-cases-in-special-education |
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] | Examples and Non-Examples Examples and Non-Examples
Examples and Non-Examples
Details
Created on Tuesday, 14 October 2008 15:17
What are Examples and Non-Examples? Examples and Non-Examples is a tactic that can be used to teach defined concepts: Comprehend level. The tactic involves providing learners with instances that include both Examples and Non-Examples of the defined concepts being taught, and asking them to classify them according to the appropriate concept. Below is an example of how to use Examples and Non-Examples for defined concepts at the K3: Comprehend level: You are teaching students about various Chemical Warfare Agents. The related defined concepts in your lesson are Sarin, VX, Mustard, and Hydrogen Cyanide. You have already used a Concept Frame or Concept Map to teach students the defining characteristics of each concept. You then provide them with a series of instances (Examples) set in battlefield contexts that describe what they would experience if the various agents were being used by the enemy. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Comprehend level: You are teaching students about various Chemical Warfare Agents. The related defined concepts in your lesson are Sarin, VX, Mustard, and Hydrogen Cyanide. You have already used a Concept Frame or Concept Map to teach students the defining characteristics of each concept. You then provide them with a series of instances (Examples) set in battlefield contexts that describe what they would experience if the various agents were being used by the enemy. You do not name the chemical agents in your examples, but instead require students to classify each instance according to the appropriate warfare agent. Why should I use Examples and Non-Examples in my teaching? A defined concept is a concept that is known primarily by its definition rather than by physical characteristics. By stating the definition alone, the learners may not fully comprehend the defined concept. Understanding why Examples are in fact Examples and why Non-Examples are not Examples clears up confusion and leads to deeper understanding of the concepts being taught. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples You do not name the chemical agents in your examples, but instead require students to classify each instance according to the appropriate warfare agent. Why should I use Examples and Non-Examples in my teaching? A defined concept is a concept that is known primarily by its definition rather than by physical characteristics. By stating the definition alone, the learners may not fully comprehend the defined concept. Understanding why Examples are in fact Examples and why Non-Examples are not Examples clears up confusion and leads to deeper understanding of the concepts being taught. Also, having learners classify specific items as Examples or Non-Examples tests learners' ability to classify instances of the defined concepts. Examples and Non-Examples may be used with other tactics such as Venn Diagrams, Concept Maps, Concept Frames, and Mental Images. It is important to note that the instances you develop as Examples and Non-Examples must belong to only one of the defined concepts you are teaching. However, they should not be so obviously an Example of a particular concept that learners do not have to do any thinking. Non-Examples are best when they have some characteristics of an Example. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Also, having learners classify specific items as Examples or Non-Examples tests learners' ability to classify instances of the defined concepts. Examples and Non-Examples may be used with other tactics such as Venn Diagrams, Concept Maps, Concept Frames, and Mental Images. It is important to note that the instances you develop as Examples and Non-Examples must belong to only one of the defined concepts you are teaching. However, they should not be so obviously an Example of a particular concept that learners do not have to do any thinking. Non-Examples are best when they have some characteristics of an Example. When using Non-Examples make sure to point out what characteristics of the Non-Example keep it from being an Example. What are the steps for using Examples and Non-Examples? Steps for using Examples and Non-Examples for defined concepts: Comprehend level: 1. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples When using Non-Examples make sure to point out what characteristics of the Non-Example keep it from being an Example. What are the steps for using Examples and Non-Examples? Steps for using Examples and Non-Examples for defined concepts: Comprehend level: 1. Identify the defined concept for which you want to create Examples and Non-Examples. 2. List out all of the defining characteristics each defined concept must contain. 3. Identify several specific Examples of the concept that contain all of the appropriate defining characteristics. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Identify the defined concept for which you want to create Examples and Non-Examples. 2. List out all of the defining characteristics each defined concept must contain. 3. Identify several specific Examples of the concept that contain all of the appropriate defining characteristics. These will be your Examples. 4. Identify a few specific Non-Examples of the concept that contain some of the defining characteristics, but do not contain all of the appropriate defining characteristics. These will be your Non-Examples. 5. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples These will be your Examples. 4. Identify a few specific Non-Examples of the concept that contain some of the defining characteristics, but do not contain all of the appropriate defining characteristics. These will be your Non-Examples. 5. Be able to explain to learners why the Examples and Non-Examples either illustrate or do not illustrate the defined concept. 6. Have learners classify the Examples and Non-Examples you created according to the appropriate concept name. What are some class activities that involve Examples and Non-Examples? The following table contains suggestions of activities to use with Examples and Non-Examples for defined concepts at the K3: | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Be able to explain to learners why the Examples and Non-Examples either illustrate or do not illustrate the defined concept. 6. Have learners classify the Examples and Non-Examples you created according to the appropriate concept name. What are some class activities that involve Examples and Non-Examples? The following table contains suggestions of activities to use with Examples and Non-Examples for defined concepts at the K3: Comprehend level. Click on the activity hyperlink for a list of procedures to follow for using the activity. Activity Example or Non-Example? Purpose and Description
The purpose of this activity is to allow students to practice classifying defined concepts. Students are given instances that represent Examples and Non-Examples. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Comprehend level. Click on the activity hyperlink for a list of procedures to follow for using the activity. Activity Example or Non-Example? Purpose and Description
The purpose of this activity is to allow students to practice classifying defined concepts. Students are given instances that represent Examples and Non-Examples. They must correctly name the defined concept described. Format
Class
Preparation and Materials Required
__________________________________________________________________________________________________________
List of Examples and Non-Examples for the defined concepts
Instructor presentation materials
Example and Non-Example Creation
The purpose of this activity is to allow students to practice comprehending the characteristics of the defined concepts by creating Examples and Non-Examples of the defined concepts. Format
Individual
Pairs
Small group
Preparation and Materials Required
Handouts of a list of defined concepts
Student presentation materials
__________________________________________________________________________________________________________
Narrative Generation from Examples and Non-Examples
The purpose of this activity is to allow students to practice and test their understanding of the characteristics of the defined concepts by creating narratives from a list of Examples and Non-Examples that summarize the lesson content. Format
Individual
Pairs
Small group
Preparation and Materials Required
Handouts of Examples and Non-Examples of the defined concepts
_________________________________________________________________________________________________________
Procedures for Example or Non-Example? 1. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples They must correctly name the defined concept described. Format
Class
Preparation and Materials Required
__________________________________________________________________________________________________________
List of Examples and Non-Examples for the defined concepts
Instructor presentation materials
Example and Non-Example Creation
The purpose of this activity is to allow students to practice comprehending the characteristics of the defined concepts by creating Examples and Non-Examples of the defined concepts. Format
Individual
Pairs
Small group
Preparation and Materials Required
Handouts of a list of defined concepts
Student presentation materials
__________________________________________________________________________________________________________
Narrative Generation from Examples and Non-Examples
The purpose of this activity is to allow students to practice and test their understanding of the characteristics of the defined concepts by creating narratives from a list of Examples and Non-Examples that summarize the lesson content. Format
Individual
Pairs
Small group
Preparation and Materials Required
Handouts of Examples and Non-Examples of the defined concepts
_________________________________________________________________________________________________________
Procedures for Example or Non-Example? 1. Explain that the purpose of this activity is to practice comprehending the characteristics of the defined concepts presented by classifying Examples and Non-Examples of the defined concepts. 2. Present a new Example or Non-Example (that has not been previously presented to students) of the defined concept from the list. 3. Have students determine if it is an Example or Non-Example and explain what characteristics make it an Example or Non-Example. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Explain that the purpose of this activity is to practice comprehending the characteristics of the defined concepts presented by classifying Examples and Non-Examples of the defined concepts. 2. Present a new Example or Non-Example (that has not been previously presented to students) of the defined concept from the list. 3. Have students determine if it is an Example or Non-Example and explain what characteristics make it an Example or Non-Example. 4. Provide feedback for the answer. 5. Repeat steps 2-4 until the students have correctly identified every defined concept from the list. 6. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples 4. Provide feedback for the answer. 5. Repeat steps 2-4 until the students have correctly identified every defined concept from the list. 6. Summarize the results of the activity. Procedures for Example and Non-Example Creation
1. Explain that the purpose of this activity is to practice comprehending the characteristics of the defined concepts presented by creating Examples and Non-Examples of the defined concepts. 2. Divide students into pairs or small groups if desired. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Summarize the results of the activity. Procedures for Example and Non-Example Creation
1. Explain that the purpose of this activity is to practice comprehending the characteristics of the defined concepts presented by creating Examples and Non-Examples of the defined concepts. 2. Divide students into pairs or small groups if desired. 3. Hand out the list of defined concepts to students. If handouts are unavailable, you can write the information on the board and have students copy it. 4. Have students create several new Examples and a few new Non-Examples for each defined concept on the list. ( | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples 3. Hand out the list of defined concepts to students. If handouts are unavailable, you can write the information on the board and have students copy it. 4. Have students create several new Examples and a few new Non-Examples for each defined concept on the list. ( Students should not create Examples or Non-Examples that have been previously presented in class.) 5. Have a few students present their Examples and Non-Examples. Other students should classify the Examples according to the correct defined concept. 6. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Students should not create Examples or Non-Examples that have been previously presented in class.) 5. Have a few students present their Examples and Non-Examples. Other students should classify the Examples according to the correct defined concept. 6. Provide feedback. 7. Summarize the results of the activity. 8. ( Note: | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Provide feedback. 7. Summarize the results of the activity. 8. ( Note: Collect the Examples and Non-Examples that students create. You may want to use them in review activities in the current offering of the course, or in the future should you teach the class again.) Procedures for Narrative Generation from Examples and Non-Examples
1. Explain that the purpose of the activity is to practice understanding the characteristics of the defined concepts presented by creating narratives from a list of Examples and Non-Examples that summarize the lesson content. 2. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Collect the Examples and Non-Examples that students create. You may want to use them in review activities in the current offering of the course, or in the future should you teach the class again.) Procedures for Narrative Generation from Examples and Non-Examples
1. Explain that the purpose of the activity is to practice understanding the characteristics of the defined concepts presented by creating narratives from a list of Examples and Non-Examples that summarize the lesson content. 2. Divide students into pairs or small groups if desired. 3. Provide students with handouts of the Examples and Non-Examples. 4. Have students write a narrative discussing the defined concepts and characteristics presented in the Examples and Non-Examples. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Divide students into pairs or small groups if desired. 3. Provide students with handouts of the Examples and Non-Examples. 4. Have students write a narrative discussing the defined concepts and characteristics presented in the Examples and Non-Examples. 5. Have students exchange their narratives with their peers for evaluation. This step can be repeated if desired. 6. After peer review, have students return the narratives to the original student who wrote the narrative. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples 5. Have students exchange their narratives with their peers for evaluation. This step can be repeated if desired. 6. After peer review, have students return the narratives to the original student who wrote the narrative. 7. Encourage class discussion and provide feedback. Ask students to state the common errors they noticed. 8. Summarize the results of the activity. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples 7. Encourage class discussion and provide feedback. Ask students to state the common errors they noticed. 8. Summarize the results of the activity. What kind of media and student materials should I use for Examples and Non-Examples? There are several media and student materials that can be useful when using Examples and Non-Examples for defined concepts at the K3: Comprehend level. The following table contains suggestions for how you can integrate media and student materials into your lesson. Clicking on the hyperlink for each medium in the table will take you to a template (if there is one provided). | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples What kind of media and student materials should I use for Examples and Non-Examples? There are several media and student materials that can be useful when using Examples and Non-Examples for defined concepts at the K3: Comprehend level. The following table contains suggestions for how you can integrate media and student materials into your lesson. Clicking on the hyperlink for each medium in the table will take you to a template (if there is one provided). Suggested IMM
PowerPoint or Overheads
Description and Example (s)
PowerPoint or overheads can be used to present Examples and Non-Examples. Examples: Present a PowerPoint slide that displays a two-column table that lists Examples and Non-Examples of Chemical Warfare Agents. Present a series of PowerPoint slides that describe instances of each type of Warfare agent in a battle context. Have students read and classify each according to its concept name. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Suggested IMM
PowerPoint or Overheads
Description and Example (s)
PowerPoint or overheads can be used to present Examples and Non-Examples. Examples: Present a PowerPoint slide that displays a two-column table that lists Examples and Non-Examples of Chemical Warfare Agents. Present a series of PowerPoint slides that describe instances of each type of Warfare agent in a battle context. Have students read and classify each according to its concept name. Suggested Student Materials
Description and Example (s)
Handouts of Descriptive Text
Handouts of descriptive text can be used by students for review or to create Examples and Non-Examples from as an in-class or homework assignment. Example: Provide students with handouts that highlight key characteristics of Chemical Warfare Agents, and have them create Examples and Non-Examples from it as a homework assignment. Where can I go to learn more about Examples and Non-Examples? Buehl, D. (1996). | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Suggested Student Materials
Description and Example (s)
Handouts of Descriptive Text
Handouts of descriptive text can be used by students for review or to create Examples and Non-Examples from as an in-class or homework assignment. Example: Provide students with handouts that highlight key characteristics of Chemical Warfare Agents, and have them create Examples and Non-Examples from it as a homework assignment. Where can I go to learn more about Examples and Non-Examples? Buehl, D. (1996). Learning by example. Retrieved February 19, 2002, from http://www.weac.org/News/NOV96/readroom.htm
Byrd, P. (1999). Types of examples: Positive, negative, non-, and best. Retrieved February 19, 2002, from http://www.gsu.edu/~wwwesl/issue1/extypes.htm
Fox, S. Comprehending words and ideas: | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Learning by example. Retrieved February 19, 2002, from http://www.weac.org/News/NOV96/readroom.htm
Byrd, P. (1999). Types of examples: Positive, negative, non-, and best. Retrieved February 19, 2002, from http://www.gsu.edu/~wwwesl/issue1/extypes.htm
Fox, S. Comprehending words and ideas: Definitions, examples and non-examples. Retrieved February 19, 2002, from http://www.resourceroom.net/Comprehension/literature/nonexample.htm
Gagne, R., Briggs, L., & Wager, W. (1992). The principles of instructional design. Fort Worth: Harcourt Brace Jovanovich College Publishers. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Examples and Non-Examples Definitions, examples and non-examples. Retrieved February 19, 2002, from http://www.resourceroom.net/Comprehension/literature/nonexample.htm
Gagne, R., Briggs, L., & Wager, W. (1992). The principles of instructional design. Fort Worth: Harcourt Brace Jovanovich College Publishers. Gagne, R., & Medsker, K. (1996). The conditions of learning: Training applications. Fort Worth: Harcourt Brace College Publishers. | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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-0.6059612035751343,
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] | Examples and Non-Examples Gagne, R., & Medsker, K. (1996). The conditions of learning: Training applications. Fort Worth: Harcourt Brace College Publishers. Hayduk, P. (2001). The five axes of the DSM-IV: A self-instructional exercise. Retrieved February 19, 2002, from http://psych.athabascau.ca/html/Psych435/Tut | http://0051b07.netsolhost.com/index.php/more-info/sdsu/23-sped-450/2215-examples-and-non-examples |
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] | Snowboard Stance
Snowboard Stance
The binding setup, or stance, of a snowboard offers an endless variation
in binding angles and positions. Most snowboarders have tried a lot of setups
before choosing a particular one. I have written this article with the
intention of giving solid advice and explaining more about the whyof
different setups. I have also tried to give the source of particular items
whenever possible -- all the information in this article eventually comes from
magazines, the internet and conversations with experienced- and professional
snowboarders. Unfortunately, there exist many different opinions about
snowboard stances and not one of them seems to prevail. In the end, there is no
"best" setup and it still comes down to personal preference. Hopefully, this
article will at least help you to find a setup that fits you well! Have fun,
Daan Leijen. [ mail, www]
Disclaimer: Although I have been very careful
with all the provided information, I don't make any claim whatsoever regarding
the accuracy or safety of anything in this article. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#1_273255 | [
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] | In the end, there is no
"best" setup and it still comes down to personal preference. Hopefully, this
article will at least help you to find a setup that fits you well! Have fun,
Daan Leijen. [ mail, www]
Disclaimer: Although I have been very careful
with all the provided information, I don't make any claim whatsoever regarding
the accuracy or safety of anything in this article. Any item that may appear to
be offering either medical or legal advice is doing neither. Stance angles
The stance anglesare the angles of the bindings with the width of the
board. Normally, you can find these angles on the binding plates. You can
change the angles by unscrewing the binding, turning it and fasten it again. Some (rental) setups have an easy clip system where you can simply push a
button to change the angles. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#2_274330 | [
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] | Any item that may appear to
be offering either medical or legal advice is doing neither. Stance angles
The stance anglesare the angles of the bindings with the width of the
board. Normally, you can find these angles on the binding plates. You can
change the angles by unscrewing the binding, turning it and fasten it again. Some (rental) setups have an easy clip system where you can simply push a
button to change the angles. The angles are normally written like "+21°/+6°",
which means 21 degrees for the front angle and 6 degrees for the back angle. There is no official way of classifying stance angles, but I think that all
sensible setups can basically be categorized into alpine-, forward-, and duckstance. The snowboard styles with the alpine- and forward stance are quite
similar, with both knees and the upper body pointing forward. The snowboard
style with duck stance differs from the previous stances, with the rear knee
pointing backwards and the upper body aligned with the board. All styles have
in common that your body (and especially your knees) should always be in a naturalposition. | http://006fd3a.netsolhost.com/snowboard_stance.html |
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0.5096833109855652,
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0.7182708978652954,
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0.4413808286190033,
1.2841764688491821,
-0.6517077088356018,
0.25932490825653076,
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0.23224987089633942,
0.624569833278656,
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1.1747586727142334,
0.2730526924133301,
1.2741632461547852,
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1.2485496997833252,
-0.12632308900356293,
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0.46123480796813965,
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0.22755767405033112,
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] | The angles are normally written like "+21°/+6°",
which means 21 degrees for the front angle and 6 degrees for the back angle. There is no official way of classifying stance angles, but I think that all
sensible setups can basically be categorized into alpine-, forward-, and duckstance. The snowboard styles with the alpine- and forward stance are quite
similar, with both knees and the upper body pointing forward. The snowboard
style with duck stance differs from the previous stances, with the rear knee
pointing backwards and the upper body aligned with the board. All styles have
in common that your body (and especially your knees) should always be in a naturalposition. For example, the rear angle should never be larger than the front
angle. Needless to say that your knees will have a bad time otherwise. ( This
may seem obvious to you but I have seen people off piste with a setup of
+30°/+40° :-)
Alpine stance
This setup is used for alpine(or race, or carve) boards. These stiff boards are narrow and
have a square tail. These boards are used with hard boots and the stance angles
for this setup are steep: | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#4_277221 | [
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] | For example, the rear angle should never be larger than the front
angle. Needless to say that your knees will have a bad time otherwise. ( This
may seem obvious to you but I have seen people off piste with a setup of
+30°/+40° :-)
Alpine stance
This setup is used for alpine(or race, or carve) boards. These stiff boards are narrow and
have a square tail. These boards are used with hard boots and the stance angles
for this setup are steep: the front and rear angles are anywhere between
+70° and +35° degrees. This style allows for aggressive carving and is thus
well suited for racing contests. The stance on an alpine board is nowadays more
or less determined by the width of the board with respect to your feet (instead
of some fixed angles). In order to maintain good control in short turns, the
difference between the front- and rear angle should be at least 5°. Forward stance
This is the most common stance setup
used on regular freeride- and freestyle boards. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#5_278546 | [
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] | the front and rear angles are anywhere between
+70° and +35° degrees. This style allows for aggressive carving and is thus
well suited for racing contests. The stance on an alpine board is nowadays more
or less determined by the width of the board with respect to your feet (instead
of some fixed angles). In order to maintain good control in short turns, the
difference between the front- and rear angle should be at least 5°. Forward stance
This is the most common stance setup
used on regular freeride- and freestyle boards. The front angle can be between
+40° and +15° degrees and the rear angle anywhere between +30° and 0° degrees. With the resulting snowboard style, both knees point forward and the shoulders
are aligned with the feet. Anatomically, it is a good idea to make the
difference between the front- and rear angle not too large, say, less than 21°
degrees. A common all-mountain setup is +21° on the front and +6° on the rear. A common, more carve oriented, stance is +30°/+15° (and some people say that
this is also a good stance for learning snowboarding). | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#6_280012 | [
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] | The front angle can be between
+40° and +15° degrees and the rear angle anywhere between +30° and 0° degrees. With the resulting snowboard style, both knees point forward and the shoulders
are aligned with the feet. Anatomically, it is a good idea to make the
difference between the front- and rear angle not too large, say, less than 21°
degrees. A common all-mountain setup is +21° on the front and +6° on the rear. A common, more carve oriented, stance is +30°/+15° (and some people say that
this is also a good stance for learning snowboarding). Duck stance
This setup is not so common nowadays
but it is seen frequently in the half-pipe. With duck stance, the front angle
is anywhere between 30° and 0° degrees while the rear angle is negative,
between -1° and -20°. With this snowboard style, the front knee points forward
while the rear knee points backward. The upper body is aligned with the
snowboard. Anatomically, one should keep the difference between both angles
large enough, say, more than 10°, i.e. a 0°/0° degree setup is not very good
for the knees since they are forced to point inward. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#7_281538 | [
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] | Duck stance
This setup is not so common nowadays
but it is seen frequently in the half-pipe. With duck stance, the front angle
is anywhere between 30° and 0° degrees while the rear angle is negative,
between -1° and -20°. With this snowboard style, the front knee points forward
while the rear knee points backward. The upper body is aligned with the
snowboard. Anatomically, one should keep the difference between both angles
large enough, say, more than 10°, i.e. a 0°/0° degree setup is not very good
for the knees since they are forced to point inward. Common setups are "laid
back" +18°/-6° and "mirror" +15°/-15°. What angles are right for me? Alpine boards (with plate bindings)
It is easy if you own an alpine board with hard-boots: use an alpine stance. The
angles on an alpine board are nowadays more or less determined by the width of
your board. | http://006fd3a.netsolhost.com/snowboard_stance.html |
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] | Common setups are "laid
back" +18°/-6° and "mirror" +15°/-15°. What angles are right for me? Alpine boards (with plate bindings)
It is easy if you own an alpine board with hard-boots: use an alpine stance. The
angles on an alpine board are nowadays more or less determined by the width of
your board. A good start setup is to mount the rear binding in such a way that
the toe-side stands slightly out of the board while the heel-side is just on
the edge. This maximizes the pressure that you can exert on the edges of the
board. The front binding is installed with 8° degrees added to the angle of the
rear binding. Later, you can change the angles a little bit to find a stance
that suits you best. Drawing 1 on the right side shows a setup with not enough angle, especially on
the back foot, which often leads to a spin out during backside turns. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#9_283952 | [
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] | A good start setup is to mount the rear binding in such a way that
the toe-side stands slightly out of the board while the heel-side is just on
the edge. This maximizes the pressure that you can exert on the edges of the
board. The front binding is installed with 8° degrees added to the angle of the
rear binding. Later, you can change the angles a little bit to find a stance
that suits you best. Drawing 1 on the right side shows a setup with not enough angle, especially on
the back foot, which often leads to a spin out during backside turns. Drawing 2 shows a setup with too much angle. This makes it harder to do fast
transitions in short and medium sized turns. (drawings by: hot
snowboards)
Regular boards (with soft-boots)
The other 95% of the snowboarders (with soft-boots) should try forward stance or
duck stance. Start with one of the common setups and see what you like the best
(and if you don't like to experiment, just use +21°/+6°). | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#10_285241 | [
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] | Drawing 2 shows a setup with too much angle. This makes it harder to do fast
transitions in short and medium sized turns. (drawings by: hot
snowboards)
Regular boards (with soft-boots)
The other 95% of the snowboarders (with soft-boots) should try forward stance or
duck stance. Start with one of the common setups and see what you like the best
(and if you don't like to experiment, just use +21°/+6°). Once you have found a
stance that feels good, you can vary the angles a little bit (±3°) to fine tune
the setup, although it is hard to feel any difference with these small
angles. The most difficult choice is whether to use forward stance or
duck stance since the resulting snowboard style is fundamentally different. With this choice, we nosedive directly into the endless and almost religious
discussions about ...
To duck or not to duck? The snowboard styles with forward stance and duck stance differ fundamentally
due to the different alignment of the upper body to the board. Currently, the
forward stance is more commonly used and it is a safe and good choice. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#11_286670 | [
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] | Once you have found a
stance that feels good, you can vary the angles a little bit (±3°) to fine tune
the setup, although it is hard to feel any difference with these small
angles. The most difficult choice is whether to use forward stance or
duck stance since the resulting snowboard style is fundamentally different. With this choice, we nosedive directly into the endless and almost religious
discussions about ...
To duck or not to duck? The snowboard styles with forward stance and duck stance differ fundamentally
due to the different alignment of the upper body to the board. Currently, the
forward stance is more commonly used and it is a safe and good choice. A
nice advantage of the forward stance is that you see where you are going
without having to turn your head. With forward stance, you are backed by the
famous Terje Haakonsen (+21°/+9°), who said that this stance is essential to
have stable edge control, and by the 2002 olympic champion Ross Powers who uses
a +21°/+6° setup. The opinions on duck stance are more controversial. Many experienced
snowboarders that I have talked to, advised against duck stance since they got
knee problems. It is believed that a force that is aligned to the board (for
example, the breaking force of a rock on your path) will be bad for the rear
knee. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#12_288392 | [
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] | A
nice advantage of the forward stance is that you see where you are going
without having to turn your head. With forward stance, you are backed by the
famous Terje Haakonsen (+21°/+9°), who said that this stance is essential to
have stable edge control, and by the 2002 olympic champion Ross Powers who uses
a +21°/+6° setup. The opinions on duck stance are more controversial. Many experienced
snowboarders that I have talked to, advised against duck stance since they got
knee problems. It is believed that a force that is aligned to the board (for
example, the breaking force of a rock on your path) will be bad for the rear
knee. I also heard that a Swiss medical article (which I couldn't
locate) reported that there were more rear knee injuries with
snowboarders that used a 0° angle or duck stance -- off course, it might also
be that duck stanced people do more dangerous tricks (or over-estimate their
skills :-). However, there is also a good argument for using duck stance: it is easier (and
more natural) to bend deep through the knees in duck stance. You can easily try
this at home, try to bend deep through your knees when both feet are pointing a
little bit forward and try it again in a duck stance. Since bending through the
knees is crucial to good snowboarding, it might even be the case that duck
stance improves style and is more friendly to your knees and spine. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#13_290217 | [
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] | I also heard that a Swiss medical article (which I couldn't
locate) reported that there were more rear knee injuries with
snowboarders that used a 0° angle or duck stance -- off course, it might also
be that duck stanced people do more dangerous tricks (or over-estimate their
skills :-). However, there is also a good argument for using duck stance: it is easier (and
more natural) to bend deep through the knees in duck stance. You can easily try
this at home, try to bend deep through your knees when both feet are pointing a
little bit forward and try it again in a duck stance. Since bending through the
knees is crucial to good snowboarding, it might even be the case that duck
stance improves style and is more friendly to your knees and spine. I have had
off-piste lessons from three different snowboard guides in France, each of them
having taught snowboarding for more than 7 seasons and all of them used duck
stance. At least one of them used duck since he was getting knee problems with
a forward stance -- as I said, the opinions on duck stance are quite diverse! Other arguments on duck stance are less convincing. A quick survey of the stance
angles of current professional freestyle snowboarders shows that about half of
them use duck stance and some people say the it is easier to ride backwards
(fakie) with duck stance, but this is quite debatable. One word of warning though. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#14_292007 | [
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] | I have had
off-piste lessons from three different snowboard guides in France, each of them
having taught snowboarding for more than 7 seasons and all of them used duck
stance. At least one of them used duck since he was getting knee problems with
a forward stance -- as I said, the opinions on duck stance are quite diverse! Other arguments on duck stance are less convincing. A quick survey of the stance
angles of current professional freestyle snowboarders shows that about half of
them use duck stance and some people say the it is easier to ride backwards
(fakie) with duck stance, but this is quite debatable. One word of warning though. Duck stance isbad for the rear knee when
your technique is wrong. Off course, this is true in general for any stance but
it happens often that people try to point their rear knee forward when standing
in duck stance for the first time. You can easily spot this by looking at your
knees when making a (frontside) turn, or when your rear knee gets tired very
soon. It is essential that you keep your lower body aligned with the board in
this stance and that both knees point in their natural direction -- do not
force your knees into unnatural angles! Stance centering
Stance centeringmeans that your feet should always be centered and
aligned with respect to the width of your board. | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_184219#15_293710 | [
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] | Duck stance isbad for the rear knee when
your technique is wrong. Off course, this is true in general for any stance but
it happens often that people try to point their rear knee forward when standing
in duck stance for the first time. You can easily spot this by looking at your
knees when making a (frontside) turn, or when your rear knee gets tired very
soon. It is essential that you keep your lower body aligned with the board in
this stance and that both knees point in their natural direction -- do not
force your knees into unnatural angles! Stance centering
Stance centeringmeans that your feet should always be centered and
aligned with respect to the width of your board. This is extremely
important -- I once had one of my bindings off-center and it took me at least a
month before I discovered why my turn completions were unstable. When both
bindings are off-center, it is not so bad, but your turns will be inconsistent: short turns on one side, forced turns on the other. A centeredstance on
the other hand, leads to balanced turns and reduces the likelihood of catching
an edge when the board is pointed down the fall line..
The feetshould be centered on the board -- this | http://006fd3a.netsolhost.com/snowboard_stance.html |
msmarco_v2.1_doc_00_209130#0_295254 | [
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] | Open 00J File Open 00J File
Open 00J File
To open 00J file you need to find an application which works with that kind of file. 00J file extension is used by operating systems to recognize files with content of type 00J. Here is some information which will get you started. How to Open 00J file
To see if you have an application which support 00J file format you need to double click on the file. This will either open it with matching application or Windows will suggest you to look for an application for file extension 00J either on web or on local computer. If there is no application on your computer which can open 00J files you need to search on the internet which application can open 00J files. What is 00J File? File extensions help computers locate correct application for specific files. Operating systems will not look into the content of the files to be opened, but instead, it will immediately locate the file extension of the file and locate for associated application that can open 00J files. This helps the computer to organize its functions and work much faster. Most operating systems (Windows) require the use of file extensions, but others do not (Unix). | http://00j.extensionfile.net/ |
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] | Open 00J File What is 00J File? File extensions help computers locate correct application for specific files. Operating systems will not look into the content of the files to be opened, but instead, it will immediately locate the file extension of the file and locate for associated application that can open 00J files. This helps the computer to organize its functions and work much faster. Most operating systems (Windows) require the use of file extensions, but others do not (Unix). These file extensions are also beneficial for us. By simply looking at the filename, we can determine what type of information is stored to that and what applications can open these files. Have you noticed that when your computer acquires an unknown file, it will ask your permission to look for associated program to open it or look for these programs over the Internet? Yes! These file extensions make the work of the computer easy. | http://00j.extensionfile.net/ |
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] | Open 00J File These file extensions are also beneficial for us. By simply looking at the filename, we can determine what type of information is stored to that and what applications can open these files. Have you noticed that when your computer acquires an unknown file, it will ask your permission to look for associated program to open it or look for these programs over the Internet? Yes! These file extensions make the work of the computer easy. Once there is no application associated with the file, then the computer will immediately ask the users assistance to help look for the source files. 00J File Applications
If you know which application opens file extension 00J and it is not mentioned on our site please e-mail us via contact form. For more information on how to open 00J files read other articles on this website. | http://00j.extensionfile.net/ |
msmarco_v2.1_doc_00_211349#0_298973 | [
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] | 01245 - Area Code for Chelmsford
01245.co.uk: A map and local information for the 01245 area code, serving Chelmsford
01245 - Area Code for Chelmsford
01245 - Areacode for Chelmsford
Local Statistics For The 01245 Areacode
Total Postcodes: 4163
Total People: 163190
Total Households: 67517
Total Companies: 9431
Total Area (sq miles): 133
Local places within the 01245 areacode: Braintree
Maldon
Chelmsford Essex
Great Baddow Chelmsford
Essex
Dunmow
Woodham Walter
Broomfield
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] | 9431
Total Area (sq miles): 133
Local places within the 01245 areacode: Braintree
Maldon
Chelmsford Essex
Great Baddow Chelmsford
Essex
Dunmow
Woodham Walter
Broomfield
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© 2021 Copyright: Localcodes. Co. Uk | http://01245.co.uk/ |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics The Cure Tay-Sachs Foundation - Carrier Statistics
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Carrier Statistics
A person can only be affected by Tay-Sachs Disease when two carrier parents pass a Hex-A gene mutation to their child. When two-carrier parents have children, three outcomes are possible. Both parents do not pass the gene mutation to the child ï¿¿ child will be normal. One parent pass the gene mutation to the child but the other does not ï¿¿ child will not suffer from TSD but will be a carrier of the Tay-Sachs gene. Both parents pass the gene mutation to the child. Child will suffer from TSD and depending upon the mutations passed will likely die at a very young age. As we look at these four possible outcome ï¿¿ there is a 25% chance both parents do not pass the gene mutation to the child; a 50% chance one of the parents passes the gene mutations; and a 25% chance both parents pass the gene mutation. See the chart below: | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics Child will suffer from TSD and depending upon the mutations passed will likely die at a very young age. As we look at these four possible outcome ï¿¿ there is a 25% chance both parents do not pass the gene mutation to the child; a 50% chance one of the parents passes the gene mutations; and a 25% chance both parents pass the gene mutation. See the chart below: If only one of the parents is a carrier of the Tay-Sachs gene mutation then only two outcomes are possible: That one parent passes the gene mutation to the child and the child is a carrier of the Tay-Sachs gene
The parent does not pass the gene mutation and the child is normal and not a carrier
A one-carrier family has a 50% chance that no gene mutation is passed and the children are not carriers and a 50% chance the gene mutation is passed and the child is a carrier. A one-carrier family cannot have an affected child. See chart below: What are the chances you are a carrier? | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics If only one of the parents is a carrier of the Tay-Sachs gene mutation then only two outcomes are possible: That one parent passes the gene mutation to the child and the child is a carrier of the Tay-Sachs gene
The parent does not pass the gene mutation and the child is normal and not a carrier
A one-carrier family has a 50% chance that no gene mutation is passed and the children are not carriers and a 50% chance the gene mutation is passed and the child is a carrier. A one-carrier family cannot have an affected child. See chart below: What are the chances you are a carrier? The groups most at risk are eastern Europeans of (Ashkenazi) Jewish decent, French Canadian living near the St. Lawrence River and Louisiana Cajuns. In these populations statistics show that one in every 27 people carried a Tay-Sachs gene mutation. The next highest at risk population is people of Irish-American decent. The carrier rate in that population is one in 50 people carry the Tay-Sachs gene. And finally for everyone in the general population studies have shown there is a one in 250 chance that you carry the Tay-Sachs gene. | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics The groups most at risk are eastern Europeans of (Ashkenazi) Jewish decent, French Canadian living near the St. Lawrence River and Louisiana Cajuns. In these populations statistics show that one in every 27 people carried a Tay-Sachs gene mutation. The next highest at risk population is people of Irish-American decent. The carrier rate in that population is one in 50 people carry the Tay-Sachs gene. And finally for everyone in the general population studies have shown there is a one in 250 chance that you carry the Tay-Sachs gene. In the US alone there are over 1.2 million Tay-Sachs carriers and the vast majority of those people have never heard of the disease. One of the most insidious features of Tay-Sachs disease is it often strikes families with no prior history of the disease. Large and diverse family trees allow the carriers of the Tay-Sachs disease to go without expression for generations until unexpectedly a child is diagnosed and the family submits to carrier testing. How do I know if I am a carrier? A simple blood test can distinguish Tay-Sachs carriers from non-carriers. | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics In the US alone there are over 1.2 million Tay-Sachs carriers and the vast majority of those people have never heard of the disease. One of the most insidious features of Tay-Sachs disease is it often strikes families with no prior history of the disease. Large and diverse family trees allow the carriers of the Tay-Sachs disease to go without expression for generations until unexpectedly a child is diagnosed and the family submits to carrier testing. How do I know if I am a carrier? A simple blood test can distinguish Tay-Sachs carriers from non-carriers. Blood samples can be analyzed by either enzyme assay or DNA studies. The enzyme assay is a biochemical test that measures the level of Hex-A in a person's blood. Carriers have less Hex-A in their body fluid and cells than non-carriers. The NTSAD (referenced below) maintains a listing of certified carrier screening locations - this is not a blood test every hospital is equiped to preform. Since there is currently no treatment or cure for Tay-Sachs disease, it is important that couples in high risk groups undergo genetic testing to determine if they are carriers. | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics Blood samples can be analyzed by either enzyme assay or DNA studies. The enzyme assay is a biochemical test that measures the level of Hex-A in a person's blood. Carriers have less Hex-A in their body fluid and cells than non-carriers. The NTSAD (referenced below) maintains a listing of certified carrier screening locations - this is not a blood test every hospital is equiped to preform. Since there is currently no treatment or cure for Tay-Sachs disease, it is important that couples in high risk groups undergo genetic testing to determine if they are carriers. There are pre-natal tests that can be preformed to see if a fetus is affected by the Tay-Sachs disease, but there is no treatment for affected fetuses. For more information about Tay-Sachs disease and carrier testing: National Tay-Sachs & Allied Diseases Association
2001 Beacon Street, Suite 204
Boston, MA 02135
Toll Free: 800-906-8723
Telephone: 617-277-4463
Fax: | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Carrier Statistics There are pre-natal tests that can be preformed to see if a fetus is affected by the Tay-Sachs disease, but there is no treatment for affected fetuses. For more information about Tay-Sachs disease and carrier testing: National Tay-Sachs & Allied Diseases Association
2001 Beacon Street, Suite 204
Boston, MA 02135
Toll Free: 800-906-8723
Telephone: 617-277-4463
Fax: 617-277-0134
Website: NTSAD | http://019221f.netsolhost.com/carrierstats.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy
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Gene Therapy
The science of gene therapy has been advancing very quickly over the past ten years. The concept of using gene therapy to treat Tay-Sachs disease is to use molecular trucks (vectors also referred to as viral vectors or AAV) to transport one or more therapeutic genes into diseased cells in the brain. Once inside the cells those vectors will direct the production of large amounts of normal Hex A enzyme, which will be distributed throughout the entire brain. This will lead to elimination of lysosomal storage in the brain, and possibly reversal of deficits and resumption of normal neurological development. Tay-Sachs disease is an excellent candidate for gene therapy because: Tay-Sachs is caused by mutations in a single gene (the Hex A gene). Therefore we only need to restore the activity of one enzyme, which can be accomplished by introducting one gene (hexA) or two genes (hexA and hexB simultaneously) since higher levels of HexA can be reached if both hex genes are introduced simultaneously into the target cells. Cells have the ability to take Hex A from outside the cell and absorb it. If we can create Hex A in the brain, the cells are adept at picking it up and using it. The gene therapy work that is most interesting to us is that of the Tay-Sachs Gene Therapy Consortium composed of researchers from seven highly regarded academic institutions (Auburn University, Boston College, Cambridge University, NYU, Massachusetts General Hospital, Harvard Medical School and University of Massachusetts). | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy Tay-Sachs is caused by mutations in a single gene (the Hex A gene). Therefore we only need to restore the activity of one enzyme, which can be accomplished by introducting one gene (hexA) or two genes (hexA and hexB simultaneously) since higher levels of HexA can be reached if both hex genes are introduced simultaneously into the target cells. Cells have the ability to take Hex A from outside the cell and absorb it. If we can create Hex A in the brain, the cells are adept at picking it up and using it. The gene therapy work that is most interesting to us is that of the Tay-Sachs Gene Therapy Consortium composed of researchers from seven highly regarded academic institutions (Auburn University, Boston College, Cambridge University, NYU, Massachusetts General Hospital, Harvard Medical School and University of Massachusetts). Their work as individual scientists has focused on lysosomal storage diseases (LSDs) affecting the brain. These researchers have combined their expertise with the goal of initiating a gene therapy clinical trial for Tay-Sachs disease (and Sandhoff disease) in early 2017. The Consortium's first year of reasearch was funded entirely by private sources (include $300,00 from the CTSF) at a cost of $423,000. But in 2009, the research team was awarded a four year $3.5 million grant from the NIH. The team found wonderful success with small animal models (mice) large animal models (cats) and even a rare breed of Jacob Sheep that where discovered to suffer from Tay-Sachs disease in 2009. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy Their work as individual scientists has focused on lysosomal storage diseases (LSDs) affecting the brain. These researchers have combined their expertise with the goal of initiating a gene therapy clinical trial for Tay-Sachs disease (and Sandhoff disease) in early 2017. The Consortium's first year of reasearch was funded entirely by private sources (include $300,00 from the CTSF) at a cost of $423,000. But in 2009, the research team was awarded a four year $3.5 million grant from the NIH. The team found wonderful success with small animal models (mice) large animal models (cats) and even a rare breed of Jacob Sheep that where discovered to suffer from Tay-Sachs disease in 2009. This first year of research produced unbelievable success in small animal models and vector distribution throughout the brain. The second year of research focus on large animal models - and again the results where spectacular. However, as the team prepared to submit clinical trial request to the FDA in late 2012 - a problem was found. While testing a new vector delivery device that could pinpoint areas of the brain with more percision than ever before - the team found vectors injected into primate brains where causing unwanted symptoms. The primate brains where having and adverse reaction to the vectors. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy This first year of research produced unbelievable success in small animal models and vector distribution throughout the brain. The second year of research focus on large animal models - and again the results where spectacular. However, as the team prepared to submit clinical trial request to the FDA in late 2012 - a problem was found. While testing a new vector delivery device that could pinpoint areas of the brain with more percision than ever before - the team found vectors injected into primate brains where causing unwanted symptoms. The primate brains where having and adverse reaction to the vectors. The finding where a complete suprise and the team determined it could not move forward safely without fully understand why the primate brain reacted differently that the mice, cats and sheep. And most importantly - how would the human brain react! 2013, 2014 and 2015 where dedicated to finding those answers. In late 2015 the TSGT team believes it has created vectors that will not be toxic in primates - and ultimately humans. A new plan was established at a cost of $1,045,000 to move the project to clinical trials in early 2017. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy The finding where a complete suprise and the team determined it could not move forward safely without fully understand why the primate brain reacted differently that the mice, cats and sheep. And most importantly - how would the human brain react! 2013, 2014 and 2015 where dedicated to finding those answers. In late 2015 the TSGT team believes it has created vectors that will not be toxic in primates - and ultimately humans. A new plan was established at a cost of $1,045,000 to move the project to clinical trials in early 2017. The new plan includes expanded testing, vector manufacturing and another Toxicity study all in hopes of gaining FDA approval for clinical trial. The team has gotten guidance from the FDA and believes it is following the "road map" set forth to be approved. Here is how it might work. All the genes of a virus (adeno-associated virus) are removed and replaced with the HexA gene and other non-viral genetic elements necessary to direct production of the enzyme in infected cells. This is what is commonly known as a viral vector because of it is derived from a virus and it can shuttle (vector) genetic information into cells. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy The new plan includes expanded testing, vector manufacturing and another Toxicity study all in hopes of gaining FDA approval for clinical trial. The team has gotten guidance from the FDA and believes it is following the "road map" set forth to be approved. Here is how it might work. All the genes of a virus (adeno-associated virus) are removed and replaced with the HexA gene and other non-viral genetic elements necessary to direct production of the enzyme in infected cells. This is what is commonly known as a viral vector because of it is derived from a virus and it can shuttle (vector) genetic information into cells. The virus vectors carrying a normal HexA gene are then injected into the brain, and infected cells will start make large amounts of active HexA enzyme which is released into the brain. In essence the viral vectors turn brain cells into microfactories of normal enzyme in the brain. Diseased cells throughout the brain pick up this enzyme released from those manufacturing centers and use it to metabolize (recycle) GM2-ganglioside and eliminate this main product stored in their lysosomes. The concept is quite simple, and it has been demonstrated to be highly effective in treating mouse models of different lysosomal storage diseases, including GM2-gangliosidoses. Untreated GM2 mice (Sandhoff disease) die at 3-4 months of age. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy The virus vectors carrying a normal HexA gene are then injected into the brain, and infected cells will start make large amounts of active HexA enzyme which is released into the brain. In essence the viral vectors turn brain cells into microfactories of normal enzyme in the brain. Diseased cells throughout the brain pick up this enzyme released from those manufacturing centers and use it to metabolize (recycle) GM2-ganglioside and eliminate this main product stored in their lysosomes. The concept is quite simple, and it has been demonstrated to be highly effective in treating mouse models of different lysosomal storage diseases, including GM2-gangliosidoses. Untreated GM2 mice (Sandhoff disease) die at 3-4 months of age. Members of the Consortium have shown that animals treated by the approach described above survive up to 2 years. Although treated animals still present movement abnormalities their lifespan has been increased by 8-fold! Click play to start video
Translation of this approach into an effective treatment in humans has considerable challenges: Size - The human brain is ~2000-fold larger than the mouse brain. Complexity The human brain anatomy is considerably different than the mouse. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy Members of the Consortium have shown that animals treated by the approach described above survive up to 2 years. Although treated animals still present movement abnormalities their lifespan has been increased by 8-fold! Click play to start video
Translation of this approach into an effective treatment in humans has considerable challenges: Size - The human brain is ~2000-fold larger than the mouse brain. Complexity The human brain anatomy is considerably different than the mouse. Delivery modality Although it has been relatively easy to treat mice, the targets in the human brain will have to be carefully chosen to minimize risk and at the same time achieve global distribution of enzyme throughout the brain. Timing of treatment Can severely affected patients resume normal development after treatment? Recent experiments in mouse models of LSDs indicate that the earlier the intervention is performed the better the outcome. This raises the question of when it may be too late to alter the course of disease? We know gene therapy works in animals models. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy Delivery modality Although it has been relatively easy to treat mice, the targets in the human brain will have to be carefully chosen to minimize risk and at the same time achieve global distribution of enzyme throughout the brain. Timing of treatment Can severely affected patients resume normal development after treatment? Recent experiments in mouse models of LSDs indicate that the earlier the intervention is performed the better the outcome. This raises the question of when it may be too late to alter the course of disease? We know gene therapy works in animals models. After the primate issues we need to safely upscale to larger animal models and ultimately human trials. The Tay-Sachs Gene Therapy Consortium has a fourteen month plan to prove the theory and develop a clinical trial protocol. Our is the research will meet FDA guidelines for clinical trial. The new plan cost $1,045,000 and does not include the cost of clinical trial - which may cost and additional million. We are hopeful that some of the larger pharmaceutical companies may be interested in funding the research as we near clinical trial. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy After the primate issues we need to safely upscale to larger animal models and ultimately human trials. The Tay-Sachs Gene Therapy Consortium has a fourteen month plan to prove the theory and develop a clinical trial protocol. Our is the research will meet FDA guidelines for clinical trial. The new plan cost $1,045,000 and does not include the cost of clinical trial - which may cost and additional million. We are hopeful that some of the larger pharmaceutical companies may be interested in funding the research as we near clinical trial. One of the real benefits of gene therapy is that if we can prove that this therapeutic approach works in Tay-Sachs, the vectors can be packed with genes that would help other LSD diseases. From what will be learned during this pre-clinical and clinical studies we may be able develop treatments for many other neurological diseases including Parkinson's, Alzheimer's or multiple sclerosis (MS). Ongoing gene therapy trials in Parkinsonï¿¿s patients have already shown hopeful results. To read the detailed Tay-Sachs Gene Therapy Consortium project description ï¿¿ click here. Visit the Tay-Sachs Gene Therapy Consortium website at www.tsgtconsortium.com. | http://019221f.netsolhost.com/gt.shtml |
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] | The Cure Tay-Sachs Foundation - Research Initiatives - Gene Therapy One of the real benefits of gene therapy is that if we can prove that this therapeutic approach works in Tay-Sachs, the vectors can be packed with genes that would help other LSD diseases. From what will be learned during this pre-clinical and clinical studies we may be able develop treatments for many other neurological diseases including Parkinson's, Alzheimer's or multiple sclerosis (MS). Ongoing gene therapy trials in Parkinsonï¿¿s patients have already shown hopeful results. To read the detailed Tay-Sachs Gene Therapy Consortium project description ï¿¿ click here. Visit the Tay-Sachs Gene Therapy Consortium website at www.tsgtconsortium.com. For additional information: Article from February 14, 2008 Edition of Boston College Chronicle
www.pubmedcentral.nih.gov Gene Therapy
Therapy Procedures
Overview of Gene Therapy | http://019221f.netsolhost.com/gt.shtml |
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] | 4 Things To Know About Self-Contained Septic Systems As Waste Treatment Alternatives - Everything You Need To Know About Construction 4 Things To Know About Self-Contained Septic Systems As Waste Treatment Alternatives - Everything You Need To Know About Construction
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4 Things To Know About Self-Contained Septic Systems As Waste Treatment Alternatives
For many homes, having a conventional sewage system is not possible. This is because sewage services do not reach many homes. In these areas, a septic system is needed to treat waste. Depending on the location of your home, you may not be able to install a conventional septic system either. If this is your case, an alternative waste treatment system is needed, such as an aerobatic septic system. These systems have improved over the years, and today, there are even self-contained systems. Here are some of the things that you may want to know before having a self-contained system installed in your home: 1. Reduce Groundwater Contamination
Self-contained septic systems are a type of aerobic septic system that can be installed in your home. The waste is contained in the tanks and does not leave to the environment like with conventional systems. | http://01construction.com/2015/04/21/4-things-to-know-about-self-contained-septic-systems-as-waste-treatment-alternatives/ |
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] | 4 Things To Know About Self-Contained Septic Systems As Waste Treatment Alternatives - Everything You Need To Know About Construction These systems have improved over the years, and today, there are even self-contained systems. Here are some of the things that you may want to know before having a self-contained system installed in your home: 1. Reduce Groundwater Contamination
Self-contained septic systems are a type of aerobic septic system that can be installed in your home. The waste is contained in the tanks and does not leave to the environment like with conventional systems. This means that these systems to not have the problem of contaminating groundwater supplies, which makes them ideal for homes with wells that are used for the main water service. 2. Conserve Water With Recycling Of Treated Water
You can also conserve water with a self-contained septic system. Since these systems are like a miniature sewage treatment plant, the wastewater can often be used for various needs. It can be filtered and use to flush toilets and as irrigation around your home. | http://01construction.com/2015/04/21/4-things-to-know-about-self-contained-septic-systems-as-waste-treatment-alternatives/ |