Datasets:

stilletto

/

peptide_target_residues_affinity

like 0

[INST] Generate new ligand in SMILES that have affinity to this target MNIFEMLRIDEGLRLKIYKDTEGYYEIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVF(Q)(M)GETGVAG(F)T(N)(S)LRMLQQKRWDEAAVNLA(K)(S)(R)(W)YN(Q)TPNRAKRVITTFRTGTWDAY(K) known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](N)C(=O)N[C@H](CCC(O)N[C@@H](CCC[C@@H](N)C(O)O)[C@H](O)N[C@H](C)C(O)O)C(O)O

[INST] Generate new ligand in SMILES that have affinity to this target SIQAEEWYFGKIT(R)RESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@@H](O)[C@H](CC1CCCCC1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IQAEEWYFGKIT(R)RESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV(K)(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@@H](O)[C@H](CC1CCCCC1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target SIQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)ETTKGAY(C)LSVSDFDNAKGLNV(K)(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(C(F)(F)[PH](O)(O)O)CC1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAY(C)LSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(C(F)(F)[PH](O)(O)O)CC1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target DSIQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGA(Y)(C)LSVSDFDNAKGLNV(K)(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@H](O)[C@H](CC1CCC(O[PH](O)(O)O)C(CO)C1)NC(C)O

[INST] Generate new ligand in SMILES that have affinity to this target AEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAY(C)LSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@H](O)[C@H](C[C@@H]1CCC(O[PH](O)(O)O)[C@H](CO)C1)NC(C)O

[INST] Generate new ligand in SMILES that have affinity to this target VTLFVAL(Y)D(Y)EARTEDDLSFHKGEKFQILNSSEGD(W)WEARSLTTGETGYI(P)S(N)(Y)VAPV known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC[NH2+]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCC[NH3+])C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target DSIQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAY(S)LSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@H](O)[C@H](C[C@@H]1CCC(O[PH](O)(O)O)[C@H](CO)C1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target AEEWYFG(K)(I)T(R)RESERLLLNAENPRGTFLV(R)ESE(T)TKGAY(S)LSVSDFDNAKGLNV(K)(H)(Y)KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@H](O)[C@H](C[C@@H]1CCC(O[PH](O)(O)O)[C@H](CO)C1)N[C@@H](C)O,CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)N[C@@H](O)[C@H](CC1CCC(O[PH](O)(O)O)[C@@H](CO)C1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target SIQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)E(T)TKGAYCLSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAYCLSVSDFDNAKGLNV(K)(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)N[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target SIQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)E(T)TKGAYCLSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYI(T)SRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@@H](O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CCC(=O)O)C(=O)N(C)CCCC1CCCC1

[INST] Generate new ligand in SMILES that have affinity to this target IQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAYCLSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYI(T)SRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@@H](O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CCC(=O)O)C(=O)N(C)CCCC1CCCC1

[INST] Generate new ligand in SMILES that have affinity to this target IQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAYCLSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYI(T)SRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCC[C@@H]1CCCN(C(=O)[C@H](CCC(=O)O)N[C@H](O)[C@H](CC2CCC(O[PH](O)(O)O)CC2)N[C@@H](C)O)C1

[INST] Generate new ligand in SMILES that have affinity to this target IQAEEWYFGKIT(R)RESERLLLNAENPRGTFLV(R)E(S)(E)(T)TKGAYCLSVSDFDNAKGLNVK(H)(Y)(K)IRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD(G)LCHRLTTVCP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCCC[C@@H]1CCCN(C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC2CCC(O[PH](O)(O)O)CC2)N[C@@H](C)O)C1

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(Y)TAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRPPWIEQEGPEYWDR(N)TQIFKTNTQT(Y)RE(N)LRIALR(Y)YNQSEAGSHIIQ(R)M(Y)GCDLGPDGRLLRGH(D)QSAYDGKD(Y)IALNEDLSSWTAADTAAQI(T)QR(K)WEAARVAEQ(L)RA(Y)LEGLCVE(W)LRR(Y)LENGKETLQRADPPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPHH known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRPPWIEQEGPEYWD(R)(N)TQ(I)(F)K(T)NTQ(T)(Y)RE(S)LR(N)LRG(Y)YNQSEAGSHIIQ(R)M(Y)GCDLGPDGRLLRGHDQ(S)AYDGKDYIALNEDLSSWTAADTAAQI(T)QRK(W)EAAR(V)AEQ(L)RA(Y)LEGLCVE(W)LRRYLENGKETLQRADPPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)FYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRPPWIEQEGPEYWD(R)(N)TQ(I)FK(T)NTQTYRE(N)LR(I)ALR(Y)YNQSEAGSHIIQ(R)M(Y)GCDLGPDGRLLRGHDQSAYDGKD(Y)IALNEDLSSWTAADTAAQI(T)QRKWEAARVAE(Q)LRA(Y)LEGLCVE(W)LRR(Y)LENGKETLQRADPPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (V)E(G)(E)(V)(Q)(I)(V)(S)TATQTFLATCINGVCWTVYHGAGTR(T)(I)(A)SPKGPVIQMYTNVDQDLVGWPA(P)Q(G)SRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(C)C)[C@@H](C)CC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCC[NH3+])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target PI(T)[A][Y][A](Q)(Q)(T)(R)GLLG(C)II(T)(S)LTGRDKNQV(E)G(E)(V)Q(I)(V)(S)TATQTFLATCINGVCWTVYHGAGT(R)(T)(I)(A)SPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(C)C)[C@@H](C)CC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCC[NH3+])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C=O)C(C)C,CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC[NH3+])NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](N)CCCC[NH3+])C(C)C)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)CCCC[NH3+])[C@@H](C)CC

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDAEIGMSPWQVML(F)RKSP(Q)ELLCGASLISDRWVLTAAHCLL(Y)PP(W)DKNFTENDL(L)VRIGKHS(R)(T)(R)(Y)ERNIE(K)(I)SMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRG(D)A(C)EGD(S)GGPFVMKSPFNNRWYQMGIVS(W)(G)(E)(G)CD(R)DGKYGFYTHVFRLKKWIQKVIDQFGE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)C(O)N[C@H](C=O)CC(C)C,CC(C)C[C@H](NC(O)[C@H](O)CC1CCC(O)CC1)C(=O)N1[C@H](C(O)N[C@H](CO)CCCNC(N)N)C[C@@H]2CC[C@@H](O)C[C@@H]21

[INST] Generate new ligand in SMILES that have affinity to this target PQITLWKRPLVTIKIGGQLKEALL(D)T(G)(A)(D)(D)TVIEEMSLPGRWKPKMI(G)GIGGFIKVRQYDQIIIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target PQITLWK(R)PLVTIKIGGQLKEALL(D)TGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEICGHKAIGTVLVGPTP(V)NIIGRNLLTQIGCTLNF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCC(=O)O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAY(K)NVVGAR(R)SSWRVVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNAAESKVFYLKMKGDYY(R)(Y)LAEVAAGDDKKGIVDQSQQAYQEAFEISKIRLGLA(L)(N)FSVFYYACSLAKTAFDEAIADDSTLIMQLLRDNLTLW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO[PH](O)(O)O)C(O)NCC(=O)NCC(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAY(K)NVVGAR(R)SSWRVVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNAAESKVFYLKMKGDYY(R)(Y)LAEVAAGDDKKGIVDQSQQAYQEAFEISKIRLGLA(L)(N)FSVFYYACSLAKTAFDEAIADDSTLIMQLLRDNLTLW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO[PH](O)(O)O)C(O)NCC(=O)NCC(=O)NCC=O

[INST] Generate new ligand in SMILES that have affinity to this target MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAY(K)NVVGARRSSW(R)VVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYL(K)MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAESYKDSTLIMQ(L)LRDNLTLW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C=O)CCC(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAY(K)NVVGARRSSW(R)VVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYL(K)MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAESYKDSTLIMQ(L)LRDNLTLW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C=O)CCC(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLV(R)IGKHS(R)(T)(R)(Y)ERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETKGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFN(N)(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C=O,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)RKSP(Q)ELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLV(R)IGKHS(R)(T)(R)(Y)ERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETKGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFN(N)(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C=O,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target VQLQQSGAELVRPGASVKLSCTTSGFNIKDI(Y)I(H)WVKQRPEQGLEWIG(R)L(D)PANGYTKYDPKFQGKATITVDTSSNTAYLHLSSLTSEDTAVYYC(D)G(Y)Y(S)(Y)Y(D)M(D)YWGPGTSVTVSSAKTTAPSVYPLAPVCSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(N)=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target DIVMTQSPSSLTVTTGEKVTMTCKSSQSLL(N)S(R)TQKN(Y)LTWYQQKPGQSPKLLIY(W)ASTRESGVPDRFTGSGSGTDFTLSISGVQAEDLAVYYCQN(N)(Y)NYPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(N)=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)(I)(G)(M)S(P)WQVML(F)R(K)SP(Q)ELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS(R)(T)(R)(Y)ERNIE(K)(I)SMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)PV(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKEGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFNN(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)[C@H](O)N[C@@H](CC(C)C)C(=O)O,CC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C=O)[C@@H](C)CC)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLV(R)IGKHS(R)(T)(R)(Y)ERNIE(K)ISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKEGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFNN(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC=O)[C@@H](C)O,CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CO)CC1CCC(OS(O)(O)O)CC1

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)(I)(G)(M)S(P)(W)QVML(F)RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL(L)V(R)IGKHSR(T)R(Y)ERNIE(K)(I)SMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKEGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVM(K)SPFNN(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C[C@H]1CC[C@H](OS(O)(O)O)CC1)C(O)N[C@@H](CC(C)C)C(=O)O,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IKGGLFADIA(S)(H)P(W)QAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVV(R)(T)V(C)LPPADLQLPDWTEC(E)LSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDG(R)(M)TLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H]([NH3+])[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=[NH2+])C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IKGGLFADIA(S)(H)P(W)QAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVV(R)(T)V(C)LPPADLQLPDWTEC(E)LSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDG(R)(M)TLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H]([NH3+])[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=[NH2+])C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)R(K)SPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL(L)VRIGKHSR(T)R(Y)ERNIEK(I)S(M)LEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKEGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFNN(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)[C@H](O)N[C@H](C=O)CC(C)C,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target HVII(Q)AEFYLNPDQSGEFM(F)DFDGDEIFHVDMAKKETVWRLEEFGRF(A)(S)(F)EAQ(G)ALA(N)IAVDKA(N)LE(I)MTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target PRFLEYSTSECHFFNGTERVRYLDR(Y)FHNQEENVRFDSDVGE(F)RAVTELGR(P)(D)AE(Y)(W)NSQKDLLEQ(K)RG(R)VD(N)(Y)CR(H)(N)YG(V)(V)ESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target HHPPSYVAHLASDFGVRVFQQVAQASKDRNVVF(S)PYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTH(T)KG(M)ISNLLGKGAVDQ(L)(T)R(L)(V)(L)VNA(L)(Y)(F)(N)(G)Q(W)KTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELP(Y)HGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQ(E)P(L)(H)(V)(A)(Q)A(L)Q(K)(V)(K)(I)(E)V(N)ESGTAPEEIIMDRPFLFVVRHNPTGTVL(F)MGQVMEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(N)=O)C(C)C)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target SANHLPFFFGNIT(R)EEAEDYLVQGGMSDGLYLL(R)QSRNYLGGFALSVAHGRKAHH(Y)TIERELNGTYA(I)AGGRTHASPADLCHYHSQESD(G)LVCLLKKPFNRPQGVQPKTGPFEDLKE(N)LI(R)EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKIS(R)EESEQIVLIGSKTNGKFLI(R)A(R)DNNGSYALCLLHEGKV(L)(H)(Y)RIDKDKTGKLSI(P)(E)GKKFDTLWQLVEHYSY(K)AD(G)LLRVLTVPCQKI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target SANHLPFFFGNIT(R)EEAEDYLVQGGMSDGLYLL(R)QSRNYLGGFALSVAHGRKAH(H)(Y)TIERELNGTYA(I)AGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKIS(R)EESEQIVLIGSKTNGKFLI(R)A(R)DNNGSYALCLLHEGKVL(H)(Y)(R)IDKDKTGKLS(I)(P)EG(K)KFDTLWQLVEHYSY(K)A(D)(G)L(L)RVLTVPCQKI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target SANHLPFFFGNIT(R)EEAEDYLVQGGMSDGLYLL(R)QSRNYLGGFALSVAHGRKAH(H)(Y)TIERELNGTYAIAG(G)RTHASPADLCHYHSQESD(G)LVCLLKKPFNRPQGVQPKTPQLEKLIATTAHEKMPWFHGKIS(R)EESEQIVLIGSKTNGKFLI(R)A(R)DNNGSYALCLLHEGKVL(H)(Y)(R)IDKDKTGKLS(I)(P)EG(K)KFDTLWQLVEHYSY(K)A(D)(G)L(L)RVLTVPCQKI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target SANHLPFFFGNIT(R)EEAEDYLVQGGMSDGLYLL(R)QSRNYLGGFALSVAHGRKA(H)(H)(Y)TIERELNGTYAIAGGRTHASPADLCHYHSQESD(G)(L)VCLLKKPFNRPQGVQPKTPQLEKLIATTAHEKMPWFHGKIS(R)EESEQIVLIGSKTNGKFLI(R)A(R)DNNGSYALCLLHEGKVL(H)(Y)(R)IDKDKTGKLSIP(E)GKKFDTLWQLVEHYSY(K)A(D)(G)LLRVLTVPCQKI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target SANHLPFFFGNIT(R)EEAEDYLVQGGMSDGLYLL(R)QSRNYLGGFALSVAHGRKA(H)(H)(Y)TIERELNGTYAIAGGRTHASPADLCHYHSQESD(G)LVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKIS(R)EESEQIVLIGSKTNGKFLI(R)A(R)DNNGSYALCLLHEGKV(L)(H)(Y)RIDKDKTGKLSI(P)(E)GKKFDTLWQLVEHYSY(K)AD(G)LLRVLTVPCQKI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target SANHLPFFFGNIT(R)EEAEDYLVQGGMSDGLYLL(R)QSRNYLGGFALSVAHGRKA(H)(H)(Y)TIERELNGTYAIAGGRTHASPADLCHYHSQESD(G)(L)VCLLKKPFNRPQGVQPKTPQLEKLIATTAHEKMPWFHGKIS(R)EESEQIVLIGSKTNGKFLI(R)A(R)DNNGSYALCLLHEGKV(L)(H)(Y)(R)IDKDKTGKLS(I)(P)EGKKFDTLWQLVEHYSY(K)A(D)(G)(L)(L)RVLTVPCQKI known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1CCC(O[PH](O)(O)O)CC1)C(O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(N)=O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)FYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRAPWIEQEGPEYWD(R)(N)TQ(I)(F)K(T)(N)TQ(T)(Y)RE(S)LRNLRG(Y)YNQSEAGSHI(I)Q(R)M(Y)GCDLGPDGRLLRGHDQ(S)AYDGKDYIALNEDLSSWTAADTAAQI(T)QR(K)(W)EAARVAEQLRA(Y)LEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)Cc1ccc(O)cc1)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)FYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRAPWIEQEGPEYWD(R)(N)TQ(I)(F)K(T)(N)TQ(T)(Y)RE(S)LRNLRG(Y)YNQSEAGSHI(I)Q(R)M(Y)GCDLGPDGRLLRGHDQ(S)AYDGKDYIALNEDLSSWTAADTAAQI(T)QR(K)(W)EAARVAEQLRA(Y)LEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)Cc1ccc(O)cc1)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)FYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRAPWIEQEGPEYWD(R)(N)TQ(I)(F)KT(N)TQ(T)(Y)R(E)(S)LRNLRG(Y)YNQSEAGSHIIQ(R)M(Y)GCDLGPDGRLLRGHDQ(S)AYDGKDYIALNEDLSSWTAADTAAQI(T)QR(K)(W)EAARVAEQLRA(Y)LEGLCVE(W)LRR(Y)LENGKETLQRADPPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)Cc1ccc(O)cc1)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVNGEEAVPG(S)(W)P(W)QVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFS(Q)TVS(A)V(C)LPSASDDFAAGTTCVTTGWGLTRY known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C=O)CC(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target NTPDRLQQASLPLLSNTNCKKY(W)GTKIKDAMICAGASGVS(S)C(M)GD(S)GGPLVCKKNGAWTLVGIV(S)(W)(G)(S)(S)TCSTSTPGVYARVTALVNWVQQTLAAN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@H](C=O)Cc1ccc(O)cc1

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDAEIGMSPWQVML(F)RKSP(Q)(E)(L)(L)CGASLISDRWVLTAA(H)CLL(Y)PPWD(K)NFTENDLLVRIGKHS(R)(T)(R)(Y)ERNIE(K)(I)S(M)LEKIYIHPRYNWRE(N)(L)DRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETG(Q)PSVLQVVNLPIVERPVCKDSTR(I)RITDNMFCAGYKPDEGKRG(D)A(C)(E)(G)D(S)GGPFVMKSPFNNRWYQMGIVS(W)(G)E(G)CDRDGKYGFYTHVFRLKKWIQKVIDQFGE known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CN[C@@H](O)C[C@H](CCCNC(N)N)NC(=O)[C@@H]1CCCN1C(O)[C@H](N)CC1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)(I)(G)(M)S(P)(W)QVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETWTANVGKGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFN(N)(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target NLFVAL(Y)DFVASG(D)NTLSITKGEKLRVLGYNHNGE(W)CEAQTKNGQG(W)VPS(N)(Y)ITPVNS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target NLFVAL(Y)DFVASG(D)NTLSITKGEKLRVLGYNHNG(E)(W)CEAQTKNGQG(W)VPS(N)(Y)ITPVNS known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IVCHT(T)(A)TS(P)(I)SAVTCP(P)GENLCYRKMWCDAFCSSR(G)(K)(V)(V)(E)(L)(G)(C)AATCPSKKPYEEVTCCSTDKCNP(H)PKQRPG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]([NH3+])CCCC[NH3+])C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C=O)Cc1ccc(O)cc1

[INST] Generate new ligand in SMILES that have affinity to this target QVKLQESGPAVIKPSQSLSLTCIVSGFSITRTNYCWHWIRQAPGKGLEWMG(R)IC(Y)(E)GSIYYSPSIKSRSTISRDTSLNKFFIQLISVTNEDTAMYYCSREN(H)(M)YETYFDVWGQGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target DIVMTQSPASLVVSLGQRATISCRASESVDS(Y)GKS(F)MHWYQQKPGQPPKVLIYIASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQ(N)(N)(E)(D)PPTFGAGTKLEMRRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)RKSP(Q)E(L)LCGASLISDRWVLTAAHCLLYPPWDKNFTENDL(L)VRIGKHS(R)(T)(R)(Y)ERNIE(K)(I)SMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFNN(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)N)[C@@H](C)O,CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)C(O)N[C@@H](C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IVNGEEA(V)PG(S)(W)P(W)QVSLQDKTGFHFCGGSLINENWVVTAAHCGVTTSDVVVAGEFDQGSSSEKIQKLKIAKVFKNSKYNSLTINNDITLLKLSTAASFS(Q)TVS(A)V(C)LPSASDDFAAGTTCVTTGWGLTRY known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C=O)CC(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target NTPDRLQ(Q)ASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGPLVCKKNGA(W)TLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C=O)CC(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(D)TAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDR(N)TQ(I)FKT(N)TQ(T)(D)R(E)(S)LRN(L)RG(Y)YNQSEAGSHTLQ(S)M(Y)GCDVGPDGRLLRGHNQ(Y)AYDGKDYIALNEDLRSWTAADTAAQI(T)QRK(W)EAARVAE(Q)(D)RA(Y)LEGTCVE(W)LRR(Y)LENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CN)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(D)TAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDR(N)TQIFKT(N)TQ(T)(D)R(E)(S)LR(N)LRG(Y)YNQSEAGSHTLQ(S)M(Y)GCDVGPDGRLLRGHNQ(Y)AYDGKD(Y)IALNEDLRSWTAADTAAQI(T)QRK(W)EAAR(V)AE(Q)(D)RA(Y)LEGTCVE(W)LRR(Y)LENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(D)TAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDR(N)TQ(I)FKT(N)TQ(T)(D)R(E)(S)LR(N)LRG(Y)YNQSEAGSHTLQ(S)M(Y)GCDVGPDGRLLRGHNQ(Y)AYDGKD(Y)IALNEDLRSWTAADTAAQI(T)QRK(W)EAARVAE(Q)(D)RA(Y)LEGTCVEWLRR(Y)LENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(D)TAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDR(N)TQ(I)FKT(N)TQ(T)(D)R(E)(S)LR(N)LRG(Y)YNQSEAGSHTLQ(S)M(Y)GCDVGPDGRLLRGHNQ(Y)AYDGKDYIALNEDLRSWTAADTAAQI(T)QRK(W)EAAR(V)AE(Q)(D)RA(Y)LEGTCVEWLRR(Y)LENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CN)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(D)TAMSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDR(N)TQ(I)FK(T)(N)TQ(T)(D)RE(S)LRNLRG(Y)YNQSEAGSHTLQ(S)M(Y)GCDVGPDGRLLRGHNQYAYDGKD(Y)IALNEDLRSWTAADTAAQI(T)QRK(W)EAAR(V)AE(Q)(D)RA(Y)LEGTCVE(W)LRR(Y)LENGKDTLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@H](CCCC[NH3+])NC(=O)[C@H](CCCC[NH3+])NC(=O)CNC(=O)C[NH3+])C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL(L)V(R)IGKHS(R)(T)(R)(Y)ERNIE(K)(I)S(M)LEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFNN(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)C(O)N[C@H](C=O)CC(C)C,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target FVN(Q)HL(C)GSH(L)VEALYLV(C)GERGFFYTPKT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target FVN(Q)HL(C)GSH(L)VEALYLV(C)GER(G)FFYTPKT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)N(Q)HL(C)GSHLVEALYLV(C)GERGF(F)YTPKT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C,CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C.OC1CCCCC1

[INST] Generate new ligand in SMILES that have affinity to this target F(V)N(Q)(H)L(C)GSHLVEALYLV(C)GERGFFYTPKT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C,CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C.OC1CCCCC1

[INST] Generate new ligand in SMILES that have affinity to this target FVN(Q)HL(C)GSH(L)VEALYLV(C)GERGF(F)YTPKT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)N(Q)HL(C)GSH(L)VEALYLV(C)GERGF(F)YTPKT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target QVKLQESGPAVIKPSQSLSLTCIVSGFSITRT(N)YCWHWIRQAPGKGLEWMG(R)I(C)(Y)EGSIYYSPSIKSRSTISRDTSLNKFFIQLISVTNEDTAMYYCSREN(H)MYE(T)YFDVWGQGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(C)(C)C(O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target DIVMTQSPASLVVSLGQRATISCRASESVDS(Y)GKS(F)MHWYQQKPGQPPKVLIYIASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQ(N)(N)(E)(D)PPTFGAGTKLEMRRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(C)(C)C(O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C=O)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)RKSP(Q)ELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL(L)V(R)IGKHS(R)(T)(R)(Y)ERNIE(K)(I)S(M)LEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETKGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFN(N)(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)[C@@H](O)N[C@H](C=O)CC(C)C,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target IVEGSDA(E)I(G)(M)S(P)(W)QVML(F)RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL(L)V(R)IGKHS(R)(T)R(Y)ERNIEK(I)S(M)LEKIYIHPRYNWRENLDRDIALMKLKKPVAFS(D)YI(H)(P)V(C)LPDRETAASLLQAG(Y)(K)G(R)VTGWGNLKETKGQPSVLQVV(N)LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFV(M)(K)SPFN(N)(R)(W)YQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCC(OS(O)(O)O)CC1)C(O)N[C@H](C=O)CC(C)C,CC[C@H](C)[C@@H](C=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)[C@@H](C)O

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)NQ(H)L(C)GSH(L)VEALYLV(C)GER(G)(F)F(Y)T(P)KT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)NQ(H)L(C)GSH(L)VEALYLV(C)GER(G)(F)F(Y)T(P)KT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)NQ(H)L(C)GSH(L)VEALYLV(C)GER(G)(F)F(Y)T(P)KT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target F(V)NQ(H)L(C)GSH(L)VEALYLV(C)GER(G)(F)F(Y)T(P)KT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)NQ(H)L(C)GSH(L)VEALYLV(C)GER(G)(F)F(Y)T(P)KT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (F)(V)NQHL(C)GSH(L)VEALYLV(C)GER(G)(F)F(Y)T(P)KT known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)C[NH3+])C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(F)TSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDG(E)T(R)(K)(V)KA(H)SQ(T)HRV(D)LGTLRGYYNQSEAGSHTVQRM(Y)GCDVGSDWRFLRGYHQ(Y)AYDGKDYIALKEDLRSWTAADMAAQT(T)KHK(W)EAAH(V)AE(Q)(L)RA(Y)LEGTCVE(W)LRR(Y)LENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@H](C(=O)O)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target (G)(A)(Q)(V)(S)SQKVGAHESTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@@H](O)[C@@H](C=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN

[INST] Generate new ligand in SMILES that have affinity to this target GSHSMR(Y)F(F)TSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDG(E)TR(K)VKAHSQ(T)HR(V)(D)LGTLRG(Y)YNQSEAGSHTVQRM(Y)GCDVGSDWRFLRGYHQ(Y)AYDGKDYIALKEDLRSWTAADMAAQT(T)KH(K)(W)EAAHVAE(Q)(L)RA(Y)LEGTCVE(W)LRR(Y)LENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRW known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target KEVEQNSGPLSVPEGAIASLNCTYSDRGS(Q)(S)FFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVTT(D)(S)WGKLQFGAGTQVVVTPDIQNP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target GVTQTPKFQVLKTGQSMTLQCAQDMNH(E)YMSWYRQDPGMGLRLIHYSVGAGITDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASRPG(L)AGGR(P)EQYFGPGTRLTVTEDLKNVFPPEVAVFLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLYALSSRLRVSATFWQNPRNHFRCQVQFYGLAKPVTQIVSAEAWGRAD known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target SIQAEEWYFGKLG(R)KDAERQLLSFGNPRGTFLI(R)ESETTKGAYSLSIRDWDDMKGDHVK(H)(Y)(K)IRKLDNGGYYI(T)T(R)AQFETLQQLVQHYSERAA(G)(L)SSRLVVPSHK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]([NH3+])CCC(=O)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target SIQAEEWYFGKLG(R)KDAERQLLSFGNPRGTFLI(R)E(S)ETTKGAYSLSIRDWDDMKGDHV(K)(H)(Y)(K)IRKLDNGGYYI(T)T(R)AQFETLQQLVQHYSERAA(G)(L)SSRLVVPSHK known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(O)[C@H](CC1CCC(O[PH](O)(O)O)CC1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]([NH3+])CCC(=O)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target F(V)(N)(Q)(H)(L)(C)GSHLVEA(L)YLV(C)GE(R)(G)(F)(F)YTPKA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC1=O)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target SEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLG(T)GSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGG(E)M(F)SHL(R)RIGRFAEPHARFYAAQIVLTFEYLHSLDLIYRDLKP(E)NLLIDQQGYIQVTDFG(F)AKRVKGRTWT(L)C(G)TP(E)YLAPEIILSKGYNKAVDWWALGVLIY(E)MAAG(Y)(P)PF(F)A(D)QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDD(Y)EEEEIRVSINEKCGKEFTEF known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)O

[INST] Generate new ligand in SMILES that have affinity to this target AASGVATNTPTANDEEYITPVTIGGTTLNLNF(D)TGSADLWVFSTELPASQQSGHSVYNPSATGKELSGYTWSIS(Y)(G)(D)GSSASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDGLLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQQPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTAGSQSGDGFSGIA(D)T(G)(T)(T)LLLLDDSVVSQYYSQVSGAQQDSNAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDGSTCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFAPQA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCO[C@@H](O)C[C@H](O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(O)CC(C)C)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target AASGVATNTPTANDEEYITPVTIGGTTLNLNF(D)TGSADLWVFSTELPASQQSGHSVYNPSATGKELSGYTWSIS(Y)(G)(D)GSSASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDGLLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQQPGVYDFGFIDSSKYTGSLTYTGVDNSQG(F)WSFNVDSYTAGSQSGDGFSGIA(D)T(G)(T)(T)LLLLDDSVVSQYYSQVSGAQQDSNAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDGSTCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFAPQA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CCO[C@@H](O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(O)CC(C)C)C(C)C)C(C)C.OC[C@H]1OC[C@@H](O)[C@@H](O)[C@@H]1O

[INST] Generate new ligand in SMILES that have affinity to this target AASGVATNTPTAND(E)EYITPVTIGGTTLNLNF(D)T(G)SADLWVFSTELPASQQSGHSVYNPSATGKELSGYTWSIS(Y)(G)(D)GSSASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDGLLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQQPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTAGSQSGDGFSGIA(D)T(G)(T)(T)LLLLDDSVVSQYYSQVSGAQQDSNAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDGSTCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFAPQA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CN(C)CO.CNC(O)C(F)(F)C(O)(O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(O)CC(C)C)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target AASGVATNTPTAND(E)EYITPVTIGGTTLNLNF(D)T(G)SADLWVFSTELPASQQSGHSVYNPSATGKELSGYTWSIS(Y)(G)(D)GSSASGNVFTDSVTVGGVTAHGQAVQAAQQISAQFQQDTNNDGLLGLAFSSINTVQPQSQTTFFDTVKSSLAQPLFAVALKHQQPGVYDFGFIDSSKYTGSLTYTGVDNSQGFWSFNVDSYTAGSQSGDGFSGIA(D)T(G)(T)(T)LLLLDDSVVSQYYSQVSGAQQDSNAGGYVFDCSTNLPDFSVSISGYTATVPGSLINYGPSGDGSTCLGGIQSNSGIGFSIFGDIFLKSQYVVFDSDGPQLGFAPQA known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CN(C)CO.CNC(O)C(F)(F)[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(O)CC(C)C)C(C)C)C(C)C

[INST] Generate new ligand in SMILES that have affinity to this target IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAA(H)CYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNT(L)NNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGK(D)(S)(C)(Q)GDSGGPVVCSGKLQGIV(S)(W)(G)S(G)(C)AQKNKP(G)VYTKVCNYVSWIKQTIASN known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]CC[C@@H](C)[C@@H](NC(O)[C@H](O)CC1CCC(O)CC1)C(O)N1[C@H](C(O)NCCCCNC(N)N)C[C@@H]2CC[C@@H](OS(O)(O)O)C[C@@H]21

[INST] Generate new ligand in SMILES that have affinity to this target MEDLIDGIIFAANYLGSTQLLSDKTPSKNV(R)MMQAQEAVSRIKMAQKLMTEVDLFILTQRIKVLNADTQETMMDHPL(R)T(I)(S)(Y)(I)(A)DIGNIVVLMA(R)RRYK(M)ICHVFESEDAQLI(A)(Q)SIGQA(F)SVA(Y)QE(F)LR known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1

[INST] Generate new ligand in SMILES that have affinity to this target IIFAANYLGSTQLLNVRMMQAQEAVSRIKMAQKLATEVDLFILTQRIKVLNADTQETMMDHPL(R)(T)(I)(S)(Y)(I)ADIGNIVVLMA(R)RRYKMICHVFESEDAQLI(A)QSIGQA(F)SVA(Y)QE(F)LRANGINP known contacting residues marked as explained below. Active residues are marked as follows: single occurrence with ( ), double occurrence with [ ], and more than two occurrences with { }. [/INST]C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1