text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
when these antibodies were labeled with 125i , 45 % and 62 % could be bound to their corresponding antigens , igg globulin and thyroglobulin , respectively . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
114,
122
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
127,
140
]
} |
it has been suggested previously that chlorpropamide and other hypoglycemic sulfonylureas interfere with hepatic triglyceride breakdown . | NA | {
"id": "C0008287",
"name": "chlorpropamide",
"pos": [
38,
52
]
} | {
"id": "C0038766",
"name": "sulfonylureas",
"pos": [
76,
89
]
} |
adrenergic agonists competed for the binding sites in an order of potency , [ ( - ) isoproterenol greater than ( - ) epinephrine ( - ) norepinephrine ] , paralleling their order of potency as beta-adrenergic agonists . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
117,
128
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
135,
149
]
} |
a specially designed tablet dosage form of the benzodiazepine clorazepate dipotassium ( tranxene ) was developed for once-a-day administration . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
47,
61
]
} | {
"id": "C0009033",
"name": "clorazepate",
"pos": [
62,
73
]
} |
sputum aspergillus , pulmonary infiltrates , and dual types i and iii skin reactions to aspergillus fumigatus were observed also . | NA | {
"id": "C0004034",
"name": "aspergillus",
"pos": [
7,
18
]
} | {
"id": "C0004037",
"name": "aspergillus fumigatus",
"pos": [
88,
109
]
} |
the technique , which is especially suited for quantitative cytofluormetric studies , involves the generation of formaldehyde gas from dry paraformaldehyde in a closed reaction vessel with the addition of a measured quantity of water . | NA | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
113,
125
]
} | {
"id": "C0070066",
"name": "closed",
"pos": [
161,
167
]
} |
a radioimmunoassay was developed for murine lactoferrin ( lf ) , a non-heme , iron-binding glycoprotein which appears to be a specific biochemical marker of differentiation in several cell types . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
44,
55
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
91,
103
]
} |
the assay was specific for lactoferrin and no cross-reactivity was observed with transferrin , a similar non-heme , iron-binding glycoprotein . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
27,
38
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
129,
141
]
} |
rabbit antisera to gliadin and alpha-gliadin , and high percentage of sera from patients with gluten-induced enteropathy had antibodies that reacted with an internal structure of wheat grains . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
125,
135
]
} |
hemmagglutination-inhibiting antibody was consistently seen in individuals who received potent new york city and lister vaccines , and neutralizing antibody was induced in 82 % -85 % of children in this group who had some evidence of take ( production of hemagglutination-inhibiting antibody or or major reaction ) . | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
135,
156
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
283,
291
]
} |
eighty-two percent responded with hemagglutination-inhibiting antibody at one month , and only 22 % with neutralizing antibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
62,
70
]
} | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
105,
126
]
} |
specific activities of all three amino acids were always higher in proteinuric glomeruli , but there was no difference in the ratio 14c-hydroxyproline/14c-proline . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
136,
150
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
155,
162
]
} |
the human serum protein binding of cephradine , cephalexin , cephalothin , and cefazolin at 37 degrees c. and physiological ph ( 7.4 ) was found to be 13.8 , 12.4 , 71.2 , and 89.2 per cent , respectively . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
35,
45
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
48,
58
]
} |
several aspects of the activation of adenylate cyclase by guanosine 5'-triphosphate ( gtp ) , 5'-guanylylimidodiphosphate ( gpp ( nh ) p ) and bovine parathyroid hormone ( bpth ) have been studied in chick kidney plasma membrane preparations . | NA | {
"id": "C0018353",
"name": "guanosine",
"pos": [
58,
67
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
124,
136
]
} |
gtp ( 10 ( -4 ) mol/l ) , gpp ( nh ) p ( 10 ( -4 ) mol/l ) and bpth ( 10 i.u./ml ) activated adenylate cyclase without any significant time lag . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
26,
38
]
} |
after 5 min of incubation with kidney plasma membranes , gpp ( nh ) p induced a stable state of activation of adenylate cyclase which was not reversible by subsequent addition of gtp . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
57,
69
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
179,
182
]
} |
in pre-incubation studies , gtp did not produce a persistent enzyme activation and did not modify the effect of gpp ( nh ) p added subsequently at the incubation stage . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
28,
31
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
112,
124
]
} |
gpp ( nh ) p produced a stable state of activation of adenylate cyclase which was not inhibited by addition of gtp at the incubation stage . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
0,
12
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
111,
114
]
} |
lack of a direct effect of synthetic salmon calcitonin on luteinizing hormone and thyrotrophin release in anterior pituitary cell cultures . | NA | {
"id": "C0040160",
"name": "thyrotrophin",
"pos": [
82,
94
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
106,
124
]
} |
the proteins prepared directly from the particles give strong multiple immunoprecipitates with antisera specific to 30s and 50s ribosomal proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
128,
146
]
} |
two-dimensional electrophoresis patterns of the proteins from the 'chloramphenicol particles ' strongly resemble those for 30s and 50s ribosomal proteins , i.e . they are predominantly basic low molecular weight proteins , and are dissimilar to the patterns for the soluble proteins of the cell . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
135,
153
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
274,
282
]
} |
the proteins prepared directly from the particles give strong multiple immunoprecipitates with antisera specific to 30s and 50s ribosomal proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
128,
146
]
} |
the respiratory nitrate reductase in intact cells of p. denitrificans appeared to be inacessible to chlorate present in the reaction medium , and it is suggested that the nitrate reductase is orientated on the plasma membrane so that nitrate gains access from the inner ( cytosolic ) face . | NA | {
"id": "C0068800",
"name": "respiratory nitrate reductase",
"pos": [
4,
33
]
} | {
"id": "C0028123",
"name": "nitrate reductase",
"pos": [
171,
188
]
} |
competence and dna uptake occur only in cultures which are near the end of exponential growth , and maximal transformation requires a dna concentration of 100 mug ml-1 . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
15,
18
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
132,
137
]
} |
using aerobic conditions at 30 degrees c , which are commonly used for enterotoxin production , toxin ( 5 mug ml ( -1 ) ) and pleomorphic cells were detected during the exponential phase of the growth cycle . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
71,
82
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
96,
101
]
} |
human growth hormone ( hgh ) radio-immunoassay ( ria ) was adapted for an accurate measurement of immunoreactive hgh concentrations in the csf in different cases of hypothalamic-somatotropin dysfunctions . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
0,
20
]
} | {
"id": "C0037663",
"name": "somatotropin",
"pos": [
178,
190
]
} |
in somatotropin hypersecretion ( acromegaly ) without adenoma suprasellar extension , higher hgh concentrations recorded in csf than in plasma can not be attributed to an anatomical break-down of the csf blood-brain barrier and suggest an active transport process of pituitary hormones to the cns . | NA | {
"id": "C0037663",
"name": "somatotropin",
"pos": [
3,
15
]
} | {
"id": "C0169964",
"name": "hgh",
"pos": [
93,
96
]
} |
fluorine-18-labeled methyl fluoride , ethyl fluoride , and 2-fluoroethanol were prepared from methanol , ethanol , and ethylene glycol , with yields of 20 % , 25 % , and 12 % , respectively . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
94,
102
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
105,
112
]
} |
significant differences in adipose tissue weights were not always accompanied by significant differences in body weights . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
12,
23
]
} | {
"id": "C0005910",
"name": "body weights",
"pos": [
108,
120
]
} |
on the basis of measuring urinary pregnanediol and in vivo conversion from progesterone to urinary pregnanediol and in vivo conversion from progesterone to urinary pregnanediol in each group , the production of progesterone in the body was shown to vary . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
75,
87
]
} | {
"id": "C0033004",
"name": "pregnanediol",
"pos": [
164,
176
]
} |
detailed studies of the biological activity of several analogues of riboflavin in the riboflavin-deficient chick embryo were undertaken to extend our knowledge of the comparative biochemistry of these flavins . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
68,
78
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
201,
208
]
} |
improved protein conversion ( protein fed : protein gained ) was noted when dietary protein levels were increased from 25 % to 35 % ; | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
9,
16
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
76,
91
]
} |
concerning the pathogenesis of biliary atresia , we presume that congenital abnormalities of bile ducts are a basic factor , and additional nonspecific inflammation and bile stasis complete its pathological condition . | NA | {
"id": "C0021368",
"name": "inflammation",
"pos": [
152,
164
]
} | {
"id": "C0030660",
"name": "pathological condition",
"pos": [
194,
216
]
} |
additional significant problems were associated organ injuries , postoperative wound and intra-abdominal sepsis , bleeding diatheses , and late instances of hemobilia . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
114,
122
]
} | {
"id": "C0018994",
"name": "hemobilia",
"pos": [
157,
166
]
} |
the lesions were classified into five groups : pyogenic granuloma , calcifying fibroblastic granuloma , fibrous hyperplasia , peripheral giant cell granuloma and denture hyperplasia . | NA | {
"id": "C0085653",
"name": "pyogenic granuloma",
"pos": [
47,
65
]
} | {
"id": "C0018188",
"name": "granuloma",
"pos": [
148,
157
]
} |
digoxin , the bis- and mono-digitoxosides of digoxigenin and digoxigenin were separated by silica gel thin-layer chromatography using chloroform-ethyl acetate-glacial acetic acid ( 25:25:1 v/v ) and were quantitated by liquid scintillation spectrometry . | NA | {
"id": "C0012265",
"name": "digoxin",
"pos": [
0,
7
]
} | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
61,
72
]
} |
simultaneous high-pressure liquid chromatographic determination of niacin and niacinamide in multivitamin preparations : reversed-phase , ion-pairing approach . | NA | {
"id": "C0027996",
"name": "niacin",
"pos": [
67,
73
]
} | {
"id": "C0028027",
"name": "niacinamide",
"pos": [
78,
89
]
} |
a high-pressure liquid chromatographic procedure for the simultaneous determination of niacin and niacinamide in multivitamin preparations was developed and evaluated . | NA | {
"id": "C0027996",
"name": "niacin",
"pos": [
87,
93
]
} | {
"id": "C0028027",
"name": "niacinamide",
"pos": [
98,
109
]
} |
a study carried out using this method indicated that the iron from a delayed-release capsule and from a ferrous sulfate solution was equally bioavailable . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
57,
61
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
104,
119
]
} |
the extraction of 14c-tryptophan and 14c-hydroxytryptophan ( 5-htp ) from the blood to the brain was measured using an indicator dilution technique . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
22,
32
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
61,
66
]
} |
naloxone alone had no effect on the extraction of either tryptophan or 5-htp but completely blocked the effect of 20 mg/kg of morphine on the extraction of both tryptophan and 5-htp . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
57,
67
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
176,
181
]
} |
in contrast to acute treatment with morphine , the extractions of tryptophan and 5-htp were not significantly altered 48 hours after chronic treatment with morphine . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
66,
76
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
81,
86
]
} |
in rats , equimolar oral doses of [ 14c ] clofibrate and [ 14c ] clofibric acid produced essentially the same profiles of blood levels , tissue distribution and excretion of radioactivity . | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
42,
52
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
65,
79
]
} |
in dogs , the serum contained 40 % more radioactivity after [ 14c ] clofibric acid than after an equimolar oral dose of [ 14c ] clofibrate ; | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
68,
82
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
128,
138
]
} |
the results demonstrate that clofibric acid and clofibrate are metabolically and pharmacologically equivalent in rats , but not in dogs . | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
29,
43
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
48,
58
]
} |
the data are in accordance with the view that the pharmacological activity of clofibrate is due to clofibric acid . | NA | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
78,
88
]
} | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
99,
113
]
} |
an improved elastomer with an optimum balance of mechanical properties , processability , environmental stability , colorability , and esthetics , for use in fabricating extraoral maxillofacial prostheses , was sought , an arylene silicone polymer , polytetramethylsilphenylenesiloxanedimethylsiloxane , was synthesized and formulated as a pourable , viscous , room-temperature-vulcanizing liquid . | NA | {
"id": "C0013766",
"name": "elastomer",
"pos": [
12,
21
]
} | {
"id": "C0032521",
"name": "polymer",
"pos": [
240,
247
]
} |
however , during sexual regression androgen synthesis was drastically reduced in both testicular components , while the production of 20alpha-reduced metabolites of progesterone and 17alpha-hydroxyprogesterone was increased . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
165,
177
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxyprogesterone",
"pos": [
182,
209
]
} |
the content of prostaglandin e in the cultured cell , determined by radioimmunoassay , was about 15-fold higher than that in rat embryo fibroblast cultures grown under similar conditions , and was comparable to the level of prostaglandins found in decidual cells in vivo . | NA | {
"id": "C0033559",
"name": "prostaglandin e",
"pos": [
15,
30
]
} | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
224,
238
]
} |
while thio-seco-hemicholinium 3 ( 11 ) is stable in the presence of acetylcholinesterase and butyrylcholinesterase in h2o at ph 7.4 , acetylthio-seco-hemicholinium-3 ( 12 ) reacts within seconds to form the hemiacetal form of thiohemicholinium-3 ( 16 ) . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
68,
88
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
93,
114
]
} |
the present studies confirm that the flexible benzylisoquinolines 4 and 5 do not adopt the active dopamine conformation and that the rigid aporphines , preferably containing hydroxyl functions at the 10 or 11 positions , are of greater importance in eliciting potent dopamine agonist activity . | NA | {
"id": "C1257875",
"name": "benzylisoquinolines",
"pos": [
46,
65
]
} | {
"id": "C0003606",
"name": "aporphines",
"pos": [
139,
149
]
} |
l1210 leukemic cells of mice were incubated for a period of two generations in the presence of either alpha-methyl- ( +/- ) -ornithine , an inhibitor of ornithine decarboxylase , or methylglyoxal bis ( guanylhydroazone ) , an inhibitor of s-adenosylmethionine decarboxylase . alpha-methyl- ( +/- ) -ornithine produced a 50 % decrease in spermidine levels , reduced putrescine to nondetectable levels , and caused a slight increase in spermine levels of the cells . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
348,
354
]
} | {
"id": "C0034170",
"name": "putrescine",
"pos": [
365,
375
]
} |
l1210 leukemic cells of mice were incubated for a period of two generations in the presence of either alpha-methyl- ( +/- ) -ornithine , an inhibitor of ornithine decarboxylase , or methylglyoxal bis ( guanylhydroazone ) , an inhibitor of s-adenosylmethionine decarboxylase . alpha-methyl- ( +/- ) -ornithine produced a 50 % decrease in spermidine levels , reduced putrescine to nondetectable levels , and caused a slight increase in spermine levels of the cells . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
348,
354
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
443,
449
]
} |
methylglyoxal bis ( guanylhydrazone ) produced a large increase inputrescine levels , the same decrease in spermidine levels as did alpha-methyl- ( +/- ) -ornithine , and approximately a 45 % decrease in spermine levels . | NA | {
"id": "C0037871",
"name": "levels",
"pos": [
77,
83
]
} | {
"id": "C0037874",
"name": "levels",
"pos": [
213,
219
]
} |
the per mole pressor activity of the synthetic decapeptide ( in rats anesthetized with pentobarbital and treated with pentolinium ) as compared to mammalian angiotensins , namely , [ ile5 ] angiotensin i , [ val5 ] angiotensin i , [ ile5 ] angiotensin ii , and [ val5 ] angiotensin ii , was 157 , 181 , 114 , and 85 % , respectively . | NA | {
"id": "C0003018",
"name": "angiotensins",
"pos": [
157,
169
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
270,
283
]
} |
the per mole pressor activity of the synthetic decapeptide ( in rats anesthetized with pentobarbital and treated with pentolinium ) as compared to mammalian angiotensins , namely , [ ile5 ] angiotensin i , [ val5 ] angiotensin i , [ ile5 ] angiotensin ii , and [ val5 ] angiotensin ii , was 157 , 181 , 114 , and 85 % , respectively . | NA | {
"id": "C0003018",
"name": "angiotensins",
"pos": [
157,
169
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
270,
284
]
} |
further evidence for the uniqueness of this antigen was sought by enhancement ( addition of another antigen to the first phase of electrophoresis which increased the size of common peaks ) and suppression ( addition of another antiserum to the second phase , whereby the peak size of components to which both sera have antibody was decreased ) . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
227,
236
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
319,
327
]
} |
an antiserum made in rabbits against this component reacted by radioiodine-labeled antibody assay with an antigen on the surface on cells from hodgkin 's disease cultures that was present in very small amounts , or in a cryptic state , on normal cultured cells . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
3,
12
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
83,
91
]
} |
when this also failed to control the hemorrhage a selective hepatic angiogram showed a false aneurysm in the right lobe of the liver with surrounding hematoma . | NA | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
37,
47
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
150,
158
]
} |
a unique case of a high posterior vertical linear laceration of the pharyngeosophagus secondary to steering wheel trauma without concomitant injury is presented . | NA | {
"id": "C0043246",
"name": "laceration",
"pos": [
50,
60
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
114,
120
]
} |
the nonintegrated infectious viral dna was in the form of either a double-stranded linear dna with a molecular weight of 6 x 10 ( 6 ) , detected in both the cytoplasm and nucleus , or a closed circular dna of the same molecular weight , detected primarily in the nucleus . | NA | {
"id": "C0012939",
"name": "infectious viral dna",
"pos": [
18,
38
]
} | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
67,
82
]
} |
the nonintegrated infectious viral dna was in the form of either a double-stranded linear dna with a molecular weight of 6 x 10 ( 6 ) , detected in both the cytoplasm and nucleus , or a closed circular dna of the same molecular weight , detected primarily in the nucleus . | NA | {
"id": "C0012854",
"name": "double-stranded",
"pos": [
67,
82
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
250,
251
]
} |
( 1974 ) for measuring rates of viral rna synthesis , short-term labeling experiments of a mouse mammary tumor cell line indicate that the glucocorticoid hormone dexamethasone stimulates a 3-fold increase in the synthesis of mmtv-specific rna within 10 min after the addition of hormone and that stimulation of rna synthesis reaches 5- to 10-fold within 30 to 60 min , while the synthesis of moloney leukemia virus-specific rna in the same cell is unaffected by steroids . | NA | {
"id": "C0035736",
"name": "mmtv",
"pos": [
225,
229
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
424,
427
]
} |
the decay rates of pulse-labeled and accumulated mmtv rna in the presence or absence of dexamethasone show this rna to have a half-life of greater than 8 h . | NA | {
"id": "C0035736",
"name": "mmtv rna",
"pos": [
49,
57
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
112,
115
]
} |
in addition , hormone-stimulated mmtv rna appears to have an increased rate of decay compared to basal mmtv rna , thus ruling out an increased stability of mmtv rna in the presence of steroid hormones as the basis for increased rna levels . | NA | {
"id": "C0035736",
"name": "mmtv rna",
"pos": [
33,
41
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
228,
231
]
} |
it has also been shown that the viral rna ( designated alpha rna ) that accumulates in the cytoplasm during cycloheximide treatment and on polyribosomes immediately upon withdrawal of the drug is homologous to 10 to 12 % of viral dna , whereas the viral rna accumulating in the cytoplasm of untreated cells at 8 to 14 h after infection is homologous to 43 % of viral dna ( kozak and roizman , 1974 ) . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
38,
41
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
248,
257
]
} |
however , treatment with neuraminidase or a mixture of glycosidase enzymes , which left the major serological properties of gp71 intact , did not reduce the interference potential of gp71 for flv or akr mulv . | NA | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
25,
38
]
} | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
55,
66
]
} |
in contrast , indirect hemagglutination by gp71 was abolished not only by proteases but also by treatment with glycosidase enzymes , although neuraminidase had no effect . | NA | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
111,
122
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
142,
155
]
} |
nucleotides from degraded infecting viral dna were reincorporated into cell dna that was synthesized during the infection . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
36,
45
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
76,
79
]
} |
in different experiments the amount of new dna , determined by the amount of nucleotide incorporation into an acid-insoluble form , was between 29 and 45 % of the total circular dna isolated from dane particle preparations after the reaction . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
43,
46
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
169,
181
]
} |
results show that b-77 sarcoma virus and rous-associated virus-61 integrate in the unique region of duck dna , whereas b-77 proviral dna is associated with both repeated and unique host dna sequences in transformed mouse 3t3 cells . | NA | {
"id": "C0919262",
"name": "b",
"pos": [
18,
19
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
186,
189
]
} |
part of the fo iii dna molecules contain viral-host dna sequences covalently linked with each other . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
19,
22
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
41,
46
]
} |
h-1 dna was isolated from human or hamster cells infected with a temperature-sensitive mutant , ts1 , which is deficient in progeny single-stranded dna synthesis at the restrictive temperature ( s.l . rhode , 1976 ) , thus minimizing possible confusion between rf and progeny dna replicative intermediates ( ris ) . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
132,
151
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
276,
279
]
} |
women taking ocs had normal factor xii levels , moderately elevated prekallikrein levels , and decreased kallikrein inhibitor levels , a pattern not consistent with activation of the intrinsic pathway . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
68,
81
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
105,
115
]
} |
in contrast , fibrin and fibrinogen degradation products in serum were lower than normal ( p less than .05 ) . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
14,
20
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation products",
"pos": [
25,
56
]
} |
the presence of antinuclear antibodies with speckled pattern is essential for the diagnosis of the sharp syndrome ( moxed connective tissue disease=mctd ) . | NA | {
"id": "C0009782",
"name": "connective tissue disease",
"pos": [
122,
147
]
} | {
"id": "C0026272",
"name": "mctd",
"pos": [
148,
152
]
} |
antinuclear antibodies ( ana ) with speckled pattern can be observed in sera of patients with various rheumatic diseases ( rheumatoid arthritis , systemic lupus erythematosus , sjogren syndrome ) and even in healthy persons . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
123,
143
]
} | {
"id": "C1527336",
"name": "sjogren syndrome",
"pos": [
177,
193
]
} |
of 855 convicted drunken or alcohol-impaired drivers who participated in an alcohol education program , those who needed the program most ( i.e. , the young and those with high blood alcohol concentrations at the time of their arrest ) were most likely to drop out of the program . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
28,
35
]
} | {
"id": "C0684262",
"name": "blood alcohol concentrations",
"pos": [
177,
205
]
} |
half of these deaths were in subjects in whom the findings at initial screening had suggested early myocardial ischaemia ( angina or history of possible infarction according to standard questionnaire , or electrocardiographic evidence of ischaemia ) . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
153,
163
]
} | {
"id": "C0022116",
"name": "ischaemia",
"pos": [
238,
247
]
} |
a number of reports of the literature about metastases of benign pleomorphic adenomas deals with misinterpretations of secondary adenomas in pre-existing pleomorphic adenomas . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
77,
85
]
} | {
"id": "C0026277",
"name": "pleomorphic adenomas",
"pos": [
154,
174
]
} |
( -- ) -hydroxycitrate reduced equivalently the biosynthesis of triglycerides , phospholipids , cholesterol , diglycerides , cholesteryl esters , and free fatty acids in isolated liver cells . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
96,
107
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
125,
143
]
} |
the hypobetalipoproteinemic activity of u-41,792 ( 1- [ p- ( 1-adamantyloxy ) -phenyl ] -piperidine ) is a marked and selective reduction of heparin precipitating lipoproteins ( low density plus very low density lipoproteins ) in cholesterol-cholic acid induced hypercholesterolemic rats . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
163,
175
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
195,
211
]
} |
studies employing vldl and radioactive free fatty acids indicated that the cells took up utlilzed fatty acids derived from these lipoproteins . | NA | {
"id": "C0023825",
"name": "vldl",
"pos": [
18,
22
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
129,
141
]
} |
studies employing vldl and radioactive free fatty acids indicated that the cells took up utlilzed fatty acids derived from these lipoproteins . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
39,
55
]
} | {
"id": "C0015684",
"name": "fatty",
"pos": [
98,
103
]
} |
dissociation of lipoproteins into their respective lipid and protein components significantly reduced their inhibitory titre . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
16,
28
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
51,
56
]
} |
sonication of the three major lipoprotein fractions significantly increased the inhibitory activities of low density lipoproteins ( ldl ) and very low density lipoproteins ( vldl ) but not high density lipoproteins ( hdl ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
30,
41
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
142,
171
]
} |
two prinicipal methods of introducing deuterium were used : preparation of 2,2-dideutero acids by exchange with deuterium oxide followed by chain extension giving dideuteroxooctadecanoates , which were then reduced , as tosylhydrazones , with sodium cyanoborohydride to dideuterooctadecanoates and stepwise introduction by reduction of oxooctadecanoates with sodium borodeuteride , formation of tosylate or mesylate , reduction with lithium aluminum deuteride to tetradeuterooctadecanol and oxidation to dideuterooctadecanoic acid . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
38,
47
]
} | {
"id": "C0011745",
"name": "deuterium oxide",
"pos": [
112,
127
]
} |
single injections of this amino acid increase brain tyrosine levels and accelerate brain catechol synthesis , while injections of a competing neutral amino acid ( e.g. , leucine , tryptophan ) reduce brain tyrosine and its rate of conversion to dopa . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
26,
36
]
} | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
142,
160
]
} |
immediately after ketoacid infusions , plasma branched-chain amino acids , including allosioleucine , rose , while alanine and several other amino acids ( but not glutamine ) fell . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
46,
72
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
141,
152
]
} |
immediately after ketoacid infusions , plasma branched-chain amino acids , including allosioleucine , rose , while alanine and several other amino acids ( but not glutamine ) fell . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
115,
122
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
141,
152
]
} |
in the disordered salt and water metabolism of the obese , persistently high avp values during water loading appeared to be a factor in the delay of water excretion . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
33,
43
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
155,
164
]
} |
animal experiments give evidence of the important role of cardiac arrhythmias , in particular of asystolia and ventricular fibrillation . | NA | {
"id": "C0003811",
"name": "cardiac arrhythmias",
"pos": [
58,
77
]
} | {
"id": "C0042510",
"name": "ventricular",
"pos": [
111,
122
]
} |
in the heritable translocation test 11 % sterile and partially sterile f1 males were observed in 250 offspring of the mms group . | NA | {
"id": "C0021359",
"name": "sterile",
"pos": [
41,
48
]
} | {
"id": "C0021364",
"name": "sterile",
"pos": [
63,
70
]
} |
all of the 14 partially sterile and 6 of the 14 sterile f1 males were demonstrated to be translocation carriers . | NA | {
"id": "C0021359",
"name": "sterile",
"pos": [
24,
31
]
} | {
"id": "C0021364",
"name": "sterile",
"pos": [
48,
55
]
} |
the study was limited to 136 patients with viral hepatitis in wwhich the test for hbsag was effected with ria : of these 58 were hbag+ and 78 hbag- . | NA | {
"id": "C0019168",
"name": "hbsag",
"pos": [
82,
87
]
} | {
"id": "C0019165",
"name": "hbag",
"pos": [
142,
146
]
} |
space is dedicated to the behaviour of hbsag in acute hbag+ hepatitis in relation to the immunoglobulins and complement and in relation to the normalization of the transaminases and bilirubinemia . | NA | {
"id": "C0019168",
"name": "hbsag",
"pos": [
39,
44
]
} | {
"id": "C0019165",
"name": "hbag",
"pos": [
54,
58
]
} |
the value of phenobarbital in the treatment of free bilirubin icterus is demonstrated by a series of clinical experiments in which the drug was administered to patients with bilirubinaemia , even at high levels , the situation being brought back to normal within about two weeks . | NA | {
"id": "C0022346",
"name": "icterus",
"pos": [
62,
69
]
} | {
"id": "C0020433",
"name": "bilirubinaemia",
"pos": [
174,
188
]
} |
characteristic clinical findings included a dry , hacky cough , refractive to the usual antitussives , starting 1 -- 2 weeks prior to admission , fever up to 104 , malaise , headache , anorexia , shortness of breath and cyanosis . | NA | {
"id": "C0037088",
"name": "clinical findings",
"pos": [
15,
32
]
} | {
"id": "C0010520",
"name": "cyanosis",
"pos": [
220,
228
]
} |
perfusions of 0.9 % nacl , one to ten micrograms of acetylcholine , isoproterenol , epinephrine and norepinephrine , into the anterior septal artery caused variations in the ecg ranging from exaggerated st-t changes to pr prolongation , ectopic atrial , nodal and ventricular beats , a-v blocks and dissociations , atrial fibrillation and ventricular fibrillation . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
84,
95
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
100,
114
]
} |
there are two kinds of adrenergic receptors in rat fundus ( stomach ) , the alpha receptors are stimulated with adrenaline and noradrenaline and can be blocked effectively with azapetine and the beta receptors are stimulated with isoprenaline and adrenaline and can be blocked effectively with propranolol . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
127,
140
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
247,
257
]
} |