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dict | t
dict |
|---|---|---|---|
in contrast , in wish and in kb xenografts , the bm stained human as well as murine type iv collagen epitopes . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
49,
51
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
84,
100
]
} |
both platelet adenine nucleotides and the platelet-derived extracellular matrix protein ( ecm ) , thrombospondin , can prime the neutrophil for subsequent o2- generation following activation of the cells with the chemotactic peptide , f-met-leu-phe ( fmlp ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
5,
13
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
98,
112
]
} |
heterogeneity of islet cell autoantibodies in terms of insulin release from rat islets and insulinoma cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
17,
27
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
91,
98
]
} |
using primary cultures of dispersed rat fetal hypothalami , we studied the effect of forskolin and the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate , activators of protein kinase a and c , respectively , on corticotropin-releasing hormone ( crh ) regulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
46,
57
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing",
"pos": [
214,
237
]
} |
we investigated the possibility that hypothalamic somatostatin might be mediating these dichotomous observations by using passive immunization techniques . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
37,
49
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
50,
62
]
} |
these results suggest that the previously described inhibitory action of glucocorticoids on gh secretion in vivo are mediated via altered hypothalamic somatostatin tone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
138,
150
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
151,
163
]
} |
the simultaneous detection of pnmt and somatostatin antigens in hypothalamic sections of colchicine pretreated animals revealed a congruency in the distribution of the labelled elements and also close juxtaposition of pnmt-ir axons to somatostatin producing neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
64,
76
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
235,
247
]
} |
cd4+ t cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class ii-specific t-cell lines cultured and grown from previous biopsies . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
0,
3
]
} | {
"id": "C0019630",
"name": "major histocompatibility",
"pos": [
125,
149
]
} |
these data demonstrate that cardiac biopsies contain cd4+ t cells of recipient origin which show anti-idiotype-like reactivity against t-cell receptors specific for donor-specific major histocompatibility complex class ii molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
53,
56
]
} | {
"id": "C0019630",
"name": "major",
"pos": [
180,
185
]
} |
in order for a cd4+ t cell to recognize antigen , it must be presented in association with a class ii major histocompatibility complex molecule by another cell type and , in order to lead to functional t-cell activation , the antigen presenting cell must also provide costimulatory signals . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
15,
18
]
} | {
"id": "C0019630",
"name": "class ii major histocompatibility complex",
"pos": [
93,
134
]
} |
the tsh and hpr responses after trh in hypopituitary patients will determine whether the primary defect resides in the pituitary or hypothalamus , but can not delineate the hypothalamic defect as a deficiency of hypothalamic hormone production or neurohumoral transmission . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
132,
144
]
} | {
"id": "C0020656",
"name": "hypothalamic",
"pos": [
212,
224
]
} |
the ability of erythrocyte hemolysates to decarboxylate dopa is associated with interaction between dopa and methemoglobin ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
15,
26
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
109,
122
]
} |
the aim of this study was to evaluate qualitatively the occurrence of the basement membrane proteins laminin and type iv collagen in the kidneys of ten infants with congenital nephrotic syndrome of the finnish type ( cnf ) aged from 3 to 23 months and to compare the results with those for age-matched controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
74,
91
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
113,
129
]
} |
these data show that rapid provision of new monocytes to the granuloma is one of the important factors in the defense mechanism , that lymphocytes separated from lepromatous patients are not activated in response to m. leprae antigen , and that they do not secrete corresponding lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
135,
146
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
279,
290
]
} |
since many of the functions of thymosin , the alleged active principle in thymus are identical to those of adenosine deaminase , it is postulated that thymosin may be a subunit of adenosine deaminase . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus",
"pos": [
74,
80
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
151,
159
]
} |
increased expression of class i ( hla-a , b , and c ) molecules was observed in the affected islet cells , and in damaged islets showing scant lymphocytic infiltration , some beta cells ( still producing insulin ) , but not glucagon or somatostatin cells , were hla-dr positive . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
93,
104
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
204,
211
]
} |
it is concluded that the hypothalamus of 3-day-old rats is able to release enough somatostatin to inhibit gh secretion after stress . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
25,
37
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
82,
94
]
} |
responsiveness of immature versus adult male rat hypothalami to dibutyryl cyclic amp- and forskolin-induced lhrh release in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
49,
60
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
108,
112
]
} |
the results indicate that at 25 days of age , male rat hypothalami were most responsive to cyclic amp ( 162 % of preinfusion basal lhrh release ) ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
55,
66
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
131,
135
]
} |
to address the possibility that the lack of effectiveness of dbcamp in the older animal preparations was solely due to an increasing sensitivity of male rat medio-basal hypothalamus fragments to butyrate , we examined the effect of forskolin ( 10 ( -4 ) m ) , an adenylate cyclase stimulator , on lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
169,
181
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
297,
301
]
} |
despite a 50 % decrease of da contents in parkinsonian hypothalami , no variations of corticoliberin and somatocrinin contents were found : 16.6 +/- 1.78 pg/mg tissue in parkinson disease vs 16.71 +/- 1.89 in controls for human corticotropin-releasing factor ( hcrf 1-41 ) and 37.38 +/- 11 vs 45.16 for human growth-hormone-releasing factor ( hgrf 1-44 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
55,
66
]
} | {
"id": "C0010132",
"name": "corticoliberin",
"pos": [
86,
100
]
} |
despite a 50 % decrease of da contents in parkinsonian hypothalami , no variations of corticoliberin and somatocrinin contents were found : 16.6 +/- 1.78 pg/mg tissue in parkinson disease vs 16.71 +/- 1.89 in controls for human corticotropin-releasing factor ( hcrf 1-41 ) and 37.38 +/- 11 vs 45.16 for human growth-hormone-releasing factor ( hgrf 1-44 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
55,
66
]
} | {
"id": "C0037668",
"name": "human",
"pos": [
303,
308
]
} |
in the experimental animal , the estrogen effect takes place at the level of the hypothalamus in the release of lhrh and at the level of the pituitary in increasing its sensitivity to lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
81,
93
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
184,
188
]
} |
the effects of progesterone may be manifested at higher brain centers , the hypothalamus and the pituitary , and may involve not only the release of lhrh but also an alteration of the pulsatile pattern of release of lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
76,
88
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
216,
220
]
} |
that macrophages rather than contaminating granulocytes or lymphocytes , had mediated the observed damage was demonstrated by the use of a lymphokine treated macrophage cell line , ic-21 . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
59,
70
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
139,
149
]
} |
spectrophotometrically , the red cell rich clot had an absorption curve typical of hemoglobin pigment while the red cell poor clot , in the absence of hemoglobin , had poor absorption between 350 and 600 nm and was unable to absorb argon laser energies . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
29,
37
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
151,
161
]
} |
large hypothalamic lesions including the paraventricular nucleus and the median eminence did not cause a decrease in the extrahypothalamic crf concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
139,
142
]
} |
upon gel filtration the low molecular weight crf of the hypothalamus co-eluted with synthetic rat crf whereas that of the spinal cord was considerably more retarded . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
56,
68
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
98,
101
]
} |
we conclude that crf in many extrahypothalamic brain areas and the spinal cord does not originate from the hypothalamus and that there is some heterogeneity in the molecular form of the extrahypothalamic crf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
107,
119
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
204,
207
]
} |
the data support the view that islet blood flow is not necessarily related to the metabolic status of the islet cells or to the insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
106,
117
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
substantial evidence now exists to indicate that the endogenous hypothalamic opioidergic mechanism ( s ) represents one of the important controlling systems for release of gonadotropin-releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
64,
76
]
} | {
"id": "C0023610",
"name": "release",
"pos": [
161,
168
]
} |
this study examines two interactions of a variety of bacteria with the cell matrix noncollagenous proteins fibronectin and laminin and with basement membrane ( type iv ) collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
140,
157
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
160,
167
]
} |
the mean red blood cell volume , mean red blood cell hemoglobin , and mean red blood cell hemoglobin concentration rounded to the nearest 0.5 were , respectively , 89.5 fl , 30.5 pg , and 34.0 dl . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
9,
23
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
90,
100
]
} |
bacillus calmette-guerin or mdp was incubated for three days with lymphocytes from neck nodes , after which the human squamous tumor cells from the patient were exposed continuously to the resulting lymphokines in soft agar . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
66,
77
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
199,
210
]
} |
in the presence of a non-stimulatory concentration of glucose ( 3 mm ) , sparteine ( 0.2-1 mm ) decreased the rate of 86rb+ efflux from islet cells , depolarized the b-cell membrane , induced a glucose-like electrical activity and stimulated insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
136,
141
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
242,
249
]
} |
these studies suggest that normal placental tissue synthesizes a small precursor form of free hcg alpha-subunit that is converted to a larger form prior to secretion and that the free forms of alpha-subunit do not bind to purified hcg beta-subunit . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
34,
43
]
} | {
"id": "C0106132",
"name": "hcg beta-subunit",
"pos": [
231,
247
]
} |
reviewed here are some of our recent attempts at immune reconstitution in acquired immunodeficiency syndrome , using either whole scale immune reconstitution through the use of lymphocyte transfers and bone marrow transplantation or enhancement of the remaining immune systems with the t-cell-derived lymphokines interleukin-2 or immune gamma-interferon . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
177,
187
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
301,
312
]
} |
in order to evaluate central opioid tonus , plasma lh rise after naloxone injection was measured , bearing in mind the tonic inhibition of endogenous opioid on hypothalamic lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
160,
172
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
173,
178
]
} |
hgrf administration is a reliable test of gh reserve and , when used in combination with conventional tests , may help to identify gh-deficient children with hypothalamic grf deficiency . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
158,
170
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
171,
174
]
} |
the results can be explained by stimulation of srif release from the hypothalamus by gh and somatomedins , with subsequent internalization of the pituitary plasma membrane srif receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
69,
81
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
172,
176
]
} |
these results suggest that prostatic 5 alpha-reductases of rats , dogs , and humans are significantly different . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
27,
36
]
} | {
"id": "C0039602",
"name": "5",
"pos": [
37,
38
]
} |
heterogeneity existed within the dense peak , related to the degree of thyroglobulin degradation , as it was observed that thyroid lysosomes become denser with increasing proteolysis of thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
123,
130
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
186,
199
]
} |
on the basis of our observations , we hypothesize that the primate hypothalamus , through changes in gnrh secretion , actively participates in the e2b-induced lh surge . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
67,
79
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
101,
105
]
} |
to elucidate the mechanism ( s ) mediating the gh suppression response to insufficient glucose we assessed the involvement of the two hypothalamic gh-regulatory peptides , somatostatin ( srif ) and gh-releasing factor ( grf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
134,
146
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
187,
191
]
} |
hypothalamic somatostatin mediates the suppression of growth hormone secretion by centrally administered thyrotropin-releasing hormone in conscious rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
13,
25
]
} |
stimulation of cyclic adenosine 3',5'-monophosphate production enhances hypothalamic luteinizing hormone-releasing hormone release without increasing prostaglandin e2 synthesis : studies in prepubertal female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
85,
122
]
} |
to assess whether islet cells are equipped with recognition units which allow an intra-islet regulation via released hormones , the presence of insulin and glucagon receptors is investigated on purified pancreatic a and b cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
18,
29
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
144,
151
]
} |
these results show that glucocorticoids have different effects in vivo and in vitro , suggesting that inhibitory effects of glucocorticoids on secretion of lh in vivo may not be exerted directly on the pituitary but are exerted elsewhere , perhaps by altered hypothalamic secretion of gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
259,
271
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
285,
289
]
} |
we have produced a surrogate erythrocyte ( 'hemosomes ' ) by encapsulating human hemoglobin in polymerized vesicles composed of diacetylenic phospholipids plus or minus cholesterol . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
29,
40
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
81,
91
]
} |
a new erythrocyte population with increased cell diameter and volume appears during the adaptive readjustment of the erythron system with the augmentation of intracellular hemoglobin content in prolonged exposure to heat . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
6,
17
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
172,
182
]
} |
islet isolation from atrophied pancreas after short-term duct ligature -- evidence for normal in vitro release of insulin and somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
0,
5
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
114,
121
]
} |
the hypothalamus mediates the neuroendocrine control of reproduction in both males and females through pulsatile secretion of gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
126,
130
]
} |
binding of 125i-tsp to lipids from sheep and human erythrocytes and human platelets resolved on thin layer chromatograms indicates that sulfatides are the only lipids in the membrane which bind tsp . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
74,
83
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
194,
197
]
} |
a monoclonal antibody against tsp ( a2.5 ) , which inhibits hemagglutination and agglutination of fixed activated platelets by tsp , strongly inhibited tsp binding to sulfatides . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
114,
123
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
152,
155
]
} |
moreover , the induction of stress fibres in the presence of basement membrane ( type iv ) collagen may explain the failure of aortic ec to migrate and repopulate wounded regions of intima during atherogenesis in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
61,
78
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
81,
88
]
} |
we speculate that such alterations in pulsatile lh release in exercising women reflect an adaptive response of the hypothalamic pulse generator controlling the intermittent gnrh signal to the pituitary gland . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
115,
127
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
173,
177
]
} |
okt3 binds to a t cell molecule , t3 , associated with the t cell antigen receptor and involved in t cell activation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
16,
22
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
59,
82
]
} |
the in vitro t cell-dependent antibody response of human lymphocytes to influenza virus x31 was used to study the role of t cell-derived lymphokines in antigen-specific responses . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
57,
68
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
137,
148
]
} |
we conclude that infantile ovariectomy either removes , or prevents the development of , a hypothalamic inhibitory mechanism which normally modulates the responsiveness of the pituitary to stimulation with gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
91,
103
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
206,
210
]
} |
the rate of thyroid secretion was estimated by measuring the rate of hydrolysis of labelled thyroglobulin from mouse thyroid glands in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
12,
19
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
92,
105
]
} |
the results are discussed in relation to previous studies of the role of the autonomic innervation to the endocrine pancreas in the control of insulin release during hyperglycaemia in conscious calves and weaned lambs . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine",
"pos": [
106,
115
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
143,
150
]
} |
between 8 and 25 weeks of age , significant ( p less than 0.01 ) increases in basal and depolarization-induced release of lhrh ( 93 and 330 % , respectively ) were accompanied by a significant ( p less than 0.01 ) rise in the residual lhrh content of mbh tissue ( 152 % ) , observations which suggest that the ability of the hypothalamus to synthesize and secrete lhrh increases as sexual maturation proceeds . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
325,
337
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
364,
368
]
} |
because inherent regional differences in colonic epithelium may determine the biologic behavior of tumors originating from different sites , and inasmuch as colonic epithelial cells secrete mucins that may reflect the state of cell differentiation , colonic goblet cell mucin was analyzed with the use of fluorescein isothiocyanate-conjugated lectins and fluorescence microscopy in normal fetal and adult mucosa and in cancers of the proximal and distal colon . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
165,
181
]
} | {
"id": "C0026682",
"name": "mucin",
"pos": [
270,
275
]
} |
a correlative study of the binding of dexamethasone in hypothalamic blocks in vitro with its ability to inhibit the release of bioactive corticotrophin-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
55,
67
]
} | {
"id": "C0010132",
"name": "corticotrophin-releasing factor",
"pos": [
137,
168
]
} |
dexamethasone , when added to hypothalami in vitro caused a biphasic inhibition of bioactive corticotrophin-releasing factor ( crf ) release , and the extent of the second phase of inhibition was dose-related . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
30,
41
]
} | {
"id": "C0010132",
"name": "corticotrophin-releasing factor",
"pos": [
93,
124
]
} |
to study whether this is due to a direct effect on the endocrine pancreas , the effects of the thiazide hydroflumethiazide on the release of glucagon , insulin , and somatostatin from the isolated perfused pancreas of normal and alloxan diabetic dogs were examined . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine",
"pos": [
55,
64
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
152,
159
]
} |
effects of advancing age on hypothalamic neurotransmitter content and on basal and norepinephrine-stimulated lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
109,
113
]
} |
these data suggest that the age-related reduction in lh secretion by the male rat is due to a reduction in hypothalamic ne metabolism and not to an inability of the lhrh neuron to respond to ne stimulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
107,
119
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
165,
169
]
} |
these results demonstrate that opiate and opioid peptide stimulation of pituitary gh secretion is mediated through hypothalamic grf and presents an animal model in which the stimulated secretion of gh and prl can be specifically dissociated . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
115,
127
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
128,
131
]
} |
measurements were carried out of the rate constants of erythrocyte thermohemolysis and hemoglobin thermoaggregation in various animal species and also for the man under the action of hemoglobin-modifying factors ( co2 , o2 , ethanol ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
55,
66
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
183,
193
]
} |
we report here on the identification of two integrins on the surface of human platelets that bind to thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
78,
87
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
101,
115
]
} |
when platelet membrane proteins are radiolabeled with 125i-lactoperoxidase , solubilized in n-octylglucoside , ( boehringer mannheim biochemicals , indianapolis , in ) , and applied to a column of thrombospondin-sepharose , both complexes are bound to the column and specifically eluted with the peptide grgdsp . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
5,
13
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
197,
211
]
} |
the alpha v beta 3 integrin on thrombasthenic platelets also binds to thrombospondin-sepharose and can be eluted with the peptide grgdsp . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
46,
55
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
70,
84
]
} |
after isolation , blood mo in six patients expressed cd14 molecules at low density when compared to normals . | tissue_is_expression_site_of_gene_product | {
"id": "C0026473",
"name": "blood mo",
"pos": [
18,
26
]
} | {
"id": "C0108768",
"name": "cd14",
"pos": [
53,
57
]
} |
no significant differences were observed between the control and sod-loaded rbcs in o2-driven methemoglobin formation or generation of thiobarbituric acid-reactive substances . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
76,
80
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
94,
107
]
} |
in contrast , rbcs with elevated sod activity pretreated with sodium azide ( to block catalase activity ) or 1-chloro-2,4-dinitrobenzene ( to deplete reduced glutathione , gsh ) showed significantly enhanced methemoglobin generation in response to superoxide generating drugs . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
14,
18
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
208,
221
]
} |
t cell receptor ( tcr ) gamma gene rearrangements were examined in panels of human t cell clones expressing tcr alpha/beta or gamma/delta heterodimers . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
0,
6
]
} | {
"id": "C0085247",
"name": "tcr alpha/beta",
"pos": [
108,
122
]
} |
both murine cd4+ and cd8+ cells are found in the thyroid infiltrate in experimental autoimmune thyroiditis ( eat ) induced with mouse thyroglobulin ( mtg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
49,
56
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
134,
147
]
} |
immunogold studies indicate that there is reduction or loss of the subepithelial portion of the basement membrane , which apparently contains normal amounts of type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
96,
113
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
160,
176
]
} |
four of five alloreactive t cell clones from leaky scid mice also apparently lacked abnormal j-associated deletions in their rearranged tcr alleles . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
26,
32
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
136,
139
]
} |
sequence comparison with other fabps of known sequence and the observed microheterogeneity demonstrated the presence in brain of several homologous fabps closely related to heart fabp and bovine mammary-derived growth inhibitor ( mdgi ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0006104",
"name": "brain",
"pos": [
120,
125
]
} | {
"id": "C1312696",
"name": "mdgi",
"pos": [
230,
234
]
} |
t lymphocytes expressing the t-cell gamma delta receptor have been shown to express preferentially the t-cell receptor v9 gamma ( trgv9 ) gene , in association with the t-cell receptor v2 delta ( trdv2 ) gene . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
0,
13
]
} | {
"id": "C0034790",
"name": "t-cell",
"pos": [
169,
175
]
} |
cultured cells showed variable positive immunostaining for basement membrane markers like laminin , and type iv collagen , and for laminin receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
59,
76
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
104,
120
]
} |
further , the hpc secreted from the gene-amplified cell lines had full anticoagulant activity when compared to plasma-derived hpc . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
111,
117
]
} | {
"id": "C1949480",
"name": "hpc",
"pos": [
126,
129
]
} |
in the colonic epithelium , the percentage of t cells expressing gamma/delta-chains was higher , with a mean value approximating 15-20 % , although this apparently large percentage increase compared with small bowel reflects in part a much lower density of colonic iel , as absolute numbers of tcr delta 1+ cells were comparable . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
46,
53
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
294,
297
]
} |
as these lymphocytes inhibit tumor growth by recruiting host reactivity through the release of lymphokines , the peri-tumoral injection of interleukin-2 ( il-2 ) was then experimented . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
9,
20
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
95,
106
]
} |
lastly , in order to ascertain whether lymphocytes themselves could be dispensed with , lymphokines were injected around tumor-draining lymph nodes . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
39,
50
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
88,
99
]
} |
two leukocyte receptors ( cd11a/cd18 and cd11b/cd18 ) mediate transient adhesion to endothelium by binding to different ligands . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
4,
13
]
} | {
"id": "C0079785",
"name": "cd11b/cd18",
"pos": [
41,
51
]
} |
these marrow- and thymus-derived stromal cell clones also have lymphopoietic activities : precursor t cells , or pre-b cells accumulated in co-cultures of thymus cells and the stromal clones , as indicated by cell surface markers , t cell receptor and immunoglobulin gene rearrangements . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
100,
107
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
232,
247
]
} |
the lh pulse pattern was determined as an index of hypothalamic lhrh secretion in 21 infertile patients with idiopathic azoospermia or oligoasthenozoospermia and 14 fertile age-matched controls by frequent blood sampling at 10-min intervals for 24 h . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
51,
63
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
64,
68
]
} |
thus unlike anovulatory infertility in females , functional defects of hypothalamic lhrh secretion remain an uncommon finding in male infertility . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
71,
83
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
84,
88
]
} |
using rat hypothalamic explants in vitro , we have studied the release and hypothalamic content of gh-releasing hormone ( ghrh ) and somatostatin in male and female wistar rats at four different ages ( 10 , 30 and 75 days , and 14 months ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
133,
145
]
} |
second , each t cell type has a different recognition pattern of epitopes and agretopes for a particular antigen-mhc complex , thus , ruling out a static model of t cell recognition , which assigns certain , invariant agretopic residues to the peptide by which it interacts with the mhc molecule independently of the tcr . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell type",
"pos": [
14,
25
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
317,
320
]
} |
cytotoxic studies of lymphocytes from regional lymph nodes ( rn-lak ) , peripheral blood ( pb-lak ) and those stimulated by autologous tumor cells and then activated by recombinant interleukine 2 ( st-lak ) against autologous lung cancer cells , were conducted using the 51cr-releasing test . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
21,
32
]
} | {
"id": "C0024297",
"name": "lak",
"pos": [
201,
204
]
} |
although il-2r beta seems to be constitutively expressed on resting t lymphocytes , the growth of these t cells is specifically induced by antigenic triggering by the t-cell receptor ( tcr ) , which then results in the transcription of both il-2 and il-2r alpha genes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
68,
81
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
167,
182
]
} |
in experiments on isolated pancreatic islets from mice we now demonstrate that tolazoline and antazoline which are chemically closely related to phentolamine , share its ability to potentiate insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
27,
37
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
192,
199
]
} |
seven to 12 d of intrauterine hyperinsulinemia decreases serum iron and increases total red cell iron , most likely by stimulating increased hb synthesis in response to low arterial oxygen saturation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
88,
96
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
141,
143
]
} |
by using membrane-incorporated monoclonal antibodies , we artificially forced t cells to bind to antigen-presenting cells in a mixed lymphocyte reaction system and thereby bypassed the need for tcr engagement and also made it possible for any surface molecule on antigen-presenting cells to deliver a stimulatory signal to the t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
78,
85
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
194,
197
]
} |
we conclude that u-pa is released by ddavp concurrently with t-pa and that it is presumably from the same origin as t-pa i.e . endothelial cells . u-pa and t-pa may therefore cooperate in the enhanced fibrinolytic activity upon ddavp infusion . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
127,
144
]
} | {
"id": "C0042071",
"name": "u-pa",
"pos": [
147,
151
]
} |
subsequently , we purified this pci-ii by isolating apc-pci-ii complexes from plasma deficient of vitamin k dependent proteins , pci-i and beta 2-glycoprotein-i , to which purified human apc had been added . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
78,
84
]
} | {
"id": "C1949480",
"name": "human apc",
"pos": [
181,
190
]
} |