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the results suggest that this lower ifn-gamma production in ms may be secondary to the disease , and the primary defect may be a severe reduction of the essential lymphocyte populations required for an effective lymphokine cascade to produce the normal immune response against infection . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
163,
173
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
212,
222
]
} |
human t lymphocytes stimulated by mitogens ( pha , cona or pwm ) , anti-tcr/cd3 monoclonal antibodies or allogeneic leucocytes express this 26 kda antigen after 2-4 hours . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
6,
19
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
72,
75
]
} |
following acute k repletion in vivo leading to complete normalization of muscle k content , the incorporation of [ 3h ] leucine into muscle protein showed no increase within 2 h , but reached 76 and 104 % of the control level within 24 and 72 h respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
73,
79
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
133,
147
]
} |
the inhibitory effect of erythrocyte suspensions and haemoglobin solutions on the response of the bovine retractor penis muscle ( brp ) and the rat anococcygeus to field stimulation of their non-adrenergic non-cholinergic ( nanc ) nerves has been compared . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
25,
36
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
53,
64
]
} |
although it has been suggested that this stimulatory effect may be mediated via an action on hypothalamic crf-41 release , direct measurements have not previously been made . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
93,
105
]
} | {
"id": "C0010132",
"name": "crf-41",
"pos": [
106,
112
]
} |
t cells expressing either the alpha beta or gamma delta antigen receptor ( tcr ) are distinct cell lineages . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
75,
78
]
} |
2 ) the alpha 2-adrenergic blockade causes suppression of the release of hypothalamic grf and enhanced release of endogenous somatostatin , thereby suppressing gh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
73,
85
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
86,
89
]
} |
2 ) the alpha 2-adrenergic blockade causes suppression of the release of hypothalamic grf and enhanced release of endogenous somatostatin , thereby suppressing gh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
73,
85
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
125,
137
]
} |
while these gender-associated differences may represent effects of the gonadal hormones directly on the somatotrope , they could reflect modulation of the secretion of hypothalamic srif and/or ghrh by the prevailing gonadal hormone environment . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
168,
180
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
181,
185
]
} |
the leukocyte integrins lfa-1 , cr3 and p150,95 are a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
4,
13
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
32,
35
]
} |
the cd3-epsilon enhancer did not display sequence similarity with the t cell-specific enhancer of cd3-delta , a related gene co-regulated with cd3-epsilon during intrathymic differentiation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
70,
76
]
} | {
"id": "C0759310",
"name": "cd3-epsilon",
"pos": [
143,
154
]
} |
we conclude that the monoclonal antibody tg 158 detects an epitope which is present in thyroid tissue-derived tg but not in circulating thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
87,
94
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
136,
149
]
} |
these results indicated that t cell hybridomas recognized the conformational change of class i molecule resulting from the exchange of the alpha 3 domain via their t cell receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
29,
35
]
} | {
"id": "C0034790",
"name": "t cell receptors",
"pos": [
164,
180
]
} |
acrylamide gel electrophoretic analysis of adenohypophyseal sth and lth in androgenized male and female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
43,
59
]
} | {
"id": "C0033371",
"name": "lth",
"pos": [
68,
71
]
} |
[ erythrocyte carbonic anhydrases of men and some animals . 5. hemoglobin and carbonic anhydrase of primates , chimpanzees ( pan troglodytes ) and cynomolgus ( macaca irus ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
2,
13
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
63,
73
]
} |
concentrations of glucose 6-phosphate and 6-phosphogluconate were studied in islets of langerhans isolated from rat pancreas and incubated in the presence of various agents that induce insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
77,
97
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
185,
192
]
} |
[ contribution to the cytological study of the anterior lobe of the pituitary of the adult non-lactating castrated rat after parturition and treated with luteotrophic hormone ( lth ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "of",
"pos": [
40,
42
]
} | {
"id": "C0033371",
"name": "luteotrophic hormone",
"pos": [
154,
174
]
} |
mechanism of myocardial protection during blood-potassium cardioplegia : a comparison of crystalloid red cell and methemoglobin solutions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
101,
109
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
114,
127
]
} |
differential diagnosis between hypothalamic and pituitary hgh deficiency with the aid of synthetic gh-rh 1-44 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
31,
43
]
} | {
"id": "C0037668",
"name": "gh-rh 1-44",
"pos": [
99,
109
]
} |
increased hypothalamic gnrh secretion appears to influence positively the number of pituitary gnrh receptors ( gnrh-r ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
111,
115
]
} |
gnrh also increases serum lh and gnrh-r in hypothalamus-lesioned rats , and these animals injected with exogenous gnrh are , therefore , a good model in which to study the site of steroid feedback at the pituitary level . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
43,
55
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
114,
118
]
} |
for the anterior pituitary gland , the prolactin , tsh , gh , lh and fsh contents in male nar were significantly lower than those of normal rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
8,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
39,
48
]
} |
the comparison of thallium scans with plasma thyroglobulin levels showed certain differences ( high plasma thyroglobulin without any proof of remaining thyroid tissue in one patient and normal/low plasma thyroglobulin in the presence of a tumour in two patients ) but both measurements could give additional information . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
152,
159
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
204,
217
]
} |
secondly , the use of the color of hemoglobin itself to identify mixed colonies prevents the detection of those colonies where the erythrocytic component is small or contains relatively little hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
131,
143
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
193,
203
]
} |
extracts of both rat hypothalamus and pancreas were analyzed for their corticotropin releasing factor ( crf ) -like immunoreactivity by radioimmunoassay ( ria ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
21,
33
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
104,
107
]
} |
in the case of the hypothalamus , besides the rat crf , further identified by high-pressure liquid chromatography ( hplc ) , two peptide components , a 20-kda and a 10-kda species were detected . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
19,
31
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
50,
53
]
} |
isolation of t-lymphocyte lines with specificity for islet cell antigens from spontaneously diabetic ( insulin-dependent ) rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
53,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
103,
110
]
} |
thus , raised basal growth hormone levels in diabetes and the fall that follows intensive insulin treatment may reflect changes in hypothalamic regulation of , rather than in pituitary responsiveness to , grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
131,
143
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
205,
208
]
} |
we used a cloned human cdna probe homologous to the placenta chorionic gonadotropin beta subunit ( cgb ) and to the pituitary luteinizing hormone beta subunit ( lhb ) and southern blotting techniques to analyse dna from a series of rodent x human somatic cell hybrids for the presence of specific gonadotropin beta subunit related sequences . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
52,
60
]
} | {
"id": "C0106132",
"name": "chorionic",
"pos": [
61,
70
]
} |
kinetics of thymidine entry into tonsillar lymphocytes and its alteration in the presence of a lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
43,
54
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
95,
105
]
} |
these agents may interfere with critical lymphocyte - macrophage interactions ( lymphokine/monokine synthesis and/or secretion ) that are required for intact suppressor responses . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
41,
51
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
80,
90
]
} |
the method was based upon an assumption that intravenously injected anti-cea is not accessible to normal epithelial cells , since the tight junction will act as a barrier for the diffusion of antibodies from the interstitium to the apical cell surface , but the anti-cea will form immunecomplexes with the cea on the baso-lateral surface of neoplastic cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
105,
121
]
} | {
"id": "C0007082",
"name": "cea",
"pos": [
306,
309
]
} |
modulation by recombinant dna leukocyte ( alpha ) and fibroblast ( beta ) interferons of the expression and shedding of hla- and tumor-associated antigens by human melanoma cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
54,
64
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
67,
71
]
} |
the ability of this method to detect specific binding of soluble ia with antigen activated t cells makes it a useful tool for studying interaction of membrane free major histocompatibility complex ( mhc ) products with native t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
91,
98
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
226,
241
]
} |
incubation of rat fibroblasts ( rfa-1 ) with theophylline after newcastle disease virus ( ndv ) induction , increased rat fibroblast interferon ( rfifn ) yields 3 to 10-fold . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
18,
29
]
} | {
"id": "C0015980",
"name": "fibroblast interferon",
"pos": [
122,
143
]
} |
they also suggest that although a possible augmentation of the hypothalamic lhrh release at the preovulatory phase can not be denied , a series of endocrine events during the human menstrual cycle may be regulated by the feedback action of the ovarian signals on the pituitary under a fixed input of the hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
63,
75
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
317,
321
]
} |
pituitary glands of grassfrog ( rana pipiens ) , bullfrog ( rana catesbeiana ) , clawed toad ( xenopus laevis ) and two species of terrapin ( chrysemys picta and pseudemys scripta ) were incubated in medium containing hypothalamic extract ( he ) , thyrotrophin releasing hormone ( trh ) , somatostatin , dopamine , or combinations of these treatments . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
218,
230
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
289,
301
]
} |
our results demonstrate that basal and k+-induced somatostatin release from rat hypothalamic fragments are modulated by local glucose concentrations , and this effect is specific as it is not paralleled by lhrh changes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
80,
92
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
206,
210
]
} |
human hypothalamic grf shows major homologies ( 93 % , 89 % , and 86 % , respectively ) when its primary structure is compared to that of the hypothalamic grf from the porcine , bovine , caprine , and ovine species . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
155,
158
]
} |
prostatic primary lesions contained pap and psa in 13 ( 81 % ) and 12 ( 75 % ) cases , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
0,
9
]
} | {
"id": "C0138741",
"name": "psa",
"pos": [
44,
47
]
} |
oral supplementation of five patients with 50 mg pyridoxine twice daily for 2 months resulted in increased plasma and erythrocyte plp levels and a slight , but not significant , increase in erythrocyte cell number , hb , concentration , and hematocrit . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
118,
129
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
216,
218
]
} |
the ratio of the age-related enzyme , erythrocyte glutamic oxaloacetic transferase ( egot ) , to hemoglobin ( hb ) increased progressively through the fractions , suggesting a correlation between erythrocyte volume and age . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
38,
49
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
a similar relationship of egot to hb was observed to that in the human subpopulations . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "egot",
"pos": [
26,
30
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
34,
36
]
} |
isolated acini from normal mice , which have accompanying islets of langerhans , were studied under conditions where endogenous insulin was minimized . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
58,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
in view of cell distribution differences in mammalian islets of ventral and dorsal primordia , we have determined the percentage volumes of insulin- , glucagon- , and somatostatin-containing cells in primary and secondary catfish islets to ascertain if these islets correlated with those derived from ventral and dorsal primordia in mammals . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "cell",
"pos": [
11,
15
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
140,
147
]
} |
eight choriocarcinomas and two immature placentas were stained with a polyclonal rabbit anti-beta-human chorionic gonadotropin ( beta-hcg ) , a monoclonal mouse hybridoma anti-beta-hcg ( moab1 ) , and a monoclonal mouse hybridoma antibody that recognizes only a free beta-hcg chain ( moab2 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placentas",
"pos": [
40,
49
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
267,
275
]
} |
a two fold stimulation in the incorporation of [ 3h-methyl ] groups from [ 3h-methyl ] methionine into phospholipids was seen in intact pancreatic islets within six minutes of exposure to a glucose concentration that stimulates insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
136,
153
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
228,
235
]
} |
distribution dynamics of oxygen tension throughout the erythrocyte volume was calculated by means of a mathematical model describing the dynamics of oxygen transport in the erythrocyte , its shape , diffusion resistance of hemoglobin solution . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
55,
66
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
223,
233
]
} |
differences in serum concentrations , in vitro synthesis by liver slices , and cell-free translational activity of total tissue rna for alpha-fetoprotein and albumin were determined at days 40 , 60 , and 80 of gestation and in newborn pigs . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
60,
65
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
136,
153
]
} |
investigation of the effects of injecting monoamines ( noradrenaline , dopamine and serotonin ) into the third ventricle of the brain on the lh-rh content in the synaptosomal fraction of the mediobasal hypothalamus in intact and castrated male rats has demonstrated that all the three monoamines are involved in the regulation of synthesis and secretion of lh-rh and that their effects on lh-rh-producing neurons are steroid-dependent . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
202,
214
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
389,
394
]
} |
to examine the role of t-cell subsets in the development of thyroid lesions , female cba/j mice were immunized with 60 micrograms mouse thyroglobulin ( mtg ) in 0.1 ml complete freund 's adjuvant in both hind footpads . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
60,
67
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
136,
149
]
} |
in vitro , poorly iodinated thyroglobulin ( tg ) is hydrolysed at the same rate whether it is enclosed in thyroid or in liver lysosomes , while fully iodinated tg is degraded faster inside liver lysosomes . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
106,
113
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
160,
162
]
} |
after in vivo tsh administration , thyroid lysosomes hydrolyse fully iodinated tg as fast as do liver lysosomes . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
35,
42
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
79,
81
]
} |
studies performed in the homogenized thyroid tissues indicated that these goitrous glands had pronounced decrease of immunoreactive thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
37,
44
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
132,
145
]
} |
these findings suggest that antigen-specific and mitogen-induced t cell triggering are due to interaction with the same receptors of the t lymphocyte . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
65,
71
]
} | {
"id": "C0034790",
"name": "receptors",
"pos": [
120,
129
]
} |
the modification of isolated pancreatic rat islets by pretreatment with alpha-glucosidase abolished the stimulatory action of phentolamine but not changed glucose induced insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
29,
39
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
171,
178
]
} |
neuraminidase-treated rbc which contained normal amounts of hemoglobin and rbc ghosts which were hemoglobin-free were used . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
22,
25
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
whether cultured rat schwann cells synthesize the basement membrane-specific components , laminin and collagen type iv , and whether these components influence the adhesion , morphology , and growth of these cells have been investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
50,
67
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
102,
118
]
} |
more importantly , the hemoglobin effect on spectrin self-association is demonstrable at physiological hemoglobin concentration , ph , and osmolarity , suggesting that in intact red cells the spectrin dimer-dimer association , as well as the membrane skeletal structure , is strengthened by intracellular hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
178,
187
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
305,
315
]
} |
however , the possibility exists that extravascular fibronectin accumulation may be only secondary to interstitial fibrin clot formation , and that blood vessel-associated fibronectin may be only a function of adsorption onto basement membrane ( type iv ) collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
226,
234
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
246,
253
]
} |
the metabolic situation found in pancreatic islets exposed to both l-glutamine and 2-ketoisocaproate was investigated in order to assess its relevance to the synergistic effects of these nutrients upon insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
33,
50
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
202,
209
]
} |
from these results the author is of the opinion , that in the ewe , principally aha , but not mbh , retains the ability to produce lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
94,
97
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
131,
135
]
} |
the antibody inhibits the antiviral activity of human fibroblast interferon in an antiviral assay using human fs4 fibroblast , reacts immunologically with interferon-beta separated by sodium dodecylsulfate/polyacrylamide gel electrophoresis and subsequent transfer to nitrocellulose and absorbs interferon-beta immunologically when bound to cnbr-activated sepharose . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
54,
64
]
} | {
"id": "C0015980",
"name": "interferon-beta",
"pos": [
295,
310
]
} |
because the viscosity of the erythrocyte interior and the kinetics of gelation are dependent on the concentration of hemoglobin , we postulated that cetiedil might inhibit sickling by modifying erythrocyte sodium or potassium movements in a manner that would increase cell water content and thus dilute the cell hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
29,
40
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
312,
322
]
} |
at intervals , thyroid weight , dna , iodine and thyroglobulin content , thyroglobulin iodination , and intracellular droplet formation were measured . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
15,
22
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
73,
86
]
} |
it inhibits srbc rosette formation of peripheral t cells and appears to be an erythrocyte receptor of peripheral t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
49,
56
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
90,
98
]
} |
the distribution of red blood cell g6pd phenotype was studied by means of the methemoglobin elution test in newborn ( 46 ) and adult ( 50 ) gdmediterranean heterozygous females and newborn ( 20 ) and adult ( 30 ) hemizygous males . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
20,
34
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
78,
91
]
} |
treatment of human fibroblast cells with human fibroblast ( beta ) interferon for up to 8 hr resulted in the accumulation of at least four mrnas . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
19,
29
]
} | {
"id": "C0015980",
"name": "beta ) interferon",
"pos": [
60,
77
]
} |
a new hypothalamic substance , and not luteinizing hormone-releasing hormone , is detected immunocytochemically by antibody to luteinizing hormone-releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing",
"pos": [
127,
156
]
} |
adjacent paraffin sections of rat hypothalami fixed in bouin 's fluid were treated either with buffer or with luteinizing hormone-releasing hormone ( lhrh ) before immunocytochemical staining with anti-lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
34,
45
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
110,
147
]
} |
this idea was confirmed by the isolation by high-pressure liquid chromatography of a peak , distinct from lhrh , upon treatment of hypothalami with lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
131,
142
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
148,
152
]
} |
the release of heparin binding peptides from platelet thrombospondin by proteolytic action of thrombin , plasmin and trypsin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
45,
53
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
54,
68
]
} |
our results therefore suggest that , in cultured thyroid cells from human non-toxic goitre , tsh induces a resting state of the cells , characterized by reduced growth , reduced protein synthesis and reduced thyroglobulin hydrolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
49,
56
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
208,
221
]
} |
the lysosomal activity or the various experimental groups was determined by measuring the activity of beta-glycerophosphatase and cathepsin d both in thyroid homogenates and in semipurified thyroid lysosomal preparations , and the degradation of labelled thyroglobulin by the various lysosomal fractions . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
150,
157
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
255,
268
]
} |
the results suggest that thyroid lysosomal activity may participate in the autoregulation of thyroid secretion by inducing synthesis of new enzymes and modulating thyroglobulin degradation . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
25,
32
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
163,
176
]
} |
fixation of erythrocytic anions ( chlorine and 2,3 diphosphoglycerate ) modulate certain intrinsic properties , allowing the hb molecule to provide for efficacious transport of oxygen between the environment and the metabolically active tissues . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
12,
24
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
125,
127
]
} |
the investigations were directed to determining whether dehydration was accompanied by : a ) a shortened red blood cell survival , b ) altered sensitivity of the erythropoietin ( ep ) -producing mechanism , c ) a shortened red blood cell transit time , d ) changes in the ep serum half-life , e ) changes in hemoglobin p50 , and f ) reduced renal blood flow . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
105,
119
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
308,
318
]
} |
the bm components consisted of acid-extracted type iv collagen , pepsin fragments of collagen type iv , laminin , and fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "bm",
"pos": [
4,
6
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
85,
101
]
} |
the effects of gh on the release of somatostatin from the hypothalamus were assessed by measuring the concentrations of immunoreactive somatostatin ( irs ) in hypophysial portal blood of urethane-anesthetized male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
58,
70
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
135,
147
]
} |
the latter is under the synergistic influence of the pituitary gonadotropins , follicle stimulating hormone ( fsh ) , and luteinizing hormone ( lh ) , the secretion of which is , in turn , stimulated by the hypothalamic decapeptide , lh-releasing hormone ( lh-rh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
207,
219
]
} | {
"id": "C0023610",
"name": "lh-releasing hormone",
"pos": [
234,
254
]
} |
in pre-pubertal period ( 5-7 weeks of age ) , camp responses of hypothalamus and pituitary to gonadotropin or lhrh were significant , whereas responses of adrenal and ovary were slight and not significant . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
64,
76
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
110,
114
]
} |
it was found that both supernatant and particulate fractions from male rat hypothalami rapidly inactivated somatostatin and that the enzymes involved have an optimum ph of 7.3 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
75,
86
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
107,
119
]
} |
isolated pancreatic islets were used to determine whether substances of hypothalamic origin could directly influence the release of insulin and glucagon . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
9,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
132,
139
]
} |
these results suggest that stimulation of the release and synthesis of gh mediated by the hypothalamic grf fraction is under influence of the pool size of incubation media . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
90,
102
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
103,
106
]
} |
although the addition of 1 microng/ml of idm alone resulted in no effect on the basal release of these hormones , idm diminished the release of acth induced by crude rat hypothalamic extracts ( he ) or lysine-8-vasopressin ( lvp ) , and lh induced by he or luteinizing hormone-releasing hormone ( lh-rh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "he",
"pos": [
10,
12
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
257,
268
]
} |
since the latter could not be due to contaminating non-t cells , this activity was ascribed to fc receptor-bearing t lymphocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
55,
62
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
98,
106
]
} |
when the canine thyroid gland was stained by immunofluorescence and immunoperoxidase methods using undiluted thyroglobulin antiserum , a considerably stronger immunoreactivity was revealed in the parafollicular cells than in the colloid droplets and follicular cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
16,
29
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
109,
122
]
} |
the erythrocyte glycolytic intermediate 2,3-diphosphoglycerate ( dpg ) and adenosine triphosphate ( atp ) play an important role in oxygen transport and delivery by binding to hemoglobin ( hb ) and reducing its affinity for oxygen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
4,
15
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
176,
186
]
} |
nasal epithelial cells responded equally to both leukocyte and fibroblast if , with development of resistance to virus replication that was time and dose dependent . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
6,
22
]
} | {
"id": "C0015980",
"name": "fibroblast if",
"pos": [
63,
76
]
} |
to evaluate whether or not an increased ratio of t ( 3 ) to t ( 4 ) in thyroidal secretion could be contributing to this relative t ( 3 ) hyperproduction , t ( 3 ) , t ( 4 ) , and iodine were measured in thyroglobulin ( tg ) from controls and patients with graves ' disease who had been treated either with propranolol only or with antithyroid drugs plus iodide before surgery . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
71,
80
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
204,
217
]
} |
pancreatic islet tissue from lean and obese zucker rats was investigated with histologic and immunocytochemical techniques , and the changes in cytologic composition were correlated with levels of serum glucose , lipids , and insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
0,
16
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
226,
233
]
} |
red cell sod activity showed a progressive fall from 263.1 +/- 30.5 units/mg non-hemoglobin protein ( nhp ) in infants of less than 29 weeks of gestation to 168.9 +/- 21.3 units/mg nhp in infants of more than 36 weeks of gestation ( p less than 0.05 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "nhp",
"pos": [
181,
184
]
} |
at the hypothalamus , pge2 may inhibit gh-inhibiting factor ( gif ) release or induce release of gh releasing factor ( ghrf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0037659",
"name": "gh-inhibiting factor",
"pos": [
39,
59
]
} |
at the hypothalamus , pge2 may inhibit gh-inhibiting factor ( gif ) release or induce release of gh releasing factor ( ghrf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0037668",
"name": "gh releasing factor",
"pos": [
97,
116
]
} |
storage of blood in acid-citrate-dextrose ( acd ) solution gradually depletes red cell 2,3-diphosphoglycerate ( dpg ) and increases the affinity of hemoglobin for oxygen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
78,
81
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
148,
158
]
} |
in the judgment of the function of the anterior lobe of the pituitary gland with the help of the dynamics of the hgh-secretion the changes in the pretest-period should be included in order to avoid false diagnoses . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "the",
"pos": [
3,
6
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
113,
116
]
} |
temporal changes in the hypothalamic and serum luteinizing hormone-releasing hormone ( lh-rh ) levels and the circulating ovarian steroids during the rat oestrous cycle . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing",
"pos": [
47,
76
]
} |
inhibition of a-amylase activity in presence of glycogen phosphorylase , as previously observed in muscle extracts , was absent in the system of purified enzymes , but was restored by addition of proteins of the muscle extract , particularly proteins of the mitochondrial fraction which form a complex with glycogen . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
99,
105
]
} | {
"id": "C0026832",
"name": "proteins",
"pos": [
242,
250
]
} |
red cell and haemoglobin values in 44 women with a typical picutre of anorexia nervosa showed that 20.5 % presented a picture of true anaemia . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
13,
24
]
} |
the results obtained indicate that t cells do not carry or produce an excess of a1 compared to l-chain , as would have been expected if the t cell antigen receptor carried the same variable region as the ig heavy chain while being otherwise composed of nonimmunoglobulin-like structures . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
35,
42
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
140,
163
]
} |