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We are committed to our responsibility for timely reporting of safety information to the FDA and other regulatory authorities, in compliance with regulations and global expectations.

In order to ensure full transparency to our expectations, we provide annual training on adverse event reporting for employees, contractors and suppliers.

INTEGRITY & EXCELLENCE Protecting Product Counterfeiting Through Serialization Serialization is a key part of our anti-counterfeiting efforts.

In our industry, serialization means giving a unique, identifying code to each individual carton of medicine.

As part of Regeneron’s compliance program, we hold our suppliers, contract manufacturers and business collaborators to our same high in-house standards.

We regularly monitor suppliers’ financial and operational stability by assessing criteria such as financial stress, quality management, safety compliance, conflict mineral traceability, information security and compliance with applicable laws and regulations, including those related to anti-bribery and anticorruption.

We are investing resources into deepening our relationships with key suppliers, both to enhance our supplier governance and compliance programs and to seek out areas for collaboration.

We assess suppliers annually against various criteria including risk, regulatory compliance, safety, quality and criticality to the business.

INTEGRITY & EXCELLENCE Vendor Code Our Vendor Code reflects the biopharmaceutical industry’s expectations for sustainable performance and is aligned both with Regeneron’s standards and with the Pharmaceutical Industry Principles for Responsible Supply Chain Management.

The Code sets out expectations for ethical practices on issues such as business integrity and fair competition, animal welfare, clinical trials, privacy, transparency and reporting.

Small and diverse businesses are an important part of our sourcing activities, and we actively seek firms for inclusion in the competitive bidding process.

Advance Our Goals: Cultivating a leading employee experience that is rooted in our unique science-driven culture.

Still, we operate in a competitive industry where top talent, particularly people with STEM skills, is in high demand.

It is sustained by our collaborative, science-driven culture.

An internship is an important learning experience for today’s students, providing work experience and an opportunity to learn about corporate culture beyond the textbook.

So much so, we specify that respect and inclusion are core behaviors that shape our culture in our global set of values and behaviors.

Fostering a culture of inclusion — by creating a management culture that models inclusive behaviors.

We are also taking a critical look at our talent management processes, including recruitment and performance management, to assess to what degree they may be impacted by unconscious bias.

Change-management tools and support for leaders and teams Career Development Tools TalentHub Faced with enormous growth, our company needs an accessible, functional toolkit for learning and development training that offers employees the flexibility to grow with the business.

INTEGRITY & EXCELLENCE Developing Our Future Leaders Across Regeneron As Regeneron continues to evolve as an organization through rapid growth and discovery, one of our critical challenges will be finding ways to sustain the defining aspects of our unique culture.

We believe leaders at all levels will play a pivotal, catalytic role in change management, and so we offer a wide selection of leadership learning opportunities to help them meet the challenges of today and tomorrow.

Leadership Essentials This program aims to deepen leaders’ understanding of essential leadership and management skills.

ABC’s of Management This development program offers training for IOPS leaders and future leaders, covering topics such as understanding your leadership style, situational leadership and delegation, coaching for performance and courage and conflict strategies.

Topics included: delivering and receiving feedback, decision-making and managerial courage and the power of the employee voice.

We believe all employees should have an ownership stake in the company.

We assess our compensation and rewards programs annually to ensure that we are competitive in the marketplace, while at the same time focusing our efforts on fairness and internal equity.

Consistent with our unique culture and approach to compensation, our founders believe that all employees should share in the profits that come with our success.

COMPENSATION, BENEFITS AND RECOGNITION Regeneron’s compensation, benefits and recognition philosophy focuses on supporting our employees by providing programs that are consistent with our unique culture and support the diversity of our employees at all stages of family life.

Inclusive Benefits Regeneron supports our employees and their families by providing a competitive benefits package that includes health benefits and retirement savings option, as well as support for work-life balance, education and wellbeing.

SNAPSHOT / Education Support Supporting employee continuing education is an important part of our benefits compensation.

These include hazard recognition, evaluation and control elements, workplace design and engineering, regulatory compliance management, employee and management engagement, training, communications and audits.

We adhere to the standards set by local occupational health and safety regulatory bodies, such as the Occupational Safety and Health Administration (OSHA) and the Ireland Health & Safety Authority.

These dedicated EHS specialists helped increase transparency by establishing regular EHS metrics reporting within each department.

At our IOPS facilities, we saw a significant growth in hazard reporting, led by a large increase in requests for EHS interventions.

This includes the practices codified in our updated Environmental, Health and Safety Policy, which we published in 2019.

Our employee-led green teams help embed and promote sustainability practices, and we use incentives and host corporate-wide events such as Earth Week to encourage our workforce to actively contribute to our efforts in the workplace and in our communities.

Our owned, renewable energy resources support regulatory compliance and reduce the carbon footprint of our operations As greenhouse gas (GHG) emissions continue to increase and global temperatures rise, we understand the far-reaching impacts of climate change, including water scarcity, ecosystem disturbance and short- and long-term risks to human health, access to medicine and supply chain reliability.

We are also challenging ourselves to set global, sciencebased targets for Scope and to expand reporting on Scope 3 emissions through deeper engagement with our suppliers.

We use international standards from the World Resources Institute (WRI), World Business Council for Sustainable Development (WBCSD) and the Greenhouse Gas Protocol Corporate Accounting and Reporting Standard to calculate our emissions and report our results publicly each year.

Energy Management Renewable energy and operational energy efficiency are the cornerstones of our energy management strategy.

The installations improve occupant comfort and are projected to reap energy savings of between standard windows.

Our Limerick, Ireland and Rensselaer, New York sites have robust composting programs in place, and our corporate headquarters will introduce onsite composting by employees.

WATER MANAGEMENT According to the World Resource Institute’s Aqueduct tool, Regeneron’s sites are located in areas with medium-to-high water stress, where levels of competition over water resources are greater.

In December STEM initiatives: The Regeneron DNA Learning Center, a program of Cold Spring Harbor Laboratory (CSHL), and our new title sponsorship of the International Science and Engineering Fair (ISEF), the world’s largest pre-college science and engineering competition.

Amplifying our efforts, in December we were proud to expand our partnership with the Society to become the new title sponsor of the International Science and Engineering Fair (ISEF), the world’s largest pre-college science and engineering competition, with a commitment of approximately $24 million over five years.

Winners from more than high school science fairs around the world earn the right to compete at Regeneron ISEF, where some 2,000 finalists, half of whom are young female scientists, compete for nearly $5 million in awards, prizes and scholarships.

Following a competitive application and interview process, selected students are paired with Regeneron scientists to design, develop and present their science projects.

STEM Teaching Fellowships Regeneron partners with the STEM Leadership Center and its collaborators, U.S Satellite Laboratory and Teachers College, Columbia University, to offer competitive, science educators.

SUSTAINABLE COMMUNITIES Ana Humphrey, an Alexandria, Virginia, took home the top award in the 2019 Regeneron Science Talent Search, a program of the Society for Science & the Public, the nation’s oldest and most prestigious science and math competition for high school seniors.

Other top-ten projects tackled important global issues, such as management of infectious diseases, more efficient air travel and refugee migration patterns.

This is in the top-quartile of corporate volunteer participation rates, and well above the according to the Chief Executives for Corporate Purpose 2019 benchmarking study.

The program gives Regeneron participants the opportunity to practice key leadership skills, network with colleagues and work with inspiring non-profit executives.

In compensation of more than $845 million² to employees based within New York State.

The SASB index below indicates how Regeneron’s public reporting aligns with the Biotechnology and Pharmaceuticals industry standards.

Today, we continue to keep patients at the center of all we do – they are our Guiding Star – as we also embrace corporate social responsibility (CSR) in a manner that embodies our mission, while providing value for all of our stakeholders.

Information about our response to this critical issue can be found on our website.

and our commitment to being a responsible corporate citizen helps make it possible.

Launching the International Compliance Champions program to reinforce our foundation of ethics and compliance.

Our culture is rooted in integrity, inclusiveness, and our dedication to joining and supporting the communities in which we live and work.

by defective bone mineralization that can lead to deformity of bones and other skeletal abnormalities, as well as systemic complications such as profound muscle weakness, seizures, pain and respiratory failure leading to premature death in infants.

ETHICS & COMPLIANCE: OUR FOUNDATION We build trust when we make the right choices and act with integrity.

At Alexion, we take a comprehensive view of CSR, which encompasses environmental, social and governance topics that impact our business and our stakeholders.

From these efforts, we developed the Alexion CSR-STAR Platform as our structural framework, along with a series of corresponding aspirations and performance metrics.

Recognizing the importance of corporate social responsibility at Alexion, we are pleased to publish Alexion’s first CSR report.

This report references the Global Reporting Initiative (GRI) Standards from the Sustainability Accounting Standards Board (SASB).

in CSR reporting, as described in the GRI Standards, is lower than the threshold for information that must be disclosed in mandatory f inancial disclosures, such as the Form 10-K.

The topics considered in the CSR materiality assessment were developed based on matters identified by a cross section of internal and external stakeholders, as well as a review of key frameworks such as GRI and SASB and the material topics published by peer companies and CSR leaders.

More than 60 internal and 30 external stakeholders were queried in this process.

We do this through two main impact areas: the Alexion Charitable Foundation and Corporate Giving.

Alexion community partner URU, The Right to Be, Inc. debuts their "You Can't Be What You Can't See" virtual reality learning experience at URU's Changing the Face of STEM initiative in Dallas, Texas.

The guidelines for Alexion’s Corporate Giving program are similar in focus to the Local Needs Grants of the Alexion Charitable Foundation.

Alexion’s Corporate Giving mission is to positively impact our local communities — with a particular focus on people who are disadvantaged or disenfranchised — through initiatives that advance emotional well-being, provide educational opportunities and promote diversity and inclusion in society and critical institutions.

To align our employee volunteer efforts with our broader philanthropic strategy, we developed a formal Global Volunteer Policy in 2019.

In addition to our companywide Global Day of Service, individual Alexion offices organize their own local initiatives aligned with our Corporate Giving mission.

All employees and contractors are covered by this Policy.

Guided by our EHS Policy, Alexion manages EHS in alignment with widely accepted global standards like ISO 14001.

Our global EHS management system guides our actions and tracks key performance indicators to manage our risks and drive continuous improvement.

LEED provides a framework for creating healthy, highly efficient and cost-saving green buildings.

and method to accelerate the development of enterprise-wide solutions and integrate internal and external insights on the patient experience.

together internal and external stakeholders to identify and solve urgent patient challenges.

for scientific journals, which we expect will become a standard practice.

and provides an opportunity for idea sharing and internal knowledge building, while protecting individual privacy.

• Connected patient organizations to each other to create channels for best practice sharing.

plain-language summaries A FOUNDATION OF QUALITY At Alexion, we believe that quality is for everyone, in accordance with our CSR-STAR foundation of ethics and compliance (see Page 46).

Explicitly stated in our Quality Policy, this means that each Alexion employee is accountable for integrating quality into what we do every day through the decisions we make and actions we take.

five tenets of our Quality Policy: meet or exceed the requirements of our patients and our customers.

In country offices to illustrate how bringing a quality mindset into decision-making helps us anticipate and mitigate quality risks.

they have the right tools to emphasize quality in their daily work.

This improved procedure strengthened our existing reporting process and is essential to understanding customer feedback, the performance of our medicines and areas for improvement.

company helps us contribute to the patient journey, create value for all of our stakeholders and build a competitive advantage.

Engaging and empowering team members around the globe in shaping our culture.

We have dedicated “Culture Champions” from various functions and geographies that connect to share best practices for driving culture transformation across the organization.

principles, we regularly solicit employee feedback through our annual Culture Survey, focus groups, interviews and one-on-one dialogue.

Based on our Culture Survey results, we focused on enhancing our speak-up culture, creating an environment where employees are encouraged to share their ideas and concerns.

Nominating and Corporate Governance Committee of our Board of Directors instituted a policy stipulating that gender and ethnically diverse candidates must be included in its pool of candidates for any open director positions.

Senator Norris participated in a question and answer session, toured Alexion’s packaging and quality control facilities and had lunch with a group of employees.

During her fellowship, a law student at University of Pennsylvania attended various legal and interdepartmental meetings and worked alongside our Chief Legal Officer and other members of our legal team.

The Leadership Prof ile also provided the framework and structure for a new Enterprise Leadership training launched in 2019.

Protecting the health and safety of our colleagues and communities where we operate is essential in living our corporate values.

We’ve formalized this commitment in our EHS Policy, which extends to every location and every Alexion worker, including contractors.