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H2KP 1

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"inducing", "nondependent", "rats", "to", "self-administer", "drugs,", "the", "similarity", "of", "environmental", "conditions", "during", "self-administration", "to", "those", "in", "which", "the", "behavior", "was", "originally", "established", "appears", "to", "be", "of", "importance.", "Thompsan", "&", "Ostlund", "(95)", "made", "rats", "physically", "dependent", "on", "marphine", "using", "an", "oral", "administration", "procedure", "similar", "ta", "that", "described", "by", "Nichols,", "Headlee", "&", "Coppock", "(10).", "For", "30", "days", "of", "morphine", "deprivation", "half", "of", "the", "rats", "were", "moved", "to", "a", "different", "room", "and", "placed", "in", "new", "cages", "and", "half", "were", "Ieft", "in", "original", "cages.", "Half", "of", "each", "group", "remained", "in", "the", "same", "cage", "in", "which", "withdrawal", "had", "been", "experienced", "and", "half", "were", "moved", "to", "the", "other", "set", "of", "cages", "during", "the", "readdiction", "phase.", "Over", "3", "weeks", "oral", "preference", "tests", "were", "run", "to", "assess", "relative", "disposition", "to", "ingest", "merphine", "solution:", "Animals", "returned", "to", "the", "same", "environmients", "in", "which", "original", "drug", "admini", "tration", "had", "occurred", "ingested", "significantly", "larger", "amounts", "of", "marphine", "and", "animals", "placed", "in", "an", "environment", "different", "from", "that", "in", "which", "withdrawal", "had", "occurred", "ingested", "relatively", "greater", "amounts", "of", "morphine.", "In", "other", "words,", "the", "tendency", "to", "self-administer", "the", "drug", "is", "greater", "if", "the", "environ-", "ment", "the", "same", "as", "that", "in", "which", "the", "original", "drug-taking", "had", "occurred.", "Conversely,", "placing", "the", "animal", "in", "the", "situation", "where", "withdrawal", "has", "oc-", "curred", "decreases", "the", "probability", "of", "self-administration.", "These", "findings", "have", "intercsting", "parallels", "in", "Vaillant’s", "(96)", "follow-up", "study", "of", "morphine", "and", "heroin", "addicts.", "Addicts", "abstinent", "at", "the", "end", "af", "12", "years", "tended", "to", "have", "un-", "dergone", "in", "theic", "heme", "environment,", "In", "addition,", "many", "of", "those", "that", "were", "abstinent", "lived", "in", "different", "environments", "from", "that", "in", "which", "the", "original", "drug", "dependence", "had", "developed.", "Scliedules", "of", "drug", "reinforcement—The", "specific", "patterning", "of", "behavior", "and", "its", "persistence", "are", "dependent", "to", "a", "large", "degree", "on", "the", "schedule", "of", "rein-", "forcement", "[Skinner", "(97),", "Ferster", "&", "Skinner", "(98),", "Morse", "(99)].", "Thus,", "ane", "might", "expect", "that", "the", "specific", "pattern", "of", "drug-taking", "behavior", "and", "its", "persistence", "would", "depend", "on", "the", "schedule", "of", "reinforcement.", "Most", "studies", "have", "involved", "continnons", "reinforcement,", "i.c.,", "each", "response", "produced", "an", "in-", "Jection", "of", "drug.", "ITowever,", "a", "number", "of", "investigators", "have", "begun", "to", "examine", "intermittent", "schedules", "of", "drug", "reinforcement,", "though", "almost", "exclusively", "fixed-ratio", "schedules,", "Weeks", "(30),", "Weeks", "&", "Collins", "(38,", "100),", "and", "Collins", "&", "Weeks", "(66,", "101)", "have", "studied", "fixed-ratio", "schedules", "of", "morphine,", "dihydro.", "marphinone", "and", "codeine", "reinforcement,", "In", "several", "cases", "only", "one", "value", "of", "ratio", "schedule", "was", "used", "and", "dosage", "per", "infusion", "varied;", "however,", "in", "other", "SELF", "ADMINISTRATION", "OF", "DRUGS", "497", "studies,", "ratios", "were", "varied.", "Pickens", "(51),", "Pickens", "&", "Thompson", "(49,", "50),", "Pickens", "&", "Harris", "(55),", "and", "Pickens,", "Meisch", "&", "McGuire", "(53)", "have", "ex-", "plored", "fixcd-ratio", "schedules", "using", "stimulant", "drug", "reinforcement.", "These", "in-", "vestigators", "have", "varied", "ratios", "(FR", "1", "to", "80)", "over", "a", "range", "of", "dosages", "of", "co-", "caine,", "d-amphetamine", "and", "methamphetamine.", "In", "the", "case", "of", "stimulant", "drugs,", "a", "characteristic", "pattern", "of", "responding", "develops", "with", "runs", "of", "responses", "at", "very", "high", "rates", "followed", "by", "long", "periods", "without", "responding.", "Thesc", "“pauses”", "are", "related", "both", "to", "the", "value", "of", "the", "ratio", "schedule", "and", "the", "magni-", "tude", "of", "drug", "reinforcement,", "Overall", "response", "rate", "varies", "directly", "with", "the", "size", "of", "the", "ratio,", "aver", "a", "considerable", "range", "of", "ratios.", "Morphine.reinforced", "ratio", "performance", "is", "also", "characterized", "by", "runs", "of", "responses", "at", "high", "rates,", "but", "the", "interinfusion", "interval", "tends", "to", "be", "more", "variable", "[Collins", "&", "Weeks", "(40)].", "The", "only", "other", "simple", "intermittent", "schedule", "of", "drug", "reinfarcement", "re-", "ported", "is", "a", "variable-interval", "schedule.", "Woods", "&", "Schuster", "(41)", "have", "ex-", "plored", "morphine", "self-administration", "by", "markeys", "over", "a", "range", "of", "doses", "and", "found", "that", "a", "very", "characteristic", "constant", "low", "rate", "is", "generated.", "The", "mon-", "keys'", "response-rates", "for", "morphine", "were", "consistently", "lower", "than", "their", "re-", "sponse-tates", "fur", "food", "reinforcement.", "Two", "studies", "have", "been", "reported", "involving", "move", "complex", "schedules.", "Thompson", "&", "Schuster", "(39)", "used", "a", "fixed-interval-fixed-ratio", "chained", "sched-", "wle", "of", "intravenous", "morphine", "reinforcement", "with", "monkeys.", "The", "behavior", "de-", "veloped", "some", "characteristics", "of", "chained", "schedules", "commaonly", "observed", "using", "other", "reinforcers.", "Recent", "investigations", "of", "highly", "complex", "multioperant", "sc-", "quences", "in", "which", "morphine", "is", "the", "terminal", "reinforeer", "have", "been", "described", "Ly", "Thompson", "&", "Pickens", "(35).", "In", "this", "case", "monkeys", "performed", "a", "chain", "of", "heterogeneous", "responses", "beginning", "with", "standing", "on", "a", "platform", "scale,", "fol-", "lowed", "hy", "opening", "and", "clasing", "a", "door", "to", "a", "compartment", "in", "which", "morphine", "is", "infused,", "cooperating", "with", "anather", "monkey", "in", "holding", "a", "switch", "closed,", "and", "finally,", "operating", "2", "lever", "on", "a", "fixed-ratio", "schedule", "for", "intravenous", "mor-", "yhine.", "This", "schedule", "is", "well", "maintained,", "with", "pausing", "during", "the", "early", "com-", "potents", "varying", 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[ "202", "63", "G", "o", "o", "w", "PEILIP", "MORRIS", "CO", "CRS-35", "which", "there", "has", "been", "evidence", "of", "an", "association", "with", "an", "increased", "risk", "of", "lung", "cancer,", "diets", "low", "in", "beta", "carotene,", "and", "high", "in", "cholesterol", "and", "total", "fat.", "Results", "showed", "an", "inverse", "correlation", "between", "ETS", "exposure", "levels", "and", "consumption", "of", "beta", "carotene,", "cholesterol", "and", "total", "fat", "among", "non-stackers.", "Exposure", "levels", "were", "measured", "by", "cotinine", "levels", "and,", "therefore,", "only", "measured", "current", "exposure.", "On", "the", "basis", "of", "risk", "values", "relating", "a", "low", "beta", "carctene", "diet", "to", "the", "risk", "of", "lung", "cancer,", "the", "researchers", "ealeulated", "corrections", "to", "the", "ETS", "risic", "values", "in", "order", "to", "determine", "the", "adjustment", "that", "raay", "be", "needed", "because", "of", "reduced", "beta", "carotene", "consumption.", "He", "found", "corrections", "to", "the", "measured", "ETS", "risk", "values", "of", "about", "11.5", "ta", "12", "percent.", "For", "cholesterol", "and", "total", "fat,", "however,", "since", "consumption", "decreased", "with", "increasing", "ETS", "exposure,", "any", "confounding", "correction", "would", "tend", "to", "raise", "the", "measured", "ETS", "risk", "value.", "No", "numerical", "corrections", "were", "presented", "in", "the", "paper.", "Another", "study", "examined", "the", "possible", "contribution", "of", "a", "large", "number", "of", "food", "types", "as", "well", "as", "ETS", "to", "lung", "cancer", "risk", "among", "non-smoking", "women.®", "The", "study", "measured", "the", "relative", "risk", "of", "developing", "lung", "cancer", "as", "a", "function", "of", "the", "food", "dosage", "consumed.", "The", "only", "dietary", "components", "to", "have", "statistically", "significant", "relative", "risk", "factor", "were", "saturated", "fat,", "citrus", "fruits", "and", "juice,", "and", "beans", "and", "peas.", "The", "last", "food", "reduced", "the", "risk", "as", "its", "consumption", "increased.", "No", "effect", "due", "to", "beta", "carotene", "was", "observed.", "Furthermore,", "the", "authors", "reported", "that", "no", "interaction", "between", "ETS", "and", "the", "various", "dietary", "components", "could", "be", "mesasured.", "The", "most", "important", "contributor", "to", "increased", "lung", "cancer", "relative", "risk", "was", "saturated", "fat,", "Women", "who", "consumed", "the", "highest", "amounts", "of", "saturated", "fat", "~", "2", "mean", "value", "of", "20", "percent", "of", "their", "daily", "calories", "—", "had", "a", "lung", "cancer", "risk", "value", "of", "over", "6.", "The", "paper", "reperted", "that", "a", "biological", "link", "between", "saturated", "fat", "consumption", "and", "lung", "cancer", "was", "still", "speculative", "although", "preliminary", "experimental", "evidence", "of", "such", "a", "connection", "existed.", "The", "authors,", "however,", "were", "not", "able", "to", "offer", "any", "explanation", "for", "the", "connection", "between", "citrug", "fruit", "consumption", "and", "lung", "cancer", "risk.", "Analysis", "of", "other", "potential", "confounders", "is", "not", "as", "extensive", "as", "for", "dietsry", "factors", "but", "some", "work", "has", "been", "completed.", "One", "study", "explored", "the", "relationship", "between", "pre-existing", "lung", "disease", "(asthme,", "pneumonia,", "emphysems,", "bronchitis", "and", "tuberculosis)", "and", "lung", "cancer", "risk5!", "The", "authors", "messured", "a", "risk", "value", "of", "about", "1.4", "for", "never", "smoking", "women.", "From", "these", "results,", "the", "authors", "concluded", "that", "about", "13", "percent", "of", "all", "lung", "cancer", "deaths", "in", "never", "smoking", "women", "were", "due", "to", "a", "pre-existing", "lung", "disease.", "The", "research", "did", "not", "find", "any", "interaction", "between", "ETS", "exposure", "and", "pre-existing", "lung", "disease.", "&", "Alavanja,", "M.CR,", "eral,", "Journs!", "of", "the", "National", "Cancar", "Institute", "Vol", "85,Ne.23,", "Dac.1,", "1983,.1906-1916,", "%", "Alavanja,", "MCR,", "et.al,", "American", "Journal", "of", "Epidemiology,", "Vol", "126.", "No.8,", "Segt.", "15,", "1892,", "p.523-632.", "DRAFT", "SUBJECT", "T0", "REVISION.", "NOT", "FOR", "QUOTATION", "OR", "ATTRIBUTION.", "Ba3d-", "o", "o", "o", "6094089708" ]

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[ "Stience", "Research", "Conference", "State", "of", "The", "Business", "2000", "Center", "of", "China", "Tobacco", "Breeding", "Research", "Yuxi", "Yunman", "653100,", "Ge", "Song,", "Institute", "of", "Botany,", "Chincsc", "Academy", "of", "Sciences,", "Beijing", "100093,", "He", "Xingjin,", "Xu", "Jiemei,", "Life", "Science", "College,", "Sichuan", "University,", "Chengdu", "610064", "By", "using", "156", "random", "primers,", "RAPD)", "polymorphisms", "were", "detected", "in", "the", "31", "germplasm", "of", "flue-cared", "tobacco", "from", "native", "and", "abroad.The", "polymorphism", "information", "could", "be", "provided", "with", "30", "random", "primers.", "A", "total", "246", "loci", "were", "amplified;", "127", "loci", "of", "these", "were", "polymorphic", "(52%).", "The", "results", "showed", "that", "there", "were", "obvious", "differences", "between", "different", "cultivars.", "Most", "of", "the", "tested", "cultivars", "were", "consistent", "with", "their", "pedigrees,", "i.c.,", "most", "of", "the", "flue-cured", "tobacco", "cultivars", "were", "developed", "from", "Orinoco", "cultivar", "introduced", "from", "USA,", "The", "genetic", "basis", "of", "popularized", "flue-cuted", "tobacco", "cultivars", "in", "China", "is", "rather", "narrow", "and", "it", "is", "essential", "to", "find", "some", "new", "germplasms", "for", "the", "development", "of", "new", "cultivars,", "It", "is", "feasible,", "therefore,", "to", "identify", "flue-cured", "tobacco", "cultivars", "and", "purity", "with", "the", "RAPD", "technique.", "study", "is", "also", "valuable", "in", "the", "choice", "of", "parents", "for", "the", "development", "of", "flue-cured", "tobacco", "cultivars", "and", "hybrids.", "330", "M", "MONDAY", "25,", "FORMATION", "OF", "R-", "AND", "S-NORNICOTINE", "IN", "NICOTIANA", "TABACUM", "PROGENITORS,", "Jia", "Wang,", "Franklin", "E.", "Fannin,", "Harold", "R.", "Burton", "and", "Lowell", "P.", "Bush,", "Dept.", "of", "Agronomy,", "University", "of", "Kentucky,", "Lexington,", "KY", "40546", "USA.", "Results", "from", "our", "previous", "study", "showed", "that", "accumulation", "of", "R-nornicotine", "present", "in", "N.", "tabacum", "occurred", "mainly", "in", "the", "roots", "and", "that", "racemization", "of", "nornicotine", "was", "not", "linked", "to", "the", "demcthylation", "process.", "N.", "tomentosiformis", "and", "N.", "sylvestris", "are", "the", "likely", "parental", "species", "of", "N.", "tabacum.", "In", "N.", "tomentosiformis,", "nornicotine", "is", "formed", "throughout", "the", "growing", "season,", "whereas", "in", "N.", "sylvestris", "nornicotine", "is", "formed", "mainly", "during", "senescence", "and", "curing.", "If", "significant", "racemization", "accurs", "after", "demethylation,", "N.", "fomentosiformis", "should", "have", "higher", "levels", "of", "R-nornicotine", "than", "N.", "sylvestris", "in", "mature", "and", "cured", "leaves.", "The", "objective", "of", "this", "study", "was", "to", "measure", "the", "amount", "of", "R-", "and", "S-nornicotine", "in", "N.", "tomentosiformis", "and", "N.", "sylvestris.", "A", "sensitive,", "reproducible", "and", "simple", "GC", "method", "using", "a", "DB-1", "column", "was", "developed", "to", "analyze", "the", "enantiomers", "of", "nornicotine", "as", "their", "(-)-camphanic", "acid", "amide", "derivatives.", "The", "results", "indicated", "that", "R-nornicotine", "is", "the", "predominant", "enantiomer", "in", "the", "roots", "and", "young", "leaves", "of", "N.", "sylvestris,", "S-nornicotine", "becomes", "the", "predominant", "enantiomer", "afler", "S-nicotine", "is", "in", "the", "leaves.", "$-nornicotine", "is", "always", "the", "predominant", "enantiomer", "in", "the", "leaves", "and", "roots", "of", "N.", "tomentosiformis.", "Racemization", "of", "nornicotine", "is", "not", "linked", "to", "deraethylation", "and", "racemization", "does", "not", "scem", "to", "be", "sufficient", "to", "explain", "the", "R", "to", "§", "ratios", "of", "nornicotine", "in", "N,", "sylvestris", "and", "N.", "tomentosiformis.", "Therefore", "the", "accumulation", "of", "R-nornicotine", "may", "occur", "by", "direct", "biosynthesis", "of", "R-nornicotine", "and/or", "preferential", "demethylation", "of", "R-nicotine.", "52486", "0080", "3" ]

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"smokers", "in", "the", "Czech", "Republic,", "which", "is", "about", "20", "percent", "of", "the", "country’s", "population", "(CTK", "8/17,", "Central", "Europe", "Online", "8/17).", "Estonia:", "Reform", "In", "Excise", "Duties", "Urged", "Calling", "for", "a", "radical", "reform", "in", "excise", "duties", "on", "cigareties,", "CEO", "of", "Austria", "Tabak", "in", "Estonia", "Jaak", "Uus", "said", "the", "black", "market", "sales", "in", "cigarettes", "could", "deprive", "the", "State", "150", "million", "kroons", "(US$", "8.67", "mn)", "in", "taxes", "in", "2000.", "He", "said,", "“This", "is", "the", "money", "the", "State", "will", "fail", "to", "collect", "primarily", "because", "of", "an", "inappropriate", "excise", "policy.”", "According", "to", "the", "Finance", "Ministry", "records", "from", "January", "to", "July", "2000,", "the", "State", "reccived", "only", "235", "million", "kroons", "(US$", "13.6", "mn)", "in", "taxes", "from", "cigarelle", "companies,", "or", "just", 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"product", "sales", "to", "those", "under", "18", "years", "old", "to", "be", "in", "step", "with", "developed", "countries.", "Representatives", "of", "the", "association", "said", "tobacco", "regulations", "have", "already", "cut", "down", "25", "pereent", "of", "finished", "tobacco", "product", "sales", "in", "the", "country", "as", "of", "August", "2000.", "However,", "the", "association", "has", "not", "discussed", "the", "idea", "of", "“relurning", "tobacco", "product", "advertisement", "1o", "TV.”", "Representatives", "added", "that", "they", "are", "holding", "talks", "with", "Duma", "deputies", "on", "tobacco", "excise", "duties", "that", "are", "expected", "to", "increase", "from", "10", "pereent", "o", "30", "percent", "in", "four", "to", "five", "years", "(Russian", "Business", "Monitor", "8/18).", "Romania:", "Cigarette", "Kiosks", "Dismantled", "Bucharest’s", "new", "mayor", "Traian", "Basescu", "launched", "a", "municipal", "“face-lift”", "campaign", "on", "August", "22™", "to", "dismantle", "kiosks", "that", "were", "reportedly", "selling", "untaxed", "cigarettes,", "alcohol,", "and", "other", "products.", "Mr.", "Basescu", "had", "bulldozers", "remove", "the", "kiosks", "that", "were", "built", "illegally", "on", "public", "property", "since", "the", "1989", "fall", "of", "Communism.", "Angry", "vendors", "were", "shown", "on", "television", "hurling", "bottics", "at", "riot", "police", "as", "bulldozers", "and", "cranes", "100k", "aparl", "the", "kiosks", "in", "the", "city", "and", "surrounding", "residential", "areas", "(Reuters", "8/22).", "ASIA", "AND", "OCEANIA", "India:", "Andhra", "Pradesh’s", "Crop", "Holiday", "Discussed", "The", "Central", "Government", "has", "asked", "the", "Tobacco", "Board", "to", "permit", "leaf", "traders", "and", "dealers", "to", "buy", "tobacco", "from", "registered", "as", "well", "as", "unregistered", "farmers", "in", "the", "neighboring", "States", "of", "Andhra", "Pradesh,", "Maharashtra", "and", "Orissa", "until", "September", "30\",", "Both", "registered", "and", "unregistered", "farmers", "will", "be", "levied", "a", "service", "charge", "of", "five", "percent", "if", "they", "want", "to", "sell", "more", "than", "their", "permitted", "quota,", "Under", "the", "new", "directive,", "the", "salc", "of", "unauthorized", "flue-cured", "Virginia", "tobacco", "leaf", "would", "impose", "a", "Rs", "2", "(US$", "0.04)", "per", "kg", "charge.", "Meanwhile,", "Indian", "Tobacco", "Association", "(ITA)", "president", "B.", "Krishna", "Murthy", "on", "August", "22™", "demanded", "a", "review", "of", "the", "crop", "holiday", "in", "Andhra", "Pradesh,", "believing", "that", "the", "crop", "holiday", "could", "result", "in", "export", "losses", "in", "the", "long", "term.", "Denying", "the", "charge", "against", "the", "trade", "for", "plunging", "the", "market", "into", "a", "crisis,", "Mr.", "Murthy", "said", "the", "huge", "excess", "crop", "had", "destabilized", "the", "entire", "auction", "system,", "with", "no", "export", "orders.", "Countering", "fears", "of", "depressed", "prices,", "he", "said", "88", "million", "kg", "of", "tobacco", "has", "been", "sold", "in", "Andhra", "Pradesh,", "with", "the", "remaining", "52", "million", "kg", "likely", "to", "find", "buyers", "at", "prevailing", "or", "even", "better", "prices.", "In", "the", "neighboring", "State", "of", "Orissa,", "farmers", "have", "been", "permiuted", "to", "grow", "500,000", "kg", "of", "tobacco", "for", "the", "next", "season", "(Economic", "Times", "8/18,", "Hindu", "Business", "Linc", "8/22,", "8/23).", "ceLS", "880€sg", "WAOQ0-34", "RJR0000001145023422", "70080", "0030765", "L", "P,0.", "Box", "8019;", "Princeton,", "N.J.", "08543;", "609-275-4900;", "609-275-8379", "(fax);", "[email protected]", "3" ]

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[ "10", "T", "-t", "52799", "5645", "120" ]

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[ "SECOND", "INTERNATIONAL", "SYMPOSIUM", "ON", "HORMONAL", "CARCINOGENESIS", "STOCKHOLM,", "SWEDEN", "MONDAY,", "JULY", "4,", "1994", "Reception", "7:30", "10:00", "Novum", "Feyer", "TUESDAY,", "JULY", "5,", "1994", "Opening", "Proceedings", "8:45", "9:00", "Introductory", "Remarks", "J.J.", "Li", "(USA)", "‘", "9:00", "9:15", "Welcome", "1", "9:15", "9:25", "Speaker", "Introduction", "L.1.", "Sekely", "(USA)", "0:25", "10:05", "Sympeosium", "Address:", "J-4&.", "Gustafsson", "Novel", "Aspects.on", "Ligand", "Activated", "(SWEDEN)", "Transcription", "Factors", "in", "Control", "of", ":", "Cytochrome", "P-450.", "10:05", "10:20", "Discussion", "10:20", "10:35", "Break", "Morning", "Session:", "Epidemiology:", "Hormonal", "Cancers", "10:35", "10:50", "Chairman:", "J.R.", "Daling", "Causality", "in", "Hormone", "(USA)", "Associated", "Human", "Cancers.", ":", "10:50", "11:15", "Speaker", "1:", "L.", "Brinton", "Oral", "Contraceptives", "&", "(USA)", "Breast", "Cancer:", "A", "Collaborative", "Reanalysis.", "11:15-11:30", "Discussion" ]

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[ "3.", "Leaf", "Department", "to", "select", "the", "best", "products.", "Blends", "of", "these", "materials", "were", "incorporated", "into", "cigarettes", "at", "the", "24%", "level.", "No", "significant", "weight", "reductions", "were:", "observed", "with", "these", "materials.", "Low-density", "blends", "incorporating", "DIET-expanded", "blended", "leaf", "have", "been", "designed", "by", "the", "Leaf", "Department.", "They", "are", "designing", "different", "blends", "for", "each", "of", "the", "twelve", "brands", "under", "consideration.", "Three", "brands", "have", "been", "and", "are", "currently", "being", "tested", "for", "physicall", "and", "subjective", "properties.", "Cigarettes", "with", "wrappers", "having", "basis", "weights", "of", "23,", "35,", "and", "45", "g/m’", "were", "designed", "to", "a", "mass", "burn", "rate", "of", "40", "mg/min.", "Cigarettes", "containing", "lamina", "cut", "to", "a", "variety", "of", "widths", "were", "designed", "to", "a", "MBR", "of", "40", "mg/min.", "Additionally,", "cigarettes", "with", "circumferences", "of", "17,", "19,", "21,", "23", ",25", ",", "and", "27", "mm", "were", "designed", "to", "give", "a", "constant", "mass-burn-rate", "to", "cizcumference", "ratio.", "All", "of", "these", "samples", "were", "fabricated", "with", "common", "materials", "except", "their", "wrappers.", "The", "cigarettes", "have", "been", "tested", "for", "delivery,", "puff", "count,", "and", "MBR.", "They", "are", "currently", "being", "tested", "for", "ignition", "propensity.", "A", "study", "was", "completed", "in", "which", "the", "effects", "of", "cigarette-wrapper", "properties", "on", "the", "weight", "of", "tobacco:", "consumed", "during", "and", "between", "puffs", "were", "investigated.", "One", "hundred", "thirty", "cigarette", "designs", "were", "examined.", "All", "of", "these", "samples", "incorporate.", "common", "materials", "except", "the", "wrappers.", "The", "wrappers", "had", "various", "basis", "weights,", "permeabilities,", "chalk", "types", "and", "levels,", "and", "burn-additive", "types:", "and", "levels.", "Mathematical", "models", "were", "developed", "which", "allow", "us", "to", "accurately", "prediet", "the", "effects", "of", "all", "these", "wrapper", "properties", "on", "puff", "counts.", "6109220202" ]

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