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H2KP

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cdip-annotations-formnet-v1

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H2KP 1

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"THERAP", "CAT:", "Topical", "vasodilator.", "9243,", "Thyme.", "Dried", "leaves", "and", "flowering", "tops", "of", "Thy-", "mus", "vuigaris", "L.,", "Labiatae.", "Habit.", "Southern", "Europe;", "culti-", "vated", "in", "gardens.", "Constit.", "Volatile", "oil;", "tannin,", "gum,", "THERAP", "CAT:", "Carminative", "9244.", "Thymidine.", "1-(2-Deoxy-g-p-ribofuranosyl)-5-", "methyluracil;", "thymine-2-desoxyriboside.", "CyoH,N,Oy:", "mol", "Wt", "242.23.", "C", "45,58%,", "H", "5.83%.", "N", "11.57%,", "O", "33.03%.\"", "Con-", "stituent", "of", "deoxyribonucleic", "acid,", "¢.v.", "Isoln", "from", "thymonu.", "cleic", "acid:", "Levene,", "London,", "J.", "Biol.", "Chem,", "83,", "793", "(1929),", "Structure:", "Levene,", "Tipson,", "ibid.", "109,", "623", "(1935).", "Confor-", "mation:", "Lemicux,", "Can.", "J.", "Chem.", "39,", "116", "(1961);", "Tollin", "ef", "al..", "Nature", "217,", "1148", "(1968).", "Prepn", "of", "thymidine-3'-phos.", "phate", "and", "of", "(hymidine-S'-phosphatc:", "Tener,", "J.", "Am.", "Chermn,", "Soc", "83,", "165", "(1961).", "Review:", "Basic", "Principles", "in", "Nucleic", "Acid", "Chemistry.", "vol.", "1,", "P.", "O.", "P.", "Ts'o,", "Ed.", "(Academic", "Press,", "New", "York,", "1974)", "passim.", "See", "also", "Nucleic", "Acids.", "Rosettes", "of", "needles", "from", "cthyl", "acetate,", "mp", "185\",", "Yields", "a", "sublimate", "of", "thymine", "when", "heated.", "[alff", "-+30.6", "(o", "=", "1.029).", "uv", "max", "(pH", "7.2):", "206.5,", "267", "nm", "(€", "X", "10-3", "9.8,", "9.7),", "Voet", "et", "al,", "Biopolymers", "1,", "193", "(1963).", "Sol", "in", "water,", "metha.", "nol,", "hot", "alcohol,", "'hot", "ucctone,", "hot", "ethyl", "acetate,", "pyridine,", "glacial", "acetic", "acid;", "sparingly", "50l", "in", "hot", "chlaroform.", "Monatrityl", "thymidine,", "CpyHygN,0y,", "prepd", "by", "the", "action", "of", "triphenylmethy]", "chloride", "on", "thymidine", "in", "pyridine.", "mp", "125~", "[alf", "+11.4°(c", "=", "1.01", "in", "acetonc).", "9245,", "Thymine,", "S-Methy!-2,4(1H,3H)-pyrimidinedione;", "S-methyluracil;", "2,4-dihydroxy-5-methylpyrimidine.", "CyH,-", "N,Oy", "mol", "wt", "126.11.", "C", "47.62%,", "H", "4.80%,", "N", "22.22%.", "O", "25.37%.", "A", "pyrnimidine", "derivative;", "constituent", "of", "nucleic", "acids.", "Originally", "isolated", "from", "thymus", "nucleic", "acid:", "Levene,", "Z.", "Physiol_", "Chem.", "39,", "4", "(1903).", "Prepn", "by", "heating", "2-ethyl-", "mercapto-4-hydroxy-S-methylpyrimidine:", "Whecler,", "Mer-", "nam,", "Am.", "Chem.", "J.", "29,", "478", "(1903);", "43,", "29", "(1910).", "From", "methylcyanacetylurea", "by", "catalytic", "reduction:", "Bergmann,", "Johnson,", "J.", "Am.", "Chem.", "Soc,", "55,", "1733", "(1933).", "From", "B-meth-", "Yimalic", "acid:", "Scherp,", "J.", "Am.", "Chem.", "Soc.", "68,", "912", "(1946).", "Crystal", "structure", "of", "monohydrate:", "Gerdil,", "Acta", "Cryst.", "14,", "333", "(1961).", "Review:", "Ts'o,", "“Bases.", "Nucleosides", "and", "Nucleo-", "in", "Basic", "Principles", "in", "Nucleic", "Acid", "Chemistry", "wol.", "1,", "P.", "O.", "P.", "Ts'o,", "Ed.", "(Academic", "Press,", "New", "York,", "1974)", "pp", "also", "Acids.", "Dendritic", "or", "star-shaped", "plates", "from", "waler,", "sometimes", "short", "needles.", "Sublimes", "in", "platelets.", "Dec", "335-337°", "{Kofler", "stage).", "Weak", "acid,", "pK", "at", "25", "=.9.94.", "uv", "max", "(pH", "7.0%:", "205,", "264.5", "nm", "(¢", "X", "10-79.5,", "7.9).", "Sol", "in", "hot", "water;", "slightly", "sol", "in", "cold", "water", "(4", "g/l", "at", "257,", "Somewhat", "sol", "in", "alc;", "spar-", "ingly", "sol", "in", "ether;", "readily", "sol", "in", "alkalies", "with", "formation", "of", "salts.", "Oxidation", "yields", "urea,", "ethanal,", "pyruvic", "acid,", "formic", "—", "mMgRCK", "9250", "acid.", "Hydrazine", "reacts", "with", "thymine", "forming", "urea", "and", "4-methylpyrazolone.", "Thymine", "forms", "a", "silver", "saft", "which", "is", "sol", "in", "excess", "ammonia.", "lts", "mercuric", "and", "lead", "salts", "are", "insol.", "Thymine-2-desoxyriboside,", "see", "Thymidine.", "USE:", "In", "biochemical", "research.", "9246.", "Thymol.", "S-Mettiyt-", "(1-methylethyl)phenol", "methyl-2-isopropyl-l-phenol;", "1-methyl-3-hydroxy-", "propylbenzene;", "3-p-cymenol;", "3-hydroxy-p-cymene;", "thyme", "camphar;", "m-thymol.", "C,gH,O;", "mol", "wt", "150.21.", "C", "79.95%,", "H", "9.39%,", "0", "10.65%.", "Isolated", "by", "Neumann", "in", "1719,", "Obtained", "from", "the", "essential", "oil", "of", "Thymus", "vuigaris", "L.", "and", "Monarda", "punctata", "L.,", "Labiatae:", "Arppe,", "Ann.", "58,", "41", "(1846);", "Meyer,", "Pharm.", "Zig.", "81,", "192,", "205", "(1936).", "Also", "occurs", "in", "other", "vola-", "tile", "oils.", "Produced", "synthetically", "from", "p-cymene,", "piperitone,", "of", "m-cresol:", "Austerweil,", "Brit.", "pat.", "221,227", "(1923);", "Jeanen,", "Verdroncken,", "Compt.", "Rend.", "245,", "183", "(1957);", "Bottoms,", "U.S.", "pat.", "2,840,616", "(1958", "to", "Natl.", "Cylinder", "Gas).", "bl", "Crystals,", "mp", "515\",", "bp", "about", "233", "Appreciably", "volatile", "at", "1007", "volatilizes", "in", "water", "vapors.", "Characteristic", "odor;", "pun-", "gent,", "somewhat", "caustic", "taste.", "d", "0.9699.", "ff", "15227", "np", "1.5204.", "One", "gram", "dissolves", "in", "about", "1000", "ml", "water,", "1", "ml", "alcohol,", "0.7", "mi", "chloroform,", "1.5", "ml", "ether,", "1.7", "ml", "olive", "oil", "at", "25\"", "Sol", "in", "glacial", "acetic", "acid,", "oils,", "fixed", "alkali", "hydroxides.", "LDy,", "orally", "in", "rats:", "980", "mg/kg,", "P.", "M.", "Jenner", "e", "al.,", "Food", "Cosmer.", "Toxicol.", "2,", "327", "(1964).", "Incompar:", "Acetanilide,", "antipyrine,", "camphor,", "monobro-", "mated", "camphor,", "chioral", "hydraté,", "menthol,", "quininc", "sufate,", "salol,", "urethane,", "spirit", "nitrous", "ether;", "in", "tritarations", "because", "of", "liquefaction.", "USE:", "For", "destroying", "mold", "and", "herbarium", "parasites,", "pre-", "serving", "anatomical", "specimens.", "urine;", "for", "cmbalming.", "Has", "been", "recommended", "for", "the", "prevention", "of", "mildew", "growth", "and", "as", "an", "antimold", "for", "paper:", "Richards.", "Hawley,", "J.", "Chem.", "£d,", "16,", "6", "{1939).", "THERAP", "CAT:", "Pharmaceutic", "necessity", "for", "trichloroethylene;", "antifungal", "(topical).", "THERAF", "CAT", "(VET)::", "Has", "been", "used", "as", "anthelmintic,", "and", "as", "an", "antiseptic,", "external", "and", "internal.", "9247,", "Thymol", "Acetate,", "Acetylthymol;", "thymyl", "acetate.", "CyHy", "Oy", "mol", "wi", "19225,", "C", "74.87%", "H", "8.39%", "O", "16.64%.", "(CHY,CHC", "H,(CH,)O0CCT,.", "Prepn:", "Torea", "Str", "s", "Chem.", "Soc.", "1960,", "2312,", "Yellowish,", "cily", "lig;", "thymal", "odor.", "db", "1.009.", "bp", "243.5.", "2455", "Practically", "insol", "in", "water;", "miscible", "with", "aloohol.", "benzene,", "chloroform,", "ether.", "USE:", "Amtiseptic.", "Caution:", "Mild", "irritant.", "9248,", "Thymol", "Blve,", "4.4'-(3H-2,1-Benzoxathiol-3-ylid-", "ene)bis[S-methyl-2-(I-methylethyl)phenol]", "S,5-dioxide:", "a-hydroxy-a,a-bis(S-hydroxycarvacryl)so-tolueneswlfonic", "acid", "y-suitone;", "thymolsulfonephthalcin.", "C,Hy,O,8;", "mol", "wt", "466.58.", "C", "69.50%,", "H", "6.48%,", "O", "17.15%,", "S", "6.87%.", "Brownish-green,", "cryst", "powder;", "characteristic", "odor.", "Insol", "in", "water;", "sof", "in", "alcohol,", "dil", "alkali", "solns,", "USE:", "As", "as", "acid-base", "indicator;", "pH:", "red", "1.2", "to", "yellow", "2.:", "also", "yellow", "B.0", "to", "biue", "9.6.", "9249.", "Thymol", "Carbonate.", "Thymotal;", "Tyratol.", "CyH04", "mol", "wt", "326.42.", "C", "77.27%,", "H", "8.03%,", "O", "14.70%.", "(CpyHy,O);-", "€O.", "White", "crystals;", "thymol", "odor;", "volatilizes", "with", "steam.", "mp", "49\"", "lnsol", "in", "water,", "acids", "or", "alkalies;", "sol", "in", "hot", "alcohol,", "chlaroform,", "ether,", "carbon", "tetrachloride.", "THERAP", "CAT:", "Anthelmintic.", "9250.", "Thymol", "lodide.", "4,", "‘-", "Bis(iodooxy)-", "2.2«", "dimethyl-", "5.5~", "bistI-methylethyl)-", "1,1~", "biphenyl;", "bithymol", "diiodide;", "thymol", "diiodide;", "diiododithymol;", "Aristol;", "Annidalin;", "Iodi", "tol;", "Iodathymok;", "lodosal;", "1osol;", "Tothymol;", "Thymiode;", "Thy-", "miodol;", "Thymodin.", "CpH,,[,0,", "mol", "wt", "550.23.", "C", "43.65%,", "Consult", "the", "cross", "index", "before", "using", "this", "section.", "Page", "1347", "e£erIcTLe" ]

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[ "9880", "Iv.", "YOLUMETRIC", "SHIFTING" ]

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[ "estimates", "in", "the", "former", "settings", "may", "re-", "flect", "chance,", "some", "recall", "bias,", "or", "the", "po-", "tential", "for", "a", "larger", "number", "of", "smokers", "and", "smoke", "exposures", "in", "these", "settings.", "Workplace", "ETS", "exposure", "has", "received", "less", "attention", "than", "domestic", "ETS", "expo-", "sure", "in", "studies", "of", "lung", "cancer", "to", "date;", "however,", "monitoring", "of", "ETS", "or", "its", "con-", "stituents", "in", "workplace", "settings", "has", "dem-", "onstrated", "detectable", "markers", "of", "ETS", "by", "personal", "air", "monitoring", "and", "biomarkers", "with", "average", "concentrations", "similar", "to", "residential", "levels", "but", "with", "higher", "maxi-", "mum", "values.!", "In", "a", "study", "of", "workplace", "ETS,", "the", "correlation", "between", "number", "of", "smokers", "encountered", "during", "a", "workshitt", "and", "personal", "sampler", "nicotine", "concentra-", "tion", "(micrograms", "per", "cubic", "meter)", "was", "0.62", "(P<.05)", "and", "with", "postshift", "urinary", "cotinine", "was", "0.63", "(P<.05).*", "Brunnemann", "et", "al®", "sampled", "indoor", "air", "in", "bars,", "restau-", "rants,", "and", "trains", "and", "found", "carcinogenie", "tobacco-specific", "N-nitrosamines", "at", "con-", "centrations", "up", "to", "23", "pg/Li", "of", "N'-nitroso-", "nornicotine", "and", "29", "pg/L", "of", "4-(methylnit-", "rosamino)-1-(3", "pyridyl)-1-butanone.", "These", "settings", "serve", "as", "workplaces", "for", "employ-", "ees", "and", "social", "settings", "for", "patrons.", "The", "significant", "elevated", "risk", "of", "lung", "cancer", "in", "this", "study", "associated", "with", "exposures", "out-", "side", "the", "home", "suggests", "the", "importance", "of", "these", "settings,", "in", "addition", "to", "spousal", "ETS", "exposure,", "in", "the", "United", "States.", "The", "findings", "of", "this", "study", "support", "the", "conclusion", "that", "long-term", "exposure", "to", "ETS", "increases", "risk", "of", "lung", "cancer", "in", "women", "who", "have", "never", "personally", "used", "tobacco.", "This", "increased", "risk", "is", "more", "marked", "for", "women", "who", "have", "also", "been", "exposed", "to", "ETS", "during", "childhood.", "This", "research", "was", "supported", "by", "grant", "CA40095", "from", "the", "National", "Cancer", "Institute,", "Bethesda,", "Md,", "with", "additional", "support", "from", "the", "Louisiana", "Cancer", "and", "Lung", "Trust", "Fund", "Board", "and", "the", "Louisiana", "State", "University", "Stanley", "S.", "Seott", "Cancer", "Center,", "New", "Orleans.", "The", "authors", "are", "grateful", "for", "the", "cooperation", "of", "all", "of", "the", "participating", "hospitals", "in", "the", "five", "study", "areas", "and", "the", "many", "physicians", "who", "helped", "make", "this", "study", "possible.", "The", "authors", "also", "thank", "Gladys", "Block,", "PhD,", "for", "her", "thoughtful", "comments", "and", "sug-", "gestions,", "particularly", "related", "to", "dietary", "exposures;", "S.", "Donald", "Greenberg,", "MD,", "for", "the", "microscopic", "re-", "view", "of", "diagnostic", "material;", "Christopher", "Powers,", "MS,", "Gail", "Smith,", "Mahboob", "Sobhan,", "PhD,", "and", "Wil-", "liam", "Johnson,", "MS,", "for", "programming", "and", "analytic", "support;", "Laurel", "Cederquist,", "MS,", "Annie", "Fung,", "Judy", "Goldstein,", "Helen", "Gregory,", "and", "Anne", "Morse", "for", "field", "supervision;", "the", "American", "Health", "Foundation", "for", "condueting", "the", "urinary", "cotinine", "analyses;", "and", "the", "dedicated", "medical", "record", "abstractors", "and", "inter-", "viewers", "in", "each", "study", "center.", "References", "1.", "Office", "of", "Health", "and", "Environmental", "Assessment,", "Office", "of", "Research", "and", "Development.", "Respiratory", "Health", "Effects", "of", "Passive", "Smoking:", "Lung", "Cancer", "and", "Other", "Disorders.", "Washington,", "DC:", "US", "Envi-", "ronmental", "Protection", "Agency;", "1992.", "2.", "Fontham", "ETH,", "Correa", "P,", "Wu-Williams", "A,", "et", "al.", "Lung", "eancer", "in", "nonsmoking", "women:", "a", "muiticenter", "case-control", "study.", "Cancer", "Epidemiol", "Biomarkers", "Prev.", "1991;1:35-43.", "JAMA,", "June", "8,", "1994—Vol", "271,", "No.", "22", "|", "QO", ".", "Akiba", "JD,", "Kato", "H,", ";", ".", "ind.\\’h\\lng", "cancer", "mongB}Z;XgéePamsrggzng", "Res.", "1986;46:4804~1807.", "’", "4.", "Brownson", "RD,", "Reif", "JS,", "Keefe", "TJ,", "Ferguson", "SW,", "Pritzl", "JA.", "Risk", "factors", "for", "adenomcmguna", "of", "the", "lung.", "Am", "J", "Epidemiol.", "1987;125:25.34,", "5.", "Buffler", "PA,", "Pickle", "LW,", "Mason", "TJ,", "Contant", "C.", "The", "causes", "of", "lung", "cancer", "in", "Texas.", "In:", "Mizell", "M,", "Correa", "P,", "eds.", "Lung", "Cancer:", "Causes", "and", "Preven-", "tion.", "New", "York,", "NY:", "Verlag", "Chemie", "International", "Inc;", "1984:83-99.", "6.", "Chan", "WD,", "Fung", "SC.", "Lung", "cancer", "in", "nonsmokers", "in", "Hong", "Kong.", "In:", "Grundmann", "E,", "ed.", "Cancer", "Cam-", "paign,", "VI:", "Cancer", "Epidemiology.", "Stuttgart,", "Ger-", "many:", "Gustav", "Fischer", "Verlag;", "1982:199-202.", "7.", "Correa", "P,", "Fontham", "E,", "Pickle", "L,", "Lin", "¥,", "Haenszel", "W.", "Passive", "smoking", "and", "lung", "cancer.", "Lancet.", "1983;", "2:595-597.", "8.", "Gao", "Y,", "Blot", "WJ,", "Zheng", "W,", "et", "al.", "Lung", "cancer", "among", "Chinese", "women.", "Int", "J", "Cancer.", "1987;40:604-", "609.", "9.", "Garfinkel", "L,", "Auerbach", "O,", "Joubert", "L.", "Involun-", "tary", "smoking", "and", "lung", "cancer:", "a", "case-control", "study.", "J", "Natl", "Cancer", "Inst,", "1985;75:463-169.", "10.", "Geng", "G,", "Liang", "ZH,", "Zhang", "GL.", "On", "the", "relation-", "ship", "between", "smoking", "and", "female", "lung", "cancer.", "In:", "M,", "Hisamichi", "S,", "Tominaga", "S,", "eds.", "Smoking", "and", "Health.", "Amsterdam,", "the", "Netherlands:", "Elsevier", "Science", "Publishers;", "1988:483-486.", "11.", "Humble", "CG,", "Samet", "JM,", "Pathak", "DR.", "Marriage", "to", "a", "smoker", "and", "lung", "cancer", "risk.", "Am", "J", "Public", "Health.", "1987;77:598-602.", "Inoue", "R,", "Hirayama", "T.", "Passive", "smoking", "and", "lung", "eancer", "in", "women.", "In:", "Aoki", "M,", "Hisamichi", "S,", "Tominaga", "S,", "eds.", "Smoking", "and", "Health.", "Amsterdam,", "the", "Neth-", "erlands:", "Elsevier", "Science", "Publishers;", "1988:283-285,", "13.", "Janerich", "DT,", "Thompson", "WD,", "Varela", "LR,", "et", "al.", "Lung", "cancer", "and", "exposure", "to", "tobacco", "smoke", "in", "the", "household.", "N", "Engl", "J", "Med.", "1990;323:632-636.", "14.", "Kabat", "GC,", "Wynder", "EL.", "Lung", "cancer", "in", "non-", "smokers.", "Cancer.", "1984;53:1214-1221.", "15.", "Kalandidi", "A,", "Katsouyanni", "K,", "Volopoulou", "N,", "et", "al.", "Passive", "smoking", "and", "diet", "in", "the", "etiology", "of", "lung", "can-", "ceramong", "nonsmokers.", "Cancer", "Causes", "Control.", "1990;", "1:15-21.", "16.", "Xoo", "LC,HoJH,", "Saw", "D,", "Ho", "CY.", "Measurements", "of", "passive", "smoking", "and", "estimates", "of", "lung", "cancer", "risk", "among", "nonsmoking", "Chinese", "females.", "Int", "J", "Can-", "cer.", "1987;39:162-169.", "17.", "Lam", "TH,", "Kung", "ITM,", "Wong", "CM,", "et", "al.", "Smoking,", "passive", "smoking,", "and", "histological", "types", "in", "lung", "eancer", "in", "Hong", "Kong", "Chinese", "women.", "Br", "J", "Cancer.", "1987;6:", "673-678.", "18.", "Lam", "WK.", "A", "Clinical", "and", "Epidemiological", "Study", "of", "Carcinoma", "of", "the", "Lung", "in", "Hong", "Kong.", "Hong", "Kong:", "University", "of", "Hong", "Kong;", "1985.", "Thesis.", "19.", "Lee", "PN,", "Chamberlain", "J,", "Alderson", "MR.", "Rela-", "tionship", "of", "passive", "smoking", "to", "risk", "of", "lung", "cancer", "and", "other", "smoking-associated", "diseases.", "Br", "J", "Can-", "cer.", "1986;54:97-105.", "20.", "Liu", "Z,", "He", "X,", "Chapman", "RS.", "Smoking", "and", "other", "risk", "factors", "for", "lung", "cancer", "in", "Xuanwei,", "China.", "Int", "J", "Epidemiol.", "1991;20:26-31.", "21.", "Pershagen", "G,", "Hrubec", "Z,", "Svensson", "C.", "Passive", "smoking", "and", "lung", "cancer", "in", "Swedish", "women.", "Am", ".J", "Epidemiol.", "198T;125:17-24.", "22.", "Shimizu", "H,", "Morishita", "M,", "Mizuno", "K,", "et", "al.", "A", "case-control", "study", "of", "lung", "cancer", "in", "nonsmoking", "women.", "Tohokwu", "J", "Exp", "Med.", "1988;154:389-397.", "23.", "Sobue", "T,", "Suzuki", "R,", "Nakayama", "N,", "et", "2.", "Passive", "smoking", "among", "nonsmoking", "women", "and", "the", "rela-", "tionship", "between", "indoor", "air", "pollution", "and", "lung", "can-", "cer", "incidence.", "Gan", "No", "Rinsho.", "1990;36:329-333.", "24.", "Svensson", "C,", "Pershagen", "G,", "Klominek", "J.", "Smok-", "ing", "and", "passive", "smoking", "in", "relation", "to", "lung", "cancer", "in", "women.", "Acta", "Oncol.", "1989;28:623-629.", "25.", "Trichopoulos", "D,", "Kalandidi", "A,", "Sparros", "L.", "Lung", "cancer", "and", "passive", "smoking.", "Lancet.", "1983;2:667-668.", "26.", "Wu", "AH,", "Henderson", "BE,", "Pike", "MD,", "Yu", "MC.", "Smok-", "ing", "and", "other", "risk", "factors", "for", "lung", "cancer", "In", "women.", "J", "Natl", "Cancer", "Inst.", "1985;74:747-751.", "27.", "Wu-Williams", "AH,", "Samet", "JH.", "Enw.:onm_ent.al", "tobaceo", "smoke:", "exposure-response", "relationships", "in", "epidemiologic", "studies.", "Risk", "Anal:", "1990;10:39-48.", "28.", "Butler", "TL.", "The", "Relationship", "of", "Passive", "Smok-", "ing", "to", "Various", "Health", "Outcomes", "Among", "Seventh-", "Day", "Adventists", "in", "California.", "Los", "Angeles:", "Uni-", "versity", "of", "California~Los", "Angeles;", "1988.", "Thesis.", "29.", "Garfinkel", "L.", "Time", "trends", "in", "lung", "cancer", "mortality", "among", "nonsmokers", "and", "a", "note", "on", "passive", "smoking.", "J", "Natl", "Cancer", "Inst.", "1981;6:1061-1066.", "30.", "Hirayama", "T.", "Cancer", "mortality", "in", "nonsmoking", "women", "with", "smoking", "husbands", "based", "on", "a", "large-scale", "cohort", "study", "in", "Japan.", "Prev", "Med.", "1984;13:680-690.", "31.", "Hole", "DJ,", "Gillis", "CR,", "Chopra", "C,", "Hawthorne", "VM.", "Passive", "smoking", "and", "cardiorespiratory", "healthina", "general", "population", "in", "the", "west", "of", "Scotland.", "BMJ.", "1989;299:423-427,", ".", "32.", "Brownson", "RC,", "Alavanja", "MC,", "Hock", "ET,", "Loy", "TS.", "Passive", "smoking", "and", "lung", "cancer", "in", "nonsmok-", "ing", "women.", "Am", "J", "Public", "Health.", "1992;32:1525-1530.", "33.", "Stockwell", 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"Saloojee", "Y.", "Comparison", "of", "tests", "used", "to", "distinguish", "smokers", "from", "nonsmokers.", "Am", "J", "Pub-", "lic", "Health.", "1987;77:1435-1438.", "38.", "Haley", "NJ,", "Colosimo", "SG,", "Axelrad", "CM,", "Harris", "R,", "Sepkovie", "DW.", "Biochemical", "validation", "of", "self-re-", "ported", "exposure", "to", "environmental", "tobacco", "smoke.", "Environ", "Research.", "1989;49:127-135.", "39.", "Hoffmann", "DW,", "Haley", "NJ,", "Adams", "JW,", "Brun-", "neman", "KD.", "Tobacco", "sidestream", "smoke:", "uptake", "by", "nonsmokers.", "Prev", "Med.", "1984;13:608-617.", "40.", "Mattsen", "ME,", "Boyd", "G,", "Boyd", "D,", "et", "al.", "Passive", "smoking", "on", "commercial", "airline", "flights.", "JAMA.", "1989;", "261:867-872.", "41,", "Sehlesselmann", "JJ.", "Case-Control", "Studies:", "De-", "sign,", "Conduct,", "Analysis.", "New", "York,", "NY:", "Oxford", "University", "Press;", "1982.", ")", "42,", "Kleinbaum", "DG,", "Kupper", "LL,", "Morgenstern", "H.", "Epi-", "demiologic", "Research:", "Principles", "and", "Quantitative", "Methods.", "Belmont,", "Calif:", "Lifetime", "Learning", "Publica-", "tions;", "1982.", "43.", "Ries", "LAG,", "Hankey", "BF,", "Miller", "BA,", "Hartman", "AM,", "Edwards", "BK.", "Cancer", "Statistics", "Review", "1973-", "88.", "Bethesda,", "Md:", "National", "Cancer", "Institute;", "1991:", "152-V123.", "NTH", "publication", "91-2789.", "44,", "Committee", "on", "Passive", "Smoking,", "Board", "on", "Envi-", "ronmental", "Studies", "and", "Toxicology,", "National", "Research", "Council.", "Environmental", "Tobacco", "Smoke:", "Measuring", "Exposures", "and", "Assessing", "Health", "Effects.", "Washing-", "ton,", "DC:", "National", "Academy", "Press;", "1986.", "45.", "Wynder", "EL,", "Goodman", "MT.", "Smoking", "and", "lung", "cancer:", "some", "unresolved", "issues.", "Epidemiol", "Rev.", "1983;", "5:177-207.", "46.", "Pron", "GE,", "Burch", "JB,", "Howe", "GR,", "Miller", "AB.", "The", "reliability", "of", "passive", "smoking", "histories", "reported", "in", "a", "case-control", "study", "of", "lung", "cancer.", "Am", "J", "Epide-", "miol.", "1988;127:267-273.", "47.", "Coultas", "DB,", "Peake", "GT,", "Samet", "JM.", "Question-", "naire", "assessment", "of", "lifetime", "and", "recent", "exposure", "to", "environmental", "tobacco", "smoke.", "Am", "J", "Epidemiol.", "1989:130:338-347.", "48.", "LeMarchand", "L,", "Wilkins", "LR,", "Hankin", "JH,", "Haley", "NJ.", "Dietary", "patterns", "of", "female", "nonsmokers", "with", "and", "without", "exposure", "to", "environmental", "tobacco", "smoke.", "Cancer", "Causes", "Control.", "1991;2:11-16.", "49.", "Coultas", "DB,", "Samet", "JM,", "McCarthy", "JF,", "Spen-", "gler", "JD.", "A", "personal", "monitoring", "study", "to", "assess", "workplace", "exposure", "to", "environmental", "tobacco", "smoke.", "Am", "J", "Public", "Health.", "1990;80:988-990.", "50.", "Brunnemann", "KD,", "Cox", "JE,", "Hoffmann", "D.", "Analy-", "sis", "of", "tobacco-specific", "N’-nitrosamines", "in", "indoor", "air.", "Carcinagenesis.", "1992;13:2415-2418.", "Tobacco", "Smoke", "and", "Lung", "Cancer-—Fontham", "et", "al", "1759", "€11L68890z", "hIIi..IlIIIlIlIIIllIllllllIIIlIIlIIIIlllIIIlllllllIIIIIIIlll------------—-—-" ]

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"modem", "varsus", "old", "barracks.®", "Dr.", "Brundage", "pointed", "out", "the", "significance", "of", "these", "findings", "for", "energy", "conservation", "measures", "which", "would", "reduce", "ventilation", "rates.", "He", "noted", "that", "ARDS", "in", "the", "United", "States", "are", "annually", "associated", "with", "some", "75", "million", "physician", "visits,", "1.25", "million", "hospitalizations,", "$15", "billion", "in", "direct", "medical", "costs,", "150", "million", "lost", "workdays,", "and", "at", "least", "$59", "billion", "in", "lost", "income.", "These", "figures", "can", "probabtly", "be", "divided", "by", "a", "factor", "of", "10", "to", "apply", "to", "Canada.", "In", "1989,", "the", "American", "Society", "of", "Heating,", "Refrigarating", "and", "Air-", "Conditioning", "Engineers", "(ASHRAE)}", "issued", "a", "revised", "ventilation", "standard", "whichincreased", "the", "minimum", "building", "ventilation", "rate", "from", "5o", "15", "cubic", "feet", "of", "outside", "air", "per", "minute", "for", "each", "persan.", "in", "1990,", "the", "National", "Building", "Code,", "in", "light", "of", "the", "increasing", "air", "tightness", "of", "houses", "in", "Canada,", "and", "related", "‘concems", "over", "indoor", "air", "quality", "and", "excessive", "humidity", "in", "winter,", "instituted", "a", "requirement", "that", "new,", "self-contained", "dwetling", "units", "have", "mechanical", "ventilation", "systems.", "The", "Sth", "International", "Conference", "on", "Indoor", "Air", "Quality", "and", "Climate:", "INDOOR", "AIR", "'90,", "heid", "in", "Toromo", "in", "the", "summer", "of", "1990,", "attracted", "the", "largest", "yet", "scientific", "gathering", "in", "the", "fieid", "with", "nearly", "1,300", "participants", "At", "the", "Cantre,", "April", "1991", "from", "35", "nations.", "Over", "540", "papers", "were", "presented", "including", "the", "papers", "previousiy", "noted.", "As", "well:", "«", "Dales", "et", "al", "of", "Health", "and", "Welfars", "Canadareportedthatthe", "presence", "of", "moisture", "problems", "and", "mold", "in", "38", "per", "cent", "of", "1,600", "Canadian", "homes", "surveyed", "was", "linked", "with", "a", "50-60", "per", "cent", "increase", "in", "respiratory", "problems", "(cough,", "cough", "with", "phiegm,", "wheeze,", "wheeze", "with", "dyspneay);", "'+", "Gravesen", "et", "al", "of", "Denmark", "reported", "that", "macromolecular", "organic", "dust", "(primarily", "proteins)", "is", "associated", "with", "the", "Sick", "Building", "Syndrome", "in", "offices", "they", "have", "studied", "in", "Denmark,", "and", "recommended", "that", "the", "use", "of", "carpet,", "especially", "in", "heavy", "traffic", "areas,", "be", "minimized;", "»", "Burge", "and", "Harrison", "of", "the", "United", "Kingdom", "reponted", "that", "the", "SBS", "is", "more", "prevalent", "in", "offices", "which", "have", "non-openable", "windows", "and", "are", "mechanically", "ventilated", "than", "in", "those", "with", "openable", "windows;", "«", "Seifertofthe", "Federal", "Heaith", "Office", "inGermany", "calledfor", "the", "issuance", "of", "guidelines", "for", "acceptable", "pollutant", "levels", "in", "indoor", "air", "and", "emission", "standards", "for", "products", "and", "materials.", "Dr.", "Seifert", "noted", "that", "the", "best", "approach", "to", "reducing", "indoor", "air", "poliution", "is", "through", "control", "at", "source", "and", "that", "as", "a", "first", "step", "towards", "this", "goal", "the", "Council", "of", "European", "Communities", "has", "issued", "a", "directive", "on", "construction", "products", "dealing", "with", "such", "concems", "as", "toxic", "gas", "emissions,", "In", "1991,", "Dr.", "Nicholas", "Ashford", "of", "the", "Massachussetts", "Institute", "of", "Technology", "in", "his", "keynote", "address", "to", "Labour", "Canada's", "Conference", "on", "Workplace", "Safety", "and", "Health:", "the", "21st", "Century,", "observed", "that", "the", "chemicals", "indoors", "are", "ubiquitous", "and", "pose", "a", "potential", "risk", "of", "populdtion", "sensilization", "on", "a", "massive", "scale.", "Canadian", "measurements", "of", "indoor", "concentrations", "of", "volatile", "organic", "mixtures,", "for", "example,", "in", "our", "best", "buildings", "and", "homes", "are", "normally", "four", "times", "those", "found", "n", "the", "air", "outside.", "with", "many", "buildings", "having", "levels", "50", "or", "more", "times", "higher", "than", "those", "outdoors.", "The", "trend", "is", "clear.", "Indoor", "environments,", "and", "material", "and", "preduct", "emissions", "indoors,", "will", "be", "regulated.", "1t", "is", "only", "a", "guestion", "of", "when", "and", "by", "what", "means.", "Obviously,", "concentration", "criteria", "based", "on", "all", "acute", "and", "chronic", "heaith", "effects", "are", "best.", "However,", "there", "are", "so", "many", "air", "pollutants", "and", "combinations", "thereof,", "the", "exposures", "so", "widespread,", "and", "the", "studies", "50", "costly", "that", "such", "heaith", "data", "will", "be", "some", "time", "in", "coming", "for", "the", "majority", "of", "poilutants.", "In", "the", "meantime,", "what", "do", "we", "do?", "Common", "sense", "says", "that", "we", "should", "aim", "to", "create", "environments", "with", "the", "lowest", "poliutant", "exposures", "practically", "achigvable", "using", "comfort,", "odour", "and", "productivity.", "effects", "along", "with", "environmental", "measurements", "comparing", "indoor", "to", "outdoor", "leveis", "as", "indicators", "of", "success.", "However,", "for", "specific", "pollutants,", "exposures", "which", "are", "practically", "achievabie", "in", "non-industrial", "environments", "suchas", "the", "office,", "school", "or", "home", "can", "be", "substantially", "lower", "than", "for", "industria", "environments", "where", "these", "poliutants", "areintegral", "to", "the", "production", "process.", "On", "this", "basis", "then,", "different", "poliution", "criteria", "should", "be", "set", "for", "different", "genericindoor", "spaces.", "Untiithe", "higher", "exposures", "canbe", "shown", "tobe", "equally", "sate,", "there", "is", "no", "reasonable", "alternative", "to", "muitiple", "standards", "based", "on", "practicability.", "Who", "should", "decide", "what", "is", "practical?", "Health", "scientists", "should", "not", "for", "they", "have", "no", "responsibility", "for", "building", "codes.", "Industries", "cannot", "because", "they", "have", "various", "vested", "interests.", "Practically", "achievable", "poilution", "levels", "can", "only", "be", "decided", "through", "a", "muiti-disciplinary", "consensus", "approach,", "with", "industry", "representatives", "working", "together", "with", "‘building,", "environmental", "and", "heaith", "Such", "consensus", "is", "perhaps", "best", "achieved", "through", "protessionat", "associations.", "The", "North", "American", "19", "6celess0se" ]

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[ "121.", "122.", "123.", "124.", "125,", "126.", "127.", "128.", "129.", "130,", "131.", "McCarthy,", "C.,", "Laguarda,", "R.,", "Sobel,", "K.,", "Nicholas,", "H.,", "Pollack,", "C.,", "Simmonms,", "G.,", "Mullane,", "J.", "and", "Huber,", "G.:", "An", "experimental", "evaluation", "of", "therapeutic", "measures", "used", "in", "the", "treatment", "of", "aspiration", "pneumo-", "nitis.", "Clin.", "Res.", "22:450,", "1974,", "Cutting,", "M.,", "Watson,", "A.,", "Goodenough,", "S.,", "Simmons,", "G.,", "Laguarda,", "R.", "and", "Huber,", "G.:", "The", "effect", "of", "exposure", "to", "marijuana", "smoke", "on", "the", "bactericidal", "activity", "of", "pulmonary", "alveolar", "macrophages.", "Clin.", "Res.", "22:501,", "1974", "Cutting,", "M.,", "Watson,", "A.,", "Goodenough,", "S.,", "Simmons,", "G.,", "Laguarda,", "R.", "and", "Huber,", "G.:", "Impairment", "of", "alveolar", "macrophage", "bactericidal", "activity", "by", "synthetic", "tobacco", "substitutes.", "Am.", "Rev.", "Resp.", "Dis.", "109:726-727,", "1974.", "Huber,", "G.,", "McCarthy,", "C.,", "Simmons,", "G.,", "Finder,", "E.,", "Mullane,", "J.,", "Laguarda,", "R.", "and", "LaForce,", "M.:", "Oyxgen", "toxicity", "and", "bacterial", "infection", "in", "the", "lung.", "Chest", "65(5):", "589-590,", "1974,", "McCarthy,", "C.,", "Simmons,", "G.:", "The", "effect", "of", "supplemental", "oxygenation", "on", "the", "antibacterial", "host", "defense", "networks", "of", "the", "lung.", "Preprints", "of", "1974", "Scientific", "Program", "of", "the", "Aerospace", "Med.", "Assoc,", "1:71,", "1974,", "Cutting,", "M.", "Watson,", "A.,", "Goodenough,", "S.,", "Simmons,", "G.,", "Laguarda,", "R.", "and", "Huber,", "G.:", "Impairment", "of", "bactericidal", "activity", "of", "pulmonary", "alveolar", "macrophages", "by", "exposure", "to", "marijuana", "smoke.", "Proc.", "Int.", "Union", "Physiol.", "Sci.", "21:361,", "1974,", "Roth,", "R.R.,", "Mullane,", "J.F.,", "Huber,", "G.L.,", "Phelps,", "T.0.", "and", "Wilfong,", "R.G.:", "Blood", "loss", "and", "factors", "affecting", "pulmonary", "antibacterial", "defenses.", "J.", "Surg.", "Res.", "17:36-42,", "1974.", "Cutting,", "M.,", "Goodenough,", "S.,", "Simmons,", "G.,", "Watson,", "A.,", "Laguarda,", "R.", "and", "Huber,", "G.:", "Marijuana", "and", "pulmonary", "antibacterial", "defenses:", "Depression", "of", "alveolar", "macrophage", "function", "following", "experimental", "exposure", "to", "marijuana", "smoke.", "Chest", "66:321-322,", "1974.", "Couzens,", "S.,", "Calihan,", "M.,", "lLaguarda,", "R.", "and", "Huber,", "G.:", "Additive,", "potentia-", "ting", "and", "protecting", "effects", "of", "oxygen", "administration", "on", "acute", "lung", "injury.", "Chest", "66:321,", "1974,", "Mullane,", "J.,", "Goodenough,", "S.,", "McCarthy,", "C.,", "Simmons,", "G.,", "O'Comnell,", "D.,", "LaForce,", "M.,", "Laguarda,", "R.", "and", "Huber,", "G.:", "Alterations", "in", "alveolar", "lining", "material", "as", "the", "key", "factor", "in", "depression", "of", "interpulmonary", "antibacterial", "defenses", "following", "stress.", "Chest", "66:333,", "1974.", "Huber,", "G.,", "Schauffier,", "H.,", "McCarthy,", "C.", "and", "Hayashi,", "M.:", "Comparative", "morphometric", "analysis", "of", "recoverable", "and", "in", "situ", "pulmonary", "alveolar", "macrophages.", "J.", "Cell.", "Biol.", "63:148A,", "1974.", "11300130" ]

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[ "1046", "FIGURE", "4.", "Histologic", "analysis", "of", "thymus", "from", "DBA/2", "mice", "with", "syngeneic", "GVHD:", "(A)", "thymus", "from", "control", "group", "(H&E;", "X10);", "and", "(B)", "thymus", "remnant", "from", "CsA-treated", "animal", "(H&E;", "X10).", "Tissue", "samples", "were", "taken", "10", "days", "after", "cessation", "of", "CsA", "treatment.", "syngeneic", "bone", "marrow,", "the", "disease", "may", "develop", "such", "that", "other", "organs", "might", "become", "involved.", "Over", "the", "past", "several", "years,", "there", "has", "been", "substantial", "inter-", "est", "in", "the", "regulation", "and", "function", "of", "autoreactive", "(self-Ia)", "T", "cells", "(34-36).", "All", "the", "target", "organs", "described", "in", "this", "paper", "either", "have", "large", "populations", "of", "class-Il-positive", "cells", "or", "are", "capable", "of", "having", "class", "II", "antigens", "induced", "as", "has", "been", "shown", "for", "the", "intestinal", "epithelium", "during", "GVHD", "(37).", "Therefore,", "the", "lymphocytic", "infiltration", "described", "here", "may", "represent", "an", "Ia-", "specific", "immune", "response.", "With", "recent", "experiments,", "in", "a", "sim-", "TRANSPLANTATION", "Vol.", "48,", "No.", "6", "F1GURE", "5.", "DBA/2", "mice", "with", "syngeneic", "GVHD", "develop", "lesions", "in", "the", "spleen:", "(A)", "spleen", "from", "the", "diluent", "control", "group", "(H&E;", "X50);", "and", "(B)", "lymphoblastoid", "infiltrate", "in", "spleen", "from", "CsA-treated", "animal", "(ar-", "rows)", "(H&E;", "x50).", "The", "insert", "shows", "a", "lower", "magnification", "(H&E;", "X10)", "of", "the", "spleen", "presented", "in", "(B).", "Tissue", "samples", "were", "taken", "34", "days", "after", "cessation", "of", "CsA", "treatment.", "ilar", "murine", "model", "demonstrating", "that", "self-la-reactive", "T", "cells", "escape", "tolerance", "(16,", "17),", "induction", "of", "syngeneic", "GVHD", "with", "CsA", "appears", "to", "be", "a", "model", "well", "suited", "to", "study", "the", "in", "vivo", "development", "and", "function", "of", "autoreactive", "T", "lymphocytes.", "REFERENCES", "1.", "Lillehoj", "HE,", "Malek", "TR,", "Shevach", "EM.", "Differential", "effect", "of", "cyclo-", "sporin-A", "on", "the", "expression", "of", "T", "and", "B", "lymphocyte", "activation", "antigens.", "J", "Immunol", "1984;", "133:", "244." ]

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[ "Carter,", "William,", "M.D.", "OA", "B3", "by", "50222881" ]

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[ "VI.", "PROMOTION", "EFFECTIVENESS" ]

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