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H2KP 1

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"inducing", "nondependent", "rats", "to", "self-administer", "drugs,", "the", "similarity", "of", "environmental", "conditions", "during", "self-administration", "to", "those", "in", "which", "the", "behavior", "was", "originally", "established", "appears", "to", "be", "of", "importance.", "Thompsan", "&", "Ostlund", "(95)", "made", "rats", "physically", "dependent", "on", "marphine", "using", "an", "oral", "administration", "procedure", "similar", "ta", "that", "described", "by", "Nichols,", "Headlee", "&", "Coppock", "(10).", "For", "30", "days", "of", "morphine", "deprivation", "half", "of", "the", "rats", "were", "moved", "to", "a", "different", "room", "and", "placed", "in", "new", "cages", "and", "half", "were", "Ieft", "in", "original", "cages.", "Half", "of", "each", "group", "remained", "in", "the", "same", "cage", "in", "which", "withdrawal", "had", "been", "experienced", "and", "half", "were", "moved", "to", "the", "other", "set", "of", "cages", "during", "the", "readdiction", "phase.", "Over", "3", "weeks", "oral", "preference", "tests", "were", "run", "to", "assess", "relative", "disposition", "to", "ingest", "merphine", "solution:", "Animals", "returned", "to", "the", "same", "environmients", "in", "which", "original", "drug", "admini", "tration", "had", "occurred", "ingested", "significantly", "larger", "amounts", "of", "marphine", "and", "animals", "placed", "in", "an", "environment", "different", "from", "that", "in", "which", "withdrawal", "had", "occurred", "ingested", "relatively", "greater", "amounts", "of", "morphine.", "In", "other", "words,", "the", "tendency", "to", "self-administer", "the", "drug", "is", "greater", "if", "the", "environ-", "ment", "the", "same", "as", "that", "in", "which", "the", "original", "drug-taking", "had", "occurred.", "Conversely,", "placing", "the", "animal", "in", "the", "situation", "where", "withdrawal", "has", "oc-", "curred", "decreases", "the", "probability", "of", "self-administration.", "These", "findings", "have", "intercsting", "parallels", "in", "Vaillant’s", "(96)", "follow-up", "study", "of", "morphine", "and", "heroin", "addicts.", "Addicts", "abstinent", "at", "the", "end", "af", "12", "years", "tended", "to", "have", "un-", "dergone", "in", "theic", "heme", "environment,", "In", "addition,", "many", "of", "those", "that", "were", "abstinent", "lived", "in", "different", "environments", "from", "that", "in", "which", "the", "original", "drug", "dependence", "had", "developed.", "Scliedules", "of", "drug", "reinforcement—The", "specific", "patterning", "of", "behavior", "and", "its", "persistence", "are", "dependent", "to", "a", "large", "degree", "on", "the", "schedule", "of", "rein-", "forcement", "[Skinner", "(97),", "Ferster", "&", "Skinner", "(98),", "Morse", "(99)].", "Thus,", "ane", "might", "expect", "that", "the", "specific", "pattern", "of", "drug-taking", "behavior", "and", "its", "persistence", "would", "depend", "on", "the", "schedule", "of", "reinforcement.", "Most", "studies", "have", "involved", "continnons", "reinforcement,", "i.c.,", "each", "response", "produced", "an", "in-", "Jection", "of", "drug.", "ITowever,", "a", "number", "of", "investigators", "have", "begun", "to", "examine", "intermittent", "schedules", "of", "drug", "reinforcement,", "though", "almost", "exclusively", "fixed-ratio", "schedules,", "Weeks", "(30),", "Weeks", "&", "Collins", "(38,", "100),", "and", "Collins", "&", "Weeks", "(66,", "101)", "have", "studied", "fixed-ratio", "schedules", "of", "morphine,", "dihydro.", "marphinone", "and", "codeine", "reinforcement,", "In", "several", "cases", "only", "one", "value", "of", "ratio", "schedule", "was", "used", "and", "dosage", "per", "infusion", "varied;", "however,", "in", "other", "SELF", "ADMINISTRATION", "OF", "DRUGS", "497", "studies,", "ratios", "were", "varied.", "Pickens", "(51),", "Pickens", "&", "Thompson", "(49,", "50),", "Pickens", "&", "Harris", "(55),", "and", "Pickens,", "Meisch", "&", "McGuire", "(53)", "have", "ex-", "plored", "fixcd-ratio", "schedules", "using", "stimulant", "drug", "reinforcement.", "These", "in-", "vestigators", "have", "varied", "ratios", "(FR", "1", "to", "80)", "over", "a", "range", "of", "dosages", "of", "co-", "caine,", "d-amphetamine", "and", "methamphetamine.", "In", "the", "case", "of", "stimulant", "drugs,", "a", "characteristic", "pattern", "of", "responding", "develops", "with", "runs", "of", "responses", "at", "very", "high", "rates", "followed", "by", "long", "periods", "without", "responding.", "Thesc", "“pauses”", "are", "related", "both", "to", "the", "value", "of", "the", "ratio", "schedule", "and", "the", "magni-", "tude", "of", "drug", "reinforcement,", "Overall", "response", "rate", "varies", "directly", "with", "the", "size", "of", "the", "ratio,", "aver", "a", "considerable", "range", "of", "ratios.", "Morphine.reinforced", "ratio", "performance", "is", "also", "characterized", "by", "runs", "of", "responses", "at", "high", "rates,", "but", "the", "interinfusion", "interval", "tends", "to", "be", "more", "variable", "[Collins", "&", "Weeks", "(40)].", "The", "only", "other", "simple", "intermittent", "schedule", "of", "drug", "reinfarcement", "re-", "ported", "is", "a", "variable-interval", "schedule.", "Woods", "&", "Schuster", "(41)", "have", "ex-", "plored", "morphine", "self-administration", "by", "markeys", "over", "a", "range", "of", "doses", "and", "found", "that", "a", "very", "characteristic", "constant", "low", "rate", "is", "generated.", "The", "mon-", "keys'", "response-rates", "for", "morphine", "were", "consistently", "lower", "than", "their", "re-", "sponse-tates", "fur", "food", "reinforcement.", "Two", "studies", "have", "been", "reported", "involving", "move", "complex", "schedules.", "Thompson", "&", "Schuster", "(39)", "used", "a", "fixed-interval-fixed-ratio", "chained", "sched-", "wle", "of", "intravenous", "morphine", "reinforcement", "with", "monkeys.", "The", "behavior", "de-", "veloped", "some", "characteristics", "of", "chained", "schedules", "commaonly", "observed", "using", "other", "reinforcers.", "Recent", "investigations", "of", "highly", "complex", "multioperant", "sc-", "quences", "in", "which", "morphine", "is", "the", "terminal", "reinforeer", "have", "been", "described", "Ly", "Thompson", "&", "Pickens", "(35).", "In", "this", "case", "monkeys", "performed", "a", "chain", "of", "heterogeneous", "responses", "beginning", "with", "standing", "on", "a", "platform", "scale,", "fol-", "lowed", "hy", "opening", "and", "clasing", "a", "door", "to", "a", "compartment", "in", "which", "morphine", "is", "infused,", "cooperating", "with", "anather", "monkey", "in", "holding", "a", "switch", "closed,", "and", "finally,", "operating", "2", "lever", "on", "a", "fixed-ratio", "schedule", "for", "intravenous", "mor-", "yhine.", "This", "schedule", "is", "well", "maintained,", "with", "pausing", "during", "the", "early", "com-", "potents", "varying", 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