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30fb07a681559b001d48cd2abc9b4c78b59435ba | DNA capture by a CRISPR-Cas9–guided adenine base editor | Secrets of a fast base editor CRISPR-Cas9 base editors comprise RNA-guided Cas proteins fused to an enzyme that can deaminate a DNA nucleoside. No natural enzyme deaminates adenine in DNA, and so a breakthrough came when a natural transfer RNA deaminase was fused to Cas9 and evolved to give an adenine base editor (ABE) that works on DNA. Further evolution provided the enzyme ABE8e, which catalyzes deamination more than 1000 times faster than early ABEs. Lapinaite et al. now present a 3.2-angstrom resolution structure of ABE8e bound to DNA in which the target adenine is replaced with an analog designed to trap the catalytic conformation. The structure, together with kinetic data comparing ABE8e to earlier ABEs, explains how ABE8e edits DNA bases and could inform future base-editor design. Science, this issue p. 566 A cryo–electron microscopy structure of the base editor ABE8e in a substrate-bound state elucidates base-editing mechanisms. CRISPR-Cas–guided base editors convert A•T to G•C, or C•G to T•A, in cellular DNA for precision genome editing. To understand the molecular basis for DNA adenosine deamination by adenine base editors (ABEs), we determined a 3.2-angstrom resolution cryo–electron microscopy structure of ABE8e in a substrate-bound state in which the deaminase domain engages DNA exposed within the CRISPR-Cas9 R-loop complex. Kinetic and structural data suggest that ABE8e catalyzes DNA deamination up to ~1100-fold faster than earlier ABEs because of mutations that stabilize DNA substrates in a constrained, transfer RNA–like conformation. Furthermore, ABE8e’s accelerated DNA deamination suggests a previously unobserved transient DNA melting that may occur during double-stranded DNA surveillance by CRISPR-Cas9. These results explain ABE8e-mediated base-editing outcomes and inform the future design of base editors. | [] | https://semanticscholar.org/paper/30fb07a681559b001d48cd2abc9b4c78b59435ba | [] | [
{
"name": "Audrone Lapinaite",
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{
"name": "Gavin J. Knott",
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},
{
"name": "Cody M. Palumbo",
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},
{
"name": "Enrique Lin-Shiao",
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},
{
"name": "Michelle F. Richter",
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},
{
"name": "Kevin T. Zhao",
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},
{
"name": "Peter A. Beal",
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},
{
"name": "David R. Liu",
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},
{
"name": "Jennifer A. Doudna",
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] | [
"Chemistry",
"Medicine"
] | 2,020 | Science | Science | 369 | 566 - 571 | [
"Medline"
] | 10.1126/science.abb1390 | https://doi.org/10.1126/science.abb1390 | 32732424 | 3046580469 |
|
0565c45dd6f8e03884477b011abaf601f7571dfb | Design of MM440 Inverter Remote Control Based On PROFIBUS DP | SIEMENS MM440 inverter not only has a good operating reliability and diverse control functions, but also has a strong communication function.After installing the PROFIBUS module, the MM440 can access the high speed DP communication network to realize the remote control. This paper introduces the design scheme of the control system of MM440 based on the PROFIBUS DP bus remote control system using the SIEMENS S7-300 series PLC. The scheme is divided into two parts, hardware design and software design. The experimental results show that it can achieve remote control of MM440. | [] | https://semanticscholar.org/paper/0565c45dd6f8e03884477b011abaf601f7571dfb | [] | [
{
"name": "Ge Da-we",
"ids": [
"1449758519"
]
}
] | [] | [] | [
"Engineering"
] | 2,015 | Science & Technology Vision | [] | 2390714595 |
|||||||
60d09b8578ef45266f9befdc135bc225b7e24ddd | Soil Nail Supportment as Form of External Wall of Basement in Waterproof Construction | In waterproof construction underground,when soil nail supportment is made as form of external wall of basement, it can decrease earthwork, save formwork andcost if reasonably selected materials and scientifically orgnised construction, especially on condition of construction space is limited or time limit for a project is not e-nough. | [] | https://semanticscholar.org/paper/60d09b8578ef45266f9befdc135bc225b7e24ddd | [] | [
{
"name": "Qian Kun",
"ids": [
"48729375"
]
}
] | [] | [] | [
"Engineering"
] | 2,003 | [] | 2353759562 |
||||||||
29177cb0814b2a94405aed1c8952b2be9d69e5f7 | Semigroup Method in Combinatorics on Words | Semigroup method and Combinatorics method are two important techniques in the study of words and languages. This paper presents the semigroup method and explore languages by using semigroup method. Some algebraic properties of languages be given via semigroup method. Firstly, the semigroup constructions of dense languages are given. It’s proved that every dense language which syntactic monoid has the zero, or which syntactic monoid has the minimal ideal and this ideal is a periodic semigroup having a primitive idempotent contains a language w(w k) * for some nonempty word w and some positive integer k. The theorem every code is thin is generalized to the result that every code which syntactic monoid has the zero, or which syntactic monoid has the minimal ideal and this ideal is a periodic semigroup having a primitive idempotent is thin. It’s proved that every dense regular language contains a product of some word with some dense regular right unitary submonoid of A *, and by using this result it is proved that every dense regular language also contains a primitive word. Secondly, the regular component decomposition of free monoids are given. It’s proved that free monoids are regular component splittable and that every product of a regular component splittable language with a regular component splittable suffix language is regular component splittable. As applications of the above results two conjectures about regular languages given by Shyr and Yu, in 1998 are proved. The two conjectures are that regular languages are regular component splittable and dense regular languages contains imprimitive words. | [] | https://semanticscholar.org/paper/29177cb0814b2a94405aed1c8952b2be9d69e5f7 | [] | [
{
"name": "Liu Yao",
"ids": [
"145272386"
]
}
] | [
"9bd225df2ee332cd0169452262d43ff76730d11f"
] | [] | [
"Mathematics"
] | 2,005 | Chinese Journal of Computers | [] | 2369303992 |
|||||||
f0a8a4c93813e984cdabe1e2a2afbf92ca164610 | UPPER LIMITS ON THE ATOMIC HYDROGEN ABUNDANCE IN 12 GLOBULAR CLUSTERS. | Description of 21-cm neutral-hydrogen line observations of 12 globular clusters performed with negative results by means of the NRAO 140-ft telescope. Limits on the atomic hydrogen content yielded by these observations over a range of 11 to 85 solar masses are presented.- | [] | https://semanticscholar.org/paper/f0a8a4c93813e984cdabe1e2a2afbf92ca164610 | [] | [
{
"name": "F. J. Kerr",
"ids": [
"66031414"
]
},
{
"name": "G. R. Knapp",
"ids": [
"88750573"
]
}
] | [
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"a23aa07d577a699d24e52603329cd3cd535d75af",
"a08617185154037d307fee575367455adc4838d8"
] | [] | [
"Physics"
] | 1,972 | The Astronomical Journal | 77 | 573 | [] | 10.1086/111320 | https://doi.org/10.1086/111320 | 2067837912 |
|||
ad49a5c08569cefdea9f7726e970362c415a1817 | Visual literacy and the integration of parametric modeling in the problem-based curriculum | This quasi-experimental study investigated the application of visual literacy skills in the form of parametric modeling software in relation to traditional forms of sketching. The study included two groups of high school technical design students. The control and experimental groups involved in the study consisted of two randomly selected groups of students. The participants were exposed to eight weeks of technical drawing and parametric modeling instruction prior to the start of the study. The potential applications of emerging technologies for the purpose of integrating visual literacy into the curriculum are not fully understood. Society is moving towards a more immediate form of communication (Galante, 2011). Visual forms of communication are becoming more prevalent methods for sending and receiving information. Research suggests that visual literacy skills have a correlation to the ability to problem solve, which ultimately can be beneficial to student learning (Matusitz, 2005). The application of visual literacy skills through the use of parametric modeling software may provide students with better learning experiences in visualization, conceptualization, and communication of images that will allow them to become better problem-solvers. Through this study, the researcher focused on the relationships between the independent and dependent variables in order to perform a statistical analysis of the data. The participants of the study were presented with a pre-test, a treatment, and a post-test relating to visual literacy. The treatment was presented to the participants in the form of a technical design problem that required the participants to apply problem-solving skills in order to devise a solution through the use of either traditional forms of sketching or through the use of parametric modeling. Data were collected and recorded in order to assess the outcome and effects of the variable. Visual Literacy in the Problem-Based Curriculum iii Although the research suggests that there is a correlation between visual literacy skills and the ability to solve problems, this particular study failed to show this correlation. Struggling learners showed no improvement in visualization skills after using parametric modeling software. The two methods used to create the technical design problem showed no statistical significance between the success of the design and the method that was used to create the design. No statistical differences were found between the visualization skills of any of the participants regardless of the methods used in the study. In addition, gender seemed not to be a significant factor in the study when comparing the visualization skills of the participants. There are recommendations, based on the results of this study, for future investigation in this area. Increasing the duration of the study over the course of a school term, could produce different results that were difficult to determine by the limited time constraints of this particular study. Other testing methods could be investigated for future studies that could produce additional information that was not produced in this study. Limiting the prior knowledge of the participants could also produce different results in the outcome of visualization skills. Investigating specific demographics that were not included in this study would also be of interest to be the academic community. Visual Literacy in the Problem-Based Curriculum iv Table of | [] | https://semanticscholar.org/paper/ad49a5c08569cefdea9f7726e970362c415a1817 | [
"https://commons.emich.edu/cgi/viewcontent.cgi?article=1936&context=theses&httpsredir=1&referer="
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{
"name": "Matthew Benedict Assenmacher",
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}
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"Computer Science"
] | 2,013 | [] | 47015482 |
||||||||
7e7c4ce8b2a083ebb8e232f9d7269f62464a0396 | Network anomography | Anomaly detection is a first and important step needed to respond to unexpected problems and to assure high performance and security in IP networks. We introduce a framework and a powerful class of algorithms for network anomography, the problem of inferring network-level anomalies from widely available data aggregates. The framework contains novel algorithms, as well as a recently published approach based on Principal Component Analysis (PCA). Moreover, owing to its clear separation of inference and anomaly detection, the framework opens the door to the creation of whole families of new algorithms. We introduce several such algorithms here, based on ARIMA modeling, the Fourier transform, Wavelets, and Principal Component Analysis. We introduce a new dynamic anomography algorithm, which effectively tracks routing and traffic change, so as to alert with high fidelity on intrinsic changes in network-level traffic, yet not on internal routing changes. An additional benefit of dynamic anomography is that it is robust to missing data, an important operational reality. To the best of our knowledge, this is the first anomography algorithm that can handle routing changes and missing data. To evaluate these algorithms, we used several months of traffic data collected from the Abilene network and from a large Tier-1 ISP network. To compare performance, we use the methodology put forward earlier for the Abilene data set. The findings are encouraging. Among the new algorithms introduced here, we see: high accuracy in detection (few false negatives and few false positives), and high robustness (little performance degradation in the presence of measurement noise, missing data and routing changes). | [] | https://semanticscholar.org/paper/7e7c4ce8b2a083ebb8e232f9d7269f62464a0396 | [
"http://www.maths.adelaide.edu.au/matthew.roughan/Papers/anomography_AusCTW.pdf",
"http://www.cs.utexas.edu/users/yzhang/papers/anomography-tr05.pdf",
"http://conferences.sigcomm.org/imc/2005/papers/imc05efiles/zhang/zhang.pdf",
"http://internal.maths.adelaide.edu.au/people/mroughan/Papers/imc2005.pdf",
"https://www.cs.utexas.edu/~yzhang/papers/anomography-imc05.pdf",
"http://www2.research.att.com/~gezihui/publication/anomographyTR.pdf",
"http://www.eecs.harvard.edu/~mdw/course/cs260r/papers/anomography-imc05.pdf",
"http://www.maths.adelaide.edu.au/people/mroughan/Papers/imc2005.pdf",
"http://www.cs.utexas.edu/ftp/pub/techreports/tr05-38.pdf",
"http://www.cs.utexas.edu/~yzhang/papers/anomography-tr05.pdf",
"http://eeweb.poly.edu/el933/papers/anomography.pdf",
"http://www.cs.utexas.edu/users/yzhang/papers/anomography-imc05.pdf",
"http://www.maths.adelaide.edu.au/matthew.roughan/Papers/imc2005.pdf",
"http://www.imconf.net/imc-2005/papers/imc05efiles/zhang/zhang.pdf",
"http://dl.acm.org/citation.cfm?id=1251116",
"http://www.cs.utexas.edu/ftp/techreports/tr05-38.pdf",
"http://www.cs.utexas.edu/~yzhang/papers/anomography-imc05.pdf"
] | [
{
"name": "Yin Zhang",
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},
{
"name": "Zihui Ge",
"ids": [
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},
{
"name": "Albert G. Greenberg",
"ids": [
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},
{
"name": "Matthew Roughan",
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}
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] | [
"Computer Science"
] | 2,005 | IMC '05 | 317-330 | [
"DBLP"
] | 10.1145/1330107.1330146 | https://doi.org/10.1145/1330107.1330146 | 2293322640 |
||||
f62415be3ff1cc95ee10cd7236cd3b11d29165e0 | Wild Western Lowland Gorillas Signal Selectively Using Odor | Mammals communicate socially through visual, auditory and chemical signals. The chemical sense is the oldest sense and is shared by all organisms including bacteria. Despite mounting evidence for social chemo-signaling in humans, the extent to which it modulates behavior is debated and can benefit from comparative models of closely related hominoids. The use of odor cues in wild ape social communication has been only rarely explored. Apart from one study on wild chimpanzee sniffing, our understanding is limited to anecdotes. We present the first study of wild gorilla chemo-communication and the first analysis of olfactory signaling in relation to arousal levels and odor strength in wild apes. If gorilla scent is used as a signaling mechanism instead of only a sign of arousal or stress, odor emission should be context specific and capable of variation as a function of the relationships between the emitter and perceiver(s). Measured through a human pungency scale, we determined the factors that predicted extreme levels of silverback odor for one wild western lowland gorilla (Gorilla gorilla gorilla) group silverback. Extreme silverback odor was predicted by the presence and intensity of inter-unit interactions, silverback anger, distress and long-calling auditory rates, and the absence of close proximity between the silverback and mother of the youngest infant. Odor strength also varied according to the focal silverback's strategic responses during high intensity inter-unit interactions. Silverbacks appear to use odor as a modifiable form of communication; where odor acts as a highly flexible, context dependent signaling mechanism to group members and extra-group units. The importance of olfaction to ape social communication may be especially pertinent in Central African forests where limited visibility may necessitate increased reliance on other senses. | [] | https://semanticscholar.org/paper/f62415be3ff1cc95ee10cd7236cd3b11d29165e0 | [
"http://dspace.stir.ac.uk/bitstream/1893/20869/1/journal%20pone%200099554%20(1).pdf",
"http://ftp.ncbi.nlm.nih.gov/pub/pmc/d5/06/pone.0099554.PMC4090154.pdf",
"http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0099554&type=printable"
] | [
{
"name": "Michelle Klailova",
"ids": [
"4641946"
]
},
{
"name": "Phyllis C. Lee",
"ids": [
"34728327"
]
}
] | [
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] | [
"Biology",
"Medicine"
] | 2,014 | PloS one | PLoS ONE | 9 | [
"Medline"
] | 10.1371/journal.pone.0099554 | https://doi.org/10.1371/journal.pone.0099554 | 25006973 | 2034570620 |
||
82fc563ad7379926b697238f153ca71499d9745f | New method for the determination of adsorption space volume for sorbents with an arbitrary porous structure from excess gas adsorption isotherm measurements | A new method for the determination of adsorption space volume has been proposed, which is applicable to adsorbents with an arbitrary porous structure, including nonporous adsorbents with open surfaces. The method is based on the use of an experimental excess adsorption isotherm measured over a wide range of pressures in the equilibrium gaseous phase (as a rule up to 100–150 MPa) and the absolute adsorption isotherm equation with unspecified parameters in the most general form, given by statistical physics. The method has been tested for a number of adsorption systems, and it has been found that the result was always unambiguous, correct, and stable in the sense of input data. | [] | https://semanticscholar.org/paper/82fc563ad7379926b697238f153ca71499d9745f | [] | [
{
"name": "T. S. Yakubov",
"ids": [
"92230012"
]
},
{
"name": "L. G. Shekhovtsova",
"ids": [
"91122244"
]
},
{
"name": "A. A. Pribylov",
"ids": [
"91155108"
]
}
] | [
"9cd050aca6f914fe6aa6c48f80f126557d25de92",
"35abd86dcecead3cabe7de64fcf1dce38a40fdac"
] | [
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"2312c788991034b0b248cf3be4507dd01a77f1df"
] | [
"Chemistry"
] | 1,995 | Russian Chemical Bulletin | 44 | 2277-2281 | [] | 10.1007/BF00713593 | https://doi.org/10.1007/BF00713593 | 2093370634 |
|||
79f9ff0d6837460777a8a639264b21f3fd117904 | Female sexual dysfunction | I was very happy to see a nonmedical opinion piece about what seems to be a nonmedical problem, at least in older adults (those more than, say, 50 years old).[1][1] I have been in clinical practice for nearly 40 years, and the only women I can recall who complained of decreased sexual desire after | [] | https://semanticscholar.org/paper/79f9ff0d6837460777a8a639264b21f3fd117904 | [] | [
{
"name": "Duncan S Armstrong",
"ids": [
"153302109"
]
}
] | [] | [
"2b543e2c09914919ea7157cf349d34f7f62330a5"
] | [
"Medicine"
] | 2,015 | Canadian Medical Association Journal | Canadian Medical Association Journal | 187 | 1312 - 1312 | [
"Medline"
] | 10.1503/cmaj.1150072 | https://doi.org/10.1503/cmaj.1150072 | 26574003 | 2410694476 |
|
7ffb0bca48e73c08ce746dd0324e3932752831ea | Path-Oriented Control/Display Augmentation for Perspective Flight-Path Displays | Flight-path predictor display augmentation and flight-path vector control augmentation concepts have been developed to improve pilot performance and reduce workload with a perspective flight-path display. A recent comparison study conducted at the Delft University of Technology showed a preference for control augmentation, although some improvements could still be made. Pilots command the direction of the aircraft motion and, because in curved trajectories the direction must constantly change, they are required to hold the stick deflected during turns. It is also not clear how much stick deflection is needed during a particular turn. This paper discusses an augmentation concept that addresses these issues. A path-oriented control and display augmentation is described in which the pilot commands the curvature of the aircraft future trajectory, shown as a perspective wireframe on the display. Results of an experiment, conducted in a fixed-base simulator, indicate that although pilot performance improved with this path-augmentation concept, pilot workload and control activity increased. A surprising result of the path-augmentation concept was the relatively large improvement in vertical pilot performance; its primary goal was to improve lateral pilot performance. | [] | https://semanticscholar.org/paper/7ffb0bca48e73c08ce746dd0324e3932752831ea | [] | [
{
"name": "Clark Borst",
"ids": [
"1981714"
]
},
{
"name": "Max Mulder",
"ids": [
"144151178"
]
},
{
"name": "M. M. van Paassen",
"ids": [
"70107107"
]
},
{
"name": "Jan Albert Mulder",
"ids": [
"143614565"
]
}
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] | [
"Engineering"
] | 2,006 | Journal of Guidance Control and Dynamics | 29 | 780-791 | [] | 10.2514/1.16469 | https://doi.org/10.2514/1.16469 | 2095064410 |
|||
227f480dfb141daa4c1fa44cdc2deea518fb8082 | Logistické požadavky na obaly | The thesis devotes to 1st class handling packaging. It studies the analysis of the most frequent used packaging materials and packaging containers made out of them. The work also describes the main requirements every packaging must fulfil. A new packaging design procedure is described in the end of the work. | [] | https://semanticscholar.org/paper/227f480dfb141daa4c1fa44cdc2deea518fb8082 | [] | [
{
"name": "Milan Fiala",
"ids": [
"46800364"
]
}
] | [] | [] | [
"Engineering"
] | 2,008 | [] | 2277491452 |
||||||||
510cba1974bbd75b886478f7981b4dfedd632a03 | Quality of life among Iranian beta-thalassemia major patients in southern coastwise of the Caspian Sea | Background and Objectives: Beta-thalassemia major (TM), a chronic, genetically determined haematological disorder, has received little investigation on the quality of life and psychological aspects of the disease. The aim of this study was to explore the nature of quality of life, psychological aspects and life satisfaction in TM patients. Materials and Methods: A Cross-section descriptive study was conducted at the 16 TM Units of different hospitals of Mazandaran province, Iran in 2008. Quality of life, psychological aspects and life satisfaction were evaluated by the four questionnaires including; demographic characteristics, the Short Form 36 health survey (SF-36), Persian version of Symptoms Checklist-90-Revised (SCL-90-R), Life Satisfaction Index (LSI). Results: 687 (41.08%) of the 1672 eligible patients with TM completed the questionnaires. The mean age of the participations was 21.93±5.90 years and with a range of 15-45 years. 52.8% (n = 363) were female, and mostly were single (68.7%). The physical functioning index has the highest mean score (73.58 ±21.89) and vitality has the lowest mean score (52.79 ±12.73) of eight indexes of SF-36. (n = 446, 64.9%) of TM patients had Global Severity Index (GSI) > 0.7 as psychiatric patients, (n = 141, 20.5%) had GSI between 0.4 and 0.7 as suspected psychiatric patients, and (n = 100, 14.6%) had GSI < 0.4 as non-psychiatric patients. The mean scores of LSI questionnaire was 20.50±5.95 and with a range of 2 to 37. Conclusion: These findings show that TM patients are at risk for low to middle quality of life and life satisfaction, and psychiatric symptomatology and need appropriated psychiatric consults for improvement of their quality of life. | [] | https://semanticscholar.org/paper/510cba1974bbd75b886478f7981b4dfedd632a03 | [
"https://journals.bmsu.ac.ir/jbs/index.php/jbs/article/download/153/84"
] | [
{
"name": "حسن خانی",
"ids": [
"66964590"
]
},
{
"name": "آمنه قربانی",
"ids": [
"83569924"
]
},
{
"name": "حمید طیبی فرد",
"ids": [
"78209447"
]
},
{
"name": "میثم رمضانی",
"ids": [
"84094337"
]
},
{
"name": "محدثه بیدارمغزی",
"ids": [
"77798572"
]
},
{
"name": "مسعود مظفر جلالی",
"ids": [
"82530538"
]
},
{
"name": "مجتبی خضری",
"ids": [
"83683949"
]
}
] | [] | [
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] | [
"Medicine"
] | 2,013 | 1 | [] | 1444244184 |
|||||||
4a0fbda04f4eb6f39fb44dc8b4f03dd665ec0562 | Utility of a single beta HCG measurement to evaluate for absence of ectopic pregnancy. | The objectives of this study were to determine the optimal cutoff value (CV) and utility of a single serum beta human chorionic gonadotropin hormone (HCG) level in assessing the likelihood of ectopic pregnancy (ECP). A retrospective chart review was performed at an urban county hospital. The optimal CV was determined by comparing all available patients diagnosed with ECP and patients diagnosed with threatened abortion (TA) in the Emergency Department (ED) who subsequently delivered a baby at the same hospital. The utility of the test was assessed in a group of all known patients who presented to the ED with lower abdominal or pelvic pain or vaginal bleeding between 6 and 13 weeks estimated gestational age (EGA). There were 212 ECPs with measured HCGs. Only nine presented after 13 weeks EGA. The mean HCG value was 5,378 mIU/mL. There was no significant correlation between HCG and EGA. There were 132 TAs with measured HCGs who subsequently delivered. Only four TAs presented before 6 weeks EGA. Regarding the TA patients who presented between 6 and 13 weeks EGA, there were 81 with a mean HCG of 83,810 mIU/mL. Between 6 and 13 weeks EGA, HCG was not significantly correlated with EGA. The entire ECP group was compared with the TA group with 6-13 week EGA. A receiver-operating characteristic curve with nine HCG cutoff values was constructed. Clinically, the optimal CV was 40K. At this level, a test for the condition "absence of ECP" had a specificity of 99%, and only two of 212 ECPs in our group would test false-positive with an HCG value over 40K. When the test was applied to a group of 175 women who presented with pain or bleeding between 6 and 13 weeks EGA, the sensitivity and positive predictive value for an intrauterine pregnancy were 24% and 99.9 %, respectively. However, if this test was applied to all patients regardless of clinical findings, and then an ultrasound (U/S) algorithm was applied to the patients who had an HCG of less than 40K, it would predictably increase the rate of ECPs falsely identified as intrauterine pregnancies (IUPs) by 1%, regardless of the false-positive rate of the U/S algorithm itself. Given the potential morbidity and mortality of undiagnosed ectopic pregnancy, ultimately neither this test nor any other that is less than 100% specific for IUP can be recommended instead of an initial U/S evaluation for patients who present at risk for ECP. | [] | https://semanticscholar.org/paper/4a0fbda04f4eb6f39fb44dc8b4f03dd665ec0562 | [] | [
{
"name": "K A Marill",
"ids": [
"3877434"
]
},
{
"name": "T E Ingmire",
"ids": [
"16172272"
]
},
{
"name": "B K Nelson",
"ids": [
"47140144"
]
}
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] | [
"Medicine"
] | 1,999 | The Journal of emergency medicine | The Journal of emergency medicine | 17 3 |
419-26
| [
"Medline"
] | 10.1016/S0736-4679(99)00007-4 | https://doi.org/10.1016/S0736-4679%2899%2900007-4 | 10338231 | 2084351584 |
|
2028b0f210a389d9d0918a28cae9ae9c6a6233a4 | Genomic Reduction at TTC Repeats in the Bacterial Genome of Treated Cases of Hansen's Disease: A Possible Survival Mechanism of Mycobacterium leprae | Introduction: Mycobacterium leprae has a small genome and a tendency of persisting as a very low-grade infection. The authors have shown earlier, that the changes in TTC repeats, in M. leprae genome may contribute to the restriction of the pathogenicity of the bacterium and its survival strategy in case of pure neural Hansen's disease. We suspect, that a similar genomic reduction if happens in treated cases of Hansen's disease, can be a determining factor for developing persisters and relapse. Aim: The present study aimed to find out if there was any evidence of genomic reduction in treated cases of Hansen's disease that showed microbiological nonresponse. Methods: Skin biopsies were taken from treated cases of Hansen's disease at tertiary centers in Kolkata and at Raipur who had bacterial index (BI) unchanged or increased compared to their pretreatment BI. Analysis for the mutation in rpoB gene and folP1 gene were done to rule out rifampicin and dapsone resistance, respectively. The entire TTC repeat region of the bacteria was amplified by polymerase chain reaction and was subjected to sequencing. The obtained sequences were then analyzed by CLUSTALW. Results: A total of 127 patients were included in the study of which in 52 the BI remained same and 75 had an increase in BI, even after 6 months of completion of multidrug therapy. Among the samples, 2 had positive rpoB gene mutation. No mutation was found in the folP1 gene. The TTC repeat of both the rpoB-resistant samples was found to have 17 copies, which matched their pretreatment copy number. In other 125 cases, 60 cases showed no change from their pretreatment TTC number. Of those 65 samples that showed evidence of genomic reduction, 11 samples showed one copy, 41 showed 2 copies, and 13 showed 3 copies deletion. We also observed a significant regional variation. Conclusion: We concluded that there was evidence of genomic reduction, which might lead to microbiological nonresponse in treated cases of Hansen's disease. This indicated a possibility of future persistence and relapse. | [] | https://semanticscholar.org/paper/2028b0f210a389d9d0918a28cae9ae9c6a6233a4 | [] | [
{
"name": "Abu Hena Hasanoor Reja",
"ids": [
"39925750"
]
},
{
"name": "Abhishek De",
"ids": [
"48204167"
]
},
{
"name": "Pradip Kumar Patra",
"ids": [
"48905568"
]
},
{
"name": "Supratik Biswas",
"ids": [
"6706692"
]
},
{
"name": "Umesh Duttagupta",
"ids": [
"52094611"
]
},
{
"name": "Amrita Sil",
"ids": [
"1953361"
]
},
{
"name": "Nibir Biswas",
"ids": [
"47078135"
]
},
{
"name": "Surajita Bannerjee",
"ids": [
"52113522"
]
},
{
"name": "Aarti Sarda",
"ids": [
"91501560"
]
},
{
"name": "Basudev Bhattacharya",
"ids": [
"40171859"
]
}
] | [
"f0c7460f41ee3e16597358e9f700b9c8288ec7df"
] | [
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] | [
"Medicine"
] | 2,018 | Indian journal of dermatology | Indian Journal of Dermatology | 63 | 449 - 454 | [
"Medline"
] | 10.4103/ijd.IJD_90_18 | https://doi.org/10.4103/ijd.IJD_90_18 | 30504970 | 2903786064 |
|
57b9cd4c159412b588cda5685cd310896b360a07 | On a certain algebra associated with a polarized algebraic variety | In the present note we associate a certain algebra of finite rank over Q to each non-singular polarized algebraic variety defined over C . For a surface the algebra is a Jordan algebra with identity, and for an abelian variety A the algebra is canonically isomorphic to the Jordan algebra of symmetric elements in End Q (A) with respect to the involution induced by the polarization. This algebra may be important for a polarized algebraic variety as much as End Q (A) for an abelian variety A . | [] | https://semanticscholar.org/paper/57b9cd4c159412b588cda5685cd310896b360a07 | [] | [
{
"name": "Hisasi Morikawa",
"ids": [
"101841839"
]
}
] | [
"bee529bae52c999c45181c9c3248a22dbeae0129"
] | [] | [
"Mathematics"
] | 1,974 | Nagoya Mathematical Journal | 53 | 109-113 | [] | 10.1017/S0027763000016068 | https://doi.org/10.1017/S0027763000016068 | 1596392028 |
|||
3e4da59b373650576e5a9c82d5c42559c045c4df | Entreprenurial Human Capital and Inward Technology Licensing in the Context of New Technology-Based Firms | This study investigates the rate of using ITL, specifically relating to the human capital (HC) of NTBFs: (1) Does HC of entrepreneurs have an influence on the ITL? (2) If so, then to what extent does specific HC and general HC demonstrate a different effect? Using a subset of 649 considerable NTBF’s, created from the seventh follow-up of the Kauffman Firm Survey longitudinal data, the study found that different HC within NTBFs may explain the rate of using external technologies, which answers the first question. The findings reinforce existing understandings of HTC, which concern the effect of HC on entrepreneurial activities such as opportunity search. In regards to the second research question, the found that level of general education and industry-specific startup experience are positively related to the rate of ITL. A major contribution of this study is that it presented evidence to support applicability of current insights of a specific innovation strategy, ITL, in the context of NTBFs. | [] | https://semanticscholar.org/paper/3e4da59b373650576e5a9c82d5c42559c045c4df | [] | [
{
"name": "Yongseok Jang",
"ids": [
"47083451"
]
}
] | [] | [
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] | [
"Business"
] | 2,019 | International Journal of Innovation and Technology Management | 16 | 1950053 | [] | 10.1142/s0219877019500536 | https://doi.org/10.1142/s0219877019500536 | 2981338100 |
|||
3c1cc2601e94340e8d693be87f2b92d056f0c317 | Bayesian hidden Markov model for DNA sequence segmentation: A prior sensitivity analysis | The sensitivity to the specification of the prior in a hidden Markov model describing homogeneous segments of DNA sequences is considered. An intron from the chimpanzee @a-fetoprotein gene, which plays an important role in embryonic development in mammals, is analysed. Three main aims are considered: (i) to assess the sensitivity to prior specification in Bayesian hidden Markov models for DNA sequence segmentation; (ii) to examine the impact of replacing the standard Dirichlet prior with a mixture Dirichlet prior; and (iii) to propose and illustrate a more comprehensive approach to sensitivity analysis, using importance sampling. It is obtained that (i) the posterior estimates obtained under a Bayesian hidden Markov model are indeed sensitive to the specification of the prior distributions; (ii) compared with the standard Dirichlet prior, the mixture Dirichlet prior is more flexible, less sensitive to the choice of hyperparameters and less constraining in the analysis, thus improving posterior estimates; and (iii) importance sampling was computationally feasible, fast and effective in allowing a richer sensitivity analysis. | [] | https://semanticscholar.org/paper/3c1cc2601e94340e8d693be87f2b92d056f0c317 | [
"http://hal.archives-ouvertes.fr/docs/00/32/81/81/PDF/intron_CSDA_edited.pdf",
"https://www.wikidata.org/entity/Q56994558",
"https://hal.archives-ouvertes.fr/file/index/docid/328181/filename/intron_CSDA_edited.pdf"
] | [
{
"name": "Darfiana Nur",
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]
},
{
"name": "David Allingham",
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]
},
{
"name": "Judith Rousseau",
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]
},
{
"name": "Kerrie L. Mengersen",
"ids": [
"3069617"
]
},
{
"name": "Ross McVinish",
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]
}
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] | [
"Computer Science"
] | 2,009 | Comput. Stat. Data Anal. | Comput. Stat. Data Anal. | 53 | 1873-1882 | [
"DBLP"
] | 10.1016/j.csda.2008.07.007 | https://doi.org/10.1016/j.csda.2008.07.007 | 2015373627 |
||
a856b6a79a7cf00fc4271c0907f233d3e6d10248 | Difficulties for enjoyment of public spaces by residents: Maldonado-Punta del Este conurbation | Purpose
The purpose of this paper is to determine whether the various types of negative impacts have an effect on the general attitude toward tourism and the difficulty for the enjoyment of public spaces.
Design/methodology/approach
It is a quantitative study that analyzes the causal relationships between variables through structural equation models. This study uses data from a sample of 420 residents from Maldonado and Punta del Este.
Findings
The result obtained shows that only the cultural loss is significant to explain the residents’ attitudes. On the other hand, the cultural loss, the environmental deterioration and the saturation are significant to explain the difficulties for the enjoyment of public spaces.
Research limitations/implications
The main limitations are the fact of performing the analysis in a specific destination with peculiarities that may affect the results and the representativeness of the sample used.
Practical implications
The enjoyment of public spaces is a good indicator of the perception of negative impacts, so managers of urban tourist destinations can use this element as an indicator of quick consultation on residents’ attitudes.
Originality/value
It is a study that focuses on the negative impacts of tourism and its effect on the public spaces. The importance of public spaces in tourist destinations is under studied. | [] | https://semanticscholar.org/paper/a856b6a79a7cf00fc4271c0907f233d3e6d10248 | [] | [
{
"name": "María Dolores Sánchez-Fernández",
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},
{
"name": "Daniel Álvarez-Bassi",
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},
{
"name": "José Ramón Cardona",
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]
}
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] | [
"Sociology"
] | 2,018 | 4 | 391-407 | [] | 10.1108/IJTC-11-2017-0069 | https://doi.org/10.1108/IJTC-11-2017-0069 | 2800320488 |
||||
7a5b131de1ebdeddfaa1d210d6a39fa2013bec44 | The influence of Aclacinomycin A on the immune response and on experimental immune disorders. | The anti-cancer drug Aclacinomycin A (ACM) was able to inhibit the humoral immune response of mice against sheep red blood cells. This could be demonstrated in the formation of antibody secreting cells (PFC) and serum antibody titers, when ACM was administered either together with the antigen or three days after antigen application. Cellular immunity was not affected by the drug. In two murine Graft-vs-Host (GvH) disease models leading to two different B cell dependent auto-immune diseases (immune complex glomerulonephritis and immune hemolytic anemia) a protective effect of ACM was observed when it was administered at the time of the graft. The application of ACM in the induction phase mitigated the development of glomerulonephritis and prevented animals from dying due to hemolytic anemia. Only a slight therapeutical effect was observed when ACM was given after the appearance of clinical symptoms. In a T cell induced auto-immune disease (experimental allergic encephalomyelitis (EAE], ACM had no discernible effect on the course of the disease. It seems that the therapeutic effects of ACM on GvH-diseases are mediated via suppression of B-lymphocytes. | [] | https://semanticscholar.org/paper/7a5b131de1ebdeddfaa1d210d6a39fa2013bec44 | [] | [
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},
{
"name": "H H Sedlacek",
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"Medicine"
] | 1,984 | International journal of immunopharmacology | International journal of immunopharmacology | 6 4 |
307-13
| [
"Medline"
] | 10.1016/0192-0561(84)90047-X | https://doi.org/10.1016/0192-0561%2884%2990047-X | 6332788 | 1999186968 |
|
bdd095a7ca944f02542bc51d1c21d3391ed3e430 | How architectural education in Sweden supports the role of handling the user involvement in the building process | How architectural education in Sweden supports the role of handling the user involvement in the building process | [] | https://semanticscholar.org/paper/bdd095a7ca944f02542bc51d1c21d3391ed3e430 | [
"http://www.irbnet.de/daten/iconda/CIB5583.pdf"
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{
"name": "Ingrid Svetoft",
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"Engineering"
] | 2,005 | 459-466 | [] | 600258164 |
|||||||
0b64ef97e8cbd46adf0f504b3f822850b213ff8b | The Detection of Serum MMP-3 in Cerebral Infarction | Objective: To investigate the role and clinical significance of serum MMP-3 in cerebral infarction. Methods: Serum MMP-3 levels were measured in 59 cerebral infarction patients (during 24 h～15 days of the onset) and 32 healthy people by ELISA. Results: The level of MMP-3 during 24 h～5 days of the cerebral infarction is higher than those of control ( P 0 05). No obvious relationship were observed between the levels of MMP-3 and the fast blood sugar (FBS),total serum cholesterol,and serum glycerol. Conclusion : MMP-3 may contribute the pathologic course in the early stage of cerebral infarction,and the level of MM P-3 is correlated with the clinical course of the disease. | [] | https://semanticscholar.org/paper/0b64ef97e8cbd46adf0f504b3f822850b213ff8b | [] | [
{
"name": "Xiao Xiao-hua",
"ids": [
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]
}
] | [] | [] | [
"Medicine"
] | 2,004 | [] | 2368225722 |
||||||||
f623e8ff063e0c90cd6ff2b3718d4b0ec8e05af7 | Internalize at your peril: internalizing disorders as risk factors for dementia-cohort study. | Few studies examined comorbid anxiety and depression's independent association with dementia. We assessed internalizing disorders as risk factors for dementia to avoid pitfalls inherent in separating anxiety and depression. Retrospectively designed prospective comparative cohort study using New Zealand's (NZ) National Minimum Dataset of hospital discharges. Hazards ratios (HRs), estimated from parametric survival models, compared the time to incident dementia after a minimal latency interval of 10 years between those with and without prior diagnosis of an internalizing disorder. A total of 47,932 patients aged 50-54 years were discharged from a publicly funded hospital events in NZ between 1988 and 1992. Of these, 37,631 (79%) met eligibility criteria, and incident dementia was diagnosed in 1594. Rates of incident dementia were higher among patients with an earlier diagnosis of internalizing disorders (572 vs 303 per 100,000 person years at risk (PYAR)). After adjustment for age, sex, ethnicity, and region, those with internalizing disorders were estimated to have a higher risk of developing dementia than those without (adjusted HR = 1.57, 95% CI 1.17-2.10). Females with an earlier diagnosis of internalizing disorders were estimated to have almost twice the risk of developing dementia (adjusted HR 1.80, 95% CI 1.25-2.59). Internalizing disorders affect one in five adults globally. Our findings suggest a significant increase in risk of dementia more than 10 years after the diagnosis of internalizing disorder. | [] | https://semanticscholar.org/paper/f623e8ff063e0c90cd6ff2b3718d4b0ec8e05af7 | [] | [
{
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{
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},
{
"name": "Diana Paleacu",
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}
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"Medicine"
] | 2,020 | GeroScience | GeroScience | [
"Medline"
] | 10.1007/s11357-020-00285-y | https://doi.org/10.1007/s11357-020-00285-y | 33067707 | 3093105177 |
|||
90f94c170fde8b759ff001ad5d44254521dc984c | Incorporating prior information into differential network analysis using non‐paranormal graphical models | Motivation: Understanding how gene regulatory networks change under different cellular states is important for revealing insights into network dynamics. Gaussian graphical models, which assume that the data follow a joint normal distribution, have been used recently to infer differential networks. However, the distributions of the omics data are non‐normal in general. Furthermore, although much biological knowledge (or prior information) has been accumulated, most existing methods ignore the valuable prior information. Therefore, new statistical methods are needed to relax the normality assumption and make full use of prior information. Results: We propose a new differential network analysis method to address the above challenges. Instead of using Gaussian graphical models, we employ a non‐paranormal graphical model that can relax the normality assumption. We develop a principled model to take into account the following prior information: (i) a differential edge less likely exists between two genes that do not participate together in the same pathway; (ii) changes in the networks are driven by certain regulator genes that are perturbed across different cellular states and (iii) the differential networks estimated from multi‐view gene expression data likely share common structures. Simulation studies demonstrate that our method outperforms other graphical model‐based algorithms. We apply our method to identify the differential networks between platinum‐sensitive and platinum‐resistant ovarian tumors, and the differential networks between the proneural and mesenchymal subtypes of glioblastoma. Hub nodes in the estimated differential networks rediscover known cancer‐related regulator genes and contain interesting predictions. Availability and Implementation: The source code is at https://github.com/Zhangxf‐ccnu/pDNA Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics online. | [] | https://semanticscholar.org/paper/90f94c170fde8b759ff001ad5d44254521dc984c | [
"https://www.wikidata.org/entity/Q38838330"
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{
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},
{
"name": "Hong Yan",
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}
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"4cc977570ae652233038d2d51559fe50863c720f",
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"3fc17a36e2bec28396fd17c1ec2288d817564565",
"c71628acf8a09adf00912fece71908e49a1be842"
] | [
"Computer Science",
"Medicine"
] | 2,017 | Bioinform. | Bioinformatics | 33 | 2436–2445 | [
"Medline",
"DBLP"
] | 10.1093/bioinformatics/btx208 | https://doi.org/10.1093/bioinformatics%2Fbtx208 | 28407042 | 2607356028 |
|
ad576d7bb254732f4ad194c8f33149d4b2e6edd2 | Правовое регулирование расчетов за перевозку груза в прямом смешанном сообщении | Object: Russian legislation regulates the multimodal transportation’s (mixed traffic’s) accounts with two co-carriers only. There is no legal execution of the multimodal transportation’s (mixed traffic’s) accounts with three or more co-carriers. So that, this article is devoted to the problems of legal regulation of the multimodal transportation’s (mixed traffic’s) accounts. Model: our research is founded on the analysis of normative legal acts, which are regulating this kind of carriage of goods. There is compared operable order of studied accounts with order, which is offered in official project of Federal statute “About multimodal (combined) transportation”. In this article are also examined changes of transportation tariffs and their influence on the multimodal transportation’s (mixed traffic’s) accounts. Deductions: there is offered order of the multimodal transportation’s (mixed traffic’s) accounts in this article. There also are offered the wording of the norms which are regulating the order of multimodal transportation’s (mixed traffic’s) accounts and establish the consignor’s and consignee’s liability for breaching of the contract. Value: as the result of this research is the offered order of multimodal transportation’s (mixed traffic’s) accounts, which isn’t depending upon the number of co-carriers. This order may be used in preparation of the official project of Federal statute “About multimodal (combined) transportation”, which should be adopted according to the article N 788 of the Civil Code of the Russian Federation. | [] | https://semanticscholar.org/paper/ad576d7bb254732f4ad194c8f33149d4b2e6edd2 | [] | [
{
"name": "В. Н. Гречуха",
"ids": [
"119799479"
]
},
{
"name": "О. К. Какорина",
"ids": [
"120705041"
]
}
] | [] | [] | [
"Political Science"
] | 2,014 | [] | 2572625151 |
||||||||
1d7ef4aaafa4482095bbfb0ede503a0c57b96b52 | PROJECT BASED ACTIVITIES IN A CALL CLASSROOM: EFL STUDENTS’ EXPERIENCES | This study investigates students’ perspectives and measured their attitude, confidence, and anxiety when interacting with omputer Assisted Language Learning (CALL) through project-based instructions. Thirty students from a CALL course participated in this study by responding to a questionnaire and writing a reflective note about their experiences in the course. The qualitative research findings indicate that the majority of the students possess a ositive attitude, confidence and anxiety levels towards the use of technology in their course even though the statistical analysis indicated that there were no significant differences of the students’ attitudes, confidence, and anxiety levels before and after taking the CALL course. Considering the findings, the researchers suggest hat the technology-based projects discussed in the present study can become viable learning activities to prepare pre-service EFL teachers to deal with the effort and initiative by the Ministry of Education in some countries to encourage local teachers integrating the best and wisest use of technology into lessons. Pedagogical implications for teaching and learning CALL as well as direction for further research are discussed in the study. | [] | https://semanticscholar.org/paper/1d7ef4aaafa4482095bbfb0ede503a0c57b96b52 | [
"https://ejournal.upi.edu/index.php/ije/article/download/10177/pdf",
"http://ejournal.upi.edu/index.php/ije/article/download/10177/pdf_1"
] | [
{
"name": "Yustinus Calvin Gai Mali",
"ids": [
"72162104"
]
},
{
"name": "Anne Indrayanti Timotius",
"ids": [
"118442665"
]
}
] | [] | [
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"67c9a3d6e88ea616dadc663552c1f71033aa8b1c",
"abf9e6d4d76f67b02d3bebd911ab62f9d98ebf26",
"cee6c4973596fb320af3d871bf1920c8bc376adc",
"13c1e0da27b0f16c2a65d6a67517d89c6f68464f",
"66cd36d665dcc07dd2df63569f7b043dda60b2d1",
"720223a2ebf8adb97282a269c9d1891b2c2b332b",
"6b845372eed8c3c56c6be6a26b9b5eef5fa0244e",
"86ecb8f629621f9518844c2617a827a6395b5504"
] | [
"Psychology"
] | 2,018 | International Journal of Education | 11 | 6-17 | [] | 10.17509/ije.v11i1.10177 | https://doi.org/10.17509/ije.v11i1.10177 | 2899925295 |
|||
7b83de258431dcee0137fa6524c26a06d3d3a56b | Aligning Incentives at Systemically Important Financial Institutions | UBS recently announced it would pay part of the bonuses of 6,500 highly compensated employees with bonds that would be forfeited if the bank does not meet its capital requirements. This memo underscores the benefits of contingent deferred compensation and makes recommendations for how such compensation should be structured at systemically important institutions. We also revise our proposal for contingent convertible bonds, explaining how these hybrid bonds can be combined with better designs for deferred compensation to reduce the need for future bailouts. | [] | https://semanticscholar.org/paper/7b83de258431dcee0137fa6524c26a06d3d3a56b | [
"http://squamlakegroup.org/Squam%20Lake%20Bonus%20Bonds%20Memo%20Mar%2019%202013.pdf"
] | [
{
"name": "Martin Neil Baily",
"ids": [
"1406560195"
]
},
{
"name": "John Y. Campbell",
"ids": [
"1801034"
]
},
{
"name": "John Y. Campbell",
"ids": [
"1801034"
]
},
{
"name": "John H. Cochrane",
"ids": [
"47805258"
]
},
{
"name": "John H. Cochrane",
"ids": [
"47805258"
]
},
{
"name": "John H. Cochrane",
"ids": [
"47805258"
]
},
{
"name": "Douglas W. Diamond",
"ids": [
"46211779"
]
},
{
"name": "Douglas W. Diamond",
"ids": [
"46211779"
]
},
{
"name": "Darrell Duffie",
"ids": [
"1999657513"
]
},
{
"name": "Darrell Duffie",
"ids": [
"1999657513"
]
},
{
"name": "Kenneth R. French",
"ids": [
"72891652"
]
},
{
"name": "Kenneth R. French",
"ids": [
"72891652"
]
},
{
"name": "Anil K. Kashyap",
"ids": [
"47347822"
]
},
{
"name": "Anil K. Kashyap",
"ids": [
"47347822"
]
},
{
"name": "Anil K. Kashyap",
"ids": [
"47347822"
]
},
{
"name": "Frederic S. Mishkin",
"ids": [
"1383102595"
]
},
{
"name": "Frederic S. Mishkin",
"ids": [
"1383102595"
]
},
{
"name": "David S. Scharfstein",
"ids": [
"51955506"
]
},
{
"name": "David S. Scharfstein",
"ids": [
"51955506"
]
},
{
"name": "Robert J. Shiller",
"ids": [
"5736726"
]
},
{
"name": "Robert J. Shiller",
"ids": [
"5736726"
]
},
{
"name": "Robert J. Shiller",
"ids": [
"5736726"
]
},
{
"name": "Matthew J. Slaughter",
"ids": [
"17101063"
]
},
{
"name": "Matthew J. Slaughter",
"ids": [
"17101063"
]
},
{
"name": "Hyun Song Shin",
"ids": [
"101003343"
]
},
{
"name": "René M. Stulz",
"ids": [
"119210342"
]
},
{
"name": "René M. Stulz",
"ids": [
"119210342"
]
}
] | [
"dd3342693551966b928afc7f63fc55e372e26674",
"43d924e4be267555eac46df2e52e18eaf5c54d5f",
"7dccf2905883276587a300e542cf34c5a455a93a",
"7f6428c10e46ad5968c1e8f95107c9c8fb745262",
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"e847e1464860316291f9beadcb315b3246cc29a7",
"b0767d86f6d796474c920dbaf734cde3083ec6b4"
] | [] | [
"Business"
] | 2,013 | [] | 10.2139/SSRN.2239895 | https://doi.org/10.2139/SSRN.2239895 | 2734584228 |
||||||
7630b4f5f39c4060f3a672d10d623a5bcc02e46b | AN EFFICIENT STATIC TOPOLOGY FOR MODELING ASOCS | ASOCS (Adaptive Self-Organizing Concurrent Systems) are a class of connectionist computational models which feature self-organized learn-ing and parallel execution. One area of ASOCS research is the development of an efficient implementation of ASOCS using current technology. A result of this research is the Location-Independent ASOCS model (LIA). LIA uses a parallel, asynchronous network of in-dependent nodes, which leads to an efficient physical realization using current technology. This paper reviews the behavior of the LIA model, and shows how a static binary tree topology efficiently supports that behavior. The binary tree topology allows for O(log(n)) learning and execution times, where n is the number of nodes in the network. | [] | https://semanticscholar.org/paper/7630b4f5f39c4060f3a672d10d623a5bcc02e46b | [
"ftp://axon.cs.byu.edu/pub/papers/rudolph_91a.ps"
] | [
{
"name": "George L. Rudolph",
"ids": [
"1985027"
]
},
{
"name": "Tony R. Martinez",
"ids": [
"90716724"
]
}
] | [
"bae08fe2873e0fa29d0d150865d45618dea05fc8",
"3e847c0848caf085c1d28a2024c9b81b18714838",
"e366b8302e963b55d5c07be61933bae7e6b9ddd2",
"1d4c5769f8af8df66c7813d518cc7c5e6bedda51",
"7cd5c81742cac92b0881e68402cc20d585fea028",
"f870588c8b25e0d8d1f7ce10b931e82fa33d058c",
"d0d9d71261ec05fd42805c38545c3711432b1fed",
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"916284752a3b3bf1e22296d392eb3b2c2947249b",
"27c8ac794fe47f3f83227b6915eee5f44bd60edf"
] | [
"98588267ca20a27033047b640f0e872e18c36b49",
"34955f3d1ca5f8ab59c13695b764f07c9b2adf1e",
"ff2c2e3e83d1e8828695484728393c76ee07a101",
"90227a2152ba025772427822d169fa21685cd3fc",
"dbf04f727cb9261c038620bdc49121f760c109a0"
] | [
"Computer Science"
] | 1,991 | [] | 108214192 |
||||||||
71c40de4f2bf55ecf63dafdbc0a4a5f65871bd7d | THE CONVENTIONAL METHOD OF RAINWATER COLLECTION AND THE ION-EXCHANGE RESIN METHOD IN MONITORING THE NITROGEN DEPOSITION FROM THROUGH FALL | Concerns are on the rise over the impact of atmospheric nitrogen (N) deposition on forest ecosystems in the tropical and subtropical areas. This study used the conventional rainwater collection method and the ion-exchange resin (IER) method to measure through fall N deposition over time in the Picea abies forests in the Tibet Plateau. The results were compared, and their applicability in determining the atmospheric N deposition was analyzed. The results indicated a strong correlation between the IER method and the conventional method in determining the NH4-N and NO3-N content (R=0.47 and R=0.75, P<0.001). However, the NH4-N content measured with the IER method was generally lower, while the NO3-N was generally higher. The total mineral N deposition in through fall measured with both methods was about the same. Therefore, we can use the IER method instead of the conventional method for determining the total inorganic N deposition in forests at the Tibet Plateau. | [] | https://semanticscholar.org/paper/71c40de4f2bf55ecf63dafdbc0a4a5f65871bd7d | [
"http://aloki.hu/pdf/1706_1272312729.pdf"
] | [
{
"name": "G WANG",
"ids": [
"72742404"
]
}
] | [] | [
"3003af52862738eae8959f45f1fcad0056678ad3",
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"326cc370892f27e401354862efd435d762d0ee45",
"4ec3b63bf6755c18b676c924fd71fe569762ec82",
"db4d4d76b4adc6f00f7aa191c9ca3ce50e7c496b",
"80e748ebf0fa4857a75e2120149b2852a944423b",
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"cbe73bde2c9d339ebe21cf01c4477785f69dfbc6",
"9ddf2f77a9c55164294252f8491b85ec79b766e8",
"9e92dea70eb4b2180f5254e88bda0f253f73cc65",
"bb039528b0aa81f47506e73976f45eb8e974388b",
"9316d6abb88776116a2da46434784bf757edac9d",
"4ae9a981b3bb1fe6659dff1ecf6974a985d4152a",
"6f3e9bd613979b77b4127ce667f2a4ff05e30f4a",
"31a397a8b94ce19fe67fa58c023426eeb38675e5",
"b09ec931611973432a67b433081546062a1c4ed4",
"fdfb98e7dba6b5f04b9fcb518b0792fa3b6d3792",
"3e78479ddade9538f81cedb5ed419ef7b259e6bf",
"879284db19bfa71c144c697b1289a5a1ba1f6764"
] | [
"Biology"
] | 2,019 | Applied Ecology and Environmental Research | 17 | [] | 10.15666/aeer/1706_1272312729 | https://doi.org/10.15666/aeer%2F1706_1272312729 | 3015561866 |
||||
e9e5909579526025a09abadde918cf08ef68b1cd | 299 Interest of systematic screening of metabolic syndrome and high cardiovascular risk in French general healthy population | Background Cardiovascular disease is a leading cause of death in France; knowledge of the importance of risk factors is an important issue. Methods Between May 2006 and December 2008, in coordination with the regional health insurance fund of the Hauts-de-Seine area (CPAM 92), we performed a systematic screening of cardiovascular risk factors and metabolic syndrome in a population of men from 45 to 60 years old and women between 55 and 70 years old without any cardiovascular medical history. Results 50 000 questionnaires have been sent to residents of nine cities in Hauts-de-seine area. Answering selection questionnaires rate is about 22% (10764 persons). 8038 participants were enrolled in our study. 4 081 men (54 years old middle-age) and 4 227 women (62 years old middle-age) have been included. Among this population, 2000 (20%) persons have a medical history of hypertension (not well balanced for 51% of them), 1716 have an unknown hypertension. 20% of participants has a known dyslipidemia (not well balanced: 16%) and 1679 an unknown dyslipidemia (22%). 685 (8,5%) persons have a medical history of diabetes (not well balanced for 52% of them) and 218 an unknown one. Smokers represents 21% oh this population, more frequently men (28%) than women (13%). Abdominal obesity prevalence is very high representing in our study 3 100 persons (38%) and affects women (51%) more often than men (24%). Metabolic syndrome concerns 15% of the patients (17% of men, 13% of women). Sleepiness on the Epworth sleepiness scale represents 9%. After global cardiovascular risk assessment, 732 (9%) persons were classified at high risk of cardiovascular events, 2600 (33%) persons at moderate risk and 4700 (58%) at lower risk. Conclusion According to the important prevalence of patients with a high risk of cardiovascular events, our study demonstrates the interest of a systematic primary screening in a French healthy population. | [] | https://semanticscholar.org/paper/e9e5909579526025a09abadde918cf08ef68b1cd | [] | [
{
"name": "Imad Abi Nasr",
"ids": [
"14660483"
]
},
{
"name": "Alain Beauchet",
"ids": [
"4367446"
]
},
{
"name": "Hassan Sahraie",
"ids": [
"79388649"
]
},
{
"name": "Alain Bourez",
"ids": [
"8108125"
]
},
{
"name": "Cristophe Rodon",
"ids": [
"47249621"
]
},
{
"name": "Nicolas Mansencal",
"ids": [
"6739746"
]
},
{
"name": "Olivier Dubourg",
"ids": [
"4854857"
]
}
] | [] | [] | [
"Medicine"
] | 2,010 | Archives of Cardiovascular Diseases Supplements | 2 | 97 | [] | 10.1016/S1878-6480(10)70301-3 | https://doi.org/10.1016/S1878-6480%2810%2970301-3 | 1968997777 |
|||
c734923181267bf032ecad2bf3cfdf1a145b889e | Comparative Analysis Between the Calculi in Kidney of Intrarenal and Non-intrarenal Pelvis | 【Objective】To compare the feature of nephrograms,effect and condition of open surgery between calculi in the intrarenal and non-intrarenal pelvis.【Methods】Ninety-five patients with 118 renal calculi up to standard were included into this study.All patients were divided into group A(calculi in the intrarenal pelvis) and group B(calculi in the non-intrarenal pelvis).The feature of nephrograms,effect and condition of open surgery between group A and B were compared.【Results】The average size of calculi was(31.86±5.21) mm in group A and(20.35±3.64)mm in group B,the difference was significant(P0.05).The ratios of staghorn calculi and multi-calculi were 47.62% and 53.97% in group A and 12.73% and 20.00% in group B,respectively,the difference was significant(P0.01).Group A had a longer operative time[(207±31) min vs(121±30)min](P0.01),more blood loss [(173±45)ml vs(132±41)ml ](P0.01),more intraoperative renal parenchyma incision(36.51% vs 18.18%,P0.05) and injuries(25.40% vs 9.09%,P(0.05)),lower stones free rate(80.95% vs 94.55%,P0.05),and higher stones residual rate(19.05% vs(5.45)%,P 0.05).【Conclusion】It is essential to identify the calculi in the intrarenal and non-intrarenal pelvis by the nephrograms before nephrolithotomy.Careful plans,attentive dissection and skillful removal of calculi in the intrarenal pelvis are necessary to avoid the excess blood loss,intraoperative renal parenchyma incision and injuries,in order to increase the stones free rate and reduce residual rate. | [] | https://semanticscholar.org/paper/c734923181267bf032ecad2bf3cfdf1a145b889e | [] | [
{
"name": "Chen Chun-yan",
"ids": [
"50728805"
]
}
] | [] | [] | [
"Medicine"
] | 2,005 | Journal of Elinical Research | [] | 2387158397 |
|||||||
b3a23cd47f9422814e20ff29386e5aade5fb9cbb | Noise and errors analysis and influences on target coordinates evaluation | This paper presents a mathematical model of analyzing the effects which noise and tracking errors have made during measurements of a target position while determining its coordinates. Here is also presented a procedure for computing errors in measuring a target position in the space comprised by measurements as well as for computing errors in predetermined directions of aerial targets movement. This approach has en extensive application in increasing hit probability of fire control systems, in improving the quality of target tracking system testing, and in the optimization of allocating antiaircraft defense systems. | [] | https://semanticscholar.org/paper/b3a23cd47f9422814e20ff29386e5aade5fb9cbb | [] | [
{
"name": "Dragoslav Ugarak",
"ids": [
"70175879"
]
},
{
"name": "Momčilo Milinović",
"ids": [
"40203202"
]
}
] | [] | [] | [
"Computer Science"
] | 2,003 | Vojnotehnički Glasnik | 51 | 387-396 | [] | 10.5937/vojtehg0305387U | https://doi.org/10.5937/vojtehg0305387U | 2306035444 |
|||
7704d65f0abe554e5a40e59df0e1755b11f10bf7 | The Ulwazi Programme: A Case Study in Community-Focused Indigenous Knowledge Management | Prevailing ideas about knowledge management in post-apartheid South Africa have been marked by notions of redress, the recognition of previously marginalized narratives and categories such as intangible heritage and indigenous knowledge. Key to these developments has been a democratizing turn, a participatory approach to the development and management of knowledge resources. Born of changes in the broader political context and the policy environment, the Ulwazi Programme is a new South African heritage initiative that has been set up by the eThekwini Municipal Library’s Libraries and Heritage Department to preserve and disseminate indigenous knowledge of local communities in the greater Durban area. The Programme, in the form of a localized Wiki, functions as a collaborative online archive of local knowledge and histories that are collected from the community by volunteer fieldworkers and then shared via the Internet and on cell phones. This utilization of a combination of open-source and social media applications for archival and heritage purposes is unique in South Africa. The chapter presents the structure and the implementation details of this indigenous knowledge preservation system. | [] | https://semanticscholar.org/paper/7704d65f0abe554e5a40e59df0e1755b11f10bf7 | [] | [
{
"name": "Niall McNulty",
"ids": [
"31029426"
]
}
] | [
"e8ae404e0d1c84b256bd2528c247c497772b5dba"
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"185a74a1ec641db29e41e4b79f8ca03d72bdbbf6",
"99b91d0f9e34be23bf3d3093ad5e1aaff28780e5",
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"a9e2e70b3635898ab988c76f9ffc2815c811196d"
] | [
"Sociology"
] | 2,014 | 215-232 | [] | 10.1007/978-1-4899-7392-4_13 | https://doi.org/10.1007/978-1-4899-7392-4_13 | 114349589 |
|||||
c032b15b990af9a97778dc2b7ca27a34a5f1d3a5 | Analysis of the performance of a sustainable house, including consumer behaviour | Growing populations and diminishing water supplies are a major cause of concern for the future of cities around the world, including Perth. In order to support a larger population, it is necessary to decrease the amount of water and energy consumed per person.
This report analyses the performance of a Perth house designed to consume significantly less water and energy than the metropolitan average, through the introduction of sustainable technologies and efficient appliances and behaviours. By collecting and analysing data from 55 sensors in the house, it was possible to accurately quantify water and energy performance over the period of this project.
It was found that the house consumed 90-94% less scheme water than a standard Perth household, due to the alternative water sources in place, including rainwater, grey water reuse and bore water. With no hard surfaces on-site, the site recharges more water to the superficial aquifer than the bore draws. The house also consumed 38% less electricity than the Perth average, and was a net exporter of electricity (6.3kWh/day) owing to a 3kW solar PV system. A life cycle analysis showed an operational energy reduction of 111% over the business as usual approach, due to solar passive design, low-energy lighting and appliances, absence of mechanical heating or cooling, and the presence of solar hot water and PV systems.
As well as technology improvements, consumer behaviour was found to be significant in water and energy conservation. It was estimated that by being highly engaged users in terms of both energy and water, the occupants of Josh’s House would save approximately 20% on both energy and water through behavioural efforts alone. The relationship between attitudes and actual behaviours was investigated, and a new model for delivery of future behaviour change programs was proposed. | [] | https://semanticscholar.org/paper/c032b15b990af9a97778dc2b7ca27a34a5f1d3a5 | [
"http://researchrepository.murdoch.edu.au/id/eprint/23522/1/ENG460_Final_Thesis_Jamie_Stephen_31589729.pdf"
] | [
{
"name": "Jamie Stephen",
"ids": [
"144068971"
]
}
] | [] | [
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"f49c6094d83628f75e5f4b33fcab6290ca6d7c2c"
] | [
"Engineering"
] | 2,014 | [] | 1553992337 |
||||||||
7e50fb89029ed81fb0c911c237dc45eb44d0ee9a | Detecting Japanese Compound Functional Expressions using Canonical/Derivational Relation | The Japanese language has various types of functional expressions. In order to organize Japanese functional expressions with various surface forms, a lexicon of Japanese functional expressions with hierarchical organization was compiled. This paper proposes how to design the framework of identifying more than 16,000 functional expressions in Japanese texts by utilizing hierarchical organization of the lexicon. In our framework, more than 16,000 functional expressions are roughly divided into canonical / derived functional expressions. Each derived functional expression is intended to be identified by referring to the most similar occurrence of its canonical expression. In our framework, contextual occurrence information of much fewer canonical expressions are expanded into the whole forms of derived expressions, to be utilized when identifying those derived expressions. We also empirically show that the proposed method can correctly identify more than 80% of the functional / content usages only with less than 38,000 training instances of manually identified canonical expressions. | [] | https://semanticscholar.org/paper/7e50fb89029ed81fb0c911c237dc45eb44d0ee9a | [
"http://www.lrec-conf.org/proceedings/lrec2012/pdf/902_Paper.pdf"
] | [
{
"name": "Takafumi Suzuki",
"ids": [
"1799514"
]
},
{
"name": "Yusuke Abe",
"ids": [
"46705155"
]
},
{
"name": "Itsuki Toyota",
"ids": [
"2468720"
]
},
{
"name": "Takehito Utsuro",
"ids": [
"1732417"
]
},
{
"name": "Suguru Matsuyoshi",
"ids": [
"2757584"
]
},
{
"name": "Masatoshi Tsuchiya",
"ids": [
"1726728"
]
}
] | [
"535dd916ebebd7cae2c5b552fda56003555e75f4",
"85984e3a3e5d73959a52f815ffa2445df7e6c3d9",
"3a3757a79323d69426cafca802fe919d4bd5fbdf",
"97d8640c94a5ce04409afd2da4d9c354b0af0565",
"a4103ca9c9336c43ae27c590763df9c7200eafc2",
"3cd2a6b0753e1a31184e0891ca7735a3158682df"
] | [
"bee9a1bd4899fdeb371627b66714835fd7895aa0",
"5ddc4d50e13e85043412f595bf545d64ffd3186c",
"e564f53916c2fc512e72a90f1e6741ce9b99b67a",
"eed8136aa30209ffefe93bc0499943bf4d8dd5fb",
"882a2e0774dcaddacf98475c8c2ebae039487af8",
"560d58e22423d9daeaa5fcaf5764abc5436689ed",
"e9e07adaaf632f99fe275bd73104bca0705123ab",
"4a2a64158815b885c062be13b81f6849abf6e962",
"5504f4ec7b7b7b074e9dc557beeaf68c76b65540",
"8cf24826e5bbe8e9e3161bdb98c0523b3ace5443",
"156a38243cd1e0a59bb4f827b4a3850bd643f242",
"cf69b7010975cfa452e72bc66cab9bf1a598a097",
"c3874ace862608351c439a09e838e626488b2ca8"
] | [
"Computer Science"
] | 2,012 | LREC | 2012 | [
"DBLP"
] | 2251322200 |
||||||
f4549a8931f43f2e66cddba858b4600eea153a96 | Mannan‐Binding Protein Forms Complexes with α‐2‐Macroglobulin. A Proposed Model for the Interaction | We report that α‐2‐macroglobulin (α2M) can form complexes with a high molecular weight porcine mannan‐binding protein (pMBP‐28). The α2M/pMBP‐28 complexes were isolated by PEG‐precipitation and affinity chromatography on mannan‐Sepharose, protein A‐Sepharose and anti‐IgM Sepharose. The occurrence of α2M/pMBP‐28 complexes was further indicated by crossed immunoelectrophoresis and by use of an anti‐α2M affinity column and chelating Sepharose loaded with Zn2+. The eluates from these affinity columns showed α2M subunits (94 and 180 kDa) and pMBP subunits (28 kDa) in SDS‐PAGE, which reacted with antibodies against α2M and pMBP‐28, respectively, in Western blotting. Furthermore, the α2M/pMBP‐28 complexes were demonstrated by electron microscopy, Fractionation of pMBP‐containing D‐mannose eluate from mannan‐Sepharose on Superose 6 showed two protein peaks which reacted with anti‐C1 s antibodies in ELISA, one of about 650–800 kDa, which in addition contained pMBP‐28 and anti‐α2M reactive material, the other with an Mr of 100–150 kDa. The latter peak revealed rhomboid molecules (7 × 15 nm) in the electron microscope and a 67 kDa band in SDS‐PAGE under reducing conditions. This band was also seen in eluates from the anti‐α2M and chelating Sepharose columns. Based on these observations and previous findings by other investigators of a serine protease with about 67 kDa subunits which copurifies with human MBP we propose a model for the interaction of pMBP‐28 with α2M. | [] | https://semanticscholar.org/paper/f4549a8931f43f2e66cddba858b4600eea153a96 | [] | [
{
"name": "P. STORGAARD",
"ids": [
"121022406"
]
},
{
"name": "E. HOLM NIELSEN",
"ids": [
"1914783928"
]
},
{
"name": "E. SKRIVER",
"ids": [
"5649939"
]
},
{
"name": "O. ANDERSEN",
"ids": [
"49584253"
]
},
{
"name": "S.‐E. SVEHAG",
"ids": [
"145866560"
]
}
] | [
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"0a85945ef63c03390419579e45a0138b42289000",
"a3f36d1f65647cee19fcd20aaa58a7a53740eedd",
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"f547cc249fc5c3b9a2fed3054cdd78d9a47d78ab",
"bf1c0e98b83a5f5aabd04617d0f9826a0cbc57fa",
"9dc7dd17d03503adbaead377ea31d708db038d44",
"f7bbb697c952f123d7f956336c952fb0a6844cb9",
"ebb1be0e6e3355802cfd4be1433a0ac5193c8d96",
"cbb5b3464037e9490c6b1a4e2534a18dd1a4256d",
"c76b7ea312190ffe2e398daa0843e9a7bbe6f229",
"8ed821b1251dbb17c521242515bafd73c88bf48f",
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"152cfb69a3becdc13da3a692fe35c61185bc361d",
"563fedaa4911e74a0b531b5a304b7591c77ced45",
"f88bd15d209ba64457c411f683af8dcfa69ff850",
"445a211d2bc52afc028bda979a2ffbd44cd281c0",
"3f2822ad0d14db26cf43b3b4dea3b9f12c44f002",
"9437a01febc4bac1e55da5fbd8ee7a2a3a0544b3",
"77bfa9b1114a548f12215d3f50041233609a3202",
"41b601014f203a5d37ad0842389ef589621e68c1",
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"8a8907f29b999d48a868f40586ecb32719b07387",
"5126bc6e64f6228919a5518ac95b1a6c2d86324e",
"984da52cdd09a078113f47b479500062ea7e3f03",
"77ff0bb96b1d085fe284c0a5d87d1d109001afcd",
"c11533dc7c73f4a218aeb7dbc767e4f2e7ebc13b",
"f9e44a16fed0f4bb47b2fec96bd998db19d05ae4",
"4bb4dbe95df740a3c071a87a4aeecbfc33d7fda3"
] | [
"Biology",
"Medicine"
] | 1,995 | Scandinavian journal of immunology | Scandinavian Journal of Immunology | 42 | [
"Medline"
] | 10.1111/j.1365-3083.1995.tb03670.x | https://doi.org/10.1111/j.1365-3083.1995.tb03670.x | 7544912 | 1981826658 |
||
7c0ae4fd7c82dca9fff07cdf709a05a585222720 | [Chemical constituents from roots of Ligularia intermedia]. | A new sesquiterpenoid, 8α-hydroxy-6β-methoxy-1-oxoeremophila-7 (11), 9 (10) -diene-12, 8-olide (1) and five known compounds, petasin (2), caffeic acid (3), hepta-cosanol (4), β-sitosterol (5) and β-daucosterol (6) have been isolated from the roots of Ligularia intermedia. The compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and identified based on spectral analyses (MS, 1H-NMR, 13C-NMR). | [] | https://semanticscholar.org/paper/7c0ae4fd7c82dca9fff07cdf709a05a585222720 | [] | [
{
"name": "Shu-li Li",
"ids": [
"15822088"
]
},
{
"name": "Xiang-mei Zhang",
"ids": [
"49469828"
]
},
{
"name": "Yu-heng Liu",
"ids": [
"46398655"
]
},
{
"name": "Qiu-juan Hao",
"ids": [
"12969335"
]
},
{
"name": "Na Li",
"ids": [
"145011164"
]
},
{
"name": "Rui-ping Zhang",
"ids": [
"49775406"
]
}
] | [] | [] | [
"Chemistry",
"Medicine"
] | 2,015 | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | 40 5 |
894-6
| [
"Medline"
] | 10.4268/cjcmm20150521 | https://doi.org/10.4268/cjcmm20150521 | 26087552 | 2420311350 |
|
b944350bda50268507c748bd28c44cf7ea142284 | Computational fluid dynamics study of the end-side and sequential coronary artery bypass anastomoses in a native coronary occlusion model. | OBJECTIVES
The objective of this study was to evaluate the haemodynamic patterns in each anastomosis fashion using a computational fluid dynamic study in a native coronary occlusion model.
METHODS
Fluid dynamic computations were carried out with ANSYS CFX (ANSYS Inc., Canonsburg, PA, USA) software. The incision lengths for parallel and diamond anastomoses were fixed at 2 mm. Native vessels were set to be totally occluded. The diameter of both the native and graft vessels was set to be 2 mm. The inlet boundary condition was set by a sample of the transient time flow measurement which was measured intraoperatively.
RESULTS
The diamond anastomosis was observed to reduce flow to the native outlet and increase flow to the bypass outlet; the opposite was observed in the parallel anastomosis. Total energy efficiency was higher in the diamond anastomosis than the parallel anastomosis. Wall shear stress was higher in the diamond anastomosis than in the parallel anastomosis; it was the highest at the top of the outlet. A high oscillatory shear index was observed at the bypass inlet in the parallel anastomosis and at the native inlet in the diamond anastomosis.
CONCLUSIONS
The diamond sequential anastomosis would be an effective option for multiple sequential bypasses because of the better flow to the bypass outlet than with the parallel anastomosis. However, flow competition should be kept in mind while using the diamond anastomosis for moderately stenotic vessels because of worsened flow to the native outlet. Care should be taken to ensure that the fluid dynamics patterns are optimal and prevent future native and bypass vessel disease progression. | [] | https://semanticscholar.org/paper/b944350bda50268507c748bd28c44cf7ea142284 | [] | [
{
"name": "Kaoru Matsuura",
"ids": [
"9614299"
]
},
{
"name": "Wei Wei Jin",
"ids": [
"47658688"
]
},
{
"name": "Hao Liu",
"ids": [
"48446613"
]
},
{
"name": "Goro Matsumiya",
"ids": [
"4720980"
]
}
] | [
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] | [
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"da7cb1d2139a9de3cf490f500a1712b00a9a8d8e"
] | [
"Medicine"
] | 2,018 | Interactive cardiovascular and thoracic surgery | Interactive cardiovascular and thoracic surgery | 26 4 |
583-589
| [
"Medline"
] | 10.1093/icvts/ivx376 | https://doi.org/10.1093/icvts%2Fivx376 | 29190348 | 2769248781 |
|
2715214b788e80588fa9672b01791c84c4327e6f | METABOLIC SYNDROME WITH CORONARY HEART DISEASE ON ELDERLY | Obesity, insulin resistance, dyslipidemia, and hypertension are the main components of the metabolic syndrome. Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in developed countries and developing. The aim of this study is to diagnose the disease, know the causes, the risk factors, the management, and to improve patient outcomes and increase patient knowledge along with awareness about the disease and the metabolic syndrome, especially coronary heart disease. Descriptive study in the case reports with data obtained derived from primary data obtained through anamnesis, physical examination and laboratory tests. Home visits for intervention and assessment of outcomes. Men, 65 years old, diagnosed with metabolic syndrome. Blood pressure was 200/110 mmHg, 68x pulse/minute, respiratory rate was 23x/min, temperature was 36,5 0 C, 150 cm of height, 75 kg of weight and the BMI was 33.33, waist length was 104 cm, at time blood glucose was 368 g/dl, had a history of recurrent chest pain. With the risk factors of smoking, lack of activity, and bad diet pattern. After the intervention there was improvement on knowledge of patients disease, decrease blood pressure and blood sugar level. [J Agromed Unila 2014; 1(2):156-160] Keywords : cardiovascular desease, lifestyle, metabolic syndrome | [] | https://semanticscholar.org/paper/2715214b788e80588fa9672b01791c84c4327e6f | [
"http://juke.kedokteran.unila.ac.id/index.php/agro/article/download/1321/pdf"
] | [
{
"name": "Intan Putri Prayitno",
"ids": [
"90611923"
]
}
] | [] | [
"31c933fd2735ec1c8444c9aae6c779b1bcd4dae3",
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"7b9d0fa1ca2ba8dfbffead12ecf54d15a10b6e8b",
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"c578f14384a7668f0f75cac9708845e041ffae90"
] | [
"Medicine"
] | 2,014 | 1 | 156-160 | [] | 2912780515 |
||||||
d4711c3068c779b7dfb430e442a7005c354a4e28 | Vitex negundo Linn.: phytochemical composition, nutritional analysis, and antioxidant and antimicrobial activity. | Vitex negundo (VN) is a widely used plant in folk medicine, namely for the treatment of jaundice, wounds, body ache, toothache, asthma, eye pain, and migraine. These effects have been increasingly attributed to its chemical composition. Here, we assessed the VN chemical and nutritional composition and biological activity, with particular emphasis on antioxidant and antimicrobial effects. VN methanol and hexane extracts revealed the presence of important phytochemical, such as terpenoids, polyphenol, steroids, saponins, phenolic compound and flavonoids. Total phenolic content of VN methanol extract from bark was 1082.473 mg/g GAE and that of leaves was 1382.984 mg/g GAE. The total flavonoids content in VN methanol extract from VN bark was 127.744 mg/g QE and that of leaves was 123.776 mg/g QE. VN methanol extract from bark exhibited high antioxidant effects (IC50=38.47 ppm). The content (%) of ash, moisture, crude fiber, crude protein and fat in VN leaves was, respectively, 7.86%, 18.35%, 6.52%, 9.687% and 6.19%. VN leaves methanol extract revealed antimicrobial activity against Bacillus subtilis and Staphylococcus aureus, with inhibition halos being, respectively, 13 mm and 14 mm, and the MBC values were found to be 1.562 mg/mL and 6.25 mg/mL, respectively. Similarly, VN bark methanol extract led to inhibition halos of 18 mm and 15 mm for B. subtilis and S. aureus, respectively, and the MBC values were found to be 2.372 mg/mL and 0.245 mg/mL. GC-MS analysis of the VN bark methanol extract revealed that monoolein was the major compounds, with an area of 0.57%. Thus, our results encourage the potential use of VN as a medicinal product, with high protein contents, and prominent antioxidant and anti-bacterial effects. | [] | https://semanticscholar.org/paper/d4711c3068c779b7dfb430e442a7005c354a4e28 | [] | [
{
"name": "Niranjan Koirala",
"ids": [
"2217905"
]
},
{
"name": "Chiran Dhakal",
"ids": [
"1768361420"
]
},
{
"name": "Nabin Narayan Munankarmi",
"ids": [
"46203400"
]
},
{
"name": "Shinawar Waseem Ali",
"ids": [
"16027876"
]
},
{
"name": "Aneela Hameed",
"ids": [
"76960035"
]
},
{
"name": "Natália Martins",
"ids": [
"144683333"
]
},
{
"name": "Javad Sharifi-Rad",
"ids": [
"93714524"
]
},
{
"name": "Muhammad Imran",
"ids": [
"1557022931"
]
},
{
"name": "Atta Muhammad Arif",
"ids": [
"144758535"
]
},
{
"name": "Muhammad Shakeel Hanif",
"ids": [
"145917468"
]
},
{
"name": "Ram Chandra Basnyat",
"ids": [
"1661109791"
]
},
{
"name": "Bahare Salehi",
"ids": [
"30451005"
]
}
] | [
"4259761f633ac6074a01e1aa140db10b90d3582a"
] | [] | [
"Chemistry",
"Medicine"
] | 2,020 | Cellular and molecular biology | Cellular and molecular biology | 66 4 |
1-7
| [
"Medline"
] | 10.14715/cmb/2020.66.4.1 | https://doi.org/10.14715/cmb%2F2020.66.4.1 | 32583767 | 3037846025 |
|
c8a421c1eb6664e8f56d6e7c1b388cd69dccb7cc | Modular Programming Concepts | You’ve almost surely had to deal with complexity in your software projects. The complexity level of a software application is usually low when development begins, but after a while the complexity begins to increase due to the changes performed on the platform. Complexity keeps increasing constantly as new features are added and the existing functionality is customized. The more changes and customizations are performed, the more complex the system becomes—it may get so complex that it becomes difficult for a new developer to ramp up on the project and be able to understand all its inner workings. And if the documentation of the system software isn’t good enough, then understanding the system becomes even harder. A high level of complexity requires more energy, resources, and time to be spent in order to understand the inner structure of the application. | [] | https://semanticscholar.org/paper/c8a421c1eb6664e8f56d6e7c1b388cd69dccb7cc | [] | [
{
"name": "Alexandru Jecan",
"ids": [
"35380731"
]
}
] | [] | [] | [
"Computer Science"
] | 2,017 | 1-16 | [] | 10.1007/978-1-4842-2713-8_1 | https://doi.org/10.1007/978-1-4842-2713-8_1 | 2757828646 |
|||||
04277d7fb30e523ed8cc682bf8bfacbe7c87e170 | Network Society | As a left-identified practitioner whose work has been, and continues to be, associated with the efforts of social change movements and activist groups, my own sense of individuality is often frustrated by the demands of group identification. This is a structuring tension within my artwork. I am constantly searching for a balance between my own sense of agency and my commitments to social change. | [] | https://semanticscholar.org/paper/04277d7fb30e523ed8cc682bf8bfacbe7c87e170 | [] | [
{
"name": "Gregg Bordowitz",
"ids": [
"119384751"
]
}
] | [] | [] | [] | 2,001 | Art Journal | 60 | 6 - 8 | [] | 10.1080/00043249.2001.10792058 | https://doi.org/10.1080/00043249.2001.10792058 | ||||
743a139f90025083723be91735aa1ff88d048925 | The Net-Model based Method of Target Value Analysis | Abstract According to the new characters of information age warfare, a net-model based method of TVA is put forward. The individual target value(ITV) is analyzed based on multi-level fuzzy comprehensive evaluation, the net target value(NTV) is analyzed using a method based on topological potential, and the final target value(FTV) is acquired through combining the prior two value parts using a method based on clustering coefficients of networks. The result of a arithmetic sample testify that the method proposed can serve for the target selecting problem of information age warfare. | [] | https://semanticscholar.org/paper/743a139f90025083723be91735aa1ff88d048925 | [] | [
{
"name": "Zhihong Deng",
"ids": [
"50663640"
]
},
{
"name": "SongYang Lao",
"ids": [
"1716428"
]
},
{
"name": "GuoHua Zhang",
"ids": [
"145351311"
]
},
{
"name": "Gang Liu",
"ids": [
"39738361"
]
}
] | [
"945ded8e73470731bfb02cbf6cf1e761c468ec46"
] | [
"71744ae3d04171f16c7e175369cc790faaeab7ff",
"a95dfda43cdf04761dab5c24082ed336ea839b64"
] | [
"Engineering"
] | 2,011 | Procedia Engineering | 15 | 1716-1721 | [] | 10.1016/J.PROENG.2011.08.320 | https://doi.org/10.1016/J.PROENG.2011.08.320 | 2017349519 |
|||
8c81d62dd12f6e58ed25b3c60083b76612cf5406 | Laplace Variational Approximation for Semiparametric Regression in the Presence of Heteroscedastic Errors | Variational approximations provide fast, deterministic alternatives to Markov chain Monte Carlo for Bayesian inference on the parameters of complex, hierarchical models. Variational approximations are often limited in practicality in the absence of conjugate posterior distributions. Recent work has focused on the application of variational methods to models with only partial conjugacy, such as in semiparametric regression with heteroscedastic errors. Here, both the mean and log variance functions are modeled as smooth functions of covariates. For this problem, we derive a mean field variational approximation with an embedded Laplace approximation to account for the nonconjugate structure. Empirical results with simulated and real data show that our approximate method has significant computational advantages over traditional Markov chain Monte Carlo; in this case, a delayed rejection adaptive Metropolis algorithm. The variational approximation is much faster and eliminates the need for tuning parameter selection, achieves good fits for both the mean and log variance functions, and reasonably reflects the posterior uncertainty. We apply the methods to log-intensity data from a small angle X-ray scattering experiment, in which properly accounting for the smooth heteroscedasticity leads to significant improvements in posterior inference for key physical characteristics of an organic molecule. | [] | https://semanticscholar.org/paper/8c81d62dd12f6e58ed25b3c60083b76612cf5406 | [] | [
{
"name": "Bruce D Bugbee",
"ids": [
"46857560"
]
},
{
"name": "F Jay Breidt",
"ids": [
"2184019"
]
},
{
"name": "Mark J van der Woerd",
"ids": [
"48400722"
]
}
] | [
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] | [
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"9dd2cbc04abb193093cf36a2b8de9fdc090e1f43",
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"012d057f4054e81bba610ea2a03527745321e377",
"aa5fb8e69a8bf518fb9eb36ec945b88faf01a52e",
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"e981f16fde9185373634b53d94baa1f9185ff890",
"87cbed883368d4a9efd42fdd91f47038f8d8fbe6",
"7c4f3e85144532cb7caca5fc26aa6ee87fbe941f",
"767ede637b59cce56272d133d33ec2f27b33e60a",
"2c7e4d6262775bca4c2616b7af9909d59718fcbe",
"566fbaf5dda324f3507262d76079e90e3f04dbfd"
] | [
"Mathematics",
"Medicine"
] | 2,016 | Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America | Journal of Computational and Graphical Statistics | 25 | 225 - 245 | [
"Medline"
] | 10.1080/10618600.2014.983642 | https://doi.org/10.1080/10618600.2014.983642 | 27667910 | 2030179284 |
|
83cc3ea458eb9989c8d277190bb50ced7c797e4a | Vnímání rizikových faktorů zdraví dětí mladšího školního věku. | My work forcuses on the bahaviour young adolescents. I m interested in the courent affairs of dependent drugs, mainly alcohol and cigarettes, unhealthy eating habits and the modern day sedentary lifestyle. In my research I want to find out what kids feel are hazads to their health, what they know about risk factors and whether there is sufgficient prevention at home or at school. Through my study I would like to support preventitive programs for children's health and raise awareness of the risk factors. | [] | https://semanticscholar.org/paper/83cc3ea458eb9989c8d277190bb50ced7c797e4a | [] | [
{
"name": "Aneta Bardodějová",
"ids": [
"81655763"
]
}
] | [] | [] | [
"Psychology"
] | 2,008 | [] | 2254533436 |
||||||||
960e54c8a8a97fd9f9363657239d982aa5850630 | 阅读训练（40）（英文） | Passage 1 Mr.Bean Have you ever watched movies and TV shows starring Rowan Atkinson？If you are not familiar with this name,does Mr.Bean ring a bell？Mr.Bean is a British TV show about an adult man called Mr.Bean,who has difficulty in completing even the simplest of tasks and whose life is | [] | https://semanticscholar.org/paper/960e54c8a8a97fd9f9363657239d982aa5850630 | [] | [
{
"name": "Dennis",
"ids": [
"1391018173"
]
},
{
"name": "Le",
"ids": [
"145512929"
]
},
{
"name": "Boeuf",
"ids": [
"1666206843"
]
},
{
"name": "景黎明",
"ids": [
"1478679118"
]
}
] | [] | [] | [
"Art"
] | 2,015 | 45-52 | [] | 2263573682 |
|||||||
2ddb8f72590c5064844de4fe7581a1e680115c01 | DETECTABILITY OF ABUSED DRUGS IN ORAL FLUID SAMPLES CORRESPONDING TO ANALYTICAL RESULTS IN THE RESPECTIVE BLOOD SAMPLES TAKEN AT ROADSIDE CONCERNING TRAFFIC OFFENCES | Recent studies have shown that there is a growing interest in the use of oral fluid as matrix for drug testing, especially from the police point of view. At present, the Institute of Legal Medicine Homburg/Saar, Germany, is co-operating with the German traffic police of the Saarland state and the Institute of Forensic Toxicology Frankfurt, Germany, in order to study how the detectability of abused drugs in saliva samples corresponds to analytical results in the respective serum samples. For this purpose, police officers will collect approx. 200 oral fluid samples from drivers during night controls, which are suspected to be influenced by drugs, and who have to undergo venipuncture. The oral fluid testing is done with a prototype version of the Draeger DrugTest, including collector, cartridges and reader. By using this system, not only an immediate screening result at the roadside is provided but also a confirmatory analysis due to withholding approx. 200 l of the oral fluid in the collector. The analyses of plasma and oral fluid samples are performed in blind modus: the serum samples will be analysed in Homburg/Saar and the oral fluid samples in Frankfurt/Main, respectively, analysis will be performed by solid-phase extraction, derivatization and GC-MS. The study was started recently and the results will be compared and evaluated with regard to all common drugs of abuse.(Abstract only) (A) For the covering abstract of the conference, see ITRD Abstract No. E201067. | [] | https://semanticscholar.org/paper/2ddb8f72590c5064844de4fe7581a1e680115c01 | [
"http://www.icadtsinternational.com/files/documents/2002_107.pdf"
] | [
{
"name": "Manfred R. Moeller",
"ids": [
"2898923"
]
},
{
"name": "G. Krauert",
"ids": [
"79692733"
]
},
{
"name": "H. J. Maurer",
"ids": [
"2165657"
]
},
{
"name": "Stefan Steinmeyer",
"ids": [
"1840660"
]
},
{
"name": "Stefan W. Toennes",
"ids": [
"5836661"
]
}
] | [] | [] | [
"Medicine"
] | 2,002 | 2002 | [] | 636881679 |
|||||||
995eab79e6e1cbc470579e68353a58d22c9f5f4f | Primary pulmonary hypertension: Current therapy. | Because the causes of primary pulmonary hypertension (PPH) remains unknown, the therapeutic approach of the disease can be only empirical, based on the pathology and pathobiology of pulmonary circulation. Despite the inability to cure the disease, therapeutic advances over the past 20 years have contributed to an improvement of quality of life and prolonged survival in PPH patients. Current therapeutic approach of PPH mostly includes limitation of physical activity, long-term anticoagulation, and vasodilator therapy. Among all tested oral vasodilators, calcium-channel blockers are the most efficient long-term therapies by improving symptoms and hemodynamics in a subset of PPH patients (10% to 15%) who acutely respond to such drugs. Acute pulmonary vasodilator response to inhalation of nitric oxide can predict acute and chronic responses to oral calcium-channel blockers. A better understanding of the pathogenesis of PPH has changed the focus of medical treatments from purely chronic vasodilator therapy to the evaluation of agents, such as prostaglandins, that may reverse the proliferation of pulmonary vascular cells and result in regression of the pulmonary vascular hypertrophy and remodeling. Long-term treatment with intravenous epoprostenol (prostaglandin I(2) or prostacyclin) improves exercise capacity, hemodynamics and survival in most patients with PPH in functional class NYHA III or IV, and may be currently considered as the "gold standard" therapy for severe patients. However, response to long-term epoprostenol therapy may be incomplete, adverse effects are common, and survival remains unsatisfactory (55% at 5 years). In such patients with severe pulmonary hypertension refractory to medical therapy, atrioseptostomy and lung transplantation can be indicated. | [] | https://semanticscholar.org/paper/995eab79e6e1cbc470579e68353a58d22c9f5f4f | [] | [
{
"name": "Olivier Sitbon",
"ids": [
"6697766"
]
},
{
"name": "Marc Humbert",
"ids": [
"145002982"
]
},
{
"name": "Gérald Simonneau",
"ids": [
"87546280"
]
}
] | [
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] | [
"Medicine"
] | 2,002 | Progress in cardiovascular diseases | Progress in cardiovascular diseases | 45 2 |
115-28
| [
"Medline"
] | 10.1053/PCAD.2002.128449 | https://doi.org/10.1053/PCAD.2002.128449 | 12411973 | 2035983530 |
|
51853f0d2640379c93e2bc518d3d5343d0e022e4 | Multiobjective static output-feedback control with control input constraint for a class of nonlinear systems | The robust static-output-feedback controller design is studied for a class of uncertain nonlinear systems with multiobjective constraints. The parameter uncertainties are allowed to be unstructured but norm-bounded. The nonlinear dynamics is described by vector-valued function. The aim is the design of static-output-feedback controller such that the closed-loop system is of robust stability, the magnitude of the control input is within the given bound, the prescribed constraint on the disturbance rejection is guaranteed, and the upper bound of quadratic cost function is optimized, simultaneously. The controller design is based on the Lyapunov stability theory and multiobjective optimization strategy, by using linear matrix inequality (LMI) approach. Matrix variable transformation technique is adopted in the design to convert the non-convex LMI constraints into convex ones. A numerical example is provided to illustrate the effectiveness of the proposed design algorithm. | [] | https://semanticscholar.org/paper/51853f0d2640379c93e2bc518d3d5343d0e022e4 | [] | [
{
"name": "Dengfeng Zhang",
"ids": [
"6653432"
]
},
{
"name": "Dexiao Xie",
"ids": [
"48811763"
]
},
{
"name": "Hong Wang",
"ids": [
"145121707"
]
},
{
"name": "Baochun Lu",
"ids": [
"37319137"
]
}
] | [
"3e9e02d3a49f04b786581501bf3e314ff72818a5",
"168c27c1ebdb56fd74edfd735c4b5a47e1949f23"
] | [
"478f2c0532369315c4a1d7b790685841c7def684",
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] | [
"Mathematics"
] | 2,011 | Proceedings of the 30th Chinese Control Conference | Proceedings of the 30th Chinese Control Conference | 2002-2007 | [] | 2139171858 |
|||||
dfbd73a84cc5d6372d5f4a72b83df6a58a2640f5 | On Mechanism of Interaction of Organophosphorus Inhibitors with Cholinesterases of Different Origin | A study is carried out as a development of A.P. Brestkin's concept of mechanism of irreversible inhibition of cholinesterases (ChE) by organophosphorus inhibitors (OPI) with taking into account reversibility of the first stage of this reaction, which has made it possible to determine individual constants of separate stages of the process. For the first time, a comparative study is performed on horse blood serum BuChE, human erythrocyte AChE, and ChE of optical ganglia of Pacific squid Todarodes pacificus. Besides, the OPI set is enlarged essentially due to use of some highly specific inhibitors of each of the enzymes. To evaluate the cholinesterase activity, chromogenic indophenol esters are used as substrates. For each of the studied ChE, differences in sensitivity to the studied OPI are realized only in values of the kinetic constant of formation of the enzyme-inhibitor complex (k5), whereas the rate constants of dissociation of this complex to initial components (ChE and OPI) (k−5) and of process of its transformation into phosphorylated ChE (k6) are close to each other by the values, values of these constants k−5 and k6 for different enzymes also being similar. Some statements about the molecular mechanism of the cholinesterase catalysis are formulated. It is suggested that the revealed elements of similarity of different ChE are realized in the work of the “catalytic machine” of active centers of the enzymes. | [] | https://semanticscholar.org/paper/dfbd73a84cc5d6372d5f4a72b83df6a58a2640f5 | [] | [
{
"name": "E. V. Rozengart",
"ids": [
"4878108"
]
},
{
"name": "N. E. Basova",
"ids": [
"5166377"
]
},
{
"name": "A. A. Suvorov",
"ids": [
"2254303"
]
}
] | [
"5224bba67d4971bc99c784df8118ace8782da1af"
] | [
"317efb133d01f7b383aa6d72830958345cf54131",
"5b913dcfff81efd2ef7b2d79176ef15366000daa",
"81a8b4c78d30e61663b6366518085b792dca00b8",
"35720923e88047a31479f4ddb1664707833e76cd",
"ab14ab6df759c777b8c9873609a7676a9a2988a8",
"5013c32e5f20c84183b7bf56faff123f9434d8f0",
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"dfdbcb657ca994798bf4c977180f4cb654c86030",
"832766f23689dc4ed0c49c697938977fe310b550",
"3199676e4b82d043c376fac80c7672a78538adc3",
"16b74326fd5398527f2e7c3c201ac1d3693ee6ff",
"8a76aedd716f9845a48f41c9269ad387c12ea762",
"38cabe6a21ab154af09de9916e7e72ff1693cb53",
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"779ea7c1d662df96e75bd7869a5921a33697b328"
] | [
"Chemistry"
] | 2,004 | Journal of Evolutionary Biochemistry and Physiology | Journal of Evolutionary Biochemistry and Physiology | 38 | 270-277 | [] | 10.1023/A:1020776324950 | https://doi.org/10.1023/A%3A1020776324950 | 106229404 |
||
3776b16a15be7a1a6f7af719a48fa4bfd46c0b89 | The pathogenesis, diagnosis and treatment of lupus nephritis | Purpose of reviewRenal involvement is a major cause of morbidity and mortality in systemic lupus erythematosus. In this review, we provide an update on recent discoveries in the pathogenesis, diagnosis, and treatment of lupus nephritis. Recent findingsLocalized long-lived plasma cells have been identified as playing an important role in lupus nephritis. In addition, the roles of aberrant expression of microRNAs and proinflammatory cytokines have been explored. Early diagnosis is important for effective treatment and multiple biomarkers have been identified; however, none has been yet validated for clinical use. Biomarker panels may turn out to be more accurate than each individual component. Biologic agents for the treatment of lupus nephritis are being studied, including belimumab which was recently approved for nonrenal systemic lupus erythematosus. Rituximab has not proven itself in large, placebo-controlled trials, although it is still being used in refractory cases of lupus nephritis. SummaryLupus nephritis is a potentially devastating complication of systemic lupus erythematosus. Immune cells, cytokines, and epigenetic factors have all been recently implicated in lupus nephritis pathogenesis. These recent discoveries may enable a paradigm shift in the treatment of this complex disease, allowing the tailoring of treatment to target specific pathogenic mediators at specific points in time in the progression of disease. Video abstracthttp://links.lww.com/COR/A20 | [] | https://semanticscholar.org/paper/3776b16a15be7a1a6f7af719a48fa4bfd46c0b89 | [] | [
{
"name": "Noa Schwartz",
"ids": [
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]
},
{
"name": "Beatrice Goilav",
"ids": [
"3763198"
]
},
{
"name": "Chaim Putterman",
"ids": [
"5436520"
]
}
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] | [
"Medicine"
] | 2,014 | Current opinion in rheumatology | Current Opinion in Rheumatology | 26 | 502–509 | [
"Medline"
] | 10.1097/BOR.0000000000000089 | https://doi.org/10.1097/BOR.0000000000000089 | 25014039 | 2063561966 |
|
c01110e77a8272907326324c4f5bd9e635645fe4 | Collective radiation biodosimetry for dose reconstruction of acute accidental exposures: a review. | Quantification of the biologically relevant dose is required to establish cause and effect between radiation detriment or burden and important biological outcomes. Most epidemiologic studies of unanticipated radiation exposure fail to establish cause and effect because researchers have not been able to construct a valid quantification of dose for the exposed population. However, no one biodosimetric technique (biophysical or biological) meets all the requirements of an ideal dosimeter. This paper reviews how the collection of biodosimetric data for victims of radiation accidents can be used to create a dosimetric "gold standard." Particular emphasis is placed on the use of electron spin resonance, a standard for radiation accident dosimetry. As an example of this technique, a review will be presented of a previously reported study of an individual exposed to a 60Co sterilization source. | [] | https://semanticscholar.org/paper/c01110e77a8272907326324c4f5bd9e635645fe4 | [
"http://ftp.ncbi.nlm.nih.gov/pub/pmc/05/4b/envhper00331-0025.PMC1469913.pdf",
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] | [
"Medicine",
"Biology"
] | 1,997 | Environmental health perspectives | Environmental Health Perspectives | 105 | 1397 - 1402 | [
"Medline"
] | 10.1289/EHP.97105S61397 | https://doi.org/10.1289/EHP.97105S61397 | 9467051 | 2091249191 |
|
de8885ac4bb41c3a5abf9a09244867cf4196cfc9 | Computer Control of a 3 MV Van de Graaff Accelerator | The development of accurate computer control of a 3 MV Van de Graaff accelerator operation is described. The developed system comprises the accelerator turn-on and turn-off procedures during a normal run, which includes the setting of the terminal voltage, ion source light up, beam focusing and control of ion beam current and energy during operation. In addition, the computer monitors t he vacuum and is able to make a detail register of the most important events during a normal run. The computer con trol system uses a LabVIEW application for interaction with the operator and an I/O board that interfaces the computer and the accelerator system. For everyday operating conditions the control implemented is able t o turn-on and off the machine in about the same time as a specialized technician. In addition, today more users can make experiments in the accelerator without the help of a specialized operator, which in turns increases the n umber of hours during which the accelerator can be used. | [] | https://semanticscholar.org/paper/de8885ac4bb41c3a5abf9a09244867cf4196cfc9 | [] | [
{
"name": "José Lopes",
"ids": [
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]
},
{
"name": "Francisco André Corrêa Alegria",
"ids": [
"2131902"
]
},
{
"name": "Luís Manuel dos Santos Redondo",
"ids": [
"2644514"
]
},
{
"name": "J. Rocha",
"ids": [
"78159550"
]
},
{
"name": "Eduardo Alves",
"ids": [
"48537550"
]
}
] | [] | [
"375652502e13a30b907e4c70d1b63b275eee7750",
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"d7f2d3d3a0f3effabf2657c6842fe748d2754905"
] | [
"Engineering"
] | 2,010 | Metrology and Measurement Systems | 17 | 415-425 | [] | 10.2478/V10178-010-0035-3 | https://doi.org/10.2478/V10178-010-0035-3 | 2150081616 |
|||
873311897c17d782531c3b7c6daf85524f8bc57b | Characteristics of four-wave mixing in a Bose-condensed atomic gas | An analysis is made of four-wave mixing of laser radiation interacting with an ultracold degenerate ensemble of boson atoms trapped in a magnetic trap. It is shown that the existence of long-range order in this type of atomic system leads to a new mechanism for the generation of the reversed wave whose experimental manifestation should differ from four-wave mixing in a nondegenerate gas. A similar nonlinear optical effect may be used for diagnostics of an ultracold gas at temperatures not much lower than the phase transition temperature. | [] | https://semanticscholar.org/paper/873311897c17d782531c3b7c6daf85524f8bc57b | [] | [
{
"name": "I. E. Mazets",
"ids": [
"2411264"
]
}
] | [] | [
"1b66d2412e87eb747f510a46192b952b6318b5f6",
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"52d618099b033fbfa414681024016462623d9bb7"
] | [
"Physics"
] | 1,999 | Technical Physics Letters | 25 | 911-912 | [] | 10.1134/1.1262681 | https://doi.org/10.1134/1.1262681 | 2017226109 |
|||
e07815772337cff7043ec8dcf5527c54d4825ae8 | Accounting Manipulations in Corporate Financial Reports: Study of an Asian Market. | Accounting manipulations (AM) in corporate 'financial reports' are perennial; they had occurred in all eras, in all countries and affected millions of corporations. Unfortunately, there are some 'loopholes' in accounting and auditing standards, which provide ample leeway to corporate managers and thus, motivate accounting professionals to make frequent manipulations in corporate financial reports. In fact, accounting manipulation (AM) involves the intentional 'cooking-up' of financial records & reports towards a pre-determined target. Every company indeed 'maneuvers' the numbers reported in its financial reports (FR), to a certain extent, to achieve their 'budgetary' targets and be generous to 'reward' senior managers. Factors such as greed, desperation, immorality and bad judgment drive some executives to 'fudge' the FR and account books. From Enron, WorldCom to Satyam, it appeared that window-dressing of FR leading to AM is a serious problem that is increasing both in its frequency and severity, which undermines the 'integrity' of FR and 'eroded' investors confidence. The responsibility of preventing, detecting and investigating financial frauds rests squarely on Board of Directors and they should adopt 'preventive' steps. Despite the 'raft' of CG, and financial disclosure 'reforms', corporate accounting still remains 'murky' and companies continue to find ways to play 'hide-and-seek' game with the FR system.
Satyam computers were once the 'crown-jewel' of Indian IT-industry but were brought to the ground by its founders in 2009 as a result of financial 'crime'. The present study provides a 'snapshot' of how Mr. Raju (CEO and Chairman) 'mastermind' this maze of AM practices? Undoubtedly, Satyam scam is 'illegal' and „unethical‟ in which computers were „cleverly‟ used to manipulate account books by creating fake invoices, inflating revenues, falsifying the cash and bank balances, showing non-existent interest on fixed deposits, showing ghost employees, and so on. Satyam fraud has 'shattered' the dreams of investors, 'shocked' the government and regulators and led to 'questioning' of the accounting practices of auditors and CG norms in India. An attempt has been made by the author to provide a description about the AM methodology used by the Satyam to commit the accounting fraud, duly supported by evidence wherever possible. Finally, we recommend that 'All types of AM practices should be legally recognized as crime and accounting bodies, law courts and other regulatory authorities must adopt exemplary punitive measures to prevent such unethical practices.' | [] | https://semanticscholar.org/paper/e07815772337cff7043ec8dcf5527c54d4825ae8 | [
"http://www.ijmsbr.com/Volume%205%20Issue%2011%20Paper%202.pdf"
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{
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"a7de113c4625ee39173ec5985f0a9912f4d922f8",
"0623300be0cc00b637881b88e056463f046e54c1",
"04c5b5661628e73852b096523b1892dead0e4e91",
"b1ecbdbea6093e38ff695ea3fd508f93a3eb5c5f",
"a63bbff1da770e591d7a4942b40553558d1faf77"
] | [
"Business"
] | 2,016 | [] | 2725922274 |
||||||||
e8ece627c9a412cd4f52870e4c0664334e09021e | Object's Shadow Removal with Removal Validation | We introduce in this paper, a shadow detection and removal method for moving objects especially for humans and vehicles. An effective method is presented for detecting and removing shadows from foreground figures. We assume that the foreground figures have been extracted from the input image by some background subtraction method. A figure may contain only one moving object with or without shadow. The homogeneity property of shadows is explored in a novel way for shadow detection and image division technique is used. The process is followed by filtering, removal, boundary removal and removal validation. | [] | https://semanticscholar.org/paper/e8ece627c9a412cd4f52870e4c0664334e09021e | [
"https://core.ac.uk/download/pdf/11785082.pdf"
] | [
{
"name": "M.A. As'ari",
"ids": [
"1398341453"
]
},
{
"name": "U.U. Sheikh",
"ids": [
"123580867"
]
},
{
"name": "S.A.R. Abu-Bakar",
"ids": [
"1405484198"
]
}
] | [
"007d805d1785ac0e4e97bce9bbf6932f1441823b"
] | [
"06acf09191dfbeb9d4b1921cbfc2ae9a04921dfd",
"77baefccc5c5dff744a61be2726f05c33bf26513",
"517252ac8ac51ac81af48a80dc641401c23e6527",
"358f9ec7d6ae06f95fdd6f4a3cf76b9aabd5e649",
"c2e2f9cff291b11451d886b090e5bc1538f92a83",
"7be89904f9705b978fe76d26e34d2589059bdd5f",
"aa8556a428b99f77241f584f19926dbb3d1e3ce0"
] | [
"Computer Science"
] | 2,007 | 2007 IEEE International Symposium on Signal Processing and Information Technology | 2007 IEEE International Symposium on Signal Processing and Information Technology | 841-845 | [] | 10.1109/ISSPIT.2007.4458149 | https://doi.org/10.1109/ISSPIT.2007.4458149 | 1971585983 |
|||
6c6024e36be1da1cd394f22e92013a10352d4d19 | Penerapan Total Quality Management terhadap Kepuasan Konsumen (Studi Kasus pada PT. Thirta Ikamakmur Perkasa) | Total Quality Management (TQM) is one way in which the use by companies to improve
product quality so that the results obtained would exceed the previous period. With the
Total Quality Management (TQM) in the company then the company can increase the
amount of consumer satisfaction, which is one important factor in the company for
future growth. The research method in use is the method of observation, interviewing
methods, and methods of literary study. By using this method, the researcher can obtain
all information relating to the Company or with Total Quality Management (TQM). The
results of the acquired company by using Total Quality Management (TQM) can be seen
from the number of sales companies continues to increase from period to period so the
company also increased the number of consumers. | [] | https://semanticscholar.org/paper/6c6024e36be1da1cd394f22e92013a10352d4d19 | [] | [
{
"name": "Hendrik Effendy",
"ids": [
"119818369"
]
}
] | [] | [] | [
"Business"
] | 2,010 | [] | 2437673192 |
||||||||
c038563869249f22cf707c100aba2365fa582987 | Population pharmacokinetics and dose optimization of ceftriaxone for children with community-acquired pneumonia | To assess ceftriaxone population pharmacokinetics in a large pediatric population and describe the proper dose for establishing an optimized antibiotic regimen. From pediatric patients using ceftriaxone, blood samples were obtained and the concentration was measured using high-performance liquid chromatography ultraviolet detection. The NONMEM software program was used for population pharmacokinetic analysis, for which data from 99 pediatric patients (2 to 12 years old) was collected and 175 blood concentrations were obtained. The best fit with the data was shown by the one-compartment model with first-order elimination. According to covariate analysis, weight had a significant impact on the clearance of ceftriaxone. Using Monte Carlo simulation, in a pediatric population with community-acquired pneumonia, a dose regimen of 100 mg/kg every 24 h produced satisfactory target attainment rates while remaining within the required minimum inhibitory concentration (2 mg/L). Population pharmacokinetics of ceftriaxone was evaluated in children and an optimum dosing regimen was constructed on the basis of the pharmacokinetics-pharmacodynamics model-based approach. | [] | https://semanticscholar.org/paper/c038563869249f22cf707c100aba2365fa582987 | [] | [
{
"name": "Muhammad Wasim Khan",
"ids": [
"46656712"
]
},
{
"name": "Ya-Kun Wang",
"ids": []
},
{
"name": "Yue-E Wu",
"ids": [
"6047831"
]
},
{
"name": "Bo-Hao Tang",
"ids": [
"9114405"
]
},
{
"name": "Min Kan",
"ids": [
"49044910"
]
},
{
"name": "Hai-Yan Shi",
"ids": [
"144160218"
]
},
{
"name": "Yi Zheng",
"ids": [
"93112438"
]
},
{
"name": "Bao-Ping Xu",
"ids": [
"4802500"
]
},
{
"name": "A-Dong Shen",
"ids": [
"153609422"
]
},
{
"name": "Evelyne Jacqz-Aigrain",
"ids": [
"1422092364"
]
},
{
"name": "Li-Yuan Tian",
"ids": [
"12172747"
]
},
{
"name": "Wei Zhao",
"ids": [
"49260570"
]
}
] | [] | [
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"54785ae7e482ce622e5ea08b3c6c809fb3fb72ae",
"9285d8e4b365abbc55b351e74f99143941842099",
"bf44f1af450dc391389e1790fa92bd27b0e61190",
"3df76d9c2fdf163eb9f221f138bcc34d2cec6d42",
"1d5011d727f1ca401b29dd3abc219796fb10a241",
"121b2079d6548c8a5f02456e266dc6dcedfdd15d",
"4d4edb714aa2efa51fff2699d7b811c74b6e9947",
"4139945839b225eec07e65e501af1e76127b1b18"
] | [
"Medicine"
] | 2,020 | European Journal of Clinical Pharmacology | European Journal of Clinical Pharmacology | 1 - 10 | [
"Medline"
] | 10.1007/s00228-020-02939-4 | https://doi.org/10.1007/s00228-020-02939-4 | 32583354 | 3037186979 |
||
fd0d8c126b4f42528953954cbbd42297b1e50003 | Real-time holographic gratings recorded in Norland Optical Adhesive 65 and yellow eosin | We recorded real time holographic gratings in a photosensitive liquid material. This material is Norland Optical Adhesive (NOA 65®) mixed with yellow eosin dye. The NOA 65® is a clear, colorless, liquid photopolymer that cures when is exposed to ultraviolet light (UV) but when is mixed with yellow eosin becomes sensitive to visible region. To record the gratings we used the interference between two diode laser, obtaining gratings by refraction index changes. We use two different wavelengths, for recording the gratings and its highest diffraction efficient was obtained when the grating was illuminated with a wavelength. | [] | https://semanticscholar.org/paper/fd0d8c126b4f42528953954cbbd42297b1e50003 | [] | [
{
"name": "María G. Conde-Cuatzo",
"ids": [
"1446717289"
]
},
{
"name": "Arturo Olivares-Pérez",
"ids": [
"1398638756"
]
},
{
"name": "Santa Toxqui-López",
"ids": [
"1412072090"
]
},
{
"name": "Israel Fuentes-Tapia",
"ids": [
"1404005953"
]
},
{
"name": "Mario A. Ambrosio-González",
"ids": [
"1486164025"
]
}
] | [] | [
"479c48282643587668d3e8ed2e636e5458478ced",
"87ced147aaf603ffe4f806e8a0e86103fbac2a4c",
"d3c4603a9caf335c112340fbe2c625dfbefd1264",
"5cf1f6a54cf10e060424e4033c2a126193a627c5",
"922e0cb9a4690b6bd6372dc4013b05c4cd049f90"
] | [
"Materials Science",
"Engineering"
] | 2,020 | OPTO | 11306 | 113060O - 113060O-7 | [] | 10.1117/12.2543591 | https://doi.org/10.1117/12.2543591 | 3007245228 |
|||
335eefa561eec22bdbecd55540f3f0500715de15 | Substrate-diamond interface considerations for enhanced thermionic electron emission from nitrogen doped diamond films | Thermionic electron emission from low work function doped diamond films can be related to materials' properties, which include donor states, surface electron affinity, and substrate-diamond interface properties. The focus of this study is on how the properties of the substrate material affect the emission. Two aspects are considered, the substrate electrical resistance and the substrate Richardson constant, and the effects of tungsten, molybdenum and rhenium substrates are explored. Low work function diamond films were deposited on the substrates, and the thermionic emission was measured to ∼530 °C and described in terms of a fit to the Richardson-Dushman formalism. The results establish that all surfaces exhibit a similar work function but the Richardson constant and maximum emission current vary considerably. The rhenium based emitter displayed a low work function of 1.34 eV, a significant Richardson constant of 53.1 A/cm2 K2, and an emission current density of ∼44 mA/cm2 at a temperature of 530 °C. The... | [] | https://semanticscholar.org/paper/335eefa561eec22bdbecd55540f3f0500715de15 | [] | [
{
"name": "Franz A. M. Koeck",
"ids": [
"30120992"
]
},
{
"name": "Robert Nemanich",
"ids": [
"144396716"
]
}
] | [
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"615c1ca0546230e10a4d2ac56b1796adba2005df",
"415280c185f37214bad8c94dc77467647efb79bb"
] | [
"Materials Science"
] | 2,012 | Journal of Applied Physics | 112 | 113707 | [] | 10.1063/1.4766442 | https://doi.org/10.1063/1.4766442 | 1982443013 |
|||
e071a489e5946b95b277dc7fa4551d69c6853172 | The Status Of Rural Women In China | Thank you very much for reading the status of rural women in china. Maybe you have knowledge that, people have search numerous times for their chosen novels like this the status of rural women in china, but end up in malicious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some malicious virus inside their desktop computer. the status of rural women in china is available in our book collection an online access to it is set as public so you can download it instantly. Our books collection spans in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the the status of rural women in china is universally compatible with any devices to read. | [] | https://semanticscholar.org/paper/e071a489e5946b95b277dc7fa4551d69c6853172 | [] | [
{
"name": "Juliane Hahn",
"ids": [
"4677611"
]
}
] | [] | [
"8e90640ddde9a253e14c06f2bd872cc883c93827"
] | [
"Political Science"
] | 2,016 | [] | 2517992664 |
||||||||
b3ef8d6ca7079afa0fdfe5f22ab725a454b04b75 | Project Cost Auditing Based on the immune system | Through the case analysis,the "immune system" idea is applied in the practice of the government investment projects cost auditing,and some beneficial experiences and understanding were summed up. | [] | https://semanticscholar.org/paper/b3ef8d6ca7079afa0fdfe5f22ab725a454b04b75 | [] | [
{
"name": "Shi Xiao-jun",
"ids": [
"1460353463"
]
}
] | [] | [] | [
"Business"
] | 2,011 | [] | 2384550051 |
||||||||
f0b2255b6e8f0bb587ad42a2ba4e746444bb0881 | Selfconsistent band structures and optical calculations in cubic ferroelectric perovskites | Abstract The band structures of SrTiO3 BaTio3 and KNbO3 in the cubic perovsikte structure are calculated using the first-prinicipals selfconsistent orthogonalized linear combination of atomic orbitals method. In all three crystals, indirect band gaps of about 3 eV are obtained. The top of the valence band is at R and the minimum in the conduction band is at f. Effective charge calculation and the charg. 1 density maps reveal the highly ionic nature of the crystal bonding in these ferroelectric crystals. The optical conductivities and the frequency dependent dielectric functions up to 20 eV in all three crystals are also evaluated using the energy eigenvalues and wave functions obtained from the band calculation. The calculated spectra are found to be in good agreement with the existing experimental measurements. | [] | https://semanticscholar.org/paper/f0b2255b6e8f0bb587ad42a2ba4e746444bb0881 | [] | [
{
"name": "Yong-Nian Xu",
"ids": [
"102861551"
]
},
{
"name": "Wai-Yim Ching",
"ids": [
"73639864"
]
},
{
"name": "Roger H. French",
"ids": [
"2047405"
]
}
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"1d9caabf7dae1e7891121265fb3668aa17a2699f"
] | [
"Physics"
] | 1,990 | Ferroelectrics | 111 | 23-32 | [] | 10.1080/00150199008217597 | https://doi.org/10.1080/00150199008217597 | 2014079959 |
|||
fec272a8632b5ef343375f25cc6544f1ffdb526a | Modular conveyor assembly having a stub attached inline roller | Modular conveyor assembly (10) includes a conveyor belt module for use with the in-line roller (12), the module having first and second hinge members (30, 32). First hinge member (30) extends ahead in the traveling direction of the conveyor, defining a first space extending along an axis (42) transverse to the traveling direction of the conveyor for the first hinge pin (40) fitted having a first opening (38). Second hinge member (32) extends along the axis (42) transverse to the traveling direction of the conveyor for fitting elongation in the opposite direction, the second hinge pin (40) and the first hinge member (30) a second opening defining a second space (52). Stubs (26) traverses the traveling direction of the conveyor extending from a first hinge member (30) surrounds at least a portion of the first space, the roller (28) so as to rotate about a first space attached rotatably to the stub. | [] | https://semanticscholar.org/paper/fec272a8632b5ef343375f25cc6544f1ffdb526a | [] | [
{
"name": "ディーン， エー． ウィーティング，",
"ids": [
"1415173541"
]
},
{
"name": "ケヴィン， エス． ハンセン，",
"ids": [
"1413947380"
]
}
] | [] | [] | [
"Engineering"
] | 2,004 | [] | 2760834591 |
||||||||
60e9665cede09e4d1df2fbae6bfe696d52e0e6e2 | NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants. | The ability of plants to repair DNA double-strand breaks (DSBs) is essential for growth and fertility. The Arabidopsis DSB repair proteins AtRAD50 and AtMRE11 form part of an evolutionarily conserved complex that, in Saccharomyces cerevisiae and mammals, includes a third component termed XRS2 and NBS1, respectively. The MRN complex (MRX in yeast) has a direct role in DSB repair and is also required for DNA damage signaling and checkpoint activation in a pathway mediated by the protein kinase ATM. This study characterizes Arabidopsis and maize NBS1 orthologues that share conserved protein motifs with human NBS1. Both plant NBS1 proteins interact with the corresponding MRE11 orthologues, and deletion analysis of AtNBS1 defines a region towards the C-terminus (amino acids 465-500) that is required for interaction with AtMRE11. Arabidopsis lines homozygous for a T-DNA insertional mutation in AtNBS1 display hypersensitivity to the DNA cross-linking reagent mitomycin C, and this phenotype can be rescued by complementation with the wild-type gene, consistent with a function for AtNBS1 in plant DSB repair. Analysis of atnbs1-1 atatm double mutants revealed a role for AtNBS1 in meiotic recombination. While atatm mutants produce reduced seed numbers, plants deficient in both AtATM and AtNBS1 are completely infertile. Cytological analysis of these double mutants revealed incomplete chromosome pairing and synapsis in meiotic prophase, and extensive chromosome fragmentation in metaphase I and subsequent stages. These results suggest a novel role for AtNBS1 that is independent of AtATM-mediated signaling and functions in the very early stages of meiosis. | [] | https://semanticscholar.org/paper/60e9665cede09e4d1df2fbae6bfe696d52e0e6e2 | [] | [
{
"name": "Wanda M Waterworth",
"ids": [
"4228159"
]
},
{
"name": "Cagla Altun",
"ids": [
"15835124"
]
},
{
"name": "Susan J Armstrong",
"ids": [
"7563350"
]
},
{
"name": "Nicola Roberts",
"ids": [
"47790136"
]
},
{
"name": "Philip J Dean",
"ids": [
"40182786"
]
},
{
"name": "Kim Young",
"ids": [
"49539757"
]
},
{
"name": "Clifford F Weil",
"ids": [
"38713364"
]
},
{
"name": "Clifford M Bray",
"ids": [
"3608577"
]
},
{
"name": "Christopher E West",
"ids": [
"2611116"
]
}
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] | [
"Biology",
"Medicine"
] | 2,007 | The Plant journal : for cell and molecular biology | The Plant journal : for cell and molecular biology | 52 1 |
41-52
| [
"Medline"
] | 10.1111/J.1365-313X.2007.03220.X | https://doi.org/10.1111/J.1365-313X.2007.03220.X | 17672843 | 2913027713 |
|
8f8d2abe3f0ba890be5de1af5e27484476aacb6a | Permanent uncoupling of male-specific CYP2C11 transcription/translation by perinatal glutamate. | Perinatal exposure of rats and mice to the typically reported 4mg/g bd wt dose of monosodium glutamate (MSG) results in a complete block in GH secretion as well as obesity, growth retardation and a profound suppression of several cytochrome P450s, including CYP2C11, the predominant male-specific isoform--all irreversible effects. In contrast, we have found that a lower dose of the food additive, 2mg/g bd wt on alternate days for the first 9days of life results in a transient neonatal depletion of plasma GH, a subsequent permanent overexpression of CYP2C11 as well as subnormal (mini) GH pulse amplitudes in an otherwise normal adult masculine episodic GH profile. The overexpressed CYP2C11 was characterized by a 250% increase in mRNA, but only a 40 to 50% increase in CYP2C11 protein and its catalytic activity. Using freshly isolated hepatocytes as well as primary cultures exposed to the masculine-like episodic GH profile, we observed normal induction, activation, nuclear translocation and binding to the CYP2C11 promoter of the GH-dependent signal transducers required for CYP2C11 transcription. The disproportionately lower expression levels of CYP2C11 protein were associated with dramatically high expression levels of an aberrant, presumably nontranslated CYP2C11 mRNA, a 200% increase in CYP2C11 ubiquitination and a 70-80% decline in miRNAs associated, at normal levels, with a suppression of CYP2C expression. Whereas the GH-responsiveness of CYP2C7 and CYP2C6 as well as albumin was normal in the MSG-derived hepatocytes, the abnormal expression of CYP2C11 was permanent and irreversible. | [] | https://semanticscholar.org/paper/8f8d2abe3f0ba890be5de1af5e27484476aacb6a | [] | [
{
"name": "Sarmistha Banerjee",
"ids": [
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]
},
{
"name": "Rajat Kumar Das",
"ids": [
"2562849"
]
},
{
"name": "Kelly A. Giffear",
"ids": [
"6655761"
]
},
{
"name": "Bernard H. Shapiro",
"ids": [
"34725865"
]
}
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] | [
"Biology",
"Medicine"
] | 2,015 | Toxicology and applied pharmacology | Toxicology and applied pharmacology | 284 1 |
79-91
| [
"Medline"
] | 10.1016/j.taap.2015.02.009 | https://doi.org/10.1016/j.taap.2015.02.009 | 25697375 | 2086150234 |
|
bb5a67cbab5dae932c43023e2b6b7910572a8175 | A Corynebacterium Plasmid Composed of Elements from Throughout the Eubacteria Kingdom | Publisher Summary This chapter discusses a corynebacterium plasmid composed of elements from throughout the eubacteria kingdom. The complete DNA sequence of the 51-kb multiresistance plasmid pTP10 from the Gram-positive human pathogen Corynebacterium striatum M82B provides genetic information about acquired resistance mechanisms to antimicrobial agents in this species. Analysis of the genetic organization of pTP10 suggests that the plasmid is composed of a mosaic structure comprising eight DNA segments, the boundaries of which are represented by horizontal mobile elements. The DNA segments of pTP10 turned out to be virtually identical to a plasmid-encoded macrolide and lincosamide resistance region from the human pathogen Corynebacterium diphtheriae, a chromosomal DNA region from Mycobacterium tuberculosis, a mobile chloramphenicol resistance region from the soil bacterium Corynebacterium glutamicum, several transposable elements from Gram-negative phytopathogenic Pseudomonas, Xanthomonas, and Erwinia species, and to a transposable aminoglycoside resistance region from the Gram-negative animal pathogen Pasteurella piscicida. | [] | https://semanticscholar.org/paper/bb5a67cbab5dae932c43023e2b6b7910572a8175 | [] | [
{
"name": "Andreas Tauch",
"ids": [
"34083304"
]
},
{
"name": "Alfred Pühler",
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"7663181"
]
}
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] | [
"Biology"
] | 2,002 | 29-36 | [] | 10.1016/B978-012680126-2/50006-2 | https://doi.org/10.1016/B978-012680126-2%2F50006-2 | 870940286 |
|||||
5c1f49c19c7bc2925916f905894c8406c115907f | Analysis of the (5d3 + 5d26s) – 5d26p Transitions of Ir VII | The spectra of iridium were photographed on 3-m and 6.65-m normal incidence spectrographs in the region 300–2100 A using a triggered spark source. The (5d3 + 5d26s) – 5d26p transitions were investigated. The configurations 5d3 and 5d26p had been previously studied which resulted in establishing all 19 levels of the 5d3 configuration and 44 out of 45 levels of the 5d26p configuration. In this analysis 15 out of 16 theoretically possible levels of the 5d26s configuration have been found which are based on 106 classified lines as being the transitions from the 5d26p configuration. All previously found levels in Ir VII have been confirmed. One missing level in the odd configuration has been established and 46 additional spectral lines have been identified as the 5d3 – 5d26p transitions in the ion. Calculated energy values and LS-compositions, obtained from the fitted parameter values using the orthogonal operator approach, are given for all levels of the three configurations. | [] | https://semanticscholar.org/paper/5c1f49c19c7bc2925916f905894c8406c115907f | [] | [
{
"name": "V I Azarov",
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"92871807"
]
},
{
"name": "S S Churilov",
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"91383934"
]
},
{
"name": "Y N Joshi",
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"145597562"
]
}
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"a58c6523265fbb35a8fcfecd8e56b9da4f06b83c"
] | [
"Physics"
] | 1,999 | Physica Scripta | 60 | 506-513 | [] | 10.1238/PHYSICA.REGULAR.060A00506 | https://doi.org/10.1238/PHYSICA.REGULAR.060A00506 | 1571142242 |
|||
f2815ee1a60142603e144a1a7636b912de445a2c | Quantum Dot Exciton Dynamics Probed by Photon-Correlation Spectroscopy | The dynamics of charging and recombination of photoexcited, site-controlled semiconductor quantum dots (QDs) are investigated using microphotoluminescence (PL) and photon-correlation spectroscopy combined with rate equation modeling. Several species of neutral and charged exciton complexes are identified in the PL spectra and their dynamics are evaluated by analyzing the temporal profiles of the second-order auto- and cross-correlation functions. The results provide insight into exciton dynamics relevant for designing QD structures for applications in quantum information processing and quantum communication systems. | [] | https://semanticscholar.org/paper/f2815ee1a60142603e144a1a7636b912de445a2c | [] | [
{
"name": "M. H. Baier",
"ids": [
"49590701"
]
},
{
"name": "Anton V. Malko",
"ids": [
"4918539"
]
},
{
"name": "Emanuele Pelucchi",
"ids": [
"6855249"
]
},
{
"name": "D. Y. Oberli",
"ids": [
"46725277"
]
},
{
"name": "Eli Kapon",
"ids": [
"97727494"
]
}
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"c861dbe72baacb8a270bcd80bdae7710b5b827c4"
] | [] | [
"Physics"
] | 2,006 | Physical Review B | 73 | 205321 | [] | 10.1103/PHYSREVB.73.205321 | https://doi.org/10.1103/PHYSREVB.73.205321 | 2059284910 |
|||
c742aae1783900ed1917eddd7321abfa91d22936 | The developmental cognitive neuroscience approach to the study of developmental disorders | Functional magnetic resonance imaging studies of developmental disorders and normal cognition that include children are becoming increasingly common and represent part of a newly expanding field of developmental cognitive neuroscience. These studies have illustrated the importance of the process of development in understanding brain mechanisms underlying cognition and including children in the study of the etiology of developmental disorders. Our current understanding of how the brain is organized owes a great deal to the study of brain lesions in adult patients. These studies have helped scientists gain insight into the brain mechanisms underlying language (Broca 1861), memory (Scoville & Milner 2000), attention (Posner et al. 1984), vision (Farah et al. 1989), and many other cognitive and perceptual systems. Thomas & Karmiloff-Smith (T&K-S) argue that it may not be appropriate to utilize the same adult patient model for the study of developmental disorders and the development of brain mechanisms for cognition. They make the case that it is imperative to take into account the process of development when studying developmental disorders. This argument has many implications, including the primary one emphasized by T&K-S, that one cannot equate developmental disorders with adult brain damage even if the symptoms are similar. Another implication of this argument is that it may be inappropriate to study the etiology of developmental disorders by studying adults who have the disorder. Most functional brain imaging studies of the etiology of developmental disorders use adult subjects. In the early days of brain imaging, when positron emission tomography (PET) was the only choice for studying functional localization in humans’ brains, this was a necessary experimental choice. PET requires the injection of radioactive isotopes and cannot be utilized in minors except in very specific circumstances. However, with the advent of functional magnetic resonance imaging (fMRI), a noninvasive technique for studying brain function and functional localization became available that can be used in children – as long as they are able to keep their movement restricted. Even with the advent of fMRI, many studies on developmental disorders have continued to use adult subjects. This practice reflects an assumption that the process of development is not important, and implies that the disrupted brain process associated with the disorder is isolated from and does not affect the rest of the brain. fMRI studies of developmental disorders and normal cognition that include children are becoming increasingly common and represent part of a newly expanding field of developmental cognitive neuroscience. These studies have already illustrated the importance of studying children as opposed to adults. Some results have confirmed previous adult findings, but others have shown differences between the adult and child organization. For example, a study of amygdala response to fearful faces in children (Thomas et al. 2001) showed less amygdala response in children as compared to adults; interestingly, this was because of an increased response in the children to the neutral faces. In a developmental study of inhibitory control (Luna et al. 2001), differences were found not only between children and adults but also in adolescents. Some of the brain differences shown in adolescents were different from both the children and the adults, illustrating the need to study the whole developmental trajectory (even in the relatively simple task of controlling eye movements). In addition, a study of cognitive control (Bunge et al. 2002) showed differences between adults and children in the brain regions associated with effective cognitive control, suggesting that the frontal network adults use to suppress interference and inhibit responses is not fully developed in children. In our own studies of developmental dyslexia, my colleagues and I have found both similarities and differences between children with dyslexia and adult studies of dyslexia. For example, we found that children with developmental dyslexia showed decreased activity in left hemisphere posterior language areas where adults with dyslexia had shown decreases in previous studies (Temple et al. 2001; 2003). This decrease in left temporo-parietal cortex has been shown in other studies of children (Shaywitz et al. 2002; Simos et al. 2002), suggesting that this disruption in temporo-parietal response seen in adults with dyslexia may be fundamental to the disorder (Temple 2002). However, in our studies we have also seen differences in the functional brain organization of children with dyslexia. We examined the brain response to rapid auditory stimuli in adults with dyslexia (Temple et al. 2000) and found that whereas normal reading adults showed left prefrontal responsivity to rapid auditory stimuli, the dyslexic reading adults did not show left prefrontal response to the same stimuli. In addition, two of three adult subjects who participated in a training program to improve their reading and rapid auditory processing ability showed increases in left prefrontal cortex after training. When we studied the brain response to rapid auditory processing in normal and dyslexic reading children (Temple 2001), we found some similarities to and differences from the adult study. In normally reading children, left prefrontal cortex was responsive to rapid auditory stimuli, but other brain regions were also involved in a network of response that was more distributed than we had seen in adults. In children with dyslexia, we saw the same lack of prefrontal responsivity to rapid auditory stimuli that we had seen in adults, but we also saw lack of response in the whole larger network of brain areas responsive in normally reading children. After training we saw increased activity in not only the left prefrontal cortex of the children with dyslexia but across the larger network. These results suggest to us that the neural response to rapid auditory stimuli undergoes developmental changes from childhood to adulthood, becoming more focused and involving an increasingly smaller network. In addition, this study suggests that this larger network is disrupted in developmental dyslexia and the results seen in adults with dyslexia represent only one aspect of the disrupted response seen in children with dyslexia. These examples of recent studies of normal and abnormal developmental cognitive neuroscience illustrate the point that the brain mechanisms involved in cognitive processes do undergo developmental changes. In the case of developmental disorders, it may be that entire networks are disrupted. Taking these processes of development into account may be crucial to our understanding of the etiology of developmental disorders. I would argue that, when feasible, studies of the neurobiology underlying developmental disorders as well as normal cognitive functioning should be conducted with children and taking the process of development into account. Models of atypical development must also be models of normal development Gert Westermann and Denis Mareschal Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, London WC1E 7HX, United Kingdom. {g.westermann; d.mareschal}@bbk.ac.uk http://www.cbcd.bbk.ac.uk/people/gert; denis/ Abstract: Connectionist models aiming to reveal the mechanisms of atypConnectionist models aiming to reveal the mechanisms of atypical development must in their undamaged form constitute plausible models of normal development and follow a developmental trajectory that matches empirical data. Constructivist models that adapt their structure to the learning task satisfy this demand. They are therefore more informative in the study of atypical development than the static models employed by Thomas & Karmiloff-Smith (T&K-S). Commentary/Thomas & Karmiloff-Smith: Are developmental disorders like cases of adult brain damage? BEHAVIORAL AND BRAIN SCIENCES (2002) 25:6 771 As demonstrated here by Thomas & Karmiloff-Smith (T&K-S), neural network models are a useful tool for assessing how damage at different stages of development affects the outcome of learning. However, if the specific results gained with models are to inform studies of atypical development in children, it is important that the models used to simulate atypical development should otherwise also constitute realistic models of normal development. Only if a model can give a good account of how development proceeds under normal circumstances, will damaging this model yield insights into the mechanisms of atypical development. Both in reading and in past-tense acquisition, a plethora of data exists about the normal course of acquisition and the resulting adult processing system. Pervasive here are dissociations between regular and irregular forms in past-tense learning (Marcus et al. 1992), and between normal words and exception words in reading (Backman et al. 1984). It is important to establish that these developmental dissociations also exist in a model that is later used to explain atypical development by varying its parameters. This is not because the observed developmental profile is significant per se, but because it reveals important aspects of the underlying learning mechanisms, such as the internal reorganization of representations or the extraction of higher-order features from the learned data. Even if a model of learning that does not follow a realistic developmental course reaches a 100% success rate, it is unclear if it does so in ways that are comparable with children’s learning, and hence, if damage to the model is comparable to damage to the child’s learning system, that is, the brain. The analogy between atypical development and learning in a damaged model can thus only hold if the undamaged model can be shown to progress through a realistic course of acquisition, and preferably if the trained model displays dissociation | [] | https://semanticscholar.org/paper/c742aae1783900ed1917eddd7321abfa91d22936 | [
"http://psych.brookes.ac.uk/publications/BBSThomasKS2002.pdf"
] | [
{
"name": "Elise Temple",
"ids": [
"35048066"
]
}
] | [
"1bd7d45d905e908e00f8a53d90bfdcc5b455b40c",
"70456482a15309bfcd5b475209d61a56df211bae"
] | [] | [
"Psychology"
] | 2,002 | Behavioral and Brain Sciences | 25 | 771-771 | [] | 10.1017/S0140525X02420134 | https://doi.org/10.1017/S0140525X02420134 | 2057365726 |
|||
9d6a5d9d8266afbe11d6e8c22f712415ee47549f | Detection of Immunoglobulin κ,λ Light Chain Restriction in Mantle Cell Lymphoma Using Immunohistochemistry and In Situ Hybridization | Objective To evaluate the application value of immunohistochemistry combined with in situ hybridization for detecting immunoglobulin κ,λ light chain restriction in mantle cell lymphoma(MCL).Methods The expression of CyclinD1 was detected by immunohistochemistry using Envision two step method in 15 cases of nodular mantle cell lymphoma(group 1),15 cases of diffuse mantle cell lymphoma group(group 2) and 10 cases of reactive lymph node hyperplasia(control group).The κ to λ light chain ratio was measured by in situ hybridization to determine the light chain restriction of tumor cells.Results CyclinD1 was positively expressed in nodular mantle cell lymphoma and diffuse mantle cell lymphoma(15/15,100.0%),but was not expressed in the surrounding residues or lymphocytes with reactive hyperplasia.In group 1,κ light chain restriction was found in 7 cases(7/15,46.7%),λ light chain restriction in 3 cases(3/15,20.0%),and no light chain restriction in 5 cases(5/15,33.3%).In group 2,κ light chain restriction was found in 2(2/15,13.3%),λ light chain restriction in 6 cases(6/15,40.0%),and no light chain restriction in 7 cases(7/15,46.7%).No cases showed light chain restriction in control group.Conclusion The light chain restriction and types can be detected by cyclin D1 immunohistochemistry and in situ hybridization in different types of MCL.Therefore,the combined detection is important for early diagnosis of MCL. | [] | https://semanticscholar.org/paper/9d6a5d9d8266afbe11d6e8c22f712415ee47549f | [] | [
{
"name": "Mei Jin-hong",
"ids": [
"1431601482"
]
}
] | [] | [] | [
"Biology"
] | 2,012 | Journal of Nanchang University | [] | 2349046014 |
|||||||
cc43c62702e979e4ac936c0a165ecd2b8207fda8 | An improved hybrid PN code acquisition for CDMA personal wireless communications | This paper proposes an improved decision s t ra tegy for noncoherent hybrid parallel pseudonoise (PN) code acquisition and analyzes the acquisition performance in the presence of multiple access interference (MAI) over Rayleigh and Rician fading channels for code-division multiple access (CDMA) personal wireless communications. The hybrid acquisition scheme combines parallel search wi th serial search t o cover the whole uncertainty region of the input code phase. The closed-form expressions of the detection and false-alarm probabilities and mean acquisition time are derived. It is shown that, (i) the scheme achieves both better acquisition performance and simpler acquisition hardware structure than total parallel acquisition in the case of severe MAI, and (ii) the increase of mean acquisition time (due t o MAI) depends on the number of users in the CDMA system, PN code search strategy, system design parameters, and channel fading statistics. | [] | https://semanticscholar.org/paper/cc43c62702e979e4ac936c0a165ecd2b8207fda8 | [
"https://doi.org/10.1109/PIMRC.1995.477093"
] | [
{
"name": "Weihua Zhuang",
"ids": [
"143887379"
]
}
] | [
"50531eb8d73a81a09b6dca74206f1597615f0b41",
"8168f04c3d2c0293c1a245b472fb83d02d594e9b"
] | [
"e4c18422bf6f7f3f9fdc3191d710b6ec79c95883",
"45d6b1de6697ece44f342d1c4d181853d0648fa1",
"7012ca491e4bb28ace20db14bd38df39718b7c99",
"a606b98da08285e704a6a2ede44776c6196ad342"
] | [
"Computer Science"
] | 1,995 | Proceedings of 6th International Symposium on Personal, Indoor and Mobile Radio Communications | Proceedings of 6th International Symposium on Personal, Indoor and Mobile Radio Communications | 3 | 995- | [
"DBLP"
] | 10.1109/PIMRC.1995.477093 | https://doi.org/10.1109/PIMRC.1995.477093 | 2126902208 |
||
2e9c66d58210fac18b6671f3dc1dabd3947023e9 | Modeling Motion Uncertainty of Moving for Robot Motion Planning 0 bst acles | This paper describes a method of modeling the mot ion uncertainty of moving obstacles and ats applicat ion t o mobile robot motion planning. The method explicitly considers three sources of motion uncertainty: path ambiguity, velocity uncertainty, and observation uncertainty. The model is represented by a probabilist ic distribution over possible position on a path of a moving obstacle. Using this model, the best robot mot ion is selected which minimizes the expected t ime of reaching the destination. B y considering not the range but the distribution of the uncertainty, more efficient behaviors of the robot are realized. | [] | https://semanticscholar.org/paper/2e9c66d58210fac18b6671f3dc1dabd3947023e9 | [
"https://ir.library.osaka-u.ac.jp/repo/ouka/all/14068/00846363.pdf"
] | [
{
"name": "Jun Miura",
"ids": [
"1691940"
]
},
{
"name": "Yoshiaki Shirai",
"ids": [
"1700379"
]
}
] | [] | [
"99a467f4c641b79a2d49dc97f2319d619d148b6a",
"db0d378393108f9ac0188fa2da043a81ea54f7b8",
"ef22e1bb6d1c4afc4ad349f30d196d1af67ff89f",
"ea3dc30c589e77fd00ad51f18ee9e0ba5644a5b9",
"856db70493cfdc807d992f588eeba0b220ce39e2",
"da6ccc55a7869faf7878433e5650a445b37a2060"
] | [] | -1 | [] | |||||||||
a4ef3db562b2f8f51ca97fdb0b468ee0f513507a | Perturbation treatment of electron-phonon-coulomb system in normal metals in a pseudopotential model | Abstract The electron-electron and the electron-phonon interactions in the combined perturbation formalism of Simkin have been studied in a pseudopotential model to include the effect of core electrons on the electronic specific heat of simple metals. The use of the model pseudopotential is found to remove the divergences occurring in the usual perturbation expansion for electron interactions and leads to an effective screened interaction between electrons in the low-momentum transfer region. Results of the theoretical results and agree fairly well with the experimental results. | [] | https://semanticscholar.org/paper/a4ef3db562b2f8f51ca97fdb0b468ee0f513507a | [] | [
{
"name": "V. K. Saxena",
"ids": [
"87870684"
]
},
{
"name": "D. L. Bhattacharya",
"ids": [
"144260382"
]
}
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] | [
"Mathematics"
] | 1,970 | Physica D: Nonlinear Phenomena | 49 | 197-216 | [] | 10.1016/0031-8914(70)90170-9 | https://doi.org/10.1016/0031-8914%2870%2990170-9 | 1974221684 |
|||
d765ab65a804ad806111b52999427ecbe164d4e0 | Constrained and Unconstrained Hardware-Software Partitioning using Particle Swarm Optimization Technique | In this paper we investigate the application of the Particle Swarm Optimization (PSO) technique for solving the Hardware/Software partitioning problem. The PSO is attractive for the Hardware/Software partitioning problem as it offers reasonable coverage of the design space together with O(n) main loop's execution time, where n is the number of proposed solutions that will evolve to provide the final solution. We carried out several tests on a hypothetical, relatively-large Hardware/Software partitioning problem using the PSO algorithm as well as the Genetic Algorithm (GA), which is another evolutionary technique. We found that PSO outperforms GA in the cost function and the execution time. For the case of unconstrained design problem, we tested several hybrid combinations of PSO and GA algorithms; including PSO then GA, GA then PSO, GA followed by GA, and finally PSO followed by PSO. The PSO algorithm followed by another PSO round gave the best result as it allows another round of domain exploration. The second PSO round assign new randomized velocities to the particles, while keeping best particle positions obtained in the first round. We propose to name this successive PSO algorithm as the Re-excited PSO algorithm. The constrained formulations of the problem are investigated for different tuning or limiting design parameters constraints. | [] | https://semanticscholar.org/paper/d765ab65a804ad806111b52999427ecbe164d4e0 | [
"https://doi.org/10.1007/978-0-387-72258-0_18"
] | [
{
"name": "Mohamed B. Abdelhalim",
"ids": [
"144082198"
]
},
{
"name": "A. E. Salama",
"ids": [
"39707207"
]
},
{
"name": "Serag E.-D. Habib",
"ids": [
"121383695"
]
}
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] | [
"Computer Science"
] | 2,007 | IESS | 207-220 | [
"DBLP"
] | 10.1007/978-0-387-72258-0_18 | https://doi.org/10.1007/978-0-387-72258-0_18 | 1490332210 |
||||
67c72de7520539dbb0e2a7029ebf1a819f85ca07 | Antiplane strain in a nonlinearly elastic incompressible body | The stress-strain state of an incompressible cylindrical elastic body with antiplane strain under the action of potential forces and surface loading constant along the body is considered in a nonlinear formulation in actual variables. The stresses are expressed via the pressure and independent strains, the pressure is expressed via the force and elastic potentials, and nonlinear boundary-value problems are posed for strains (and displacements). Various methods for solving these problems are developed. For the nonlinear equations obtained, some analytical solutions containing free parameters are given, which can be used as a basis for solving particular problems. | [] | https://semanticscholar.org/paper/67c72de7520539dbb0e2a7029ebf1a819f85ca07 | [] | [
{
"name": "B. D. Annin",
"ids": [
"100746759"
]
},
{
"name": "V. D. Bondar’",
"ids": [
"91578611"
]
}
] | [
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] | [
"Physics"
] | 2,006 | Journal of Applied Mechanics and Technical Physics | 47 | 849-856 | [] | 10.1007/S10808-006-0124-Y | https://doi.org/10.1007/S10808-006-0124-Y | 1974346327 |
|||
6884cba7b279240a818c6f96d4085b0976ecb199 | A Minimal Pair of Recursively Enumerable Degrees | Our principal result is that there exist two incomparable recursively enumerable degrees whose greatest lower bound in the upper semilattice of degrees is 0. This was conjectured by Sacks [5]. As a secondary result, we prove that on the other hand there exists a recursively enumerable degree a < 0(1) such that for no non-zero recursively enumerable degree b is 0 the greatest lower bound of a and b. The proof of the main theorem involves a method that we have developed elsewhere [8] to deal with situations in which a partial recursive functional may interfere infinitely often with an opposed requirement of lower priority. A different method of handling such problems has been previously introduced by Sacks [5] and used by him to prove that the recursively enumerable degrees are dense [6]. In the definition of two recursively enumerable degrees which are merely incomparable, as in the original papers of Friedberg [1] and Mucnik [3], each partial recursive functional eventually ceases to interfere with the construction, although there is no effective procedure for deciding at which state in the construction this occurs. Our second theorem provides another variation on this theme. ' All the necessary background material may be found in [2] and [5]. If e is a number and A is a set, then we define the partial function (' by setting: | [] | https://semanticscholar.org/paper/6884cba7b279240a818c6f96d4085b0976ecb199 | [
"https://www.wikidata.org/entity/Q56430706"
] | [
{
"name": "C. E. M. Yates",
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] | [
"Mathematics",
"Computer Science"
] | 1,966 | J. Symb. Log. | J. Symb. Log. | 31 | 159-168 | [
"DBLP"
] | 10.2307/2269807 | https://doi.org/10.2307/2269807 | 2051601785 |
||
39779fe7a08d7b3d696c44bc6ec799116b835072 | An inverse method to determine the temperature profile on a semiconductor power diode | An approach is developed to determine the nonuniform temperature profile on a semiconductor power diode. The temperature distribution over the large junction area of power semiconductor devices is often nonuniform due to voids or cracks in the mountdown media. Since the device packaging typically prevents direct measurement of the junction temperature, the presented technique requires the measurement of voltages and currents only. No information regarding the size or type of the void is required, and heat transfer equations are not solved. Instead, the temperature distribution is calculated using current-voltage-temperature relationships similar in form to the Shockley equation. Using these relationships, the temperature across the junction are calculated as a best fit to the voltage and current measurements. This inverse method is tested using a power diode 18 mm in diameter and rated at 100 A. Preliminary measurements indicate that the method calculates peak junction temperature as accurately as existing techniques.<<ETX>> | [] | https://semanticscholar.org/paper/39779fe7a08d7b3d696c44bc6ec799116b835072 | [] | [
{
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{
"name": "E. Rodriguez",
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"83389d94fe23b049bbddb2f3de2c855e84389970",
"559317b01cd21475982a0cdd21fa409bf978726d",
"731a54674f5e90fbebb3e4a7d0a8371f37124889",
"5dfd7ae436997502efbe1a4cb04c960594f567ab"
] | [
"Engineering"
] | 1,988 | InterSociety Conference on Thermal Phenomena in the Fabrication and Operation of Electronic Components. I-THERM '88 | InterSociety Conference on Thermal Phenomena in the Fabrication and Operation of Electronic Components. I-THERM '88 | 7-14 | [] | 10.1109/ITHERM.1988.28669 | https://doi.org/10.1109/ITHERM.1988.28669 | 2129757820 |
|||
17bc2ec2fd7bc59ce37ead3671a7b8442fc5d99c | On the Component and Measurement for the Price of Natural Resources | The price of natural resources includes the cost of production,the efficiency of natural resources and the influence of rare natural resources;the measurement of natural resources is first to measure the cost of production,the efficiency of natural resources and the influence of the rare natural resources and then draw the measuring patters for the price of natural resources. | [] | https://semanticscholar.org/paper/17bc2ec2fd7bc59ce37ead3671a7b8442fc5d99c | [] | [
{
"name": "AN Xiao-ming",
"ids": [
"122005769"
]
}
] | [] | [] | [
"Economics"
] | 2,004 | [] | 2377046553 |
||||||||
c47c96e18f17ee9a05fbea65269ec074173f579c | Suppression of spinach wilt disease by biological soil disinfestation incorporated with Brassica juncea plants in association with changes in soil bacterial communities | Abstract Biological soil disinfestation (BSD) is a method of controlling soil-borne pests and diseases through anaerobic decomposition of plant biomass incorporated in field soil with temporary irrigation and covering with sheets. In this study, effects of BSD on suppression of spinach wilt disease were investigated in two different field experiments using mainly Brassica juncea plants as plant biomass. Soil bacterial community compositions were analyzed with clone library analysis based on 16S rRNA gene sequences to determine the relationship between the bacterial composition in the treated soil and suppression of the disease. For the BSD-treated soils, oxidation–reduction potential dropped, and acetate was usually detected at high concentrations. Although the control treatment (irrigation and polythene covering without biomass) decreased the wilt disease incidence in spinach plants cultivated in the treated plot as compared with those for the non-treated plot, BSD-treatments suppressed the disease more effectively. The clone library results showed that both non-treated and control soils contained diversified bacterial communities of various phylogenetic groups, while members of the Firmicutes mainly from the class Clostridia dominated in the BSD-treated soils. The clostridial groups detected were diverse and the major clone groups were closely related to strictly anaerobic fermentative bacteria such as Clostridium saccharobutylicum , Clostridium cylindrosporum , Clostridium sufflavum , and Clostridium xylanovorans . These clostridial groups were almost eliminated from the soil bacterial community when the BSD-treated soil was treated again with irrigation and covering without biomass before the next cropping, in which the wilt disease was hardly suppressed. | [] | https://semanticscholar.org/paper/c47c96e18f17ee9a05fbea65269ec074173f579c | [
"https://swfrec.ifas.ufl.edu/docs/pdf/veg-hort/asd/Suppression_spinach_wilt_disease_BSD.pdf"
] | [
{
"name": "Subrata Mowlick",
"ids": [
"5650465"
]
},
{
"name": "Hitoshi Yasukawa",
"ids": [
"87981436"
]
},
{
"name": "Takashi Inoue",
"ids": [
"48245085"
]
},
{
"name": "Toshiaki Takehara",
"ids": [
"6497426"
]
},
{
"name": "Nobuo Kaku",
"ids": [
"47345004"
]
},
{
"name": "Katsuji Ueki",
"ids": [
"144985298"
]
},
{
"name": "Atsuko Ueki",
"ids": [
"38940598"
]
}
] | [
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"3c1fc407fcd578222bfacf813e990a29ef074d84",
"3bbe12cc32e9aa56f1b3d7e7efd891b9c33497a0",
"cac45542efb47c3ecb2330d92afa1b5753cfedc4",
"7fbf5488519a0431deaedefb1b53c007a2edee30",
"614bbeaf1f9f744b22b16354348059c6abd618e9",
"1dc0342e7fc4b127ebf40c0ad110d5d96154f62c",
"ccd5198006ff8b8ac8b2ab2189a9f6a590ea7db6",
"ce658fa7352781db1dde7549008875dac4154a19",
"c1262257ea0bd3d67fbb4e77d02fb0af7a2126d2",
"83c14b4153a7d7c966eb7ba4e27c0cc78fb82ee3",
"0deeb10ad155e705dbf991516c43240b918ad1f5",
"6039d51d32461c2f723ecc13075653a4f4b85bcf",
"15be283d821e46e6606e58a894e9046ddca349ba",
"00865424a1a913b5685c8378000bf8edafdbb645",
"d18e78a413bcc3ca872a47fe67dee7b44aaa43f4",
"e6f6e37f585f43f28f60d6b12e5edb92d8b7a2b9",
"8c978533b7c00bcfa1ba53611404ba26c3462bb3"
] | [
"Biology"
] | 2,013 | Crop Protection | 54 | 185-193 | [] | 10.1016/J.CROPRO.2013.08.012 | https://doi.org/10.1016/J.CROPRO.2013.08.012 | 2019245888 |
|||
5a2fe58d7781811ba01b5f6eb86777d05b76701e | Durability of earthen architecture ruins under cyclic wetting and drying | Cyclic wetting-drying were conducted on the undisturbed and remolded specimens from Jiaohe cultural heritage,Xinjiang,China to understand the durability of earthen architecture to wind erosion and the strength attenuation.Test result shows,under the circumstance of the low original water content,the specimens weight is increased during the beginning three wetting-drying cycles,and then proceeds to a relatively steady state.With the change of moisture content during the condensation-evaporation process,specimen weight expressed a decreasing tendency.With the increase in wetting-drying cycles,undisturbed specimens shows a decrease in compressive strength and an increase in wind erosion quantity,reflecting a weakening effect of durability.Comparatively,remolded specimen shows an increase in strength and a decrease in wind erosion quantity,or an inhencing effect of durability at the early wetting-drying cycles;but during the later cycles,a decrease in strength and an increase in wind erosion quantity,or weakening durability is found.It is considered the healing of destroyed microstructure during remolding and the aging of chemical cohesive agents are responsible for the strengthening of remolded specimen at the earlier wetting-drying cycles. | [] | https://semanticscholar.org/paper/5a2fe58d7781811ba01b5f6eb86777d05b76701e | [] | [
{
"name": "Zhang Yong-xia",
"ids": [
"152563126"
]
}
] | [
"a93536e0b63d37a4b1e3d89d0c696bb994e306bb",
"1b4d8a716377877d17672c5ea3efefe3fcae6fad",
"4343cf62e08d54e520d3b48325544b9a4cce711e"
] | [] | [
"Geology"
] | 2,011 | Rock and Soil Mechanics | [] | 2349474244 |
|||||||
161f155fc3872d8a02f66c601727f2d819daa272 | Societal Response and the Moral Regulation of Public-Space Drinking | These articles on moral regulation (Torronen and Karlsson) and social control (Wacklin) of public space are broadly cast so that drinking and its control are framed and seen as representative (symbolic) of broader ideologies about the nature of responsible and appropriate behavior in public and private life. This approach is consistent with the classic work of Joseph Gusfield ( 1963, 1981) that views the consequences of temperance campaigns, policy initiatives, and social control as primarily symbolic rather than as instrumental in altering human behavior. Both articles view drinking as culturally defined action whose definition changes with time and place as well as with the characteristics of the actors (drinkers and labelers) involved. After summary comments on these two works, attention is turned to placing them in the broader context of the sociology of deviance.Using six years of newspaper editorials and testimony from Parliament, Torronen and Karlsson examine policy changes and the discourse associated with these changes from the context of the "moral regulation" of public space. Editorialists, citizens, politicians, and the police offered competing views of appropriate and inappropriate drinking behavior that changed over time. These constructions, as all interpretations, shift with contingencies: characteristics (youth, wino, middle class) of the drinker; characteristics of the drinking-related behavior (well-behaved, rowdy, offensive); and locale (parks, streets, buses, shopping centers). In viewing these constructions from the context of "moral regulation," the authors call attention to the fact that drinking and drinking-related behavior are being seen as symbolic of other, broader issues, including personal control and freedom, youth and parental responsibility, and the nature of community.Jussi Wacklin examines and compares government actions and policies and police regimes in Leningrad/St. Petersburg and Helsinki that sought to regulate drinking in public establishments (space) in the interwar period. The cities are characterized by relatively similar drinking cultures, practices, and problems. State regulation, temperance movements, and other control practices of different types (police and temperance inspectors, licensing, state regulation of taverns and beer halls, etc.) show some effect on locales of drinking as well as on the environment of drinking establishments, but little, if any, effect on altering consumption patterns and in controlling drinking problems. Wacklin imaginatively uses and interprets historical data (number of beer halls, establishment licenses, and arrest rates for public drunkenness) and combines them with secondary sources to provide a sound basis for his interpretations. Changing social-control policies along with discretionary enforcement practices had differential consequences along social class lines. Additionally, restrictions on public establishments likely encouraged more private drinking as well as a corresponding increase of drinking problems in streets, parks, and other settings.These two articles examine the discourse of citizens and political leaders as well as changes in policy and policing with respect to drinking, drinking-related behavior, and drinking establishments/settings. … | [] | https://semanticscholar.org/paper/161f155fc3872d8a02f66c601727f2d819daa272 | [] | [
{
"name": "David R. Rudy",
"ids": [
"38523801"
]
}
] | [] | [
"1fbcf90afbda1b3bd4328bf99159673d8240c8a6",
"f97a7be0c3dc4a7c0ab49d847c5f72f75084865d"
] | [
"Sociology"
] | 2,005 | Contemporary Drug Problems | 32 | 127 - 130 | [] | 10.1177/009145090503200108 | https://doi.org/10.1177/009145090503200108 | 1718632825 |
|||
29f44ce02d5582fd43dddd69a3ac0ff19b71f7b3 | Hepatitis B virus transmission in a public school: effects of mentally retarded HBsAG carrier students. | In 1980, 18 institutionalized children, carriers of hepatitis B virus (HBV), were enrolled into two special education schools, and staff and students were monitored for HBV markers. Eleven HBV exposures were observed and those exposed were given hepatitis B immune globulin. After 3.5 years, no remaining staff showed serological evidence of HBV infection but three of 61 susceptible students did so. The three students probably acquired the infection outside the school. At the conclusion of the project, one school located in the community decided not to institute a vaccine program for students or staff. The other school, located inside the mental retardation institution, established an organized vaccine initiative. Indications for use of hepatitis vaccine in schools should be individualized to accommodate for differences in student and staff interaction, physical design of the school, and number and behaviors of HBsAg carrier students. | [] | https://semanticscholar.org/paper/29f44ce02d5582fd43dddd69a3ac0ff19b71f7b3 | [] | [
{
"name": "C A Williams",
"ids": [
"145667400"
]
},
{
"name": "F T Weber",
"ids": [
"143916930"
]
},
{
"name": "M McKim",
"ids": [
"7475397"
]
},
{
"name": "C I Steadham",
"ids": [
"12028430"
]
},
{
"name": "M A Kane",
"ids": [
"80257362"
]
}
] | [
"c954694b58a560dfa6f4615698ef233303f6cc53",
"e6378a4f48ba66a82268703da6fe7e44e1035684",
"7dac94b849dafbec5a1a488890e41f5fd58be7cc",
"08655d427aa772ee57702f8a2218888a81aecbfa"
] | [
"ecc831edb31c36a91ac0b9d974b034ae4b61321f",
"d348eb7cfc126b8e49aa17608f06e6b4e08dc8c1",
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"86c47b009ad415e9742eb3df83f42fb320b05f11",
"ff0935e68b184299c5943412230a45d00a7c8ee3",
"cbf8a75383c57181dd01776718aa18925ae2e32a",
"01f3f203489d8ceda64ef8bfcd7f995eddd96d31",
"420a7f276b61c27909699be88058126ed8d6ce33",
"49adf2695a7ec03184c4d949b90e86864e52d5be",
"6c83e070f3936fa894c32cbc0b34beb3ef63d2e6",
"5c8e06a45cf2c251ec1025b80ddcdd42271307b2",
"1851a83949d9c20c032c03f398bcd64fa1b68c0f"
] | [
"Medicine"
] | 1,987 | American journal of public health | American journal of public health | 77 4 |
476-8
| [
"Medline"
] | 10.2105/AJPH.77.4.476 | https://doi.org/10.2105/AJPH.77.4.476 | 3826468 | 2032008807 |
|
ebca9b9c04ae89671e2f16bd7df5dfa7e753093b | Ocean Underwater Scene Dioramas of First Graders with Submarine Porthole Views | Ecology education of the younger generations is vital for worldwide change of people’s attitudes toward nature warranted by the current global ecological crisis. Yet, this goal needs to be addressed through age-appropriate activities that are educational and engaging. This practical article focuses on dioramas of ocean reef life made by first graders. This arts-integrated project served two main purposes: 1) education of primary students about ocean ecology and helping students realize their roles in saving nature 2) increasing student science content knowledge. Additionally, several other benefits of making dioramas emerged during this project, including highly creative student products, genuine interest in the topic of ocean ecology, and heightened levels of motivation and concentration displayed by the students during the project. | [] | https://semanticscholar.org/paper/ebca9b9c04ae89671e2f16bd7df5dfa7e753093b | [
"https://scholarworks.uni.edu/cgi/viewcontent.cgi?article=1049&context=journal-stem-arts"
] | [
{
"name": "Ksenia S. Zhbanova",
"ids": [
"71416153"
]
},
{
"name": "Audrey C. Rule",
"ids": [
"27093502"
]
},
{
"name": "Denise A. Tallakson",
"ids": [
"117326225"
]
}
] | [
"4e17a2dec8a6401ee10d8827e07267679ae953c7"
] | [
"7c48ea3705fcd4477f38704917c1475df54657b7",
"7eb841b68fe6cee84913d375b4d0ca2fc813da16",
"4568b4250499ae1b511984b1ae8fcec716b76662",
"03a473d63a536da24ae7dfb0aedadf891a29f9cb",
"bb610d52d4b766788500c86e480c98d1a64e9589",
"fa338aaa6780e7fb2941ce1ab4437e74d7b516a0",
"100531267d4110c8ca4604782729bf1ec24906ec",
"8eee79eb3f789c6279e2f1017e87626b4ba58285",
"303a36549082f038468ab861e327c2db8f5cfbcb",
"79d1b23354c8c9c84e837a9653a1dfa57dc800a7",
"ae7374b08d41b3db2a15287141a16f3eeb00d553",
"9025e1192908b69b1372878ec29c258effe2f4c4",
"ff149406afa86b4b00044fc95f335beffab5a91d",
"13372fe9ededec6de3dcbd02867bc236513fbfd9",
"4995edee02576157758d73a6ce9490cd25314959",
"617cdf254268bfa3297431c331d58891ac69c457",
"1aa711cd7af77c0edf61007dc3268b21dea7c949",
"5e89bbf20f6ddb7578fc57eae69b495f00d941c3"
] | [
"Engineering"
] | 2,019 | 4 | 4 | [] | 2990810049 |
||||||
cab321895b13999bb42a1bf5788631fce3190538 | [Eukaryotic expression of recombinant B7-H3Ig protein and its effects on T cells]. | OBJECTIVE
To construct a recombinant eukaryotic expression vector containing the human B7-H3Ig gene and investigate the effects of B7-H3 signal on T cells.
METHODS
Being constructed by overlap extension PCR, the recombinant gene fragment of B7-H3Ig was inserted into pGEZ-Term vector. The recombinant pGEZ-Term/B7-H3Ig vector was used to transfect L929 cells to purify B7-H3Ig from conditioned medium harvested from cultured L929/B7-H3Ig cells. T cells were then stimulated with agonistic anti-CD3 mAb in the presence or absence of purified B7-H3Ig, and cell proliferation and the secretion of IL-10 and IFN-γ were analyzed 72 h later.
RESULTS
The concentration of B7-H3Ig was 0.559 mg/mL with a purity of more than 90% after protein G affinity chromatography. B7-H3Ig binding test showed that the putative B7-H3 receptor was presented in activated T cells and the maximum binding capacity was observed 48 h later. B7-H3Ig enhanced, in a dose-dependent manner, the proliferation and IL-10 and IFN-γ secretion of T cells stimulated with agonistic anti-CD3 mAb.
CONCLUSION
L929/B7-H3Ig transfectants have been successfully constructed. B7-H3 is a co-stimulator for T cell proliferation and IL-10 and IFN-γ expressions. | [] | https://semanticscholar.org/paper/cab321895b13999bb42a1bf5788631fce3190538 | [] | [
{
"name": "Liwen Chen",
"ids": [
"37941983"
]
},
{
"name": "Guangbo Zhang",
"ids": [
"2379471"
]
},
{
"name": "Yibei Zhu",
"ids": [
"7995662"
]
},
{
"name": "Xueguang Zhang",
"ids": [
"5725837"
]
}
] | [] | [] | [
"Biology",
"Medicine"
] | 2,013 | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | 29 1 |
27-30
| [
"Medline"
] | 23294715 | 2384099169 |
|||
b289a57fc099fdae1db0350d0c4510a87f32423f | Portable capacitive touch screen testing device | The utility model discloses a portable capacitive touch screen testing device, which comprises a box body. A circuit chamber and a battery chamber are arranged in the box body. A dry battery is arranged in the battery chamber. A test circuit is arranged in the circuit chamber. The front surfaces of the circuit chamber and the battery chamber are fixedly provided with a cover plate. The left side of the cover plate is provided with a plurality of LED indicating lamps. The left sidewall of the box body is fixedly provided with a connecting post. The other end of the connecting post is fixedly provided with a mounting plate. The mounting plate is provided with a plurality of small holes, and metal probes are inserted into the small holes. According to the technical scheme of the utility model, the device is light and practical in integral structure, simple in manufacturing process and low in cost. Due to the adoption of the device, the problem in the prior art that a traditional testing device is difficult to carry about and high in cost can be solved. Meanwhile, the device is free from being limited by the field and the power failure and is provided with the probes for realizing the detection. Therefore, the device is quick and convenient to use and high in efficiency. | [] | https://semanticscholar.org/paper/b289a57fc099fdae1db0350d0c4510a87f32423f | [] | [
{
"name": "李建宏",
"ids": [
"52362852"
]
}
] | [] | [] | [
"Computer Science"
] | 2,013 | [] | 2940043270 |
||||||||
a1eeee966267d9b036029976406d199daef76f17 | The Diffusion Kernel Filter | A particle filter method is presented for the discrete-time filtering problem with nonlinear Itô stochastic ordinary differential equations (SODE) with additive noise supposed to be analytically integrable as a function of the underlying vector-Wiener process and time. The Diffusion Kernel Filter is arrived at by a parametrization of small noise-driven state fluctuations within branches of prediction and a local use of this parametrization in the Bootstrap Filter. The method applies for small noise and short prediction steps. With explicit numerical integrators, the operations count in the Diffusion Kernel Filter is shown to be smaller than in the Bootstrap Filter whenever the initial state for the prediction step has sufficiently few moments. The established parametrization is a dual-formula for the analysis of sensitivity to gaussian-initial perturbations and the analysis of sensitivity to noise-perturbations, in deterministic models, showing in particular how the stability of a deterministic dynamics is modeled by noise on short times and how the diffusion matrix of an SODE should be modeled (i.e. defined) for a gaussian-initial deterministic problem to be cast into an SODE problem. From it, a novel definition of prediction may be proposed that coincides with the deterministic path within the branch of prediction whose information entropy at the end of the prediction step is closest to the average information entropy over all branches. Tests are made with the Lorenz-63 equations, showing good results both for the filter and the definition of prediction. | [] | https://semanticscholar.org/paper/a1eeee966267d9b036029976406d199daef76f17 | [
"http://www.physics.arizona.edu/~tolwinski/Slides/Krause.pdf"
] | [
{
"name": "Paul Krause",
"ids": [
"143930742"
]
}
] | [
"a06005b5cc811c3bd1368b2272b93abf68296fc8",
"760040c68123374687da39362f5b1588eb94071f"
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] | [
"Mathematics"
] | 2,009 | Journal of Statistical Physics | 134 | 365-380 | [] | 10.1007/S10955-008-9673-1 | https://doi.org/10.1007/S10955-008-9673-1 | 2091143251 |
|||
3feee9c5e57f6775542e682158d2e5259563fd63 | A study on separation performance of a vortex finder in a liquid-liquid cylindrical cyclone | This paper outlines the influence of design parameters such as different diameter, different shapes and insertion depth of a vortex finder on Liquid-Liquid Cylindrical Cyclone (LLCC) oil-water separation characteristics through experiments and numerical simulations. Through numerical simulations, the separation efficiency for water-dominated flow conditions is obtained and the results show that there exists an optimal shape, diameter and insertion depth of a vortex finder in cylindrical cyclones under certain conditions. In our laboratory, a 100mm inner diameter LLCC is adopted to test the influence of different insertion depths of the vortex finder and the results again indicate that an optimal insertion depth exists. The numerical results agree well with the experimental data of Rajkumar S et al.. So numerical simulations can be used to predict the complex flow behavior, the separation efficiency in a LLCC for optimizing the structure and provide some design guidance for their industrial application as the oil-water separators on offshore platforms and oil field inland. | [] | https://semanticscholar.org/paper/3feee9c5e57f6775542e682158d2e5259563fd63 | [
"http://dspace.imech.ac.cn/bitstream/311007/58602/1/JourArSuppl2016-037.pdf"
] | [
{
"name": "Shiying Shi",
"ids": [
"2464748"
]
},
{
"name": "Yingxiang Wu",
"ids": [
"102855601"
]
},
{
"name": "Jun Zhang",
"ids": [
"50562248"
]
},
{
"name": "Jun Guo",
"ids": [
"40177149"
]
},
{
"name": "Shu-jing Wang",
"ids": [
"49184751"
]
}
] | [
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] | [
"Materials Science"
] | 2,010 | Journal of Hydrodynamics | 22 | 380-386 | [] | 10.1016/S1001-6058(09)60225-0 | https://doi.org/10.1016/S1001-6058%2809%2960225-0 | 2262511797 |
|||
0a65aae158e63c07af4347102fab004ef2e4d7c9 | Changes in regional cerebral metabolism during systemic hyperthermia in humans. | Whole body hyperthermia may produce vasodialation, nausea, and altered cognitive function. Animal research has identified brain regions that have important roles in thermoregulation. However, differences in both the cognitive and sweating abilities of humans and animals implicate the need for human research. Positron emission tomography (PET) was used to identify brain regions with altered activity during systemic hyperthermia. Human subjects were studied under cool (control) conditions and during steady-state hyperthermia induced by means of a liquid-conditioned suit perfused with hot water. PET images were obtained by injecting [(18)F]fluorodeoxyglucose, waiting 20 min for brain uptake, and then scanning for 10 min. Heating was associated with a 23% increase in resting metabolic rate. Significant increases in cerebral metabolic rate occurred in the hypothalamus, thalamus, corpus callosum, cingulate gyrus, and cerebellum. In contrast, significant decreases occurred in the caudate, putamen, insula, and posterior cingulum. These results are important for understanding the mechanisms responsible for altered cognitive and systemic responses during hyperthermia. Novel regions (e.g., lateral cerebellum) with possible thermoregulatory roles were identified. | [] | https://semanticscholar.org/paper/0a65aae158e63c07af4347102fab004ef2e4d7c9 | [
"http://jap.physiology.org/content/jap/early/2001/10/26/japplphysiol.00072.2001.full.pdf",
"http://jap.physiology.org/content/jap/92/2/846.full.pdf",
"http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=AB8739D5D98EAFC0A605AC5A92504D4B?doi=10.1.1.327.7958&rep=rep1&type=pdf",
"http://jap.physiology.org/content/early/2001/10/26/japplphysiol.00072.2001.full.pdf"
] | [
{
"name": "Sarah A Nunneley",
"ids": [
"6374606"
]
},
{
"name": "Charles C Martin",
"ids": [
"144539608"
]
},
{
"name": "James W Slauson",
"ids": [
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]
},
{
"name": "Christopher M Hearon",
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"3853747"
]
},
{
"name": "Lisa D H Nickerson",
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"2185812"
]
},
{
"name": "Patrick A Mason",
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"144011974"
]
}
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] | [
"Medicine",
"Chemistry"
] | 2,002 | Journal of applied physiology | Journal of applied physiology | 92 2 |
846-51
| [
"Medline"
] | 10.1152/JAPPLPHYSIOL.00072.2001 | https://doi.org/10.1152/JAPPLPHYSIOL.00072.2001 | 11796700 | 2164005217 |
|
ab575c3b65a7fc58f0f4cf30876d6062e3b34a3f | Steam and Hydrogen Conversions of Hydroxy-, Chloro-, and Nitro-Toluenes on Metal Catalysts | Abstract The effect of functional groups (OH, CI, NO2) on the reactivity in steam or hydrogen of the C-C bonds of aromatic compounds was studied in the case of metallic catalysts (Rh, Ni, Pd) so as to eliminate selectively either the alkyl group or the second substituent. In cresol steam conversion, rhodium is the most active metal whereas palladium is the most selective for the dealkylation. For the three metals the OH group increases the C-C bond reactivity in the aromatic nucleus. Cresol compared to toluene is more reactive in steam than in hydrogen. In conversions of chloro- and nitrotoluene, the reactions involving the functional groups (dechlorination and reduction of the nitro group) are very fast. The activity in dealkylation is not modified by the functional groups. This is not the case for the ring gasification reactions which are more significant than with toluene. | [] | https://semanticscholar.org/paper/ab575c3b65a7fc58f0f4cf30876d6062e3b34a3f | [] | [
{
"name": "Daniel Duprez",
"ids": [
"50188149"
]
},
{
"name": "M. Assafi",
"ids": [
"91297437"
]
}
] | [] | [
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"76a7fce5a95e3b7785b3a3869fc0e35b1f93a83c"
] | [
"Chemistry"
] | 1,988 | Studies in Surface Science and Catalysis | 41 | 179-187 | [] | 10.1016/S0167-2991(09)60813-2 | https://doi.org/10.1016/S0167-2991%2809%2960813-2 | 124974595 |
|||
c0a20da5d22504b12bdb17222f42617781fd6437 | Solid-state transformations of zinc 1,4-benzenedicarboxylates mediated by hydrogen-bond-forming molecules. | The zinc 1,4-benzenedicarboxylates [Zn3(bdc)3(H2O)3] . 4 DMF (1; bdc = 1,4-benzenedicarboxylate), [Zn(bdc)(H2O)] . DMF (2), and [Zn(bdc)] DMF (3) crystallise at room temperature from mixtures of toluene/ dimethylformamide (DMF) under concentrated, dilute and dry conditions, respectively. The structure of phase 1 (monoclinic: P2(1)/c, a 13.065(1), b = 9.661(1), c = 18.456(1) A, beta = 106.868(2) degrees) consists of layers containing stacks of three zinc cations linked by mono- and bidentate bdc groups. Structure 1 converts to the known phase 2 by an irreversible, reconstructive phase transformation, whereas 2 and 3 interconvert reversibly upon the loss or addition of water. Removal of all solvent molecules included during crystallisation gives poorly crystalline [Zn(bdc)] (4), which is readily converted to highly crystalline solids upon contact with hydrogen-bond-forming molecules such as water, DMF and small alcohols. The crystal structures of the mono- and dihydrates [Zn(bdc)(H2O)] (6) and [Zn(bdc)-(H2O)2] (7) have been determined ab initio from powder X-ray diffraction data (compound 6, monoclinic: C2/c, a = 17.979(1), b = 6.352(1), c = 7.257(1) A, beta=91.477(1) compound 7, monoclinic: C2/c, a = 14.992(1), b = 5.0303(2), c = 12.098(1) A, beta = 103.82(1) degrees). The methanol adduct [Zn3(bdc)3] . 6CH3OH (5) is the same as that prepared previously by direct crystallisation. Comparison of these adduct structures with those prepared directly reveal that they are formed by in situ recrystallisations. Subsequent removal of included molecules gives amorphous [Zn(bdc)], which can be recrystallised again when placed in contact with hydrogen-bond-forming molecules. | [] | https://semanticscholar.org/paper/c0a20da5d22504b12bdb17222f42617781fd6437 | [] | [
{
"name": "M Edgar",
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]
},
{
"name": "R Mitchell",
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},
{
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"name": "P Lightfoot",
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]
},
{
"name": "P A Wright",
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] | [
"Medicine",
"Chemistry"
] | 2,001 | Chemistry | Chemistry | 7 23 |
5168-75
| [
"Medline"
] | 10.1002/1521-3765(20011203)7:23<5168::AID-CHEM5168>3.0.CO;2-S | https://doi.org/10.1002/1521-3765%2820011203%297%3A23%3C5168%3A%3AAID-CHEM5168%3E3.0.CO%3B2-S | 11775690 | 2026076528 |
|
8a2d4f58471d31139a1d11f3ee6ee0697b67aa85 | Are experimental smokers different from their never-smoking classmates? A multilevel analysis of Canadian youth in grades 9 to 12. | INTRODUCTION
Understanding the characteristics of experimental smoking among youth is critical for designing prevention programs. This study examined which student- and school-level factors differentiated experimental smokers from never smokers in a nationally representative sample of Canadian students in grades 9 to 12.
METHODS
School-level data from the 2006 Canadian Census and one built environment characteristic (tobacco retailer density) were linked with data from secondary school students from the 2008-2009 Canadian Youth Smoking Survey and examined using multilevel logistic regression analyses.
RESULTS
Experimental smoking rates varied across schools (p < .001). The location (adjusted odds ratio [AOR] = 0.66, 95% CI: 0.49-0.89) of the school (urban vs. rural) was associated with the odds of a student being an experimental smoker versus a never smoker when adjusting for student characteristics. Students were more likely to be experimental smokers if they were in a lower grade, reported low school connectedness, used alcohol or marijuana, believed that smoking can help people relax, received pocket money each week and had a family member or close friend who smoked cigarettes.
CONCLUSION
School-based tobacco prevention programs need to be grade-sensitive and comprehensive in scope; include strategies that can increase students' attachment to their school; and address multi-substance use, tobacco-related beliefs and the use of pocket money. These programs should also reach out to students who have smoking friends and family members. Schools located in rural settings may require additional resources. | [] | https://semanticscholar.org/paper/8a2d4f58471d31139a1d11f3ee6ee0697b67aa85 | [
"http://discoveryspace.upei.ca/cshr/sites/discoveryspace.upei.ca.cshr/files/CDIC_MCC_Vol34_2-3_07_Kaai-eng.pdf",
"http://www.phac-aspc.gc.ca/publicat/hpcdp-pspmc/34-2-3/assets/pdf/CDIC_MCC_Vol34_2-3_07_Kaai-eng.pdf"
] | [
{
"name": "S C Kaai",
"ids": [
"10379667"
]
},
{
"name": "S R Manske",
"ids": [
"4511740"
]
},
{
"name": "S T Leatherdale",
"ids": [
"5150189"
]
},
{
"name": "K S Brown",
"ids": [
"144375838"
]
},
{
"name": "D Murnaghan",
"ids": [
"16557214"
]
}
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] | [
"Medicine"
] | 2,014 | Chronic diseases and injuries in Canada | Chronic diseases and injuries in Canada | 34 2-3 |
121-31
| [
"Medline"
] | 10.24095/HPCDP.34.2/3.07 | https://doi.org/10.24095/HPCDP.34.2%2F3.07 | 24991775 | 1768955800 |
|
300f0ceabe1cc76fa1348aad318a2beca5415d07 | Comovements of Budget Deficits, Exchange Rates, and Outputs of Traded and Non-traded Goods | Between 1974:1-1989:2, it appears that U.S. budget deficits and real exchange rates are correlated. This paper attempts to provide a structural explanation of these comovements in government budget deficits and exchange rates. The model expands on previous wo rks to include fiscal policy considerations in a stochastic set-up. It shows that within a simple two-country cash-in-advance constraint model, it is possible to have a positive correlation between budget deficits and exchange rates, as well as a negative correlation betwe en exchange rates and domestic traded goods production. Copyright 1993 by Oxford University Press. | [] | https://semanticscholar.org/paper/300f0ceabe1cc76fa1348aad318a2beca5415d07 | [] | [
{
"name": "Ashraf Nakibullah",
"ids": [
"12201322"
]
}
] | [
"a5014498679274fe081e17f97bdec6809ca9d314",
"a0d7bf4bb399486ba9bec46a4ad4c92364cd1935",
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] | [
"b0457ee696c9c0509b8b3e9349dca72464847e0a",
"80a6b0d90eb4dfe484e607b92b45502f23efc371",
"90555ca543310b73dc186b60424855fa73bcb84b",
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"74ddbb68114512f30dddc41f2c98cfbf739a4a61",
"f6d35787d68e4e15646adca4dc24543a84ca8d05"
] | [
"Economics"
] | 1,993 | Economic Inquiry | 31 | 298-313 | [] | 10.1111/J.1465-7295.1993.TB00884.X | https://doi.org/10.1111/J.1465-7295.1993.TB00884.X | 2034689630 |
|||
272e6ab1c5c5bee8e1d141b68771a4733ba35d48 | Limit-feeding corn as an alternative to hay reduces manure and nutrient output by Holstein cows. | Efficiency of limit-feeding a whole shelled corn-based diet as an alternative to a conventional forage-based diet for nonlactating dairy cattle was determined. Twelve nonlactating, multiparous Holstein cows (initial BW 642+/-50 kg) were used in a randomized complete block design. Nutrient digestibility, excretion of DM, N, and P, performance of cows, and feed costs were measured. Both diets were formulated to provide equal daily intakes of NE1, protein, vitamins, and minerals, according to National Research Council recommendations. Dry matter intake was restricted by 30% for cows fed the high-corn diet compared with the high-forage diet (6.8 vs 9.6 kg/ d, respectively); therefore, concentrations of nutrients in the high-corn diet were increased to compensate for decreased DMI. Diets were fed once daily, and cows had unlimited access to fresh water. After a 28-d adaptation period, cows were placed in metabolism stalls for a 6-d total collection of feces and urine. The limit-fed, high-corn diet had a 15% greater DM digestibility than the high-forage diet. A 29% decrease in DMI for the high-corn diet vs the high-forage diet resulted in a 40% decrease in fecal DM excretion. Starch digestibility and digestibility of whole corn kernels were not affected (P > or = .62) by diet. Despite similar N intakes, total N excretion was 22% greater (P < .01) for cows fed the high-forage diet than for those limit-fed the high-grain diet. Cow weight and condition score change did not differ (P > .10) between diets. Feed costs were reduced by $.38/d with the high-corn diet vs the high-forage diet. Limit-feeding a corn-based diet is an economically and nutritionally viable alternative to forage-based diets for nonlactating Holstein cows. | [] | https://semanticscholar.org/paper/272e6ab1c5c5bee8e1d141b68771a4733ba35d48 | [] | [
{
"name": "L J Driedger",
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]
},
{
"name": "S C Loerch",
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]
}
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"70ae67ec12d13d6352b7e5e5582c018ad527899c",
"b172c2628dee9093e5066aa451120c064a824cfe",
"0e461b34a5531b84bcd96c056738a26be11c9255",
"63ca969fb1fdcdc3a7f6a6766c217647e89df54c",
"a9fade3c6b7acbcbe2577ffbae19fcec96cceef2",
"53b828c1c4e0d7e79c1584c15fe1ae542d1d7bae",
"3c7f91c8b3ef72242b97101696c9210e4d53797b",
"b0d0bc7dc6f986183714c144eac0e9c3ca4ac25f"
] | [] | [
"Medicine",
"Biology"
] | 1,999 | Journal of animal science | Journal of animal science | 77 4 |
967-72
| [
"Medline"
] | 10.2527/1999.774967X | https://doi.org/10.2527/1999.774967X | 10328364 | 2417155491 |
|
5aef0b8e9a94b134e15fc7173c0a4490b6cbb64b | Two Cases of Papillon-Lef $\'{e}$ vre Syndrome | Papillon-Lefvre syndrome is an extremely rare genodermatosis characterized by palmoplantar keratoderma and premature loss of teeth. It is inherited as an autosomal recessive trait, and is known to be caused by a loss-of-function mutation in the cathepsin C gene. Mutations of this gene may result in epithelial defects producing keratoderma and secondary periodontitis recalcitrant to traditional treatment, causing subsequent premature loss of teeth. In addition, patients may have increased susceptibility to infection. Histopathologic features are nonspecific, so diagnosis has been made through characteristic skin and teeth findings in many reported cases. Oral retinoids are the mainstay of treatment, but the safety of oral retinoids in children remains controversial due to their side effects in skeletal development. Therefore, a multidisciplinary approach is important for the care of patients with this syndrome. We present two cases of Papillon-Lefvre syndrome. To our knowledge, this condition has not been reported previously in the Korean dermatologic literature. | [] | https://semanticscholar.org/paper/5aef0b8e9a94b134e15fc7173c0a4490b6cbb64b | [] | [
{
"name": "Hyun-Ho Cho",
"ids": [
"145076850"
]
},
{
"name": "Su-Han Kim",
"ids": [
"4188881"
]
},
{
"name": "Sang-Hee Seo",
"ids": [
"4186739"
]
},
{
"name": "Do-Sang Jung",
"ids": [
"3694571"
]
},
{
"name": "Hyun-Chang Ko",
"ids": [
"144206534"
]
},
{
"name": "Moon-Bum Kim",
"ids": [
"39991245"
]
},
{
"name": "Kyung-Sool Kwon",
"ids": [
"66816126"
]
}
] | [] | [] | [
"Medicine"
] | 2,009 | Journal of Clinical Dermatology | 47 | 472-478 | [] | 2376995915 |
|||||
d212fbbc35286ad1c6d29f663e6015c7d15bec66 | Crystal structure of di-μ-amido-bis[diammineplatinum(II)] nitrate | Di-μ-amido-bis[diammineplatinum(II)] nitrate (1) was synthesized as a byproduct during preparation of tetraammineplatinum(II) nitrate. One possible pathway to produce 1 is that [(H3N)2Pt(μ- OH)2Pt(NH3)2](NO3)2, a well-known complex forming on treatment of cis-Pt(NH3)2I2 with AgNO3, reacts with aqueous ammonia. The other possible pathway involves deprotonation of [Pt(NH3)4](NO3)2 to form monomeric Pt(NH3)3(NH2)NO3 followed by elimination of NH3. Crystals of 1 (from water) are monoclinic (C2/c) with a = 16.834(2) Å, b = 10.573(1) Å, c = 7.415(1) Å, β = 114.846(1)°, and Z = 4. The cationic portion consists of two symmetrical square-planar Pt centers with the inversion center at the midpoint of the Pt(1)∙∙∙Pt(1A) vector. The Pt(II) ion is coordinated by four N atoms from two ammonia molecules and two bridging amido groups affording a slightly distorted square. The molecules are stacked in such a way that the planes of coordination squares turn out to be parallel to each other with a distance of 3.501 Å. Intermolecular Pt–H interaction between the μ-NH2 hydrogens and the platinum(II) centers of the adjacent molecule are observed. | [] | https://semanticscholar.org/paper/d212fbbc35286ad1c6d29f663e6015c7d15bec66 | [] | [
{
"name": "Qingsong Ye",
"ids": [
"39985665"
]
},
{
"name": "Ming-Jin Xie",
"ids": [
"5043741"
]
},
{
"name": "Xiao-Nian Li",
"ids": [
"5070573"
]
},
{
"name": "W.-P. Liu",
"ids": [
"21618923"
]
},
{
"name": "J. Yu",
"ids": [
"11305907"
]
},
{
"name": "Qiao-Wen Chang",
"ids": [
"70606534"
]
},
{
"name": "J. Jiang",
"ids": [
"79504040"
]
},
{
"name": "C.-X. Yan",
"ids": [
"32845173"
]
},
{
"name": "J. Li",
"ids": [
"49298001"
]
}
] | [] | [
"729ec89b72fa9f440975c8121e7222ca5406fb73",
"98ba69e3d0e12d5c8bc37077a190da98572d4bea",
"802b625fed5070cbeda7ad676be37792e50facbf",
"60b9794d347900a6d22106462106d9ed20bd8b02",
"0ebc6f952d50eb28ecfff8c4a5fdb1bfbd41f1a5",
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"f2f39b9b23af33989352e52112d5c88650ed2312",
"af32d7a978dc6e33e8beb4086c85160f1927d87b",
"e72d48058c7152598c4755b4212e59b5cf132d9f",
"8da4658142d529ef49cdcde03dceb6e0f0766fb3",
"93abb1e3c116c7eeea68fd31aa38992904918a92",
"6e5c57d0936d562c34afed13e13b820651555438",
"a3a29eba4032e17af0628af106d091fdc5386a33",
"7722beaef42b593614c33373d5abf2c6811fd317",
"cfa1429c3221f01cbe6cc2c764f343cf9690b656"
] | [
"Chemistry"
] | 2,016 | Journal of Structural Chemistry | Journal of Structural Chemistry | 57 | 845-848 | [] | 10.1134/S0022476616040351 | https://doi.org/10.1134/S0022476616040351 | 2524890555 |
||
a860515fa57465918ed73bc0131470133d712d4e | Membranes and Their Appplication in Industry | Potential and limits of pressure driven membrane separation processes are discussed with
respect to the application in industrial separations.Based on membrane separation conferences held in 1998 the present state of the art is described and information about new achievements presented. Low presure RO membranes, enhanced shear rate modules (centrifugal, vibratory), direct filtration NF modules for potable water production, DT and CD modules eliminating retentate spacer and some latest developments in NF ceramic membranes are discussed. Four industrial applications are described in detail. | [] | https://semanticscholar.org/paper/a860515fa57465918ed73bc0131470133d712d4e | [] | [
{
"name": "J. Pridal",
"ids": [
"92537989"
]
}
] | [] | [] | [
"Chemistry"
] | 1,999 | Chemicke Listy | 93 | [] | 2808271879 |
||||||
44e8cdaf243179d41e3d1772ba396c29f8f4b7c9 | Directed evolution of adeno-associated virus for glioma cell transduction | Glioblastoma multiforme (GBM) is a serious form of brain cancer for which there is currently no effective treatment. Alternative strategies such as adeno-associated virus (AAV) vector mediated-genetic modification of brain tumor cells with genes encoding anti-tumor proteins have shown promising results in preclinical models of GBM, although the transduction efficiency of these tumors is often low. As higher transduction efficiency of tumor cells should lead to enhanced therapeutic efficacy, a means to rapidly engineer AAV vectors with improved transduction efficiency for individual tumors is an attractive strategy. Here we tested the possibility of identifying high-efficiency AAV vectors for human U87 glioma cells by selection in culture of a newly constructed chimeric AAV capsid library generated by DNA shuffling of six different AAV cap genes (AAV1, AAV2, AAV5, AAVrh.8, AAV9, AAVrh.10). After seven rounds of selection, we obtained a chimeric AAV capsid that transduces U87 cells at high efficiency (97% at a dose of 104 genome copies/cell), and at low doses it was 1.45–1.6-fold better than AAV2, which proved to be the most efficient parental capsid. Interestingly, the new AAV capsid displayed robust gene delivery properties to all glioma cells tested (including primary glioma cells) with relative fluorescence indices ranging from 1- to 14-fold higher than AAV2. The selected vector should be useful for in vitro glioma research when efficient transduction of several cell lines is required, and provides proof-of-concept that an AAV library can be used to generate AAV vectors with enhanced transduction efficiency of glioma cells. | [] | https://semanticscholar.org/paper/44e8cdaf243179d41e3d1772ba396c29f8f4b7c9 | [] | [
{
"name": "Casey A. Maguire",
"ids": [
"12605892"
]
},
{
"name": "Davide Gianni",
"ids": [
"3926170"
]
},
{
"name": "Dimphna H. Meijer",
"ids": [
"48623162"
]
},
{
"name": "Lev A. Shaket",
"ids": [
"5149416"
]
},
{
"name": "Hiroaki Wakimoto",
"ids": [
"34972222"
]
},
{
"name": "Samuel D. Rabkin",
"ids": [
"3699020"
]
},
{
"name": "Guangping Gao",
"ids": [
"144472231"
]
},
{
"name": "Miguel Sena-Esteves",
"ids": [
"1398645971"
]
}
] | [
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"16b9dad1306b3e458c911eae172bde9fd6e62d05",
"00d01f599399772d38a9b8a602ac7bc079121820",
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"fbacda8dc197b08a39c0465860c38a690619ea25",
"d42e573a2bbb1ab43f362aa3ba3f7bef19da9cbb",
"97c1ed4f407c9c05c29d6d3bb34c602841e2b059",
"82a3c73d9feb953e78579d17f3e6fe20b1e85e5d",
"51f9755a30d264d3ddb812ddd2f0a590260ba294",
"aa72e5336b370a051782ba5e7f1a67970286f096",
"dfbc166d62435027cf5a32d948ba50f14f76fb17",
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"01e911da375178168f24964cf71404dcdc58e93f",
"9a5908372e321182cd9d16f0583b19651ec98019"
] | [
"Biology",
"Medicine"
] | 2,009 | Journal of Neuro-Oncology | Journal of Neuro-Oncology | 96 | 337-347 | [
"Medline"
] | 10.1007/s11060-009-9972-7 | https://doi.org/10.1007/s11060-009-9972-7 | 19618115 | 2154772938 |
|
699badccf33b47c5e19a9a9b9528d3cdd3e52e47 | Metal Biomonitoring and Comparative Assessment in Urine of Workers in Lead-Zinc and Steel-Iron Mining and Smelting | The exposure of heavy metals (lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), and metalloid arsenicals) and their effects on workers’ health from a lead-zinc mine (145 workers) and a steel smelting plant (162 workers) was investigated. Information on subject characteristics was obtained through a questionnaire. We determined the urinary levels of Pb, Cd, Cu, Ni, and arsenicals (including inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), as were 8-hydroxydeoxyguanosine (8-OHdG) and cystatin C. Lead-zinc mine foundry workers had significantly higher concentrations of urinary Pb, Cd, Cu, Ni, iAs, and MMA than did steel smelting plant workers. Individuals who had consumed seafood in the previous 3 days had higher concentrations of urinary Ni than did individuals who had not consumed seafood. The urinary Cd concentrations in the two groups of factory workers may have been affected by daily smoking. There was no significant difference in urinary 8-OHdG between workers from the lead-zinc mine foundry and the steel smelting plant. Urinary Pb and Cd had significant positive linear dose-dependent effects on 8-OHdG. Urinary cystatin C, a sensitive biological indicator reflecting early renal damage, was found at higher levels in lead-zinc mine workers than in steel smelting plant workers. Binary logistic regression analysis showed that age and urinary Cd were significantly associated with urinary cystatin C. These results indicated that workers from lead-zinc mines may be exposed to higher levels of heavy metals which could lead to greater risk of kidney damage. | [] | https://semanticscholar.org/paper/699badccf33b47c5e19a9a9b9528d3cdd3e52e47 | [] | [
{
"name": "Xiaoyan Wang",
"ids": [
"38760027"
]
},
{
"name": "Peiyu Jin",
"ids": [
"23204229"
]
},
{
"name": "Qing Zhou",
"ids": [
"144625433"
]
},
{
"name": "Shengnan Liu",
"ids": [
"2396927"
]
},
{
"name": "Fei Wang",
"ids": [
"1682816"
]
},
{
"name": "Shuhua Xi",
"ids": [
"37912281"
]
}
] | [
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"a48fa03e44ff62613ee00c931d37cb876d6d72ce",
"6a913aaf57065b2cb887c712b6821cb2de9df31b",
"54affcab78947c608effec13d46b358dcc791117",
"c4a38d29aa5e8c223f71919dabf4fb9ca32e0908",
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"651c1b112ea7e1309688720db3fda52ae3f7b02d",
"548231253b97aa4f9b84845a248c3cf401747c3f"
] | [
"Chemistry",
"Medicine"
] | 2,018 | Biological Trace Element Research | Biological Trace Element Research | 189 | 1-9 | [
"Medline"
] | 10.1007/s12011-018-1449-0 | https://doi.org/10.1007/s12011-018-1449-0 | 30054879 | 2884583472 |
|
2aafcd03721e66b2d0066c85def5a70a3ee8df42 | Introducing an Optimal Liver Allocation System for Liver Cirrhosis Patients | Background Liver transplantation (LT) is the only treatment option for patients with advanced liver disease. Currently, liver donation to these patients, considering priorities, is based on the Model for End-Stage Liver Disease (MELD). MELD score is a tool for predicting the risk of mortality in patients with advanced liver disease. However, few studies have so far been conducted in Iran on the efficacy of MELD score of these patients. Objectives This study reviews the present status of the MELD score and introduces a new model for optimal prediction of the risk of mortality in Iranian patients with advanced liver disease. Patients and Methods Data required were collected from 305 patients with advanced liver disease who enrolled in a waiting list (WL) in Imam Khomeini Hospital from May 2008 to May 2009. All of the patients were followed up for at least 3 years until they died or underwent LT. Cox regression analysis was applied to select the factors affecting their mortality. Survival curves were plotted. Wilcoxson test and receiver operating characteristics curves for survival predictive model were used to compare the scores. All calculations were performed with the SPSS (version 13.0) and R softwares. Results During the study, 71 (23.3%) patients died due to liver cirrhosis and 43 (14.1%) underwent LT. Viral Hepatitis (43.7%) is the most common cause of end-stage liver disease among Iranian patients. A new model (NMELD) was proposed with the use of the natural logarithms of two blood serum variables (total bilirubin and albumin) and the patients' age (year) by applying the Cox model: NMELD = 10 × (0.736 × ln (bilirubin) – 1.312 × ln (albumin) + 0.025 × age + 1.776) Conclusions The results of the Wilcoxon test showed that there is a significant difference between the usual MELD and our proposed NMELD scores (P < 0.001). Receiver operating characteristics curve for survival predictive model indicated that the NMELD score is more efficient compared with the MELD score in predicting the risk of mortality. Since serum creatinine was not significant in NMELD score, further studies to clarify this issue are suggested. | [] | https://semanticscholar.org/paper/2aafcd03721e66b2d0066c85def5a70a3ee8df42 | [] | [
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