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adenohypophysial prolactin of lactating rats was pulse-labelled by [ 3h ] leucine injected i.v . at the time of removal of the pups . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysial",
"pos": [
0,
16
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
17,
26
]
} |
hypothalamic lhrh content was significantly elevated in short-photoperiod animals , but within 24 hr of transfer to a 14:10 photoperiod , lhrh declined to levels not different from those in hamsters maintained continuously in a long photoperiod . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
138,
142
]
} |
two hundred one deaf adolescents with congenital rubella syndrome and 83 age-matched deaf control subjects were evaluated for the presence of organ-specific antibodies directed against thyroid microsomes , thyroglobulin , pancreatic islets , adrenal cortex , and gastric parietal cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
185,
192
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
206,
219
]
} |
chronic administration of net but not progesterone to castrated animals induced a significant decrease of plasma and pituitary lh with a concomitant replenishment of hypothalamic gnrh in an identical fashion to that observed with chronic administration of 17 beta-estradiol . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
166,
178
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
179,
183
]
} |
such a relatively high t3 content in the secretion of the thyroid could be caused by a low t4/t3 ratio in thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
58,
65
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
106,
119
]
} |
answers to these questions have come from studies in normal and regenerating liver of , a ) the proportion of non-repetitive and repetitive dna transcribed , b ) the complexity of mrna populations and the abundance of sequences in these populations , c ) the extent of homology between mrna populations , d ) the amounts of specific mrnas for albumin , alphafetoprotein , and fibrinogen , and e ) the transcription of some cellular oncogenes . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
77,
82
]
} | {
"id": "C0002210",
"name": "alphafetoprotein",
"pos": [
353,
369
]
} |
the endothelial cell is a rich source of plasminogen activator that is associated with fibrinolytic activity in blood vessel . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cell",
"pos": [
4,
20
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
41,
62
]
} |
following 35 days of storage , units of red cells prepared from whole blood drawn into cpda-1 and cpda-2 had comparable plasma cation and ammonia levels and similar amounts of cell-free hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
40,
49
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
186,
196
]
} |
the benign clinical course supports the hypothesis that red cell antigen-antibody complexes , rather than free hemoglobin or red cell stroma , are responsible for the life-threatening complications of acute hemolytic transfusion reactions . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
56,
64
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
111,
121
]
} |
the effects of ocusert pilocarpine on anterior chamber depth , visual acuity and intraocular pressure in man . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
15,
22
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
23,
34
]
} |
the duration of intraocular pressure reduction by ocusert pilocarpine was found to be 10 days for p20 and 12 days for p40 . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
50,
57
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
58,
69
]
} |
ocusert pilocarpine reduced visual acuity and anterior chamber depth less than the aqueous pilocarpine drops . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
0,
7
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
91,
102
]
} |
[ research on the action of lioresal ( baclofen ) and diazepam ( valium ) in neurogenic spasmophilia ( using an original method of polygraphic recording ) ] . | tradename_of | {
"id": "C0699999",
"name": "lioresal",
"pos": [
28,
36
]
} | {
"id": "C0004609",
"name": "baclofen",
"pos": [
39,
47
]
} |
a double-blind crossover comparison of orudis ( ketoprofen ) and indomethacin in the treatment of rheumatoid arthritis . | tradename_of | {
"id": "C0700190",
"name": "orudis",
"pos": [
39,
45
]
} | {
"id": "C0022635",
"name": "ketoprofen",
"pos": [
48,
58
]
} |
a follow-up survey of 908 women who had received 'premarin ' ( conjugated equine oestrogen ) for menopausal symptoms revealed 8 cases of ovarian cancer . | tradename_of | {
"id": "C0699710",
"name": "premarin",
"pos": [
50,
58
]
} | {
"id": "C0014938",
"name": "conjugated",
"pos": [
63,
73
]
} |
the ocusert , a long-acting pilocarpine-incorporated ocular insert , is a recent advance in delivery technique that offers an adequate hypotensive action with fewer side effects . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
4,
11
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
28,
39
]
} |
eight hundred twenty-four patients who had cardiac valve replacement with a porcine bioprosthesis were given either coumadin ( sodium warfarin ) or aspirin . | tradename_of | {
"id": "C0699129",
"name": "coumadin",
"pos": [
116,
124
]
} | {
"id": "C0376218",
"name": "sodium warfarin",
"pos": [
127,
142
]
} |
22 adult females with therapy-resistant acne vulgaris were treated for 12 months with diane , a drug containing cyproterone acetate and ethinylestradiol . | tradename_of | {
"id": "C0057721",
"name": "diane",
"pos": [
86,
91
]
} | {
"id": "C0056855",
"name": "cyproterone acetate",
"pos": [
112,
131
]
} |
two studies assessed ( 1 ) the effect of medroxyprogesterone acetate ( mpa ) , depo-provera , on socio-sexual behaviors , and ( 2 ) the interaction between socio-environmental conditions and mpa treatment effects . | tradename_of | {
"id": "C0699700",
"name": "depo-provera",
"pos": [
79,
91
]
} | {
"id": "C0065864",
"name": "mpa",
"pos": [
191,
194
]
} |
in 2 infants who had received intralipid fat emulsion as part of a total parenteral hyperalimentation regimen , a pigmented material was deposited in the macrophages of their reticuloendothelial systems . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
30,
40
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
41,
53
]
} |
periactin ( cyproheptadine hydrochloride ) as a supplement to the immunosuppressive treatment in human cadaver kidney transplantation . | tradename_of | {
"id": "C0031017",
"name": "periactin",
"pos": [
0,
9
]
} | {
"id": "C0354872",
"name": "cyproheptadine hydrochloride",
"pos": [
12,
40
]
} |
the bioavailability of digoxin ( lanoxin ) tablets , oral aqueous solution of digoxin , and capsules containing a solution of digoxin was compared with digoxin given intravenously over 1 and 3 hr . | tradename_of | {
"id": "C0699988",
"name": "lanoxin",
"pos": [
33,
40
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
152,
159
]
} |
cytostatic drugs under clinical trial [ elobromol ( dbd ) , myelobromol ( dbm ) , lycurim ( ly ) , zitostop ( zi ) ] , others in preclinical analysis [ dianhydrogalactitol ( dag ) , 3,4-diacetyldianhydrogalactitol ( diacdag ) , 3,4-disuccinyldianhydrogalactitol ( disudag ) ] , and compounds without any known antitumor effect in transplantable tumors [ 1-bromo-3,6-anhydrodulcitol ( bad ) , 1,2-epoxi-3,6-anhydrodulcitol ( ead ) ] were examined . | tradename_of | {
"id": "C0878349",
"name": "elobromol",
"pos": [
40,
49
]
} | {
"id": "C0026252",
"name": "dbd",
"pos": [
52,
55
]
} |
cross-resistance , as determined by comparison of drug effects on rates of proliferation of l1210/c2 and l1210/ara-a cells , was seen with adenosine , deoxyadenosine , methylmercaptopurine ribonucleoside , tubercidin , and cordycepin but not with 1-beta-d-arabinofuranosylcytosine or with 9-beta-d-arabinofuranosyl-2-fluoroadenine . | tradename_of | {
"id": "C1511626",
"name": "ara",
"pos": [
111,
114
]
} | {
"id": "C0010711",
"name": "arabinofuranosylcytosine",
"pos": [
256,
280
]
} |
three different sustained-release tablets of theophylline ( theo-dur , phyllocontin continus , euphyllin retard ) and an oral elixir of aminophylline were administered to 12 healthy volunteers according to a crossover scheme . | tradename_of | {
"id": "C0722625",
"name": "phyllocontin",
"pos": [
71,
83
]
} | {
"id": "C0002575",
"name": "aminophylline",
"pos": [
136,
149
]
} |
47 patients were treated with niridazole ( ambilhar , 25 mg/kg , 5-7 days ) , 2 patients with praziquantel ( biltricide , 40 mg/kg , 1 day ) and 2 other patients with praziquantel after unsuccessful niridazole therapy . | tradename_of | {
"id": "C0702014",
"name": "biltricide",
"pos": [
109,
119
]
} | {
"id": "C0032911",
"name": "praziquantel",
"pos": [
167,
179
]
} |
less morphine was required for ms contin given every 12 hours relative to immediate-release morphine sulfate given every 4 hours ( 186 +/- 22 mg vs. 239 +/- 35 mg ; p = 0.04 ) . | tradename_of | {
"id": "C0700786",
"name": "ms",
"pos": [
31,
33
]
} | {
"id": "C0066814",
"name": "morphine sulfate",
"pos": [
92,
108
]
} |
one year later , after the antihypertensive medication had been changed from adalat ( nifedipine ) to teneretic ( atenolol , chlortalidone ) the eczematous photosensitive reaction recurred . | tradename_of | {
"id": "C0590658",
"name": "adalat",
"pos": [
77,
83
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
86,
96
]
} |
doxorubicin , vehem ( teniposide ) , and vepeside ( etoposide ) induced hypotension , tachycardia , and a rise in histamine levels . | tradename_of | {
"id": "C0733481",
"name": "vehem",
"pos": [
14,
19
]
} | {
"id": "C0039512",
"name": "teniposide",
"pos": [
22,
32
]
} |
the quality of life was assessed in 37 maintenance hemodialysis patients during treatment with recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) for correction of anemia . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
140,
146
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
149,
161
]
} |
the effect of long-term hemodialysis in 58 nonanemic end-stage renal disease patients treated with recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) has been examined in detail . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
144,
150
]
} | {
"id": "C0357126",
"name": "epoetin",
"pos": [
153,
160
]
} |
extensive testing has proven that recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) corrects the anemia of end-stage renal disease and eliminates the need for transfusions in virtually all patients . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
79,
85
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
88,
100
]
} |
treatment with recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) rapidly corrects the anemia associated with end-stage renal disease during the acute phase of therapy and supports hematocrit levels throughout the maintenance phase . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
60,
66
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
69,
81
]
} |
and ( 3 ) the influence of the preoperative administration of aspirin , persantine ( dipyridamole ) , heparin sodium , thrombolytic agents , coumadin ( crystalline warfarin sodium ) , and nonsteroid , antiinflammatory drugs on homologous blood usage and bleeding in cardiac operations utilizing intraoperative autotransfusion and autologous platelet-rich plasma collected intraoperatively . | tradename_of | {
"id": "C0700020",
"name": "persantine",
"pos": [
72,
82
]
} | {
"id": "C0012582",
"name": "dipyridamole",
"pos": [
85,
97
]
} |
and ( 3 ) the influence of the preoperative administration of aspirin , persantine ( dipyridamole ) , heparin sodium , thrombolytic agents , coumadin ( crystalline warfarin sodium ) , and nonsteroid , antiinflammatory drugs on homologous blood usage and bleeding in cardiac operations utilizing intraoperative autotransfusion and autologous platelet-rich plasma collected intraoperatively . | tradename_of | {
"id": "C0699129",
"name": "coumadin",
"pos": [
141,
149
]
} | {
"id": "C0376218",
"name": "warfarin sodium",
"pos": [
164,
179
]
} |
[ omnipaque ( iohexol ) ct myelography ( ctm ) in the diagnosis of cervical spondylotic myelopathy -- correlative study of conventional myelography ( a report of 100 cases ) ] . | tradename_of | {
"id": "C0729203",
"name": "omnipaque",
"pos": [
2,
11
]
} | {
"id": "C0022005",
"name": "iohexol",
"pos": [
14,
21
]
} |
muromonab cd3 ( orthoclone okt3 , orthoclone , okt3 ) is the first monoclonal antibody to become available for therapy in humans . | tradename_of | {
"id": "C0733466",
"name": "orthoclone okt3",
"pos": [
16,
31
]
} | {
"id": "C0085379",
"name": "okt3",
"pos": [
47,
51
]
} |
effective monitoring of chronic hemodialysis patients treated with recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) includes an initial evaluation of the patient , the patient 's anemia , and the patient 's iron stores . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
112,
118
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
121,
133
]
} |
onset or exacerbation of hypertension has been observed as a possible complication of recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) therapy for the anemia of end-stage renal disease . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
131,
137
]
} | {
"id": "C0357126",
"name": "epoetin",
"pos": [
140,
147
]
} |
iron deficiency frequently complicates both acute and chronic phases of recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) therapy for dialysis-associated anemia . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
117,
123
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
126,
138
]
} |
treatment with recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) increases hematocrit values and thus reduces the anemia , in turn improving brain and cognitive function , exercise tolerance , sexual potency , and quality of life . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
60,
66
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
69,
81
]
} |
the treatment of severe anemia related to end-stage renal disease with recombinant human erythropoietin ( r-huepo ; epogen , [ epoetin alfa ] amgen inc , thousand oaks , ca ) has been investigated in more than 1,500 hemodialysis patients worldwide . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
116,
122
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
127,
139
]
} |
recombinant human erythropoietin ( r-huepo ; epogen [ epoetin alfa ] , amgen inc , thousand oaks , ca ) has proven to be an effective agent in treating the anemia of chronic renal failure . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
45,
51
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
54,
66
]
} |
all operative survivors were anticoagulated with coumadin ( crystalline warfarin sodium ) to maintain the prothrombin time at 1.5 times control . | tradename_of | {
"id": "C0699129",
"name": "coumadin",
"pos": [
49,
57
]
} | {
"id": "C0376218",
"name": "warfarin sodium",
"pos": [
72,
87
]
} |
adriamycin ( doxorubicin hydrochloride ) is an antineoplastic agent effective against a wide range of malignant conditions , although cardiac toxicity , especially dose-dependent cardiomyopathy , limits its long-term use . | tradename_of | {
"id": "C0085752",
"name": "adriamycin",
"pos": [
0,
10
]
} | {
"id": "C0546861",
"name": "doxorubicin hydrochloride",
"pos": [
13,
38
]
} |
two thousand one hundred and forty four patients received plaquenil ( hydroxychloroquine sulphate ) prior to total hip arthroplasty ; | tradename_of | {
"id": "C0699177",
"name": "plaquenil",
"pos": [
58,
67
]
} | {
"id": "C0596007",
"name": "hydroxychloroquine sulphate",
"pos": [
70,
97
]
} |
[ relationship between bronchial sensitivity to histamine aerosol and histaminemia in patients with atopic asthma during treatment with intal ( dscg ) ] . | tradename_of | {
"id": "C0591652",
"name": "intal",
"pos": [
136,
141
]
} | {
"id": "C0012694",
"name": "dscg",
"pos": [
144,
148
]
} |
treatment must be given very early , whether ara a antiviral dna or isoprinosine ( inosiplex ) which stimulates cellular immunity , as soon after diagnosis has been established as possible . | tradename_of | {
"id": "C0795760",
"name": "isoprinosine",
"pos": [
68,
80
]
} | {
"id": "C0022230",
"name": "inosiplex",
"pos": [
83,
92
]
} |
a clinical trial using airol cream ( retinoic acid cream 0.05 % ) , panoxyl-5 and panoxyl-10 ( benzoyl-peroxide alcoholic gel 5 % & 10 % ) in combination and alone as topical applications for 10 weeks was carried out on 150 ambulatory patients with acne vulgaris . | tradename_of | {
"id": "C1520050",
"name": "airol",
"pos": [
23,
28
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
37,
50
]
} |
the small elimination capacity for intralipid , however , demands caution in the uncontrolled application of this fat emulsion to severely ill patients . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
35,
45
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
114,
126
]
} |
two solid phase , nonradioactive immunoassays were developed and evaluated for the determination of zidovudine ( retrovir , zdv , azt ) concentrations in serum . | tradename_of | {
"id": "C0699576",
"name": "retrovir",
"pos": [
113,
121
]
} | {
"id": "C0043474",
"name": "azt",
"pos": [
130,
133
]
} |
danocrine ( danazol ) , an isoxazol derivative of 17-alpha ethinyl-testosterone , when used at appropriate dosages , is an excellent drug for the treatment of endometriosis . | tradename_of | {
"id": "C0813502",
"name": "danocrine",
"pos": [
0,
9
]
} | {
"id": "C0010961",
"name": "danazol",
"pos": [
12,
19
]
} |
among noninfectious conditions that cause adhesions , endometriosis is the most common . a six-month preoperative regimen of danocrine ( danazol ) resulted in a reduction in pelvic vascularity and inflammation , theoretically reducing the risk of postoperative adhesions . | tradename_of | {
"id": "C0813502",
"name": "danocrine",
"pos": [
125,
134
]
} | {
"id": "C0010961",
"name": "danazol",
"pos": [
137,
144
]
} |
it was not until 1971 , when danocrine ( danazol ) was introduced for the treatment of endometriosis , that the potential usefulness of this synthetic steroid in the management of benign breast disorders was recognized . | tradename_of | {
"id": "C0813502",
"name": "danocrine",
"pos": [
29,
38
]
} | {
"id": "C0010961",
"name": "danazol",
"pos": [
41,
48
]
} |
this procedure has been used with considerable success to reproduce the signs and symptoms of asherman 's syndrome when combined with pretreatment using the synthetic steroid danocrine ( danazol ) . | tradename_of | {
"id": "C0813502",
"name": "danocrine",
"pos": [
175,
184
]
} | {
"id": "C0010961",
"name": "danazol",
"pos": [
187,
194
]
} |
the author 's experience with the use of danocrine ( danazol ) on 21 patients with pms suggests that this synthetic steroid , when used in conjunction with nonpharmacologic treatment options , relieves the symptoms of pms in up to 85 % of patients . | tradename_of | {
"id": "C0813502",
"name": "danocrine",
"pos": [
41,
50
]
} | {
"id": "C0010961",
"name": "danazol",
"pos": [
53,
60
]
} |
effect of enzyme induction on sandimmun ( cyclosporin a ) biotransformation and hepatotoxicity in cultured rat hepatocytes and in vivo . | tradename_of | {
"id": "C0699604",
"name": "sandimmun",
"pos": [
30,
39
]
} | {
"id": "C0010592",
"name": "cyclosporin a",
"pos": [
42,
55
]
} |
this study was designed to examine the relationship between the extent of sandimmun ( cyclosporin a , sim ) metabolism and sim-induced hepatotoxicity both in vivo and in primary cultures of rat hepatocytes . | tradename_of | {
"id": "C0699604",
"name": "sandimmun",
"pos": [
74,
83
]
} | {
"id": "C0010592",
"name": "cyclosporin a",
"pos": [
86,
99
]
} |
a multicentre double-blind comparative trial was performed in 138 patients with rheumatoid arthritis ( ra ) after biweekly intravenous or intramuscular injections of liposteroid ( containing 2.5 mg of dexamethasone ) , which had been developed as a drug for targeting therapy of ra , and decadron ( containing 3.3 mg of dexamethasone ) as a reference drug . | tradename_of | {
"id": "C0740057",
"name": "decadron",
"pos": [
288,
296
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
320,
333
]
} |
a clinical trial with delimmun ( inosiplex ) for 14 days did not show any clinical or immunologic improvement in this patient . | tradename_of | {
"id": "C1435085",
"name": "delimmun",
"pos": [
22,
30
]
} | {
"id": "C0022230",
"name": "inosiplex",
"pos": [
33,
42
]
} |
a prospective randomized trial was performed comparing the efficacy of intraperitoneal irrigation with low molecular weight povidone-iodine solution ( 'betadine lmw ' ) ( pvp-i lmw ) in reducing the risk of intra-abdominal infectious complications . | tradename_of | {
"id": "C0699524",
"name": "betadine",
"pos": [
152,
160
]
} | {
"id": "C0032857",
"name": "pvp-i",
"pos": [
171,
176
]
} |
a physico-chemical study of pvp-i solutions leading to the reformulation of 'betadine ' preparations ( 5 % pvp-i ) . | tradename_of | {
"id": "C0699524",
"name": "betadine",
"pos": [
77,
85
]
} | {
"id": "C0032857",
"name": "pvp-i",
"pos": [
107,
112
]
} |
a double-blind , randomized study was performed to compare discomfort and pain associated with the use of iopamidol and hypaque ( diatrizoate sodium and diatrizoate meglumine ) during iliofemoral runoff arteriography in 33 patients . | tradename_of | {
"id": "C0813724",
"name": "hypaque",
"pos": [
120,
127
]
} | {
"id": "C0012007",
"name": "diatrizoate sodium",
"pos": [
130,
148
]
} |
we report on two female patients suffering from mycosis fungoides , tumorous type but without systemic involvement , who have been treated with 400 mg zovirax ( acyclovir ) 3 times daily ( about 15 mg/kg/day ) for 12 days . | tradename_of | {
"id": "C0592290",
"name": "zovirax",
"pos": [
151,
158
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
161,
170
]
} |
in a group of seven dogs in whom heparin and trasylol ( aprotinin ) were added to the pancreatic tissue at the time of transplantation , portal pressure rose only to a peak of 28.3 cm of h ( 2 ) o +/- 3.6 and no significant abnormalities occurred in mean hematocrit value , plasma fibrinogen , platelet count or eclt . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
45,
53
]
} | {
"id": "C0003641",
"name": "aprotinin",
"pos": [
56,
65
]
} |
inhibition of sindbis virus replication in aedes albopictus cells by virazole ( ribavirin ) and its reversal by actinomycin : a correction . | tradename_of | {
"id": "C1622085",
"name": "virazole",
"pos": [
69,
77
]
} | {
"id": "C0035525",
"name": "ribavirin",
"pos": [
80,
89
]
} |
isoprinosine ( inosiplex ) , a proposed antiviral agent , was given to 18 patients with subacute sclerosing panencephalitis ( sspe ) . | tradename_of | {
"id": "C0795760",
"name": "isoprinosine",
"pos": [
0,
12
]
} | {
"id": "C0022230",
"name": "inosiplex",
"pos": [
15,
24
]
} |
the results of the anturane reinfarction trial , a randomized , double-blind , multicenter clinical trial , represent the data on 1558 patients who received either sulfinpyrazone or placebo for an average of 16 months , starting 25 to 35 days after a documented myocardial infarction . | tradename_of | {
"id": "C0591099",
"name": "anturane",
"pos": [
19,
27
]
} | {
"id": "C0038742",
"name": "sulfinpyrazone",
"pos": [
164,
178
]
} |
the propylene glycol content of valium inj . is said to cause a delayed release of the drug from the injection site after i.m . application , and this is briefly discussed , as well as the possibility of administering the diazepam emulsion continuously , diluted with intralipid , without the risk of precipitation . | tradename_of | {
"id": "C0699187",
"name": "valium",
"pos": [
32,
38
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
222,
230
]
} |
statistically , plaquenil ( hydroxychloroquine sulphate ) , was as good as any of the other methods used and had few complications . | tradename_of | {
"id": "C0699177",
"name": "plaquenil",
"pos": [
16,
25
]
} | {
"id": "C0596007",
"name": "hydroxychloroquine sulphate",
"pos": [
28,
55
]
} |
twenty-two patients with herpes simplex were treated with betadine ( povidone iodine ) antiseptic paint and seven with 5 % idoxuridine in dimethyl sulphoxide , also one patient with bilateral lesions was treated with the two solutions , one on each side . | tradename_of | {
"id": "C0699524",
"name": "betadine",
"pos": [
58,
66
]
} | {
"id": "C0032857",
"name": "povidone",
"pos": [
69,
77
]
} |
[ experiences with a new preparation , tantum biotic . ( benzydamine hydrochloride + tetracycline ) in a surgical clinic ] . | tradename_of | {
"id": "C1511108",
"name": "tantum",
"pos": [
39,
45
]
} | {
"id": "C0282070",
"name": "benzydamine hydrochloride",
"pos": [
57,
82
]
} |
time- and dose-dependent patterns of depletion and regeneration of hemopoietic progenitor cells in mouse femora and spleens following treatment with the antileukemic agent myleran ( busulphan , my ) were studied using the murine spleen colony system and the agar gel in vitro colony system . | tradename_of | {
"id": "C0700015",
"name": "myleran",
"pos": [
172,
179
]
} | {
"id": "C0006463",
"name": "busulphan",
"pos": [
182,
191
]
} |
in a second series of experiments in which intralipid was compared with 0.9 % nacl it was demonstrated that the fat emulsion alone gave rise to considerable inflammatory changes in the veins . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
43,
53
]
} | {
"id": "C0304483",
"name": "fat",
"pos": [
112,
115
]
} |
the effect of the individual components of dopram ( r ) ( doxapram hydrochloride and chlorobutanol ) on hexobarbital narcosis and hypothermia was evaluated . | tradename_of | {
"id": "C0699979",
"name": "dopram",
"pos": [
43,
49
]
} | {
"id": "C0282152",
"name": "doxapram hydrochloride",
"pos": [
58,
80
]
} |
the corresponding reactions of kepone ( chlordecone ) , in contrast , occur with predominant formation of indene derivatives . | tradename_of | {
"id": "C0878176",
"name": "kepone",
"pos": [
31,
37
]
} | {
"id": "C0022562",
"name": "chlordecone",
"pos": [
40,
51
]
} |
we have validated a method to measure bile salt binding by maalox ( aluminum hydroxide and magnesium hydroxide ) , carafate ( sucralfate ) , and questran ( cholestyramine ) in vitro . | tradename_of | {
"id": "C0740157",
"name": "carafate",
"pos": [
115,
123
]
} | {
"id": "C0038633",
"name": "sucralfate",
"pos": [
126,
136
]
} |
we have validated a method to measure bile salt binding by maalox ( aluminum hydroxide and magnesium hydroxide ) , carafate ( sucralfate ) , and questran ( cholestyramine ) in vitro . | tradename_of | {
"id": "C0699311",
"name": "questran",
"pos": [
145,
153
]
} | {
"id": "C0008402",
"name": "cholestyramine",
"pos": [
156,
170
]
} |
augmentin ( amoxycillin plus clavulanic acid to protect it against enzymatic hydrolysis ) appeared to have a suppressive effect on the indigenous colonization-resistance-associated microflora . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
0,
9
]
} | {
"id": "C0054066",
"name": "amoxycillin",
"pos": [
12,
23
]
} |
through a compassionate plea program ( treatment investigational new drug ) , 4805 patients with acquired immunodeficiency syndrome who previously had experienced pneumocystis carinii pneumonia ( pcp ) received zidovudine ( retrovir , formerly azidothymidine ) . | tradename_of | {
"id": "C0699576",
"name": "retrovir",
"pos": [
224,
232
]
} | {
"id": "C0043474",
"name": "azidothymidine",
"pos": [
244,
258
]
} |
this study was designed to determine the stability of certain vitamins added to total parenteral nutrition ( tpn ) admixtures with or without intralipid iv fat emulsion and with each of four amino acid solutions stored in either glass bottles or plastic bags at either ambient room ( 25 degrees c ) or refrigerator ( 5 degrees c ) temperature for a 48-hr period . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
142,
152
]
} | {
"id": "C0304483",
"name": "fat",
"pos": [
156,
159
]
} |
the taste of klorvess was rated significantly more palatable than kaochlor ( p less than 0.01 ) or kayciel ( p less than 0.05 ) . | tradename_of | {
"id": "C0721247",
"name": "klorvess",
"pos": [
13,
21
]
} | {
"id": "C0032825",
"name": "kaochlor",
"pos": [
66,
74
]
} |
klorvess was rated significantly more acceptable if taken over a long period of time than kaochlor ( p less than 0.01 ) or kayciel ( p less than 0.01 ) . | tradename_of | {
"id": "C0721247",
"name": "klorvess",
"pos": [
0,
8
]
} | {
"id": "C0032825",
"name": "kaochlor",
"pos": [
90,
98
]
} |
the amount of klorvess returned was significantly less than the amount of either kayciel ( p less than 0.01 ) or kaochlor ( p less than 0.01 ) . | tradename_of | {
"id": "C0721247",
"name": "klorvess",
"pos": [
14,
22
]
} | {
"id": "C0032825",
"name": "kaochlor",
"pos": [
113,
121
]
} |
mezlocillin ( baypen ) , carbenicillin and mezlocillin combined with gentamicin , sisomicin , tobramycin and amikacin , respectively , were tested in vitro against 325 fresh clinical isolates of pathogenic gram-negative bacteria using the tube dilution procedure . | tradename_of | {
"id": "C0701901",
"name": "baypen",
"pos": [
14,
20
]
} | {
"id": "C0025893",
"name": "mezlocillin",
"pos": [
43,
54
]
} |
evaluation of monistat cream ( miconazole nitrate 2 % ) in a reduced regimen for the treatment of vulvovaginal candidiasis . | tradename_of | {
"id": "C1177005",
"name": "monistat",
"pos": [
14,
22
]
} | {
"id": "C0086620",
"name": "miconazole nitrate",
"pos": [
31,
49
]
} |
two cases of neonatal bowel opacification secondary to oral and rectal administration of kayexalate ( sodium polystyrene sulfonate ) are presented . | tradename_of | {
"id": "C0124498",
"name": "kayexalate",
"pos": [
89,
99
]
} | {
"id": "C0142915",
"name": "sodium polystyrene sulfonate",
"pos": [
102,
130
]
} |
trasylol ( aprotinin ) , a single chain peptide with three disulphide bonds , was an ineffective inhibitor even in massive molar excess . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
0,
8
]
} | {
"id": "C0003641",
"name": "aprotinin",
"pos": [
11,
20
]
} |
the management of bronchial asthma in children under the age of 3 1/2 years using intal ( sodium cromoglycate ) administered by spinhaler . | tradename_of | {
"id": "C0591652",
"name": "intal",
"pos": [
82,
87
]
} | {
"id": "C0012694",
"name": "sodium cromoglycate",
"pos": [
90,
109
]
} |
rhesus monkeys , macaca mulatta , were treated with the oral contraceptives brevicon ( norethisterone with ethinylestradiol ) and ovral ( norgestrel with ethinylestradiol ) , and subsequently inoculated with the simian malaria parasites plasmodium cynomologi bastianellii or p. coatneyi . | tradename_of | {
"id": "C0107153",
"name": "brevicon",
"pos": [
76,
84
]
} | {
"id": "C1260235",
"name": "norethisterone",
"pos": [
87,
101
]
} |
20 to 30 min after sublingual administration of 1 adalat capsule ( 10 mg nifedipine ) a decrease in arterial pressure and systemic resistance , and an increase in heart rate and cardiac output were observed already at rest . | tradename_of | {
"id": "C0590658",
"name": "adalat",
"pos": [
50,
56
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
73,
83
]
} |
we investigated the capability of pepto-bismol and its components ( veegum and bismuth subsalicylate ) to sequester bile acids from aqueous solution in vitro and compared it to that of cholestyramine . | tradename_of | {
"id": "C0136074",
"name": "pepto-bismol",
"pos": [
34,
46
]
} | {
"id": "C0053792",
"name": "bismuth subsalicylate",
"pos": [
79,
100
]
} |
two controlled-release theophylline drugs , t-d ( theo-dur tablets ) administered 12-hourly , and preparation u ( uniphyl tablets ) once daily , given in 7-day sequences in daily 800-mg doses , produced comparable steady-state serum profiles in nonsmoking adults with asthma , chronic bronchitis , or both , showing acceptable theophylline clearances . | tradename_of | {
"id": "C0700814",
"name": "uniphyl",
"pos": [
114,
121
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
327,
339
]
} |
a randomized double blind study with iohexol ( omnipaque ) and metrizamide ( amipaque ) in cervical myelography was performed in 50 patients , 29 with iohexol and 21 with metrizamide . | tradename_of | {
"id": "C0729203",
"name": "omnipaque",
"pos": [
47,
56
]
} | {
"id": "C0022005",
"name": "iohexol",
"pos": [
151,
158
]
} |
in the chronic course of the disease with slow enlargement of the head size , it is indicated to use diacarb ( acetazolamide ) which is a carboanhydrase inhibitor and decreases the production of the cerebrospinal fluid . | tradename_of | {
"id": "C0699248",
"name": "diacarb",
"pos": [
101,
108
]
} | {
"id": "C0000981",
"name": "acetazolamide",
"pos": [
111,
124
]
} |
the problem is to find an effective and safe drug combination for travellers to areas where p. falciparum is either resistant to chloroquine , to fansidar ( the combination of pyrimethamine plus sulfadoxine ) or to both . | tradename_of | {
"id": "C0060061",
"name": "fansidar",
"pos": [
146,
154
]
} | {
"id": "C0700599",
"name": "pyrimethamine",
"pos": [
176,
189
]
} |
besides 6-hydroxychlorzoxazon ii , the main metabolite of 5-chlorobenzoxazolin-2-one ( chlorzoxazone i , paraflex ) two other compounds were found to be metabolites of chlorzoxazone : 5-chloro-2,4-dihydroxyacetanilide xxii is produced from 6-hydroxychlorzoxazone ii by ring cleavage and acetylation of the nitrogen . | tradename_of | {
"id": "C0813433",
"name": "paraflex",
"pos": [
105,
113
]
} | {
"id": "C0008296",
"name": "chlorzoxazone",
"pos": [
249,
262
]
} |
thirteen patients with a mean age of 67 years admitted to hospital with signs and symptoms of lower respiratory infections were treated with 'augmentin ' ( 500 mg amoxycillin + 250 mg clavulanic acid ) given orally every 8 hours , for 7 days . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
142,
151
]
} | {
"id": "C0054066",
"name": "amoxycillin",
"pos": [
163,
174
]
} |
the intraventricular administration of vasopressin or ddavp ( desmopressin acetate ) increased the brain water content from 78.2 % to 79.2-79.5 % . | tradename_of | {
"id": "C0701195",
"name": "ddavp",
"pos": [
54,
59
]
} | {
"id": "C0086135",
"name": "desmopressin",
"pos": [
62,
74
]
} |
comparative trial of viokase , pancreatin and pancrease pancrelipase ( enteric coated beads ) in the treatment of malabsorption in cystic fibrosis . | tradename_of | {
"id": "C0702058",
"name": "pancrease",
"pos": [
46,
55
]
} | {
"id": "C0770343",
"name": "pancrelipase",
"pos": [
56,
68
]
} |