text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
citrucel , made from methylcellulose , is completely soluble in water and may result in improved compliance from improved palatability . | tradename_of | {
"id": "C0305648",
"name": "citrucel",
"pos": [
0,
8
]
} | {
"id": "C0025729",
"name": "methylcellulose",
"pos": [
21,
36
]
} |
we studied the clinical efficacy and prophylactic effect of tomiron ( cefteram pivoxil ; cftm-pi ) , a new oral cephalosporin , in the surgical patients . | tradename_of | {
"id": "C0146210",
"name": "tomiron",
"pos": [
60,
67
]
} | {
"id": "C0108947",
"name": "cefteram",
"pos": [
70,
78
]
} |
[ effect of various doses of atarax ( hydroxyzine hydrochloride ) on the development of the chick embryo ] . | tradename_of | {
"id": "C0684229",
"name": "atarax",
"pos": [
29,
35
]
} | {
"id": "C0600110",
"name": "hydroxyzine hydrochloride",
"pos": [
38,
63
]
} |
ten puffs ( 1.5 mg as adrenaline base ) with 10-15 s intervals between them followed 2 h later by 20 puffs ( 3 mg ) of adrenaline from a pressurized aerosol ( medihaler-epi , 3m riker , 14.0 mg/ml adrenaline acid tartrate ) were sprayed into the cheek pouch or inhaled through the mouth or the nostrils . | tradename_of | {
"id": "C0025133",
"name": "medihaler-epi",
"pos": [
159,
172
]
} | {
"id": "C0700536",
"name": "adrenaline acid tartrate",
"pos": [
197,
221
]
} |
following recent reports of the development of skeletal abnormalities in patients treated with etretinate ( tigason ) , we have examined 19 children and adolescents on long-term treatment with etretinate , using 99mtechnetium methylene diphosphonate ( 99mtcmdp ) whole body bone scans and musculoskeletal assessment . | tradename_of | {
"id": "C0729231",
"name": "tigason",
"pos": [
108,
115
]
} | {
"id": "C0015137",
"name": "etretinate",
"pos": [
193,
203
]
} |
a unique hepatic adenoma developed in a 26-year-old woman who had used oral contraceptives for 10 years and tolinase ( tolazamide sulfonylurea ) for adult-onset diabetes mellitus for five years . | tradename_of | {
"id": "C0723773",
"name": "tolinase",
"pos": [
108,
116
]
} | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
119,
129
]
} |
as part of an outpatient treatment research project alternative ways of using antabuse ( disulfiram ) in the treatment of problem drinkers are developed . | tradename_of | {
"id": "C0591096",
"name": "antabuse",
"pos": [
78,
86
]
} | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
89,
99
]
} |
the efficacy of trental ( pentoxifylline ) in the treatment of intermittent claudication was evaluated in 14 double-blind randomized studies , involving 475 patients with chronic occlusive vascular disease . | tradename_of | {
"id": "C0699487",
"name": "trental",
"pos": [
16,
23
]
} | {
"id": "C0030899",
"name": "pentoxifylline",
"pos": [
26,
40
]
} |
these resembled in general morphology and element composition the particles seen within aurosomes in platelets treated with myochrysine ( gstm ) and in synovium and other tissues by other workers . | tradename_of | {
"id": "C0700008",
"name": "myochrysine",
"pos": [
124,
135
]
} | {
"id": "C0018034",
"name": "gstm",
"pos": [
138,
142
]
} |
when the peritoneum and transverse muscle had been sutured , the wounds of the animals in the trial group were irrigated and washed with 300 ml . of betadine ( 10 per cent of pvp-iodine in water ) . | tradename_of | {
"id": "C0699524",
"name": "betadine",
"pos": [
149,
157
]
} | {
"id": "C0032857",
"name": "pvp-iodine",
"pos": [
175,
185
]
} |
theo-24 , a formulation intended for once-daily dosing , produced larger fluctuations in serum theophylline concentration ( stc ) than did twice-daily theo-dur ( 214 +/- 106 % versus 89 +/- 33 % , p less than 0.02 ) . | tradename_of | {
"id": "C0700825",
"name": "theo-24",
"pos": [
0,
7
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
95,
107
]
} |
similarly , the mean cmax for theo-24 was 14.5 ( range , 6.2-20.4 micrograms/ml ) , and the mean 10-h post-dose stc was 13.7 ( range , 3.6 to 20.4 micrograms/ml ) , suggesting that this time point approximates the true cmax . | tradename_of | {
"id": "C0700825",
"name": "theo-24",
"pos": [
30,
37
]
} | {
"id": "C0039771",
"name": "stc",
"pos": [
112,
115
]
} |
subsequent cytotoxic treatment , including vp-16 , velban ( vinblastine sulfate ) , and methotrexate ( mtx ) controlled the disease for a few months but the child died with a clinical picture of meningocephalitis 1.5 years later . | tradename_of | {
"id": "C0728761",
"name": "velban",
"pos": [
51,
57
]
} | {
"id": "C0042671",
"name": "vinblastine",
"pos": [
60,
71
]
} |
a safflower oil emulsion ( liposyn 20 % ) containing no alpha-linolenic acid was given to the group 1 subjects , while a modified emulsion containing 3 % of alpha-linolenic acid in safflower oil supplying 5.6 % of total calories was given to those of group 2 . | tradename_of | {
"id": "C0065066",
"name": "liposyn",
"pos": [
27,
34
]
} | {
"id": "C0036048",
"name": "safflower oil",
"pos": [
181,
194
]
} |
relationship between rate and extent of absorption of oral theophylline from uniphyl brand of slow-release theophylline and resulting serum concentrations during multiple dosing . | tradename_of | {
"id": "C0700814",
"name": "uniphyl",
"pos": [
77,
84
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
107,
119
]
} |
the reparative effect of antabuse ( tetraethylthiuram disulfide ) upon dental changes in vitamin e deficient rats . | tradename_of | {
"id": "C0591096",
"name": "antabuse",
"pos": [
25,
33
]
} | {
"id": "C0012772",
"name": "tetraethylthiuram disulfide",
"pos": [
36,
63
]
} |
on the basis of comparative studies , the conclusion is made that phenazepam is not worse by its psychotropic activity than ativan ( lorazepam ) and exceeds diazepam ( seduxen ) , most likely because of its myorelaxing action . | tradename_of | {
"id": "C0699194",
"name": "ativan",
"pos": [
124,
130
]
} | {
"id": "C0024002",
"name": "lorazepam",
"pos": [
133,
142
]
} |
a stong downward trend in average daily dose was found , equivalent to a halving in lanoxin , almost as much in digoxin , and a one-fifth fall in prepared digitalis . | tradename_of | {
"id": "C0699988",
"name": "lanoxin",
"pos": [
84,
91
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
112,
119
]
} |
from 1972 the proprietary 250 microgram tablet of lanoxin was prescribed increasingly at the expense of unbranded digoxin , but at a lower daily frequency until 1975 . | tradename_of | {
"id": "C0699988",
"name": "lanoxin",
"pos": [
50,
57
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
114,
121
]
} |
a double-blind , cross-over comparison of naprosyn ( naproxen ) 750 mg daily and butacote ( enteric-coated phenylbutazone ) 300 mg daily was carried out in a multi-centre trial . | tradename_of | {
"id": "C0700017",
"name": "naprosyn",
"pos": [
42,
50
]
} | {
"id": "C0027396",
"name": "naproxen",
"pos": [
53,
61
]
} |
intal drops ( sodium cromoglycate ) relieved symptoms of vernal conjunctivitis in all the 19 patients we studied , reducing the need for steroids although the response varied . | tradename_of | {
"id": "C0591652",
"name": "intal",
"pos": [
0,
5
]
} | {
"id": "C0012694",
"name": "sodium cromoglycate",
"pos": [
14,
33
]
} |
inhibitory and cytotoxic effects of oncovin ( vincristine sulfate ) on cells of human line nhik 3025 . | tradename_of | {
"id": "C0591904",
"name": "oncovin",
"pos": [
36,
43
]
} | {
"id": "C0042680",
"name": "vincristine sulfate",
"pos": [
46,
65
]
} |
the inhibitory effect of oncovin ( vincristine sulfate ) on cell division was studied in human cell line nhik 3025 . | tradename_of | {
"id": "C0591904",
"name": "oncovin",
"pos": [
25,
32
]
} | {
"id": "C0042680",
"name": "vincristine sulfate",
"pos": [
35,
54
]
} |
the effects of the analeptic agent , dopram ( doxapram hydrochloride ) were investigated in 2 ponies during immobilon - induced neuroleptanalgesia . | tradename_of | {
"id": "C0699979",
"name": "dopram",
"pos": [
37,
43
]
} | {
"id": "C0282152",
"name": "doxapram hydrochloride",
"pos": [
46,
68
]
} |
repeated oral administration of a therapeutically effective dose of orudis ( 50 mg q.i.d . ) , resulted in the rapid attainment of a plateau plasma level of ketoprofen , which was maintained throughout the course of dosing . | tradename_of | {
"id": "C0700190",
"name": "orudis",
"pos": [
68,
74
]
} | {
"id": "C0022635",
"name": "ketoprofen",
"pos": [
157,
167
]
} |
thirty-four patients with glaucoma were treated with the ocusert pilocarpine system , a unique method of providing round-the-clock delivery of pilocarpine in the eye for seven-day periods . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
57,
64
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
143,
154
]
} |
overall , when compared to pilocarpine eyedrops , the ocusert pilocarpine system presents many definite advantages and is a highly desirable method of therapy in selected cases of glaucoma . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
54,
61
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
62,
73
]
} |
a case report is presented in which an acute , transient myopia of 3 diopters is induced by hygroton ( chlorthalidone ) , a monosulfamyl diuretic and antihypertensive drug . | tradename_of | {
"id": "C0591623",
"name": "hygroton",
"pos": [
92,
100
]
} | {
"id": "C0008294",
"name": "chlorthalidone",
"pos": [
103,
117
]
} |
an analysis designed to infer the maximum possible advantage of thorazine over generic chlorpromazine indicated that differences between the two were clinically insignificant . | tradename_of | {
"id": "C0699065",
"name": "thorazine",
"pos": [
64,
73
]
} | {
"id": "C0008286",
"name": "chlorpromazine",
"pos": [
87,
101
]
} |
virazole ( ribavirin , icn 1229 ) , a broad-spectrum , antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis b surface antigen ( hb ( s ) ag ) -seropositive chimpanzees . | tradename_of | {
"id": "C1622085",
"name": "virazole",
"pos": [
0,
8
]
} | {
"id": "C0035525",
"name": "ribavirin",
"pos": [
11,
20
]
} |
in comparison with phisohex ( 3 % hexachlorophane in detergent cream ) , the established surgical scrub of the operating team for many years , hibiscrub maintained marginally more significant residual disinfection ( p 0.05 ) . | tradename_of | {
"id": "C0308205",
"name": "phisohex",
"pos": [
19,
27
]
} | {
"id": "C0019435",
"name": "hexachlorophane",
"pos": [
34,
49
]
} |
in this group , the mean area under the curve ( auc ) with msc was 443.6 +/- 348.4 ng/ml/hour , compared with 406.8 +/- 259.7 ng/ml/hour for mss ( p greater than 0.20 ) . | tradename_of | {
"id": "C0700786",
"name": "msc",
"pos": [
59,
62
]
} | {
"id": "C0066814",
"name": "mss",
"pos": [
141,
144
]
} |
mean maximum morphine concentrations ( cmax ) for msc and mss were 67.9 +/- 42.1 and 58.8 +/- 30.3 ng/ml , respectively ( p greater than 0.05 ) . | tradename_of | {
"id": "C0700786",
"name": "msc",
"pos": [
50,
53
]
} | {
"id": "C0066814",
"name": "mss",
"pos": [
58,
61
]
} |
in the five patients who received msc every 8 hours , the findings paralleled those in the principal group , with no significant differences between msc and mss in cmax or cmin and a highly significant difference between the two in tmax . | tradename_of | {
"id": "C0700786",
"name": "msc",
"pos": [
34,
37
]
} | {
"id": "C0066814",
"name": "mss",
"pos": [
157,
160
]
} |
however , in this small group of patients , the auc with msc was significantly ( p = 0.04 ) greater than that with mss . | tradename_of | {
"id": "C0700786",
"name": "msc",
"pos": [
57,
60
]
} | {
"id": "C0066814",
"name": "mss",
"pos": [
115,
118
]
} |
there were no significant differences between msc and mss in pain scores or side effects . | tradename_of | {
"id": "C0700786",
"name": "msc",
"pos": [
46,
49
]
} | {
"id": "C0066814",
"name": "mss",
"pos": [
54,
57
]
} |
the authors evaluated regional skin temperatures of the foot following the administration of a variety of local anesthetic nerve blocks with either xylocaine ( lidocaine hydrochloride ) or sensorcaine ( bupivacaine hydrochloride ) . | tradename_of | {
"id": "C0699094",
"name": "xylocaine",
"pos": [
148,
157
]
} | {
"id": "C0546869",
"name": "lidocaine hydrochloride",
"pos": [
160,
183
]
} |
the in vitro and in vivo functionality of catapres-tts , a transdermal therapeutic system that delivers the alpha adrenergic receptor agonist clonidine , is discussed in terms of the drug transport kinetics and resultant plasma drug concentration profiles . | tradename_of | {
"id": "C0917969",
"name": "catapres-tts",
"pos": [
42,
54
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
142,
151
]
} |
clinical trials have clearly demonstrated the efficacy of recombinant human erythropoietin ( r-huepo ) ( epogen [ epoetin alfa ] ; amgen inc , thousand oaks , ca ) in the treatment of the anemia associated with end-stage renal disease ( esrd ) . | tradename_of | {
"id": "C0700704",
"name": "epogen",
"pos": [
105,
111
]
} | {
"id": "C0357126",
"name": "epoetin alfa",
"pos": [
114,
126
]
} |
one minor bleeding complication occurred among 10 patients on a regimen of coumadin ( crystalline warfarin sodium ) . | tradename_of | {
"id": "C0699129",
"name": "coumadin",
"pos": [
75,
83
]
} | {
"id": "C0376218",
"name": "warfarin sodium",
"pos": [
98,
113
]
} |
catapres-tts appears to be effective in patients with mild to moderate hypertension and may be a useful alternative to oral clonidine in patients experiencing drowsiness or dry mouth with the oral preparation . | tradename_of | {
"id": "C0917969",
"name": "catapres-tts",
"pos": [
0,
12
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
124,
133
]
} |
in conclusion , the good agreement between tp and man pressure readings is superior to the recently described agreement between tp and goldmann tonometer readings . | tradename_of | {
"id": "C2828181",
"name": "tp",
"pos": [
43,
45
]
} | {
"id": "C0183969",
"name": "tonometer",
"pos": [
144,
153
]
} |
general principles of treatment , after medical diagnosis and psychosocial evaluation , include hospitalization for acute episodes and physical disabilities , use of antabuse ( disulfiram ) in suitable cases , psychotherapy , and the use of social aids such as alcoholics anonymous . | tradename_of | {
"id": "C0591096",
"name": "antabuse",
"pos": [
166,
174
]
} | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
177,
187
]
} |
in the manometric study , the tono-pen had less mean error at high pressure ranges than either the mackay-marg tonometer or the pneumotonometer . | tradename_of | {
"id": "C2828181",
"name": "tono-pen",
"pos": [
30,
38
]
} | {
"id": "C0183969",
"name": "tonometer",
"pos": [
134,
143
]
} |
experimental conditions included presence or absence of intralipid iv fat emulsion , plastic bag or glass bottle storage container , and storage time of up to 48 hrs . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
56,
66
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
70,
82
]
} |
the airway response to inhaled atrovent and preservative free ipratropium bromide nebuliser solutions has been examined in a double blind study . | tradename_of | {
"id": "C0591130",
"name": "atrovent",
"pos": [
31,
39
]
} | {
"id": "C0700580",
"name": "ipratropium bromide",
"pos": [
62,
81
]
} |
atrovent nebuliser solution provoked a greater than 20 % fall in fev1 in five of the 30 subjects , whereas this did not occur after preservative free ipratropium bromide . | tradename_of | {
"id": "C0591130",
"name": "atrovent",
"pos": [
0,
8
]
} | {
"id": "C0700580",
"name": "ipratropium bromide",
"pos": [
150,
169
]
} |
a multicentric trial involving ten dermatological departments was conducted to evaluate the efficacy and tollerance of antibio-aberel ( an association of tretinoin and erythromycin base ) in 347 patients with persistant acne . | tradename_of | {
"id": "C1520048",
"name": "aberel",
"pos": [
127,
133
]
} | {
"id": "C0040845",
"name": "tretinoin",
"pos": [
154,
163
]
} |
an experimental investigation was carried out to produce and observe controlled , sequential changes in normal bladder urothelium of female dogs caused by thiotepa ( triethylene thiophosphoramide ) and adriamycin ( doxorubicin hydrochloride ) . | tradename_of | {
"id": "C0085752",
"name": "adriamycin",
"pos": [
202,
212
]
} | {
"id": "C0546861",
"name": "doxorubicin",
"pos": [
215,
226
]
} |
32 patients with stable angina pectoris who had been receiving a controlled-release formulation durules of isosorbide 5-mononitrate ( imdur ) 60 to 120 mg daily with concomitant beta-blocker therapy for at least 1 year were entered into a study to evaluate possible rebound phenomena from the abrupt withdrawal of isosorbide 5-mononitrate and to determine whether nitrate tolerance had developed . | tradename_of | {
"id": "C0590690",
"name": "imdur",
"pos": [
134,
139
]
} | {
"id": "C0064079",
"name": "isosorbide 5-mononitrate",
"pos": [
314,
338
]
} |
one should , however , be aware that diane contains only 2 mg cyproterone acetate ( cpa ) and a better effect would most probably have been obtained using a higher dosage of cpa . | tradename_of | {
"id": "C0057721",
"name": "diane",
"pos": [
37,
42
]
} | {
"id": "C0056855",
"name": "cpa",
"pos": [
174,
177
]
} |
the clinical efficacy of intravenous augmentin ( a formulation containing amoxycillin plus clavulanic acid ) was investigated in an open study in fifty-eight children with a mean age of 6 years ( range 1-15 years ) . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
37,
46
]
} | {
"id": "C0054066",
"name": "amoxycillin",
"pos": [
74,
85
]
} |
augmentin ( amoxycillin-clavulanic acid ) compared with amoxycillin alone in the treatment of urinary tract infections in the elderly . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
0,
9
]
} | {
"id": "C0054066",
"name": "amoxycillin-clavulanic acid",
"pos": [
12,
39
]
} |
myochrysine ( gold sodium thiomalate , gstm ) injections are the therapy of choice for children with refractory juvenile rheumatoid arthritis . | tradename_of | {
"id": "C0700008",
"name": "myochrysine",
"pos": [
0,
11
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
14,
36
]
} |
however , its activity was not markedly superior to that of either augmentin ( amoxicillin plus clavulanate ) or cefaclor . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
67,
76
]
} | {
"id": "C0054066",
"name": "amoxicillin",
"pos": [
79,
90
]
} |
oral and intravenous ( holoxan ) ifosfamide was applicated in a randomized sequence on days 1 and 3 at a dose of 1 g/m2 ( n = 12 ) and 2 g/m2 ( n = 6 ) . | tradename_of | {
"id": "C0733930",
"name": "holoxan",
"pos": [
23,
30
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
33,
43
]
} |
fifty four had an intravenous dose of 100 ml iohexol ( omnipaque ) and 33 had 50 ml iohexol . | tradename_of | {
"id": "C0729203",
"name": "omnipaque",
"pos": [
55,
64
]
} | {
"id": "C0022005",
"name": "iohexol",
"pos": [
84,
91
]
} |
the metabolic effects of an injectable contraceptive , depo-provera ( medroxyprogesterone acetate ) , an oral contraceptive pill containing 50 micrograms ethinyl estradiol and 500 micrograms norgestrel and a control group ( not on contraceptives ) were compared in 3 groups , each comprising 32 women . | tradename_of | {
"id": "C0699700",
"name": "depo-provera",
"pos": [
55,
67
]
} | {
"id": "C0065864",
"name": "medroxyprogesterone acetate",
"pos": [
70,
97
]
} |
[ effect of atrovent ( ipratropium bromide ) on the mechanics of respiration in patients with chronic obstructive pulmonary disease ] . | tradename_of | {
"id": "C0591130",
"name": "atrovent",
"pos": [
12,
20
]
} | {
"id": "C0700580",
"name": "ipratropium bromide",
"pos": [
23,
42
]
} |
motrin ( ibuprofen ) , a potent inhibitor of prostaglandin synthetase , was tested in women and men for treatment of recurrences of genital herpes . | tradename_of | {
"id": "C0699203",
"name": "motrin",
"pos": [
0,
6
]
} | {
"id": "C0020740",
"name": "ibuprofen",
"pos": [
9,
18
]
} |
she was discovered after recovering partial voluntary lower extremity function under the influence of pentothal ( thiopental sodium ) . | tradename_of | {
"id": "C0600350",
"name": "pentothal",
"pos": [
102,
111
]
} | {
"id": "C0936073",
"name": "thiopental",
"pos": [
114,
124
]
} |
a review of adverse experience reports submitted to the manufacturer suggests that cylert ( brand of pemoline ) has a limited potential for abuse or dependence . | tradename_of | {
"id": "C0719594",
"name": "cylert",
"pos": [
83,
89
]
} | {
"id": "C0030800",
"name": "pemoline",
"pos": [
101,
109
]
} |
the unique biological properties and therapeutic efficacy of the podophyllotoxin derivatives , vumon ( vm26 , teniposide ) and vepesid ( vp16-213 , etoposide ) , are stimulating the interest of both laboratory and clinical researchers . | tradename_of | {
"id": "C0728981",
"name": "vumon",
"pos": [
95,
100
]
} | {
"id": "C0039512",
"name": "teniposide",
"pos": [
110,
120
]
} |
one hundred and thirty-five consecutive patients referred for urography were monitored electrocardiographically before , during and after injection of 60 ml hypaque 45 % ( sodium diatrizoate 45 % w/v ) over 60 seconds . | tradename_of | {
"id": "C0813724",
"name": "hypaque",
"pos": [
157,
164
]
} | {
"id": "C0012007",
"name": "sodium diatrizoate",
"pos": [
172,
190
]
} |
the oxidation rate of 14c-intralipid was linearly related to net whole body fat oxidation calculated using indirect calorimetry ( r = -0.90 ; p less than 0.001 ) suggesting that the fat emulsion was oxidized in a similar manner to endogenous lipids . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
26,
36
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
182,
194
]
} |
regimens containing adriamycin ( doxorubicin hydrochloride ) appeared to prolong the survival of patients with epithelial-type tumors . | tradename_of | {
"id": "C0085752",
"name": "adriamycin",
"pos": [
20,
30
]
} | {
"id": "C0546861",
"name": "doxorubicin hydrochloride",
"pos": [
33,
58
]
} |
splenic leukocytes or serum was removed from mice which had been inoculated previously 1 to 4 or 5 times with p. berghei and cured 1 to 4 or 5 times with fansidar ( pyrimethamine plus sulfadoxine ) and transferred to syngeneic recipients 1 or 2 days before parasite challenge . | tradename_of | {
"id": "C0060061",
"name": "fansidar",
"pos": [
154,
162
]
} | {
"id": "C0700599",
"name": "pyrimethamine",
"pos": [
165,
178
]
} |
the procedure was performed under light general anaesthesia , using ketalar ( ketamine hydrochloride ) in a minimal dosage . | tradename_of | {
"id": "C0022613",
"name": "ketalar",
"pos": [
68,
75
]
} | {
"id": "C0700541",
"name": "ketamine hydrochloride",
"pos": [
78,
100
]
} |
twenty patients with stage iiim0 ( t3n2 ) non-small cell lung cancer were treated with vindesine , etoposide , and platinol ( cisplatin ) ( eletop ) chemotherapy in an attempt to decrease tumor size and increase resectability and survival . | tradename_of | {
"id": "C0699666",
"name": "platinol",
"pos": [
115,
123
]
} | {
"id": "C0008838",
"name": "cisplatin",
"pos": [
126,
135
]
} |
retinal cotton-wool patches , not previously observed in bone marrow recipients , have been reported in three patients who received sandimmun ( cyclosporine ) as prophylaxis for graft-versus-host-disease after bone marrow transplantation . | tradename_of | {
"id": "C0699604",
"name": "sandimmun",
"pos": [
132,
141
]
} | {
"id": "C0010592",
"name": "cyclosporine",
"pos": [
144,
156
]
} |
in both of these studies the ecotrin capsule induced less stomach damage than did any of the other aspirin products tested . | tradename_of | {
"id": "C0699274",
"name": "ecotrin",
"pos": [
29,
36
]
} | {
"id": "C0004057",
"name": "aspirin products",
"pos": [
99,
115
]
} |
three cardiac surgical patients with acute postoperative renal failure were treated with a constant infusion of furosemide ( lasix ) after furosemide given in bolus proved ineffective . | tradename_of | {
"id": "C0699992",
"name": "lasix",
"pos": [
125,
130
]
} | {
"id": "C0016860",
"name": "furosemide",
"pos": [
139,
149
]
} |
recent reports have shown that decadron ( dexamethasone ; merck sharp & dohme , west point , pa ) has a significant antiemetic effect on cisplatin-induced vomiting . | tradename_of | {
"id": "C0740057",
"name": "decadron",
"pos": [
31,
39
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
42,
55
]
} |
a study was designed to establish a dose-response curve for pergonal ( human menopausal gonadotrophin ) and to compare its efficacy in inducing superovulation with commercial fsh-p . | tradename_of | {
"id": "C0700188",
"name": "pergonal",
"pos": [
60,
68
]
} | {
"id": "C0025326",
"name": "human",
"pos": [
71,
76
]
} |
pilot in vitro studies demonstrated that nystatin combined with silvadene ( silver sulfadiazine 1 % [ marion laboratories , inc. , kansas city mo . ] ) or furacin in a 1:1 ratio was equally effective against candida albicans and atcc strains of staphylococcus aureus , pseudomonas aeruginosa , and escherichia coli , but sulfamylon ( winthrop pharmaceuticals , winthrop , n.y. ) combined with nystatin demonstrated an antagonistic response . | tradename_of | {
"id": "C0728768",
"name": "silvadene",
"pos": [
64,
73
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
76,
95
]
} |
as part of a commitment to fully automate the manufacture of a lyophilized dosage form of azactam ( aztreonam for injection ) , an automated solution batching procedure was developed . | tradename_of | {
"id": "C0699281",
"name": "azactam",
"pos": [
90,
97
]
} | {
"id": "C0004521",
"name": "aztreonam",
"pos": [
100,
109
]
} |
we developed such a model where prior exposure to non-toxic levels of the pesticide kepone ( chlordecone ) results in a 67-fold amplification of ccl4 lethality in experimental animals . | tradename_of | {
"id": "C0878176",
"name": "kepone",
"pos": [
84,
90
]
} | {
"id": "C0022562",
"name": "chlordecone",
"pos": [
93,
104
]
} |
the brand metronidazole ( flagyl , may & baker , kenya ltd. ) , the generic metronidazole ( metrozol , cosmos ltd. , nairobi , kenya ) , the brand tinidazole ( fasigyn , pfizer laboratories ltd. ) and the generic tinidazole ( tynazole laboratory and allied equipments , kenya ltd ) . | tradename_of | {
"id": "C0591480",
"name": "fasigyn",
"pos": [
160,
167
]
} | {
"id": "C0040263",
"name": "tinidazole",
"pos": [
213,
223
]
} |
to test the efficacy and safety of amoxycillin/clavulanate ( augmentin ) , 102 hospital patients with laparoscopically confirmed acute salpingitis were treated with parenteral amoxycillin/clavulanate ( 1.2 g qid for three days ) followed by oral amoxycillin/clavulanate ( two tablets of 625 mg tid for a further six days ) . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
61,
70
]
} | {
"id": "C0054066",
"name": "amoxycillin/clavulanate",
"pos": [
246,
269
]
} |
forty patients were randomized to receive either augmentin ( 1,000 mg amoxycillin +250 mg clavulanate ) tds or ciprofloxacin ( 500 mg ) bd . | tradename_of | {
"id": "C0591132",
"name": "augmentin",
"pos": [
49,
58
]
} | {
"id": "C0054066",
"name": "amoxycillin",
"pos": [
70,
81
]
} |
the absorption of novantrone ( mitozantrone ) , adriamycin ( doxorubicin hydrochloride ) , cerubidin ( daunorubicin ) and methotrexate to 0.2-microm endotoxin-retentive end-line filters was studied under simulated infusion conditions . | tradename_of | {
"id": "C0085752",
"name": "adriamycin",
"pos": [
48,
58
]
} | {
"id": "C0546861",
"name": "doxorubicin",
"pos": [
61,
72
]
} |
thirteen new analogs of 2,4-diamino-5 ( p-chlorophenyl ) -6-ethylpyrimidine ( daraprim , pyrimethamine ) in which the alph position of the 6-ethyl substituent was modified were prepared . | tradename_of | {
"id": "C0591326",
"name": "daraprim",
"pos": [
78,
86
]
} | {
"id": "C0034283",
"name": "pyrimethamine",
"pos": [
89,
102
]
} |
the comparative prophylactic effectiveness of oral treatment with ribavirin ( 1-beta-d-ribofuranosyl-1,2,4 , triazole-3-carboxamide ; virazole ) and amantadine hydrochloride against artificially induced infection with influenza a virus was evaluated in 29 seronegative men who received ribavirin capsules ( 200 mg ) three times daily , placebo capsules three times daily , or amantadine capsules ( 100 mg ) twice daily . | tradename_of | {
"id": "C1622085",
"name": "virazole",
"pos": [
134,
142
]
} | {
"id": "C0035525",
"name": "ribavirin",
"pos": [
286,
295
]
} |
the two kallikreins were separated by affinity chromatography using trasylol ( aprotinin ) covalently bound to sepharose . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
68,
76
]
} | {
"id": "C0003641",
"name": "aprotinin",
"pos": [
79,
88
]
} |
this paper describes the effect of the amino acid mixture freamine ii on the physical stability of intralipid fat emulsion . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
99,
109
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
110,
122
]
} |
the effects of subarachnoid injection of conray ( methylglucamine iothalamate ) and its dimer ( methylglucamine locarmate ) in various concentrations were compared using electrophysiological monitors of the cortical evoked response ( cer ) and the h-reflex . | tradename_of | {
"id": "C0719484",
"name": "conray",
"pos": [
41,
47
]
} | {
"id": "C0022033",
"name": "methylglucamine iothalamate",
"pos": [
50,
77
]
} |
trasylol ( kunitz basic pancreatic trypsin inhibitor ) acted more strongly on bound scrosin than on soluble acrosin , but soya-bean trypsin inhibitor acted more strongly on soluble acrosin . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
0,
8
]
} | {
"id": "C0003641",
"name": "basic pancreatic trypsin inhibitor",
"pos": [
18,
52
]
} |
the relationship between intralipid fat emulsion and the binding of bilirubin to protein and cells was studied in vitro and in vivo . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
25,
35
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
36,
48
]
} |
for up to one year , 22 patients with occular hypertension or glaucoma wore a seven-day sustained release device ( ocusert ) containing pilocarpine with acceptable retention and no important side-effects . | tradename_of | {
"id": "C0028870",
"name": "ocusert",
"pos": [
115,
122
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
136,
147
]
} |
in vitro antibiotic disc sensitivity tests indicated that rovamycin ( solubilized spiramycin ) may be recommended for turkey mycoplasmosis . | tradename_of | {
"id": "C0878223",
"name": "rovamycin",
"pos": [
58,
67
]
} | {
"id": "C0037962",
"name": "spiramycin",
"pos": [
82,
92
]
} |
in case of intravenous administration of valium using ampoule solutions diazepam and in addition a second active substance are applicated . | tradename_of | {
"id": "C0699187",
"name": "valium",
"pos": [
41,
47
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
72,
80
]
} |
preliminary data obtained in the ambit of anturan reinfarction italian study ( aris ) show that , in postmyocardial infarction , reduced platelet survival time occurred in hyperbetalipoproteinemic patients treated with placebo , but not in the group of patients treated with sulfinpyrazone ( interaction between treatment and lipemic level is at p approximately equal to 0.1 ) . | tradename_of | {
"id": "C0591099",
"name": "anturan",
"pos": [
42,
49
]
} | {
"id": "C0038742",
"name": "sulfinpyrazone",
"pos": [
275,
289
]
} |
twenty-four cases of hemangiomas of various sizes in the oral cavity and lips were treated with local injections of a sclerosing agent ( 3 % sotradecol - sodium tetradecyl sulfate ) . | tradename_of | {
"id": "C0087006",
"name": "sotradecol",
"pos": [
141,
151
]
} | {
"id": "C0037556",
"name": "sodium",
"pos": [
154,
160
]
} |
[ on the determination of antimalarials in body fluids and excretions . 4. field test on the quantitative demonstration of daraprim ( pyrimethamine ) in the urine ] . | tradename_of | {
"id": "C0591326",
"name": "daraprim",
"pos": [
123,
131
]
} | {
"id": "C0034283",
"name": "pyrimethamine",
"pos": [
134,
147
]
} |
a precipitate was in fact found in dextrose injections containing valium and stesolid whereas diazepam a.l . was not only slightly cloudy . | tradename_of | {
"id": "C0699187",
"name": "valium",
"pos": [
66,
72
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
94,
102
]
} |
an interference microscopic method is described which allows quantitative measurements of the inhibiting effect of the di-sodium salt of 1,3-bis ( 3-carboxy-chroman-5-yl-oxy ) -2-hydroxypropand ( cromoglicinic acid ; intal ; dscg ) on the degranulation of mast cells in vitro induced by polymixin b and compound 48/80 . | tradename_of | {
"id": "C0591652",
"name": "intal",
"pos": [
217,
222
]
} | {
"id": "C0012694",
"name": "dscg",
"pos": [
225,
229
]
} |
a report of the results of a multicenter study including 4686 patients concerning the therapeutic value of trasylol ( aprotinin ) in traumatic shock . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
107,
115
]
} | {
"id": "C0003641",
"name": "aprotinin",
"pos": [
118,
127
]
} |
in the animals receiving allografts , the trachea was exchanged between paired animals which were preoperatively immunosuppressed with imuran ( azathioprine ) and postoperatively given decadron ( dexamethasone ) . | tradename_of | {
"id": "C0740057",
"name": "decadron",
"pos": [
185,
193
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
196,
209
]
} |
the role of the nurse in intravenous dissociative anesthesia : valium ( diazepam ) is the key to ketamine . | tradename_of | {
"id": "C0699187",
"name": "valium",
"pos": [
63,
69
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
72,
80
]
} |
the soluble corticosteroid , solumedrol ( methyl prednisolone sodium succinate ) was added to the medium , at concentrations including the range expected during rejection episodes following organ transplantation ( 3.8 x 10 ( -9 ) m-3.8 x 10 ( -6 ) m ) . | tradename_of | {
"id": "C0701466",
"name": "solumedrol",
"pos": [
29,
39
]
} | {
"id": "C0700546",
"name": "methyl prednisolone sodium succinate",
"pos": [
42,
78
]
} |