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[ inhibitory effect of intal ( disodium cromoglycate ) eye drops on ocular provocation for japanese cedar pollinosis ] . | tradename_of | {
"id": "C0591652",
"name": "intal",
"pos": [
23,
28
]
} | {
"id": "C0012694",
"name": "disodium cromoglycate",
"pos": [
31,
52
]
} |
topical formulations containing a new chemical entity , the ultraviolet a absorber parsol 1789 ( butyl methoxydibenzoylmethane ) , were evaluated as agents for protecting human skin against ultraviolet a ( uva ) radiation . | tradename_of | {
"id": "C0070124",
"name": "parsol 1789",
"pos": [
83,
94
]
} | {
"id": "C0097513",
"name": "butyl methoxydibenzoylmethane",
"pos": [
97,
126
]
} |
choledyl , theo-dur and slo-bid appear to have absorption characteristics which , if given twice daily , would maintain therapeutic plasma concentrations of theophylline between 10 and 20 micrograms/ml in the dog . | tradename_of | {
"id": "C0700842",
"name": "slo-bid",
"pos": [
24,
31
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
157,
169
]
} |
in order to determine the relative effectiveness of several antiandrogens , megace ( megestrol acetate ) , flutamide and ru23908 were administered in optimal doses ( 20 mg./kg. , 10 mg./kg . and 20 mg./kg . ) subcutaneously daily to adult male sprague-dawley rats for 14 and 28 days and their effects on ventral prostate , seminal vesicles , and serum testosterone were determined . | tradename_of | {
"id": "C0700004",
"name": "megace",
"pos": [
76,
82
]
} | {
"id": "C0065879",
"name": "megestrol acetate",
"pos": [
85,
102
]
} |
utilization of intralipid in septic rats : effects of sepsis on the clearance of exogenous fat emulsion from various organs . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
15,
25
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
91,
103
]
} |
dexamethasone 0.1 % , benzalconium chloride 0.01 % , and chlorobutanol 0.2 % did not significantly inhibit wound healing , while spersadex ( dexamethasone 0.1 % + benzalconium chloride 0.01 % ) and totocortin ( dexamethasone 0.1 + chlorobutanol 0.2 % ) did . | tradename_of | {
"id": "C0525106",
"name": "spersadex",
"pos": [
129,
138
]
} | {
"id": "C0011777",
"name": "dexamethasone",
"pos": [
211,
224
]
} |
a randomized , double-blind , placebo controlled study to investigate the long-term effect of cyclospasmol ( cyclandelate ) on the abnormal permeability of the blood-retinal barrier was performed in 26 patients with insulin-dependent diabetes mellitus for at least 1 year and minimal retinopathy . | tradename_of | {
"id": "C0795734",
"name": "cyclospasmol",
"pos": [
94,
106
]
} | {
"id": "C0010525",
"name": "cyclandelate",
"pos": [
109,
121
]
} |
in a randomized crossover study on twelve healthy test subjects , the plasma concentration of isosorbide-5-nitrate ( is-5-n ) after oral administration of 40 mg is-5-n daily from two standard preparations ( two tablets ismo 20 or corangin 20 ) and two sustained release preparations with 40 mg or 60 mg is-5-n ( one tablet corangin 40 or corangin 60 ) once a day was determined . | tradename_of | {
"id": "C0699156",
"name": "ismo",
"pos": [
219,
223
]
} | {
"id": "C0064079",
"name": "is-5-n",
"pos": [
303,
309
]
} |
mistletoe lectins and viscotoxins , which up to now have been isolated only from plant material , were detected and quantitatively determined in the mistletoe preparation iscador and in a fermented mistletoe extract . | tradename_of | {
"id": "C0063891",
"name": "iscador",
"pos": [
171,
178
]
} | {
"id": "C1166209",
"name": "mistletoe extract",
"pos": [
198,
215
]
} |
the influence of disodium 2-mercaptoethane sulfonate disulfide ( mesna , uromitexan ) and sodium 2-mercaptoethane sulfonate ( dimesna ) on the carrier mediated exchange of 35s-sulfate in human red blood cells was investigated in vitro in order to contribute to the understanding of pharmakokinetics and organospecific action of mesna . | tradename_of | {
"id": "C0678115",
"name": "uromitexan",
"pos": [
73,
83
]
} | {
"id": "C0000294",
"name": "mesna",
"pos": [
328,
333
]
} |
it is concluded that treatment with phenytoin during use of norplant subdermal implants enhances the metabolism of lng to an extent where the contraceptive efficacy is endangered . | tradename_of | {
"id": "C1145675",
"name": "norplant",
"pos": [
60,
68
]
} | {
"id": "C0023566",
"name": "lng",
"pos": [
115,
118
]
} |
[ effect of cuprenil ( penicillamine ) on peripheral blood lymphocytes and their t and b populations in patients with rheumatoid arthritis ] . | tradename_of | {
"id": "C0699484",
"name": "cuprenil",
"pos": [
12,
20
]
} | {
"id": "C0030817",
"name": "penicillamine",
"pos": [
23,
36
]
} |
ritalin ( methylphenidate hydrochloride ) , benzedrine ( amphetamine sulfate ) , and dexedrine ( dextroamphetamine sulfate ) were examined for oncogenicity using a serial line of fischer rat embryo cells , which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents . | tradename_of | {
"id": "C0728759",
"name": "ritalin",
"pos": [
0,
7
]
} | {
"id": "C0700545",
"name": "methylphenidate hydrochloride",
"pos": [
10,
39
]
} |
ritalin ( methylphenidate hydrochloride ) , benzedrine ( amphetamine sulfate ) , and dexedrine ( dextroamphetamine sulfate ) were examined for oncogenicity using a serial line of fischer rat embryo cells , which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents . | tradename_of | {
"id": "C0591355",
"name": "dexedrine",
"pos": [
85,
94
]
} | {
"id": "C0011810",
"name": "dextroamphetamine sulfate",
"pos": [
97,
122
]
} |
five studies of the carcinogenicity of the chlorinated pesticide kepone ( chlordecone ) in animals were reviewed . | tradename_of | {
"id": "C0878176",
"name": "kepone",
"pos": [
65,
71
]
} | {
"id": "C0022562",
"name": "chlordecone",
"pos": [
74,
85
]
} |
a neutralizer system was developed and validated for use in the in vitro bactericidal evaluation of three commonly used antiseptics , namely , hibiclens ( 4 % [ wt/vol ] chlorhexidine gluconate ) , betadine ( 7.5 % [ wt/vol ] povidone-iodine ) , and phisohex ( 3 % [ wt/vol ] hexachlorophene ) . | tradename_of | {
"id": "C0699524",
"name": "betadine",
"pos": [
198,
206
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
226,
241
]
} |
a neutralizer system was developed and validated for use in the in vitro bactericidal evaluation of three commonly used antiseptics , namely , hibiclens ( 4 % [ wt/vol ] chlorhexidine gluconate ) , betadine ( 7.5 % [ wt/vol ] povidone-iodine ) , and phisohex ( 3 % [ wt/vol ] hexachlorophene ) . | tradename_of | {
"id": "C0308205",
"name": "phisohex",
"pos": [
250,
258
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
276,
291
]
} |
twenty patients with disabling disorders of keratinization were treated with tigason ( etretinate , ro 10-9359 ) , an oral aromatic retinoid , and the clinical responses and the effects on the skin were monitored . | tradename_of | {
"id": "C0729231",
"name": "tigason",
"pos": [
77,
84
]
} | {
"id": "C0015137",
"name": "etretinate",
"pos": [
87,
97
]
} |
eighteen patients with darier 's disease were treated for at least 3 months with the oral aromatic retinoid tigason ( etretinate , ro 10-9359 ) . | tradename_of | {
"id": "C0729231",
"name": "tigason",
"pos": [
108,
115
]
} | {
"id": "C0015137",
"name": "etretinate",
"pos": [
118,
128
]
} |
in the anturane reinfarction italian study the trend of some specific and quantitative haemostatic parameters is being investigated in different series of patients balanced for sulfinpyrazone and placebo . | tradename_of | {
"id": "C0591099",
"name": "anturane",
"pos": [
7,
15
]
} | {
"id": "C0038742",
"name": "sulfinpyrazone",
"pos": [
177,
191
]
} |
trimethylmethoxyphenyl-retinoic acid ( tmmp-retinoic acid , ro 10-1670 ) is the main metabolite of the aromatic retinoid ro 10-9359 ( tigason , etretinate ) , which is now in clinical use . | tradename_of | {
"id": "C0729231",
"name": "tigason",
"pos": [
134,
141
]
} | {
"id": "C0015137",
"name": "etretinate",
"pos": [
144,
154
]
} |
conray ( meglumine iothalamate ) , the contrast media frequently used in shuntograms for diagnosing malfunctioning ventriculo-peritoneal shunts , will occasionally cause severe muscular spasms and seizures . | tradename_of | {
"id": "C0719484",
"name": "conray",
"pos": [
0,
6
]
} | {
"id": "C0022033",
"name": "meglumine iothalamate",
"pos": [
9,
30
]
} |
four normally cycling women received an iv injection of 20 mg premarin ( conjugated estrogens equivalent to 20 mg estrone sulfate ) on the seventh day of two consecutive cycles ; | tradename_of | {
"id": "C0699710",
"name": "premarin",
"pos": [
62,
70
]
} | {
"id": "C0014938",
"name": "conjugated estrogens",
"pos": [
73,
93
]
} |
women with norplant had higher fli than those with norplant-2 and women who became pregnant had lower fli than those who did not . | tradename_of | {
"id": "C1145675",
"name": "norplant-2",
"pos": [
51,
61
]
} | {
"id": "C0023566",
"name": "fli",
"pos": [
102,
105
]
} |
it is suggested that norplant-2 implants have a lower rate of release of levonorgestrel than norplant implants . | tradename_of | {
"id": "C1145675",
"name": "norplant-2",
"pos": [
21,
31
]
} | {
"id": "C0023566",
"name": "levonorgestrel",
"pos": [
73,
87
]
} |
human immunodeficiency virus ( hiv ) , the etiological agent of the acquired immunodeficiency syndrome ( aids ) , was treated with either betadine ( povidone-iodine ) solution or betadine surgical scrub . | tradename_of | {
"id": "C0699524",
"name": "betadine",
"pos": [
138,
146
]
} | {
"id": "C0032857",
"name": "povidone-iodine",
"pos": [
149,
164
]
} |
a controversy exists with regard to the relative efficacy of two preparations of silver sulfadiazine ( agsd ) , silvadene and flint 's silver sulfadiazine cream . | tradename_of | {
"id": "C0728768",
"name": "silvadene",
"pos": [
112,
121
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
135,
154
]
} |
however , when s aureus-infected rat burn wounds were treated with these antimicrobial creams over a period of ten days , silvadene significantly lowered bacterial counts , whereas results after treatment with flint 's silver sulfadiazine cream were no different from those of the control group , which received no treatment . | tradename_of | {
"id": "C0728768",
"name": "silvadene",
"pos": [
122,
131
]
} | {
"id": "C0037134",
"name": "silver sulfadiazine",
"pos": [
219,
238
]
} |
in the years 1971 to 1973 the therapeutic effect of trasylol ( aprotinin isolated from bovine organs ) in the treatment of the traumatic shock was investigated in a controlled field study at 31 hospitals in northern germany . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
52,
60
]
} | {
"id": "C0003641",
"name": "aprotinin",
"pos": [
63,
72
]
} |
the fractional removal rate of exogenous tg , determined by the intravenous fat tolerance test ( ivftt ) with the intralipid fat emulsion , was not significantly changed . | tradename_of | {
"id": "C0733854",
"name": "intralipid",
"pos": [
114,
124
]
} | {
"id": "C0304483",
"name": "fat emulsion",
"pos": [
125,
137
]
} |
androcur ( cyproterone acetate ) is an antiandrogen that is capable of competitively inhibiting androgens in the organism . | tradename_of | {
"id": "C0699709",
"name": "androcur",
"pos": [
0,
8
]
} | {
"id": "C0056855",
"name": "cyproterone acetate",
"pos": [
11,
30
]
} |
large scale , multiclinic evaluations of vidarabine ( ara-a , vira a , adenine arabinoside ) for treating herpetic keratitis have been conducted as double-blind studies ( 169 patients ) in comparison with idu and open studies ( 146 patients ) . | tradename_of | {
"id": "C0699565",
"name": "vira a",
"pos": [
62,
68
]
} | {
"id": "C0042646",
"name": "adenine",
"pos": [
71,
78
]
} |
the objectives of this open-labeled , multiple-dose , three-way-crossover trial were to evaluate the safety and tolerance of zidovudine ( retrovir ) oral syrup and to assess the bioequivalence of this formulation relative to zidovudine solution and capsule formulations in human immunodeficiency virus-infected patients . | tradename_of | {
"id": "C0699576",
"name": "retrovir",
"pos": [
138,
146
]
} | {
"id": "C0043474",
"name": "zidovudine",
"pos": [
225,
235
]
} |
the occurrence of extraspinal tendon and ligament calcification has been emphasized following long-term therapy with etretinate ( tegison , tigason ) , but the relationship between etretinate and spinal hyperostosis is less certain , there being a need for a long-term , prospective , appropriately controlled investigation of patients receiving etretinate . | tradename_of | {
"id": "C0723623",
"name": "tegison",
"pos": [
130,
137
]
} | {
"id": "C0015137",
"name": "etretinate",
"pos": [
346,
356
]
} |
the occurrence of extraspinal tendon and ligament calcification has been emphasized following long-term therapy with etretinate ( tegison , tigason ) , but the relationship between etretinate and spinal hyperostosis is less certain , there being a need for a long-term , prospective , appropriately controlled investigation of patients receiving etretinate . | tradename_of | {
"id": "C0729231",
"name": "tigason",
"pos": [
140,
147
]
} | {
"id": "C0015137",
"name": "etretinate",
"pos": [
346,
356
]
} |
norplant-2 contraceptive implants consist of two silastic rods in which levonorgestrel has been incorporated with the polymer . | tradename_of | {
"id": "C1145675",
"name": "norplant-2",
"pos": [
0,
10
]
} | {
"id": "C0023566",
"name": "levonorgestrel",
"pos": [
72,
86
]
} |
the protective effect of the narcoanalgetics , viadril ( hydroxydione sodium succinate ) and administered intraperitoneally in doses of 5 and 20 mg/kg was studied in the experiment on 146 pregnant noninbred white rats with simulated hemic hypoxia in the late pregnancy ( the 19th day ) . | tradename_of | {
"id": "C0042621",
"name": "viadril",
"pos": [
47,
54
]
} | {
"id": "C2697635",
"name": "hydroxydione sodium",
"pos": [
57,
76
]
} |
the causes of the shock were administrations of antibiotics , novocain ( procaine hydrochloride ) , glucose , radiopaque agents , plasma-substituting solutions , protein hydrolysates , and other substances . | tradename_of | {
"id": "C1608242",
"name": "novocain",
"pos": [
62,
70
]
} | {
"id": "C0358490",
"name": "procaine hydrochloride",
"pos": [
73,
95
]
} |
after 9 months treatment patients were randomised to a 12 month double-blind cross-over trial comparing diane plus 25 mg ca with diane plus placebo , to test the efficacy of low-dose ca as maintenance therapy . | tradename_of | {
"id": "C0057721",
"name": "diane",
"pos": [
104,
109
]
} | {
"id": "C0056855",
"name": "ca",
"pos": [
183,
185
]
} |
to evaluate the effect of bicitra ( willen drug company , baltimore , maryland ) , a commercial preparation of sodium citrate and metoclopramide , on gastric contents 150 elective outpatients allocated into six groups with 25 patients in each group were studied . | tradename_of | {
"id": "C0718938",
"name": "bicitra",
"pos": [
26,
33
]
} | {
"id": "C0142825",
"name": "sodium citrate",
"pos": [
111,
125
]
} |
this memorandum reviews the results of research undertaken in animals and human subjects on the implantable contraceptive , norplant , and where relevant , its components , levonorgestrel and silastic . | tradename_of | {
"id": "C1145675",
"name": "norplant",
"pos": [
124,
132
]
} | {
"id": "C0023566",
"name": "levonorgestrel",
"pos": [
173,
187
]
} |
in the present study 27 post-myocardial infarction patients were treated with persantin capsules ( depot-kapseln , sustained release form ) , containing 200 mg dipyridamole , b.i.d . over a period of 3 weeks . | tradename_of | {
"id": "C0700020",
"name": "persantin",
"pos": [
78,
87
]
} | {
"id": "C0012582",
"name": "dipyridamole",
"pos": [
160,
172
]
} |
in a prospective randomized study 8 patients were peroperatively allocated to closure of ureterotomies with a fibrin adhesive ( tisseel ) and 8 patients to closure with dexon sutures to evaluate whether the duration of postoperative urinary leakage could be diminished by the use of fibrin adhesive . | tradename_of | {
"id": "C0947703",
"name": "tisseel",
"pos": [
128,
135
]
} | {
"id": "C0016004",
"name": "fibrin adhesive",
"pos": [
283,
298
]
} |
capoten ( captopril ) treatment was conducted in 39 patients with essential hypertension of stage iia-iib and in 4 patients with idiopathic hyperplasia of the adrenals . | tradename_of | {
"id": "C0591224",
"name": "capoten",
"pos": [
0,
7
]
} | {
"id": "C0006938",
"name": "captopril",
"pos": [
10,
19
]
} |
a review of the characteristics of mitomycin ( mutamycin ) for injection therapy and of patients with superficial bladder cancer facilitates examining mitomycin from the standpoint of cost effectiveness . | tradename_of | {
"id": "C0702051",
"name": "mutamycin",
"pos": [
47,
56
]
} | {
"id": "C0002475",
"name": "mitomycin",
"pos": [
151,
160
]
} |
the effect of preinduction cervical ripening with prepidil , a commercially prepared prostaglandin e2 gel ( 0.5 mg ) , on the outcome of induction of labor with intravenous oxytocin was investigated . | tradename_of | {
"id": "C0592000",
"name": "prepidil",
"pos": [
50,
58
]
} | {
"id": "C0012472",
"name": "prostaglandin e2",
"pos": [
85,
101
]
} |
tylenol ( acetaminophen ) could reproduce these effects only at much higher ( greater than or equal to 10-fold ) concentrations . | tradename_of | {
"id": "C0699142",
"name": "tylenol",
"pos": [
0,
7
]
} | {
"id": "C0000970",
"name": "acetaminophen",
"pos": [
10,
23
]
} |
data submitted to the fda for theo-24 ( searle ) suggest slow but incomplete absorption in single-dose studies , and multiple-dose studies confirm incomplete absorption relative to plain theophylline tablets . | tradename_of | {
"id": "C0700825",
"name": "theo-24",
"pos": [
30,
37
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
187,
199
]
} |
[ treatment of some dermatoses caused by yeast fungi ( moniliasis of the pyodermitis vegetans type , intertrigo , onyxis and perionyxis ) with the new fungicide : mycostatin or nystatin ] . | tradename_of | {
"id": "C0699477",
"name": "mycostatin",
"pos": [
163,
173
]
} | {
"id": "C0028741",
"name": "nystatin",
"pos": [
177,
185
]
} |
the antisecretory properties of pepto-bismol ( pb ) and its active ingredient , bismuth subsalicylate ( bss ) , were studied in ligated ( rabbit and pig ) and unligated ( rat ) intestinal-segment models . | tradename_of | {
"id": "C0136074",
"name": "pepto-bismol",
"pos": [
32,
44
]
} | {
"id": "C0053792",
"name": "bismuth subsalicylate",
"pos": [
80,
101
]
} |
finally , when pb or bss was administered 30 minutes before intestinal inoculation with arachidonic acid in a rat model of inflammatory diarrhea , the percentages of inhibition of fluid accumulation ranged , in a dose-responsive fashion , from 16 % to 113 % for pb and from 25 % to 111 % for bss . | tradename_of | {
"id": "C0136074",
"name": "pb",
"pos": [
15,
17
]
} | {
"id": "C0053792",
"name": "bss",
"pos": [
292,
295
]
} |
pepto-bismol , which contains bismuth subsalicylate ( bss ) as the active ingredient , has been marketed in the united states for more than 80 years . | tradename_of | {
"id": "C0136074",
"name": "pepto-bismol",
"pos": [
0,
12
]
} | {
"id": "C0053792",
"name": "bismuth subsalicylate",
"pos": [
30,
51
]
} |
the maximal daily dose of pepto-bismol ( 4.2 g of bss ) results in peak concentrations of salicylate in plasma considerably below the level of salicylate toxicity . | tradename_of | {
"id": "C0136074",
"name": "pepto-bismol",
"pos": [
26,
38
]
} | {
"id": "C0053792",
"name": "bss",
"pos": [
50,
53
]
} |
extended dosing of pepto-bismol ( 3.14 g of bss/d ) for up to 6 weeks produced a mean concentration of bismuth in blood of 16.1 +/- 7.9 ng/g , considerably below concentrations in blood that have been reported to cause neurotoxicity . | tradename_of | {
"id": "C0136074",
"name": "pepto-bismol",
"pos": [
19,
31
]
} | {
"id": "C0053792",
"name": "bss",
"pos": [
44,
47
]
} |
at memorial hospital ( ormond beach , fl ) , routine qa screening detected a potential problem with the use of halcion ( triazolam ) . | tradename_of | {
"id": "C0733624",
"name": "halcion",
"pos": [
111,
118
]
} | {
"id": "C0040879",
"name": "triazolam",
"pos": [
121,
130
]
} |
photofrin and hematoporphyrin derivatives were shown to contain different quantities of monomer , dimer and other oligomeric porphyrins . | tradename_of | {
"id": "C0729236",
"name": "photofrin",
"pos": [
0,
9
]
} | {
"id": "C0121300",
"name": "hematoporphyrin derivatives",
"pos": [
14,
41
]
} |
medium containing sulfamylon ( mafenide acetate , 0.85 % ) , polysporin ( polymyxin b sulfate , 1 x 10 ( 4 ) units/ml-bacitracin , 500 units/ml ) , gentamicin sulfate ( 0.1 % ) , modified dakins solution ( 25 % ) , and acetic acid ( 0.25 % ) all showed statistically significant ( p less than 0.01 ) decreases in keratinocyte growth rates . | tradename_of | {
"id": "C0809894",
"name": "sulfamylon",
"pos": [
18,
28
]
} | {
"id": "C0024453",
"name": "mafenide acetate",
"pos": [
31,
47
]
} |
the distribution of disulfiram ( antabuse over erythrocyte cell membranes and the inhibitory action of the parent drug and its metabolites on a disulfiram sensitive erythrocyte isozyme of aldehyde dehydrogenase ( aldh ) was investigated in intact and haemolyzed human erythrocytes . | tradename_of | {
"id": "C0591096",
"name": "antabuse",
"pos": [
33,
41
]
} | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
144,
154
]
} |
helixor is an aqueous cold extract from fresh mistletoe , obtained from fir , pine and apple trees . | tradename_of | {
"id": "C0062189",
"name": "helixor",
"pos": [
0,
7
]
} | {
"id": "C1166209",
"name": "extract",
"pos": [
27,
34
]
} |
in its present formulation ( brevital ; eli lilly , indianapolis , ind . ) , the epileptogenic properties of methohexital are limited to patients with psychomotor epilepsy . | tradename_of | {
"id": "C0733444",
"name": "brevital",
"pos": [
29,
37
]
} | {
"id": "C0025668",
"name": "methohexital",
"pos": [
109,
121
]
} |
the media tested were : sodium diatrizoate and megulumine diatrizoate ( e.r . squibb and sons , renogragin-60 and renografin-76 ) , megulumine diatrizoate ( e. r. squibb and sons , renografin-m-60 ) , sodium iothalamate and megulumine iothalamate ( mallinckrodt chemical works , vascoray ) , sodium iothalamate ( mallinckrodt chemical works , conray 400 ) , meglumine iothalamate ( mallinckrodt chemical works , conray 60 ) , and sodium diatrizoate ( winthrop laboratories , hypaque sodium 50 % ) . | tradename_of | {
"id": "C0719484",
"name": "conray",
"pos": [
343,
349
]
} | {
"id": "C0022033",
"name": "meglumine iothalamate",
"pos": [
358,
379
]
} |
until recently two sets of conflicting interpretive criteria existed for use with the standardized 30-mug cefotaxime diffusion disk [ national committee for clinical laboratory standards ( nccls ) m2-a2s , supplement 1 ; product information package insert for claforan ( cefotaxime sodium ) , edition 10/81 . ] | tradename_of | {
"id": "C0701052",
"name": "claforan",
"pos": [
260,
268
]
} | {
"id": "C0700445",
"name": "cefotaxime sodium",
"pos": [
271,
288
]
} |
unfortunately however , the recent revision of the package insert criteria has further confused this issue [ product information package insert for claforan ( cefotaxime sodium ) , edition 2/82 ] . | tradename_of | {
"id": "C0701052",
"name": "claforan",
"pos": [
148,
156
]
} | {
"id": "C0700445",
"name": "cefotaxime sodium",
"pos": [
159,
176
]
} |
the statistical design , randomization , and analysis of the data obtained was performed by one of the authors , a statistician , and the following conclusions were made : dulcolax ( bisacodyl ) plus 2 l tapwater enema is better than all the other protocols in all parts of the colon for both genders and all ages . | tradename_of | {
"id": "C0591416",
"name": "dulcolax",
"pos": [
172,
180
]
} | {
"id": "C0005632",
"name": "bisacodyl",
"pos": [
183,
192
]
} |
peritrate ( pentaerythritol tetranitrate ) , a nitrate coronary vasodilator , was capable of significantly increasing perfusion and function in ischemic heart muscle . | tradename_of | {
"id": "C0878358",
"name": "peritrate",
"pos": [
0,
9
]
} | {
"id": "C0030858",
"name": "pentaerythritol tetranitrate",
"pos": [
12,
40
]
} |
six months after resection of the primary tumor , lymph node metastases were detected and treatment with o , p'-ddd [ 1,1 dichloro-2- ( o-chlorophenyl ) -2- ( p-chlorophenyl ) ethane ] ( lysodren/mitotane ) was started . | tradename_of | {
"id": "C0702007",
"name": "lysodren",
"pos": [
187,
195
]
} | {
"id": "C0026256",
"name": "mitotane",
"pos": [
196,
204
]
} |
in a study of the corneal toxicity of some commonly used presurgical skin antiseptics , we used biomicroscopy , corneal pachymetry , healing studies , and electron microscopy to compare tincture of iodine ( 2 % iodine , 2.35 % sodium iodine , and 46 % ethanol ) , hibiclens ( 4 % chlorhexidine and 4 % isopropyl alcohol with detergent ) , phisohex ( 3 % hexachlorophene and detergent ) , lavacol ( 70 % ethanol ) , 7.5 % povidone iodine scrub ( with a detergent ) , and 10 % povidone iodine solution ( without a detergent ) in rabbits . | tradename_of | {
"id": "C0308205",
"name": "phisohex",
"pos": [
339,
347
]
} | {
"id": "C0019435",
"name": "hexachlorophene",
"pos": [
354,
369
]
} |
the second group ( n-group ) was anaesthetised with nembutal ( sodium pentobarbital ) , the third group with chloralosane ( c-group ) and the fourth group with hypnorm ( h-group ) . | tradename_of | {
"id": "C0702208",
"name": "nembutal",
"pos": [
52,
60
]
} | {
"id": "C0700349",
"name": "sodium pentobarbital",
"pos": [
63,
83
]
} |
relative to the solution , lasix had reduced chloride excretion ( 0.88 ) and frusemide recovery ( 0.80 ) while diurin and frusid had reduced frusemide recoveries ( 0.90 and 0.92 respectively ) there were no other significant differences . | tradename_of | {
"id": "C0699992",
"name": "lasix",
"pos": [
27,
32
]
} | {
"id": "C0016860",
"name": "frusemide",
"pos": [
141,
150
]
} |
we examined in 47 dogs the effects of 5-fluorouracil , adriamycin ( doxorubicin hydrochloride ) , cis-platinum ( cis-diamminedichloroplatinum ) cyclophosphamide , and bleomycin given in association with osmotic blood-brain barrier modification . | tradename_of | {
"id": "C0085752",
"name": "adriamycin",
"pos": [
55,
65
]
} | {
"id": "C0546861",
"name": "doxorubicin",
"pos": [
68,
79
]
} |
the minimal inhibitory concentration of azlocillin for pseudomonas aeruginosa is appreciably reduced when combined with the mucolytic agent mesna ( mistabron ) because of an independent bacteriostatic effect of mesna . | tradename_of | {
"id": "C0733874",
"name": "mistabron",
"pos": [
148,
157
]
} | {
"id": "C0000294",
"name": "mesna",
"pos": [
211,
216
]
} |
twenty-six patients were anaesthetized with isoflurane ( forane ) in oxygen using a completely closed-circuit breathing system to which liquid isoflurane was injected . | tradename_of | {
"id": "C0306242",
"name": "forane",
"pos": [
57,
63
]
} | {
"id": "C0022180",
"name": "isoflurane",
"pos": [
143,
153
]
} |
after pre-treatment with leukeran ( chlorambucil ) , methotrexate , fluorouracil and prednisone ( lmfp ) , they were treated with adm , either alone or in combination with other drugs . | tradename_of | {
"id": "C0699996",
"name": "leukeran",
"pos": [
25,
33
]
} | {
"id": "C0008163",
"name": "chlorambucil",
"pos": [
36,
48
]
} |
postoperative management of pain by the use of ponstel ( mefenamic acid ) , a nonsteroidal anti-inflammatory agent . | tradename_of | {
"id": "C0699209",
"name": "ponstel",
"pos": [
47,
54
]
} | {
"id": "C0025152",
"name": "mefenamic acid",
"pos": [
57,
71
]
} |
for this reason , and to minimize the use of addictive narcotics , the author has used a non-narcotic , anti-inflammatory agent called ponstel ( mefenamic acid ) as the mainstay in postoperative management of pain . | tradename_of | {
"id": "C0699209",
"name": "ponstel",
"pos": [
135,
142
]
} | {
"id": "C0025152",
"name": "mefenamic acid",
"pos": [
145,
159
]
} |
also , subjects in whom valium was injected demonstrated significantly more venous sequelae than those in whom 5 % dextrose in water was injected , confirming previous reports that diazepam is irritating to the endothelial lining and thus is thrombogenic . | tradename_of | {
"id": "C0699187",
"name": "valium",
"pos": [
24,
30
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
181,
189
]
} |
a trial of drug regimens for treating plasmodium falciparum malaria was conducted in a refugee camp in eastern thailand where extensive 'fansidar ' ( pyrimethamine-sulfadoxine ) resistance had been demonstrated . | tradename_of | {
"id": "C0060061",
"name": "fansidar",
"pos": [
137,
145
]
} | {
"id": "C0700599",
"name": "pyrimethamine-sulfadoxine",
"pos": [
150,
175
]
} |
lastly , a surviving renal transplant patient continues to have persistent strongyloidiasis despite repeated mintezol ( thiabendazole ) therapy . | tradename_of | {
"id": "C0700007",
"name": "mintezol",
"pos": [
109,
117
]
} | {
"id": "C0039832",
"name": "thiabendazole",
"pos": [
120,
133
]
} |
in two studies including 73 patients the stress reducing effects of the tranquilizer cloxazolam ( olcadil ) and the beta-receptor-blocking drug pindolol ( visken ) were investigated after the application of a single oral dose ( 3 mg cloxazolam , 5 mg pindolol ) . | tradename_of | {
"id": "C0699962",
"name": "visken",
"pos": [
155,
161
]
} | {
"id": "C0031937",
"name": "pindolol",
"pos": [
251,
259
]
} |
we determined by trichometry the rate of hair growth in ten hirsute patients receiving a combination of cyproterone acetate ( ca ) 50 mg/daily and 'diane ' ( ca 2 mg + ethinyl oestradiol 0.05 mg ) . | tradename_of | {
"id": "C0057721",
"name": "diane",
"pos": [
148,
153
]
} | {
"id": "C0056855",
"name": "ca",
"pos": [
158,
160
]
} |
the sulfonated siderophore desferal ( deferrioxamine beta-mesylate ) effectively prevented any uptake of fe from the citrate complex and was unable to remove that fe already bound by either poisoned or active cells . | tradename_of | {
"id": "C0591350",
"name": "desferal",
"pos": [
27,
35
]
} | {
"id": "C0011148",
"name": "deferrioxamine",
"pos": [
38,
52
]
} |
studies on the interaction of trasylol ( aprotinin ) with trypsin-pancreatic secretory trypsin inhibitor ( psti ) complexes and with alpha 2-macroglobulin-trypsin-psti-complexes . | tradename_of | {
"id": "C0592198",
"name": "trasylol",
"pos": [
30,
38
]
} | {
"id": "C0003641",
"name": "aprotinin",
"pos": [
41,
50
]
} |
an analysis of data from a prospective study which compared the effect of conjugated equine oestrogens ( premarin ) with that of piperazine oestrone sulphate ( ogen ) demonstrated that postmenopausal women who received conjugated equine oestrogens had a higher rate of a rise in blood pressure and development of hypertension than women who received piperazine oestrone sulphate . | tradename_of | {
"id": "C0699710",
"name": "premarin",
"pos": [
105,
113
]
} | {
"id": "C0014938",
"name": "conjugated",
"pos": [
219,
229
]
} |
infusion solutions consisting of diazepam injection ( valium ) in glucose 5.5 % , or diazepam emulsion in a lipid emulsion ( intralipid 10 % ) were infused through two different infusion sets ( transcodan l-74 and cutter il ) . | tradename_of | {
"id": "C0699187",
"name": "valium",
"pos": [
54,
60
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
85,
93
]
} |
identification of crystals of the rimino-phenazine compound b663 ( lamprene : clofazimine ) in mouse spleen macrophages by thin layer chromatography and mass spectrum analysis . | tradename_of | {
"id": "C0700047",
"name": "lamprene",
"pos": [
67,
75
]
} | {
"id": "C0008996",
"name": "clofazimine",
"pos": [
78,
89
]
} |
significant changes in the pharmacokinetic interaction of the antibiotics with different diuretics , i.e . mannitol , lasix and furosemide were demonstrated . | tradename_of | {
"id": "C0699992",
"name": "lasix",
"pos": [
118,
123
]
} | {
"id": "C0016860",
"name": "furosemide",
"pos": [
128,
138
]
} |
[ the antihypertensive action of the beta adrenergic blocking agent visken ( pindolol , lb 46 ) in mild and moderate hypertension ] . | tradename_of | {
"id": "C0699962",
"name": "visken",
"pos": [
68,
74
]
} | {
"id": "C0031937",
"name": "pindolol",
"pos": [
77,
85
]
} |
imferon ( lakeside labs. , inc. ) , an iron dextran complex , is widely used for parenteral therapy with iron . | tradename_of | {
"id": "C0701986",
"name": "imferon",
"pos": [
0,
7
]
} | {
"id": "C0022092",
"name": "iron dextran complex",
"pos": [
39,
59
]
} |
in addition to ablation with alcohol , two of the four patients underwent subselective embolization with gelfoam ( absorbable gelatin sponge ) under epinephrine pharmacoangiography , which resulted in the disappearance of the remaining malformations . | tradename_of | {
"id": "C0918040",
"name": "gelfoam",
"pos": [
105,
112
]
} | {
"id": "C0017238",
"name": "absorbable gelatin sponge",
"pos": [
115,
140
]
} |
omnipaque-300 ( iohexol ) , isovue-300 ( iopamidol ) , and hexabrix ( ioxaglate ) were sequentially injected into both common carotid arteries of each patient . | tradename_of | {
"id": "C0729203",
"name": "omnipaque",
"pos": [
0,
9
]
} | {
"id": "C0022005",
"name": "iohexol",
"pos": [
16,
23
]
} |
omnipaque-300 ( iohexol ) , isovue-300 ( iopamidol ) , and hexabrix ( ioxaglate ) were sequentially injected into both common carotid arteries of each patient . | tradename_of | {
"id": "C0729210",
"name": "isovue",
"pos": [
28,
34
]
} | {
"id": "C0022026",
"name": "iopamidol",
"pos": [
41,
50
]
} |
sotradecol -- sodium tetradecyl sulfate -- is a sclerosing agent which has been used for years in the treatment of varicose veins , haemorrhoids and haemangiomata . | tradename_of | {
"id": "C0087006",
"name": "sotradecol",
"pos": [
0,
10
]
} | {
"id": "C0037556",
"name": "sodium tetradecyl sulfate",
"pos": [
14,
39
]
} |
the sinoatrial ( sa ) node was suppressed by injection of nembutal ( pentobarbital sodium ) through the sa nodal artery , and the hearts were paced at 500- to 700-ms intervals . | tradename_of | {
"id": "C0702208",
"name": "nembutal",
"pos": [
58,
66
]
} | {
"id": "C0700349",
"name": "pentobarbital",
"pos": [
69,
82
]
} |
the pharmacokinetics of the cyclosporine a ( csa , sandimmune ) analogue nva2-cyclosporine , or cyclosporine g ( csg ) was investigated in 6 patients with terminal renal failure after a 4-hr intravenous infusion ( 3.5 mg/kg ) and after oral administration ( 600 mg ) of the drug . | tradename_of | {
"id": "C0699604",
"name": "sandimmune",
"pos": [
51,
61
]
} | {
"id": "C0010592",
"name": "cyclosporine",
"pos": [
96,
108
]
} |
only one brand of piroxicam ( feldene ) is currently marketed in the u.s. , and the united states pharmacopeial convention established an official dissolution requirement for piroxicam in 1985 . | tradename_of | {
"id": "C0687717",
"name": "feldene",
"pos": [
30,
37
]
} | {
"id": "C0031990",
"name": "piroxicam",
"pos": [
175,
184
]
} |
[ observations on the 1st autochthonous cases of schistosomiasis of belem , treated with etrenol ( hycanthone metasulphonate ) ] . | tradename_of | {
"id": "C1328672",
"name": "etrenol",
"pos": [
89,
96
]
} | {
"id": "C0020207",
"name": "hycanthone",
"pos": [
99,
109
]
} |
[ orthoclone okt3 ( muromonab cd3 ) -- the indications for and manner of its use . side effects and their prevention ] . | tradename_of | {
"id": "C0733466",
"name": "orthoclone okt3",
"pos": [
2,
17
]
} | {
"id": "C0085379",
"name": "muromonab cd3",
"pos": [
20,
33
]
} |
in controlled release preparations ( asacol , pentasa , salofalk ) , 5-asa is coated with compounds resistant to low ph , but which deliver 5-asa to the intestines at various rates at higher ph values . | tradename_of | {
"id": "C0678172",
"name": "asacol",
"pos": [
37,
43
]
} | {
"id": "C0127615",
"name": "intestines",
"pos": [
153,
163
]
} |
in controlled release preparations ( asacol , pentasa , salofalk ) , 5-asa is coated with compounds resistant to low ph , but which deliver 5-asa to the intestines at various rates at higher ph values . | tradename_of | {
"id": "C0678171",
"name": "pentasa",
"pos": [
46,
53
]
} | {
"id": "C0127615",
"name": "intestines",
"pos": [
153,
163
]
} |
the alkylating agent ifosfamide synthesized according to own method at the institute of pharmaceutical industry , warsaw , was compared in biological evaluations with holoxan ( asta-werke 's ifosfamide ) . | tradename_of | {
"id": "C0733930",
"name": "holoxan",
"pos": [
167,
174
]
} | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
191,
201
]
} |