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In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We used exon - specific PCR / single - strand conformation polymorphism analysis as a screening step for mutations .
### Output Text: | We used exon - specific PCR / single - strand conformation polymorphism analysis as a screening step for mutations . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Subsequent direct sequencing of the target exons identified homozygous mutations in exon 16 of case 1 and in exon 15 of case 2 .
### Output Text: | Subsequent direct sequencing of the target exons identified homozygous mutations in exon 16 of case 1 and in exon 15 of case 2 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The mutation of case 1 was a homozygous T to A transversion at nucleotide 2250 , the third nucleotide of the codon TGT for Cys728 , leading to a stop codon TGA ( C728X ) .
### Output Text: | The mutation of case 1 was a homozygous T to A transversion at nucleotide 2250 , the third nucleotide of the codon TGT for Cys728 , leading to a stop codon TGA ( C728X ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In case 2 , a homozygous 2 - bp deletion ( 2137delTG / 2138delGT / 2139delTG ) caused a frameshift , generating a premature termination codon 4 to 6 nucleotides downstream .
### Output Text: | In case 2 , a homozygous 2 - bp deletion ( 2137delTG / 2138delGT / 2139delTG ) caused a frameshift , generating a premature termination codon 4 to 6 nucleotides downstream . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Family study in case 1 confirmed the genetic nature of the defect .
### Output Text: | Family study in case 1 confirmed the genetic nature of the defect . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Moreover , we detected a novel polymorphism in intron 11 that presumably is linked to the mutation responsible for C7D in case 1 .
### Output Text: | Moreover , we detected a novel polymorphism in intron 11 that presumably is linked to the mutation responsible for <span class="disease">C7D</span> in case 1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Our results indicate that the pathogenesis of C7D is heterogeneous like most of the other deficiencies of complement components . .
### Output Text: | Our results indicate that the pathogenesis of <span class="disease">C7D</span> is heterogeneous like most of the other <span class="disease">deficiencies of complement components</span> . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: HPRT - APRT - deficient mice are not a model for lesch - nyhan syndrome .
### Output Text: | <span class="disease">HPRT - APRT - deficient</span> mice are not a model for <span class="disease">lesch - nyhan syndrome</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Complete hypoxanthine - guanine phosphoribosyl - transferase ( HPRT ) deficiency in humans results in the Lesch - Nyhan syndrome which is characterized , among other features , by compulsive self - injurious behavior .
### Output Text: | <span class="disease">Complete hypoxanthine - guanine phosphoribosyl - transferase ( HPRT ) deficiency</span> in humans results in the <span class="disease">Lesch - Nyhan syndrome</span> which is characterized , among other features , by compulsive self - injurious behavior . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: HPRT - deficient mice generated using mouse embryonic stem cells exhibit none of the behavioral symptoms associated with the Lesch - Nyhan syndrome .
### Output Text: | <span class="disease">HPRT - deficient</span> mice generated using mouse embryonic stem cells exhibit none of the behavioral symptoms associated with the <span class="disease">Lesch - Nyhan syndrome</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Administration of drugs that inhibit adenine phosphoribosyltransferase ( APRT ) in HPRT - deficient mice has produced the suggestion that deficiency of APRT in combination with HPRT - deficiency in mice may lead to self - mutilation behavior [ C . L . Wu and D . W . Melton ( 1993 ) Nature Genet . 3 , 235 - 240 ] .
### Output Text: | Administration of drugs that inhibit adenine phosphoribosyltransferase ( APRT ) in <span class="disease">HPRT - deficient</span> mice has produced the suggestion that <span class="disease">deficiency of APRT</span> in combination with <span class="disease">HPRT - deficiency</span> in mice may lead to self - mutilation behavior [ C . L . Wu and D . W . Melton ( 1993 ) Nature Genet . 3 , 235 - 240 ] . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: To test this proposition , we bred HPRT - APRT - deficient mice .
### Output Text: | To test this proposition , we bred <span class="disease">HPRT - APRT - deficient</span> mice . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Although the doubly - deficient mice excrete adenine and its highly insoluble derivative , 2 , 8 - dihydroxyadenine , which are also associated with human APRT deficiency , additional abnormalities or any self - injurious behavior were not detected .
### Output Text: | Although the doubly - deficient mice excrete adenine and its highly insoluble derivative , 2 , 8 - dihydroxyadenine , which are also associated with human <span class="disease">APRT deficiency</span> , additional abnormalities or any self - injurious behavior were not detected . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Thus , APRT - HPRT - deficient mice , which are devoid of any purine salvage pathways , show no novel phenotype and are not a model for the behavioral abnormalities associated with the Lesch - Nyhan syndrome as previously suggested
### Output Text: | Thus , <span class="disease">APRT - HPRT - deficient</span> mice , which are devoid of any purine salvage pathways , show no novel phenotype and are not a model for the <span class="disease">behavioral abnormalities</span> associated with the <span class="disease">Lesch - Nyhan syndrome</span> as previously suggested |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Somatic alterations of the DPC4 gene in human colorectal cancers in vivo .
### Output Text: | Somatic alterations of the DPC4 gene in human <span class="disease">colorectal cancers</span> in vivo . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: BACKGROUND & AIMS The chromosome region 18q21 has been shown to be frequently deleted in colorectal cancers , and such frequent allelic loss is a hallmark of the presence of a tumor - suppressor gene .
### Output Text: | BACKGROUND & AIMS The chromosome region 18q21 has been shown to be frequently deleted in <span class="disease">colorectal cancers</span> , and such frequent allelic loss is a hallmark of the presence of a tumor - suppressor gene . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The DPC4 gene , which is located at 18q21 , has been identified as a tumor - suppressor gene from examination of pancreatic cancers .
### Output Text: | The DPC4 gene , which is located at 18q21 , has been identified as a tumor - suppressor gene from examination of <span class="disease">pancreatic cancers</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The aim of the present study was to determine if it might also be altered in colorectal cancers .
### Output Text: | The aim of the present study was to determine if it might also be altered in <span class="disease">colorectal cancers</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: METHODS Mutation analyses of the DPC4 gene were performed on complementary DNA samples from 31 primary colorectal cancer specimens using a combination of polymerase chain reaction , single - strand conformation polymorphism , and DNA sequencing .
### Output Text: | METHODS Mutation analyses of the DPC4 gene were performed on complementary DNA samples from 31 primary <span class="disease">colorectal cancer</span> specimens using a combination of polymerase chain reaction , single - strand conformation polymorphism , and DNA sequencing . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: RESULTS Four missense mutations producing amino acid substitutions and a somatic 12 - base pair deletion in the coding region of the DPC4 gene were detected in the 31 cancers ( 16 % ; 5 of 31 ) .
### Output Text: | RESULTS Four missense mutations producing amino acid substitutions and a somatic 12 - base pair deletion in the coding region of the DPC4 gene were detected in the 31 <span class="disease">cancers</span> ( 16 % ; 5 of 31 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: CONCLUSIONS The DPC4 gene may play a role as a tumor - suppressor gene in a fraction of colorectal cancers ; however , while allelic loss at 18q21 is very often seen in colorectal cancers , only a minority show DPC4 mutations , suggesting that there might be another tumor - suppressor gene in this chromosome region . .
### Output Text: | CONCLUSIONS The DPC4 gene may play a role as a tumor - suppressor gene in a fraction of <span class="disease">colorectal cancers</span> ; however , while allelic loss at 18q21 is very often seen in <span class="disease">colorectal cancers</span> , only a minority show DPC4 mutations , suggesting that there might be another tumor - suppressor gene in this chromosome region . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Pleiotropic defects in ataxia - telangiectasia protein - deficient mice .
### Output Text: | Pleiotropic defects in <span class="disease">ataxia - telangiectasia</span> protein - deficient mice . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: We have generated a mouse model for ataxia - telangiectasia by using gene targeting to generate mice that do not express the Atm protein .
### Output Text: | We have generated a mouse model for <span class="disease">ataxia - telangiectasia</span> by using gene targeting to generate mice that do not express the Atm protein . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Atm - deficient mice are retarded in growth , do not produce mature sperm , and exhibit severe defects in T cell maturation while going on to develop thymomas .
### Output Text: | Atm - deficient mice are retarded in growth , do not produce mature sperm , and exhibit severe defects in T cell maturation while going on to develop <span class="disease">thymomas</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Atm - deficient fibroblasts grow poorly in culture and display a high level of double - stranded chromosome breaks .
### Output Text: | Atm - deficient fibroblasts grow poorly in culture and display a high level of double - stranded chromosome breaks . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Atm - deficient thymocytes undergo spontaneous apoptosis in vitro significantly more than controls .
### Output Text: | Atm - deficient thymocytes undergo spontaneous apoptosis in vitro significantly more than controls . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Atm - deficient mice then exhibit many of the same symptoms found in ataxia - telangiectasia patients and in cells derived from them .
### Output Text: | Atm - deficient mice then exhibit many of the same symptoms found in <span class="disease">ataxia - telangiectasia</span> patients and in cells derived from them . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Furthermore , we demonstrate that the Atm protein exists as two discrete molecular species , and that loss of one or of both of these can lead to the development of the disease . .
### Output Text: | Furthermore , we demonstrate that the Atm protein exists as two discrete molecular species , and that loss of one or of both of these can lead to the development of the disease . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The DCC protein and prognosis in colorectal cancer .
### Output Text: | The DCC protein and prognosis in <span class="disease">colorectal cancer</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: BACKGROUND Allelic loss of chromosome 18q predicts a poor outcome in patients with stage II colorectal cancer .
### Output Text: | BACKGROUND Allelic loss of chromosome 18q predicts a poor outcome in patients with <span class="disease">stage II colorectal cancer</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Although the specific gene inactivated by this allelic loss has not been elucidated , the DCC ( deleted in colorectal cancer ) gene is a candidate .
### Output Text: | Although the specific gene inactivated by this allelic loss has not been elucidated , the DCC ( deleted in <span class="disease">colorectal cancer</span> ) gene is a candidate . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: We investigated whether the expression of the DCC protein in tumor cells is a prognostic marker in colorectal carcinoma .
### Output Text: | We investigated whether the expression of the DCC protein in <span class="disease">tumor</span> cells is a prognostic marker in <span class="disease">colorectal carcinoma</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: METHODS The expression of DCC was evaluated immunohistochemically in 132 paraffin - embedded samples from patients with curatively resected stage II and III colorectal carcinomas .
### Output Text: | METHODS The expression of DCC was evaluated immunohistochemically in 132 paraffin - embedded samples from patients with curatively resected <span class="disease">stage II and III colorectal carcinomas</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: The Cox proportional - hazards model was used to adjust for covariates including age , sex , tumor site , degree of tumor differentiation , and use of adjuvant therapy .
### Output Text: | The Cox proportional - hazards model was used to adjust for covariates including age , sex , <span class="disease">tumor</span> site , degree of <span class="disease">tumor</span> differentiation , and use of adjuvant therapy . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: RESULTS The expression of DCC was a strong positive predictive factor for survival in both stage II and stage III colorectal carcinomas .
### Output Text: | RESULTS The expression of DCC was a strong positive predictive factor for survival in both <span class="disease">stage II and stage III colorectal carcinomas</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: In patients with stage II disease whose tumors expressed DCC , the five - year survival rate was 94 .
### Output Text: | In patients with stage II disease whose <span class="disease">tumors</span> expressed DCC , the five - year survival rate was 94 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: 3 percent , whereas in patients with DCC - negative tumors , the survival rate was 61 .
### Output Text: | 3 percent , whereas in patients with <span class="disease">DCC - negative tumors</span> , the survival rate was 61 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: 6 percent ( P < 0 . 001 ) .
### Output Text: | 6 percent ( P < 0 . 001 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: In patients with stage III disease , the respective survival rates were 59 .
### Output Text: | In patients with <span class="disease">stage III disease</span> , the respective survival rates were 59 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: 3 percent and 33 .
### Output Text: | 3 percent and 33 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 2 percent ( P = 0 . 03 ) .
### Output Text: | 2 percent ( P = 0 . 03 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: CONCLUSIONS DCC is a prognostic marker in patients with stage II or stage III colorectal cancer .
### Output Text: | CONCLUSIONS DCC is a prognostic marker in patients with <span class="disease">stage II or stage III colorectal cancer</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In stage II colorectal carcinomas , the absence of DCC identifies a subgroup of patients with lesions that behave like stage III cancers .
### Output Text: | In <span class="disease">stage II colorectal carcinomas</span> , the absence of DCC identifies a subgroup of patients with lesions that behave like <span class="disease">stage III cancers</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: These findings may thus have therapeutic implications in this group of patients
### Output Text: | These findings may thus have therapeutic implications in this group of patients |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Association of anxiety - related traits with a polymorphism in the serotonin transporter gene regulatory region .
### Output Text: | Association of <span class="disease">anxiety - related traits</span> with a polymorphism in the serotonin transporter gene regulatory region . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Transporter - facilitated uptake of serotonin ( 5 - hydroxytryptamine or 5 - HT ) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake - inhibiting antidepressant and antianxiety drugs .
### Output Text: | Transporter - facilitated uptake of serotonin ( 5 - hydroxytryptamine or 5 - HT ) has been implicated in <span class="disease">anxiety</span> in humans and animal models and is the site of action of widely used uptake - inhibiting antidepressant and antianxiety drugs . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Human 5 - HT transporter ( 5 - HTT ) gene transcription is modulated by a common polymorphism in its upstream regulatory region .
### Output Text: | Human 5 - HT transporter ( 5 - HTT ) gene transcription is modulated by a common polymorphism in its upstream regulatory region . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The short variant of the polymorphism reduces the transcriptional efficiency of the 5 - HTT gene promoter , resulting in decreased 5 - HTT expression and 5 - HT uptake in lymphoblasts .
### Output Text: | The short variant of the polymorphism reduces the transcriptional efficiency of the 5 - HTT gene promoter , resulting in decreased 5 - HTT expression and 5 - HT uptake in lymphoblasts . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Association studies in two independent samples totaling 505 individuals revealed that the 5 - HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in anxiety - related personality traits in individuals as well as sibships . .
### Output Text: | Association studies in two independent samples totaling 505 individuals revealed that the 5 - HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in <span class="disease">anxiety - related personality traits</span> in individuals as well as sibships . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Phenotypic and genotypic overlap between atelosteogenesis type 2 and diastrophic dysplasia .
### Output Text: | Phenotypic and genotypic overlap between <span class="disease">atelosteogenesis type 2</span> and <span class="disease">diastrophic dysplasia</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mutations in the diastrophic dysplasia sulfate transporter gene DTDST have been associated with a family of chondrodysplasias that comprises , in order of increasing severity , diastrophic dysplasia ( DTD ) , atelosteogenesis type 2 ( AO2 ) , and achondrogenesis type 1B ( ACG1B ) .
### Output Text: | Mutations in the <span class="disease">diastrophic dysplasia</span> sulfate transporter gene DTDST have been associated with a family of <span class="disease">chondrodysplasias</span> that comprises , in order of increasing severity , <span class="disease">diastrophic dysplasia</span> ( <span class="disease">DTD</span> ) , <span class="disease">atelosteogenesis type 2</span> ( <span class="disease">AO2</span> ) , and <span class="disease">achondrogenesis type 1B</span> ( <span class="disease">ACG1B</span> ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: To learn more about the molecular basis of DTDST chondrodysplasias and about genotype - phenotype correlations , we studied fibroblast cultures of three new patients one with AO - 2 , one with DTD , and one with an intermediate phenotype ( AO2 / DTD ) .
### Output Text: | To learn more about the molecular basis of <span class="disease">DTDST chondrodysplasias</span> and about genotype - phenotype correlations , we studied fibroblast cultures of three new patients one with <span class="disease">AO - 2</span> , one with <span class="disease">DTD</span> , and one with an intermediate phenotype ( <span class="disease">AO2</span> / <span class="disease">DTD</span> ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Reduced incorporation of inorganic sulfate into macromolecules was found in all three .
### Output Text: | Reduced incorporation of inorganic sulfate into macromolecules was found in all three . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Each of the three patients was found to be heterozygous for a c862t transition predicting a R279W substitution in the third extracellular loop of DTDST .
### Output Text: | Each of the three patients was found to be heterozygous for a c862t transition predicting a R279W substitution in the third extracellular loop of DTDST . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In two patients ( DTD and AO2 / DTD ) , no other structural mutation was found , but polymerase chain reaction amplification and single - strand conformation polymorphism analysis of fibroblast cDNA showed reduced mRNA levels of the wild - type DTDST allele these two patients may be compound heterozygotes for the " Finnish " mutation ( as yet uncharacterized at the DNA level ) , which causes reduced expression of DTDST .
### Output Text: | In two patients ( <span class="disease">DTD</span> and <span class="disease">AO2</span> / <span class="disease">DTD</span> ) , no other structural mutation was found , but polymerase chain reaction amplification and single - strand conformation polymorphism analysis of fibroblast cDNA showed reduced mRNA levels of the wild - type DTDST allele these two patients may be compound heterozygotes for the " Finnish " mutation ( as yet uncharacterized at the DNA level ) , which causes reduced expression of DTDST . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
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### Input Text: The third patient ( with AO2 ) had the R279W mutation compounded with a novel mutation , the deletion of cytosine 418 ( delta c418 ) , predicting a frameshift with premature termination .
### Output Text: | The third patient ( with <span class="disease">AO2</span> ) had the R279W mutation compounded with a novel mutation , the deletion of cytosine 418 ( delta c418 ) , predicting a frameshift with premature termination . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Also the delta c418 allele was underrepresented in the cDNA , in accordance with previous observations that premature stop codons reduce mRNA levels .
### Output Text: | Also the delta c418 allele was underrepresented in the cDNA , in accordance with previous observations that premature stop codons reduce mRNA levels . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The presence of the DTDST R279W mutation in a total of 11 patients with AO2 or DTD emphasizes the overlap between these conditions .
### Output Text: | The presence of the DTDST R279W mutation in a total of 11 patients with <span class="disease">AO2</span> or <span class="disease">DTD</span> emphasizes the overlap between these conditions . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: This mutation has not been found so far in 8 analyzed ACG1B patients , suggesting that it allows some residual activity of the sulfate transporter . .
### Output Text: | This mutation has not been found so far in 8 analyzed <span class="disease">ACG1B</span> patients , suggesting that it allows some residual activity of the sulfate transporter . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Identification of WASP mutations , mutation hotspots and genotype - phenotype disparities in 24 patients with the Wiskott - Aldrich syndrome .
### Output Text: | Identification of WASP mutations , mutation hotspots and genotype - phenotype disparities in 24 patients with the <span class="disease">Wiskott - Aldrich syndrome</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The Wiskott - Aldrich syndrome ( WAS ) , an X - linked immunodeficiency disease caused by mutation in the recently isolated gene encoding WAS protein ( WASP ) , is known to be associated with extensive clinical heterogeneity .
### Output Text: | The <span class="disease">Wiskott - Aldrich syndrome</span> ( <span class="disease">WAS</span> ) , an <span class="disease">X - linked immunodeficiency disease</span> caused by mutation in the recently isolated gene encoding <span class="disease">WAS</span> protein ( WASP ) , is known to be associated with extensive clinical heterogeneity . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Cumulative mutation data have revealed that WASP genotypes are also highly variable among WAS patients , but the relationship of phenotype with genotype in this disease remains unclear .
### Output Text: | Cumulative mutation data have revealed that WASP genotypes are also highly variable among <span class="disease">WAS</span> patients , but the relationship of phenotype with genotype in this disease remains unclear . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: To address this issue we characterized WASP mutations in 24 unrelated WAS patients , including 18 boys with severe classical WAS and 6 boys expressing mild forms of the disease , and then examined the degree of correlation of these as well as all previously published WASP mutations with disease severity .
### Output Text: | To address this issue we characterized WASP mutations in 24 unrelated <span class="disease">WAS</span> patients , including 18 boys with severe classical <span class="disease">WAS</span> and 6 boys expressing mild forms of the disease , and then examined the degree of correlation of these as well as all previously published WASP mutations with disease severity . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: By analysis of these compiled mutation data , we demonstrated clustering of WASP mutations within the four most N - terminal exons of the gene and also identified several sites within this region as hotspots for WASP mutation .
### Output Text: | By analysis of these compiled mutation data , we demonstrated clustering of WASP mutations within the four most N - terminal exons of the gene and also identified several sites within this region as hotspots for WASP mutation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These characteristics were observed , however , in both severe and mild cases of the disease .
### Output Text: | These characteristics were observed , however , in both severe and mild cases of the disease . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Similarly , while the cumulative data revealed a predominance of missense mutations among the WASP gene lesions observed in boys with isolated thrombocytopenia , missense mutations were not exclusively associated with milder WAS phenotypes , but also comprised a substantial portion ( 38 % ) of the WASP gene defects found in patients with severe disease .
### Output Text: | Similarly , while the cumulative data revealed a predominance of missense mutations among the WASP gene lesions observed in boys with <span class="disease">isolated thrombocytopenia</span> , missense mutations were not exclusively associated with milder <span class="disease">WAS</span> phenotypes , but also comprised a substantial portion ( 38 % ) of the WASP gene defects found in patients with severe disease . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These findings , as well as the detection of identical WASP mutations in patients with disparate phenotypes , reveal a lack of phenotype concordance with genotype in WAS and thus imply that phenotypic outcome in this disease cannot be reliably predicted solely on the basis of WASP genotypes . .
### Output Text: | These findings , as well as the detection of identical WASP mutations in patients with disparate phenotypes , reveal a lack of phenotype concordance with genotype in <span class="disease">WAS</span> and thus imply that phenotypic outcome in this disease cannot be reliably predicted solely on the basis of WASP genotypes . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Germline mutations in the 3 ' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli .
### Output Text: | Germline mutations in the 3 ' part of <span class="disease">APC</span> exon 15 do not result in truncated proteins and are associated with attenuated <span class="disease">adenomatous polyposis coli</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Familial adenomatous polyposis ( FAP ) is an inherited predisposition to colorectal cancer characterized by the development of numerous adenomatous polyps predominantly in the colorectal region .
### Output Text: | <span class="disease">Familial adenomatous polyposis</span> ( <span class="disease">FAP</span> ) is an inherited predisposition to <span class="disease">colorectal cancer</span> characterized by the development of numerous <span class="disease">adenomatous polyps</span> predominantly in the colorectal region . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Germline mutations in the adenomatous polyposis coli ( APC ) gene are responsible for most cases of FAP .
### Output Text: | Germline mutations in the <span class="disease">adenomatous polyposis coli</span> ( <span class="disease">APC</span> ) gene are responsible for most cases of <span class="disease">FAP</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mutations at the 5 end of APC are known to be associated with a relatively mild form of the disease , called attenuated adenomatous polyposis coli ( AAPC ) .
### Output Text: | Mutations at the 5 end of <span class="disease">APC</span> are known to be associated with a relatively mild form of the disease , called <span class="disease">attenuated adenomatous polyposis coli</span> ( <span class="disease">AAPC</span> ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: We identified a frameshift mutation in the 3 part of exon 15 , resulting in a stop codon at 1862 , in a large Dutch kindred with AAPC .
### Output Text: | We identified a frameshift mutation in the 3 part of exon 15 , resulting in a stop codon at 1862 , in a large Dutch kindred with <span class="disease">AAPC</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Western blot analysis of lymphoblastoid cell lines derived from affected family members from this kindred , as well as from a previously reported Swiss family carrying a frameshift mutation at codon 1987 and displaying a similar attenuated phenotype , showed only the wild - type APC protein .
### Output Text: | Western blot analysis of lymphoblastoid cell lines derived from affected family members from this kindred , as well as from a previously reported Swiss family carrying a frameshift mutation at codon 1987 and displaying a similar attenuated phenotype , showed only the wild - type <span class="disease">APC</span> protein . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Our study indicates that chain - terminating mutations located in the 3 part of APC do not result in detectable truncated polypeptides and we hypothesize that this is likely to be the basis for the observed AAPC phenotype . .
### Output Text: | Our study indicates that chain - terminating mutations located in the 3 part of <span class="disease">APC</span> do not result in detectable truncated polypeptides and we hypothesize that this is likely to be the basis for the observed <span class="disease">AAPC</span> phenotype . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1 .
### Output Text: | Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Over 100 distinct disease - associated mutations have been identified in the breast - ovarian cancer susceptibility gene BRCA1 .
### Output Text: | Over 100 distinct disease - associated mutations have been identified in the <span class="disease">breast - ovarian cancer</span> susceptibility gene BRCA1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Loss of the wild - type allele in > 90 % of tumors from patients with inherited BRCA1 mutations indicates tumor suppressive function .
### Output Text: | Loss of the wild - type allele in > 90 % of <span class="disease">tumors</span> from patients with inherited BRCA1 mutations indicates <span class="disease">tumor</span> suppressive function . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The low incidence of somatic mutations suggests that BRCA1 inactivation in sporadic tumors occurs by alternative mechanisms , such as interstitial chromosomal deletion or reduced transcription .
### Output Text: | The low incidence of somatic mutations suggests that BRCA1 inactivation in sporadic <span class="disease">tumors</span> occurs by alternative mechanisms , such as interstitial chromosomal deletion or reduced transcription . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: To identify possible features of the BRCA1 genomic region that may contribute to chromosomal instability as well as potential transcriptional regulatory elements , a 117 , 143 - bp DNA sequence encompassing BRCA1 was obtained by random sequencing of four cosmids identified from a human chromosome 17 specific library .
### Output Text: | To identify possible features of the BRCA1 genomic region that may contribute to chromosomal instability as well as potential transcriptional regulatory elements , a 117 , 143 - bp DNA sequence encompassing BRCA1 was obtained by random sequencing of four cosmids identified from a human chromosome 17 specific library . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The 24 exons of BRCA1 span an 81 - kb region that has an unusually high density of Alu repetitive DNA ( 41 . 5 % ) , but relatively low density ( 4 . 8 % ) of other repetitive sequences .
### Output Text: | The 24 exons of BRCA1 span an 81 - kb region that has an unusually high density of Alu repetitive DNA ( 41 . 5 % ) , but relatively low density ( 4 . 8 % ) of other repetitive sequences . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: BRCA1 intron lengths range in size from 403 bp to 9 .
### Output Text: | BRCA1 intron lengths range in size from 403 bp to 9 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: 2 kb and contain the intragenic microsatellite markers D17S1323 , D17S1322 , and D17S855 , which localize to introns 12 , 19 , and 20 , respectively .
### Output Text: | 2 kb and contain the intragenic microsatellite markers D17S1323 , D17S1322 , and D17S855 , which localize to introns 12 , 19 , and 20 , respectively . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In addition to BRCA1 , the contig contains two complete genes Rho7 , a member of the rho family of GTP binding proteins , and VAT1 , an abundant membrane protein of cholinergic synaptic vesicles .
### Output Text: | In addition to BRCA1 , the contig contains two complete genes Rho7 , a member of the rho family of GTP binding proteins , and VAT1 , an abundant membrane protein of cholinergic synaptic vesicles . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Partial sequences of the 1A1 - 3B B - box protein pseudogene and IFP 35 , an interferon induced leucine zipper protein , reside within the contig .
### Output Text: | Partial sequences of the 1A1 - 3B B - box protein pseudogene and IFP 35 , an interferon induced leucine zipper protein , reside within the contig . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: An L21 ribosomal protein pseudogene is embedded in BRCA1 intron 13 .
### Output Text: | An L21 ribosomal protein pseudogene is embedded in BRCA1 intron 13 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The order of genes on the chromosome is centromere - 1FP 35 - VAT1 - Rho7 - BRCA1 - 1A1 - 3B - telomere
### Output Text: | The order of genes on the chromosome is centromere - 1FP 35 - VAT1 - Rho7 - BRCA1 - 1A1 - 3B - telomere |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Identification of a RING protein that can interact in vivo with the BRCA1 gene product .
### Output Text: | Identification of a RING protein that can interact in vivo with the BRCA1 gene product . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The hereditary breast and ovarian cancer gene , BRCA1 , encodes a large polypeptide that contains the cysteine - rich RING motif , a zinc - binding domain found in a variety of regulatory proteins .
### Output Text: | The <span class="disease">hereditary breast and ovarian cancer</span> gene , BRCA1 , encodes a large polypeptide that contains the cysteine - rich RING motif , a zinc - binding domain found in a variety of regulatory proteins . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Here we describe a novel protein that interacts in vivo with the N - terminal region of BRCA1 .
### Output Text: | Here we describe a novel protein that interacts in vivo with the N - terminal region of BRCA1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: This BRCA1 - associated RING domain ( BARD1 ) protein contains an N - terminal RING motif , three tandem ankyrin repeats , and a C - terminal sequence with significant homology to the phylogenetically conserved BRCT domains that lie near the C terminus of BRCA1 .
### Output Text: | This BRCA1 - associated RING domain ( BARD1 ) protein contains an N - terminal RING motif , three tandem ankyrin repeats , and a C - terminal sequence with significant homology to the phylogenetically conserved BRCT domains that lie near the C terminus of BRCA1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The BARD1 / BRCA1 interaction is disrupted by BRCA1 missense mutations that segregate with breast cancer susceptibility , indicating that BARD1 may be involved in mediating tumour suppression by BRCA1 . .
### Output Text: | The BARD1 / BRCA1 interaction is disrupted by BRCA1 missense mutations that segregate with <span class="disease">breast cancer</span> susceptibility , indicating that BARD1 may be involved in mediating <span class="disease">tumour</span> suppression by BRCA1 . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two - colour fluorescence analysis .
### Output Text: | Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two - colour fluorescence analysis . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The ability to scan a large gene rapidly and accurately for all possible heterozygous mutations in large numbers of patient samples will be critical for the future of medicine .
### Output Text: | The ability to scan a large gene rapidly and accurately for all possible heterozygous mutations in large numbers of patient samples will be critical for the future of medicine . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: We have designed high - density arrays consisting of over 96 , 600 oligonucleotides 20 - nucleotides ( nt ) in length to screen for a wide range of heterozygous mutations in the 3 .
### Output Text: | We have designed high - density arrays consisting of over 96 , 600 oligonucleotides 20 - nucleotides ( nt ) in length to screen for a wide range of heterozygous mutations in the 3 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: 45 - kilobases ( kb ) exon 11 of the hereditary breast and ovarian cancer gene BRCA1 .
### Output Text: | 45 - kilobases ( kb ) exon 11 of the <span class="disease">hereditary breast and ovarian cancer</span> gene BRCA1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Reference and test samples were co - hybridized to these arrays and differences in hybridization patterns quantitated by two - colour analysis .
### Output Text: | Reference and test samples were co - hybridized to these arrays and differences in hybridization patterns quantitated by two - colour analysis . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Fourteen of fifteen patient samples with known mutations were accurately diagnosed , and no false positive mutations were identified in 20 control samples .
### Output Text: | Fourteen of fifteen patient samples with known mutations were accurately diagnosed , and no false positive mutations were identified in 20 control samples . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Eight single nucleotide polymorphisms were also readily detected .
### Output Text: | Eight single nucleotide polymorphisms were also readily detected . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: DNA chip - based assays may provide a valuable new technology for high - throughput cost - efficient detection of genetic alterations .
### Output Text: | DNA chip - based assays may provide a valuable new technology for high - throughput cost - efficient detection of genetic alterations . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Autosomal dominant primary hyperparathyroidism and jaw tumor syndrome associated with renal hamartomas and cystic kidney disease : linkage to 1q21 - q32 and loss of the wild type allele in renal hamartomas .
### Output Text: | Autosomal dominant primary <span class="disease">hyperparathyroidism and jaw tumor syndrome</span> associated with <span class="disease">renal hamartomas</span> and <span class="disease">cystic kidney disease</span> : linkage to 1q21 - q32 and loss of the wild type allele in <span class="disease">renal hamartomas</span> . |