PatentNumber
stringlengths 10
12
| Year
int64 1.98k
2.02k
| reactions
stringlengths 20
1.76k
| canonical_reactions
stringlengths 20
1.76k
|
|---|---|---|---|
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1.[Na+].[OH-]>C(O)C>Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1 | CC(=O)Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1.[Na+].[OH-]>C(O)C>Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1.O=S(=O)(Cl)C1CC1>>O=S(=O)(Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1)C1CC1 | CC(=O)Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1.O=S(=O)(Cl)C1CC1>>O=S(=O)(Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(CCN5CCOCC5)c4)ccc32)c1)C1CC1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC1(C)OB(c2cc3ccccc3o2)OC1(C)C.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2cc3ccccc3o2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC1(C)OB(c2cc3ccccc3o2)OC1(C)C.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2cc3ccccc3o2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.N#N.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2ccccc2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.N#N.O=C([O-])[O-].OB(O)c1ccccc1.[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2ccccc2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccccc2)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>C1COCC1.O.[Zn]>CC(=O)Nc1cc(N)cc(-c2ccccc2)c1 | CC(=O)Nc1cc(-c2ccccc2)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>C1COCC1.O.[Zn]>CC(=O)Nc1cc(N)cc(-c2ccccc2)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(N)cc(-c2ccccc2)c1.O=[N+]([O-])c1cc(Br)ccc1F.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-c2ccccc2)c1 | CC(=O)Nc1cc(N)cc(-c2ccccc2)c1.O=[N+]([O-])c1cc(Br)ccc1F.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-c2ccccc2)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.COc1ccc(B(O)O)cc1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>COc1ccc(-c2cc(NC(C)=O)cc([N+](=O)[O-])c2)cc1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.COc1ccc(B(O)O)cc1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>COc1ccc(-c2cc(NC(C)=O)cc([N+](=O)[O-])c2)cc1 |
US09447091B2 | 2,016 | COc1ccc(-c2cc(NC(C)=O)cc([N+](=O)[O-])c2)cc1.[Ca+2].[Cl-].[Cl-]>C(O)C.[Fe]>COc1ccc(-c2cc(N)cc(NC(C)=O)c2)cc1 | COc1ccc(-c2cc(NC(C)=O)cc([N+](=O)[O-])c2)cc1.[Ca+2].[Cl-].[Cl-]>C(O)C.[Fe]>COc1ccc(-c2cc(N)cc(NC(C)=O)c2)cc1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.N#N.O=C([O-])[O-].OB(O)c1ccc(F)c(F)c1.[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2ccc(F)c(F)c2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.N#N.O=C([O-])[O-].OB(O)c1ccc(F)c(F)c1.[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2ccc(F)c(F)c2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.N#N.O=C([O-])[O-].OB(O)c1c(F)cccc1F.[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2c(F)cccc2F)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.N#N.O=C([O-])[O-].OB(O)c1c(F)cccc1F.[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2c(F)cccc2F)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2cnn(C)c2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2cnn(C)c2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.O=C([O-])[O-].Oc1ccccn1.[K+].[K+]>C1(C)C=CC=CC=1.[Cu]I>CC(=O)Nc1cc(-n2ccccc2=O)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.O=C([O-])[O-].Oc1ccccn1.[K+].[K+]>C1(C)C=CC=CC=1.[Cu]I>CC(=O)Nc1cc(-n2ccccc2=O)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.O=C([O-])[O-].[Cs+].[Cs+].c1nc[nH]n1>CN(C=O)C.[Cu-]=O>CC(=O)Nc1cc(-n2cncn2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.O=C([O-])[O-].[Cs+].[Cs+].c1nc[nH]n1>CN(C=O)C.[Cu-]=O>CC(=O)Nc1cc(-n2cncn2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-n2cncn2)c1.[Ca+2].[Cl-].[Cl-]>C(O)C.[Fe]>CC(=O)Nc1cc(Nc2ccc(Br)cc2N)cc(-n2cncn2)c1 | CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-n2cncn2)c1.[Ca+2].[Cl-].[Cl-]>C(O)C.[Fe]>CC(=O)Nc1cc(Nc2ccc(Br)cc2N)cc(-n2cncn2)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.N#N.[K+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.N#N.[K+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC1(C)OB(c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)OC1(C)C.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC1(C)OB(c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)OC1(C)C.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2cn(S(=O)(=O)c3ccccc3)c3ccccc23)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.COc1ccc(B(O)O)cn1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>COc1ccc(-c2cc(NC(C)=O)cc([N+](=O)[O-])c2)cn1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.COc1ccc(B(O)O)cn1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>COc1ccc(-c2cc(NC(C)=O)cc([N+](=O)[O-])c2)cn1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCN(C)CC5)nn4)ccc32)c1>Cl>CN1CCC(n2cc(-c3ccc4c(c3)ncn4-c3cc(N)cc(-c4ccc(F)cc4F)c3)nn2)CC1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCN(C)CC5)nn4)ccc32)c1>Cl>CN1CCC(n2cc(-c3ccc4c(c3)ncn4-c3cc(N)cc(-c4ccc(F)cc4F)c3)nn2)CC1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCN(C)CC5)nn4)ccc32)c1.O=S(=O)(Cl)C1CC1>>CN1CCC(n2cc(-c3ccc4c(c3)ncn4-c3cc(NS(=O)(=O)C4CC4)cc(-c4ccc(F)cc4F)c3)nn2)CC1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCN(C)CC5)nn4)ccc32)c1.O=S(=O)(Cl)C1CC1>>CN1CCC(n2cc(-c3ccc4c(c3)ncn4-c3cc(NS(=O)(=O)C4CC4)cc(-c4ccc(F)cc4F)c3)nn2)CC1 |
US09447091B2 | 2,016 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(NC(C)=O)cc(-n3cccc3)c2)cn1.[Na+].[OH-]>C(O)C.C(OCC)(=O)C>CCn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-n3cccc3)c2)cn1 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(NC(C)=O)cc(-n3cccc3)c2)cn1.[Na+].[OH-]>C(O)C.C(OCC)(=O)C>CCn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-n3cccc3)c2)cn1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCN(C)CC5)nn4)cnc32)c1>Cl>CN1CCC(n2cc(-c3cnc4c(c3)ncn4-c3cc(N)cc(-c4ccc(F)cc4F)c3)nn2)CC1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCN(C)CC5)nn4)cnc32)c1>Cl>CN1CCC(n2cc(-c3cnc4c(c3)ncn4-c3cc(N)cc(-c4ccc(F)cc4F)c3)nn2)CC1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2c(F)cccc2F)cc(-n2cnc3cc(-n4cccn4)ccc32)c1.[Na+].[OH-]>C(O)C>Nc1cc(-c2c(F)cccc2F)cc(-n2cnc3cc(-n4cccn4)ccc32)c1 | CC(=O)Nc1cc(-c2c(F)cccc2F)cc(-n2cnc3cc(-n4cccn4)ccc32)c1.[Na+].[OH-]>C(O)C>Nc1cc(-c2c(F)cccc2F)cc(-n2cnc3cc(-n4cccn4)ccc32)c1 |
US09447091B2 | 2,016 | CC(=O)Cl.O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1)C1CC1>C(Cl)Cl>CC(=O)n1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1 | CC(=O)Cl.O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1)C1CC1>C(Cl)Cl>CC(=O)n1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1 |
US09447091B2 | 2,016 | CS(=O)(=O)Cl.O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1)C1CC1.c1ccncc1>C(Cl)Cl>CS(=O)(=O)n1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1 | CS(=O)(=O)Cl.O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1)C1CC1.c1ccncc1>C(Cl)Cl>CS(=O)(=O)n1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(N)cc(-c2c(F)cccc2F)c1.O=[N+]([O-])c1cc(Br)cnc1Cl.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Nc2ncc(Br)cc2[N+](=O)[O-])cc(-c2c(F)cccc2F)c1 | CC(=O)Nc1cc(N)cc(-c2c(F)cccc2F)c1.O=[N+]([O-])c1cc(Br)cnc1Cl.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Nc2ncc(Br)cc2[N+](=O)[O-])cc(-c2c(F)cccc2F)c1 |
US09447091B2 | 2,016 | CN(C)S(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.c1ccncc1>C(Cl)Cl>CNS(=O)(=O)N(C)c1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1 | CN(C)S(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.c1ccncc1>C(Cl)Cl>CNS(=O)(=O)N(C)c1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(Br)ccc32)c1.CC(C)(O)CCn1ccc(B2OC(C)(C)C(C)(C)O2)n1>>CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(-c4cnn(CCC(C)(C)O)c4)ccc32)c1 | CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(Br)ccc32)c1.CC(C)(O)CCn1ccc(B2OC(C)(C)C(C)(C)O2)n1>>CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(-c4cnn(CCC(C)(C)O)c4)ccc32)c1 |
US09447091B2 | 2,016 | CCOC(=O)CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1.[Li+].[OH-]>C1COCC1>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NC(=O)CC(=O)O)cc(-c3ccc(F)cc3F)c2)cn1 | CCOC(=O)CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1.[Li+].[OH-]>C1COCC1>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NC(=O)CC(=O)O)cc(-c3ccc(F)cc3F)c2)cn1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C(=O)CBr)ccc32)c1.NC(N)=S>C(O)C>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnc(N)s4)ccc32)c1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C(=O)CBr)ccc32)c1.NC(N)=S>C(O)C>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnc(N)s4)ccc32)c1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)ccc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)ccc32)c1 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)ccc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)ccc32)c1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)ccc32)c1 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)ccc32)c1 |
US09447091B2 | 2,016 | BrCC1CC1.C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=[N-].[Na+]>CN(C=O)C.[Cu](I)I>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1 | BrCC1CC1.C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=[N-].[Na+]>CN(C=O)C.[Cu](I)I>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1 |
US09447091B2 | 2,016 | C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=NC1CCOCC1>CN(C=O)C.[Cu](I)I>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1 | C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=NC1CCOCC1>CN(C=O)C.[Cu](I)I>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1 |
US09447091B2 | 2,016 | CCOC(=O)Cn1cc(-c2cnc3c(c2)ncn3-c2cc(NC(C)=O)cc(-c3ccc(F)cc3F)c2)nn1.N>CO>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC(N)=O)nn4)cnc32)c1 | CCOC(=O)Cn1cc(-c2cnc3c(c2)ncn3-c2cc(NC(C)=O)cc(-c3ccc(F)cc3F)c2)nn1.N>CO>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC(N)=O)nn4)cnc32)c1 |
US09447091B2 | 2,016 | C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=[N-].[Na+]>CN(C=O)C.[Cu](I)I>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1 | C#Cc1cnc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.[N-]=[N+]=[N-].[Na+]>CN(C=O)C.[Cu](I)I>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4c[nH]nn4)cnc32)c1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(C5CCOCC5)nn4)cnc32)c1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1 |
US09447091B2 | 2,016 | CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1.O=C(O)C1CC1>CN(C=O)C>O=C(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1)C1CC1 | CCN(C(C)C)C(C)C.CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1.O=C(O)C1CC1>CN(C=O)C>O=C(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn(CC5CC5)nn4)cnc32)c1)C1CC1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(N)cc(Br)c1.Cn1cc(-c2ccc(F)c([N+](=O)[O-])c2)cn1.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Br)cc(Nc2ccc(-c3cnn(C)c3)cc2[N+](=O)[O-])c1 | CC(=O)Nc1cc(N)cc(Br)c1.Cn1cc(-c2ccc(F)c([N+](=O)[O-])c2)cn1.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Br)cc(Nc2ccc(-c3cnn(C)c3)cc2[N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccncc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1cc(-c2ccncc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1 | CC(=O)Nc1cc(-c2ccncc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1cc(-c2ccncc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1 |
US09447091B2 | 2,016 | CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Br)cc(-c3ccc(F)cc3F)c2)cn1.N#N.Nc1ncccn1.O=C([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Nc3ncccn3)cc(-c3ccc(F)cc3F)c2)cn1 | CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Br)cc(-c3ccc(F)cc3F)c2)cn1.N#N.Nc1ncccn1.O=C([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Nc3ncccn3)cc(-c3ccc(F)cc3F)c2)cn1 |
US09447091B2 | 2,016 | Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Br)cc(-c3ccc(F)cc3F)c2)cn1.Nc1nccs1>>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Nc3nccs3)cc(-c3ccc(F)cc3F)c2)cn1 | Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Br)cc(-c3ccc(F)cc3F)c2)cn1.Nc1nccs1>>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(Nc3nccs3)cc(-c3ccc(F)cc3F)c2)cn1 |
US09447091B2 | 2,016 | CC(C)(O)CCn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-c3ccc(F)cc3F)c2)cn1.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCC(C)(C)O)c4)ccc32)c1 | CC(C)(O)CCn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-c3ccc(F)cc3F)c2)cn1.CCS(=O)(=O)Cl>>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCC(C)(C)O)c4)ccc32)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)cnc32)c1>C(O)(C(F)(F)F)=O>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(=O)[nH]c4)cnc32)c1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)cnc32)c1>C(O)(C(F)(F)F)=O>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(=O)[nH]c4)cnc32)c1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)cnc32)c1>C(O)(C(F)(F)F)=O>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(=O)[nH]c4)cnc32)c1 | CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)cnc32)c1>C(O)(C(F)(F)F)=O>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(=O)[nH]c4)cnc32)c1 |
US09447091B2 | 2,016 | CC1(C)OB(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)OC1(C)C.Cc1nnc(Br)s1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>Cc1nnc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)s1 | CC1(C)OB(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)OC1(C)C.Cc1nnc(Br)s1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>Cc1nnc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)s1 |
US09447091B2 | 2,016 | CC1(C)OB(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)OC1(C)C.Fc1ccc(Br)nc1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(F)cn4)ccc32)c1)C1CC1 | CC1(C)OB(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)OC1(C)C.Fc1ccc(Br)nc1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(F)cn4)ccc32)c1)C1CC1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.N#N.[K+]>O1CCOCC1.C(OCC)(=O)C.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)cc([N+](=O)[O-])c1 | CC(=O)Nc1cc(Br)cc([N+](=O)[O-])c1.CC(=O)[O-].CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.N#N.[K+]>O1CCOCC1.C(OCC)(=O)C.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC1(C)OB(c2cc(CC(N)=O)cc([N+](=O)[O-])c2)OC1(C)C.COCCOC.Fc1cccnc1Cl.N#N.O=C([O-])[O-].[Na+].[Na+]>C1C=CC(P([C]2[CH][CH][CH][CH]2)C2C=CC=CC=2)=CC=1.C1C=CC(P([C]2[CH][CH][CH][CH]2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl.[Fe]>CC(=O)Nc1cc(-c2ncccc2F)cc([N+](=O)[O-])c1 | CC1(C)OB(c2cc(CC(N)=O)cc([N+](=O)[O-])c2)OC1(C)C.COCCOC.Fc1cccnc1Cl.N#N.O=C([O-])[O-].[Na+].[Na+]>C1C=CC(P([C]2[CH][CH][CH][CH]2)C2C=CC=CC=2)=CC=1.C1C=CC(P([C]2[CH][CH][CH][CH]2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl.[Fe]>CC(=O)Nc1cc(-c2ncccc2F)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ncccc2F)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>C1COCC1.O.[Zn]>CC(=O)Nc1cc(N)cc(-c2ncccc2F)c1 | CC(=O)Nc1cc(-c2ncccc2F)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>C1COCC1.O.[Zn]>CC(=O)Nc1cc(N)cc(-c2ncccc2F)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(N)cc(-c2ncccc2F)c1.O=[N+]([O-])c1cc(Br)ccc1F.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-c2ncccc2F)c1 | CC(=O)Nc1cc(N)cc(-c2ncccc2F)c1.O=[N+]([O-])c1cc(Br)ccc1F.[F-].[K+]>CN(C=O)C>CC(=O)Nc1cc(Nc2ccc(Br)cc2[N+](=O)[O-])cc(-c2ncccc2F)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(Br)cnc32)c1.N#N.[Br-].[Zn+]c1nccs1>C1COCC1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(-c4nccs4)cnc32)c1 | CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(Br)cnc32)c1.N#N.[Br-].[Zn+]c1nccs1>C1COCC1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CC(=O)Nc1cc(-c2ccc(F)cc2)cc(-n2cnc3cc(-c4nccs4)cnc32)c1 |
US09447091B2 | 2,016 | CC(C)n1ccc(B2OC(C)(C)C(C)(C)O2)n1.CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C(C)C)c4)cnc32)c1 | CC(C)n1ccc(B2OC(C)(C)C(C)(C)O2)n1.CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.N#N.O=C([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C(C)C)c4)cnc32)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C#N)ccc32)c1.[K+].[OH-]>C(O)C>NC(=O)c1ccc2c(c1)ncn2-c1cc(N)cc(-c2ccc(F)cc2F)c1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C#N)ccc32)c1.[K+].[OH-]>C(O)C>NC(=O)c1ccc2c(c1)ncn2-c1cc(N)cc(-c2ccc(F)cc2F)c1 |
US09447091B2 | 2,016 | CCN1CCNCC1.O=C(O)[C@@H]1CCCN1.O=C([O-])[O-].O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)ccc32)c1)C1CC1.[K+].[K+]>CS(C)=O.[Cu]I>CCN1CCN(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)CC1 | CCN1CCNCC1.O=C(O)[C@@H]1CCCN1.O=C([O-])[O-].O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)ccc32)c1)C1CC1.[K+].[K+]>CS(C)=O.[Cu]I>CCN1CCN(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)CC1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1 | CCS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.c1ccncc1>C(Cl)Cl>CCS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1 |
US09447091B2 | 2,016 | CC(=O)Cl.CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCOC5CCCCO5)c4)ccc32)c1>CO>Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCO)c4)ccc32)c1 | CC(=O)Cl.CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCOC5CCCCO5)c4)ccc32)c1>CO>Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCO)c4)ccc32)c1 |
US09447091B2 | 2,016 | Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C4=CNC(OCc5ccccc5)C=C4)ccc32)c1.O=C=NCc1ccco1>C(Cl)Cl>O=C(NCc1ccco1)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)ccc32)c1 | Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C4=CNC(OCc5ccccc5)C=C4)ccc32)c1.O=C=NCc1ccco1>C(Cl)Cl>O=C(NCc1ccco1)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)ccc32)c1 |
US09447091B2 | 2,016 | CC(=O)Cl.CS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCOC5CCCCO5)c4)ccc32)c1>CO>CS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCO)c4)ccc32)c1 | CC(=O)Cl.CS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCOC5CCCCO5)c4)ccc32)c1>CO>CS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(CCO)c4)ccc32)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(N)cc(-c2ccc(F)cc2F)c1.COC(=O)c1ccc(F)c([N+](=O)[O-])c1.[F-].[K+]>CN(C=O)C>COC(=O)c1ccc(Nc2cc(NC(C)=O)cc(-c3ccc(F)cc3F)c2)c([N+](=O)[O-])c1 | CC(=O)Nc1cc(N)cc(-c2ccc(F)cc2F)c1.COC(=O)c1ccc(F)c([N+](=O)[O-])c1.[F-].[K+]>CN(C=O)C>COC(=O)c1ccc(Nc2cc(NC(C)=O)cc(-c3ccc(F)cc3F)c2)c([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | CS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.c1ccncc1>C(Cl)Cl>CS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1 | CS(=O)(=O)Cl.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.c1ccncc1>C(Cl)Cl>CS(=O)(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1 |
US09447091B2 | 2,016 | CC1(C)OB(c2cnn(C3CCCC3)c2)OC1(C)C.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.O=S(=O)(Cl)C1CC1>>O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C5CCCC5)c4)cnc32)c1)C1CC1 | CC1(C)OB(c2cnn(C3CCCC3)c2)OC1(C)C.Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)cnc32)c1.O=S(=O)(Cl)C1CC1>>O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(C5CCCC5)c4)cnc32)c1)C1CC1 |
US09447091B2 | 2,016 | CCS(=O)(=O)Cl.Cn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-c3cc(F)ccc3F)c2)cn1>>CCS(=O)(=O)Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1 | CCS(=O)(=O)Cl.Cn1cc(-c2ccc3c(c2)ncn3-c2cc(N)cc(-c3cc(F)ccc3F)c2)cn1>>CCS(=O)(=O)Nc1cc(-c2cc(F)ccc2F)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)c1 |
US09447091B2 | 2,016 | Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C4=CNC(OCc5ccccc5)C=C4)ccc32)c1.O=C1OCCN1S(=O)(=O)NC1CC1>N1C=CC=CC=1>NS(=O)(=O)NC1CC1c1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)ccc32)c1 | Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(C4=CNC(OCc5ccccc5)C=C4)ccc32)c1.O=C1OCCN1S(=O)(=O)NC1CC1>N1C=CC=CC=1>NS(=O)(=O)NC1CC1c1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4ccc(OCc5ccccc5)nc4)ccc32)c1 |
US09447091B2 | 2,016 | CC1(C)OB(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)OC1(C)C.Cn1cc(Br)c(N)n1.N#N.O=C([O-])[O-].[Cs+].[Cs+]>C1COCC1.CCO.O.CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)c(N)n1 | CC1(C)OB(c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)OC1(C)C.Cn1cc(Br)c(N)n1.N#N.O=C([O-])[O-].[Cs+].[Cs+]>C1COCC1.CCO.O.CC(C)([P](C(C)(C)C)([Pd][P](C(C)(C)C)(C(C)(C)C)C(C)(C)C)C(C)(C)C)C>Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)c(N)n1 |
US09447091B2 | 2,016 | CC(=O)c1ccc2c(c1)ncn2-c1cc(NS(=O)(=O)C2CC2)cc(-c2ccc(F)cc2F)c1.Cl.NO>C(O)C>C/C(=N/O)c1ccc2c(c1)ncn2-c1cc(NS(=O)(=O)C2CC2)cc(-c2ccc(F)cc2F)c1 | CC(=O)c1ccc2c(c1)ncn2-c1cc(NS(=O)(=O)C2CC2)cc(-c2ccc(F)cc2F)c1.Cl.NO>C(O)C>C/C(=N/O)c1ccc2c(c1)ncn2-c1cc(NS(=O)(=O)C2CC2)cc(-c2ccc(F)cc2F)c1 |
US09447091B2 | 2,016 | C#Cc1ccc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.CCOC(=O)CN=[N+]=[N-].O=C1O[C@H]([C@@H](O)CO)C([O-])=C1O.[Na+]>C(O)(C)(C)C.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Cu+2]>CCOC(=O)Cn1nncc1-c1ccc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1 | C#Cc1ccc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1.CCOC(=O)CN=[N+]=[N-].O=C1O[C@H]([C@@H](O)CO)C([O-])=C1O.[Na+]>C(O)(C)(C)C.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Cu+2]>CCOC(=O)Cn1nncc1-c1ccc2c(c1)ncn2-c1cc(NC(C)=O)cc(-c2ccc(F)cc2F)c1 |
US09447091B2 | 2,016 | C[O-].O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1.[Na+]>CO>COc1cc(Br)cc([N+](=O)[O-])c1 | C[O-].O=[N+]([O-])c1cc(Br)cc([N+](=O)[O-])c1.[Na+]>CO>COc1cc(Br)cc([N+](=O)[O-])c1 |
US09447091B2 | 2,016 | COc1cc(Br)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>C1COCC1.O.[Zn]>COc1cc(N)cc(Br)c1 | COc1cc(Br)cc([N+](=O)[O-])c1.[Cl-].[NH4+]>C1COCC1.O.[Zn]>COc1cc(N)cc(Br)c1 |
US09447091B2 | 2,016 | CN(C)CC(=O)O.Cl.O=C([O-])[O-].O=C1CCCN1.O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)ccc32)c1)C1CC1.[K+].[K+]>CS(C)=O.[Cu]I>O=C1CCCN1c1ccc2c(c1)ncn2-c1cc(NS(=O)(=O)C2CC2)cc(-c2ccc(F)cc2F)c1 | CN(C)CC(=O)O.Cl.O=C([O-])[O-].O=C1CCCN1.O=S(=O)(Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(Br)ccc32)c1)C1CC1.[K+].[K+]>CS(C)=O.[Cu]I>O=C1CCCN1c1ccc2c(c1)ncn2-c1cc(NS(=O)(=O)C2CC2)cc(-c2ccc(F)cc2F)c1 |
US09447091B2 | 2,016 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1.O=S(=O)(Cl)C1CC1.c1ccncc1>C(Cl)Cl>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(S(=O)(=O)C5CC5)c4)ccc32)c1 | CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cn[nH]c4)ccc32)c1.O=S(=O)(Cl)C1CC1.c1ccncc1>C(Cl)Cl>CC(=O)Nc1cc(-c2ccc(F)cc2F)cc(-n2cnc3cc(-c4cnn(S(=O)(=O)C5CC5)c4)ccc32)c1 |
US09447117B2 | 2,016 | CN(C)C=O.Cc1cnc(C(=O)O)c(Br)c1.O=C([O-])[O-].[K+].[K+].c1cn[nH]n1>>Cc1cnc(C#N)c(-n2ccnn2)c1.Cc1cnc(C#N)c(-n2nccn2)c1 | CN(C)C=O.Cc1cnc(C(=O)O)c(Br)c1.O=C([O-])[O-].[K+].[K+].c1cn[nH]n1>>Cc1cnc(C#N)c(-n2ccnn2)c1.Cc1cnc(C#N)c(-n2nccn2)c1 |
US09447117B2 | 2,016 | Cc1cnc(C(=O)[O-])c(-n2nccn2)c1.[Na+].[Na+].[OH-]>CCO>Cc1cnc(C(=O)O)c(-n2nccn2)c1 | Cc1cnc(C(=O)[O-])c(-n2nccn2)c1.[Na+].[Na+].[OH-]>CCO>Cc1cnc(C(=O)O)c(-n2nccn2)c1 |
US09447117B2 | 2,016 | Cc1cnc(C#N)c(Br)c1.O=C([O-])[O-].[K+].[K+].c1cn[nH]n1>CN(C=O)C>Cc1ccc(-n2nccn2)c(C#N)n1 | Cc1cnc(C#N)c(Br)c1.O=C([O-])[O-].[K+].[K+].c1cn[nH]n1>CN(C=O)C>Cc1ccc(-n2nccn2)c(C#N)n1 |
US09447117B2 | 2,016 | CCO.Cc1ccc(-n2nccn2)c(C#N)n1.[Na+].[OH-]>>Cc1ccc(-n2nccn2)c(C(=O)O)n1 | CCO.Cc1ccc(-n2nccn2)c(C#N)n1.[Na+].[OH-]>>Cc1ccc(-n2nccn2)c(C(=O)O)n1 |
US09447117B2 | 2,016 | CCOC(=O)c1c(N)ncc2ccccc12.O=N[O-].[Na+].[Na+].[OH-]>OS(O)(=O)=O>CCOC(=O)c1c(O)ncc2ccccc12 | CCOC(=O)c1c(N)ncc2ccccc12.O=N[O-].[Na+].[Na+].[OH-]>OS(O)(=O)=O>CCOC(=O)c1c(O)ncc2ccccc12 |
US09447117B2 | 2,016 | CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCO.CCOC(=O)c1c(O)ncc2ccccc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>C1COCC1>CCOC(=O)c1c(OCC)ncc2ccccc12 | CC(C)OC(=O)/N=N/C(=O)OC(C)C.CCO.CCOC(=O)c1c(O)ncc2ccccc12.c1ccc(P(c2ccccc2)c2ccccc2)cc1>C1COCC1>CCOC(=O)c1c(OCC)ncc2ccccc12 |
US09447117B2 | 2,016 | CCOC(=O)c1c(OCC)ncc2ccccc12.[Na+].[OH-]>CO>CCOc1ncc2ccccc2c1C(=O)O | CCOC(=O)c1c(OCC)ncc2ccccc12.[Na+].[OH-]>CO>CCOc1ncc2ccccc2c1C(=O)O |
US09447117B2 | 2,016 | Brc1ncccn1.COC(=O)c1c(OC)cccc1B1OC(C)(C)C(C)(C)O1.O.O=C([O-])[O-].[Na+].[Na+]>C1COCC1.CC(P(C(C)(C)C)[C-]1C=CC=C1)(C)C.CC(P(C(C)(C)C)[C-]1C=CC=C1)(C)C.Cl[Pd]Cl.[Fe+2].CCOC(C)=O>COC(=O)c1c(OC)cccc1-c1ncccn1 | Brc1ncccn1.COC(=O)c1c(OC)cccc1B1OC(C)(C)C(C)(C)O1.O.O=C([O-])[O-].[Na+].[Na+]>C1COCC1.CC(P(C(C)(C)C)[C-]1C=CC=C1)(C)C.CC(P(C(C)(C)C)[C-]1C=CC=C1)(C)C.Cl[Pd]Cl.[Fe+2].CCOC(C)=O>COC(=O)c1c(OC)cccc1-c1ncccn1 |
US09447117B2 | 2,016 | COC(=O)c1c(OC)cccc1-c1ncccn1.[Na+].[OH-]>C1COCC1>COc1cccc(-c2ncccn2)c1C(=O)O | COC(=O)c1c(OC)cccc1-c1ncccn1.[Na+].[OH-]>C1COCC1>COc1cccc(-c2ncccn2)c1C(=O)O |
US09447117B2 | 2,016 | C=CC=O.COc1cccc(N)c1C(=O)O>O1CCOCC1>COc1ccc2cccnc2c1C(=O)O | C=CC=O.COc1cccc(N)c1C(=O)O>O1CCOCC1>COc1ccc2cccnc2c1C(=O)O |
US09447117B2 | 2,016 | COc1ccc2cccnc2c1C(=O)O>Br>O=C(O)c1c(O)ccc2cccnc12 | COc1ccc2cccnc2c1C(=O)O>Br>O=C(O)c1c(O)ccc2cccnc12 |
US09447117B2 | 2,016 | CCOC(=O)c1c(OCC)ccc2cccnc12.CO.Cl.O.[Li]O>C1COCC1.O>CCOc1ccc2cccnc2c1C(=O)O | CCOC(=O)c1c(OCC)ccc2cccnc12.CO.Cl.O.[Li]O>C1COCC1.O>CCOc1ccc2cccnc2c1C(=O)O |
US09447117B2 | 2,016 | CCCC[Sn](CCCC)(CCCC)c1ncco1.CCOC(=O)c1cccc(C)c1I>COCCOC.[Cu]I.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>CCOC(=O)c1cccc(C)c1-c1ncco1 | CCCC[Sn](CCCC)(CCCC)c1ncco1.CCOC(=O)c1cccc(C)c1I>COCCOC.[Cu]I.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>CCOC(=O)c1cccc(C)c1-c1ncco1 |
US09447117B2 | 2,016 | CCOC(=O)c1cccc(C)c1-c1ncco1.[Na+].[OH-]>CO>Cc1cccc(C(=O)O)c1-c1ncco1 | CCOC(=O)c1cccc(C)c1-c1ncco1.[Na+].[OH-]>CO>Cc1cccc(C(=O)O)c1-c1ncco1 |
US09447117B2 | 2,016 | CC1(C)OB(c2ccn[nH]2)OC1(C)C.CCOC(=O)c1c(Br)cccc1OC.O=C([O-])[O-].[Na+].[Na+]>COCCOC.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>CCOC(=O)c1c(OC)cccc1-c1ccn[nH]1 | CC1(C)OB(c2ccn[nH]2)OC1(C)C.CCOC(=O)c1c(Br)cccc1OC.O=C([O-])[O-].[Na+].[Na+]>COCCOC.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>CCOC(=O)c1c(OC)cccc1-c1ccn[nH]1 |
US09447117B2 | 2,016 | COC(=O)c1ccccc1-c1c(C)cnn1C.[Li+].[OH-]>CO>Cc1cnn(C)c1-c1ccccc1C(=O)O | COC(=O)c1ccccc1-c1c(C)cnn1C.[Li+].[OH-]>CO>Cc1cnn(C)c1-c1ccccc1C(=O)O |
US09447117B2 | 2,016 | CN(C)[C@@H]1CCCC[C@H]1N.O=C(O)c1cccc(F)c1I.O=C([O-])[O-].[Cs+].[Cs+].c1cn[nH]n1>O1CCOCC1.O.[Cu]I>O=C(O)c1cccc(F)c1-n1ccnn1 | CN(C)[C@@H]1CCCC[C@H]1N.O=C(O)c1cccc(F)c1I.O=C([O-])[O-].[Cs+].[Cs+].c1cn[nH]n1>O1CCOCC1.O.[Cu]I>O=C(O)c1cccc(F)c1-n1ccnn1 |
US09447117B2 | 2,016 | CC(N)c1ccccc1.O=C(O[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1.O=C(O[C@H](C(=O)O)[C@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1>>C[C@H](c1ccccc1)N1C[C@H]2C=C[C@@H]1C2 | CC(N)c1ccccc1.O=C(O[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1.O=C(O[C@H](C(=O)O)[C@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1>>C[C@H](c1ccccc1)N1C[C@H]2C=C[C@@H]1C2 |
US09447117B2 | 2,016 | BrCc1ccccc1.O=C([O-])[O-].O=C1N[C@@H]2C=C[C@H]1C2.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>C1COCC1>C1=C[C@@H]2C[C@H]1CN2Cc1ccccc1 | BrCc1ccccc1.O=C([O-])[O-].O=C1N[C@@H]2C=C[C@H]1C2.[Al+3].[H-].[H-].[H-].[H-].[Li+].[Na+].[Na+]>C1COCC1>C1=C[C@@H]2C[C@H]1CN2Cc1ccccc1 |
US09447117B2 | 2,016 | CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Oc3ccc(C(F)(F)F)cn3)[C@@H]1C2.Cl>CCOC(C)=O.O1CCOCC1>FC(F)(F)c1ccc(O[C@@H]2C[C@@H]3CN[C@H]2C3)nc1 | CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Oc3ccc(C(F)(F)F)cn3)[C@@H]1C2.Cl>CCOC(C)=O.O1CCOCC1>FC(F)(F)c1ccc(O[C@@H]2C[C@@H]3CN[C@H]2C3)nc1 |
US09447117B2 | 2,016 | CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Oc3ccc(Br)cn3)[C@@H]1C2.Cl>CCOC(C)=O.O1CCOCC1>Brc1ccc(O[C@@H]2C[C@@H]3CN[C@H]2C3)nc1 | CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Oc3ccc(Br)cn3)[C@@H]1C2.Cl>CCOC(C)=O.O1CCOCC1>Brc1ccc(O[C@@H]2C[C@@H]3CN[C@H]2C3)nc1 |
US09447117B2 | 2,016 | CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Nc3ccc(C(F)(F)F)cn3)[C@@H]1C2.Cl>CCOC(C)=O.O1CCOCC1>FC(F)(F)c1ccc(N[C@@H]2C[C@@H]3CN[C@H]2C3)nc1 | CC(C)(C)OC(=O)N1C[C@H]2C[C@@H](Nc3ccc(C(F)(F)F)cn3)[C@@H]1C2.Cl>CCOC(C)=O.O1CCOCC1>FC(F)(F)c1ccc(N[C@@H]2C[C@@H]3CN[C@H]2C3)nc1 |
US09447122B2 | 2,016 | CCC(C)=O.Clc1ccc(N2CCNCC2)cc1Cl.O=C([O-])[O-].[K+].[K+]>>OCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 | CCC(C)=O.Clc1ccc(N2CCNCC2)cc1Cl.O=C([O-])[O-].[K+].[K+]>>OCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 |
US09447122B2 | 2,016 | II.OCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>C(Cl)Cl>Clc1ccc(N2CCN(CCCI)CC2)cc1Cl | II.OCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1.c1c[nH]cn1.c1ccc(P(c2ccccc2)c2ccccc2)cc1>C(Cl)Cl>Clc1ccc(N2CCN(CCCI)CC2)cc1Cl |
US09447113B2 | 2,016 | BrB(Br)Br.COC1(O)C=Cc2sc3sc4ccccc4c3c2C1.ClCCl>C(Cl)Cl>Oc1ccc2sc3sc4ccccc4c3c2c1 | BrB(Br)Br.COC1(O)C=Cc2sc3sc4ccccc4c3c2C1.ClCCl>C(Cl)Cl>Oc1ccc2sc3sc4ccccc4c3c2c1 |
US09447113B2 | 2,016 | CC1(C)OB(c2cccc(-c3cccc(-c4cccc5c4sc4ccccc45)c3)c2)OC1(C)C.Cc1ccccc1.O=P([O-])([O-])[O-].O=S(=O)(Oc1ccc2sc3sc4ccccc4c3c2c1)C(F)(F)F.[K+].[K+].[K+].c1cc(-c2cccc(-c3cccc4c3sc3ccccc34)c2)cc(-c2ccc3sc4sc5ccccc5c4c3c2)c1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1.O>c1cc(-c2ccc3c4ccccc4c4ccccc4c3c2)cc(-c2ccc3sc4sc5ccccc5c4c3c2)c1 | CC1(C)OB(c2cccc(-c3cccc(-c4cccc5c4sc4ccccc45)c3)c2)OC1(C)C.Cc1ccccc1.O=P([O-])([O-])[O-].O=S(=O)(Oc1ccc2sc3sc4ccccc4c3c2c1)C(F)(F)F.[K+].[K+].[K+].c1cc(-c2cccc(-c3cccc4c3sc3ccccc34)c2)cc(-c2ccc3sc4sc5ccccc5c4c3c2)c1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1.O>c1cc(-c2ccc3c4ccccc4c4ccccc4c3c2)cc(-c2ccc3sc4sc5ccccc5c4c3c2)c1 |
US09447134B2 | 2,016 | C=C(C)c1cccc(C(C)(C)N=C=O)c1.Nc1ccc(Cl)cc1>ClCCl>C=C(C)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)cc2)c1 | C=C(C)c1cccc(C(C)(C)N=C=O)c1.Nc1ccc(Cl)cc1>ClCCl>C=C(C)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)cc2)c1 |
US09447134B2 | 2,016 | C/C(=N\O)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1.Cl.NCCCl.[H-].[Na+]>CN(C=O)C>C/C(=N\OCCN)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 | C/C(=N\O)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1.Cl.NCCCl.[H-].[Na+]>CN(C=O)C>C/C(=N\OCCN)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1 |